CN107462628A - A kind of thrombus detection device for elasticity and detection method based on magnetic - Google Patents
A kind of thrombus detection device for elasticity and detection method based on magnetic Download PDFInfo
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- CN107462628A CN107462628A CN201710827299.1A CN201710827299A CN107462628A CN 107462628 A CN107462628 A CN 107462628A CN 201710827299 A CN201710827299 A CN 201710827299A CN 107462628 A CN107462628 A CN 107462628A
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- 238000001514 detection method Methods 0.000 title claims abstract description 58
- 208000007536 Thrombosis Diseases 0.000 title claims abstract description 19
- 239000008280 blood Substances 0.000 claims abstract description 33
- 210000004369 blood Anatomy 0.000 claims abstract description 33
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 6
- 230000005672 electromagnetic field Effects 0.000 claims description 6
- 238000012360 testing method Methods 0.000 claims description 2
- 238000011895 specific detection Methods 0.000 abstract 1
- 238000013461 design Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 230000033764 rhythmic process Effects 0.000 description 3
- 230000002429 anti-coagulating effect Effects 0.000 description 2
- 230000005611 electricity Effects 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 238000000418 atomic force spectrum Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001846 repelling effect Effects 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
- G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a kind of thrombus detection device for elasticity and detection method based on magnetic, the bottom of frame is provided with the first support, motor is provided with first support, and magnetic field is connected with the output end of the motor module occurs, generation module in magnetic field is arranged above detection cup, the detection cup is fixed in frame by the second support, detects the magnetic field sensor that is arranged above of cup, and magnetic field sensor is fixed in frame by the 3rd support.In specific detection, respectively by shifting blood sample to detecting cup, and detection reagent is added；Magnetic is added, forms magnetic film；Start the magnetic field of change；Magnetic field variation signal is obtained, detects and analyzes to obtain four steps of result.The present invention is by detecting situation of change of the changes of magnetic field situation with applying magnetic field in blood sample, it can detect that due to situation of change caused by blood sample, the situation of the thrombus elastic force of detected sample can be extrapolated, so as to realize the detection of thrombus elastic force, is worked well.
Description
Technical field
The present invention relates to a kind of thrombus detection device for elasticity and detection method based on magnetic.
Background technology
Thrombelastogram detection scheme in the market is substantially just only a kind of, using blood cup body rotation shearing side
Formula, rotary torsion is measured, realize the detection of thrombus elastic force, analysis forms thrombelastogram.It is if right using this detection scheme
It is all complex in the design of torsion wire, selection and processing, for example to reach the diameter of torsion wire requirement, and need to ensure its torsion
Force curve, technological requirement is very high, and uniformity is not fine, while sufficiently complex to the detection scheme of torsion, process yet.
The content of the invention
In view of the shortcomings of the prior art, an object of the present invention is to provide a kind of thrombus elastic force detection based on magnetic
Device.
Technical scheme is as follows：A kind of thrombus detection device for elasticity based on magnetic, including frame, the frame
Bottom be provided with the first support, be vertically arranged with motor on first support, the output end of the motor upward, and
Magnetic field is connected with the output end of the motor module occurs, the magnetic field generation module is arranged above detection cup, the inspection
Survey cup to be fixed in the frame by the second support, the detection cup is arranged above magnetic field sensor, the magnetic
Field sensor is fixed in the frame by the 3rd support.
Using above technical scheme, frame is used for playing a part of body supports, and the first support is used for fixed support magnetic
Module and motor occur for field.Motor is used for band moving field and module rotation occurs, and magnetic field occurs module and is used for producing magnetic field, to detection
The blood sample of cup the inside has an impact.Detection cup is detected for filling blood sample to be detected.Second support is used for supporting and consolidating
Regular inspection surveys cup, and detection cup is arranged in frame.Magnetic field sensor is used for receiving the signal of changes of magnetic field, and signal is transmitted
Go out.3rd support is used for that magnetic field sensor is supported and is fixed in frame.
Further, for the ease of controlling the magnetic field of magnetic field generator, module, which occurs, for the magnetic field includes an electromagnetic field hair
Raw device, and the North-South polarity of the electromagnetic field generator is laterally setting.
Further, in order to detect faint changes of magnetic field, the magnetic field sensor is micro- magnetic field sensor.
Further, in order to control the rotation of magnetic field generator to change with certain rhythm and pace of moving things, the motor is stepper motor.
The second object of the present invention is to provide a kind of detection method of the thrombus detection device for elasticity based on magnetic, and it is special
Sign is to comprise the following steps：
Step 1) first takes 0.3ml-0.6ml blood sample into cup, then adds detection reagent into the cup, and by blood
Sample is mixed, and then the blood sample after mixing is transferred in the detection cup with liquid-transfering gun；
Blood sample of the step 2) into the detection cup is homogeneously added into 0.04g-0.07g magnetic, then keeps blood sample to exist
14s-17s is stood in the detection cup；
Step 3) starts the motor by control system, and magnetic field described in the motor driven occurs module and rotated, described
Motor is stepper motor, and the step pitch of the stepper motor is 0.9 °, a diameter of 35mm, and coordinates 64 subdivision drivers, the stepping
Motor uses the angle that 10s rotates 4 ° 45 ' as a cycle, and the controlling curve of the stepper motor is sine wave curve；
Step 4) is tested and analyzed by the signal that the magnetic field sensor obtains in supporting computer system, and is carried out
Display.
The detection reagent added in above step 1 is used for releasing anticoagulant effect, in step 2, is put into by dispersed-powder
It into blood sample, can be influenceed by magnetic field, and changes of magnetic field is transmitted to magnetic field sensor, electricity is show in particular in step 3
The type and facilities of machine, it is the rotation rhythm and pace of moving things in order to control magnetic field that module occurs, and then to influence the changes of magnetic field of magnetic.
The changes of magnetic field received is delivered to supporting computer system and is tested and analyzed and handled by magnetic field sensor, and is shown
Come.
Beneficial effect:Present inventive concept is novel and reasonable in design, by detecting changes of magnetic field situation and application magnetic in blood sample
The situation of change of field, you can detect due to situation of change caused by blood sample, you can extrapolate the blood of detected sample
The situation of bolt elastic force, so as to realize the detection of thrombus elastic force, work well.
Brief description of the drawings
Fig. 1 is the structural representation of the present invention.
Embodiment
The invention will be further described with reference to the accompanying drawings and examples：
A kind of thrombus detection device for elasticity based on magnetic as shown in Figure 1, including frame 1, the bottom of frame 1 are provided with
First support 2, motor 3 is vertically arranged with the first support 2, motor 3 is stepper motor.The output end of motor 3 upward, and
Magnetic field is connected with the output end of the motor 3 module 4 occurs, module 4, which occurs, for magnetic field includes an electromagnetic field generator, and the electricity
The North-South polarity of magnetic field generator is laterally sets, and generation module 4 in magnetic field is arranged above detecting cup 5, and the detection cup 5 is logical
Cross the second support 6 to be fixed in frame 1, detection cup 5 is arranged above magnetic field sensor 7, and magnetic field sensor 7 passes through the
Three supports 8 are fixed in frame 1.Magnetic field sensor 7 is micro- magnetic field sensor.
Principle of device in the present invention is as follows, and frame 1 is used for playing a part of body supports, and the first support 2 is used for solid
Surely support magnetic field that module 4 and motor 3 occurs.Motor 3 is used for band moving field generation module 4 and rotated, and magnetic field occurs module 4 and is used for producing
Magnetisation field, the blood sample of the inside of detection cup 5 is had an impact.Magnetic field occurs module 4 and uses electromagnetic field generator, for the sum of magnetic pole
The setting of magnetic field intensity is more convenient.Motor 3 is for causing module 4 occurs for magnetic field to produce precession, to magnetic using stepper motor
Powder produces the influence of pulsed.Detection cup 5 is detected for filling blood sample to be detected.Second support 6 is used for supporting and consolidating
Regular inspection surveys cup 5, and detection cup 5 is arranged in frame 1.Magnetic field sensor 7 is used for receiving the signal of changes of magnetic field, and by signal
Pass.3rd support 8 is used for that magnetic field sensor 7 is supported and is fixed in frame 1.Magnetic field sensor 7 uses micro- magnetic
Field sensor, magnetic field variation signal faint caused by magnetic can be received.
A kind of detection method of the thrombus detection device for elasticity based on magnetic, has following steps：
Step 1) first takes 0.3ml-0.6ml blood sample into cup, then adds detection reagent into the cup, and by blood
Sample is mixed, and then the blood sample after mixing is transferred in the detection cup 5 with liquid-transfering gun；
Blood sample of the step 2) into the detection cup 5 is homogeneously added into 0.04g-0.07g magnetic, then keeps blood sample to exist
14s-17s is stood in the detection cup 5；
Step 3) starts the motor 3 by control system, and the motor 3 drives the magnetic field that module 4 occurs and rotated, institute
It is stepper motor to state motor 3, and the step pitch of the stepper motor is 0.9 °, a diameter of 35mm, and coordinates 64 subdivision drivers, the step
Stepper motor uses the angle that 10s rotates 4 ° 45 ' as a cycle, and the controlling curve of the stepper motor is sine wave curve；
The signal that step 4) is obtained by the magnetic field sensor 7 tests and analyzes in supporting computer system, goes forward side by side
Row display.
Due to adding anticoagulant in blood sampling, so the detection reagent added in above step 1 is used for releasing
Anticoagulant effect.In step 2, it is put into blood sample, magnetic uniformly scatters in blood sample, and formation carries by dispersed-powder
The magnetic film of polarity, and there is good adhesiveness with blood sample.When the magnetic field generation module 4 by rotation, first magnetic
Magnetic pole due to repelling and phase absorption, produce a fixed magnetic field arrangement.When module 4 occurs for magnetic field with the rotation of motor 3,
The magnetic viscosity certain because blood has, and there is certain hysteresis quality, the change in magnetic field is detected by magnetic field sensor 7,
Situation of change that is i.e. detectable and analyzing blood sample, and then the thrombus elastic force situation of detected sample is extrapolated, so as to realize blood
Bolt elastic force detects.Calculate and analyze data specifically has supporting computer system to complete.Motor 3 is show in particular in step 3
Type and facilities, it is the rotation rhythm and pace of moving things in order to control magnetic field that module 4 occurs, and then to influence the changes of magnetic field of magnetic, makees
For a dependent variable of changes of magnetic field detection.The changes of magnetic field that 7 receive is delivered to supporting department of computer science by magnetic field sensor
System is tested and analyzed and handled, and is shown.
Preferred embodiment of the invention described in detail above.It should be appreciated that one of ordinary skill in the art without
Creative work can is needed to make many modifications and variations according to the design of the present invention.Therefore, all technologies in the art
Personnel are available by logical analysis, reasoning, or a limited experiment on the basis of existing technology under this invention's idea
Technical scheme, all should be in the protection domain being defined in the patent claims.
Claims (5)
- A kind of 1. thrombus detection device for elasticity based on magnetic, it is characterised in that：Including frame (1), the bottom of the frame (1) The first support (2) is provided with, motor (3), the output end of the motor (3) are vertically arranged with first support (2) Upward, and in the output end of the motor (3) it is connected with magnetic field and module (4) occurs, the magnetic field occurs to set directly over module (4) Detection cup (5) is equipped with, the detection cup (5) is fixed in the frame (1) by the second support (6), the detection cup (5) Magnetic field sensor (7) is arranged above, the magnetic field sensor (7) is fixed on the frame (1) by the 3rd support (8) On.
- A kind of 2. thrombus detection device for elasticity based on magnetic as claimed in claim 1, it is characterised in that：The magnetic field occurs Module (4) includes an electromagnetic field generator, and the North-South polarity of the electromagnetic field generator is laterally setting.
- A kind of 3. thrombus detection device for elasticity based on magnetic as claimed in claim 2, it is characterised in that：The magnetic field sensing Device (7) is micro- magnetic field sensor.
- A kind of 4. thrombus detection device for elasticity based on magnetic as claimed in claim 3, it is characterised in that：The motor (3) For stepper motor.
- 5. a kind of detection method using the thrombus detection device for elasticity based on magnetic as claimed in claim 4, its feature exists In comprising the following steps：Step 1) first takes 0.3ml-0.6ml blood sample into cup, detection reagent is then added into the cup, and blood sample is mixed It is even, then the blood sample after mixing is transferred in the detection cup (5) with liquid-transfering gun；Blood sample of the step 2) into the detection cup (5) is homogeneously added into 0.04g-0.07g magnetic, then keeps blood sample in institute State and 14s-17s is stood in detection cup (5)；Step 3) starts the motor (3) by control system, and the motor (3) drives the magnetic field that module (4) occurs and rotated, The motor (3) is stepper motor, and the step pitch of the stepper motor is 0.9 °, a diameter of 35mm, and coordinates 64 subdivision drivers, The stepper motor uses the angle that 10s rotates 4 ° 45 ' as a cycle, and the controlling curve of the stepper motor is sinusoidal curve Line；The signal that step 4) is obtained by the magnetic field sensor (7) tests and analyzes in supporting computer system, and carries out Display.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710827299.1A CN107462628A (en) | 2017-09-14 | 2017-09-14 | A kind of thrombus detection device for elasticity and detection method based on magnetic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710827299.1A CN107462628A (en) | 2017-09-14 | 2017-09-14 | A kind of thrombus detection device for elasticity and detection method based on magnetic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107462628A true CN107462628A (en) | 2017-12-12 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710827299.1A Pending CN107462628A (en) | 2017-09-14 | 2017-09-14 | A kind of thrombus detection device for elasticity and detection method based on magnetic |
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Citations (9)
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|---|---|---|---|---|
| FR2572527A1 (en) * | 1984-10-30 | 1986-05-02 | Bertin & Cie | METHOD AND DEVICE FOR MEASURING RHEOLOGICAL CHARACTERISTICS OF A FLUID, IN PARTICULAR A BIOLOGICAL FLUID SUCH AS BLOOD |
| DE102004009089A1 (en) * | 2003-12-17 | 2005-07-21 | Boehringer Ingelheim Microparts Gmbh | Method and device for determining the viscosity |
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| US20140165710A1 (en) * | 2011-07-27 | 2014-06-19 | Kyoto Electronics Manufacturing Co., Ltd. | Viscosity measuring apparatus |
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| US20140165710A1 (en) * | 2011-07-27 | 2014-06-19 | Kyoto Electronics Manufacturing Co., Ltd. | Viscosity measuring apparatus |
| CN204286987U (en) * | 2014-12-08 | 2015-04-22 | 重庆南方数控设备有限责任公司 | Laser reflecting measurement blood viscosity device |
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| CN207198091U (en) * | 2017-09-14 | 2018-04-06 | 重庆南方数控设备有限责任公司 | A kind of thrombus detection device for elasticity based on magnetic |
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Application publication date: 20171212 |