CN105535578A - Composition paste agent for mitigating side effects of chemotherapy for tumor patient - Google Patents

Composition paste agent for mitigating side effects of chemotherapy for tumor patient Download PDF

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CN105535578A
CN105535578A CN201510947575.9A CN201510947575A CN105535578A CN 105535578 A CN105535578 A CN 105535578A CN 201510947575 A CN201510947575 A CN 201510947575A CN 105535578 A CN105535578 A CN 105535578A
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parts
rhizoma
radix
chemotherapy
chinese medicine
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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Abstract

The invention discloses a composition paste agent for mitigating side effects of chemotherapy for tumor patients. The composition paste agent is prepared from the following raw materials by weight: 6-12 parts of bambusae caulis im taeniam, 6-15 parts of bighead atractylodes rhizome (stir-fried with bran), 4-8 parts of goldthread, 6-12 parts of the root of red-rooted salvia, 5-12 parts of common bletilla tuber, 3-6 parts of rhubarb, 5-11 parts of Equisetum hiemale, 6-12 parts of Mangnolia officinalis, 3-6 parts of indigo, 4-8 parts of rhizoma cyperi (vinegar), 6-18 parts of myrrh, 6-12 parts of costus root, 9-15 parts of chorion ovi, 4-9 parts of Carpesium abrotanoides L., and 4-12 parts of Rhizome Pinelliae Preparata. The invention has the excellent effect that the composition paste agent is in full accordance with the principles of traditional Chinese medicine and physical and psychological characteristics of cancer patients, and can effectively reduce the side effects of chemotherapy; and the selected materials are all traditional Chinese medicines without any side effects.

Description

The Traditional Chinese medicine composition paste of ameliorate tumor chemotherapy of patients side reaction
Divisional application, original applying number 2014101448693, applying date 2014.04.12, the Chinese medicine composition of title ameliorate tumor chemotherapy of patients side reaction and method for making.
Technical field
The invention discloses a kind of Chinese medicine composition, the Chinese medicine composition of particularly a kind of ameliorate tumor chemotherapy of patients side reaction and method for making.The invention belongs to traditional Chinese medicine field.
Background technology
Malignant tumor is a large disease of serious threat human health and life, and chemotherapy is one of method for the treatment of malignant tumor.Chemotherapy, i.e. chemotherapy, be utilize chemicals kill tumor cell, inhibition tumor cell growth and breeding and promote a kind of therapeutic modality of differentiation of tumor cell, it is that a kind of systemic treatment means all have therapeutical effect to primary tumor, metastasis and subclinical metastasis.The continuing to bring out of cancer therapy drug, the progress of science and technology and the reasonable application of Combination chemotherapy in recent years makes the chemotherapeutic efficacy of tumor have to significantly improve, the scope that but chemotherapy belongs to " sending an expedition against ", often occur attacking the positive situation of evil wound, chemotherapeutic treatment tumor is while killing tumor cell, also normal cell and immunity (opposing) cell are together killed, so chemotherapy is the Therapeutic Method of a kind of " destruction of all people good and bad alike ".The main side reaction of chemotherapy is bone marrow depression, digestive tract reaction and neurotoxin reaction etc., particularly Advanced cancers or weakly patient, blindly uses chemotherapy, the state of an illness not only can be caused to worsen rapidly, more can accelerate the death of patient.
The side reaction main manifestations of chemotherapy is:
1. nervous system toxicity: mainly refer to that chemotherapeutics produces detrimental effect to peripheral terminals nerve, patient can occur acroanesthesia, and acra is insensitive.
2. Nausea and vomiting and inappetence: after accepting chemotherapy, because drug effect can have power along with medicine concentration level in vivo, so patient there will be degradation symptom under lassitude, nausea and vomiting and appetite after accepting chemotherapy.
3. bone marrow depression: great majority all can cause bone marrow depression to the effective chemotherapeutics of malignant tumor patient, shows as leukocyte and platelet declines, notably degradation under erythrocyte, hematochrome.
4. suffer from diarrhoea: for chemotherapy patient diarrhoea be a common problem.Diarrhoea can be very serious, even threat to life, but diarrhoea is also the common side reaction of chemotherapy.
5. tired: malignant tumor patient is at chemotherapeutic period, because the time is longer, so patient just needs a large amount of some energy consuming human body, the pressure that disease is brought, comes and goes treatment every day and radiation all can cause fatigue to Normocellular impact.
6. alopecia: hair follicle is being subject to the impact of chemotherapeutic agent, after alopecia usually can occur in and accept chemotherapy for several times, it is severe than usual that you can think that hair falls, and after adding up repeatedly, hair is comparatively lax, easily sees scalp.
Malignant tumor belongs to that the traditional Chinese medical science " is amassed ", the category of " asthenia ", there is the performance of vital QI being weakened and pathogen being violent.And due to being continuous of the course of disease, the phenomenon of " the kidney usually involved in chronic disease " can be caused.After accepting chemotherapy, disease that it is weakened body resistance is more obvious, and hinder and then feel sick indigestion and loss of appetite in stomach, hinder in kidney then dizziness and tinnitus, dedentition loss of hairs, soreness of waist foot is soft, hinders in the heart then shortness of breath and palpitation.Therefore, the side reaction of ameliorate tumor chemotherapy of patients has very important medical value.
Publication number is CN1357354A(application number 01114965.5) Chinese patent literature disclose a kind of by name " medicine for the treatment of concurrent chemoradiotherapy of malignant tumor side reaction and preparation method thereof ", it is made up of Radix Codonopsis, the Radix Astragali, Poria, the Rhizoma Atractylodis Macrocephalae, Fructus Ligustri Lucidi, Fructus Lycii, burnt short, bristly hair or beard, Radix Glycyrrhizae.Its formula preparation method is complicated, is not suitable for individual's operation.Application publication number is CN102327390A(application number 201110314905.2) Chinese patent literature disclose a kind of by name " a kind of prevent and treat the Chinese prescription of chemotherapy toxic side effect and the preparation method of pill thereof ", this Chinese prescription is made up of according to certain weight proportion Colla Corii Asini, Radix Ginseng, Cortex Cinnamomi, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Poria, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Semen Cuscutae, Fructus Lycii, Radix Cyathulae, Pericarpium Citri Reticulatae, Ganoderma, Herba Cistanches, Cornu Cervi Pantotrichum, Moschus, Stalactitum, Radix Morindae Officinalis, Radix Aconiti Lateralis Preparata, Stichopus japonicus, Radix Glycyrrhizae, Colla cornus cervi, yellow wine.Its formula medical material is numerous, and indivedual price of medicinal material is higher, adds the financial burden of patient.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of prepare simple, be easy to carry, the Chinese medicine composition of the ameliorate tumor chemotherapy of patients side reaction of taking convenience and method for making.This Chinese medicine composition is developed according to the body and mind feature of tumour patient completely, determined curative effect and without any side effects.
Technical scheme of the present invention is:
The Chinese medicine composition of ameliorate tumor chemotherapy of patients side reaction, takes off the primary raw material stating weight proportion and is prepared from: QINGZHU eats 6-12 part, the Rhizoma Atractylodis Macrocephalae (parched with bran) 6-15 part, Rhizoma Coptidis 4-8 part, Radix Salviae Miltiorrhizae 6-12 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-12 part, Radix Et Rhizoma Rhei 3-6 part, Herba Equiseti Hiemalis 5-11 part, Cortex Magnoliae Officinalis 6-12 part, Indigo Naturalis 3-6 part, Rhizoma Cyperi (vinegar) 4-8 part, Myrrha 6-18 part, Radix Aucklandiae (Radix Vladimiriae) 6-12 part, Membrana Follicularis ovi 9-15 part, Radix Carpesii 4-9 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 4-12 part.
The Chinese medicine composition of ameliorate tumor chemotherapy of patients side reaction, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: QINGZHU eats 8-10 part, the Rhizoma Atractylodis Macrocephalae (parched with bran) 8-12 part, Rhizoma Coptidis 5-7 part, Radix Salviae Miltiorrhizae 8-10 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 7-10 part, Radix Et Rhizoma Rhei 3-5 part, Herba Equiseti Hiemalis 7-9 part, Cortex Magnoliae Officinalis 8-10 part, Indigo Naturalis 4-6 part, Rhizoma Cyperi (vinegar) 5-7 part, Myrrha 10-14 part, Radix Aucklandiae (Radix Vladimiriae) 8-10 part, Membrana Follicularis ovi 11-13 part, Radix Carpesii 5-7 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 7-9 part.
The Chinese medicine composition of ameliorate tumor chemotherapy of patients side reaction, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: QINGZHU eats 9 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, Rhizoma Coptidis 6 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Radix Et Rhizoma Rhei 4 parts, Herba Equiseti Hiemalis 8 parts, Cortex Magnoliae Officinalis 9 parts, Indigo Naturalis 5 parts, Rhizoma Cyperi (vinegar) 6 parts, Myrrha 12 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Membrana Follicularis ovi 12 parts, Radix Carpesii 6 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.
Present invention also offers and above-mentioned Chinese medicine composition is made pharmaceutically acceptable powder, water preparation, unguentum, granule, tablet or capsule.
The preparation method of described powder is:
(1) Radix Et Rhizoma Rhei, Indigo Naturalis are ground into fine powder respectively, cross 60-120 mesh sieve and (preferably, cross 85-115 mesh sieve; Be more preferably, cross 105 mesh sieves);
(2) QINGZHU is eaten, the Rhizoma Atractylodis Macrocephalae (parched with bran), Rhizoma Coptidis, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Equiseti Hiemalis, Cortex Magnoliae Officinalis, Rhizoma Cyperi (vinegar), Myrrha, Radix Aucklandiae (Radix Vladimiriae), Membrana Follicularis ovi, Radix Carpesii and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) co-grinding cross 85-135 mesh sieve (preferred, cross 100-120 mesh sieve; Be more preferably, cross 110 mesh sieves);
(3) step (1) and (2) gained are mixed.
The preparation method of described water preparation is:
(1) Radix Et Rhizoma Rhei, Indigo Naturalis are ground into fine powder respectively, cross 60-120 mesh sieve and (preferably, cross 85-115 mesh sieve; Be more preferably, cross 105 mesh sieves);
(2) QINGZHU is eaten, the Rhizoma Atractylodis Macrocephalae (parched with bran), Rhizoma Coptidis, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Equiseti Hiemalis, Cortex Magnoliae Officinalis, Rhizoma Cyperi (vinegar), Myrrha, Radix Aucklandiae (Radix Vladimiriae), Membrana Follicularis ovi, Radix Carpesii and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) be placed in marmite, adding water, (water consumption is that doubly (preferred, 3-4 doubly for the 2.5-4.5 of crude drug gross weight; Be more preferably, 3.5 times)) decoct 2 times, 1.2-2.4 hour first time (preferred, 1.5-2.0 hour; Be more preferably, 1.8 hours), second time 0.8-1.2 hour (preferred 0.9-1.1 hour; Be more preferably, 1.0 hours), filtrate merges, and lets cool;
(3) Radix Et Rhizoma Rhei after step (1) being pulverized and Indigo Naturalis add step (2) gained medicinal liquid, sterile packaged.
The preparation method of described unguentum is:
(1) Radix Et Rhizoma Rhei, Indigo Naturalis are ground into fine powder respectively, cross 60-120 mesh sieve (preferred, to cross 85-115 mesh sieve, be more preferably, cross 105 mesh sieves);
(2) QINGZHU is eaten, the Rhizoma Atractylodis Macrocephalae (parched with bran), Rhizoma Coptidis, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Equiseti Hiemalis, Cortex Magnoliae Officinalis, Rhizoma Cyperi (vinegar), Myrrha, Radix Aucklandiae (Radix Vladimiriae), Membrana Follicularis ovi, Radix Carpesii and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) be placed in marmite, adding water, (water consumption is that doubly (preferred, 3-4 doubly for the 2.5-4.5 of crude drug gross weight; Be more preferably, 3.5 times)) decoct 2 times, 1.2-2.4 hour first time (preferred, 1.5-2.0 hour; Be more preferably, 1.8 hours), second time 0.8-1.2 hour (preferred 0.9-1.1 hour; Be more preferably, 1.0 hours), filtrate merges, and filters, concentrated that relative density is 1.36-1.38(48 DEG C) clear paste;
(3) Radix Et Rhizoma Rhei after step (1) being pulverized and Indigo Naturalis add step (2) gained clear paste, sterile packaged.
The preparation method of described granule is:
(1) Radix Et Rhizoma Rhei, Indigo Naturalis are ground into fine powder respectively, cross 60-120 mesh sieve and (preferably, cross 85-115 mesh sieve; Be more preferably, cross 105 mesh sieves);
(2) QINGZHU is eaten, the Rhizoma Atractylodis Macrocephalae (parched with bran), Rhizoma Coptidis, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Equiseti Hiemalis, Cortex Magnoliae Officinalis, Rhizoma Cyperi (vinegar), Myrrha, Radix Aucklandiae (Radix Vladimiriae), Membrana Follicularis ovi, Radix Carpesii and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) be placed in marmite, adding water, (water consumption is that doubly (preferred, 3-4 doubly for the 2.5-4.5 of crude drug gross weight; Be more preferably, 3.5 times)) decoct 2 times, 1.2-2.4 hour first time (preferred, 1.5-2.0 hour; Be more preferably, 1.8 hours), second time 0.8-1.2 hour (preferred 0.9-1.1 hour; Be more preferably, 1.0 hours), filtrate merges, and filters, concentrated that relative density is 1.36-1.38(48 DEG C) clear paste;
(3) qinghuo reagent 0.8-1.2 part (preferably, 0.9-1.1 part; Be more preferably, 1.0 parts), and sucrose 1.5-3.5 part (preferred, 2-3 part; 2.5 parts that are more preferably), and dextrin 0.8-1.2 part (preferred, 0.9-1.1 part; Be more preferably, 1.0 parts), add step (1) gained Radix Et Rhizoma Rhei and Indigo Naturalis fine powder after mixing, mixing, makes granule, dry, obtains granule.
The preparation method of described tablet is: by claim 5 gained Chinese medicine powder according to 0.3-0.5g/ sheet (preferably, 0.35-0.45g/ sheet; Be more preferably, 0.4g/ sheet) metering, the tablet dosage form of circle or other shapes is pressed into according to the preparation for processing of tablet.
The preparation method of described capsule is: by claim 5 gained Chinese medicine powder according to 0.4-0.6g/ grain (preferably, 0.45-0.55g/ grain; Be more preferably, 0.5g/ grain) metering, be processed into capsule shape dosage form according to the preparation for processing of capsule.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
QINGZHU is eaten: nature and flavor: sweet in the mouth, is slightly cold.Gui Jing: lung, stomach, gallbladder meridian.Effect: removing heat-phlegm, relieves restlessness and prevents vomiting.Cure mainly: phlegm-heat cough, expectorant held under the arm by gallbladder fire, and dysphoria with smothery sensation is vomitted, and eye is lost in palpitation with fear, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement.
The Rhizoma Atractylodis Macrocephalae (parched with bran): nature and flavor: bitter in the mouth, sweet, temperature.Gui Jing: return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.Cure mainly: deficiency-weakness of spleen-QI weak, lack of appetite abdominal distention, constipation of having loose bowels, the dysuria of fluid-retention stagnating in the interior, edema, dizziness due to fluid-retention, cold-damp numbness, general pain, spontaneous sweating due to deficiency of QI, frequent fetal movement.
Rhizoma Coptidis: nature and flavor: bitter in the mouth, cold.Gui Jing: GUIXIN, liver, stomach, large intestine channel.Effect: clearing away heat-fire, dampness, removing toxic substances.Cure mainly: calentura heresy enters the high heat of heart channel, irritated, delirium or the absurd row of intenseness of heat forcing blood tell nosebleed, damp and hot Bears painful abdominal mass is had loose bowels, dysentery, the vexed insomnia of hyperactivity of heart-fire, gastropyretic vomiting, rapid digestion of food and polyorexia, liver-fire conjunctival congestion and swelling pain, and pathopyretic ulcer, furunculosis septicemia, gingival swelling and pain, aphtha of the mouth and tongue, Ting ear, hemorrhoidal bleeding, eczema, scalds.
Radix Salviae Miltiorrhizae: nature and flavor: bitter in the mouth, is slightly cold.Gui Jing: GUIXIN, pericardium, Liver Channel.Effect: blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving, relieving restlessness is calmed the nerves, removing heat from blood eliminating carbuncle.Cure mainly: menoxenia, dysmenorrhea, amenorrhea, stomachache of being retarded by silt puerperal, trusted subordinate's pain, lumps in the chest and abdomen, pyretic arthralgia swells and ache, traumatic injury, and heat enters nutrient blood, dysphoria, vexed insomnia, carbuncle pyogenic infections from tumour or sore.
Pseudobulbus Bletillae (Rhizoma Bletillae): nature and flavor: bitter in the mouth, sweet, puckery, is slightly cold.Gui Jing: return lung, kidney channel.Effect: astringing to arrest bleeding, detumescence and promoting granulation.Cure mainly: spitting of blood, spit blood, epistaxis, has blood in stool, traumatic hemorrhage, carbuncle pyogenic infections from tumour or sore, scalds and burns, rhagadia manus et pedis, anal fissure.
Radix Et Rhizoma Rhei: nature and flavor: bitter in the mouth, cold.Gui Jing: stomach, large intestine, liver, spleen channel.Effect: attack stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, removing toxic substances.Cure mainly: solid cubic content constipation, the accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery, jaundice, gonorrhea, edema abdominal distention, dysuria; Conjunctival congestion, laryngopharynx swelling and pain, aphtha of the mouth and tongue, gastropyretic vomiting, spits blood, spitting of blood, and epistaxis, has blood in stool, hematuria; Blood-retention, amenorrhea, stomachache of being retarded by silt puerperal ， lumps in the chest and abdomen, traumatic injury, pyretic toxicity carbuncle and ulcer, erysipelas, scalds.
Herba Equiseti Hiemalis: nature and flavor: sweet in the mouth, micro-hardship, flat.Gui Jing: return lung, liver, gallbladder meridian.Effect: wind-dispelling heat-dissipating, improving acuity of vision and removing nebula, hemostasis.Cure mainly: wind heat conjunctival congestion, the raw nebula of order, epiphora induced by wind, discharging fresh blood stool, hemorrhoidal bleeding, dysentery, married woman's metrorrhagia, proctoptosis.
Cortex Magnoliae Officinalis: nature and flavor: bitter in the mouth, pungent, warm in nature.Gui Jing: return spleen, stomach, large intestine channel.Effect: circulation of qi promoting removing dampness, warming middle-JIAO to relieve pain, lowering the adverse QI to relieve asthma.Cure mainly: stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant stops up QI rising in reverse order; Fullness in the chest is breathed with cough.
Indigo Naturalis: nature and flavor: salty in the mouth, cold.Gui Jing: return liver, lung, stomach warp.Effect: heat clearing away, removing heat from blood, removing toxic substances.Cure mainly: warm malicious macule, spit blood, epistaxis, spitting of blood, pediatric epilepsy scared, liver-fire invading the lung is coughed, laryngopharynx swelling and pain, erysipelas, mumps, and skin ulcer swells, snake bite and insect sting.
Rhizoma Cyperi (vinegar): nature and flavor: acrid in the mouth, sweet, micro-hardship, flat.Gui Jing: return liver, tri-jiao channel.Effect: resolving depression of regulating the flow of vital energy, regulating menstruation, antiabortive.Cure mainly: distending pain over the hypochondrium, distending pain of the breast, hernia pain, menoxenia, gastral cavity abdomen feeling of fullness pain, belch acid regurgitation, vomiting and nausea, abdominal pain during menstruation, bleeding not during menses, frequent fetal movement.
Myrrha: nature and flavor: bitter in the mouth, pungent, flat.Gui Jing: return spleen, the heart, Liver Channel.Effect: blood stasis dispelling, detumescence, analgesic therapy.Cure mainly: breast is suffered from abdominal pain, and dysmenorrhea, amenorrhea ， mass in the abdomen, beats and swell and ache, carbuncle skin infection, conjunctival congestion and swelling pain.
Radix Aucklandiae (Radix Vladimiriae): nature and flavor: acrid in the mouth, hardship, temperature.Gui Jing: return lung, liver, spleen channel.Effect: promoting the circulation of QI to relieve pain, warming middle-JIAO for easing the stomach.Cure mainly: chest and abdomen swelling and pain, vomiting, has loose bowels, dysentery tenesmus.
Membrana Follicularis ovi: nature and flavor: sweet in the mouth is light, flat.Gui Jing: return lung meridian.Effect: nourishing YIN and clearing away lung-heat, sore, removing nebula, synthetism.Cure mainly: chronic cough is breathed heavily for a long time, pharyngalgia aphonia, ulcer being unable to heal, the raw cataracta of order, the vertigo, trauma fracture.
Radix Carpesii: base is former: be the herb of Compositae Carpesium plant Radix Carpesii.Nature and flavor: taste bitter, acrid, cold.Gui Jing: return liver, lung meridian.Effect: removing heat-phlegm, removing toxic substances parasite killing, removing blood stasis with potent drugs stops blooding.Cure mainly: tonsillitis sore throat, anxious chronic infantile convulsion, toothache, furuncle swells and ache, hemorrhoid complicated by anal fistula, itchy skin eruption, venom, malnutrition due to parasitic infestation, abdominal mass due to blood stasis, spits blood, epistaxis, stranguria with blood, wound hemorrhage
Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens): nature and flavor: acrid in the mouth, temperature.Gui Jing: return spleen, stomach, lung meridian.Effect: stopping nausea and vomiting by lowering the adverse flow of QI.Cure mainly: vomiting regurgitation, breast gastral cavity painful abdominal mass is vexed, globus hystericus.
Chinese medicine composition of the present invention, based on traditional Chinese medical herbal treatment chemotherapy side effect principle, is make on the basis that have studied lot of documents, pharmacology work and clinical trial.This Chinese medicine composition according to the body and mind feature of Chinese medicine principle and malignant tumor patient, has good therapeutic effect to the side reaction that chemotherapy causes completely.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The Chinese medicine composition of embodiment 1 ameliorate tumor chemotherapy of patients side reaction, takes off the primary raw material stating weight proportion and is prepared from (every part of 10g): QINGZHU eats 9 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, Rhizoma Coptidis 6 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Radix Et Rhizoma Rhei 4 parts, Herba Equiseti Hiemalis 8 parts, Cortex Magnoliae Officinalis 9 parts, Indigo Naturalis 5 parts, Rhizoma Cyperi (vinegar) 6 parts, Myrrha 12 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Membrana Follicularis ovi 12 parts, Radix Carpesii 6 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.
The preparation method of the Chinese medicine powder of above-mentioned ameliorate tumor chemotherapy of patients side reaction is:
(1) Radix Et Rhizoma Rhei, Indigo Naturalis are ground into fine powder respectively, cross 105 mesh sieves;
(2) QINGZHU is eaten, the Rhizoma Atractylodis Macrocephalae (parched with bran), Rhizoma Coptidis, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Equiseti Hiemalis, Cortex Magnoliae Officinalis, Rhizoma Cyperi (vinegar), Myrrha, Radix Aucklandiae (Radix Vladimiriae), Membrana Follicularis ovi, Radix Carpesii and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) co-grinding cross 110 mesh sieves;
(3) step (1) and (2) gained are mixed.
Powder instructions of taking of the present invention: powder is divided 5g/ bag, adopts every day 2-3 time, each one bag, with warm boiled water, and 7 days courses for the treatment of.
Model case one Ke XX, age: 51 years old, sex: man.Within 2008, suffer from Esophageal Middle Segment malignant tumor, accept chemotherapy in hospital, after chemotherapy, occur the symptoms such as acroanesthesia, nausea and vomiting, inappetence, health be tired.Take the Chinese medicine powder of this enforcement gained ameliorate tumor chemotherapy of patients side reaction, adopt every day 3 times, each one bag, with warm boiled water, 7 days courses for the treatment of.Take 15 days, patient's appetite strengthens to some extent, and malaise symptoms alleviates; Take 1 month, malaise symptoms is clearly better, and muscle power strengthens; Continue to take 2 months, patient's readme malaise symptoms disappears.
The Chinese medicine composition of embodiment 2 ameliorate tumor chemotherapy of patients side reaction, takes off the primary raw material stating weight proportion and is prepared from (every part of 20g): QINGZHU eats 9 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, Rhizoma Coptidis 6 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Radix Et Rhizoma Rhei 4 parts, Herba Equiseti Hiemalis 8 parts, Cortex Magnoliae Officinalis 9 parts, Indigo Naturalis 5 parts, Rhizoma Cyperi (vinegar) 6 parts, Myrrha 12 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Membrana Follicularis ovi 12 parts, Radix Carpesii 6 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.
The preparation method of the Traditional Chinese medicine composition paste of above-mentioned ameliorate tumor chemotherapy of patients side reaction is:
(1) Radix Et Rhizoma Rhei, Indigo Naturalis are ground into fine powder respectively, cross 105 mesh sieves;
(2) QINGZHU is eaten, the Rhizoma Atractylodis Macrocephalae (parched with bran), Rhizoma Coptidis, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Equiseti Hiemalis, Cortex Magnoliae Officinalis, Rhizoma Cyperi (vinegar), Myrrha, Radix Aucklandiae (Radix Vladimiriae), Membrana Follicularis ovi, Radix Carpesii and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) be placed in marmite, add water (water consumption is 3.5 times of crude drug gross weight) decoction 2 times, 1.8 hours first times, second time 1.0 hours, filtrate merges, filter, concentrated that relative density is 1.36-1.38(48 DEG C) clear paste;
(3) Radix Et Rhizoma Rhei after step (1) being pulverized and Indigo Naturalis add step (2) gained clear paste, sterile packaged.
Unguentum instructions of taking of the present invention: unguentum adopts every day 2 times, each 6-8g, takes according to the ratio bath of 1:10,7 days courses for the treatment of.
The old XX of model case two, age: 56 years old, sex: female.The right Rupture of Hepatocellular Carcinoma of constitutional in 2007, emergency case is cut open the belly, excision 7 × 8cm cancer block, and treat residual cancer by the method for chemotherapy afterwards, patient's readme chemotherapy can cause some side reactions, mainly contains: tired, hypoimmunity, inappetence, lethargy, drowsiness etc.Take the Traditional Chinese medicine composition paste of the present embodiment gained ameliorate tumor chemotherapy of patients side reaction, adopt every day 2 times, each 8g, take according to the ratio bath of 1:10,7 days courses for the treatment of.Take 10 days, patient mental's state takes a turn for the better, and drowsiness situation alleviates; Take 1 month, appetite strengthens to some extent, and malaise symptoms fades away; Continue to take 2 months, do not occur any discomfort when patient takes, the symptom that feels uneasy disappears completely.
The Chinese medicine composition of embodiment 3 ameliorate tumor chemotherapy of patients side reaction, takes off the primary raw material stating weight proportion and is prepared from (every part of 30g): QINGZHU eats 9 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, Rhizoma Coptidis 6 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Radix Et Rhizoma Rhei 4 parts, Herba Equiseti Hiemalis 8 parts, Cortex Magnoliae Officinalis 9 parts, Indigo Naturalis 5 parts, Rhizoma Cyperi (vinegar) 6 parts, Myrrha 12 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Membrana Follicularis ovi 12 parts, Radix Carpesii 6 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.
The preparation method of the Chinese medicinal composition granules of above-mentioned ameliorate tumor chemotherapy of patients side reaction is:
(1) Radix Et Rhizoma Rhei, Indigo Naturalis are ground into fine powder respectively, cross 105 mesh sieves;
(2) QINGZHU is eaten, the Rhizoma Atractylodis Macrocephalae (parched with bran), Rhizoma Coptidis, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Equiseti Hiemalis, Cortex Magnoliae Officinalis, Rhizoma Cyperi (vinegar), Myrrha, Radix Aucklandiae (Radix Vladimiriae), Membrana Follicularis ovi, Radix Carpesii and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) be placed in marmite, add water (water consumption is 3.5 times of crude drug gross weight) decoction 2 times, 1.8 hours first times, second time 1.0 hours, filtrate merges, filter, concentrated that relative density is 1.36-1.38(48 DEG C) clear paste;
(3) qinghuo reagent 1.0 parts, sucrose 2.5 parts, 1.0 parts, dextrin, adds step (1) gained Radix Et Rhizoma Rhei and Indigo Naturalis fine powder after mixing, mixing, makes granule, dry, obtains granule.
Granule instructions of taking of the present invention: granule is divided 8g/ bag, every day 2-3 time, each one bag, with warm boiled water, 7 days courses for the treatment of.
Model case three Xiao XX, age: 69 years old, sex: female.At examination in hospital, in June, 2009 finds that malignant tumor appears in liver, because tumor is comparatively large, should not perform the operation, therefore do chemotherapy to alleviate slight illness, but some side reactions appear in chemotherapy: acra is insensitive, nausea and vomiting, diarrhoea, health are weak, alopecia etc.Take the Chinese medicinal composition granules of the present embodiment gained ameliorate tumor chemotherapy of patients side reaction, adopt every day 3 times, each one bag, with warm boiled water, 7 days courses for the treatment of.Take 21 days, patients ' vomiting alleviates, and alopecia also alleviates; Take 2 months, patient's malaise symptoms fades away, and acra sensation is sensitive comparatively before; Continue to take 2 months, patient's symptom that feels uneasy disappears completely.
The Chinese medicine composition of embodiment 4 ameliorate tumor chemotherapy of patients side reaction, takes off the primary raw material stating weight proportion and is prepared from (every part of 40g): QINGZHU eats 9 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, Rhizoma Coptidis 6 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Radix Et Rhizoma Rhei 4 parts, Herba Equiseti Hiemalis 8 parts, Cortex Magnoliae Officinalis 9 parts, Indigo Naturalis 5 parts, Rhizoma Cyperi (vinegar) 6 parts, Myrrha 12 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Membrana Follicularis ovi 12 parts, Radix Carpesii 6 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.
The preparation method of the Chinese medicine composition tablet of above-mentioned ameliorate tumor chemotherapy of patients side reaction is:
(1) Radix Et Rhizoma Rhei, Indigo Naturalis are ground into fine powder respectively, cross 105 mesh sieves;
(2) QINGZHU is eaten, the Rhizoma Atractylodis Macrocephalae (parched with bran), Rhizoma Coptidis, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Equiseti Hiemalis, Cortex Magnoliae Officinalis, Rhizoma Cyperi (vinegar), Myrrha, Radix Aucklandiae (Radix Vladimiriae), Membrana Follicularis ovi, Radix Carpesii and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) co-grinding cross 110 mesh sieves;
(3) step (1) and (2) gained are mixed to obtain powder;
(4) step (3) gained powder is measured according to 0.4g/ sheet, be pressed into the tablet dosage form of circle or other shapes according to the preparation for processing of tablet.
Tablets instructions of taking: tablet adopts every day 3 times, each 5-8 sheet, with warm boiled water, 7 days courses for the treatment of.
Model case four woods XX, age: 37 years old, sex: man.Patient carries out artificial femoral head replacement surgery because of giant cell tumor of bone in February, 2008, in July, 2008, tumor extensively shifted to two lung, in August, 2008 CT Pulmonary metastasis focuses maximum gauge 14 × 14cm, heating, cough with asthma, general pain, relieving the pain caused by diseases is carried out by chemotherapy, but chemotherapy causes some side reactions: weak all over, lethargy, appetite are low and with phenomenons such as nausea and vomiting, take anti-chemotherapy side effect medicine, all without positive effect.Take the Chinese medicine composition tablet of the present embodiment gained ameliorate tumor chemotherapy of patients side reaction, adopt every day 3 times, each 8, with warm boiled water, 7 days courses for the treatment of.Take 15 days, patient's malaise symptoms alleviates to some extent, and food of receiving is gradually many; Take 1 month, nausea and vomiting phenomenon disappears, and the mental status is improved, and malaise symptoms fades away; Continue to take 2 months, patient's self-induction is without side reaction.
The Chinese medicine composition of embodiment 5 ameliorate tumor chemotherapy of patients side reaction, takes off the primary raw material stating weight proportion and is prepared from (every part of 50g): QINGZHU eats 9 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, Rhizoma Coptidis 6 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Radix Et Rhizoma Rhei 4 parts, Herba Equiseti Hiemalis 8 parts, Cortex Magnoliae Officinalis 9 parts, Indigo Naturalis 5 parts, Rhizoma Cyperi (vinegar) 6 parts, Myrrha 12 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Membrana Follicularis ovi 12 parts, Radix Carpesii 6 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.
The preparation method of the Chinese medicinal composition capsules of above-mentioned ameliorate tumor chemotherapy of patients side reaction is:
(1) Radix Et Rhizoma Rhei, Indigo Naturalis are ground into fine powder respectively, cross 105 mesh sieves;
(2) QINGZHU is eaten, the Rhizoma Atractylodis Macrocephalae (parched with bran), Rhizoma Coptidis, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Equiseti Hiemalis, Cortex Magnoliae Officinalis, Rhizoma Cyperi (vinegar), Myrrha, Radix Aucklandiae (Radix Vladimiriae), Membrana Follicularis ovi, Radix Carpesii and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) co-grinding cross 110 mesh sieves;
(3) step (1) and (2) gained are mixed to obtain powder;
(4) step (3) gained powder is measured according to 0.5g/ grain, be processed into capsule shape dosage form according to the preparation for processing of capsule.
Capsule instructions of taking of the present invention: capsule adopts every day 3 times, each 6-10 grain, with warm boiled water, 7 days courses for the treatment of.
Model case five Wu XX, age: 55 years old, sex: female.Within 2010, find right tonsil malignant lymphoma, through chemotherapy, swollen thing disappears, the side reactions such as the vomiting but chemotherapy causes nausea, appetite are low, drowsiness, lassitude.For alleviating the side reaction that chemotherapy causes, patient takes the Chinese medicinal composition capsules agent of the present embodiment gained ameliorate tumor chemotherapy of patients side reaction, adopts every day 3 times, each 10, with warm boiled water, and 7 days courses for the treatment of.Take 1 month, patients ' vomiting alleviates, and drowsiness situation also alleviates; Take 2 months, malaise symptoms improves, and the mental status takes a turn for the better; Continue to take 2 months, patient is without malaise symptoms.
The Chinese medicine composition of embodiment 6 ameliorate tumor chemotherapy of patients side reaction, takes off the primary raw material stating weight proportion and is prepared from (every part of 60g): QINGZHU eats 9 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, Rhizoma Coptidis 6 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Radix Et Rhizoma Rhei 4 parts, Herba Equiseti Hiemalis 8 parts, Cortex Magnoliae Officinalis 9 parts, Indigo Naturalis 5 parts, Rhizoma Cyperi (vinegar) 6 parts, Myrrha 12 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Membrana Follicularis ovi 12 parts, Radix Carpesii 6 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.
The preparation method of the Chinese medicine composition water preparation of above-mentioned ameliorate tumor chemotherapy of patients side reaction is:
(1) Radix Et Rhizoma Rhei, Indigo Naturalis are ground into fine powder respectively, cross 105 mesh sieves;
(2) QINGZHU is eaten, the Rhizoma Atractylodis Macrocephalae (parched with bran), Rhizoma Coptidis, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Equiseti Hiemalis, Cortex Magnoliae Officinalis, Rhizoma Cyperi (vinegar), Myrrha, Radix Aucklandiae (Radix Vladimiriae), Membrana Follicularis ovi, Radix Carpesii and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) be placed in marmite, add water (water consumption is 3.5 times of crude drug gross weight) decoction 2 times, 1.8 hours first times, second time 1.0 hours, filtrate merges, and lets cool;
(3) Radix Et Rhizoma Rhei after step (1) being pulverized and Indigo Naturalis add step (2) gained medicinal liquid, sterile packaged.
Water preparation instructions of taking of the present invention: water preparation adopts every day 2 times (warm), each 300-500ml, 7 days courses for the treatment of.
The clinical practice of the Chinese medicine composition water preparation of test example 1 embodiment 6 gained ameliorate tumor chemotherapy of patients side reaction: in February ,-2012 in March, 2009,120 routine patients are screened, wherein women 61 example, male 59 example in 5 hospitals, oldest 76 years old, minimal ages 35 years old.Before test 3 weeks, carry out Continuous Observation to this crowd, record symptom and change, be divided into two groups at random, experimental group and matched group, experimental group takes embodiment 6 products obtained therefrom, and matched group takes other medicine conventional medication such as () holy liquid oral liquid, selenium Wei Kang.Using method is: take every day twice (warm), each 300m1-500m1(adjusts to some extent depending on concrete condition), 7 days courses for the treatment of.Curative effect situation criterion: cure: take a course for the treatment of of this product, malaise symptoms disappears, and energy and muscle power obviously strengthen; Effective: take a course for the treatment of of this product, malaise symptoms alleviates or partial disappearance, energy and muscle power strengthen; Invalid: take a course for the treatment of of this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1: take the checking of embodiment 6 products obtained therefrom therapeutic effect
Therapeutic effect: cure 71 examples (71%), effective 28 examples (28%), invalid 1 example (1%), total effective rate 99%.Successful is better than matched group.
Take period self-induction symptom and physical change of spirit as shown in table 2.
Table 2:
The present invention selects QINGZHU to eat, the Rhizoma Atractylodis Macrocephalae (parched with bran), Rhizoma Coptidis, Radix Salviae Miltiorrhizae, Membrana Follicularis ovi, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) etc. carry out compatibility, produces synergism after making these drug regimens, can more effectively ameliorate tumor chemotherapy of patients side reaction.Take 20 days, more than 53% feel takes a turn for the better to some extent, and malaise symptoms improves; Take 40 days, more than 74% feel takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen; Take 60 days, more than 97% feel takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen, and some patients self-induction is fully recovered.Take more than 60 days in experimental group, effective percentage can reach 95%, and matched group is only 75%.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (2)

1. the Traditional Chinese medicine composition paste of ameliorate tumor chemotherapy of patients side reaction, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from (every part of 20g): QINGZHU eats 9 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, Rhizoma Coptidis 6 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Radix Et Rhizoma Rhei 4 parts, Herba Equiseti Hiemalis 8 parts, Cortex Magnoliae Officinalis 9 parts, Indigo Naturalis 5 parts, Rhizoma Cyperi (vinegar) 6 parts, Myrrha 12 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Membrana Follicularis ovi 12 parts, Radix Carpesii 6 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.
2. the preparation method of the Traditional Chinese medicine composition paste of ameliorate tumor chemotherapy of patients side reaction, is characterized in that:
(1) Radix Et Rhizoma Rhei, Indigo Naturalis are ground into fine powder respectively, cross 105 mesh sieves;
(2) QINGZHU is eaten, the Rhizoma Atractylodis Macrocephalae (parched with bran), Rhizoma Coptidis, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Equiseti Hiemalis, Cortex Magnoliae Officinalis, Rhizoma Cyperi (vinegar), Myrrha, Radix Aucklandiae (Radix Vladimiriae), Membrana Follicularis ovi, Radix Carpesii and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) be placed in marmite, add water (water consumption is 3.5 times of crude drug gross weight) decoction 2 times, 1.8 hours first times, second time 1.0 hours, filtrate merges, filter, concentrated that relative density is 1.36-1.38(48 DEG C) clear paste;
(3) Radix Et Rhizoma Rhei after step (1) being pulverized and Indigo Naturalis add step (2) gained clear paste, sterile packaged.
CN201510947575.9A 2014-04-12 2014-04-12 Composition paste agent for mitigating side effects of chemotherapy for tumor patient Withdrawn CN105535578A (en)

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