CN105596287B - 主动分离型可溶性微针及其制备方法 - Google Patents
主动分离型可溶性微针及其制备方法 Download PDFInfo
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- CN105596287B CN105596287B CN201610080970.6A CN201610080970A CN105596287B CN 105596287 B CN105596287 B CN 105596287B CN 201610080970 A CN201610080970 A CN 201610080970A CN 105596287 B CN105596287 B CN 105596287B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
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- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
时间 | 1s | 3s | 5s | 8s | 15s |
实施例1 | 2% | 35% | 60% | 75% | 100% |
实施例2 | 1% | 37% | 58% | 80% | 100% |
实施例3 | 1% | 28% | 55% | 67% | 92% |
对比例1 | 0% | 0% | 0% | 0% | 1% |
Claims (9)
Priority Applications (1)
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CN201610080970.6A CN105596287B (zh) | 2016-02-04 | 2016-02-04 | 主动分离型可溶性微针及其制备方法 |
Applications Claiming Priority (1)
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CN201610080970.6A CN105596287B (zh) | 2016-02-04 | 2016-02-04 | 主动分离型可溶性微针及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN105596287A CN105596287A (zh) | 2016-05-25 |
CN105596287B true CN105596287B (zh) | 2018-09-18 |
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CN201610080970.6A Active CN105596287B (zh) | 2016-02-04 | 2016-02-04 | 主动分离型可溶性微针及其制备方法 |
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CN (1) | CN105596287B (zh) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106039552A (zh) * | 2016-05-30 | 2016-10-26 | 北京化工大学 | 一种气泡式微针及其制备方法 |
CN106176573B (zh) * | 2016-08-24 | 2019-06-21 | 湖北大学 | 一种可溶性中空微针及其制备方法 |
CN106727273A (zh) * | 2017-03-02 | 2017-05-31 | 李成国 | 可溶性微针的制造方法 |
TWI629073B (zh) * | 2017-05-16 | 2018-07-11 | 怡定興科技股份有限公司 | Microneedle patch manufacturing method |
CN107233296B (zh) * | 2017-05-27 | 2020-01-07 | 中山大学 | 胸腺五肽可溶性微针及其制备方法 |
CN107096013B (zh) * | 2017-06-09 | 2020-10-27 | 广州新济薇娜生物科技有限公司 | 鲑鱼降钙素可溶性微针贴片及其制备方法 |
CN108524916B (zh) * | 2018-05-31 | 2020-10-30 | 浙江中医药大学 | 一种载中华眼镜蛇神经毒素的可溶性微针的制备方法 |
CN110870846A (zh) * | 2018-08-31 | 2020-03-10 | 中科微针(北京)科技有限公司 | 一种可快速植入型缓释微针贴片及其制备方法 |
CN110917176B (zh) * | 2018-08-31 | 2021-03-30 | 中科微针(北京)科技有限公司 | 一种可植入型缓释微针贴片及其制备方法 |
CN111494237A (zh) * | 2020-04-30 | 2020-08-07 | 重庆福特尔科技有限公司 | 可溶性微针贴 |
CN113288882A (zh) * | 2021-04-12 | 2021-08-24 | 南方科技大学 | 一种快速分离微针贴片及其制备方法 |
CN113041212B (zh) * | 2021-04-25 | 2023-10-31 | 陕西师范大学 | 一种自组装凝胶祛痘微针贴片及其的制备方法和应用 |
CN113244162B (zh) * | 2021-05-24 | 2022-08-02 | 杭州荔枝红生物科技有限公司 | 一种可溶性微针及其制备方法和在制备调节皮肤微生态产品中的应用 |
CN114288277B (zh) * | 2021-12-31 | 2024-05-14 | 广州新济生物医药研究院有限公司 | 一种机械性能和渗透增强的微针贴片及其制备方法 |
CN114569583B (zh) * | 2022-03-14 | 2023-10-17 | 中山大学 | 一种快速分离型脂质体复合缓释微针及其制备方法 |
Citations (5)
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CN104027324A (zh) * | 2013-03-06 | 2014-09-10 | 中国科学院理化技术研究所 | 一种可溶性微针疫苗贴片及其制备方法 |
CN104057564A (zh) * | 2014-06-06 | 2014-09-24 | 游学秋 | 基于倾斜铸模的微针制作方法 |
CN104069585A (zh) * | 2014-07-03 | 2014-10-01 | 游学秋 | 可分离式微针***及其制造方法 |
CN104411207A (zh) * | 2012-06-29 | 2015-03-11 | Elc管理有限责任公司 | 包含一种或多种包封化妆品成分的可溶解微针 |
CN104706626A (zh) * | 2015-03-25 | 2015-06-17 | 北京化工大学 | 一种便于动物疫苗给药的微针贴片及其制备方法 |
Family Cites Families (3)
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---|---|---|---|---|
WO2010078323A1 (en) * | 2008-12-29 | 2010-07-08 | Sung-Yun Kwon | Method of manufacturing solid solution peforator patches and uses thereof |
GB201107642D0 (en) * | 2011-05-09 | 2011-06-22 | Univ Cork | Method |
TWI554289B (zh) * | 2012-06-29 | 2016-10-21 | 國立成功大學 | 鑲嵌式經皮藥物釋放貼片及其製造方法 |
-
2016
- 2016-02-04 CN CN201610080970.6A patent/CN105596287B/zh active Active
Patent Citations (5)
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CN104411207A (zh) * | 2012-06-29 | 2015-03-11 | Elc管理有限责任公司 | 包含一种或多种包封化妆品成分的可溶解微针 |
CN104027324A (zh) * | 2013-03-06 | 2014-09-10 | 中国科学院理化技术研究所 | 一种可溶性微针疫苗贴片及其制备方法 |
CN104057564A (zh) * | 2014-06-06 | 2014-09-24 | 游学秋 | 基于倾斜铸模的微针制作方法 |
CN104069585A (zh) * | 2014-07-03 | 2014-10-01 | 游学秋 | 可分离式微针***及其制造方法 |
CN104706626A (zh) * | 2015-03-25 | 2015-06-17 | 北京化工大学 | 一种便于动物疫苗给药的微针贴片及其制备方法 |
Non-Patent Citations (4)
Title |
---|
Dissolving Microneedles for Transdermal Drug Delivery;Jeong Woo Lee et al;《Biomaterials》;20080531;第29卷(第13期);第2113-2124页 * |
Fully embeddable chitosan microneedles as a sustained release depot for intradermal vaccination;Mei-Chin Chen et al;《Biomaterials》;20130128;第34卷;第3077-3086页 * |
Microneedles for drug and vaccine delivery;Yeu-Chun Kim et al;《Advanced Drug Delivery Reviews》;20120501;第64卷;第1547-1568页 * |
Separable Arrowhead Microneedles;Leonard Y. Chu et al;《J Control Release》;20110210;第149卷(第3期);第242-249页 * |
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CN105596287A (zh) | 2016-05-25 |
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Effective date of registration: 20181025 Address after: 510006 room 226, 1 building, Guangdong Pharmaceutical University, 280 Panyu District Road, Panyu District, Guangdong. Patentee after: GUANGZHOU XINJI WEINA BIOTECHNOLOGY CO.,LTD. Address before: 510660 room 503, 262 Zhongshan Avenue, Tianhe District, Guangzhou, Guangdong. Patentee before: NEWORLD PHARMACEUTICAL Co.,Ltd. |
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