CN105712932A - 一种含1-甲基-3-芳基-4-氯吡唑结构的吡唑肟醚化合物的制备和应用 - Google Patents
一种含1-甲基-3-芳基-4-氯吡唑结构的吡唑肟醚化合物的制备和应用 Download PDFInfo
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- CN105712932A CN105712932A CN201610131294.0A CN201610131294A CN105712932A CN 105712932 A CN105712932 A CN 105712932A CN 201610131294 A CN201610131294 A CN 201610131294A CN 105712932 A CN105712932 A CN 105712932A
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- China
- Prior art keywords
- methyl
- aryl
- compound
- ether compound
- oxime ether
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- QHGKABGMVFALIB-UILLLHFISA-N CC(/C(/C=N/O)=C(\NC)/Oc(cc1)ccc1Br)=N Chemical compound CC(/C(/C=N/O)=C(\NC)/Oc(cc1)ccc1Br)=N QHGKABGMVFALIB-UILLLHFISA-N 0.000 description 1
- IGWIZVOJHCLVAF-UHFFFAOYSA-O CC(C(C)(F)Cl)ON=CC(C(C)=N)=C([NH2+]C)Oc(cc1)ccc1F Chemical compound CC(C(C)(F)Cl)ON=CC(C(C)=N)=C([NH2+]C)Oc(cc1)ccc1F IGWIZVOJHCLVAF-UHFFFAOYSA-O 0.000 description 1
- JHSZRJWCTSDJOA-UHFFFAOYSA-O CC(C(C=NOCc([n](C)nc1-c(cc2)ccc2Cl)c1Cl)=C([NH2+]C)Oc(cc1)ccc1Br)=N Chemical compound CC(C(C=NOCc([n](C)nc1-c(cc2)ccc2Cl)c1Cl)=C([NH2+]C)Oc(cc1)ccc1Br)=N JHSZRJWCTSDJOA-UHFFFAOYSA-O 0.000 description 1
- 0 CC(C)(C)*C(c1ccc(CON=Cc(c(C)n[n]2C)c2Oc(cc2)ccc2Cl)cc1)=O Chemical compound CC(C)(C)*C(c1ccc(CON=Cc(c(C)n[n]2C)c2Oc(cc2)ccc2Cl)cc1)=O 0.000 description 1
- KSNVWDNUCPCIBX-LPYMAVHISA-N CC(C)OC(c1ccc(CO/N=C/c(c(C)n[n]2C)c2N2CCCC2)cc1)=O Chemical compound CC(C)OC(c1ccc(CO/N=C/c(c(C)n[n]2C)c2N2CCCC2)cc1)=O KSNVWDNUCPCIBX-LPYMAVHISA-N 0.000 description 1
- XMKMTUFHJFCOMW-UHFFFAOYSA-N CNN(C)CC(F)(Cl)Cl Chemical compound CNN(C)CC(F)(Cl)Cl XMKMTUFHJFCOMW-UHFFFAOYSA-N 0.000 description 1
- HSUYGORNPLDGTL-UHFFFAOYSA-N C[n](c(CCl)c1Cl)nc1-c(cc1)ccc1Cl Chemical compound C[n](c(CCl)c1Cl)nc1-c(cc1)ccc1Cl HSUYGORNPLDGTL-UHFFFAOYSA-N 0.000 description 1
- QJQUZNFRSLAUJE-VGOFMYFVSA-N Cc1n[n](C)c(OC2C=CC(F)=CC2)c1/C=N/O Chemical compound Cc1n[n](C)c(OC2C=CC(F)=CC2)c1/C=N/O QJQUZNFRSLAUJE-VGOFMYFVSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
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CN201610131294.0A CN105712932B (zh) | 2016-03-08 | 2016-03-08 | 一种含1-甲基-3-芳基-4-氯吡唑结构的吡唑肟醚化合物的制备和应用 |
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CN201610131294.0A CN105712932B (zh) | 2016-03-08 | 2016-03-08 | 一种含1-甲基-3-芳基-4-氯吡唑结构的吡唑肟醚化合物的制备和应用 |
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CN105712932A true CN105712932A (zh) | 2016-06-29 |
CN105712932B CN105712932B (zh) | 2019-01-22 |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106432081A (zh) * | 2016-07-26 | 2017-02-22 | 南通大学 | 含4‑氯‑3‑乙基‑1‑甲基吡唑结构的吡唑肟醚化合物的制备方法和应用 |
CN109879867A (zh) * | 2019-03-06 | 2019-06-14 | 南通大学 | 一种含5-芳基噁唑结构的吡唑肟醚类化合物的制备和应用 |
CN110357820A (zh) * | 2019-08-14 | 2019-10-22 | 南通大学 | 一种含1-甲基-3-取代苯基吡唑结构的吡唑肟醚化合物及其制备方法和用途 |
CN111393413A (zh) * | 2020-05-12 | 2020-07-10 | 南通大学 | 一种含氯代吡啶联苯基单元的吡唑类化合物及其制备方法和应用 |
CN111393416A (zh) * | 2020-05-05 | 2020-07-10 | 南通大学 | 含1-甲基吡啶-3-(4-氯苯基)吡唑单元的吡唑化合物的制备方法和应用 |
CN111423415A (zh) * | 2020-05-05 | 2020-07-17 | 南通大学 | 一种含氯代吡啶环联吡唑单元的吡唑肟衍生物及其制备方法和用途 |
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WO2007084868A2 (en) * | 2006-01-17 | 2007-07-26 | Kalypsys, Inc. | Treatment of disorders by activation of the unfolded protein response |
CN102675205A (zh) * | 2012-05-25 | 2012-09-19 | 安徽农业大学 | 一种吡唑肟醚类化合物及其制备与在抗癌治疗中的应用 |
CN104725366A (zh) * | 2015-02-28 | 2015-06-24 | 南通大学 | 含5-烷氧基噻二唑结构的三氟甲基吡唑肟类衍生物的制备方法和用途 |
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2016
- 2016-03-08 CN CN201610131294.0A patent/CN105712932B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007084868A2 (en) * | 2006-01-17 | 2007-07-26 | Kalypsys, Inc. | Treatment of disorders by activation of the unfolded protein response |
CN102675205A (zh) * | 2012-05-25 | 2012-09-19 | 安徽农业大学 | 一种吡唑肟醚类化合物及其制备与在抗癌治疗中的应用 |
CN104725366A (zh) * | 2015-02-28 | 2015-06-24 | 南通大学 | 含5-烷氧基噻二唑结构的三氟甲基吡唑肟类衍生物的制备方法和用途 |
Non-Patent Citations (1)
Title |
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HYUN-JA PARK ET AL: "Identification of antitumor activity of pyrazole oxime ethers", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 * |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106432081A (zh) * | 2016-07-26 | 2017-02-22 | 南通大学 | 含4‑氯‑3‑乙基‑1‑甲基吡唑结构的吡唑肟醚化合物的制备方法和应用 |
CN106432081B (zh) * | 2016-07-26 | 2020-03-31 | 南通大学 | 含4-氯-3-乙基-1-甲基吡唑结构的吡唑肟醚化合物的制备方法和应用 |
CN109879867A (zh) * | 2019-03-06 | 2019-06-14 | 南通大学 | 一种含5-芳基噁唑结构的吡唑肟醚类化合物的制备和应用 |
CN109879867B (zh) * | 2019-03-06 | 2022-03-01 | 南通大学 | 一种含5-芳基噁唑结构的吡唑肟醚类化合物的制备和应用 |
CN110357820A (zh) * | 2019-08-14 | 2019-10-22 | 南通大学 | 一种含1-甲基-3-取代苯基吡唑结构的吡唑肟醚化合物及其制备方法和用途 |
CN111393416A (zh) * | 2020-05-05 | 2020-07-10 | 南通大学 | 含1-甲基吡啶-3-(4-氯苯基)吡唑单元的吡唑化合物的制备方法和应用 |
CN111423415A (zh) * | 2020-05-05 | 2020-07-17 | 南通大学 | 一种含氯代吡啶环联吡唑单元的吡唑肟衍生物及其制备方法和用途 |
CN111393416B (zh) * | 2020-05-05 | 2022-08-12 | 南通大学 | 含1-甲基吡啶-3-(4-氯苯基)吡唑单元的吡唑化合物的制备方法和应用 |
CN111393413A (zh) * | 2020-05-12 | 2020-07-10 | 南通大学 | 一种含氯代吡啶联苯基单元的吡唑类化合物及其制备方法和应用 |
CN111393413B (zh) * | 2020-05-12 | 2022-05-27 | 南通大学 | 一种含氯代吡啶联苯基单元的吡唑类化合物及其制备方法和应用 |
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Effective date of registration: 20201125 Address after: 239300 Yang Cun town Industrial Park, Anhui, Chuzhou, Tianchang Patentee after: Anhui xianshengda pesticide Co., Ltd Address before: 226019 No.205, building 6, Nantong University, No.9, Siyuan Road, Nantong City, Jiangsu Province Patentee before: Center for technology transfer, Nantong University |
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