CN105535645A - Traditional Chinese medicine composition taken by patient with pancreatic cancer during radiotherapy and chemotherapy and preparation method thereof - Google Patents
Traditional Chinese medicine composition taken by patient with pancreatic cancer during radiotherapy and chemotherapy and preparation method thereof Download PDFInfo
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- CN105535645A CN105535645A CN201610058013.3A CN201610058013A CN105535645A CN 105535645 A CN105535645 A CN 105535645A CN 201610058013 A CN201610058013 A CN 201610058013A CN 105535645 A CN105535645 A CN 105535645A
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Abstract
The invention discloses a traditional Chinese medicine composition taken by a patient with pancreatic cancer during radiotherapy and chemotherapy. The traditional Chinese medicine composition is prepared from the following main raw materials in parts by weight: 6-13 parts of cowherb seed, 8-12 parts of herba hyperici, 5-13 parts of linear stonecrop herb, 4-8 parts of Szechwan chinaberry fruit, 8-14 parts of corn stigma, 6-12 parts of Indian trumetflower seed, 7-13 parts of herba rabdosiae, 9-12 parts of rhizome of black bamboo, 5-10 parts of silktree albizzia bark, 3-7 parts of fruit or seed of siberian elm, 5-11 parts of herb of jamaica falsevalerian, 4-7 parts of (roasted) turtle shell, 6-11 parts of all-grass of maidenhair, 3-10 parts of microcos paniculata and 5-12 parts of root of evans begonia, The traditional Chinese medicine composition taken by the patient with the pancreatic cancer during the radiotherapy and chemotherapy has the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis and removing stasis, and also has the functions of effectively inhibiting the growth of cancel cells, controlling the spreading and transfer of tumors, reinforcing the immunity and releasing the pain of the patient.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to Chinese medicine composition and method for making that a kind of Pancreas cancer patients radiation period takes.
Background technology
Cancer of pancreas be growth in the malignant tumor of external pancreatic secretion gonad, this is common cancer, and in 2002, the disease of this kind of high malignancy was died from the whole world approximately nearly 227,000 patient, only has small number of patients can rehabilitation.40-70 year is common, and male is more than women.Sickness rate has and increases trend in recent years.Spinal column is close at the rear that pancreas is positioned at epigastrium stomach, and Diseases In Pancreatic Head is held by duodenal segment, and carcinoma accounts for 2/3 more than herein, and 90% is duct cell carcinoma.The cause of disease is still not fully aware of, its occur with smoking, drink, higher fatty acid relevant with high protein diet, excessive coffee for drinking, environmental pollution and inherited genetic factors.Investigation report in recent years finds that the sickness rate of cancer of pancreas in diabetic population is apparently higher than general population; Also someone notices that the morbidity of chronic pancreatitis patient and cancer of pancreas exists certain relation, and the ratio that cancer of pancreas occurs discovery chronic pancreatitis patient obviously increases; Also have that many factors are sick therewith has certain relation, as occupation, environment, geography etc. in addition.
Cancer of pancreas clinical manifestation depend on the position of cancer, the course of disease sooner or later, the situation of to involve with or without transfer and adjacent organs.Its clinical characters is that the whole course of disease is short, PD worsens soon and rapidly.The most common is the glutted discomfort of epigastrium, pain.Although there is conscious pain, not all patient has tenderness, if there is tenderness, is consistent with the position of conscious pain.Stomachache is the cardinal symptom of cancer of pancreas, and minority case main suit is left and right lower abdomen, umbilicus all or entirely suffer from abdominal pain.Jaundice is the important symptom of cancer of pancreas particularly carcinoma of head of pancreas, is Progressive symmetric erythrokeratodermia, though can have slight fluctuations, can not disappears completely.What symptom of digestive tract was the most common is inappetence, and next has Nausea and vomiting, can have diarrhoea or constipation even melena, and diarrhoea is usually steatorrhea.In addition, patient often tells heating, obviously weak.
At present, also have a lot for Pancreas cancer patients radiation period drug administration, publication number CN104524420A(application number 201510051384.4) patent document discloses a kind of Local advanced pancreatic carcinoma conformal modulating radiotherapy enhanced sensitivity, subtract pain pharmaceutical composition, described pharmaceutical composition is made up of FUFANG KUSHEN ZHUSHEYE and clear pancreas indigestion eliminating granules.Publication number CN104587390A (application number 201510011907.2) patent document discloses a kind of Chinese medicine formula for the treatment of cancer of pancreas and preparation method thereof, formulated by the raw material of Chinese medicine of following parts by weight: Herba Hedyotidis Diffusae 5-10 part, Herba Scutellariae Barbatae 5-8 part, Rhizoma Smilacis Chinensis 5-8 part, Rabdosia japonica 3-8 part, Maytenus confertflora J. Y. Luo et X X Chen. 3-8 part, Rhizoma Paridis 3-8 part, Herba Duchesneae Indicae 3-5 part, Rhizoma Atractylodis Macrocephalae (parched) 3-5 part, Radix Curcumae 3-5 part, Herba Artemisiae Scopariae 3-5 part, spend Herba Bidentis Bipinnatae 3-5 part in vain, Herba Euphorbiae Humifusae 3-5 part, Herba Erigerontis 3-5 part, Radix Puerariae 3-5 part, Herba Hordei Vulgaris 3-6 part, Ganoderma 3-6 part, Radix Fissistigmatis Glaucescentis 3-6 part.Publication number CN1036110911A (application number 201310669009.7) patent document discloses a kind of Chinese medicine composition for the treatment of cancer of pancreas, 1. the crude drug of its Chinese medicine is made up of the component of following weight parts proportioning: Semen Ziziphi Spinosae 240-270 part, Radix Astragali 100-115 part, Radix Codonopsis 100-115 part, Rhizoma Atractylodis Macrocephalae 65-80 part, Semen Coicis core 100-115 part, Herba Hedyotidis Diffusae 100-115 part, Poria 75-85 part, Fructus Akebiae 75-85 part, Herba Scutellariae Barbatae 95-110 part, Herba Salviae Chinensis 75-85 part, Radix Polygalae 60-75 part, Radix Glycyrrhizae 20-25 part, Radix Bupleuri 120-145 part, Rhizoma Cyperi 40-55 part, Radix Curcumae 40-55 part, Fructus Citri Sarcodactylis 45-60 part, Herba Lobeliae Chinensis 70-85 part, Rhizoma Corydalis 45-60 part, Rhizoma Chuanxiong 25-30 part, Pericarpium Citri Reticulatae 14-19 part, Rhizoma Pinelliae 100-115 part, Cortex Magnoliae Officinalis 8-13 part, Flos Calystegiae sepii 60-75 part, Radix Paeoniae Alba 28-35 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 65-80 part.
The treatment of current cancer of pancreas does not also have a kind of comprehensive therapeutic plan efficiently can applied completely, and still based on surgical operation therapy, radiotherapy, chemotherapy are auxiliary.But because of the early diagnosis difficulty of cancer of pancreas, Resection Rate is low, prognosis mala, and survival rates is also low; Chemicotherapy effectively can kill cancerous cell, but also can kill and wound normal cell simultaneously, makes the immunity degradation of patient, occurs more complication, bring very big damage to patient body.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is the Chinese medicine composition providing Pancreas cancer patients radiation period to take, and has effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, removing mass eliminating stagnation, effective anticancer growth, control tumor diffusion transfer, enhancing immunity, alleviates patient's misery.Another object is just to provide the preparation method of above-mentioned Chinese medicine composition.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
The Chinese medicine composition that Pancreas cancer patients radiation period is taken, takes off the primary raw material stating weight proportion and is prepared from: Semen Vaccariae 6-13 part; Herba Hyperici 8-12 part; Flame grass 5-13 part; Fructus Toosendan 4-8 part; Stigma Maydis 8-14 part; Semen Oroxyli 6-12 part; Rabdosia rubescens 7-13 part; Rhizoma phyllostachydis nigrae 9-12 part; Cortex Albiziae 5-10 part; Fructus seu semen ulmi pumilae 3-7 part; Herba Stachytarphetae Jamaicensis 5-11 part; (processing) Carapax Trionycis 4-7 part; Herba Adianti 6-11 part; Folium Microcoris paniculatae 3-10 part; Radix Bischofiae Javanicae 5-12 part.
The Chinese medicine composition that Pancreas cancer patients radiation period is taken, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Semen Vaccariae 9-11 part; Herba Hyperici 9-11 part; Flame grass 8-10 part; Fructus Toosendan 5-7 part; Stigma Maydis 10-12 part; Semen Oroxyli 8-10 part; Rabdosia rubescens 9-11 part; Rhizoma phyllostachydis nigrae 10-11 part; Cortex Albiziae 7-9 part; Fructus seu semen ulmi pumilae 4-6 part; Herba Stachytarphetae Jamaicensis 7-9 part; (processing) Carapax Trionycis 5-6 part; Herba Adianti 8-10 part; Folium Microcoris paniculatae 6-8 part; Radix Bischofiae Javanicae 8-10 part.
The Chinese medicine composition that Pancreas cancer patients radiation period is taken, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: Semen Vaccariae 10 parts; Herba Hyperici 10 parts; Flame grass 9 parts; Fructus Toosendan 6 parts; Stigma Maydis 11 parts; Semen Oroxyli 9 parts; Rabdosia rubescens 10 parts; Rhizoma phyllostachydis nigrae 10.5 parts; Cortex Albiziae 8 parts; Fructus seu semen ulmi pumilae 5 parts; Herba Stachytarphetae Jamaicensis 8 parts; (processing) Carapax Trionycis 5.5 parts; Herba Adianti 9 parts; Folium Microcoris paniculatae 7 parts; Radix Bischofiae Javanicae 9 parts.
Present invention also offers the preparation method Chinese medicine composition that above-mentioned Pancreas cancer patients radiation period is taken being made pharmaceutically acceptable oral liquid, granule, capsule, pill and tablet.
The preparation method of the Chinese medicine composition oral liquid that described Pancreas cancer patients radiation period is taken, step is as follows:
(1) Semen Vaccariae, Semen Oroxyli and Fructus seu semen ulmi pumilae are carried out microwave combustion method 15-20 minute, dry, be placed in pulverizer and pulverize, excessively 180-220 mesh sieve (preferred 190-210 mesh sieve excessively, was more preferably 220 mesh sieves);
(2) Herba Hyperici, flame grass and Herba Stachytarphetae Jamaicensis are placed in drying machine dry (preferred baking temperature is 65-75 DEG C, and being more preferably baking temperature is 70 DEG C), burn into ashes completely, add water boil 50-60 minute, leave standstill 20-30 minute, remove the impurity on surface, get supernatant, for subsequent use;
(3) Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae are smashed, be placed in container, add water (consumption of preferred water be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 2-4 doubly, the consumption being more preferably water be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 3 times), soak 3-5 hour, squeezing extracting juice, add step (1) gained medicated powder, moistening 40-60 minute, filters, obtains medicinal liquid;
(4) Stigma Maydis, Rabdosia rubescens, Cortex Albiziae, (processing) Carapax Trionycis, Herba Adianti and Folium Microcoris paniculatae are placed in marmite, add step (2) gained supernatant, soak 30-40 minute, decoct with water twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), filters, merge, obtain filtrate;
(5) by step (3) gained medicinal liquid and the mixing of step (4) gained filtrate, filter, sterile packaged.
According to preparation method recited above, step (1) preferably microwave combustion method frequency is 1800-2000MHz, and being more preferably microwave combustion method frequency is 1900MHz.
Instructions of taking: each 8-10ml, every day 3 times, 15 days courses for the treatment of.
The preparation method of the Chinese medicinal composition granules that described Pancreas cancer patients radiation period is taken, step is as follows:
(1) (preferred microwave combustion method frequency is 1800-2000MHz Semen Vaccariae, Semen Oroxyli and Fructus seu semen ulmi pumilae to be carried out microwave combustion method, being more preferably microwave combustion method frequency is 1900MHz) 15-20 minute, dry, be placed in pulverizer to pulverize, cross 180-220 mesh sieve (preferred 190-210 mesh sieve excessively, was more preferably 220 mesh sieves);
(2) Herba Hyperici, flame grass and Herba Stachytarphetae Jamaicensis are placed in drying machine dry (preferred baking temperature is 65-75 DEG C, and being more preferably baking temperature is 70 DEG C), burn into ashes completely, add water boil 50-60 minute, leave standstill 20-30 minute, remove the impurity on surface, get supernatant, for subsequent use;
(3) Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae are smashed, be placed in container, add water, soak 3-5 hour, squeezing extracting juice, adds step (1) gained medicated powder, moistening 40-60 minute, filters, obtains medicinal liquid;
(4) Stigma Maydis, Rabdosia rubescens, Cortex Albiziae, (processing) Carapax Trionycis, Herba Adianti and Folium Microcoris paniculatae are placed in marmite, add step (2) gained supernatant, soak 30-40 minute, decoct with water twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), filters, merge, obtain filtrate;
(5) by step (3) gained medicinal liquid and step (4) gained filtrate mixing, be concentrated into relative density 1.10-1.20(30 DEG C) thick paste, make uniform fine particle, encapsulate with the specification of every parcel 6g.
According to preparation method recited above, the consumption of step (3) preferred water be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 2-4 doubly, the consumption being more preferably water be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 3 times.
Instructions of taking: each 1 parcel, with the warm boiled water of 35-45 DEG C, every day 3 times, 15 days courses for the treatment of.
The preparation method of the Chinese medicinal composition capsules that described Pancreas cancer patients radiation period is taken, step is as follows:
(1) (preferred microwave combustion method frequency is 1800-2000MHz Semen Vaccariae, Semen Oroxyli and Fructus seu semen ulmi pumilae to be carried out microwave combustion method, being more preferably microwave combustion method frequency is 1900MHz) 15-20 minute, dry, be placed in pulverizer to pulverize, cross 180-220 mesh sieve (preferred 190-210 mesh sieve excessively, was more preferably 220 mesh sieves);
(2) Herba Hyperici, flame grass and Herba Stachytarphetae Jamaicensis are placed in drying machine dry (preferred baking temperature is 65-75 DEG C, and being more preferably baking temperature is 70 DEG C), burn into ashes completely, add water boil 50-60 minute, leave standstill 20-30 minute, remove the impurity on surface, get supernatant, for subsequent use;
(3) Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae are smashed, be placed in container, add water (consumption of preferred water be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 2-4 doubly, the consumption being more preferably water be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 3 times), soak 3-5 hour, squeezing extracting juice, add step (1) gained medicated powder, moistening 40-60 minute, filters, obtains medicinal liquid;
(4) Stigma Maydis, Rabdosia rubescens, Cortex Albiziae, (processing) Carapax Trionycis, Herba Adianti and Folium Microcoris paniculatae are placed in marmite, add step (2) gained supernatant, soak 30-40 minute, decoct with water twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), filters, merge, obtain filtrate;
(5) by step (3) gained medicinal liquid and the mixing of step (4) gained filtrate, be concentrated into relative density 1.10-1.20(30 DEG C) thick paste, dry, pulverize, cross 180-220 mesh sieve (preferred cross 190-210 mesh sieve, be more preferably 200 mesh sieves);
(6) step (5) gained medicated powder is made capsule (preferably by the specification of 0.45-0.55g/ grain, being more preferably the specification by 0.5g/ grain) by the specification of 0.4-0.6g/ grain.
Instructions of taking: each 2, every day 3 times, 15 days courses for the treatment of.
The preparation method of the Chinese medicine composition pill that described Pancreas cancer patients radiation period is taken, step is as follows:
(1) (preferred microwave combustion method frequency is 1800-2000MHz Semen Vaccariae, Semen Oroxyli and Fructus seu semen ulmi pumilae to be carried out microwave combustion method, being more preferably microwave combustion method frequency is 1900MHz) 15-20 minute, dry, be placed in pulverizer to pulverize, cross 180-220 mesh sieve (preferred 190-210 mesh sieve excessively, was more preferably 220 mesh sieves);
(2) Herba Hyperici, flame grass and Herba Stachytarphetae Jamaicensis are placed in drying machine dry (preferred baking temperature is 65-75 DEG C, and being more preferably baking temperature is 70 DEG C), burn into ashes completely, add water boil 50-60 minute, leave standstill 20-30 minute, remove the impurity on surface, get supernatant, for subsequent use;
(3) Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae are smashed, be placed in container, add water (consumption of preferred water be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 2-4 doubly, the consumption being more preferably water be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 3 times), soak 3-5 hour, squeezing extracting juice, add step (1) gained medicated powder, moistening 40-60 minute, filters, obtains medicinal liquid;
(4) Stigma Maydis, Rabdosia rubescens, Cortex Albiziae, (processing) Carapax Trionycis, Herba Adianti and Folium Microcoris paniculatae are placed in marmite, add step (2) gained supernatant, soak 30-40 minute, decoct with water twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), filters, merge, obtain filtrate;
(5) by step (3) gained medicinal liquid and the mixing of step (4) gained filtrate, be concentrated into relative density 1.10-1.20(30 DEG C) thick paste, dry, pulverize, cross 120-140 mesh sieve;
(6) by Mel, (consumption of preferred Mel is the 10%-20% of medicated powder quality, the consumption being more preferably Mel is 15% of medicated powder quality) be placed in pot, temper with slow fire, endure to thick Deng Mel, mix step (5) gained medicated powder again, fully mix into ointment thoroughly, (preferred diameter is 3-5mm to make pill, being more preferably diameter is 4mm), obtain pill.
Instructions of taking: each 6-10 ball, every day 3 times, 15 days courses for the treatment of.
The preparation method of the Chinese medicine composition tablet that described Pancreas cancer patients radiation period is taken, step is as follows:
(1) (preferred microwave combustion method frequency is 1800-2000MHz Semen Vaccariae, Semen Oroxyli and Fructus seu semen ulmi pumilae to be carried out microwave combustion method, being more preferably microwave combustion method frequency is 1900MHz) 15-20 minute, dry, be placed in pulverizer to pulverize, cross 180-220 mesh sieve (preferred 190-210 mesh sieve excessively, was more preferably 220 mesh sieves);
(2) Herba Hyperici, flame grass and Herba Stachytarphetae Jamaicensis are placed in drying machine dry (preferred baking temperature is 65-75 DEG C, and being more preferably baking temperature is 70 DEG C), burn into ashes completely, add water boil 50-60 minute, leave standstill 20-30 minute, remove the impurity on surface, get supernatant, for subsequent use;
(3) Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae are smashed, be placed in container, add water (consumption of preferred water be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 2-4 doubly, the consumption being more preferably water be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 3 times), soak 3-5 hour, squeezing extracting juice, add step (1) gained medicated powder, moistening 40-60 minute, filters, obtains medicinal liquid;
(4) Stigma Maydis, Rabdosia rubescens, Cortex Albiziae, (processing) Carapax Trionycis, Herba Adianti and Folium Microcoris paniculatae are placed in marmite, add step (2) gained supernatant, soak 30-40 minute, decoct with water twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), filters, merge, obtain filtrate;
(5) by step (3) gained medicinal liquid and step (4) gained filtrate mixing, be concentrated into relative density 1.10-1.20(30 DEG C) thick paste, make uniform granule, tabletting, sugar coating, make tablet.
Instructions of taking: each 2-3 sheet, every day 3 times, 15 days courses for the treatment of.
The pharmacological effect of each crude drug is respectively:
Semen Vaccariae: bitter in the mouth, property is put down.Return liver, stomach warp.For the dry mature seed of pinkwort Vaccaria segetalis.There is promoting blood circulation to restore menstrual flow, effect of stimulating milk secretion detumescence.For agalactia, amenorrhea, dysmenorrhea, acute mastitis swells and ache.
Herba Hyperici: bitter in the mouth, cold in nature.Return Liver Channel.For the herb of Garcinia maingayii hypericum ascyron.There is cooling blood for hemostasis, promoting blood flow to regulate menstruation, effect of heat-clearing and toxic substances removing.Spit blood caused by heat in blood, spitting of blood, hematuria, has blood in stool, metrorrhagia, traumatic injury, traumatic hemorrhage, menoxenia, dysmenorrhea, agalactia, anemopyretic cold, malaria, hepatitis, dysentery, diarrhoea, and venom is scalded, eczema, impetigo.
Flame grass: mildly bitter flavor, cool in nature.For the herb of crassulaceae plants flame grass.There is heat-clearing and toxic substances removing, effect of cooling blood for hemostasis.For pathopyretic ulcer, acute mastitis, erysipelas, innominate toxic swelling, burn due to hot liquid or fire, laryngopharynx swelling and pain, gingivitis, heat in blood is spitted blood, spitting of blood, epistaxis, traumatic hemorrhage.
Fructus Toosendan: bitter in the mouth, cold in nature.Return liver, small intestinal, urinary bladder channel.Another name is Fructus Toosendan, Fructus Toosendan, Fructus Toosendan are real.For the dry mature fruit of Meliaceae plant Fructus Toosendan, primary medicinal component is Fructus Toosendan element, alkaloid etc.There are soothing liver-QI promoting the circulation of QI to relieve pain, effect of anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.Bitter cold is fallen and is let out, can clearing away liver-fire, let out hot and suffocating, promoting the circulation of QI to relieve pain.
Stigma Maydis: sweet in the mouth, light, property is put down.Return kidney, stomach, liver, gallbladder meridian.For the zeistic style of grass and stigma.There is inducing diuresis to remove edema, effect of liver heat removing function of gallbladder promoting.For edema, dribbling urination, jaundice, cholecystitis, cholelithiasis, hypertension, diabetes, galactostasis.
Semen Oroxyli: bitter in the mouth, sweet, cool in nature.Return lung, liver, stomach warp.For the dry mature seed of Bignoniaceae plant oroxylum indicum.There is removing heat from the lung and relieving sorethroat, effect of dispersing the stagnated liver-QI for regulating the stomach.For cough due to lung-heat, sore throat, hoarseness, stomachache due to hyperactive liver-QI attacking the stomach.
Rabdosia rubescens: bitter in the mouth, sweet, cold nature.For labiate is cracked rice the herb of fork.There is heat-clearing and toxic substances removing, effect of promoting blood circulation and stopping pain.For laryngopharynx swelling and pain, headache due to common cold, tracheitis, chronic hepatitis, rheumatic arthritis, snake bite and insect sting.
Rhizoma phyllostachydis nigrae: acrid in the mouth, light, cool in nature.For the rhizome of grass black bamboo.There is expelling wind and removing dampness, effect of promoting blood circulation and detoxication.For beriberoid pyretic arthralgia, muscles and bones is ached, amenorrhea, lump in the abdomen, lyssodexis.
Cortex Albiziae: sweet in the mouth, property is put down.GUIXIN, liver, lung meridian.For the dry bark of leguminous plant Herba Albiziae.There is resolving stagnation for tranquilization, effect of promoting blood circulation and detumescence.For irritability, melancholy insomnia, lung abscess skin ulcer swells, and falls and flutters the pain of injury.
Fructus seu semen ulmi pumilae: bitter in the mouth, micro-pungent, property is put down.For the fruits and seeds of Ulmaceae elm.There is spleen-benefiting mind-tranquilizing, clearing away heat and promoting diuresis, effect of detumescence parasite killing.For women leucorrhea, children's's infantile malnutrition with fever weakness and emaciation, insomnia, inappetence, leukorrhagia, dysuria, edema, children's's infantile malnutrition with fever is won thin, burn and scald, skin ulcer tinea.
Herba Stachytarphetae Jamaicensis: sweet in the mouth, micro-hardship, cold in nature.GUIXIN, liver, kidney channel.For herb and the root of the false horsewhip of Verbenaceae.There is clearing away heat-damp and promoting diuresis, effect of removing toxic substances and promoting subsidence of swelling.For pyretic stranguria, stranguria caused by urinary stone, nebulousurine, leucorrhea, rheumatic ostalgia, acute conjunctivitis, pharyngolaryngitis, gingivitis, cholecystitis, carbuncle furuncle, hemorrhoid, treating swelling and pain by traumatic injury.
(processing) Carapax Trionycis: salty in the mouth, cold nature.Return liver, kidney channel.For the carapace of Trionychidae animal Trionyx sinensis (Wiegmann) and Trionyxs teindachneri Siebenrock．.There is nourishing YIN and clearing away heat, suppressing hyper-yang to eliminate wind, effect of hard masses softening and resolving.For fever due to yin deficiency, consumptive fever hectic fever due to YIN-deficiency, consumption of YIN caused by febrile disease, stirring-up of pathogenic wind in the interior resulting from deficiency, littlely makes infantile convulsion, chronic malaria, malaria with splenomegaly, lump in the abdomen, amenorrhea.Carapax Trionycis (processed): get sand and put in pot, after making popular with high heat, adds clean Carapax Trionycis, constantly stirs, scald to surface faint yellow, takes out, and sieve removes sand, quench in vinegar, and dry, the used time smashs to pieces.Every Carapax Trionycis 100kg, uses vinegar 20kg.
Herba Adianti: bitter in the mouth, cool in nature.Return liver, kidney channel.For the herb of adiantaceae plant iron Colysis ellipiica (Thunb.) Chingpolypodium ellipticum Thumb., white back iron Colysis ellipiica (Thunb.) Chingpolypodium ellipticum Thumb..There is heat-clearing and toxic substances removing, effect of relieving stranguria by diuresis.For cold, fever, cough due to lung-heat, diarrhea due to damp-heat, dysentery, stranguria with turbid discharge, leukorrhagia, acute mastitis, scrofula, furunculosis, scalds, venom.
Folium Microcoris paniculatae: sour in the mouth, light, property is put down.Return spleen channel.For the leaf of Tiliaceae plant Folium Microcoris paniculatae.Have clearing away heat-damp and promoting diuresis, stomach invigorating disappears stagnant effect.For cold, fever, jaundice, inappetence, dyspepsia, abdominal distention, has loose bowels, skin infection, centipete bite.
Radix Bischofiae Javanicae: sour in the mouth, puckery, property is put down.For the root of Begoniaceae plant Flos Begoniae Evansianae.There is blood stasis dispelling, hemostasis, effect of clearing away heat-damp and promoting diuresis.For traumatic injury, spit blood, spitting of blood, epistaxis, knife injury is hemorrhage, metrorrhagia, blood stasis amenorrhea, menoxenia, leukorrhagia, stranguria with turbid discharge, dysentery, stomachache, laryngopharynx swelling and pain.
Beneficial effect of the present invention is mainly reflected in:
1, Chinese medicine composition of the present invention has effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, removing mass eliminating stagnation, and effective anticancer growth, control tumor diffusion transfer, enhancing immunity, alleviates patient's misery.
2, Chinese medicine composition of the present invention has enhanced sensitivity and subtracts pain effect, can improve the radiosensitivity of cancer of pancreas, reduction of patient pain, suppress the propagation of cancer of pancreas and diffusion.
3, Chinese medicine composition of the present invention effectively can strengthen the immunity of patient, reduces the injury that patient's normal structure when accepting radiotherapy is subject to, and reduces the incidence rate of complication.
4, Chinese medicine composition employing Common Chinese Herbs of the present invention is refining forms, and cost is low, rapid-action, good effect, taking convenience.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
The Chinese medicine composition that embodiment 1 Pancreas cancer patients radiation period is taken, takes off and states primary raw material and be prepared from (getting 70g for every part): Semen Vaccariae 6 parts; Herba Hyperici 8 parts; Flame grass 5 parts; Fructus Toosendan 4 parts; Stigma Maydis 8 parts; Semen Oroxyli 6 parts; Rabdosia rubescens 7 parts; Rhizoma phyllostachydis nigrae 9 parts; Cortex Albiziae 5 parts; Fructus seu semen ulmi pumilae 3 parts; Herba Stachytarphetae Jamaicensis 5 parts; (processing) Carapax Trionycis 4 parts; Herba Adianti 6 parts; Folium Microcoris paniculatae 3 parts; Radix Bischofiae Javanicae 5 parts.
The preparation method of the Chinese medicine composition oral liquid that above-mentioned Pancreas cancer patients radiation period is taken, step is as follows:
(1) Semen Vaccariae, Semen Oroxyli and Fructus seu semen ulmi pumilae are carried out microwave combustion method (microwave combustion method frequency is 1900MHz) 18 minutes, dry, be placed in pulverizer and pulverize, cross 200 mesh sieves;
(2) Herba Hyperici, flame grass and Herba Stachytarphetae Jamaicensis are placed in drying machine dry (baking temperature is 65 DEG C), burn into ashes completely, add water boil 55 minutes, leave standstill 25 minutes, remove the impurity on surface, get supernatant, for subsequent use;
(3) Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae are smashed, be placed in container, add water (consumption be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 3 times), soak 4 hours, squeezing extracting juice, adds step (1) gained medicated powder, moistening 50 minutes, filters, obtains medicinal liquid;
(4) be placed in marmite by Stigma Maydis, Rabdosia rubescens, Cortex Albiziae, (processing) Carapax Trionycis, Herba Adianti and Folium Microcoris paniculatae, add step (2) gained supernatant, soak 35 minutes, decoct with water twice, each decoction 35 minutes, filters, and merges, obtains filtrate;
(5) by step (3) gained medicinal liquid and the mixing of step (4) gained filtrate, filter, sterile packaged.
Instructions of taking: each 8-10ml, every day 3 times, 15 days courses for the treatment of.
The Chinese medicine composition that embodiment 2 Pancreas cancer patients radiation period is taken, takes off and states primary raw material and be prepared from (getting 30g for every part): Semen Vaccariae 13 parts; Herba Hyperici 12 parts; Flame grass 13 parts; Fructus Toosendan 8 parts; Stigma Maydis 14 parts; Semen Oroxyli 12 parts; Rabdosia rubescens 13 parts; Rhizoma phyllostachydis nigrae 12 parts; Cortex Albiziae 10 parts; Fructus seu semen ulmi pumilae 7 parts; Herba Stachytarphetae Jamaicensis 11 parts; (processing) Carapax Trionycis 7 parts; Herba Adianti 11 parts; Folium Microcoris paniculatae 10 parts; Radix Bischofiae Javanicae 12 parts.
The preparation method of the Chinese medicinal composition granules that above-mentioned Pancreas cancer patients radiation period is taken, step is as follows:
(1) Semen Vaccariae, Semen Oroxyli and Fructus seu semen ulmi pumilae are carried out microwave combustion method (microwave combustion method frequency is 1900MHz) 18 minutes, dry, be placed in pulverizer and pulverize, cross 200 mesh sieves;
(2) Herba Hyperici, flame grass and Herba Stachytarphetae Jamaicensis are placed in drying machine dry (baking temperature is 70 DEG C), burn into ashes completely, add water boil 50 minutes, leave standstill 25 minutes, remove the impurity on surface, get supernatant, for subsequent use;
(3) Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae are smashed, be placed in container, add water (consumption be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 3 times), soak 4 hours, squeezing extracting juice, adds step (1) gained medicated powder, moistening 50 minutes, filters, obtains medicinal liquid;
(4) be placed in marmite by Stigma Maydis, Rabdosia rubescens, Cortex Albiziae, (processing) Carapax Trionycis, Herba Adianti and Folium Microcoris paniculatae, add step (2) gained supernatant, soak 35 minutes, decoct with water twice, each decoction 35 minutes, filters, and merges, obtains filtrate;
(5) by step (3) gained medicinal liquid and step (4) gained filtrate mixing, be concentrated into relative density 1.15(30 DEG C) thick paste, make uniform fine particle, encapsulate with the specification of every parcel 6g.
Instructions of taking: each 1 parcel, with the warm boiled water of 35-45 DEG C, every day 3 times, 15 days courses for the treatment of.
Model case one: the Meng XX, man, 53 years old, people from Heze city of Shandong province.Occurred discontinuity upper abdominal pain before 3 years, abdominal distention, usually with nausea and vomiting, heartburn and acid regurgitation, looks into B ultrasonic in locality and shows cholecystitis, and antiinflammatory antacid treatment treatment one week, all symptoms are without alleviation.Found that upper abdomen was full afterwards, upper right abdomen touches the swollen thing of an egg size, the tough tenderness of matter, inspection of transferring from one hospital to another, and B ultrasonic shows: pancreas enlargement, is diagnosed as cancer of pancreas eventually, implements excision operation, and operation smoothly.The time of leaving hospital latter about 1 year feels again uncomfortable, checks and finds cancer of pancreas recurrence, so carry out radiotherapy, period side reaction is strong, and effect is poor.
Afterwards, after radiation period starts to take 2 courses for the treatment of of Pancreas cancer patients radiation period of the present invention takes Chinese medicine composition (embodiment 2), side reaction was obviously alleviated, and Mr. Meng can feel at ease to have slept, and the mental status is also obviously improved, and rehabilitation efficacy is better.After continuing to take 2 courses for the treatment of, go hospital's further consultation, result display tumor cloud obviously reduces, and health greatly takes a turn for the better.Later stage follows up a case by regular visits to 1 year, does not occur other malaise symptoms, recovers good, and does not recur always.
The Chinese medicine composition that embodiment 3 Pancreas cancer patients radiation period is taken, takes off and states primary raw material and be prepared from (getting 60g for every part): Semen Vaccariae 9 parts; Herba Hyperici 9 parts; Flame grass 8 parts; Fructus Toosendan 5 parts; Stigma Maydis 10 parts; Semen Oroxyli 8 parts; Rabdosia rubescens 9 parts; Rhizoma phyllostachydis nigrae 10 parts; Cortex Albiziae 7 parts; Fructus seu semen ulmi pumilae 4 parts; Herba Stachytarphetae Jamaicensis 7 parts; (processing) Carapax Trionycis 5 parts; Herba Adianti 8 parts; Folium Microcoris paniculatae 6 parts; Radix Bischofiae Javanicae 8 parts.
The preparation method of the Chinese medicinal composition capsules that above-mentioned Pancreas cancer patients radiation period is taken, step is as follows:
(1) Semen Vaccariae, Semen Oroxyli and Fructus seu semen ulmi pumilae are carried out microwave combustion method (microwave combustion method frequency is 1900MHz) 18 minutes, dry, be placed in pulverizer and pulverize, cross 200 mesh sieves;
(2) Herba Hyperici, flame grass and Herba Stachytarphetae Jamaicensis are placed in drying machine dry (baking temperature is 70 DEG C), burn into ashes completely, add water boil 55 minutes, leave standstill 25 minutes, remove the impurity on surface, get supernatant, for subsequent use;
(3) Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae are smashed, be placed in container, add water (consumption be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 2 times), soak 4 hours, squeezing extracting juice, adds step (1) gained medicated powder, moistening 45 minutes, filters, obtains medicinal liquid;
(4) be placed in marmite by Stigma Maydis, Rabdosia rubescens, Cortex Albiziae, (processing) Carapax Trionycis, Herba Adianti and Folium Microcoris paniculatae, add step (2) gained supernatant, soak 35 minutes, decoct with water twice, each decoction 35 minutes, filters, and merges, obtains filtrate;
(5) by step (3) gained medicinal liquid and step (4) gained filtrate mixing, be concentrated into relative density 1.15(30 DEG C) thick paste, dry, pulverize, cross 200 mesh sieves;
(6) step (5) gained medicated powder is made capsule by the specification of 0.5g/ grain.
Using method: each 2, every day 3 times, 15 days courses for the treatment of.
The Chinese medicine composition that embodiment 4 Pancreas cancer patients radiation period is taken, takes off and states primary raw material and be prepared from (getting 20g for every part): Semen Vaccariae 11 parts; Herba Hyperici 11 parts; Flame grass 10 parts; Fructus Toosendan 7 parts; Stigma Maydis 12 parts; Semen Oroxyli 10 parts; Rabdosia rubescens 11 parts; Rhizoma phyllostachydis nigrae 11 parts; Cortex Albiziae 9 parts; Fructus seu semen ulmi pumilae 6 parts; Herba Stachytarphetae Jamaicensis 9 parts; (processing) Carapax Trionycis 6 parts; Herba Adianti 10 parts; Folium Microcoris paniculatae 8 parts; Radix Bischofiae Javanicae 10 parts.
The preparation method of the Chinese medicine composition pill that above-mentioned Pancreas cancer patients radiation period is taken, step is as follows:
(1) Semen Vaccariae, Semen Oroxyli and Fructus seu semen ulmi pumilae are carried out microwave combustion method (microwave combustion method frequency is 1900MHz) 18 minutes, dry, be placed in pulverizer and pulverize, cross 200 mesh sieves;
(2) Herba Hyperici, flame grass and Herba Stachytarphetae Jamaicensis are placed in drying machine dry (baking temperature is 70 DEG C), burn into ashes completely, add water boil 55 minutes, leave standstill 25 minutes, remove the impurity on surface, get supernatant, for subsequent use;
(3) Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae are smashed, be placed in container, add water (consumption be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 3 times), soak 4 hours, squeezing extracting juice, adds step (1) gained medicated powder, moistening 50 minutes, filters, obtains medicinal liquid;
(4) be placed in marmite by Stigma Maydis, Rabdosia rubescens, Cortex Albiziae, (processing) Carapax Trionycis, Herba Adianti and Folium Microcoris paniculatae, add step (2) gained supernatant, soak 35 minutes, decoct with water twice, each decoction 35 minutes, filters, and merges, obtains filtrate;
(5) by step (3) gained medicinal liquid and step (4) gained filtrate mixing, be concentrated into relative density 1.15(30 DEG C) thick paste, dry, pulverize, cross 130 mesh sieves;
(6) Mel (consumption is 15% of medicated powder quality) is placed in pot, tempers with slow fire, wait Mel to endure to thick, then mix step (5) gained medicated powder, fully mix into ointment thoroughly, make the pill that diameter is 4mm, obtain pill.
Instructions of taking: each 6-10 ball, every day 3 times, 15 days courses for the treatment of.
Model case two: XX suddenly, man, 59 years old, people from Dezhou City Shandong Province.Mr. Huo is businessman, and dinner party is many at ordinary times, and stress adds greatly and overworks, and health usually occurs discomfort.Fever was there is before 2 years, inappetence, abdominal part has a dull ache, and does not notice very much at that time, think diet unreasonable cause uncomfortable, until symptom obviously increases the weight of just to remove examination in hospital, result is diagnosed as cancer of pancreas, and after being treated surgically, the state of an illness is temporarily controlled, but the radiotherapy in later stage causes violent side reaction, Mr. Huo is made to can't bear to stand.
Afterwards after 2 courses for the treatment of of Chinese medicine composition (embodiment 4) that radiation period takes that Pancreas cancer patients radiation period of the present invention takes, the mental status had good improvement, and chest dull pain disappears.After continuing to take 2 courses for the treatment of, lump obviously reduces, and immune indexes platelet, leukocyte are also normal.Visit and learn that health is always fine.
The Chinese medicine composition that embodiment 5 Pancreas cancer patients radiation period is taken, takes off and states primary raw material and be prepared from (getting 40g for every part): Semen Vaccariae 10 parts; Herba Hyperici 10 parts; Flame grass 9 parts; Fructus Toosendan 6 parts; Stigma Maydis 11 parts; Semen Oroxyli 9 parts; Rabdosia rubescens 10 parts; Rhizoma phyllostachydis nigrae 10.5 parts; Cortex Albiziae 8 parts; Fructus seu semen ulmi pumilae 5 parts; Herba Stachytarphetae Jamaicensis 8 parts; (processing) Carapax Trionycis 5.5 parts; Herba Adianti 9 parts; Folium Microcoris paniculatae 7 parts; Radix Bischofiae Javanicae 9 parts.
The preparation method of the Chinese medicine composition tablet that above-mentioned Pancreas cancer patients radiation period is taken, step is as follows:
(1) Semen Vaccariae, Semen Oroxyli and Fructus seu semen ulmi pumilae are carried out microwave combustion method (microwave combustion method frequency is 1900MHz) 18 minutes, dry, be placed in pulverizer and pulverize, cross 220 mesh sieves;
(2) Herba Hyperici, flame grass and Herba Stachytarphetae Jamaicensis are placed in drying machine dry (baking temperature is 70 DEG C), burn into ashes completely, add water boil 55 minutes, leave standstill 25 minutes, remove the impurity on surface, get supernatant, for subsequent use;
(3) Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae are smashed, be placed in container, add water (consumption be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 3 times), soak 4 hours, squeezing extracting juice, adds step (1) gained medicated powder, moistening 50 minutes, filters, obtains medicinal liquid;
(4) be placed in marmite by Stigma Maydis, Rabdosia rubescens, Cortex Albiziae, (processing) Carapax Trionycis, Herba Adianti and Folium Microcoris paniculatae, add step (2) gained supernatant, soak 35 minutes, decoct with water twice, each decoction 35 minutes, filters, and merges, obtains filtrate;
(5) by step (3) gained medicinal liquid and step (4) gained filtrate mixing, be concentrated into relative density 1.15(30 DEG C) thick paste, make uniform granule, tabletting, sugar coating, make tablet.
Instructions of taking: each 2, every day 3 times, 15 days courses for the treatment of.
Test example: in order to verify the curative effect of the Chinese medicine composition (embodiment 5) that Pancreas cancer patients radiation period of the present invention is taken, We conducted contrast test.Experiment sieving Pancreas cancer patients 210 people, wherein male 116 example, women 94 example, during patient assessment, minimal ages is 34 years old, max age 77 years old, the median age 59.4 years old, wherein 45-70 year person account for 75.6%.Be divided into matched group and experimental group randomly, wherein experimental group has 150 people, and matched group has 60 people.
Experimental group: take the Chinese medicine composition that Pancreas cancer patients radiation period of the present invention is taken, each 2, every day 3 times, 15 days courses for the treatment of; Matched group: take other drug (as Kang Lixin capsule, Tegafur-uracil mixt. sheet etc.), wherein, Kang Lixin capsule: oral, a 2-3 grain, 3 times on the one; Or follow the doctor's advice.Tegafur-uracil mixt. sheet: oral, 3 times on the one, each 2-4 sheet or follow the doctor's advice.
Criterion of therapeutical effect: cure: tumor disappearance, without other transfer signs, the mental status takes a turn for the better, and check indices is normal, follows up a case by regular visits to 3 years without recurrence sign; Effective: tumor obviously reduces, the mental status is obviously improved, and check indices obviously improves; Invalid: symptom is without obvious alleviation, and check indices is not improved.Wherein effectively comprise cure and effective.
Every day same equal time, medication under square one, and observe simultaneously, record the health often organizing patient.The Comparison of therapeutic of the matched group taking other drug and the experimental group taking the Chinese medicine composition that Pancreas cancer patients radiation period of the present invention is taken, result is as shown in table 1:
Table 1
Efficacy analysis: as can be seen from Table 1, take the cure rate of the Chinese medicine composition that Pancreas cancer patients radiation period of the present invention is taken up to 68.67%, effective percentage is 95.33%, and the cure rate taking other drug only reaches 38.33%, and effective percentage is also only 73.33%.So the Chinese medicine composition that Pancreas cancer patients radiation period of the present invention is taken is compared with the medicine of other treatment cancer of pancreas, its curative effect increases substantially, and cure rate is high, inefficiency is low, evident in efficacy, greatly improving and stabilize therapeutic effect, is the another taste favourable agents for the treatment of cancer of pancreas.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. the Chinese medicine composition taken of Pancreas cancer patients radiation period, is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Semen Vaccariae 6-13 part; Herba Hyperici 8-12 part; Flame grass 5-13 part; Fructus Toosendan 4-8 part; Stigma Maydis 8-14 part; Semen Oroxyli 6-12 part; Rabdosia rubescens 7-13 part; Rhizoma phyllostachydis nigrae 9-12 part; Cortex Albiziae 5-10 part; Fructus seu semen ulmi pumilae 3-7 part; Herba Stachytarphetae Jamaicensis 5-11 part; (processing) Carapax Trionycis 4-7 part; Herba Adianti 6-11 part; Folium Microcoris paniculatae 3-10 part; Radix Bischofiae Javanicae 5-12 part.
2. Chinese medicine composition according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Semen Vaccariae 9-11 part; Herba Hyperici 9-11 part; Flame grass 8-10 part; Fructus Toosendan 5-7 part; Stigma Maydis 10-12 part; Semen Oroxyli 8-10 part; Rabdosia rubescens 9-11 part; Rhizoma phyllostachydis nigrae 10-11 part; Cortex Albiziae 7-9 part; Fructus seu semen ulmi pumilae 4-6 part; Herba Stachytarphetae Jamaicensis 7-9 part; (processing) Carapax Trionycis 5-6 part; Herba Adianti 8-10 part; Folium Microcoris paniculatae 6-8 part; Radix Bischofiae Javanicae 8-10 part.
3. Chinese medicine composition according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Semen Vaccariae 10 parts; Herba Hyperici 10 parts; Flame grass 9 parts; Fructus Toosendan 6 parts; Stigma Maydis 11 parts; Semen Oroxyli 9 parts; Rabdosia rubescens 10 parts; Rhizoma phyllostachydis nigrae 10.5 parts; Cortex Albiziae 8 parts; Fructus seu semen ulmi pumilae 5 parts; Herba Stachytarphetae Jamaicensis 8 parts; (processing) Carapax Trionycis 5.5 parts; Herba Adianti 9 parts; Folium Microcoris paniculatae 7 parts; Radix Bischofiae Javanicae 9 parts.
4., according to the preparation method of the arbitrary described Chinese medicine composition oral liquid of claim 1-3, it is characterized in that, step is as follows:
(1) Semen Vaccariae, Semen Oroxyli and Fructus seu semen ulmi pumilae are carried out microwave combustion method 15-20 minute, dry, be placed in pulverizer and pulverize, excessively 180-220 mesh sieve (preferred 190-210 mesh sieve excessively, was more preferably 220 mesh sieves);
(2) Herba Hyperici, flame grass and Herba Stachytarphetae Jamaicensis are placed in drying machine dry (preferred baking temperature is 65-75 DEG C, and being more preferably baking temperature is 70 DEG C), burn into ashes completely, add water boil 50-60 minute, leave standstill 20-30 minute, remove the impurity on surface, get supernatant, for subsequent use;
(3) Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae are smashed, be placed in container, add water (consumption of preferred water be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 2-4 doubly, the consumption being more preferably water be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 3 times), soak 3-5 hour, squeezing extracting juice, add step (1) gained medicated powder, moistening 40-60 minute, filters, obtains medicinal liquid;
(4) Stigma Maydis, Rabdosia rubescens, Cortex Albiziae, (processing) Carapax Trionycis, Herba Adianti and Folium Microcoris paniculatae are placed in marmite, add step (2) gained supernatant, soak 30-40 minute, decoct with water twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), filters, merge, obtain filtrate;
(5) by step (3) gained medicinal liquid and the mixing of step (4) gained filtrate, filter, sterile packaged.
5. preparation method according to claim 4, is characterized in that: step (1) preferably microwave combustion method frequency is 1800-2000MHz, and being more preferably microwave combustion method frequency is 1900MHz.
6., according to the preparation method of the arbitrary described Chinese medicinal composition granules of claim 1-3, it is characterized in that, step is as follows:
(1) (preferred microwave combustion method frequency is 1800-2000MHz Semen Vaccariae, Semen Oroxyli and Fructus seu semen ulmi pumilae to be carried out microwave combustion method, being more preferably microwave combustion method frequency is 1900MHz) 15-20 minute, dry, be placed in pulverizer to pulverize, cross 180-220 mesh sieve (preferred 190-210 mesh sieve excessively, was more preferably 220 mesh sieves);
(2) Herba Hyperici, flame grass and Herba Stachytarphetae Jamaicensis are placed in drying machine dry (preferred baking temperature is 65-75 DEG C, and being more preferably baking temperature is 70 DEG C), burn into ashes completely, add water boil 50-60 minute, leave standstill 20-30 minute, remove the impurity on surface, get supernatant, for subsequent use;
(3) Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae are smashed, be placed in container, add water, soak 3-5 hour, squeezing extracting juice, adds step (1) gained medicated powder, moistening 40-60 minute, filters, obtains medicinal liquid;
(4) Stigma Maydis, Rabdosia rubescens, Cortex Albiziae, (processing) Carapax Trionycis, Herba Adianti and Folium Microcoris paniculatae are placed in marmite, add step (2) gained supernatant, soak 30-40 minute, decoct with water twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), filters, merge, obtain filtrate;
(5) by step (3) gained medicinal liquid and the mixing of step (4) gained filtrate, be concentrated into the thick paste of relative density 1.10-1.20, make uniform fine particle, encapsulate with the specification of every parcel 6g.
7. preparation method according to claim 6, is characterized in that: the consumption of step (3) preferred water be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 2-4 doubly, the consumption being more preferably water be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 3 times.
8., according to the preparation method of the arbitrary described Chinese medicinal composition capsules of claim 1-3, it is characterized in that, step is as follows:
(1) (preferred microwave combustion method frequency is 1800-2000MHz Semen Vaccariae, Semen Oroxyli and Fructus seu semen ulmi pumilae to be carried out microwave combustion method, being more preferably microwave combustion method frequency is 1900MHz) 15-20 minute, dry, be placed in pulverizer to pulverize, cross 180-220 mesh sieve (preferred 190-210 mesh sieve excessively, was more preferably 220 mesh sieves);
(2) Herba Hyperici, flame grass and Herba Stachytarphetae Jamaicensis are placed in drying machine dry (preferred baking temperature is 65-75 DEG C, and being more preferably baking temperature is 70 DEG C), burn into ashes completely, add water boil 50-60 minute, leave standstill 20-30 minute, remove the impurity on surface, get supernatant, for subsequent use;
(3) Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae are smashed, be placed in container, add water (consumption of preferred water be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 2-4 doubly, the consumption being more preferably water be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 3 times), soak 3-5 hour, squeezing extracting juice, add step (1) gained medicated powder, moistening 40-60 minute, filters, obtains medicinal liquid;
(4) Stigma Maydis, Rabdosia rubescens, Cortex Albiziae, (processing) Carapax Trionycis, Herba Adianti and Folium Microcoris paniculatae are placed in marmite, add step (2) gained supernatant, soak 30-40 minute, decoct with water twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), filters, merge, obtain filtrate;
(5) by step (3) gained medicinal liquid and the mixing of step (4) gained filtrate, be concentrated into the thick paste of relative density 1.10-1.20, dry, pulverize, cross 180-220 mesh sieve;
(6) step (5) gained medicated powder is made capsule (preferably by the specification of 0.45-0.55g/ grain, being more preferably the specification by 0.5g/ grain) by the specification of 0.4-0.6g/ grain.
9., according to the preparation method of the arbitrary described Chinese medicine composition pill of claim 1-3, it is characterized in that, step is as follows:
(1) (preferred microwave combustion method frequency is 1800-2000MHz Semen Vaccariae, Semen Oroxyli and Fructus seu semen ulmi pumilae to be carried out microwave combustion method, being more preferably microwave combustion method frequency is 1900MHz) 15-20 minute, dry, be placed in pulverizer to pulverize, cross 180-220 mesh sieve (preferred 190-210 mesh sieve excessively, was more preferably 220 mesh sieves);
(2) Herba Hyperici, flame grass and Herba Stachytarphetae Jamaicensis are placed in drying machine dry (preferred baking temperature is 65-75 DEG C, and being more preferably baking temperature is 70 DEG C), burn into ashes completely, add water boil 50-60 minute, leave standstill 20-30 minute, remove the impurity on surface, get supernatant, for subsequent use;
(3) Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae are smashed, be placed in container, add water (consumption of preferred water be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 2-4 doubly, the consumption being more preferably water be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 3 times), soak 3-5 hour, squeezing extracting juice, add step (1) gained medicated powder, moistening 40-60 minute, filters, obtains medicinal liquid;
(4) Stigma Maydis, Rabdosia rubescens, Cortex Albiziae, (processing) Carapax Trionycis, Herba Adianti and Folium Microcoris paniculatae are placed in marmite, add step (2) gained supernatant, soak 30-40 minute, decoct with water twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), filters, merge, obtain filtrate;
(5) by step (3) gained medicinal liquid and the mixing of step (4) gained filtrate, be concentrated into the thick paste of relative density 1.10-1.20, dry, pulverize, cross 120-140 mesh sieve;
(6) by Mel, (consumption of preferred Mel is the 10%-20% of medicated powder quality, the consumption being more preferably Mel is 15% of medicated powder quality) be placed in pot, temper with slow fire, endure to thick Deng Mel, mix step (5) gained medicated powder again, fully mix into ointment thoroughly, (preferred diameter is 3-5mm to make pill, being more preferably diameter is 4mm), obtain pill.
10., according to the preparation method of the arbitrary described Chinese medicine composition tablet of claim 1-3, it is characterized in that, step is as follows:
(1) (preferred microwave combustion method frequency is 1800-2000MHz Semen Vaccariae, Semen Oroxyli and Fructus seu semen ulmi pumilae to be carried out microwave combustion method, being more preferably microwave combustion method frequency is 1900MHz) 15-20 minute, dry, be placed in pulverizer to pulverize, cross 180-220 mesh sieve (preferred 190-210 mesh sieve excessively, was more preferably 220 mesh sieves);
(2) Herba Hyperici, flame grass and Herba Stachytarphetae Jamaicensis are placed in drying machine dry (preferred baking temperature is 65-75 DEG C, and being more preferably baking temperature is 70 DEG C), burn into ashes completely, add water boil 50-60 minute, leave standstill 20-30 minute, remove the impurity on surface, get supernatant, for subsequent use;
(3) Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae are smashed, be placed in container, add water (consumption of preferred water be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 2-4 doubly, the consumption being more preferably water be Fructus Toosendan, Rhizoma phyllostachydis nigrae and Radix Bischofiae Javanicae quality 3 times), soak 3-5 hour, squeezing extracting juice, add step (1) gained medicated powder, moistening 40-60 minute, filters, obtains medicinal liquid;
(4) Stigma Maydis, Rabdosia rubescens, Cortex Albiziae, (processing) Carapax Trionycis, Herba Adianti and Folium Microcoris paniculatae are placed in marmite, add step (2) gained supernatant, soak 30-40 minute, decoct with water twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), filters, merge, obtain filtrate;
(5) by step (3) gained medicinal liquid and the mixing of step (4) gained filtrate, be concentrated into the thick paste of relative density 1.10-1.20, make uniform granule, tabletting, sugar coating, make tablet.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1491671A (en) * | 2002-06-26 | 2004-04-28 | 李健勇 | Medicinal composition for treating liver cancer and pancreatic cancer and its preparing method |
| CN101209263A (en) * | 2006-12-26 | 2008-07-02 | 朴贞子 | Medicine for treating tumor |
| CN101632756A (en) * | 2008-07-24 | 2010-01-27 | 张国政 | Traditional Chinese medicine for treating malignant tumours and preparation method thereof |
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2016
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1491671A (en) * | 2002-06-26 | 2004-04-28 | 李健勇 | Medicinal composition for treating liver cancer and pancreatic cancer and its preparing method |
| CN101209263A (en) * | 2006-12-26 | 2008-07-02 | 朴贞子 | Medicine for treating tumor |
| CN101632756A (en) * | 2008-07-24 | 2010-01-27 | 张国政 | Traditional Chinese medicine for treating malignant tumours and preparation method thereof |
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Address after: 545000 the Guangxi Zhuang Autonomous Region road Liunan District Liuzhou City Lake in Hexi District 2 building 1-1001 Applicant after: Chen Xicheng Address before: 250014 Shandong Province, Lixia District of Ji'nan city jiangshuiquan Road No. 1 jichai nine dormitory 2 floor 1 unit 201 Applicant before: Chen Xicheng |
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