CN105560410A - Granules for treating acute bacillary dysentery - Google Patents

Granules for treating acute bacillary dysentery Download PDF

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CN105560410A
CN105560410A CN201610095591.4A CN201610095591A CN105560410A CN 105560410 A CN105560410 A CN 105560410A CN 201610095591 A CN201610095591 A CN 201610095591A CN 105560410 A CN105560410 A CN 105560410A
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bacillary dysentery
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graperoot
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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Abstract

The invention discloses granules for treating the acute bacillary dysentery. The granules are mainly prepared from, by weight, 18-40 parts of purslane, 6-9 parts of momordica cochinchinensis, 10-20 parts of Chinese pulsatilla roots, 5-15 parts of costusroot, 15-25 parts of capitate knotweed herb, 6-12 parts of roots of twinleaf zzornia, 3-10 parts of largeleaf dogwood bark, 5-12 parts of graperoot and 15-25 parts of honeysuckle. The composition is scientific in formula, simple in preparation method and convenient to use and has functions of cleaning heat, promoting diuresis, removing toxicity and cooling blood for treating the acute bacillary dysentery.

Description

A kind of granule for the treatment of acute bacillary dysentery
Divisional application, original applying number 2014105827025, applying date 2014.10.28, title acute bacillary dysentery QiReLiShi herbs compositions and preparation method.
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of acute bacillary dysentery QiReLiShi herbs compositions and preparation method.
Background technology
Bacillary dysentery is the more common a kind of infectious intestinal disease of children's, caused by dysentery bacterium.Clinically with heating, stomachache, diarrhoea, tenesmus and arrange the loose stool of mucous, pus and blood for its cardinal symptom.Clinically course of disease person within 2 months is called acute bacillary dysentery, point 3 types, i.e. plain edition, light-duty and toxic type.Plain edition shows as heating of feeling cold, stomachache, diarrhoea, companion's tenesmus.Stomachache, based on left lower quadrant, in paroxysmal, alleviates greatly after an action of the bowels.Stool every day tens times to tens times, typical person is that mucus bloody purulent stool is with tenesmus sense.Toxic type acute bacillary dysentery onset is hurried, and change rapidly, can show as high heat, headache, vomiting, irritated, drowsiness, even blood pressure drops, consciousness changing.Current treatment acute bacillary dysentery is generally by having Western medicine, and the antidiarrheal effect of Western medicine is fast but can cause injury in various degree to stomach, liver, and side effect is larger.
Publication No. CN103417671A(application number 201210175550.8) Chinese patent literature disclose a kind of Chinese medicine for the treatment of acute bacillary dysentery, be made up of the component of following weight portion: Semen Plantaginis 40-50 gram, Radix Sophorae Flavescentis 20-40 gram, Fructus Crataegi (parched to brown) 15-25 gram, grind to the powder altogether.Publication No. CN102772598A(application number 201210295050.8) Chinese patent literature disclose a kind of Chinese medicine for the treatment of bacillary dysentery.The Chinese medicine of this treatment bacillary dysentery with Rhizoma Acori Graminei, Spica Prunellae, Folium Isatidis, the Radix Aucklandiae, Fructus Crataegi, Herba Polygoni Avicularis, Flos Narcissi chinensis, Flos Sophorae, Herba Portulacae, Flos Hibisci, Herba Agrimoniae, Cortex Pini Massonianae, Herba Salviae Chinensis, flower of poplar, Radix Sanguisorbae and Flos Musae for raw material, formulated according to certain weight proportion.Publication No. CN103417590A(application number 201210182815.7) Chinese patent literature disclose a kind of Chinese medicine for the treatment of chronic bacillary dysentery, it is characterized in that it is made up of the component of following weight portion: Pericarpium Granati 50 grams, Radix Angelicae Sinensis 15 grams uses clear water decoction, and once clothes go down.
Now for the treatment of dysentery mainly based on doctor trained in Western medicine, therapeutic effect fast but side effect is very big, easily produce injury to liver, Chinese traditional treatment of comparing is more suitable for, but because of traditional Chinese medical science theory different, effect difference is comparatively large, so also require further study.
Summary of the invention
For the problem of prior art, the object of this invention is to provide a kind of Be very effective, take the Chinese medicine composition of the treatment acute bacillary dysentery that safety has no side effect.
Technical scheme of the present invention is:
Acute bacillary dysentery QiReLiShi herbs compositions, is prepared from primarily of following bulk drugs, is weight portion: Herba Portulacae 18-40; Semen Momordicae 6-9; Radix Pulsatillae 10-20; Radix Aucklandiae 5-15; Herba Polygoni Capitati 15-25; Herba Zornia Diphyllae 6-12; Cortex Corni macrophyllae 3-10; Graperoot 5-12; Flos Lonicerae 15-25.
Preferred scheme is: Herba Portulacae 20-38; Semen Momordicae 7-8; Radix Pulsatillae 12-18; Radix Aucklandiae 8-12; Herba Polygoni Capitati 18-22; Herba Zornia Diphyllae 8-10; Cortex Corni macrophyllae 5-8; Graperoot 7-10; Flos Lonicerae 18-22.
What be more preferably is: Herba Portulacae 29, Semen Momordicae 7.5, the Radix Pulsatillae 15, the Radix Aucklandiae 10, Herba Polygoni Capitati 20, Herba Zornia Diphyllae 9, Cortex Corni macrophyllae 6.5, graperoot 8.5, Flos Lonicerae 20.
Present invention also offers and this Chinese medicine composition is made pharmaceutically acceptable decoction, thick paste agent, pill and granule.
The preparation method of described decoction is:
(1) Semen Momordicae is removed impurity, be ground into powder, cross 40-60 mesh sieve (preferably 50 orders), then put into pot, little fire is done stir-fry and is blown out to there being fragrance, takes out for subsequent use;
(2) get Cortex Corni macrophyllae to add rice vinegar and mix thoroughly, vexed moisture-inhibiting profit, the time is 15-20 minute (being preferably 18 minutes), after vinegar is sucked, puts into container, slow fire heating fried dry, take out dry in the air cool for subsequent use;
(3) Herba Portulacae, the Radix Pulsatillae, the Radix Aucklandiae, graperoot rinse shave are placed in marmite, and add water retting 1-3 hour (preferably 2 hours), after intense fire is boiled, add step (1) (2) gains and the Herba Polygoni Capitati cleaned, Herba Zornia Diphyllae, Flos Lonicerae, turn little fire to decoct 40-60 minute (preferably 50 minutes), filter;
(4) recrement decocts with water again, filters, merges be concentrated into 1/2nd of original volume with step (3) gained filtrate, and sterilizing encapsulation obtains Chinese medicine composition decoction.
The preparation method of described decoction, the amount that step (3) adds water is 6-8 times (preferably 7 times) of medical material weight.
The preparation method of described thick paste is:
(1) Semen Momordicae is removed impurity, be ground into powder, cross 40-60 mesh sieve (preferably 50 orders), then put into pot, little fire is done stir-fry and is blown out to there being fragrance, takes out for subsequent use;
(2) get Cortex Corni macrophyllae to add rice vinegar and mix thoroughly, vexed moistening, the time is 15-20 minute (preferably 18 minutes), after vinegar is sucked, puts into container, slow fire heating fried dry, take out dry in the air cool for subsequent use;
(3) Herba Portulacae, the Radix Pulsatillae, the Radix Aucklandiae, graperoot rinse shave are placed in marmite, and add water retting 1-3 hour (preferably 2 hours), after intense fire is boiled, add step (1) (2) gains and the Herba Polygoni Capitati cleaned, Herba Zornia Diphyllae, Flos Lonicerae, turn little fire and decoct 50 minutes, filter;
(4) recrement decocts with water again, and the persistent period is 30 minutes, filters and merges with step (3) gained filtrate, be concentrated into relative density 1.20-1.30(60 DEG C) thick paste of (preferably 1.25), sterilizing, obtains thick paste agent.
The preparation method of described pill is:
(1) Semen Momordicae is removed impurity, be ground into powder, cross 70-90 mesh sieve (preferably 80 orders), then put into pot, little fire is done stir-fry and is blown out to there being fragrance, takes out for subsequent use;
(2) get Cortex Corni macrophyllae to add rice vinegar and mix thoroughly, vexed moistening, the time is 15-20 minute (preferably 18 minutes), after vinegar is sucked, puts into container, slow fire heating fried dry, and it is for subsequent use to take out the cool end that grinds to form of drying in the air;
(3) Herba Portulacae, the Radix Pulsatillae, the Radix Aucklandiae, graperoot rinse shave are placed in marmite, and add water retting 1-3 hour (preferably 2 hours), after intense fire is boiled, add clean Herba Polygoni Capitati, Herba Zornia Diphyllae, Flos Lonicerae, turn little fire and decoct 50 minutes, filter;
(4) by step (1), (2), (3) gained medicated powder and filtrate mix homogeneously, add refined honey according to the ratio of 4:1, make and have plastic ball bar, sterilizing segmentation is packaged to be the pill of 0.5g/.
The preparation method of described granule is:
(1) Semen Momordicae is removed impurity, be ground into powder, cross 70-90 mesh sieve (preferably 80 orders), then put into pot, little fire is done stir-fry and is blown out to there being fragrance, takes out for subsequent use;
(2) get Cortex Corni macrophyllae to add rice vinegar and mix thoroughly, vexed moistening, the time is 15-20 minute (preferably 18 minutes), after vinegar is sucked, puts into container, slow fire heating fried dry, and it is for subsequent use to take out the cool end that grinds to form of drying in the air;
(3) Herba Portulacae, the Radix Pulsatillae, the Radix Aucklandiae, graperoot rinse shave are placed in marmite, and add water retting 1-3 hour (preferably 2 hours), after intense fire is boiled, add clean Herba Polygoni Capitati, Herba Zornia Diphyllae, Flos Lonicerae, turn little fire and decoct 50 minutes, filter;
(4) recrement decocts with water again, filter, merge with step (3) gained filtrate and be concentrated into relative density 1.18-1.21(60 DEG C) thick paste of (preferably Ei 1.20), add step (1) (2) gained medicated powder, mix homogeneously, make the soft material that light pressure is then loose, be pressed through 14-18 mesh sieve, dry at 70 DEG C and obtain Chinese medicine granules.
Present invention also offers the application of described Chinese medicine composition when preparing the medicine for the treatment of acute bacillary dysentery.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Herba Portulacae: nature and flavor with return through acid, cold.Return liver, large intestine channel.Function with cure mainly: heat-clearing and toxic substances removing, cooling blood for hemostasis, dysentery relieving.For toxic-heat and blood stasis, carbuncle furuncle, eczema, erysipelas, snake bite and insect sting, has blood in stool, hemorrhoidal bleeding, metrostaxis.
Semen Momordicae: base is former: be the seed of Cucurbitaceae Momordica plant wood nose.Composition: seed containing saponin: Semen Momordicae saponin Ⅰ and fixed I and I c of II Semen Momordicae, albumen and peptide class: Semen Momordicae glycoprotein S, N-powder stamen Buxus sinica (Rehd.et Wils.) alcohol pentapeptide, momordic acid you, oleanolic acid, sterol, Cochinchinin etc.The property of medicine: bitter, micro-sweet, temperature, poisonous.Return liver, spleen, stomach warp.Function cures mainly: dispersing swelling and dissipating binds, chases after wind pain relieving.Cure mainly carbuncle, furuncle, innominate toxic swelling, hemorrhoid, acne, black dry once black, mastitis, tuberculous lymphadenitis, dysentery, rheumatic arthralgia, the contracture of muscle arteries and veins, gingival swelling and pain.
The Radix Pulsatillae: nature and flavor with return through: bitter, cold.Return stomach, large intestine channel.Function with cure mainly: heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.For toxic-heat and blood stasis, pudendal pruritus leukorrhagia.
The Radix Aucklandiae: nature and flavor with return through: pungent, bitter, temperature.Return spleen, stomach, large intestine, three burnt, gallbladder meridians.Function with cure mainly: promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.For the breast side of body, abdominal distention, heavy after dysentery, food stagnation does not disappear, anorexia.The real intestinal antidiarrheal of Radix Aucklandiae (roasted).For stomachache of having loose bowels.
Herba Polygoni Capitati: base is former: be the herb of polygonaceae plant Herba Polygoni Capitati.Chemical analysis: Herba Polygoni Capitati herb contains benzaldehyde, acetic acid, 24-hydroxyl lignocerane-3-ketone, 29-hydroxyl nonacosane-3-ketone, cupreol, gallic acid.Nature and flavor: bitter; Pungent; Cool in nature.Function cures mainly: clearing away heat-damp and promoting diuresis; Promoting blood circulation and stopping pain.Main dysentery; Pyelonephritis; Cystitis; Lithangiuria; Rheumatalgia; Traumatic injury; Mumps; Skin infection; Eczema.
Herba Zornia Diphyllae: base is former: be the herb of pulse family Herba Zornia Diphyllae platymiscium Herba Zornia Diphyllae.Composition: herb is containing coumarin.The property of medicine: bitter, sweet, cool.Function cures mainly: heat-clearing and toxic substances removing, cool the blood dissipate blood stasis, dehumidifying diuresis.Cure mainly anemopyretic cold, pharyngalgia, skin infection swells and ache, venom, and jaundice is had loose bowels, dysentery, infantile malnutrition.
Cortex Corni macrophyllae: base is former; For Cornaceae Lai fogfruit Lignum corni macrophyllae obtains bark.The property of medicine: bitter, flat.Function cures mainly: dispelling wind and removing obstruction in the collateral, dampness removing antidiarrheal.Cure mainly bones and muscles pain, quadriplegia, dysentery, watery diarrhea is suffered from abdominal pain.
Graperoot: base is former: be the root of Berberidaceae Mahonia fortunei (Lindl.) Fedde platymiscium Mahonia bealei (Fort.) Carr., mahonia fortuneiFedde.Composition: 1. Mahonia bealei (Fort.) Carr. root is containing alkaloid: berberine.2. south China graperoot is containing alkaloid: isotetrandrine, berberine, palmatine, jateorhizine and berbamine.The property of medicine: " Traditional Chinese Medicine in Sichuan will " nineteen sixty version: " cold in nature, bitter in the mouth." function cures mainly: heat clearing and damp drying, removing toxic substances and promoting subsidence of swelling.Cure mainly hygropyretic dysentery, diarrhoea, jaundice, pulmonary tuberculosis hemoptysis, throat pain, toothache, conjunctival congestion and swelling pain, traumatic injury, skin infection, eczema, scald.Compatibility and incompatibility of drugs: the careful clothes of Deficiency and coldness of spleen and stomach person.
Flos Lonicerae: sweet in the mouth, micro-hardship, cold nature.Have heat-clearing and toxic substances removing, expelling pathogenic factors from the exterior is gone out, effect of stomach function regulating preventing or arresting vomiting, stops up resistance, disorder of stomach-QI, fever and irritability for pathogenic heat.
Acute bacillary dysentery QiReLiShi herbs composite formula science provided by the invention, preparation method is simple, easy to use.In addition, its excellent part also shows:
1, the present invention is directed to acute bacillary dysentery, have effect of clearing away heat-damp and promoting diuresis, removing toxic substances removing heat from blood;
2, selected medical material in the present invention, cheap, do not increase the financial burden of patient;
3, each dosage form meets theory of Chinese medical science, can play the curative effect of medicine to greatest extent.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
Embodiment 1 acute bacillary dysentery QiReLiShi herbs compositions, is prepared from primarily of following bulk drugs: Herba Portulacae 18g, Semen Momordicae 6g, Radix Pulsatillae 10g, Radix Aucklandiae 5g, Herba Polygoni Capitati 15g, Herba Zornia Diphyllae 6g, Cortex Corni macrophyllae 3g, graperoot 5g, Flos Lonicerae 15g.The preparation method of above-mentioned Chinese medicine composition decoction is:
(1) Semen Momordicae is removed impurity, be ground into powder, cross 40 mesh sieves, then put into pot, little fire is done stir-fry and is blown out to there being fragrance, takes out for subsequent use;
(2) get Cortex Corni macrophyllae to add rice vinegar and mix thoroughly, vexed moisture-inhibiting profit, the time is 15 minutes, after vinegar is sucked, puts into container, slow fire heating fried dry, take out dry in the air cool for subsequent use;
(3) Herba Portulacae, the Radix Pulsatillae, the Radix Aucklandiae, graperoot rinse shave are placed in marmite, and add water retting 1 hour, the water yield is 6 times of medical material weight, after intense fire is boiled, add step (1) (2) gains and the Herba Polygoni Capitati cleaned, Herba Zornia Diphyllae, Flos Lonicerae, turn little fire and decoct 40 minutes, filter;
(4) recrement decocts with water again, filters, merges be concentrated into 1/2nd of original volume with step (3) gained filtrate, and sterilizing encapsulation obtains Chinese medicine composition decoction.
Embodiment 2 acute bacillary dysentery QiReLiShi herbs compositions, is prepared from primarily of following bulk drugs: Herba Portulacae 40g, Semen Momordicae 9g, Radix Pulsatillae 20g, Radix Aucklandiae 15g, Herba Polygoni Capitati 25g, Herba Zornia Diphyllae 12g, Cortex Corni macrophyllae 10g, graperoot 12g, Flos Lonicerae 25g.The manufacture method of above-mentioned Chinese medicine composition thick paste agent is:
(1) Semen Momordicae is removed impurity, be ground into powder, cross 50 mesh sieves, then put into pot, little fire is done stir-fry and is blown out to there being fragrance, takes out for subsequent use;
(2) get Cortex Corni macrophyllae to add rice vinegar and mix thoroughly, vexed moistening, the time is 18 minutes, after vinegar is sucked, puts into container, slow fire heating fried dry, take out dry in the air cool for subsequent use;
(3) Herba Portulacae, the Radix Pulsatillae, the Radix Aucklandiae, graperoot rinse shave are placed in marmite, and add water retting 2 hours, after intense fire is boiled, add step (1) (2) gains and the Herba Polygoni Capitati cleaned, Herba Zornia Diphyllae, Flos Lonicerae, turn little fire and decoct 50 minutes, filter;
(4) recrement decocts with water again, and the persistent period is 30 minutes, filters and merges with step (3) gained filtrate, be concentrated into relative density 1.25(60 DEG C) thick paste, sterilizing, obtains thick paste agent.
Instructions of taking: twice daily, once two soup ladles, warm boiled water five days is a course for the treatment of.
Model case: xxx, male, 31 years old.Main suit: heating, dizzy, stomachache two days, with bloody purulent stool; History of present illness: suddenly heating of returning after patient's tourism, fear cold, without shiver with cold, hypogastric region rest pain and diarrhoea again simultaneously, a small amount of bloody purulent stool, absence of nausea and vomiting symptom.Be diagnosed as: acute bacillary dysentery.
Take the agent of this example gained traditional Chinese medicine thick paste, after three days, patient's phenomenon of suffering from diarrhoea obviously is alleviated, continue to take two the course for the treatment of order, the uncomfortable disease of patient disappears, and physical recovery is healthy, and self-induction is fully recovered.
Embodiment 3 acute bacillary dysentery QiReLiShi herbs compositions, is prepared from primarily of following bulk drugs: Herba Portulacae 20g, Semen Momordicae 7g, Radix Pulsatillae 12g, Radix Aucklandiae 8g, Herba Polygoni Capitati 18g, Herba Zornia Diphyllae 8g, Cortex Corni macrophyllae 5g, graperoot 7g, Flos Lonicerae 18g.The manufacture method of above-mentioned Chinese medicine composition pill is:
(1) Semen Momordicae is removed impurity, be ground into powder, cross 80 mesh sieves, then put into pot, little fire is done stir-fry and is blown out to there being fragrance, takes out for subsequent use;
(2) get Cortex Corni macrophyllae to add rice vinegar and mix thoroughly, vexed moistening, the time is 18 minutes, after vinegar is sucked, puts into container, slow fire heating fried dry, and it is for subsequent use to take out the cool end that grinds to form of drying in the air;
(3) Herba Portulacae, the Radix Pulsatillae, the Radix Aucklandiae, graperoot rinse shave are placed in marmite, and add water retting 2 hours, after intense fire is boiled, add clean Herba Polygoni Capitati, Herba Zornia Diphyllae, Flos Lonicerae, turn little fire and decoct 50 minutes, filter;
(4) by step (1), (2), (3) gained medicated powder and filtrate mix homogeneously, add refined honey according to the ratio of 4:1, make and have plastic ball bar, sterilizing segmentation is packaged to be the pill of 0.5g/.
Instructions of taking: every day, sooner or later respectively once once two balls five days were a course for the treatment of.
Model case: xxx, women, 5 years old.Medical history: because eating unclean fruit by mistake, occur heating, nausea and vomiting symptom, and abdominal pain diarrhea, stool containing pus and blood are acute bacillary dysentery through hospital diagnosis.Take this example gained medicine pill, patient suffers from diarrhoea in three days and stops, and pain phenomenon alleviates, and other uncomfortable diseases alleviate, and continue to strengthen a course for the treatment of, health is got well substantially, goes each physical and chemical index of examination in hospital all qualified.
Embodiment 4 acute bacillary dysentery QiReLiShi herbs compositions, is prepared from primarily of following bulk drugs: Herba Portulacae 38g, Semen Momordicae 8g, Radix Pulsatillae 18g, Radix Aucklandiae 12g, Herba Polygoni Capitati 22g, Herba Zornia Diphyllae 10g, Cortex Corni macrophyllae 8g, graperoot 10g, Flos Lonicerae 22g.The manufacture method of above-mentioned Chinese medicinal composition granules is:
(1) Semen Momordicae is removed impurity, be ground into powder, cross 80 mesh sieves, then put into pot, little fire is done stir-fry and is blown out to there being fragrance, takes out for subsequent use;
(2) get Cortex Corni macrophyllae to add rice vinegar and mix thoroughly, vexed moistening, the time is 18 minutes, after vinegar is sucked, puts into container, slow fire heating fried dry, and it is for subsequent use to take out the cool end that grinds to form of drying in the air;
(3) Herba Portulacae, the Radix Pulsatillae, the Radix Aucklandiae, graperoot rinse shave are placed in marmite, and add water retting 2 hours, after intense fire is boiled, add clean Herba Polygoni Capitati, Herba Zornia Diphyllae, Flos Lonicerae, turn little fire and decoct 50 minutes, filter;
(4) recrement decocts with water again, filter, merge with step (3) gained filtrate and be concentrated into relative density 1.20(60 DEG C) thick paste, add step (1) (2) gained medicated powder, mix homogeneously, make the soft material that light pressure is then loose, be pressed through 14-18 mesh sieve, dry at 70 DEG C and obtain Chinese medicine granules.
Instructions of taking: every day, sooner or later respectively once once a bag, warm boiled water five days was a course for the treatment of.
Model case: xxx, women, 58 years old.Medical history: patient generated heat suddenly before two days diarrhoea, and about 20 minutes once, a small amount of pus and blood just, period once occurred vomitting phenomenon, and lassitude, limbs fatigue are toxic type bacillary dysentery through hospital diagnosis.Take this example gained Chinese medicine granules, after two courses for the treatment of, patient defecates normally, and malaise symptoms is eliminated, and self-induction is fully recovered.
Embodiment 5 acute bacillary dysentery QiReLiShi herbs compositions, is prepared from primarily of following bulk drugs: Herba Portulacae 29g, Semen Momordicae 7.5g, Radix Pulsatillae 15g, Radix Aucklandiae 10g, Herba Polygoni Capitati 20g, Herba Zornia Diphyllae 9g, Cortex Corni macrophyllae 6.5g, graperoot 8.5g, Flos Lonicerae 20g.The manufacture method of above-mentioned Chinese medicine composition decoction is:
(1) Semen Momordicae is removed impurity, be ground into powder, cross 50 mesh sieves, then put into pot, little fire is done stir-fry and is blown out to there being fragrance, takes out for subsequent use;
(2) get Cortex Corni macrophyllae to add rice vinegar and mix thoroughly, vexed moisture-inhibiting profit, the time is 18 minutes, after vinegar is sucked, puts into container, slow fire heating fried dry, take out dry in the air cool for subsequent use;
(3) Herba Portulacae, the Radix Pulsatillae, the Radix Aucklandiae, graperoot rinse shave are placed in marmite, and add water retting 2 hours, the water yield is 7 times of medical material weight, after intense fire is boiled, add step (1) (2) gains and the Herba Polygoni Capitati cleaned, Herba Zornia Diphyllae, Flos Lonicerae, turn little fire and decoct 50 minutes, filter;
(4) recrement decocts with water again, filters, merges be concentrated into 1/2nd of original volume with step (3) gained filtrate, and sterilizing encapsulation obtains Chinese medicine composition decoction.
Instructions of taking: every day, sooner or later respectively once a 150-200ml five days was a course for the treatment of.
The clinical practice of test example 1 embodiment 5 gained Chinese medicine composition decoction: according to hospital outpatient case history, screening acute bacillary dysentery patient 389 example, wherein women 217 example, male 172 example, oldest 70 years old, minimum 5 years old, 35.6 years old mean age.Carry out Continuous Observation to this crowd before test, record symptom and change, be divided into two groups, experimental group (N=254) at random; Matched group (N=135).
Experimental group takes embodiment 5 products obtained therefrom, and sooner or later respectively once, each 150-200ml five days is a course for the treatment of; Matched group uses other conventional method (norfloxacin, bactrim, gentamycin or transfusion).
Curative effect determinate standard: cure: malaise symptoms is eliminated, and physical and chemical index is normal; Effective: cardinal symptom is eliminated substantially, main physical and chemical index makes moderate progress; Invalid: main physical and chemical index is front unchanged with treatment.Total effective rate=cure rate+effective percentage.
Clinical effectiveness: after taking two courses for the treatment of, experimental group: cure rate 81.1%(206/254), effective percentage 16.9%(43/254) and, inefficiency 2%(5/254); Matched group: cure rate 60%(81/135), effective percentage 24.4%(33/135), inefficiency 15.6%(21/135)
By observing the rehabilitation situation of two groups of acute bacillary dysentery patients, find that embodiment 5 products obtained therefrom is better than conventional products, advantage shows that administration time is short, and cure rate is high.The total effective rate of experimental group is 98%, is obviously better than 84.4% of matched group.
The present invention with heat-clearing and toxic substances removing, regulate the flow of vital energy and blood for the rule for the treatment of, multiple medical material synergistic combination, treats acute bacillary dysentery targetedly, then adds other accessory drugss as effects such as the circulation of qi promoting spleen invigorating of the Radix Aucklandiae, the dampness removing antidiarrheal of Cortex Corni macrophyllae, Be very effective, its total effective rate of clinical trial certificate can reach 98%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (2)

1. acute bacillary dysentery QiReLiShi herbs compositions, is characterized in that, is prepared from primarily of following bulk drugs, is weight portion: Herba Portulacae 38; Semen Momordicae 8; The Radix Pulsatillae 18; The Radix Aucklandiae 12; Herba Polygoni Capitati 22; Herba Zornia Diphyllae 10; Cortex Corni macrophyllae 8; Graperoot 10; Flos Lonicerae 22.
2. the preparation method of acute bacillary dysentery QiReLiShi herbs composition granule according to claim 1, is characterized in that,
(1) Semen Momordicae is removed impurity, be ground into powder, cross 70-90 mesh sieve (preferably 80 orders), then put into pot, little fire is done stir-fry and is blown out to there being fragrance, takes out for subsequent use;
(2) get Cortex Corni macrophyllae to add rice vinegar and mix thoroughly, vexed moistening, the time is 15-20 minute (preferably 18 minutes), after vinegar is sucked, puts into container, slow fire heating fried dry, and it is for subsequent use to take out the cool end that grinds to form of drying in the air;
(3) Herba Portulacae, the Radix Pulsatillae, the Radix Aucklandiae, graperoot rinse shave are placed in marmite, and add water retting 1-3 hour (preferably 2 hours), after intense fire is boiled, add clean Herba Polygoni Capitati, Herba Zornia Diphyllae, Flos Lonicerae, turn little fire and decoct 50 minutes, filter;
(4) recrement decocts with water again, filter, merge with step (3) gained filtrate and be concentrated into relative density 1.18-1.21(60 DEG C) thick paste of (preferably 1.20), add step (1) (2) gained medicated powder, mix homogeneously, make the soft material that light pressure is then loose, be pressed through 14-18 mesh sieve, dry at 70 DEG C and obtain Chinese medicine granules.
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