CN105535679B - A kind of probiotics ferment restoration of the ecosystem composition - Google Patents
A kind of probiotics ferment restoration of the ecosystem composition Download PDFInfo
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- CN105535679B CN105535679B CN201511029169.0A CN201511029169A CN105535679B CN 105535679 B CN105535679 B CN 105535679B CN 201511029169 A CN201511029169 A CN 201511029169A CN 105535679 B CN105535679 B CN 105535679B
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Abstract
A kind of probiotics ferment restoration of the ecosystem composition is aided with a variety of Chinese herbal medicines such as Radix Angelicae Sinensis and food materials and carries out aerobic fermentation, anaerobic fermentation, and filtrate fat of Oromaius norvaehollandeae, badger seed oil and house oil is added using centella as primary raw material, homogenization and it is manufactured.The composition of the present invention can expand Skin Cell gap, dredge pore, relaxation sweat duct, promote the nutritional benefit substance in a large amount of absorbing compositions of skin, to play modification, moisturizing, moisturizing, the special role for improving immunity, skin can be quickly repaired, has positive effect to scald, wound infection and scar reparation.
Description
Technical field
The present invention relates to pharmaceutical technology fields, and in particular to a kind of probiotics ferment restoration of the ecosystem composition can quickly have
Repair skin trauma in effect ground.
Background technology
Skin is one of the maximum organ of human body area and most important organ, plays protection organ, resists outside
The external substance that the intrusion of microorganism and bacterium etc., the adjusting for participating in body temperature, perception touch in portion's environment.Skin trauma is general
It is divided into two aspects of external cause and internal cause.External cause refers to external influence in the Risk Factors of human body.Internal cause, which refers to inside of human body, to be influenced
And the factor of damage is caused, such as age, constitution, topography internal factor.It is relatively common in general daily life to have
It hurts, scald, stab.
Skin surface is in brick wall structure state, although can play the role of resisting bacterial disease invasion, is also hindered simultaneously
Nutriment is absorbed and utilized.Skin ultrastructure is a kind of process of complexity, in this course, different cells, thin
There are complicated relationships between intracellular cytokine and extracellular matrix.The treatment means of current clinical medicine, skin injury are main
It is to pass through local treatment.The preparations such as protective agent, antibiotic, vitamin and trace element promote the effect of wound healing extremely to have
Limit, because base rests essentially within the stage for waiting for surface of a wound normal healing.Although some growth factors have stronger thin by promoting
Born of the same parents are proliferated and promote the effect of wound healing, but since the healing of the surface of a wound needs a variety of growth factors to participate in jointly, compatibility is complicated,
And cell hyperproliferation is likely to form hyperplastic scar or even causes canceration, so its safety is always of people's attention
Emphasis.
Traditional Chinese medical herbal treatment skin injury is with a long history, for how to promote wound repair in relation to unique understanding and enrich
Experience.Chinese medicine external is that " promoting flow of qi and blood circulation pushes away Chen Zhixin, eliminating dampness receipts purulence, apocenosis to promoting the primary treatment principle of injury repair
Myogenic, sour and astringent closing in, promoting granulation and wound healing ".Currently, being mostly used in the external application Chinese medicine for the treatment of skin trauma only by several kinds of Chinese medicinal materials
It compounds, there is no pass through special processing.Although these Chinese medicines can repair trauma skin, repair time compares
It is long, it can not achieve the effect that quickly to repair.
Invention content
It is an object of the invention to overcome the defect of the above-mentioned prior art, a kind of probiotics ferment restoration of the ecosystem combination is provided
Object ferments to several kinds of Chinese medicinal materials using composite bacteria and is made, and skin trauma can be quickly repaired, including scalds, stabs, hinders
Mouthfeel dye, scar reparation.
In order to achieve the above objectives, the present invention adopts the following technical scheme that：
A kind of probiotics ferment restoration of the ecosystem composition, it is characterised in that be made with the following method：
It is prepared by S1, zymocyte liquid：Percentage takes pure water 80~90%, and composite bacteria 2~8% is added, then
Addition oligofructose 4~9%, albumen powder 1~5% are mixed thoroughly, and zymocyte liquid is made；
S2：Raw material soaking：30~50 parts of centella, 5~10 parts of fig, 5~10 parts of red pomegranate, Du are taken by weight
Cuckoo spend 3~8 parts, 1~4 part of the root of Dahurain angelica, 3~5 parts of Radix Salviae Miltiorrhizae, fiery 3~5 parts of spine, 1~3 part of ginseng, 1~3 part of Radix Angelicae Sinensis, 5~8 parts of aloe,
2~5 parts of hairy euphorbia, 2~5 parts of the seed of jog's tears, 0.5~3 part of schizonepeta, 2~5 parts windproof, 0.5~2 part of silver ear, 1~3 part of giant knotweed, Buddhist
1~3 part of first grass, 2~5 parts of radix ampelopsis, 2~5 parts of Radix Glycyrrhizae, 2~5 parts of purslane are added normal-temperature water cleaning, removal of impurities, then impregnate 1-2
It；
S3：Raw material sterilizes：121 DEG C or more of water vapour is passed through in the raw material of immersion to sterilize；
S4：It is cooled to 30-40 DEG C；
S5：Raw material after sterilizing is inserted into fermentation tank, zymocyte liquid is filled with and ferments；
S6：It is sealed by fermentation 8-10 days under aerobic conditions；
S7：It is sealed by fermentation 18-25 days under anaerobic；
S8：After filtrate is obtained by filtration, by weight, fat of Oromaius norvaehollandeae, the 0.3- that weight is filtrate weight 0.1-0.5% is added
0.5% badger seed oil and the house oil of 0.1-0.3%, homogenization；
The composite bacteria is photosynthetic bacteria, saccharomycete, Lactobacillus delbrueckii, lactobacillus bulgaricus, streptococcus lactis, acidified milk
Three kinds or more mixing in bacillus, lactobacillus curvatus, solidification bacillus, adhesion bacillus, lactobacillus lactis.
Preferably, the temperature of sterilizing is 121 DEG C, and the time is 40~60min.
Preferably, the raw material be calculated as by weight 40 parts of centella, 8 parts of fig, 10 parts of red pomegranate, 5 parts of azalea,
2 parts of the root of Dahurain angelica, fiery 4 parts of spine, 1 part of ginseng, 3 parts of Radix Angelicae Sinensis, 6 parts of aloe, 3 parts of hairy euphorbia, 4 parts of the seed of jog's tears, 1 part of schizonepeta, is prevented 3 parts of Radix Salviae Miltiorrhizae
2 parts of wind, 1 part of centella, 0.5 part of silver ear, 3 parts of giant knotweed, 2 parts of sedum lineare, 5 parts of radix ampelopsis, Radix Glycyrrhizae 2 divide, 4 parts of purslane.
Preferably, the charge of zymocyte liquid is advisable with being slightly above raw material surface.
Preferably, it when aerobic fermentation, is passed through every time before oxygen first by 1-3 cubic metres of oxygen into fermentation tank daily
Fermentation tank is vented.
Preferably, a gas is arranged to fermentation tank daily when anaerobic fermentation.
The present invention also provides the external-applied ointment containing above-mentioned probiotics ferment ecological assemblage object, external plaster, externally applied drugs
Water.
In the present invention, the effect of each raw material is as follows：
Centella：Inducing diuresis and reducing edema with clearing heat and detoxicating, nourishing, anti-inflammatory, quelling effect can stimulate deep skin cell
Substitute, can compact epidermis and corium coupling part, so that skin is limbered up, is smooth flexible；The Asiaticoside contained can treat
Skin ulcer, leprosy.
Fig：Include superoxides, have anti-aging, on the benefits of lengthening one's life.
Red pomegranate：With good toxin expelling, anti-oxidation efficacy.
Azalea：The effect of dry, whitening spot-removing being removed with curing rheumatism, menstruation regulating and blood, tranquilizing the mind.
The root of Dahurain angelica：Microcirculation in human body can be improved, pigment excess accumulation is eliminated, dispel facial colour spot trace trace, treat the grey pain of skin
Mange etc..
Felwort：Either for oral administration or external application, the effect of being all the beauty superfine product of preciousness, while having both whitening and moisturizing.
Ginseng：Tonifying primordial Qi, beneficial Yin and promoting production of body liquid can treat disease of cardiovascular system, diabetes and neurasthenia.
Fiery spine：With whitening curative effect, " histamine " stimulation chromoplast can be inhibited to generate excessive melanin, there is desalination
Magical effect of Mai Laning pigments and moisturizing.
Radix Angelicae Sinensis：Have the function of anti-inflammatory, anticancer, antibacterial, anti-aging, free radical can be removed, improves immunity.
Aloe：It is a kind of perennial Liliaceae fleshiness herbaceous plant, contains vitamin A, vitamin B, vitamin C, dimension
The nutrients such as raw element E, can antibacterial anti-inflammatory, skin care is soaked, containing Aloin A, wound hormone and glycan peptide sweet dew, with disease-resistant
The effect of viral disease infects, and promotion wound healing is restored is the ideal medicament for treating skin injury.
Hairy euphorbia：Annual vegetation can containing chemical compositions such as flavonoid glycoside, gallic acid, taraxerol, alkaloids
Eczema, the ringworm of the foot, pruitus are controlled, has effects that antiallergy, sedation-analgesia, bring down a fever.
The seed of jog's tears：Also known as Job's tears, annual sturdy draft have clearing away heat and eliminating pus, skin-care functional.
Schizonepeta：One of common herbal medicine, alexipyretic can town phlegm, wind-dispelling, cool blood.
It is windproof：With expelling pathogenic wind from the body surface, the effect of expel endogenous wind to relieve convulsion, relieving convulsion.
Silver ear：Replenishing the vital essence and removing heat, cardiac stimulant removing toxic substances, nourishing Yin and moistening lung.
Giant knotweed：With clearing heat and detoxicating, removing blood stasis and analgesics, relieving cough and reducing sputum effect, scald, traumatic injury can be controlled.
Sedum lineare：Heat-clearing is subsided a swelling, removing toxic substances.
Radix ampelopsis：Containing various amino acid needed by human, and content is higher, especially the amino with special pharmacological effect
Acid content is high, the multivitamin simultaneously containing needed by human body such as synanthrin, cellulose, protein, calcium, phosphorus, iron and minerals, tool
There is anti-aging and removes free radical and anticancer
Radix Glycyrrhizae：With anti-inflammatory, anti-allergic effects, while the effect of Induced by Carcinogen tumour growth can also be blocked.
Purslane：It is clearing heat and detoxicating, dissipate blood detumescence.
Fat of Oromaius norvaehollandeae：There is analgesic effect to myalgia.
Badger seed oil：With sterilization, sterilizing function, cytothesis can be promoted.
House oil：Moisturizing promotes vis medicatrix naturae and metabolism, resists color spot, alleviates dermatitis and scald and other effects.
Compared with prior art, the beneficial effects of the invention are as follows：
1, composition of the invention can expand Skin Cell gap, dredge pore, and relaxation sweat duct promotes skin largely to inhale
The nutritional benefit substance in composition is received, to play modification, moisturizing, moisturizing, the special role for improving immunity.
2, formula for raw stock of the invention has clearing heat and detoxicating, sedation-analgesia, apocenosis, viral infection resisting, antiallergy, rush
The effect of being restored into wound healing has effects that preferably to repair, can control scald, traumatic injury, simultaneously to skin trauma
Can also beautifying face and moistering lotion form the micro-ecological environment of a coexistence and co-prosperity, manufactured product contains after the fermentation of composite bacteria
A variety of ferment, protease, amino acid, vitamin have the effect of skin repair, scald reparation, wound infection and scar are repaired, together
When can also anti-aging and remove free radical, can be as the externally applied drug of skin trauma.
3, product of the invention is quickly notable to the repairing effect of skin.
Specific implementation mode
The present invention is described in further detail below by specific embodiment to be clearly understood that the present invention to be protected
The technical solution of shield.
Embodiment 1
A kind of probiotics ferment restoration of the ecosystem composition, is made with the following method：
It is prepared by S1, zymocyte liquid：Percentage takes pure water 85%, and composite bacteria 6% is added, adds low
Fructooligosaccharides 6%, albumen powder 3% is mixed thoroughly, and zymocyte liquid is made；The compound bacteria is photosynthetic bacteria, saccharomycete, lactobacillus fermenti, coagulates
It is mixed Gu bacillus is calculated as 1: 2: 1: 1 by weight；
S2：Raw material soaking：40 parts of centella, 8 parts of fig, 10 parts of red pomegranate, 5 parts of azalea, white is taken by weight
2 parts of the root of Dahurian angelica, 3 parts of Radix Salviae Miltiorrhizae, fiery 4 parts of spine, 1 part of ginseng, 3 parts of Radix Angelicae Sinensis, 6 parts of aloe, 3 parts of hairy euphorbia, 4 parts of the seed of jog's tears, 1 part of schizonepeta, windproof 2
Part, 0.5 part of silver ear, 3 parts of giant knotweed, 2 parts of sedum lineare, 5 parts of radix ampelopsis, Radix Glycyrrhizae 2 divides, 4 parts of purslane, and normal-temperature water cleaning is added, removes
It is miscellaneous, then impregnate 1 day；
S3：Raw material sterilizes：121 DEG C or more of water vapour is passed through in the raw material of immersion to sterilize；
S4：It is cooled to 30-40 DEG C；
S5：Raw material after sterilizing is inserted into fermentation tank, zymocyte liquid is filled with and is sent out until not crossing 2 centimetres of raw material surface
Ferment；
S6：It is sealed by fermentation 10 days under aerobic conditions, 2 cubic metres of oxygen is passed through after arranging a gas daily；
S7：It is sealed by fermentation 25 days under anaerobic, arranges a gas daily；
S8：After filtrate is obtained by filtration, by weight, be added weight be filtrate weight 0.2% fat of Oromaius norvaehollandeae, 0.4% badger
Seed oil and 0.3% house oil, homogenization.
Embodiment 2,
A kind of probiotics ferment restoration of the ecosystem composition, is made with the following method：
It is prepared by S1, zymocyte liquid：Percentage takes pure water 80%, and composite bacteria 8% is added, adds low
Fructooligosaccharides 7%, albumen powder 5% is mixed thoroughly, and zymocyte liquid is made；The compound bacteria be photosynthetic bacteria, saccharomycete, adhesion bacillus,
Lactobacillus lactis is calculated as 1: 2: 1: 1 ratio mixing by weight；
S2：Raw material soaking：50 parts of centella, 5 parts of fig, 8 parts of red pomegranate, 8 parts of azalea, the root of Dahurain angelica are taken by weight
1 part, 4 parts of Radix Salviae Miltiorrhizae, fiery 3 parts of spine, 2 parts of ginseng, 1 part of Radix Angelicae Sinensis, 5 parts of aloe, 5 parts of hairy euphorbia, 2 parts of the seed of jog's tears, 3 parts of schizonepeta, windproof 4
Part, 1.5 parts of silver ear, 2 parts of giant knotweed, 1 part of sedum lineare, 3 parts of radix ampelopsis, Radix Glycyrrhizae 5 divide, 2 parts of purslane, normal-temperature water cleaning is added, removes
It is miscellaneous, then impregnate 2 days；
S3：Raw material sterilizes：121 DEG C or more of water vapour is passed through in the raw material of immersion to sterilize；
S4：It is cooled to 30-40 DEG C；
S5：Raw material after sterilizing is inserted into fermentation tank, zymocyte liquid is filled with and is sent out until not crossing 2 centimetres of raw material surface
Ferment；
S6：It is sealed by fermentation 8 days under aerobic conditions, 3 cubic metres of oxygen is passed through after arranging a gas daily；
S7：It is sealed by fermentation 18 days under anaerobic, arranges a gas daily；
S8：After filtrate is obtained by filtration, by weight, be added weight be filtrate weight 0.1% fat of Oromaius norvaehollandeae, 0.5% badger
Seed oil and 0.1% house oil, homogenization.
Embodiment 3
A kind of probiotics ferment restoration of the ecosystem composition, is made with the following method：
It is prepared by S1, zymocyte liquid：Percentage takes pure water 90%, and composite bacteria 8% is added, adds low
Fructooligosaccharides 4%, albumen powder 6% is mixed thoroughly, and zymocyte liquid is made；The composite bacteria be photosynthetic bacteria, saccharomycete, Lactobacillus delbrueckii,
Lactobacillus bulgaricus, streptococcus lactis mix；
S2：Raw material soaking：30 parts of centella, 10 parts of fig, 5 parts of red pomegranate, 3 parts of azalea, white is taken by weight
4 parts of the root of Dahurian angelica, fiery 5 parts of spine, 3 parts of ginseng, 2 parts of Radix Angelicae Sinensis, 8 parts of aloe, 2 parts of hairy euphorbia, 5 parts of the seed of jog's tears, 0.5 part of schizonepeta, is prevented 5 parts of Radix Salviae Miltiorrhizae
5 parts of wind, 2 parts of silver ear, 1 part of giant knotweed, 3 parts of sedum lineare, 2 parts of radix ampelopsis, Radix Glycyrrhizae 3.5 divide, 5 parts of purslane, be added normal-temperature water cleaning,
Then removal of impurities is impregnated 3 days；
S3：Raw material sterilizes：121 DEG C or more of water vapour is passed through in the raw material of immersion to sterilize；
S4：It is cooled to 30-40 DEG C；
S5：Raw material after sterilizing is inserted into fermentation tank, zymocyte liquid is filled with and is sent out until not crossing 2 centimetres of raw material surface
Ferment；
S6：It is sealed by fermentation 8 days under aerobic conditions, 3 cubic metres of oxygen is passed through after arranging a gas daily；
S7：It is sealed by fermentation 20 days under anaerobic, arranges a gas daily；
S8：After filtrate is obtained by filtration, by weight, be added weight be filtrate weight 0.3% fat of Oromaius norvaehollandeae, 0.3% badger
Seed oil and 0.2% house oil, homogenization.
4 skin scald Experiment on therapy of embodiment
One, experimental method：Take healthy adult ICR mouse 20, after injecting anesthetic, lose hair or feathers at back, at depilation for 1cm ×
1cm is randomly divided into blank group and experimental group, every group of 10 mouse, blank group is not administered, and experimental group applies 3 daily after back is scalded
Ecology modification composition, observes time and the rate that scabs of scabbing, and record result made from secondary embodiment 1.
Two, experimental result
For those skilled in the art, technical solution that can be as described above and design are made other each
Kind is corresponding to be changed and deforms, and all these change and deform the protection model that should all belong to the claims in the present invention
Within enclosing.
Claims (7)
1. a kind of probiotics ferment restoration of the ecosystem composition for repairing skin trauma, it is characterised in that make with the following method
At：
It is prepared by S1, zymocyte liquid：Percentage takes pure water 80~90%, and composite bacteria 2~8% is added, adds
Oligofructose 4~9%, albumen powder 1~5% are mixed thoroughly, and zymocyte liquid is made；
S2：Raw material soaking：30~50 parts of centella, 5~10 parts of fig, 5~10 parts of red pomegranate, azalea are taken by weight
3~8 parts, 1~4 part of the root of Dahurain angelica, 3~5 parts of Radix Salviae Miltiorrhizae, fiery 3~5 parts of spine, 1~3 part of ginseng, 1~3 part of Radix Angelicae Sinensis, 5~8 parts of aloe, fly upward
2~5 parts of grass, 2~5 parts of the seed of jog's tears, 0.5~3 part of schizonepeta, 2~5 parts windproof, 0.5~2 part of silver ear, 1~3 part of giant knotweed, sedum lineare 1
~3 parts, 2~5 parts of radix ampelopsis, 2~5 parts of Radix Glycyrrhizae, 2~5 parts of purslane, be added normal-temperature water cleaning, removal of impurities, then impregnate 1-2 days；
S3：Raw material sterilizes：121 DEG C or more of water vapour is passed through in the raw material of immersion to sterilize；
S4：It is cooled to 30-40 DEG C；
S5：Raw material after sterilizing is inserted into fermentation tank, zymocyte liquid is filled with and ferments；
S6：It is sealed by fermentation 8-10 days under aerobic conditions；
S7：It is sealed by fermentation 18-25 days under anaerobic；
S8：After filtrate is obtained by filtration, by weight, fat of Oromaius norvaehollandeae, the 0.3-0.5% that weight is filtrate weight 0.1-0.5% is added
Badger seed oil and 0.1-0.3% house oil, homogenization；
The composite bacteria is photosynthetic bacteria, saccharomycete, Lactobacillus delbrueckii, lactobacillus bulgaricus, streptococcus lactis, acidified milk bar
Three kinds or more mixing in bacterium, lactobacillus curvatus, solidification bacillus, adhesion bacillus, lactobacillus lactis.
2. the probiotics ferment restoration of the ecosystem composition as described in claim 1 for repairing skin trauma, it is characterised in that：
The temperature of sterilizing is 121 DEG C, and the time is 40~60min.
3. the probiotics ferment restoration of the ecosystem composition as described in claim 1 for repairing skin trauma, it is characterised in that：
The raw material is calculated as 40 parts of centella, 8 parts of fig, 10 parts of red pomegranate, 5 parts of azalea, 2 parts of the root of Dahurain angelica, Radix Salviae Miltiorrhizae 3 by weight
Part, fiery 4 parts of spine, 1 part of ginseng, 3 parts of Radix Angelicae Sinensis, 6 parts of aloe, 3 parts of hairy euphorbia, 4 parts of the seed of jog's tears, 1 part of schizonepeta, 2 parts windproof, centella 1
Part, 0.5 part of silver ear, 3 parts of giant knotweed, 2 parts of sedum lineare, 5 parts of radix ampelopsis, Radix Glycyrrhizae 2 divides, 4 parts of purslane.
4. the probiotics ferment restoration of the ecosystem composition as described in claim 1 for repairing skin trauma, it is characterised in that：
The charge of zymocyte liquid is advisable with being slightly above raw material surface.
5. the probiotics ferment restoration of the ecosystem composition as described in claim 1 for repairing skin trauma, it is characterised in that：
When aerobic fermentation, daily into fermentation tank by 1-3 cubic metres of oxygen, it is passed through before oxygen and fermentation tank is vented every time first.
6. the probiotics ferment restoration of the ecosystem composition as described in claim 1 for repairing skin trauma, it is characterised in that：
A gas is arranged to fermentation tank daily when anaerobic fermentation.
7. containing the probiotics ferment restoration of the ecosystem composition for repairing skin trauma described in claim 1 to 6 any one
External-applied ointment, external plaster, lotion.
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| CN110051589B (en) * | 2019-05-17 | 2022-03-08 | 广西冠硕科技有限公司 | Traditional Chinese medicine mask and preparation method thereof |
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| CN111450126B (en) * | 2020-03-31 | 2023-03-14 | 中国人民解放军空军军医大学 | New application of lactobacillus delbrueckii |
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