CN105535580A - A biological agent for improving human body intestinal floras and a preparing method thereof - Google Patents
A biological agent for improving human body intestinal floras and a preparing method thereof Download PDFInfo
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Abstract
The invention relates to a biological agent for improving human body intestinal floras and a preparing method thereof. The biological agent comprises 45-68 parts by weight of lactic acid bacteria, 30-50 parts by weight of isomerized lactose powder, 20-50 parts by weight of apple vinegar, 30-50 parts by weight of ferment and 10-30 parts by weight of dietary fiber. The biological agent is prepared by fully mixing the acetic acid bacteria, the apple vinegar and the dietary fiber by stirring, adding the isomerized lactose powder and the ferment, continuously stirring and mixing for 30-45 min, and sterilizing. Compared with the prior art, the biological agent is simple in composition and is capable of effectively promoting increase of bifidobacteria which are beneficial bacteria in intestinal tracts, allowing the lactic acid bacteria and the bifidobacteria to increase in a balance manner and inhibiting growth of putrefying bacteria and pathogenic bacteria, thus effectively balancing beneficial floras in the intestinal tracts. The biological agent is simple in preparing process, rapid in production of desired effects, wide in suitable population, low in medicine using amount, less in side effects, high in stability, long in shelf life, convenient in medicine taking, easy to carry, low in cost and suitable for large-scale production.
Description
Technical field
The invention belongs to biologic product technology field, relate to a kind of for biological preparation improving human body intestinal canal flora and preparation method thereof.
Background technology
Society now, along with the change of dietary structure, animal group food intake ratio increases substantially, and dietary fiber intake reduces; The absorption raising of high heat fat, alcoholic drink take in improve, drug dependence these situations such as generally, all cause the confusion of human body intestinal canal flora.And intestinal microbial population confusion directly results in function of intestinal canal disorder, cause a series of physiological deceases such as the constipation of human body, diarrhoea, enterospasm, and these physiological deceases can cause the eliminating of vivotoxin to produce obstacle, in body, too much lipometabolic decomposition is discharged and is produced disorder, and these factors can cause, and body immunity declines, hepatic and renal function is disorderly, the physiological problem of body edema obesity.
Application number be 201110034067.3 Chinese invention patent disclose a kind of compound hippophae rhamnoides tea formulation with regulating intestinal canal flora function, this compound hippophae rhamnoides tea formulation counts by weight percentage and comprises: oligofructose 15%-90%, oligomeric isomaltose 0%-40%, oligomeric galactose 0%-30%, seabuckthorn fruit powder 1%-60%, black tea powder 1%-60%, adjuvant 0%-50%.The technical scheme of above-mentioned patent disclosure mainly carrys out component design composition based on teabag drink angle, the bacillus bifidus of intestinal is increased by oligofructose, and suppress the growth of the harmful bacteria such as bacteroid, clostridium, and then maintain human body intestinal canal flora balance, but technique scheme is main still as a kind of health tea beverage, it has certain facilitation to the balance maintaining human body intestinal canal flora, and the physiological problem that intestinal microbial population fundamentally can not be solved chaotic and cause.
Summary of the invention
Object of the present invention is exactly provide one can effective regulating intestinal canal flora to overcome defect that above-mentioned prior art exists, loosening bowel to relieve constipation, promote gastrointestinal motility, and promote vivotoxin to discharge for biological preparation improving human body intestinal canal flora and preparation method thereof.
Object of the present invention can be achieved through the following technical solutions:
For improving a biological preparation for human body intestinal canal flora, this biological preparation comprises following component and weight portion content: lactobacillus 45-68 part, isomerized lactose powder 30-50 part, apple vinegar 20-50 part, ferment 30-50 part and dietary fiber 10-30 part.
The viable count of described lactobacillus is 500-1000 hundred million/g.
Effective ingredient >=97% of described isomerized lactose powder.
Described ferment within 72 hours, is prepared from by culture medium inoculated Lactobacillus plantarum, Bifidobacterium lactis, bacillus acidophilus's mixed culture fermentation, wherein, described culture medium comprises following component and weight portion content: apple powder 20-30 part, orange powder 20-30 part, oatmeal 20-30 part and Rhizoma amorphophalli powder 20-30 part.
In described culture medium, the inoculum concentration of Lactobacillus plantarum is 150-400 hundred million/gram, and the inoculum concentration of Bifidobacterium lactis is 150-400 hundred million/gram, and the inoculum concentration of bacillus acidophilus is 150-400 hundred million/gram.
Described dietary fiber is water soluble dietary fiber.
Described water soluble dietary fiber comprise in pectin, oligofructose, oligomeric isomaltose, oligomeric lactose or oligomeric xylose one or more.
The instructions of taking of described biological preparation is: at 1-2 hour after meal every day took 500-600mg.
For improving a preparation method for the biological preparation of human body intestinal canal flora, the method specifically comprises the following steps:
(1) get the raw materials ready by following component and weight portion:
Lactobacillus 45-68 part, isomerized lactose powder 30-50 part, apple vinegar 20-50 part, ferment 30-50 part and dietary fiber 10-30 part;
(2) by weight lactobacillus, apple vinegar and dietary fiber are fully uniformly mixed, then add isomerized lactose powder, ferment, continue to be uniformly mixed 30-45min, by sterilizing, i.e. obtained biological preparation.
Gained biological preparation of the present invention also can be processed into tablet, granule, pill, powder, suck agent or powder.
In the present invention, carbohydrate fermentation can be become lactic acid by described lactobacillus, make the formation of intestinal microbial population that useful change occur, improve human gastrointestinal tract function, recover colony balance in human body intestinal canal, form antibacterial biological barrier, safeguard health, the breeding of putrefaction bacteria can also be suppressed simultaneously, clear up the toxin that putrefaction bacteria produces, remove intestinal rubbish.
The sugared source that during described isomerized lactose powder, in human body intestinal canal, probiotics bacillus bifidus is best, it is not decomposed at little enteral, move on to large enteral to be utilized by all bacillus bifiduss, bacillus bifidus is made to increase the growth of preponderate, suppress Putrefying bacteria and pathogen, to change intestinal flora, keep intestinal normal function, aging resistance etc. of preventing and curing diseases plays an important role, and isomerized lactose anti-treat constipation and anti-cancer efficacy also very remarkable.Enteral bacillus bifidus is bred, and pH value reduces, and facilitate the wriggling of intestinal, make feces deliquescing, defecation quantity and number of times all can increase, and the dud that enteral can be made easily to cause putrefaction bacteria to grow shortened in the enteral holdup time, played the effect preventing intestinal cancer.
Described apple vinegar is rich in pectin, vitamin, mineral and ferment, its acid ingredient can dredge vessel softening, killing pathogenic bacteria, strengthen immunity and the anti-virus ability of human body, improve digestive system, cleaning digestive tract, helps the toxin getting rid of joint, blood vessel and internal organs, endocrine regulation, has and obviously reduces blood fat and detoxifying health-care function.
Described ferment can help to decompose food, contribute to intestinal digesting and assimilating food, containing a large amount of dietary fiber, fruit acid and probiotics etc. in ferment, these materials can help to shorten the time of staying of food in intestinal, reduce the toxin that food rots to produce in intestinal, can effectively help intestinal " to have a bath ".
Described dietary fiber can be used as " intestinal street cleaner ", run into water can expand, or become clear gum material, easily by enteric bacterial fermentation and utilization in intestinal, produce the organic acid having and stimulate enterokinesia, promote defecation effect, these organic acid directly can be utilized by large intestine surface mucous cell simultaneously, as energy source, the metabolism of protection of intestinal mucosal barrier cells can be promoted, therefore there is the effect promoting large gut health, can the garbage in intestinal be got rid of external in time, can not constipation be produced, decrease the various diseases that constipation causes.
Compared with prior art, the present invention has following characteristics:
1) recipe ingredient forms simple, on the basis of lactobacillus needed for supplementary intestinal, and be aided with isomerized lactose powder, promote the growth of probiotics bacillus bifidus in intestinal, make lactobacillus and bacillus bifidus balanced growth in intestinal, and suppress the growth of Putrefying bacteria and pathogen, and then active balance intestinal beneficial flora;
2) on the basis of lactobacillus, isomerized lactose powder, be combined apple vinegar, ferment, dietary fiber, play synergism, common promotion gastrointestinal motility, activation intestinal body cell, promote steatolysis, efficiently the toxin be detained in intestinal being excreted in time, providing body environment to ensure for improving human body intestinal canal flora;
3) preparation technology is simple, instant effect, and be suitable for crowd extensive, dosage is few, few side effects, good stability, long shelf-life, takes medicine convenient and is easy to carry about with one, with low cost, is applicable to large-scale production.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in detail.
Embodiment 1:
The present embodiment, for improving the biological preparation of human body intestinal canal flora, comprises following component and weight portion content: lactobacillus 62 parts, 48 parts, isomerized lactose powder, apple vinegar 32 parts, 40 parts, ferment and dietary fiber 24 parts.
Wherein, the viable count of lactobacillus is 1,000 hundred million/g; The effective ingredient of isomerized lactose powder is 99%.
Ferment within 72 hours, is prepared from by culture medium inoculated Lactobacillus plantarum, Bifidobacterium lactis, bacillus acidophilus's mixed culture fermentation, and the inoculum concentration of Lactobacillus plantarum is 40,000,000,000/gram, the inoculum concentration of Bifidobacterium lactis is 30,000,000,000/gram, the inoculum concentration of bacillus acidophilus is 40,000,000,000/gram, wherein, culture medium comprises following component and weight portion content: apple powder 30 parts, orange powder 30 parts, oatmeal 20 parts and Rhizoma amorphophalli powder 20 parts.
Dietary fiber by oligofructose, oligomeric isomaltose and oligomeric xylose in mass ratio for 2:1:1 mixes.
The present embodiment specifically comprises the following steps for the preparation method of the biological preparation improving human body intestinal canal flora:
(1) get the raw materials ready by following component and weight portion:
Lactobacillus 62 parts, 48 parts, isomerized lactose powder, apple vinegar 32 parts, 40 parts, ferment and dietary fiber 24 parts;
(2) by weight lactobacillus, apple vinegar and dietary fiber are fully uniformly mixed, then add isomerized lactose powder, ferment, continue to be uniformly mixed 45min, by sterilizing, i.e. obtained biological preparation.
The instructions of taking of the present embodiment gained biological preparation is: at 1-2 hour after meal every day took 500-600mg.
When carrying out clinical research, 86 examples are selected to suffer from the patient of constipation, age 18-65 year between, be divided into matched group at random according to symptom weight and take group, often group is 43 examples, take group and adopt this enforcement biological preparation tablet, matched group takes conventional bacillus bifidus live triple capsule, considers the principal element affecting observed result as far as possible, as age, sex, the course of disease etc., carry out harmony inspection, to guarantee, between examination group, there is comparability.
Therapeutic test the results are shown in Table 1.
Table 1 clinical trial result
| Group | Total number of persons | Effective/people | Effectively/people | Invalid/people | Total effective rate (%) |
| Take group | 43 | 24 | 17 | 2 | 95.35* |
| Matched group | 43 | 19 | 11 | 13 | 69.77 |
Recurrence result of the test is in table 2.
Table 2 recurs result of the test
| Group | Total number of persons | In 1 month/people | In 2 months/people |
| Take group | 43 | 3(6.98％)* | 5(11.63％)* |
| Matched group | 43 | 9(20.93％) | 13(30.23％) |
From table 1 result of the test, adopt the evident in efficacy of the present embodiment biological preparation treatment constipation, the effective percentage that patient takes can up to more than 95%, and can be obtained by recurrence test result analysis, 1 month relapse rate of the present embodiment biological preparation is about 7%, within 2 months, relapse rate is about 12%, is all starkly lower than matched group, this also illustrate the present embodiment biological preparation there is instant effect, be suitable for crowd extensively, the feature of few side effects and good stability.
Embodiment 2:
The present embodiment, for improving the biological preparation of human body intestinal canal flora, comprises following component and weight portion content: lactobacillus 68 parts, 50 parts, isomerized lactose powder, apple vinegar 50 parts, 50 parts, ferment and dietary fiber 30 parts.
Wherein, the viable count of lactobacillus is 50,000,000,000/g; The effective ingredient of isomerized lactose powder is 99%.
Ferment within 72 hours, is prepared from by culture medium inoculated Lactobacillus plantarum, Bifidobacterium lactis, bacillus acidophilus's mixed culture fermentation, and the inoculum concentration of Lactobacillus plantarum is 15,000,000,000/gram, the inoculum concentration of Bifidobacterium lactis is 40,000,000,000/gram, the inoculum concentration of bacillus acidophilus is 15,000,000,000/gram, wherein, culture medium comprises following component and weight portion content: apple powder 20 parts, orange powder 20 parts, oatmeal 30 parts and Rhizoma amorphophalli powder 30 parts.
Dietary fiber by oligofructose, oligomeric isomaltose and oligomeric lactose in mass ratio for 2:1:2 mixes.
The present embodiment specifically comprises the following steps for the preparation method of the biological preparation improving human body intestinal canal flora:
(1) get the raw materials ready by following component and weight portion:
Lactobacillus 68 parts, 50 parts, isomerized lactose powder, apple vinegar 50 parts, 50 parts, ferment and dietary fiber 30 parts;
(2) by weight lactobacillus, apple vinegar and dietary fiber are fully uniformly mixed, then add isomerized lactose powder, ferment, continue to be uniformly mixed 30min, by sterilizing, i.e. obtained biological preparation.
The instructions of taking of the present embodiment gained biological preparation is: at 1-2 hour after meal every day took 500-600mg.
Embodiment 3:
The present embodiment, for improving the biological preparation of human body intestinal canal flora, comprises following component and weight portion content: lactobacillus 45 parts, 30 parts, isomerized lactose powder, apple vinegar 20 parts, 30 parts, ferment and dietary fiber 10 parts.
Wherein, the viable count of lactobacillus is 80,000,000,000/g; The effective ingredient of isomerized lactose powder is 98%.
Ferment within 72 hours, is prepared from by culture medium inoculated Lactobacillus plantarum, Bifidobacterium lactis, bacillus acidophilus's mixed culture fermentation, the inoculum concentration of Lactobacillus plantarum is 20,000,000,000/gram, the inoculum concentration of Bifidobacterium lactis is 15,000,000,000/gram, the inoculum concentration of bacillus acidophilus is 35,000,000,000/gram, wherein, culture medium comprises following component and weight portion content: apple powder 25 parts, orange powder 28 parts, oatmeal 24 parts and Rhizoma amorphophalli powder 30 parts.
Dietary fiber by pectin and oligomeric isomaltose in mass ratio for 1:3 mixes.
The present embodiment specifically comprises the following steps for the preparation method of the biological preparation improving human body intestinal canal flora:
(1) get the raw materials ready by following component and weight portion:
Lactobacillus 45 parts, 30 parts, isomerized lactose powder, apple vinegar 20 parts, 30 parts, ferment and dietary fiber 10 parts;
(2) by weight lactobacillus, apple vinegar and dietary fiber are fully uniformly mixed, then add isomerized lactose powder, ferment, continue to be uniformly mixed 40min, by sterilizing, i.e. obtained biological preparation.
The instructions of taking of the present embodiment gained biological preparation is: at 1-2 hour after meal every day took 500-600mg.
Embodiment 4:
The present embodiment, for improving the biological preparation of human body intestinal canal flora, comprises following component and weight portion content: lactobacillus 56 parts, 32 parts, isomerized lactose powder, apple vinegar 24 parts, 43 parts, ferment and dietary fiber 16 parts.
Wherein, the viable count of lactobacillus is 60,000,000,000/g; The effective ingredient of isomerized lactose powder is 99%.
Ferment within 72 hours, is prepared from by culture medium inoculated Lactobacillus plantarum, Bifidobacterium lactis, bacillus acidophilus's mixed culture fermentation, the inoculum concentration of Lactobacillus plantarum is 32,000,000,000/gram, the inoculum concentration of Bifidobacterium lactis is 28,000,000,000/gram, the inoculum concentration of bacillus acidophilus is 30,000,000,000/gram, wherein, culture medium comprises following component and weight portion content: apple powder 21 parts, orange powder 23 parts, oatmeal 28 parts and Rhizoma amorphophalli powder 25 parts.
Dietary fiber is oligomeric isomaltose.
The present embodiment specifically comprises the following steps for the preparation method of the biological preparation improving human body intestinal canal flora:
(1) get the raw materials ready by following component and weight portion:
Lactobacillus 56 parts, 32 parts, isomerized lactose powder, apple vinegar 24 parts, 43 parts, ferment and dietary fiber 16 parts;
(2) by weight lactobacillus, apple vinegar and dietary fiber are fully uniformly mixed, then add isomerized lactose powder, ferment, continue to be uniformly mixed 35min, by sterilizing, i.e. obtained biological preparation.
The instructions of taking of the present embodiment gained biological preparation is: at 1-2 hour after meal every day took 500-600mg.
Embodiment 5:
The present embodiment, for improving the biological preparation of human body intestinal canal flora, comprises following component and weight portion content: lactobacillus 62 parts, 46 parts, isomerized lactose powder, apple vinegar 42 parts, 38 parts, ferment and dietary fiber 21 parts.
Wherein, the viable count of lactobacillus is 1,000 hundred million/g; The effective ingredient of isomerized lactose powder is 99%.
Ferment within 72 hours, is prepared from by culture medium inoculated Lactobacillus plantarum, Bifidobacterium lactis, bacillus acidophilus's mixed culture fermentation, the inoculum concentration of Lactobacillus plantarum is 15,000,000,000/gram, the inoculum concentration of Bifidobacterium lactis is 15,000,000,000/gram, the inoculum concentration of bacillus acidophilus is 15,000,000,000/gram, wherein, culture medium comprises following component and weight portion content: apple powder 20 parts, orange powder 29 parts, oatmeal 30 parts and Rhizoma amorphophalli powder 25 parts.
Dietary fiber is oligomeric xylose.
The present embodiment specifically comprises the following steps for the preparation method of the biological preparation improving human body intestinal canal flora:
(1) get the raw materials ready by following component and weight portion:
Lactobacillus 62 parts, 46 parts, isomerized lactose powder, apple vinegar 42 parts, 38 parts, ferment and dietary fiber 21 parts;
(2) by weight lactobacillus, apple vinegar and dietary fiber are fully uniformly mixed, then add isomerized lactose powder, ferment, continue to be uniformly mixed 40min, by sterilizing, i.e. obtained biological preparation.
The instructions of taking of the present embodiment gained biological preparation is: at 1-2 hour after meal every day took 500-600mg.
Embodiment 6:
The present embodiment, for improving the biological preparation of human body intestinal canal flora, comprises following component and weight portion content: lactobacillus 64 parts, 42 parts, isomerized lactose powder, apple vinegar 37 parts, 33 parts, ferment and dietary fiber 26 parts.
Wherein, the viable count of lactobacillus is 90,000,000,000/g; The effective ingredient of isomerized lactose powder is 98%.
Ferment within 72 hours, is prepared from by culture medium inoculated Lactobacillus plantarum, Bifidobacterium lactis, bacillus acidophilus's mixed culture fermentation, the inoculum concentration of Lactobacillus plantarum is 40,000,000,000/gram, the inoculum concentration of Bifidobacterium lactis is 40,000,000,000/gram, the inoculum concentration of bacillus acidophilus is 20,000,000,000/gram, wherein, culture medium comprises following component and weight portion content: apple powder 26 parts, orange powder 23 parts, oatmeal 22 parts and Rhizoma amorphophalli powder 29 parts.
Dietary fiber is oligofructose.
The present embodiment specifically comprises the following steps for the preparation method of the biological preparation improving human body intestinal canal flora:
(1) get the raw materials ready by following component and weight portion:
Lactobacillus 64 parts, 42 parts, isomerized lactose powder, apple vinegar 37 parts, 33 parts, ferment and dietary fiber 26 parts;
(2) by weight lactobacillus, apple vinegar and dietary fiber are fully uniformly mixed, then add isomerized lactose powder, ferment, continue to be uniformly mixed 45min, by sterilizing, i.e. obtained biological preparation.
The instructions of taking of the present embodiment gained biological preparation is: at 1-2 hour after meal every day took 500-600mg.
Embodiment 7:
The present embodiment, for improving the biological preparation of human body intestinal canal flora, comprises following component and weight portion content: lactobacillus 52 parts, 38 parts, isomerized lactose powder, apple vinegar 23 parts, 47 parts, ferment and dietary fiber 18 parts.
Wherein, the viable count of lactobacillus is 90,000,000,000/g; The effective ingredient of isomerized lactose powder is 98%.
Ferment within 72 hours, is prepared from by culture medium inoculated Lactobacillus plantarum, Bifidobacterium lactis, bacillus acidophilus's mixed culture fermentation, the inoculum concentration of Lactobacillus plantarum is 24,000,000,000/gram, the inoculum concentration of Bifidobacterium lactis is 30,000,000,000/gram, the inoculum concentration of bacillus acidophilus is 25,000,000,000/gram, wherein, culture medium comprises following component and weight portion content: apple powder 27 parts, orange powder 30 parts, oatmeal 26 parts and Rhizoma amorphophalli powder 24 parts.
Dietary fiber is oligomeric lactose.
The present embodiment specifically comprises the following steps for the preparation method of the biological preparation improving human body intestinal canal flora:
(1) get the raw materials ready by following component and weight portion:
Lactobacillus 52 parts, 38 parts, isomerized lactose powder, apple vinegar 23 parts, 47 parts, ferment and dietary fiber 18 parts;
(2) by weight lactobacillus, apple vinegar and dietary fiber are fully uniformly mixed, then add isomerized lactose powder, ferment, continue to be uniformly mixed 35min, by sterilizing, i.e. obtained biological preparation.
The instructions of taking of the present embodiment gained biological preparation is: at 1-2 hour after meal every day took 500-600mg.
Claims (8)
1. one kind for improving the biological preparation of human body intestinal canal flora, it is characterized in that, this biological preparation comprises following component and weight portion content: lactobacillus 45-68 part, isomerized lactose powder 30-50 part, apple vinegar 20-50 part, ferment 30-50 part and dietary fiber 10-30 part.
2. a kind of biological preparation for improving human body intestinal canal flora according to claim 1, is characterized in that, the viable count of described lactobacillus is 500-1000 hundred million/g.
3. a kind of biological preparation for improving human body intestinal canal flora according to claim 1, is characterized in that, effective ingredient >=97% of described isomerized lactose powder.
4. a kind of biological preparation for improving human body intestinal canal flora according to claim 1, it is characterized in that, described ferment within 72 hours, is prepared from by culture medium inoculated Lactobacillus plantarum, Bifidobacterium lactis, bacillus acidophilus's mixed culture fermentation, wherein, described culture medium comprises following component and weight portion content: apple powder 20-30 part, orange powder 20-30 part, oatmeal 20-30 part and Rhizoma amorphophalli powder 20-30 part.
5. a kind of biological preparation for improving human body intestinal canal flora according to claim 1, is characterized in that, described dietary fiber is water soluble dietary fiber.
6. a kind of biological preparation for improving human body intestinal canal flora according to claim 5, is characterized in that, described water soluble dietary fiber comprise in pectin, oligofructose, oligomeric isomaltose, oligomeric lactose or oligomeric xylose one or more.
7. a kind of biological preparation for improving human body intestinal canal flora according to claim 1, is characterized in that, the instructions of taking of described biological preparation is: at 1-2 hour after meal every day took 500-600mg.
8. as claimed in claim 1 for improving a preparation method for the biological preparation of human body intestinal canal flora, it is characterized in that, the method specifically comprises the following steps:
(1) get the raw materials ready by following component and weight portion:
Lactobacillus 45-68 part, isomerized lactose powder 30-50 part, apple vinegar 20-50 part, ferment 30-50 part and dietary fiber 10-30 part;
(2) by weight lactobacillus, apple vinegar and dietary fiber are fully uniformly mixed, then add isomerized lactose powder, ferment, continue to be uniformly mixed 30-45min, by sterilizing, i.e. obtained biological preparation.
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