CN101518600B - Chinese medicinal composition for treating bacterial or fungal dermatosis and preparation method thereof - Google Patents

Abstract

The invention discloses a Chinese medicinal composition for treating bacterial or fungal dermatosis and a preparation method thereof. An internal medicine comprises: 10 to 20 portions of danshen roots, 10 to 20 portions of suberect spatholobus stems, 10 to 20 portions of Chinese trumpetcreeper flowers, 10 to 20 portions of Chinese angelica, 10 to 20 portions of membranous milkvetch roots, 10 to 20portions of moutan barks, 10 to 20 portions of peach seeds, 10 to 20 portions of honeysuckle flowers, and 10 to 20 portions of philippine violet herbs; and an external medicine comprises: 10 to 30 po rtions of common cnidium fruits, 10 to 30 portions of natural indigo, 10 to 30 portions of spreading hedyotis herbs, 10 to 30 portions of belvedere fruits, 10 to 30 portions of dictamnus, 10 to 30 portions of heartleaf houttuynia herbs, 5 to 10 portions of Chinese wolfsbane, 10 to 30 portions of sessile stemona roots, 10 to 30 portions of parslane herbs, 10 to 30 portions of lightyellow sophora roots, 10 to 30 portions of sinkiang arnebia roots, 10 to 30 portions of dried alum, and 10 to 30 portions of cinnamon. The composition and the preparation method scientifically combine the effective components of various medicaments, and the composition is a medicament having the advantages of quick response, little side effect and strong bacteria restraint performance.

Description

A kind of Chinese medicine composition for the treatment of antibacterial or dermatomycosis and preparation method thereof

Technical field

The present invention relates to contain medicinal preparation that derives from plant, animal or mineral component and preparation method thereof, particularly a kind of Chinese medicine composition for the treatment of antibacterial or dermatomycosis and preparation method thereof.

Background technology

Antibacterial or dermatomycosis are a kind of anaphylaxis dermatosis, and be clinical common.Antibacterial or dermatomycosis, eczema and dermatitis, dermatosiss such as tinea class are common frequently-occurring diseases, diseases such as particularly obstinate dermatosis, eczema are many to be cardinal symptom very to itch, scratch repeatedly and can make the skin diabrosis, tissue infiltration oozes out, and skin turgor brings bigger misery to the patient.

Antibacterial or dermatomycosis are after acute attack, and be red and swollen and ooze out and alleviate, and enters the subacute stage, and pimple and a small amount of papulovesicle can be arranged, and is dim redness, and squama and slight the infiltration are arranged.Chronic bacterial or dermatomycosis often being formed by the delay of acute and subacute stage, or it is promptly very not serious to begin inflammation certainly, on the dim erythema pimple is arranged, scratch and squama.The pars affecta skin plumpness, rough surface is lichenification, has pigmentation or partial pigment to go down etc., and is heavy when light during the state of an illness, the continuity several months or more of a specified duration.

Traditional Chinese medical science general designation dermatosis is " eczema of lower limb ".The cause of disease is an intemperance of taking food, is addicted to drink or the pungent raw meat of surfeit starts the product of wind, injures taste, and spleen loses strong far away, causes retention of damp-heat in the interior, diseases caused by exogenous pathogenic factor rheumatism pathogenic heat again, and inside and outside two heresies are fought mutually, fill in space between skin and muscles, soak into skin and send out and be primary disease.Or because of physical weakness, the spleen being blocked by dampness, failure of skin and muscle to be nourished, or accumulate for a long time because of damp and hot, consumption impairment of YIN blood, wind is given birth in dryness-transformation, and the hyperamization wind syndrome caused by deficiency is dry, squamous and dry skin.Along with the deterioration of living environment, human body suffers the invasion and attack of more and more harmful substances, causes resistance of human body to descend, and various anaphylaxiss also emerge in an endless stream.To begin conditioning from endogenous cause of ill at first exactly.The traditional Chinese medical science has incomparable advantage in this respect.Doctor trained in Western medicine is thought primary disease cause of disease complexity, is commonly considered as the allergy associated diseases, can be caused by factors such as haptoreaction, disease factor, delayed ischemic neurological deficits and endocrine.

Chinese traditional treatment divides damp-heat type, blood-deficiency and wind-dry type and stagnation of dampness due to deficiency of the spleen type dermatosis clinically.Whole body therapeutic is often ignored in Chinese traditional treatment in the past, and only payes attention to topical therapeutic, and based on the treatment of Chinese medicine external fumigation and washing, this method facts have proved poor effect merely, and symptom is alleviated only but is easy to recurrence.The patient shows effect mostly repeatedly, and touching difficulty more influences quality of life.Though most patients seek medical advice in many ways, generally poor effect all causes anxiety, depression, and then further increases the weight of the state of an illness, has a strong impact on work and quality of life.Treat these disease doctors trained in Western medicine clinically and adopt medicines such as antiallergic, calmness, hormone more,, daktarin flat, PIKANGWANG, the peaceful tincture of dermatosis etc. as dermatosis.They mostly are the preparation of Western medicine chemical analysis greatly, and for the patient that sick time is short, symptom is lighter, these medicines still have certain effect.But, the state of an illness heavier patient long for the course of disease, only there is temporary transient itching-relieving action in these medicines, the basic possibility of not having healing.Also some patient can produce certain drug resistance after long-time medication repeatedly, at this moment even itching-relieving action can not have yet.

Adopt clinically and variously know Chinese medicine and western medicine or its mixture all fails to tackle the problem at its root, particularly life-time service some drugs such as steroid can have side effects to skin and even whole body, and the result cures the symptoms, not the disease, and loses more than gain.Also be no lack of still clinically and cure various dermatosiss, but effect is also desirable not to the utmost with some Chinese medicine.The present invention just institute is all undesirable at the curative effect of present medicine for the treatment of antibacterial or dermatomycosis, and it is slower to take effect, big to the human body side effect, and easily outbreak repeatedly, the shortcoming that touching difficulty heals, a kind of instant effect of invention production, the medicine that side effect is little, biocidal property is strong are to remove patient's misery.

Summary of the invention

Technical problem to be solved by this invention is, a kind of Chinese medicine composition for the treatment of antibacterial or dermatomycosis and preparation method thereof is provided, curative effect at treatment antibacterial or dermatomycosis medicine in existing market and the clinical practice is undesirable, it is slower to take effect, and easily repeatedly, be easy to generate drug-fast shortcoming, on the basis of traditional medicine,, adopt modern processing method to develop meticulously in conjunction with clinical experience for many years.The present invention is to each effective ingredient science compatibility of component medicine, is a kind of instant effect, side effect is little, biocidal property is strong medicine, can effectively remove patient's misery.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of antibacterial or dermatomycosis, form by endo-medicine and external used medicine,

In the described endo-medicine, the ratio of weight and number of various components is: 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Caulis Spatholobis, 10～20 parts of Flos Campsiss, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the Radixs Astragali, 10～20 parts of Cortex Moutans, 10～20 parts in Semen Persicae, 10～20 parts of Flos Loniceraes, 10～20 parts of Herba Violae;

The ratio of weight and number of various components is in the described external used medicine: 10～30 parts of Fructus Cnidiis, 10～30 parts of Indigo Naturaliss, 10～30 parts of Hedyotidis Diffusaes, 10～30 parts of the Fructus Kochiae, 10～30 parts of Cortex Dictamnis, 5～10 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 10～30 parts of the Radixs Stemonae, 10～30 parts of Herba Portulacaes, 10～30 parts of Radix Sophorae Flavescentiss, 10～30 parts of Radix Arnebiae (Radix Lithospermi)s, 10～30 parts of dried Alumens, 10～30 parts of Herba Houttuyniae, 10～30 parts on Cortex cinnamomi japonici (Ramulus Cinnamomi).

The Chinese medicine composition of described treatment antibacterial or dermatomycosis, the ratio of weight and number of various components can be preferably in the endo-medicine: 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Caulis Spatholobis, 10～15 parts of Flos Campsiss, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of the Radixs Astragali, 10～15 parts of Cortex Moutans, 10～15 parts in Semen Persicae, 10～15 parts of Flos Loniceraes, 10～15 parts of Herba Violae;

The ratio of weight and number of various components can be preferably in the described external used medicine: 10～20 parts of Fructus Cnidiis, 10～20 parts of Indigo Naturaliss, 10～20 parts of Hedyotidis Diffusaes, 10～20 parts of the Fructus Kochiae, 10～20 parts of Cortex Dictamnis, 5～10 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 10～20 parts of the Radixs Stemonae, 10～20 parts of Herba Portulacaes, 10～20 parts of Radix Sophorae Flavescentiss, 10～20 parts of Radix Arnebiae (Radix Lithospermi)s, 10～20 parts of dried Alumens, 10～20 parts of Herba Houttuyniae, 10～20 parts on Cortex cinnamomi japonici (Ramulus Cinnamomi).

The Chinese medicine composition of described treatment antibacterial or dermatomycosis, the ratio of weight and number of various components also can be preferably in the endo-medicine: 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Caulis Spatholobis, 10～20 parts of Flos Campsiss, 10～20 parts of Radix Angelicae Sinensis, 10～15 parts of the Radixs Astragali, 10～15 parts of Cortex Moutans, 10～15 parts in Semen Persicae, 10～15 parts of Flos Loniceraes, 10～15 parts of Herba Violae;

The ratio of weight and number of various components yet can be preferably in the described external used medicine: 10～25 parts of Fructus Cnidiis, 10～25 parts of Indigo Naturaliss, 10～25 parts of Hedyotidis Diffusaes, 10～25 parts of the Fructus Kochiae, 10～25 parts of Cortex Dictamnis, 5～10 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 10～25 parts of the Radixs Stemonae, 10～25 parts of Herba Portulacaes, 10～25 parts of Radix Sophorae Flavescentiss, 10～25 parts of Radix Arnebiae (Radix Lithospermi)s, 10～25 parts of dried Alumens, 10～25 parts of Herba Houttuyniae, 10～25 parts on Cortex cinnamomi japonici (Ramulus Cinnamomi).

The Chinese medicine composition of described treatment antibacterial or dermatomycosis, the ratio of weight and number of various components also can be preferably in the endo-medicine: 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Caulis Spatholobis, 10～15 parts of Flos Campsiss, 10～15 parts of Radix Angelicae Sinensis, 10～20 parts of the Radixs Astragali, 10～20 parts of Cortex Moutans, 10～20 parts in Semen Persicae, 10～20 parts of Flos Loniceraes, 10～20 parts of Herba Violae;

The ratio of weight and number of various components also can be preferably in the described external used medicine: 15～30 parts of Fructus Cnidiis, 15～30 parts of Indigo Naturaliss, 15～30 parts of Hedyotidis Diffusaes, 15～30 parts of the Fructus Kochiae, 15～30 parts of Cortex Dictamnis, 5～10 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 15～30 parts of the Radixs Stemonae, 15～30 parts of Herba Portulacaes, 15～30 parts of Radix Sophorae Flavescentiss, 15～30 parts of Radix Arnebiae (Radix Lithospermi)s, 15～30 parts of dried Alumens, 15～30 parts of Herba Houttuyniae, 15～30 parts on Cortex cinnamomi japonici (Ramulus Cinnamomi).

The Chinese medicine composition of described treatment antibacterial or dermatomycosis, endo-medicine is fried in shallow oil decoction in use and is taken, but 1 dose of every day, decocting is obeyed at twice, and per 7 days is a course of treatment.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of antibacterial or dermatomycosis, the endo-medicine dosage form is that the preparation method of capsule comprises: described component is added 10 times of amounts of weight ethanol, heating and refluxing extraction 3 times each 2 hours, merges 3 extracting solution, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, behind the sucking filtration, when the relative density of filtrate is 20 ℃ 1.08; Described filtrate flow is the macroporous adsorptive resins of 10L through volume, use the deionized water or the distilled water eluting of 10 times of resin column volumes afterwards, 95% ethanol elution of 5 times of resin column volumes of reuse, collect ethanol elution, remove alcohol solvent, obtain component medicated powder, incapsulate and be made as capsule, every capsules dress 0.4g.

For solving the problems of the technologies described above, the present invention provides a kind of preparation method for the treatment of antibacterial or dermatomycosis Chinese medicine composition again, and external used medicine is that the preparation method of unguentum may further comprise the steps:

According to described portion rate with Fructus Cnidii and the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) with 95% soak with ethanol three times, each soak time was respectively 2 hours, 1.5 hours, 1 hour; Each 80～85 ℃ of heat in back of soaking are extracted, and alleviate toxicity; Used ethanol is respectively with the gross weight ratio of Fructus Cnidii, two kinds of medical materials of the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae): for the first time 10 times of amounts, the second time 8 times of amounts, 6 times of amounts for the third time; Merge three times ethanol extract, be concentrated into relative density and be 1.08 concentrated solution, stand for standby use; All the other described components are mixed by proportioning except that dried Alumen, drop into pulverizer and be ground into fine powder, after sieving, puts into fine powder the acid and alkali-resistance infusion kettle, at normal temperatures and pressures, flooded 10～20 days with ethanol is common, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation, and are mixed with aforementioned concentrated solution then; Described mixed liquid heating is concentrated into pasty state, puts into 80 ℃ of oven dry of baking oven postcooling, grind to form fine-powdered, mix vaseline and make unguentum with dried Alumen is mixed.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of antibacterial or dermatomycosis Chinese medicine composition, and when external used medicine was gel, the step of preparation comprised:

Described medicine shredded except that dried Alumen join in the multi-function extractor, add ratio of weight and number and be 3000 parts water logging bubble 30～40 minutes, decocts after 1.5 hours, it is standby to take out first time decoction liquor; Medicinal residues adding ratio of weight and number is after 3000 parts decocting boils 1 hour, take out decoction liquor for the second time, twice decoction liquor merged filtration, it is 1000 parts solution that filtrate decompression is concentrated into ratio of weight and number, staticly settled 24～36 hours, and drew supernatant, be heated to that to add ratio of weight and number after 40～50 ℃ be 2 parts the ethyl hydroxybenzoate and the dried Alumen of porphyrize, stir, under normal pressure, be condensed into ratio of weight and number and be 500 parts concentrated solution; Carbomer-940 and the ratio of weight and number that with ratio of weight and number is 15 parts is that the distilled water that 3 parts Tween-80 and ratio of weight and number are 200 parts mixes, be that to be dissolved in ratio of weight and number be in 300 parts the distilled water for 15 parts triethanolamine then with ratio of weight and number, add aforementioned mixed liquor, 45 parts the propylene glycol that adds ratio of weight and number after stirring, be that 500 parts concentrated solution mixes at last with described ratio of weight and number, stir, gel, directly smear the affected part and get final product.

Gel easily is coated with exhibition, easily eccysis, and no greasy feeling, energy absorptive tissue transudate does not hinder the skin normal function, pollution clothes not, denseness is little and help the release of medicine.Shortcoming is that lubrication is relatively poor, and easily dehydration and going mouldy often needs interpolation wetting agent and antiseptic.

For solving the problems of the technologies described above, the present invention provides a kind of preparation method for the treatment of antibacterial or dermatomycosis Chinese medicine composition again, and when the external used medicine dosage form was spray, the step of preparation comprised:

According to described portion rate with Fructus Cnidii and the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) with 65% alcohol reflux secondary, add the ethanol of 5 times of amounts for the first time, refluxed 2 hours, the ethanol that add 4 times of amounts the second time refluxed 2 hours, reclaimed ethanol then, filtered to get filtrate 1, and is standby; All the other components are boiled secondary except that dried Alumen adds decocting, add the water of 8 times of amounts for the first time, decocted 1.5 hours, add the water of 6 times of amounts for the second time, decocted 1.5 hours, filter to get filtrate 2, standby; Above-mentioned filtrate 1, filtrate 2 are merged, dried Alumen is ground in the input amalgamation liquid of back stir; Described amalgamation liquid is evaporated to relative density 1.10～1.15 (60 ℃) concentrated solution; The ethanol mixture that filters, leaves standstill after 24 hours with 10 times of amounts soaked 10 days, got final product in the medical spray gun of packing into, can directly spray the affected part during use.

A kind of using method for the treatment of the external preparation of antibacterial or dermatomycosis is embrocated the external preparation of preparation, the spraying affected part, and every day can 3-5 time, and embrocating 7 days continuously is a course of treatment.

Advantages such as compared with prior art teach, present technique has convenient drug administration, and medicament is easy to make, and is with low cost.The present invention adopts the Chinese crude drug of the different property of medicine, has carried out the science compatibility, can reach ideal therapeutic effect, and safety, and toxic and side effects is little, and is easy to use, and healing time is short, cures the back and is difficult for recurrence.Can create good social is worth and economic interests.

The specific embodiment

The present invention inherits the medical heritage of motherland, utilizing the resources advantage of Chinese herbal medicine, is a kind of Chinese medicine composition of safe, convenient, inexpensive, pure natural, in order to treat various antibacterials or dermatomycosis and other dermatosiss, it is big to remedy the Western medicine toxic and side effects, to defectives such as person harm are big.Preparation technology of the present invention is simple, and medicine components is cheap, and good effect can reach good social effect and economic interests.

The traditional Chinese medical science thinks, various dermopathic endogenous causes of ill insufficiency of the spleenly are stranded transformation failure of spleen by damp and hot; Exopathogenic factor is the damp and hot heresy of impression, fills in space between skin and muscles.Prolonged illness is deficient vital QI leading to lingering of pathogen then, stagnation of dampness due to deficiency of the spleen, or wind syndrome due to blood-deficiency is living dry, wind-dryness pent-up, skin cervical carcinoma with cachexia." element ask the five internal organs generate a piece of writing " said: " lung close fur, its flourish mao is also." so during insufficiency of lung-QI then skin lose nourish and cause dry matt, hair is withered, eczema dermatosis very then.The Sui Dynasty Chao Yuanfang (550-630 A.D.) is put down in writing in " General Treatise on the Cause and Symptoms of Diseases ": " all skin ulcer persons of a specified duration, interior-heat is outer empty, by rheumatism is taken advantage of, then the women's head-ornaments health is all given birth to skin ulcer ".Record in " Ling Shu Miraculous Pivot or Divine Axis determine gas ": " part of the body cavity above the diaphragm housing the heart and lungs exploitation, a surname grain rice flavor, fill body, pool hair at smoked skin, if irrigating of revealing of mist is meaning gas.”。Analyze according to traditional Chinese medical science the four methods of diagnosis and eight key links, the dermatosis cause of disease can reduce wind, wet, hot, poison four big classes, and these four kinds of causes of disease all are related mutually, for example the traditional Chinese medical science is thought, more ailment said due to cold or exposure is whenever held heat under the arm, is held under the arm wet and the generation dermatosis, and " heat " " poison " of the traditional Chinese medical science means the cause of disease that causes psoriasis, tinea manus and pedis, eczema, all kinds of dermatosis and skin pruritus, comedo, acne.Though the dermatosis performance is various, its main diseases dehumidifies so control with dispelling wind because of nothing more than above four kinds, and heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling are main rule.

Antibacterial or dermatomycosis are the card of " deficiency in origin and excess in superficiality " as can be seen from above-mentioned argumentation, and " deficiency in origin " is meant asthenia of pulmonosplenic qi, " mark is real " be meant wind, wet, heat three is evil in suffering from, and adopts the method for " inside and outside rule together " in view of the above.Oral medicine is made laws with " treating both the principal and secondary aspects of a disease ", the Radix Astragali, Radix Salviae Miltiorrhizae in the side, Semen Persicae invigorating vital QI consolidating superficial resistance, promoting pus discharge and tissue regeneration strengthening diuretic; Caulis Spatholobi, the Flos Campsis activating blood circulation to dissipate blood stasis; The Radix Angelicae Sinensis Fructus Alpiniae Oxyphyllae of calming the nerves; Cortex Moutan, Flos Lonicerae, Herba Violae detoxicating detumescence and apocenosis.All medicines share the benefiting QI for strengthening the superficies granulation promoting with solid its " basis ", and the damp eliminating parasite killing that dispels the wind, detumescence and apocenosis are to control its " mark ".

The Semen Persicae hardship, sweet, put down the special medicine that closes for blood stasis blood.Bitter to let out stagnant blood, sweet with tissue regeneration promoting blood." medicine justice ": Semen Persicae, bitter in the mouth can rush down heat in blood, and the body profit can be grown dryness of the intestine.If gross weight grinds many usefulness, walk Liver Channel, main broken blood-retention, water, and pain all over month by month, extremity wood numbness, left side hemiplegia, left sufficient patient is relaxed through the promoting the circulation of blood of invigorating blood circulation with it, the merit that eliminating blood stasis to promote regeneration of blood is arranged if few usefulness is mashed in peeling, is gone into large intestine, controlling blood depletion just closes, the dry dyschezia of blood with its make moist removing heat from blood and blood, has relieving accumulation of pathogens to lead to stagnant power.

The Radix Salviae Miltiorrhizae hardship is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.Be used for the costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, the tumbling down pain of injury, menoxenia, the amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.The lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and the stillborn fetus that falls ends the metrorrhagia dysentery, the regulating menstruation arteries and veins.

A kind of Chinese medicine material of Flos Campsis has promoting the circulation of blood blood stasis removing, cooling blood, expelling wind dampness removing, heat-clearing and toxic substances removing, and acrid in the mouth acid, cold nature is returned liver, pericardium channel, function promoting blood circulation to remove blood stasis, cooling blood, expelling wind.Cure mainly menoxenia, amenorrhea lump in the abdomen, puerperal swelling of the breast, skin pruritus. " Amplification on Materia Medica addendum ": Flos Campsis, the key medicine of controlling pain in the blood also, and the nourishing YIN victory is very, is stamped to keep and walk alone." Nanning City's medicine will ": the merit of eliminating inflammation and expelling toxin, hemostasis and pain-relieving, evacuation of pus granulation promoting is arranged, control red Hakuri.

The Herba Violae heat-clearing and toxic substances removing, clearing away heat-damp and promoting diuresis cures mainly furuncle, carbuncle, scrofula, jaundice, dysentery, diarrhoea, conjunctival congestion, sore throat, venom.Bitter in the mouth cold in nature is gone into the heart, Liver Channel.Join Flos Lonicerae, the detoxifcation removing heat from blood, the merit of detumescence heat radiation strengthens.Be the good medicine of heat-clearing and toxic substances removing.

Caulis Spatholobi property hardship, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, collateral dredging.Be used for menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carry it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Flos Campsis, Caulis Spatholobi is for oral administration to be that the treatment blood stasis is not loose the good medicine that nourishing blood silt is invigorated blood circulation.

Its sweet in the mouth of Radix Angelicae Sinensis and weighing, so specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, the gas medicine in the sincere blood, the also panacea in the blood.About mending of assistant to mend then, thus can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the relieving constipation bitterly of dispelling, relieving rigidity of muscles and joints is controlled contracture, paralysis, card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can loose greatly, and show not hold back the person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, so desire its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

The Radix Astragali is based on tonify deficiency, can invigorating QI to consolidate the body surface resistance, and diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Be used for that insufficiency of vital energy and blood, skin infection cave in, difficulty in discharging of pus or burst for a long time and do not hold back the person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows that the Radix Astragali includes and multiple antibiotic effective ingredient, and the energy enhancing body's immunological function, therefore can also be used to prevent the generation of some infectious disease." book on Chinese herbal medicine meets former " carries: " Radix Astragali can all void of tonifying five ZANG-organs, controls the stringy pulse spontaneous perspiration, rushes down YIN-fire, removes lung-heat, losslessly then sends out, and has antiperspirant then to end." be the good medicine of promoting resistance and defence disease.

The Cortex Moutan bitter in the mouth is slightly cold, can clearing heat in YING system branch, blood system excess-heat, the merit of cooling blood for hemostasis is arranged.Control epidemic febrile disease heat and go into nutrient blood, the absurd row of forcing blood.Return Liver Channel.Function cures mainly clearing away heat and cooling blood, eliminating stasis to stop pain.Be used for maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.The effect of Cortex Moutan clearing away heat and cooling blood is preferable, and the branch excess-heat that can purify the blood can be controlled fever due to yin deficiency again." herbal classic " carries it: " main cold and heat, the apoplexy contract is removed hard disease blood stasis and is stayed the house the intestines and stomach from, convulsion, infantile convulsion pathogen, and settling five organs is treated the carbuncle skin ulcer.”

The Flos Lonicerae heat clearing away is loose malicious, and Compendium of Material Medica is carried " Flos Lonicerae is good at removing toxic substances, so control carbuncle, toxic swelling, skin ulcer tinea ... ".Since ancient times, Flos Lonicerae is usually used in heat-clearing and toxic substances removing, the heating of treatment epidemic febrile disease, toxic-heat and blood stasis, diseases such as carbuncle and ulcer.Modern pharmacological research shows, that Flos Lonicerae has is antibacterial, antiviral, antiinflammatory, analgesic, regulate the effect traditional Chinese medical science such as immunity and think, Flos Lonicerae is cold in nature, sweet in the mouth, gas are put down, and has the effect of heat-clearing and toxic substances removing, can treat diseases such as pyretic toxicity abscess, carbuncle furuncle.And have the diffusing effect of a surname concurrently.The Flos Lonicerae antipyretic and antidote functions is quite strong.

The traditional Chinese medical science thinks that the cause of disease of antibacterial or dermatomycosis mainly is that the heresy of rheumatism pyretic toxicity is strongly fragrant in skin, the damp and hot knot of fighting, contamination skin and falling ill.Hedyotidis Diffusae rushes down the damp and hot of three warmers clearly; Cortex Dictamni, Radix Sophorae Flavescentis, the clear pain-relieving powder for treating thermal detoxification of Herba Portulacae; Dried Alumen, Cortex Moutan astringent therapy are held back skin ulcer; The Fructus Kochiae, Indigo Naturalis, the antiinflammatory of Fructus Cnidii Anti-Puritic and insecticidal, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) removing obstruction for relieving pain parasite killing; The Radix Stemonae sterilization poison of dispelling is treated the skin ulcer tinea; Cortex cinnamomi japonici (Ramulus Cinnamomi), Herba Houttuyniae, degerming antiinflammatory.Clearing heat and expelling damp, detoxifcation invigorate blood circulation speckle removing, the antipruritic merit of convergence are received in all medicine combinations of inner and outside altogether.Sick blood-deficiency and wind-dry for a long time, failure of skin and muscle to be nourished so plumpness is chapped, is not touchingly healed.Control and answer blood enriching and dryness moistening, removing damp to relieve itching.Inside and outside with executing, specimen is controlled altogether.Should introduce the state of an illness to patient simultaneously, make patient eliminate fear disease; Polytrophic light food should be eaten in the diet aspect, polyphagia vegetable, fruit, pungent irritable foods such as diet is greasy, fish raw meat, chicken and duck Carnis caprae seu ovis; Do not want the contact allergy source; The inhabitation aspect, the peace and quiet that should keep clean, bright and clear, humiture is suitable, and good daily life custom is formed in often ventilation, and acute stage, avoid with hot water and the washcoated affected part of irritating article.

Fructus Cnidii suffering, hardship, temperature; Slightly poisonous.Return kidney channel.Cure mainly warming the kidney to invigorate YANG, dampness is dispeled the wind, parasite killing.Be used for sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; " Bencao Jingshu " carries: Fructus Cnidii, and bitter in the mouth is flat; " not Lu " be hot sweet nontoxic; Modern detailed its abnormal smells from the patient, when the warm-dryness syndrome of must holding concurrently, sun also.So swell and ache in housewife people's the moon, man's impotence pruritus due to damp pathogen removes stagnated QI, sharp joint, malignant boil." not Lu " warming the middle warmer and descending qi makes married woman's Zifu heat, and the man is cloudy strong, has made us son.Lid can dehumidify with tongue, temperature energy cold expelling, and suffering can be moistened kidney, and sweet energy strengthening the spleen is so can remove the wet disease of viscera connecting with this channel of all deficiency and coldness of married woman man.Cold-damp was both removed, and then disease is gone, performance Yiyang, thus disease, and have tonification also.

The Fructus Kochiae is cold in nature, acrid in the mouth, hardship.The energy clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.Be used for difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, antibacterial or diseases such as dermatomycosis, skin pruritus." key medicine is divided agent " carries: " go into kidney, bladder two warps.Diuresis, clearing away damp-heat.Control dysuria, gonorrhea, leukorrhagia, hernia, rubella, sore, scabies, pudendum pruritus due to damp pathogen.Be the surgery good medicine of treatment antibacterial or dermatomycosis!

Radix Arnebiae (Radix Lithospermi) is cold in nature, sweet in the mouth, one-tenth.GUIXIN, Liver Channel.Cure mainly removing heat from blood, invigorate blood circulation, the detoxifcation rash.Be used for that heat in blood poison is contained, purple black, the measles without adequate eruption of macule, skin infection, antibacterial or dermatomycosis, burn due to hot liquid or fire.Clearing away heat and cooling blood is used for measles, the calentura skin eruption, and antibacterial or dermatomycosis, hematuria, stranguria with blood, dysentery, skin infection is separated erysipelas." book on Chinese herbal medicine justice " carries: Radix Arnebiae (Radix Lithospermi), and the abnormal smells from the patient bitter cold, and the color purple is gone into blood, so the heat of cleaning blood system.Ancient to control the accumulation of heat of internal organs, the then special treatment of smallpox infections of descendant is treated skin eruption, all positive purport of heat clearing and blood cooling and hold concurrently.

Herba Hedyotidis Diffusae is Herba Hedyotidis Diffusae, two leaves, Herba Commelinae Bengalensis, Chinese Lobelia again.Mildly bitter flavor, sweet, cold.Go into stomach, large intestine, small intestine meridian, the clearing up internal heat by using drugs of bitter in taste and cold in nature detoxifcation, sweet cold eliminating damp-heat has stronger removing toxicity for eliminating carbuncles effect to carbuncle, pharyngalgia, snakebite etc.Generally be used for the treatment of sore, laryngopharynx swelling and pain, abdominalgia with intestinal abscess, venom, also be used for the puckery pain of pyretic stranguria, dysuria.Be the good medicine of damp eliminating of drawing out pus by applying a plaster to the affected part.

The Radix Sophorae Flavescentis hardship, cold.GUIXIN, liver, stomach, large intestine, urinary bladder channel heat clearing and damp drying, parasite killing, diuresis.Be used for hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, antibacterial or dermatomycosis, eczema, skin pruritus, scabies leprosy; Often being used in combination with Hedyotidis Diffusae, is the external good medicine of treatment antibacterial or dermatomycosis.

Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) suffering, hardship, flat.Poisonous.Cure mainly eliminating stagnation, relieve oedema or abdominal distension through diuresis or purgation, pain relieving, parasite killing.Be used for aqueous vapor swelling, tuberculous lymphadenitis; Scabies, tinea are controlled in external, kill fly, maggot.The panacea that a small amount of external is treatment antibacterial or dermatomycosis though the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) has certain toxicity." herbal classic " carries it: main cough with dyspnea, removing mass is poly-, diet, cold and heat, aqueous vapor, malignant boil.Especially chronic bacterial or dermatomycosis there is specially good effect.

The expectorant of dried Alumen energy, dampness, antidiarrheal, hemostasis, detoxifcation, parasite killing.Control epilepsy, sore throat, remorse saliva is stopped up very, hepatitis, jaundice, general edema with yellowish skin, stomach, duodenal ulcer, uterine prolapse, leucorrhea, dysentery, epistaxis, aphtha of the mouth and tongue, skin ulcer hemorrhoid scabies." detailed outline " carries: " tell down sputum drink phosphorus, the dampness detoxifcation chases after saliva, the hemostasis analgesic therapy, meat is disliked in erosion, gives birth to good meat, and it is swollen to control the carbuncle furuncle, malignant boil, epilepsy, subcutaneous ulcer disease, relieving bowels, all diseases of ability to speak eyes, brave dog snakes and scorpions hundred insect bites.″

Indigo Naturalis is hot in nature, warming middle-JIAO, and pain relieving is regulated the flow of vital energy, dampness, the contrary acid regurgitation of stopping vomiting, headache due to JUE YIN disorder, the coldness of ZANG-organ is vomited and diarrhoea, abdominal distention, abdominal pain during menstruation is had loose bowels just before dawn, vascular hypertension, beriberi, hernia, aphthous ulcer, toothache, antibacterial or dermatomycosis.Acrid in the mouth, hardship, dispersing cold for relieving pain is gone into liver, spleen, stomach, large intestine, kidney channel.External has apparent in view pain relieving and therapeutic effect." Thunder God is concocted the property of medicine and separated ": warming middle-JIAO, pain relieving is regulated the flow of vital energy, dampness." herbal classic " carries: main warming the middle warmer and descending qi, and pain relieving, the cough with dyspnea cold and heat, the dehumidifying arthralgia due to stagnation of blood by ailment said due to cold or exposure, loosing the interspaces of skin and muscles, is the good medicine of treatment antibacterial or dermatomycosis external.

The Herba Houttuyniae suffering is slightly cold.Return lung meridian, be used as medicine, the traditional Chinese medical science is thought its acrid in the mouth, cold, skin ulcer, promoting urination to remove dampness, invigorating the stomach and promoting digestion are treated in energy heat-clearing and toxic substances removing, the detumescence of row's pain, with controlling excess-heat, pyretic toxicity, damp, disease heat is the lung abscess suffered from, sore swollen toxin, hemorrhoidal hemorrhage, retention of heat in the spleen and stomach etc., list is used or the compatibility compound recipe, the equal determined curative effect of the use of oral administration and externally or multiple Dietotherapy method among the people.Pharmacological research, the Herba Houttuyniae master contains volatile oil, and multiple components such as decanoylacetaldehyde houttuynine sodium bisulfite have the inhibition antibacterial action to various Xenorhabduses, coccus, influenza virus, leptospira etc., and can improve the human immunity regulatory function.

The Radix Stemonae is sweet, bitter, tepor.Return lung meridian.Its function cures mainly nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.Be used for new chronic cough and cough, pulmonary tuberculosis cough, pertussis; Be used for head louse outward, body louse, enterobiasis, pudendal pruritus.The Radix Stemonae has antibacterial action clearly.Radix Stemonae decoct reaches the immersion of Radix Stemonae ethanol various pathogens such as streptococcus pneumoniae, beta hemolysis type streptococcus, meningococcus, staphylococcus aureus, Staphylococcus albus and dysentery bacterium during in vitro tests, Bacillus typhi, Salmonella paratyphi, escherichia coli, Bacillus proteus, diphtheria corynebacterium, pneumobacillus, bacillus pestis, anthrax bacillus, bacillus subtilis, and vibrio cholera, Bacillus tuberculosis etc. all have bacteriostasis in various degree.Radix Stemonae infusion has certain inhibitory action external to some pathomycete.

Cortex Dictamni is cold in nature, bitter in the mouth.Cure mainly heat clearing and damp drying, the detoxifcation of dispeling the wind.Be used for that damp and hot sore, yellow fluid are dripping, antibacterial or dermatomycosis, scabies skin ulcer leprosy, rheumatism pyretic arthralgia, jaundice dark coloured urine.The normal medicines such as Radix Sophorae Flavescentis, the Fructus Kochiae that cooperate are with using." book on Chinese herbal medicine is original " carries it: " control all mange, aversion to wind, scabies, Fructus Myricae rubrae, all skin ulcer pyretic toxicity.″

Herba Portulacae acid, cold.Return liver, large intestine channel.Be applicable to dysentery, heat-clearing and toxic substances removing, cooling blood for hemostasis.Be used for toxic-heat and blood stasis, the carbuncle furuncle, antibacterial or dermatomycosis, erysipelas, snake bite and insect sting is had blood in stool, hemorrhoidal bleeding, metrostaxis." open value greatly surely new book on Chinese herbal medicine ": " Herba Portulacae, clothes not white all the year round." " Bencao Jingshu ": " and not white all the year round, always say its removing heat from blood benefit blood, disease is removed the light merit ear of body.”

Cortex Moutan, its bitter in the mouth and little suffering, its gas is cold and nontoxic, and hot poly-with eliminating stagnation, bitter cold is removed heat in blood, goes into blood system, and the key medicine of removing heat from blood heat is also.The cold and heat person, the time of deficiency of YIN heat in blood also.Apoplexy clonic convulsion, convulsion, infantile convulsion, interior-heat caused by deficiency of YIN all, nutrient QI and blood being insufficient so.Heat is gone then blood cold, and then fresh blood is given birth to, cloudy gas is multiple in cold, and then fire is scorching and do not have card because of hot air wind producing again for cloudy gas, so know the master's.Carbuncle skin ulcer person, heat is stopped up blood stasis and is formed also.The removing heat from blood promoting the circulation of blood is so treat the carbuncle skin ulcer.The hot blood that can loose, hardship can be purged heat, thus can remove the blood system pathogen, and the hard blood stasis of disease stays the house the intestines and stomach.

Cortex cinnamomi japonici (Ramulus Cinnamomi) suffering, temperature, nontoxic.Liver and kidney tonifying, qualcomm meridian, dispersing wind and cold removes arthralgia chiefly caused by damp pathogen, warm waist knee joint, preventing or arresting vomiting is told, and is the yang aspect of yang medicine, and property is floating, has the fire of benefit supporing yang, the temperature compensation QI and blood, the effect of conducting fire back to its origin has the effect of expansion blood capillary, and dermatophytes is had stronger inhibitory action.

This Chinese medicine composition internal and external application, nourishing blood relieves internal heat, treating both the principal and secondary aspects of a disease, both mutually promote oral and external applied medicine, improve immunity of human body itself, and activating blood circulation to dissipate blood stasis does not produce any side effect to human body, and is safe and effective, can reach the purpose of the strong body that gets rid of illness.

The present invention treats the Chinese medicine composition of antibacterial or dermatomycosis, and the dosage form of endo-medicine is a capsule, and its preparation method may further comprise the steps:

With Radix Salviae Miltiorrhizae 2000g, Caulis Spatholobi 2000g, Flos Campsis 2000g, Radix Angelicae Sinensis 2000g, Radix Astragali 2000g, Cortex Moutan 2000g, Semen Persicae 2000g, Flos Lonicerae 2000g, Herba Violae 2000g add 10 times of amounts of weight ethanol, heating and refluxing extraction 3 times each 2 hours, merges 3 extracting solution, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, behind the sucking filtration, when the relative density of filtrate is 20 ℃ 1.08; Described filtrate flow is the macroporous adsorptive resins of 10L through volume, use the deionized water or the distilled water eluting of 10 times of resin column volumes afterwards, 95% ethanol elution of 5 times of resin column volumes of reuse, collect ethanol elution, remove alcohol solvent, obtain component medicated powder, incapsulate and be made as capsule, every capsules dress 0.4g.Can be once two during use, every day three times.

The preparation method of external used medicine unguentum is:

According to described portion rate with Fructus Cnidii 3000g and Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 500g with 95% soak with ethanol three times, each soak time was respectively 2 hours, 1.5 hours, 1 hour; The back 85 ℃ of heat of each immersion are extracted, and alleviate toxicity; Used ethanol is respectively with the gross weight ratio of Fructus Cnidii, two kinds of medical materials of the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae): for the first time 10 times of amounts, the second time 8 times of amounts, 6 times of amounts for the third time; Merge three times ethanol extract, be concentrated into relative density and be 1.08 concentrated solution, stand for standby use; With Indigo Naturalis 3000g, Hedyotidis Diffusae 3000g, Fructus Kochiae 3000g, Cortex Dictamni 3000g, Radix Stemonae 3000g, Herba Portulacae 3000g, Radix Sophorae Flavescentis 3000g, Radix Arnebiae (Radix Lithospermi) 3000g, Herba Houttuyniae 3000g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 3000g mixes by proportioning, drops into pulverizer and is ground into fine powder, puts into the acid and alkali-resistance infusion kettle after fine powder sieves, at normal temperatures and pressures, flooded 20 days with ethanol is common, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation, mixed with aforementioned concentrated solution then; Described mixed liquid heating is concentrated into pasty state, puts into 80 ℃ of oven dry of baking oven postcooling, grind to form fine-powdered, mix vaseline and make unguentum with dried Alumen 3000g is mixed.

The preparation method of the Chinese medicine composition of treatment antibacterial of the present invention or dermatomycosis, when external used medicine was gel, the step of its preparation comprised:

The used mixed agent of gel is: carbomer-94015g, propylene glycol 45g, Tween-80 3g, ethyl hydroxybenzoate 2g, triethanolamine 15g;

With described medicine Fructus Cnidii 300g, Indigo Naturalis 300g, Hedyotidis Diffusae 300g, Fructus Kochiae 300g, Cortex Dictamni 300g, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 50g, Radix Stemonae 300g, Herba Portulacae 300g, Radix Sophorae Flavescentis 300g, Radix Arnebiae (Radix Lithospermi) 300g, dried Alumen 300g, Herba Houttuyniae 300g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 300g.Except that dried Alumen, shred and join in the multi-function extractor, add water 3000mL and soak 30min, decoct 1.5h, get decoction liquor, add water 3000mL again and decoct 1h, merge decoction liquor, filter, filtrate decompression is concentrated into 1000mL, and the adding clarifier is an amount of, staticly settle 24h, draw supernatant, be heated to the dried Alumen 300g that adds ethyl hydroxybenzoate and porphyrize after 40～50 ℃, stir, normal pressure is concentrated into 500mL, promptly gets the 500mL concentrated solution; Carbomer is mixed with Tween-80 and 200mL distilled water, and triethanolamine adds above-mentioned mixed liquor after being dissolved in the 300mL distilled water, stirs evenly to add propylene glycol again, with 500mL concentrated solution mixing and stirring, promptly gets gel again.Can directly be applied in the affected part during use, one day three times.

Gel easily is coated with exhibition, easily eccysis, and no greasy feeling, energy absorptive tissue transudate does not hinder the skin normal function, and denseness is little and help the release of medicine, not pollution clothes; Shortcoming is that lubrication is relatively poor, and easily dehydration and going mouldy often needs interpolation wetting agent and antiseptic.

The preparation method of treatment antibacterial or dermatomycosis Chinese medicine composition, the external used medicine dosage form is a spray, the step of preparation comprises:

According to described portion rate with Fructus Cnidii 3000g and Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 500g with 65% alcohol reflux secondary, the ethanol that adds for the first time 5 times of amounts of Fructus Cnidii and Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) weight sum, refluxed 2 hours, the ethanol that adds for the second time 4 times of amounts of Fructus Cnidii and Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) weight sum, refluxed 2 hours, reclaim ethanol then, filter to get filtrate 1, standby; With all the other component Indigo Naturalis 3000g, Hedyotidis Diffusae 3000g, Fructus Kochiae 3000g, Cortex Dictamni 3000g, Radix Stemonae 3000g, Herba Portulacae 3000g, Radix Sophorae Flavescentis 3000g, Radix Arnebiae (Radix Lithospermi) 3000g, Herba Houttuyniae 3000g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 3000g decocts with water secondary, adds the water of 8 times of amounts of above-mentioned component weight sum for the first time, decocts 1.5 hours, the water that adds for the second time 6 times of amounts of above-mentioned component weight sum, decocted 1.5 hours, and filtered to get filtrate 2, standby; Above-mentioned filtrate 1, filtrate 2 are merged, dried Alumen 3000g is ground in the input amalgamation liquid of back stir; Described amalgamation liquid is evaporated to relative density 1.10～1.15 (60 ℃) concentrated solution; The ethanol mixture that filters, leaves standstill after 24 hours with 10 times of amounts soaked 10 days, in the medical spray gun of packing into.Can directly spray the affected part during use.One day three times.

Pharmacodynamic study of the present invention and toxicity (is example with the unguentum) research is as follows:

1. skin irritation test

Get rabbit and shave hair, contact test is induced and excited to externally used paste of the present invention, viewing test rabbit after 24 hours and 48 hours, all loseing skin has phenomenons such as erythema and edema, with the negative control group zero difference.The result shows that this unguentum is bordering on zero to skin irritation intensity, does not promptly have skin allergic reaction.

2. cumulative toxicity test report

Test method: select 20 healthy mices for use, female, male each 10, dosage designs per 5 days and is first phase, each issue dosage is respectively oral capsule agent medicine 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, and the LD50 female, male mice of this sample is 5000m part/k part BW (five dosage be 500,750,1100,1700,2500m part/k part BW).Weighed once in per 5 days, and adjusted dosage, press 0.1ml/10 part BW per os and irritate stomach.After 20 days, animal does not have death condition takes place, and off-test is tried thing after 20 days by ascending-dose, and female, buck does not all have death condition and takes place.

3. acute toxicity test

Give white mice feeding dispensing with 200 times of the clinical consumption per day of endo-medicine of the present invention, observe 5 orders.All white mice are strong as a result deposits, and its activity, diet, hair, Excreta are no abnormal, do not see toxic reaction.Irritation test is carried out in white mouse oral cavity and damaged skin, and not seeing has irritative response and other untoward reaction.

Toxicity test proves, not toxic effect of this medicine and untoward reaction, and clinical practice is safe and reliable

4. to the bacteriostasis of common bacterial strain

Solid process antibacterial action: line on blood ware or the ordinary nutrient agar plate so that various test organismss are intensive, punch with the 8mm card punch, every hole adds the about 0.2ml of aseptic reagent, cultivated 18～24 hours down for 37 ℃, observe the size of inhibition zone, with unguentum of the present invention is example, judges its responsive result such as following table.

Bacterial strain	Strain number	100% unguentum	200% unguentum	300% unguentum
					Staphylococcus aureus	M122	--	+++	+++
Staphylococcus albus	M121	-	++++	++++
					Bacillus pyocyaneus	Ps207	-	++	+++
Bacillus proteus	E402	+	++	+++
					Escherichia coli	E100	-	++	++
Bacillus subtilis	63051	+	+++	++
					Diphtheria corynebacterium	C102	+	+++	++++
Diplococcus pneumoniae	M311	-	+++	+++
					Bacillus typhi	E686	++	+++	++++
Paratyphoid bacillus A	50073	++	+++	+
					Bacillus paratyphosus B	50094	+	++	++++
The beta hemolysis streptococcus	M220	++	++++	+++

Antibacterial circle diameter＜9mm., drug resistance-; Antibacterial circle diameter 〉=10～14mm, slight sensitive+; Antibacterial circle diameter 〉=15～19mm, medium sensitivity ++; Antibacterial circle diameter 〉=20～29mm, extremely sensitive +++; Antibacterial circle diameter 〉=30mm, extra-high-speed degree sensitivity ++ ++.

Above extracorporeal bacteria inhibitor test shows that this product truly has the obvious suppression effect to common antibacterial, fungus.

Embodiment 1: Chen, man, 28 years old, patient main suit: because of swimming to the natatorium, play irregular erythema at the rib place after 2 days, continuous then occur in groups that the foxtail millet grain immediately becomes blister to the big pimple of Semen phaseoli radiati, transparent clarification, Chi Bubi is shinny, blush on every side, the affected part pain of itching has burning sensation, is difficult to stand.Hospital treatment is diagnosed as the fungoid skin infection, gives Calamine Lotion, flat outer the smearing of dermatosis, and the intramuscular injection vitamin B6 is invalid.Seeking medical advice to here in the back, uses following prescription:

Endo-medicine is: Radix Salviae Miltiorrhizae 10g, Caulis Spatholobi 10g, Flos Campsis 10g, Radix Angelicae Sinensis 10g, Radix Astragali 10g, Cortex Moutan 15g, Semen Persicae 10g, Flos Lonicerae 20g, Herba Violae 20g;

External used medicine is: Fructus Cnidii 15g, Indigo Naturalis 10g, Hedyotidis Diffusae 10g, Fructus Kochiae 15g, Cortex Dictamni 10g, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 5g, Radix Stemonae 20g, Herba Portulacae 15g, Radix Sophorae Flavescentis 10g, Radix Arnebiae (Radix Lithospermi) 10g, dried Alumen 10g, Herba Houttuyniae 10g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 15g.

The endo-medicine external used medicine is used.External used medicine is made unguentum and is smeared.Unguentum is smeared in the affected part, medication alleviation of pain of itching on the 1st, and blister disappeared on 3rd, incrustation recovery from illness on the 7th.Follow up a case by regular visits to after half a year and do not have recurrence.

Embodiment 2: gold certain, the man, 31 years old, patient main suit: patient foot often itched and gets blister, and scratches the flowing water erosion, the sole scurf of having itched, 6 years.Be beriberi after diagnosing.Smear daktarin, effect such as sufficient moss is clean is not obvious, easily outbreak repeatedly.Come here to go to a doctor, use external medication of the present invention.

External used medicine is: Fructus Cnidii 15g, Indigo Naturalis 10g, Hedyotidis Diffusae 20g, Fructus Kochiae 15g, Cortex Dictamni 10g, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 5g, Radix Stemonae 20g, Herba Portulacae 20g, Radix Sophorae Flavescentis 10g, Radix Arnebiae (Radix Lithospermi) 10g, dried Alumen 10g, Herba Houttuyniae 20g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 15g.

Making unguentum smears every day.Further consultation patient skin lesion is clearly better after 7 days, and no erosion is oozed out, and still has slight pruritus.Continue to use scratchiness disappearance after 7 days, recovery from illness in 2 months.Follow up a case by regular visits to and do not have recurrence in 1 year.

Embodiment 3: the side certain, woman, 28 years old.Patient's readme family keeps a pet, one of baffled erythema of right in this year arm, and scratchiness is strong, plays scurf, aggravates 10 days.The desire that holds a sinecure is depressed, big dry stool.Have a medical check-up: it is coarse to see that right arm place inside skin thickens, desquamation, and pigment is darker, and obvious scratch is arranged.Tongue tip side of red, yellow and greasy fur, thready and rapid pulse.Be diagnosed as: antibacterial or dermatomycosis.Treat with following prescription:

Endo-medicine is: Radix Salviae Miltiorrhizae 15g, Caulis Spatholobi 20g, Flos Campsis 10g, Radix Angelicae Sinensis 20g, Radix Astragali 10g, Cortex Moutan 15g, Semen Persicae 15g, Flos Lonicerae 15g, Herba Violae 15g;

External used medicine is: Fructus Cnidii 15g, Indigo Naturalis 10g, Hedyotidis Diffusae 15g, Fructus Kochiae 15g, Cortex Dictamni 15g, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 5g, Radix Stemonae 20g, Herba Portulacae 15g, Radix Sophorae Flavescentis 10g, Radix Arnebiae (Radix Lithospermi) 10g, dried Alumen 10g, Herba Houttuyniae 20g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 15g.

Endo-medicine and external used medicine are used, and 3d aftersensation pruritus obviously alleviates, and is clearly better behind the 5d.Transference cure after one month is followed up a case by regular visits to not recurrence in 1 year.

Embodiment 4: Gong, the woman, 35 years old, patient's readme before one month no obvious inducement body play erythra, pruritus is serious, scratch the back flowing water, Drug therapys such as oral ketoboidies sweet smell, the external Pevisone, PIYANPING is not seen obvious curative effects.Patient skin pruritus during prescription on individual diagnosis, vexed insomnia, yellow urine, big dry stool.Indagation: trunk, extremity are dispersed in erythema, and vesicle is symmetrically distributed indefinite border.Skin lesions circumferece is dispersed in the scratch incrustation.Red tongue, yellow and greasy fur, wiry and frequent pulse.Western medicine diagnose: antibacterial or dermatomycosis.Dialectical: damp and hot laying equal stress on.Method of treatment: removing damp-heat, removing pathogenic heat from blood and toxic substance from the body.Use following prescription treatment:

Endo-medicine is: Radix Salviae Miltiorrhizae 15g, Caulis Spatholobi 20g, Flos Campsis 10g, Radix Angelicae Sinensis 10g, Radix Astragali 20g, Cortex Moutan 15g, Semen Persicae 20g, Flos Lonicerae 20g, Herba Violae 20g;

External used medicine is: Fructus Cnidii 20g, Indigo Naturalis 10g, Hedyotidis Diffusae 20g, Fructus Kochiae 15g, Cortex Dictamni 15g, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 5g, Radix Stemonae 20g, Herba Portulacae 15g, Radix Sophorae Flavescentis 10g, Radix Arnebiae (Radix Lithospermi) 10g, dried Alumen 15g, Herba Houttuyniae 20g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 20g.

Endo-medicine and external used medicine are used, and pruritus obviously alleviates after 5 days, and pruritus disappears after 10 days, continue to use one month recovery from illness.Follow up a case by regular visits to and do not recur half a year.

This clinical trial is totally 58 examples.Women's 30 examples, male's 28 examples; 18～50 years old age, average 26.91 years old; The course of disease 4 week～9 year, average 2.01; Skin lesion classification (degree), I level 27 examples, II level 22 examples, III level 7 examples, IV level 2 examples.

Grouping situation: be divided into 2 groups at random.1 group of women's 13 example wherein, male's 10 examples; 18～38 years old age, average 23.75 years old; Course of disease week～9 year, average 1.28; Skin lesion classification (degree), I level 7 examples, II level 9 examples, III level 5 examples, IV level 2 examples.

2 groups of women's 12 examples, male's 13 examples.20～40 years old age; Average 23.75 years old; The course of disease 2 week～4 year, average 0.96.Skin lesion classification (degree), I level 12 examples, II level 11 examples, III level 2 examples.

Clinical efficacy: I organizes 28 examples, 4 examples of fully recovering, and produce effects 16 examples, effective 6 examples, invalid 2 examples, total effective rate (basic+produce effects+effectively) 92.86%; Cutaneous inflammatory lesion 2 examples of fully recovering, produce effects 14 examples, effective 7 examples, invalid 5 examples, total effective rate 82.14%; Non-inflammatory skin lesion 0 example of fully recovering, produce effects 13 examples, effective 8 examples, invalid 7 examples, total effective rate 85.03%.II organizes 30 examples, 3 examples of fully recovering, produce effects 12 examples, effective 11 examples, invalid 4 examples, total effective rate 86.70%; The cutaneous inflammatory lesion base is 5 examples more, produce effects 10 examples, effective 7 examples, invalid 8 examples, total effective rate 73.33%; Non-inflammatory skin lesion 0 example of fully recovering, produce effects 7 examples, effective 13 examples, invalid 10 examples, total effective rate 78.67%.Two groups are carried out general curative effect, struvite skin lesion, non-inflammation erythra statistical analysis respectively relatively, and through " Riditi " statistical analysis relatively, all there are no significant greater than 0.05, two group of difference for 3 P values as a result.

Claims (8)

1. a Chinese medicine composition for the treatment of antibacterial or dermatomycosis is characterized in that, form by endo-medicine and external used medicine,

The ratio of weight and number of making the various crude drug of described endo-medicine is: 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Caulis Spatholobis, 10～20 parts of Flos Campsiss, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the Radixs Astragali, 10～20 parts of Cortex Moutans, 10～20 parts in Semen Persicae, 10～20 parts of Flos Loniceraes, 10～20 parts of Herba Violae;

The ratio of weight and number of making the various crude drug of described external used medicine is: 10～30 parts of Fructus Cnidiis, 10～30 parts of Indigo Naturaliss, 10～30 parts of Hedyotidis Diffusaes, 10～30 parts of the Fructus Kochiae, 10～30 parts of Cortex Dictamni, 5～10 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 10～30 parts of the Radixs Stemonae, 10～30 parts of Herba Portulacaes, 10～30 parts of Radix Sophorae Flavescentiss, 10～30 parts of Radix Arnebiae (Radix Lithospermi)s, 10～30 parts of dried Alumens, 10～30 parts of Herba Houttuyniae, 10～30 parts on Cortex cinnamomi japonici (Ramulus Cinnamomi).

2. according to the described Chinese medicine composition for the treatment of antibacterial or dermatomycosis of claim 1, it is characterized in that, the ratio of weight and number of making the various crude drug of described endo-medicine is: 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Caulis Spatholobis, 10～15 parts of Flos Campsiss, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of the Radixs Astragali, 10～15 parts of Cortex Moutans, 10～15 parts in Semen Persicae, 10～15 parts of Flos Loniceraes, 10～15 parts of Herba Violae;

The ratio of weight and number of making the various crude drug of described external used medicine is: 10～20 parts of Fructus Cnidiis, 10～20 parts of Indigo Naturaliss, 10～20 parts of Hedyotidis Diffusaes, 10～20 parts of the Fructus Kochiae, 10～20 parts of Cortex Dictamni, 5～10 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 10～20 parts of the Radixs Stemonae, 10～20 parts of Herba Portulacaes, 10～20 parts of Radix Sophorae Flavescentiss, 10～20 parts of Radix Arnebiae (Radix Lithospermi)s, 10～20 parts of dried Alumens, 10～20 parts of Herba Houttuyniae, 10～20 parts on Cortex cinnamomi japonici (Ramulus Cinnamomi).

3. according to the described Chinese medicine composition for the treatment of antibacterial or dermatomycosis of claim 1, it is characterized in that, the ratio of weight and number of making the various crude drug of described endo-medicine is: 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Caulis Spatholobis, 10～20 parts of Flos Campsiss, 10～20 parts of Radix Angelicae Sinensis, 10～15 parts of the Radixs Astragali, 10～15 parts of Cortex Moutans, 10～15 parts in Semen Persicae, 10～15 parts of Flos Loniceraes, 10～15 parts of Herba Violae;

The ratio of weight and number of making the various crude drug of described external used medicine is: 10～25 parts of Fructus Cnidiis, 10～25 parts of Indigo Naturaliss, 10～25 parts of Hedyotidis Diffusaes, 10～25 parts of the Fructus Kochiae, 10～25 parts of Cortex Dictamni, 5～10 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 10～25 parts of the Radixs Stemonae, 10～25 parts of Herba Portulacaes, 10～25 parts of Radix Sophorae Flavescentiss, 10～25 parts of Radix Arnebiae (Radix Lithospermi)s, 10～25 parts of dried Alumens, 10～25 parts of Herba Houttuyniae, 10～25 parts on Cortex cinnamomi japonici (Ramulus Cinnamomi).

4. according to the described Chinese medicine composition for the treatment of antibacterial or dermatomycosis of claim 1, it is characterized in that, the ratio of weight and number of making the various crude drug of described endo-medicine is: 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Caulis Spatholobis, 10～15 parts of Flos Campsiss, 10～15 parts of Radix Angelicae Sinensis, 10～20 parts of the Radixs Astragali, 10～20 parts of Cortex Moutans, 10～20 parts in Semen Persicae, 10～20 parts of Flos Loniceraes, 10～20 parts of Herba Violae;

The ratio of weight and number of making the various crude drug of described external used medicine is: 15～30 parts of Fructus Cnidiis, 15～30 parts of Indigo Naturaliss, 15～30 parts of Hedyotidis Diffusaes, 15～30 parts of the Fructus Kochiae, 15～30 parts of Cortex Dictamni, 5～10 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 15～30 parts of the Radixs Stemonae, 15～30 parts of Herba Portulacaes, 15～30 parts of Radix Sophorae Flavescentiss, 15～30 parts of Radix Arnebiae (Radix Lithospermi)s, 15～30 parts of dried Alumens, 15～30 parts of Herba Houttuyniae, 15～30 parts on Cortex cinnamomi japonici (Ramulus Cinnamomi).

5. according to the Chinese medicine composition of each described treatment antibacterial or dermatomycosis in the claim 1～4, it is characterized in that described endo-medicine is fried in shallow oil decoction in use and taken, 1 dose of every day, decocting is obeyed at twice, and per 7 days is a course of treatment.

6. according to each described Chinese medicine composition for the treatment of antibacterial or dermatomycosis in the claim 1～4, it is characterized in that, the dosage form of described endo-medicine is a capsule, and its preparation method may further comprise the steps: described crude drug is added 10 times of amounts of weight ethanol, heating and refluxing extraction 3 times, each 2 hours, 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, behind the sucking filtration, when the relative density of filtrate is 20 ℃ 1.08; Described filtrate flow is the macroporous adsorptive resins of 10L through volume, use the deionized water or the distilled water eluting of 10 times of resin column volumes afterwards, 95% ethanol elution of 5 times of resin column volumes of reuse, collect ethanol elution, remove alcohol solvent, obtain component medicated powder, incapsulate and be made as capsule, every capsules dress 0.4g

Described external used medicine is a unguentum, and its preparation method may further comprise the steps:

According to described portion rate with Fructus Cnidii and the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) with 95% soak with ethanol three times, each soak time was respectively 2 hours, 1.5 hours, 1 hour; Each 80～85 ℃ of heat in back of soaking are extracted; Used ethanol is respectively with the gross weight ratio of Fructus Cnidii, two kinds of medical materials of the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae): for the first time 10 times of amounts, the second time 8 times of amounts, 6 times of amounts for the third time; Merge three times ethanol extract, be concentrated into relative density and be 1.08 concentrated solution, stand for standby use; All the other described crude drug are mixed by proportioning except that dried Alumen, drop into pulverizer and be ground into fine powder, after sieving, puts into fine powder the acid and alkali-resistance infusion kettle, at normal temperatures and pressures, flooded 10～20 days with ethanol is common, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation, and are mixed with aforementioned concentrated solution then; Described mixed liquid heating is concentrated into pasty state, puts into 80 ℃ of oven dry of baking oven postcooling, grind to form fine-powdered, mix vaseline and make unguentum with dried Alumen is mixed.

7. one kind as the preparation method of the Chinese medicine composition of treatment antibacterial or dermatomycosis as described in each in the claim 1～4, it is characterized in that described external used medicine is the gel dosage form, and the step of preparation comprises:

Described medicine shredded except that dried Alumen join in the multi-function extractor, add ratio of weight and number and be 3000 parts water logging bubble 30～40 minutes, decocts after 1.5 hours, it is standby to take out first time decoction liquor; Medicinal residues adding ratio of weight and number is after 3000 parts decocting boils 1 hour, take out decoction liquor for the second time, twice decoction liquor merged filtration, it is 1000 parts solution that filtrate decompression is concentrated into ratio of weight and number, staticly settled 24～36 hours, and drew supernatant, be heated to that to add ratio of weight and number after 40～50 ℃ be 2 parts the ethyl hydroxybenzoate and the dried Alumen of porphyrize, stir, under normal pressure, be condensed into ratio of weight and number and be 500 parts concentrated solution; Carbomer-940 and the ratio of weight and number that with ratio of weight and number is 15 parts is that the distilled water that 3 parts Tween-80 and ratio of weight and number are 200 parts mixes, be that to be dissolved in ratio of weight and number be in 300 parts the distilled water for 15 parts triethanolamine then with ratio of weight and number, add aforementioned mixed liquor, 45 parts the propylene glycol that adds ratio of weight and number after stirring, be that 500 parts concentrated solution mixes at last with described ratio of weight and number, stir

The dosage form of described endo-medicine is a capsule, its preparation method may further comprise the steps: described crude drug is added 10 times of amounts of weight ethanol, heating and refluxing extraction 3 times, each 2 hours, 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, behind the sucking filtration, when the relative density of filtrate is 20 ℃ 1.08; Described filtrate flow is the macroporous adsorptive resins of 10L through volume, use the deionized water or the distilled water eluting of 10 times of resin column volumes afterwards, 95% ethanol elution of 5 times of resin column volumes of reuse, collect ethanol elution, remove alcohol solvent, obtain component medicated powder, incapsulate and be made as capsule, every capsules dress 0.4g.

8. one kind as the preparation method of the Chinese medicine composition of treatment antibacterial or dermatomycosis as described in each in the claim 1～4, it is characterized in that described external used medicine dosage form is a spray, and the step of preparation comprises:

According to described portion rate with Fructus Cnidii and the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) with 65% alcohol reflux secondary, the ethanol that adds for the first time 5 times of amounts of Fructus Cnidii and Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) weight sum, refluxed 2 hours, the ethanol that adds for the second time 4 times of amounts of Fructus Cnidii and Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) weight sum, refluxed 2 hours, reclaim ethanol then, filter to get filtrate 1, standby; All the other crude drug are boiled secondary except that dried Alumen adds decocting, add the water of all the other crude drug 8 times of amounts of weight sum except that dried Alumen for the first time, decocted 1.5 hours, the water that adds for the second time all the other crude drug 6 times of amounts of weight sum except that dried Alumen, decocted 1.5 hours, and filtered to get filtrate 2, standby; Above-mentioned filtrate 1, filtrate 2 are merged, dried Alumen is ground in the input amalgamation liquid of back stir; Relative density was 1.10～1.15 concentrated solution when described amalgamation liquid was evaporated to 60 ℃; The ethanol mixture that filters, leaves standstill after 24 hours with 10 times of amounts soaked 10 days, in the medical spray gun of packing into,

The dosage form of described endo-medicine is a capsule, its preparation method may further comprise the steps: described crude drug is added 10 times of amounts of weight ethanol, heating and refluxing extraction 3 times, each 2 hours, 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, behind the sucking filtration, when the relative density of filtrate is 20 ℃ 1.08; Described filtrate flow is the macroporous adsorptive resins of 10L through volume, use the deionized water or the distilled water eluting of 10 times of resin column volumes afterwards, 95% ethanol elution of 5 times of resin column volumes of reuse, collect ethanol elution, remove alcohol solvent, obtain component medicated powder, incapsulate and be made as capsule, every capsules dress 0.4g.