CN105616559A - Composition for treating acute bacillary dysentery - Google Patents

Composition for treating acute bacillary dysentery Download PDF

Info

Publication number
CN105616559A
CN105616559A CN201610095594.8A CN201610095594A CN105616559A CN 105616559 A CN105616559 A CN 105616559A CN 201610095594 A CN201610095594 A CN 201610095594A CN 105616559 A CN105616559 A CN 105616559A
Authority
CN
China
Prior art keywords
herba
parts
bacillary dysentery
graperoot
acute bacillary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201610095594.8A
Other languages
Chinese (zh)
Inventor
不公告发明人
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CN105616559A publication Critical patent/CN105616559A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285—Aucklandia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/40—Cornaceae (Dogwood family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention discloses a composition for treating acute bacillary dysentery.The composition is mainly prepared from, by weight, 18-40 parts of purslane, 6-9 parts of momordica cochinchinensis, 10-20 parts of Chinese pulsatilla roots, 5-15 parts of costustoot, 15-25 parts of capitate knotweed herb, 6-12 parts of Zornia gibbosa Spanog., 3-10 parts of largeleaf dogwood bark, 5-12 parts of graperoot and 15-25 parts of honeysuckle.The traditional Chinese medicine composition is scientific in formula, simple in preparation method and convenient to use, and has the effects of clearing away heat, promoting diuresis, clearing away toxin and cooling the blood on acute bacillary dysentery.

Description

The compositions for the treatment of acute bacillary dysentery
Divisional application, original applying number 2014105827025, applying date 2014.10.28, title acute bacillary dysentery QiReLiShi herbs compositions and preparation method.
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of acute bacillary dysentery QiReLiShi herbs compositions and preparation method.
Background technology
Bacillary dysentery is children's's a kind of infectious intestinal disease more typically, caused by dysentery bacterium. Clinically with heating, stomachache, diarrhoea, tenesmus and arrange the loose stool of mucous, pus and blood for its cardinal symptom. Clinically course of disease person within 2 months is called acute bacillary dysentery, point 3 types, namely plain edition, light-duty and toxic type. Plain edition shows as heating of feeling cold, stomachache, diarrhoea, accompanies tenesmus. Stomachache, based on left lower quadrant, in paroxysmal, alleviates greatly after an action of the bowels. Stool every day tens times to tens times, typical case person is that mucus bloody purulent stool is with tenesmus sense. Toxic type acute bacillary dysentery onset is hurried, and change rapidly, can behave as high heat, headache, vomiting, irritated, drowsiness, even blood pressure drops, consciousness changing. Treatment acute bacillary dysentery is usually by having Western medicine at present, and the antidiarrheal effect of Western medicine is fast but stomach, liver can be caused injury in various degree, and side effect is bigger.
Publication No. CN103417671A(application number 201210175550.8) Chinese patent literature disclose a kind of Chinese medicine treating acute bacillary dysentery, it is made up of the component of following weight portion: Semen Plantaginis 40-50 gram, Radix Sophorae Flavescentis 20-40 gram, Fructus Crataegi (parched to brown) 15-25 gram, grinds to the powder altogether. Publication No. CN102772598A(application number 201210295050.8) Chinese patent literature disclose a kind of Chinese medicine treating bacillary dysentery. The Chinese medicine of this treatment bacillary dysentery is with Rhizoma Acori Graminei, Spica Prunellae, Folium Isatidis, the Radix Aucklandiae, Fructus Crataegi, storage, Flos Narcissi chinensis, Flos Sophorae, Herba Portulacae, Flos Hibisci, Herba Agrimoniae, Cortex Pini Massonianae, Herba Salviae Chinensis, flower of poplar, Radix Sanguisorbae and Flos Musae for raw material, formulated according to certain weight proportion. Publication No. CN103417590A(application number 201210182815.7) Chinese patent literature disclose a kind of Chinese medicine treating chronic bacillary dysentery, it is characterized in that it is made up of the component of following weight portion: Pericarpium Granati 50 grams, Radix Angelicae Sinensis 15 grams uses clear water decoction, and once clothes go down.
Now for the treatment of dysentery mainly based on doctor trained in Western medicine, quickly but side effect is very big for therapeutic effect, and liver is easily generated injury, and Chinese traditional treatment of comparing is more suitable for, but because traditional Chinese medical science theory is different, effect difference is relatively big, so also needing to further research.
Summary of the invention
For problem of the prior art, it is an object of the invention to provide the Chinese medicine composition of the treatment acute bacillary dysentery that a kind of effect is notable, take safety has no side effect.
The technical scheme is that
Acute bacillary dysentery QiReLiShi herbs compositions, is mainly prepared from by following bulk drugs, is weight portion: Herba Portulacae 18-40; Semen Momordicae 6-9; Radix Pulsatillae 10-20; Radix Aucklandiae 5-15; Herba Polygoni Capitati 15-25; Herba Zornia Diphyllae 6-12; Cortex Corni macrophyllae 3-10; Graperoot 5-12; Flos Lonicerae 15-25.
Preferred scheme is: Herba Portulacae 20-38; Semen Momordicae 7-8; Radix Pulsatillae 12-18; Radix Aucklandiae 8-12; Herba Polygoni Capitati 18-22; Herba Zornia Diphyllae 8-10; Cortex Corni macrophyllae 5-8; Graperoot 7-10; Flos Lonicerae 18-22.
More preferably: Herba Portulacae 29, Semen Momordicae 7.5, the Radix Pulsatillae 15, the Radix Aucklandiae 10, Herba Polygoni Capitati 20, Herba Zornia Diphyllae 9, Cortex Corni macrophyllae 6.5, graperoot 8.5, Flos Lonicerae 20.
Present invention also offers and this Chinese medicine composition is made pharmaceutically acceptable decoction, thick paste agent, pill and granule.
The preparation method of described decoction is:
(1) Semen Momordicae being removed impurity, be ground into powder, cross 40-60 mesh sieve (preferably 50 order), be then placed in pot, the dry stir-fry of little fire, to there being fragrance to blow out, is taken out standby;
(2) taking Cortex Corni macrophyllae addition rice vinegar to mix thoroughly, vexed moisture-inhibiting is moistened, and the time is 15-20 minute (being preferably 18 minutes), after vinegar is sucked, puts into container, slow fire heating fried dry, and taking-up is dried in the air cool standby;
(3) Herba Portulacae, the Radix Pulsatillae, the Radix Aucklandiae, graperoot rinse shave are placed in marmite, and add water retting 1-3 hour (preferably 2 hours), after intense fire is boiled, add step (1) (2) gains and the Herba Polygoni Capitati cleaned, Herba Zornia Diphyllae, Flos Lonicerae, turn little fire and decoct 40-60 minute (preferably 50 minutes), filter;
(4) recrement boiling again, filters, merges with step (3) gained filtrate and be concentrated into 1/2nd of original volume, and sterilizing encapsulation obtains Chinese medicine composition decoction.
The preparation method of described decoction, 6-8 times (preferably 7 times) that amount is medical material weight that step (3) adds water.
The preparation method of described thick paste is:
(1) Semen Momordicae being removed impurity, be ground into powder, cross 40-60 mesh sieve (preferably 50 order), be then placed in pot, the dry stir-fry of little fire, to there being fragrance to blow out, is taken out standby;
(2) taking Cortex Corni macrophyllae addition rice vinegar to mix thoroughly, vexed moistening, the time is 15-20 minute (preferably 18 minutes), after vinegar is sucked, puts into container, slow fire heating fried dry, and taking-up is dried in the air cool standby;
(3) Herba Portulacae, the Radix Pulsatillae, the Radix Aucklandiae, graperoot rinse shave are placed in marmite, and add water retting 1-3 hour (preferably 2 hours), after intense fire is boiled, add step (1) (2) gains and the Herba Polygoni Capitati cleaned, Herba Zornia Diphyllae, Flos Lonicerae, turn little fire to decoct 50 minutes, filter;
(4) recrement boiling again, the persistent period is 30 minutes, filters and merges with step (3) gained filtrate, is concentrated into relative density 1.20-1.30(60 DEG C) thick paste of (preferably 1.25), sterilizing, obtain thick paste agent.
The preparation method of described pill is:
(1) Semen Momordicae being removed impurity, be ground into powder, cross 70-90 mesh sieve (preferably 80 order), be then placed in pot, the dry stir-fry of little fire, to there being fragrance to blow out, is taken out standby;
(2) take Cortex Corni macrophyllae add rice vinegar mix thoroughly, vexed moistening, the time is 15-20 minute (preferably 18 minutes), after vinegar is sucked, puts into container, slow fire heating fried dry, take out dry in the air cool grind to form end standby;
(3) Herba Portulacae, the Radix Pulsatillae, the Radix Aucklandiae, graperoot rinse shave are placed in marmite, and add water retting 1-3 hour (preferably 2 hours), after intense fire is boiled, add clean Herba Polygoni Capitati, Herba Zornia Diphyllae, Flos Lonicerae, turn little fire decoct 50 minutes, filter;
(4) by step (1), (2), (3) gained medicated powder and filtrate mix homogeneously, adding refined honey according to the ratio of 4:1, make and have plastic ball bar, sterilizing segmentation is packaged to be the pill of 0.5g/.
The preparation method of described granule is:
(1) Semen Momordicae being removed impurity, be ground into powder, cross 70-90 mesh sieve (preferably 80 order), be then placed in pot, the dry stir-fry of little fire, to there being fragrance to blow out, is taken out standby;
(2) take Cortex Corni macrophyllae add rice vinegar mix thoroughly, vexed moistening, the time is 15-20 minute (preferably 18 minutes), after vinegar is sucked, puts into container, slow fire heating fried dry, take out dry in the air cool grind to form end standby;
(3) Herba Portulacae, the Radix Pulsatillae, the Radix Aucklandiae, graperoot rinse shave are placed in marmite, and add water retting 1-3 hour (preferably 2 hours), after intense fire is boiled, add clean Herba Polygoni Capitati, Herba Zornia Diphyllae, Flos Lonicerae, turn little fire decoct 50 minutes, filter;
(4) recrement boiling again, filter, it is combined and concentrated to relative density 1.18-1.21(60 DEG C with step (3) gained filtrate) thick paste of (preferably Ei 1.20), add step (1) (2) gained medicated powder, mix homogeneously, make the soft material that light pressure then dissipates, be pressed through 14-18 mesh sieve, dry at 70 DEG C and obtain Chinese medicine granules.
Present invention also offers the application when the medicine of preparation treatment acute bacillary dysentery of the described Chinese medicine composition.
The pharmacology of the present invention main raw material of Chinese medicine used is as follows:
Herba Portulacae: nature and flavor with return through acid, cold. Return liver, large intestine channel. Function with cure mainly: heat-clearing and toxic substances removing, cooling blood for hemostasis, dysentery relieving. For toxic-heat and blood stasis, carbuncle furuncle, eczema, erysipelas, snake bite and insect sting, have blood in stool, hemorrhoidal bleeding, metrostaxis.
Semen Momordicae: base: for the seed of Cucurbitaceae Momordica plant wood nose. Composition: seed containing saponin: fixed I and I c of Semen Momordicae saponin �� and II Semen Momordicae, albumen and peptides: Semen Momordicae glycoprotein S, N-powder stamen Buxus sinica (Rehd.et Wils.) alcohol pentapeptide, momordic acid you, oleanolic acid, sterol, Cochinchinin etc. The property of medicine: bitter, micro-sweet, temperature, poisonous. Return liver, spleen, stomach warp. Function cures mainly: dispersing swelling and dissipating binds, chases after wind pain relieving. Cure mainly carbuncle, furuncle, innominate toxic swelling, hemorrhoid, acne, black dry black once, mastitis, tuberculous lymphadenitis, dysentery, rheumatic arthralgia, muscle arteries and veins contracture, gingival swelling and pain.
The Radix Pulsatillae: nature and flavor with return through: bitter, cold. Return stomach, large intestine channel. Function with cure mainly: heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery. For toxic-heat and blood stasis, pudendal pruritus leukorrhagia.
The Radix Aucklandiae: nature and flavor with return through: pungent, bitter, temperature. Return spleen, stomach, large intestine, three burnt, gallbladder meridians. Function with cure mainly: promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion. For the breast side of body, abdominal distention, weight after dysentery, food stagnation does not disappear, anorexia. Radix Aucklandiae (roasted) reality intestinal antidiarrheal. For stomachache of having loose bowels.
Herba Polygoni Capitati: base: for the herb of polygonaceae plant Herba Polygoni Capitati. Chemical analysis: Herba Polygoni Capitati herb is containing benzaldehyde, acetic acid, 24-hydroxyl lignocerane-3-ketone, 29-hydroxyl nonacosane-3-ketone, cupreol, gallic acid. Nature and flavor: bitter; Pungent; Cool in nature. Function cures mainly: clearing away heat-damp and promoting diuresis; Promoting blood circulation and stopping pain. Main dysentery; Pyelonephritis; Cystitis; Lithangiuria; Rheumatalgia; Traumatic injury; Mumps; Skin infection; Eczema.
Herba Zornia Diphyllae: base: for the herb of pulse family Herba Zornia Diphyllae platymiscium Herba Zornia Diphyllae. Composition: herb is containing coumarin. The property of medicine: bitter, sweet, cool. Function cures mainly: heat-clearing and toxic substances removing, cool the blood dissipate blood stasis, and dehumidify diuresis. Curing mainly anemopyretic cold, pharyngalgia, skin infection swells and ache, venom, and jaundice is had loose bowels, dysentery, infantile malnutrition.
Cortex Corni macrophyllae: base; Bark is obtained for Cornaceae fogfruit Lignum corni macrophyllae. The property of medicine: bitter, flat. Function cures mainly: dispelling wind and removing obstruction in the collateral, dampness removing antidiarrheal. Curing mainly bones and muscles pain, quadriplegia, dysentery, watery diarrhea is suffered from abdominal pain.
Graperoot: base: for the root of Berberidaceae Mahonia fortunei (Lindl.) Fedde platymiscium Mahonia bealei (Fort.) Carr., mahonia fortuneiFedde. Composition: 1. Mahonia bealei (Fort.) Carr. root is containing alkaloid: berberine. 2. south China graperoot is containing alkaloid: isotetrandrine, berberine, palmatine, jateorhizine and berbamine. The property of medicine: " Traditional Chinese Medicine in Sichuan will " nineteen sixty version: " cold in nature, bitter in the mouth. " function cures mainly: heat clearing and damp drying, removing toxic substances and promoting subsidence of swelling. Cure mainly hygropyretic dysentery, diarrhoea, jaundice, pulmonary tuberculosis hemoptysis, throat pain, toothache, conjunctival congestion and swelling pain, traumatic injury, skin infection, eczema, scald etc. Compatibility and incompatibility of drugs: the careful clothes of Deficiency and coldness of spleen and stomach person.
Flos Lonicerae: sweet in the mouth, micro-hardship, cold nature. Having heat-clearing and toxic substances removing, expelling pathogenic factors from the exterior is gone out, effect of stomach function regulating preventing or arresting vomiting, stops up resistance, disorder of stomach-QI, fever and irritability for pathogenic heat.
Acute bacillary dysentery QiReLiShi herbs composite formula science provided by the invention, preparation method is simple, easy to use. In addition, its excellent part is also manifested by:
1, the present invention is directed to acute bacillary dysentery, have effect of clearing away heat-damp and promoting diuresis, removing toxic substances removing heat from blood;
2, selected medical material in the present invention, cheap, does not increase the financial burden of patient;
3, each dosage form meets theory of Chinese medical science, can play the curative effect of medicine to greatest extent.
Detailed description of the invention
Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.
Embodiment 1 acute bacillary dysentery QiReLiShi herbs compositions, is mainly prepared from by following bulk drugs: Herba Portulacae 18g, Semen Momordicae 6g, Radix Pulsatillae 10g, Radix Aucklandiae 5g, Herba Polygoni Capitati 15g, Herba Zornia Diphyllae 6g, Cortex Corni macrophyllae 3g, graperoot 5g, Flos Lonicerae 15g. The preparation method of above-mentioned Chinese medicine composition decoction is:
(1) Semen Momordicae being removed impurity, be ground into powder, cross 40 mesh sieves, be then placed in pot, the dry stir-fry of little fire, to there being fragrance to blow out, is taken out standby;
(2) taking Cortex Corni macrophyllae addition rice vinegar to mix thoroughly, vexed moisture-inhibiting is moistened, and the time is 15 minutes, after vinegar is sucked, puts into container, slow fire heating fried dry, and taking-up is dried in the air cool standby;
(3) Herba Portulacae, the Radix Pulsatillae, the Radix Aucklandiae, graperoot rinse shave are placed in marmite, and add water retting 1 hour, the water yield is 6 times of medical material weight, after intense fire is boiled, add step (1) (2) gains and the Herba Polygoni Capitati cleaned, Herba Zornia Diphyllae, Flos Lonicerae, turn little fire to decoct 40 minutes, filter;
(4) recrement boiling again, filters, merges with step (3) gained filtrate and be concentrated into 1/2nd of original volume, and sterilizing encapsulation obtains Chinese medicine composition decoction.
Embodiment 2 acute bacillary dysentery QiReLiShi herbs compositions, is mainly prepared from by following bulk drugs: Herba Portulacae 40g, Semen Momordicae 9g, Radix Pulsatillae 20g, Radix Aucklandiae 15g, Herba Polygoni Capitati 25g, Herba Zornia Diphyllae 12g, Cortex Corni macrophyllae 10g, graperoot 12g, Flos Lonicerae 25g. The manufacture method of above-mentioned Chinese medicine composition thick paste agent is:
(1) Semen Momordicae being removed impurity, be ground into powder, cross 50 mesh sieves, be then placed in pot, the dry stir-fry of little fire, to there being fragrance to blow out, is taken out standby;
(2) taking Cortex Corni macrophyllae addition rice vinegar to mix thoroughly, vexed moistening, the time is 18 minutes, after vinegar is sucked, puts into container, slow fire heating fried dry, and taking-up is dried in the air cool standby;
(3) Herba Portulacae, the Radix Pulsatillae, the Radix Aucklandiae, graperoot rinse shave are placed in marmite, and add water retting 2 hours, after intense fire is boiled, add step (1) (2) gains and the Herba Polygoni Capitati cleaned, Herba Zornia Diphyllae, Flos Lonicerae, turn little fire to decoct 50 minutes, filter;
(4) recrement boiling again, the persistent period is 30 minutes, filter merge with step (3) gained filtrate, be concentrated into relative density 1.25(60 DEG C) thick paste, sterilizing, obtain thick paste agent.
Instructions of taking: twice daily, once two soup ladles, warm boiled water, five days is a course for the treatment of.
Model case: xxx, male, 31 years old. Main suit: heating, dizzy, stomachache two days, with bloody purulent stool; History of present illness: suddenly heating of returning after patient's tourism, fear cold, without shiver with cold, hypogastric region rest pain and diarrhoea, a small amount of bloody purulent stool, absence of nausea and vomiting symptom again simultaneously. Diagnosis is: acute bacillary dysentery.
Taking the gained traditional Chinese medicine thick paste agent of this example, after three days, patient's phenomenon of suffering from diarrhoea substantially is alleviated, continue to take two the course for the treatment of order, patient's discomfort disease disappears, and physical recovery is healthy, and self-induction is fully recovered.
Embodiment 3 acute bacillary dysentery QiReLiShi herbs compositions, is mainly prepared from by following bulk drugs: Herba Portulacae 20g, Semen Momordicae 7g, Radix Pulsatillae 12g, Radix Aucklandiae 8g, Herba Polygoni Capitati 18g, Herba Zornia Diphyllae 8g, Cortex Corni macrophyllae 5g, graperoot 7g, Flos Lonicerae 18g. The manufacture method of above-mentioned Chinese medicine composition pill is:
(1) Semen Momordicae being removed impurity, be ground into powder, cross 80 mesh sieves, be then placed in pot, the dry stir-fry of little fire, to there being fragrance to blow out, is taken out standby;
(2) take Cortex Corni macrophyllae add rice vinegar mix thoroughly, vexed moistening, the time is 18 minutes, after vinegar is sucked, puts into container, slow fire heating fried dry, take out dry in the air cool grind to form end standby;
(3) Herba Portulacae, the Radix Pulsatillae, the Radix Aucklandiae, graperoot rinse shave are placed in marmite, and add water retting 2 hours, after intense fire is boiled, add clean Herba Polygoni Capitati, Herba Zornia Diphyllae, Flos Lonicerae, turn little fire decoct 50 minutes, filter;
(4) by step (1), (2), (3) gained medicated powder and filtrate mix homogeneously, adding refined honey according to the ratio of 4:1, make and have plastic ball bar, sterilizing segmentation is packaged to be the pill of 0.5g/.
Instructions of taking: every day, sooner or later respectively once once two ball, five days was a course for the treatment of.
Model case: xxx, women, 5 years old. Medical history: because eating unclean fruit by mistake, heating, nausea and vomiting symptom abdominal pain diarrhea, stool containing pus and blood occur, is acute bacillary dysentery through hospital diagnosis. Taking this example gained medicine pill, patient suffers from diarrhoea in three days and stops, and pain phenomenon alleviates, and other uncomfortable diseases alleviate, and continue to strengthen a course for the treatment of, and health is got well substantially, goes each physical and chemical index of examination in hospital all qualified.
Embodiment 4 acute bacillary dysentery QiReLiShi herbs compositions, is mainly prepared from by following bulk drugs: Herba Portulacae 38g, Semen Momordicae 8g, Radix Pulsatillae 18g, Radix Aucklandiae 12g, Herba Polygoni Capitati 22g, Herba Zornia Diphyllae 10g, Cortex Corni macrophyllae 8g, graperoot 10g, Flos Lonicerae 22g. The manufacture method of above-mentioned Chinese medicinal composition granules is:
(1) Semen Momordicae being removed impurity, be ground into powder, cross 80 mesh sieves, be then placed in pot, the dry stir-fry of little fire, to there being fragrance to blow out, is taken out standby;
(2) take Cortex Corni macrophyllae add rice vinegar mix thoroughly, vexed moistening, the time is 18 minutes, after vinegar is sucked, puts into container, slow fire heating fried dry, take out dry in the air cool grind to form end standby;
(3) Herba Portulacae, the Radix Pulsatillae, the Radix Aucklandiae, graperoot rinse shave are placed in marmite, and add water retting 2 hours, after intense fire is boiled, add clean Herba Polygoni Capitati, Herba Zornia Diphyllae, Flos Lonicerae, turn little fire decoct 50 minutes, filter;
(4) recrement boiling again, filter, be combined and concentrated to relative density 1.20(60 DEG C with step (3) gained filtrate) thick paste, add step (1) (2) gained medicated powder, mix homogeneously, make the soft material that light pressure then dissipates, be pressed through 14-18 mesh sieve, dry at 70 DEG C and obtain Chinese medicine granules.
Instructions of taking: every day, sooner or later respectively once once a bag, warm boiled water, five days was a course for the treatment of.
Model case: xxx, women, 58 years old. Medical history: patient generated heat suddenly before two days diarrhoea, and about 20 minutes once, and a small amount of pus and blood in just, vomiting phenomenon, lassitude, limbs fatigue once occurred in period, was toxic type bacillary dysentery through hospital diagnosis. Taking this example gained Chinese medicine granules, after two courses for the treatment of, patient defecates normally, and malaise symptoms eliminates, and self-induction is fully recovered.
Embodiment 5 acute bacillary dysentery QiReLiShi herbs compositions, is mainly prepared from by following bulk drugs: Herba Portulacae 29g, Semen Momordicae 7.5g, Radix Pulsatillae 15g, Radix Aucklandiae 10g, Herba Polygoni Capitati 20g, Herba Zornia Diphyllae 9g, Cortex Corni macrophyllae 6.5g, graperoot 8.5g, Flos Lonicerae 20g. The manufacture method of above-mentioned Chinese medicine composition decoction is:
(1) Semen Momordicae being removed impurity, be ground into powder, cross 50 mesh sieves, be then placed in pot, the dry stir-fry of little fire, to there being fragrance to blow out, is taken out standby;
(2) taking Cortex Corni macrophyllae addition rice vinegar to mix thoroughly, vexed moisture-inhibiting is moistened, and the time is 18 minutes, after vinegar is sucked, puts into container, slow fire heating fried dry, and taking-up is dried in the air cool standby;
(3) Herba Portulacae, the Radix Pulsatillae, the Radix Aucklandiae, graperoot rinse shave are placed in marmite, and add water retting 2 hours, the water yield is 7 times of medical material weight, after intense fire is boiled, add step (1) (2) gains and the Herba Polygoni Capitati cleaned, Herba Zornia Diphyllae, Flos Lonicerae, turn little fire to decoct 50 minutes, filter;
(4) recrement boiling again, filters, merges with step (3) gained filtrate and be concentrated into 1/2nd of original volume, and sterilizing encapsulation obtains Chinese medicine composition decoction.
Instructions of taking: every day, sooner or later respectively once a 150-200ml, five days was a course for the treatment of.
The clinical practice of test example 1 embodiment 5 gained Chinese medicine composition decoction: foundation hospital outpatient case history, screening acute bacillary dysentery patient 389 example, wherein women 217 example, male 172 example, oldest 70 years old, minimum 5 years old, 35.6 years old mean age. Before test, this crowd is carried out Continuous Observation, record symptom and change, is randomly divided into two groups, experimental group (N=254); Matched group (N=135).
Experimental group takes embodiment 5 products obtained therefrom, and sooner or later respectively once, each 150-200ml, five days is a course for the treatment of; Matched group uses other conventional method (norfloxacin, bactrim, gentamycin or transfusion).
Curative effect determinate standard: cure: malaise symptoms eliminates, and physical and chemical index is normal; Effective: cardinal symptom substantially eliminates, main physical and chemical index makes moderate progress; Invalid: main physical and chemical index is front with treatment unchanged. Total effective rate=cure rate+effective percentage.
Clinical effectiveness: after taking two courses for the treatment of, experimental group: cure rate 81.1%(206/254), effective percentage 16.9%(43/254) and, inefficiency 2%(5/254); Matched group: cure rate 60%(81/135), effective percentage 24.4%(33/135), inefficiency 15.6%(21/135)
By observing the rehabilitation situation of two groups of acute bacillary dysentery patients, it has been found that embodiment 5 products obtained therefrom is better than conventional products, and advantage shows that administration time is short, cure rate is high. The total effective rate of experimental group is 98%, hence it is evident that be better than the 84.4% of matched group.
The present invention with heat-clearing and toxic substances removing, regulate the flow of vital energy and blood is for the rule for the treatment of, multiple medical material synergistic combination, treats acute bacillary dysentery targetedly, then the effect such as the dampness removing antidiarrheal adding the circulation of qi promoting spleen invigorating of other accessory drugss such as Radix Aucklandiae, Cortex Corni macrophyllae, effect is notable, and its total effective rate of clinical trial certificate can reach 98%.
It should be pointed out that, the detailed description of the invention more representational example that is the present invention, it is clear that technical scheme is not limited to above-described embodiment, it is also possible to have many variations. Those of ordinary skill in the art, with the present invention undoubted the obtaining of clearly disclosed or according to file written description, be all considered as this patent scope of the claimed.

Claims (3)

1. acute bacillary dysentery QiReLiShi herbs compositions, it is characterised in that be mainly prepared from by following bulk drugs, be weight portion: Herba Portulacae 18; Semen Momordicae 6; The Radix Pulsatillae 10; The Radix Aucklandiae 5; Herba Polygoni Capitati 15; Herba Zornia Diphyllae 6; Cortex Corni macrophyllae 3; Graperoot 5; Flos Lonicerae 15.
2. the preparation method of acute bacillary dysentery QiReLiShi herbs compositions decoction as claimed in claim 1, it is characterised in that step is:
(1) Semen Momordicae being removed impurity, be ground into powder, cross 40-60 mesh sieve (preferably 50 order), be then placed in pot, the dry stir-fry of little fire, to there being fragrance to blow out, is taken out standby;
(2) taking Cortex Corni macrophyllae addition rice vinegar to mix thoroughly, vexed moisture-inhibiting is moistened, and the time is 15-20 minute (being preferably 18 minutes), after vinegar is sucked, puts into container, slow fire heating fried dry, and taking-up is dried in the air cool standby;
(3) Herba Portulacae, the Radix Pulsatillae, the Radix Aucklandiae, graperoot rinse shave are placed in marmite, and add water retting 1-3 hour (preferably 2 hours), after intense fire is boiled, add step (1) (2) gains and the Herba Polygoni Capitati cleaned, Herba Zornia Diphyllae, Flos Lonicerae, turn little fire and decoct 40-60 minute (preferably 50 minutes), filter;
(4) recrement boiling again, filters, merges with step (3) gained filtrate and be concentrated into 1/2nd of original volume, and sterilizing encapsulation obtains Chinese medicine composition decoction.
3. preparation method as claimed in claim 2, it is characterised in that 6-8 times (preferably 7 times) that amount is medical material weight that step (3) adds water.
CN201610095594.8A 2014-10-28 2014-10-28 Composition for treating acute bacillary dysentery Withdrawn CN105616559A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410582702.5A CN104352584A (en) 2014-10-28 2014-10-28 Traditional Chinese medicine composition with functions of clearing heat and promoting diuresis for acute bacillary dysentery and preparation method

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201410582702.5A Division CN104352584A (en) 2014-10-28 2014-10-28 Traditional Chinese medicine composition with functions of clearing heat and promoting diuresis for acute bacillary dysentery and preparation method

Publications (1)

Publication Number Publication Date
CN105616559A true CN105616559A (en) 2016-06-01

Family

ID=52519957

Family Applications (4)

Application Number Title Priority Date Filing Date
CN201410582702.5A Pending CN104352584A (en) 2014-10-28 2014-10-28 Traditional Chinese medicine composition with functions of clearing heat and promoting diuresis for acute bacillary dysentery and preparation method
CN201610095593.3A Withdrawn CN105616558A (en) 2014-10-28 2014-10-28 Heat-clearing and diuresis-promoting ointment for acute bacterial dysentery
CN201610095591.4A Withdrawn CN105560410A (en) 2014-10-28 2014-10-28 Granules for treating acute bacillary dysentery
CN201610095594.8A Withdrawn CN105616559A (en) 2014-10-28 2014-10-28 Composition for treating acute bacillary dysentery

Family Applications Before (3)

Application Number Title Priority Date Filing Date
CN201410582702.5A Pending CN104352584A (en) 2014-10-28 2014-10-28 Traditional Chinese medicine composition with functions of clearing heat and promoting diuresis for acute bacillary dysentery and preparation method
CN201610095593.3A Withdrawn CN105616558A (en) 2014-10-28 2014-10-28 Heat-clearing and diuresis-promoting ointment for acute bacterial dysentery
CN201610095591.4A Withdrawn CN105560410A (en) 2014-10-28 2014-10-28 Granules for treating acute bacillary dysentery

Country Status (1)

Country Link
CN (4) CN104352584A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106421164A (en) * 2016-11-02 2017-02-22 杨均初 Traditional Chinese medicine composition for treating dysentery and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101167828A (en) * 2007-09-29 2008-04-30 宋世洲 Traditional Chinese medicine for treating acute bacterial dysentery

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101167828A (en) * 2007-09-29 2008-04-30 宋世洲 Traditional Chinese medicine for treating acute bacterial dysentery

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106421164A (en) * 2016-11-02 2017-02-22 杨均初 Traditional Chinese medicine composition for treating dysentery and preparation method thereof

Also Published As

Publication number Publication date
CN105560410A (en) 2016-05-11
CN105616558A (en) 2016-06-01
CN104352584A (en) 2015-02-18

Similar Documents

Publication Publication Date Title
CN104208245B (en) Tinea manus and pedis Traditional Chinese medicine medicated bath and preparation method
CN105616559A (en) Composition for treating acute bacillary dysentery
CN105456957A (en) Traditional Chinese medicine composition for treating bromhidrosis
CN104873730A (en) Traditional Chinese medicine for treating acute mastitis with liver-qi stagnancy
CN105663283A (en) Pills for treating acute bacterial dysentery
CN105853843A (en) Pharmaceutical composition for clinical pediatric wound care and preparation method of pharmaceutical composition for clinical pediatric wound care
CN105194496A (en) Traditional Chinese medicine composition for mainly treating bone tuberculosis and preparation method
CN104189514A (en) Lymphatic tuberculosis resolving hard lump and eliminating phlegm preparation and preparation method thereof
CN105055840A (en) Drug for treating arrhythmia and preparation method thereof
CN104971157A (en) Externally applied powder for treating beriberi and preparation method
CN104758638A (en) Traditional Chinese medicine composition for treating gallstone
CN104547565A (en) Traditional Chinese medicine for treating diabetic peripheral neuropathy
CN103655935A (en) Traditional Chinese medicine composition for treating hepatitis B
CN106309874A (en) Traditional Chinese medicine capsules for treating palmar peeling
CN106237046A (en) A kind of Chinese medicinal capsule for treating exfoliative keratolysis
CN106421508A (en) Traditional Chinese medicine composition for treating heat-type asthma
CN105055959A (en) Traditional Chinese medicine for treating blood-heat bleeding type epidemic jaundice
CN105194493A (en) Preparation for treating epilepsy and preparation method
CN104383291A (en) Vital energy regulating and blood conditioning preparation for treating diarrhea and preparation method thereof
CN105596828A (en) Preparation for treating gonarthromeningitis and preparation method
CN104887865A (en) Traditional Chinese medicine composition for treating gout
CN107789470A (en) A kind of Chinese medicinal ointment for being used to treat fingers and palms decortication
CN104840733A (en) Traditional Chinese medicine preparation for treating anemia and preparation method of traditional Chinese medicine preparation
CN105327028A (en) Preparation for treating uremia and preparation method
CN105213838A (en) A kind of preparation and method for making of preventing and treating spontaneous perspiration

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information

Address after: Chenggong Longcheng Street 650000 Yunnan city of Kunming province No. 81

Applicant after: Wang Hui

Address before: 250000 Shandong Province Flyover District of Ji'nan City Road 32.

Applicant before: Wang Hui

CB02 Change of applicant information
WW01 Invention patent application withdrawn after publication

Application publication date: 20160601

WW01 Invention patent application withdrawn after publication