CN105532739A - Antimicrobial composition with excellent biocompatibility - Google Patents
Antimicrobial composition with excellent biocompatibility Download PDFInfo
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- CN105532739A CN105532739A CN201610000293.2A CN201610000293A CN105532739A CN 105532739 A CN105532739 A CN 105532739A CN 201610000293 A CN201610000293 A CN 201610000293A CN 105532739 A CN105532739 A CN 105532739A
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- antimicrobial compositions
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/10—Animals; Substances produced thereby or obtained therefrom
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/10—Aromatic or araliphatic carboxylic acids, or thio analogues thereof; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses an antimicrobial composition with excellent biocompatibility. The antimicrobial composition is prepared from, by weight, 30-38 parts of ethyl alcohol, 28-32 parts of ethylene glycol, 28-32 parts of propylene glycol, 20-28 parts of 6-aminopenicillanicacid, 20-28 parts of hydroxybenzene, 10-18 parts of benzoic acid, 10-18 parts of propionic acid and 4-6 parts of streptococcus lactis peptide. A preparation method of the antimicrobial composition comprises the steps that S1, ethyl alcohol, ethylene glycol and propylene glycol are weighed by ratio and subjected to a mixed reaction at the temperature of 30-40 DEG C for 1-2 hours to obtain a reactant A; S2, 6-aminopenicillanicacid, hydroxybenzene, benzoic acid and propionic acid are weighed by ratio, added into the reactant A in sequence and mixed with the reactant A for 2-3 hours to obtain a mixture B; S3, streptococcus lactis peptide is weighed by ratio and added into the mixture B three times. The preparation method is simple, and the prepared antimicrobial composition is good in biocompatibility and suitable for popularization.
Description
Technical field
The present invention relates to antimicrobial compositions technical field, particularly relate to a kind of antimicrobial compositions with superior bio compatibility.
Background technology
Microorganism, comprises a large class biocenose of bacterium, virus, fungi and some small-sized protozoas etc., individual small, closely related with human lives.Relate generally to the numerous areas such as health, medicine, industrial or agricultural, environmental protection.In the textbook of CONTINENTAL AREA OF CHINA, all microorganism is divided into following 8 large classes: bacterium, virus, fungi, actinomycetes, Richettsia, mycoplasma, Chlamydia, conveyor screw.
Existing antimicrobial compositions is good not on biocompatibility, not satisfactory for antimicrobial effect, we have proposed a kind of antimicrobial compositions with superior bio compatibility for this reason.
Summary of the invention
Based on the technical problem that background technology exists, the present invention proposes a kind of antimicrobial compositions with superior bio compatibility.
A kind of antimicrobial compositions with superior bio compatibility that the present invention proposes, comprises the raw material of following weight portion: ethanol 30-38 part, ethylene glycol 28-32 part, propane diols 28-32 part, 6-amino-penicillanic acid 20-28 part, hydroxy benzenes 20-28 part, benzoic acid 10-18 part, propionic acid 10-18 part, nisin 4-6 part;
Its preparation method comprises the following steps:
S1, takes ethanol, ethylene glycol, propane diols according to deal proportioning, by above-mentioned raw materials hybrid reaction at the temperature of 30-40 DEG C, continues 1-2h, obtains reactant A;
S2, takes 6-amino-penicillanic acid, hydroxy benzenes, benzoic acid, propionic acid according to deal proportioning, above-mentioned raw materials is put into reactant A successively, mix, and continues 2-3h, obtains mixture B;
S3, takes nisin according to deal proportioning, is divided by nisin and joins for three times in mixture B, can obtain a kind of antimicrobial compositions with superior bio compatibility after reaction 1-3h.
Preferably, the pH of described antimicrobial compositions is 4-8.
Preferably, the pH of described antimicrobial compositions is 6-7.
Preferably, described antimicrobial compositions comprises the raw material of following weight portion: ethanol 32-36 part, ethylene glycol 29-31 part, propane diols 29-31 part, 6-amino-penicillanic acid 22-26 part, hydroxy benzenes 22-26 part, benzoic acid 12-16 part, propionic acid 12-16 part, nisin 4.5-5.5 part.
Preferably, described antimicrobial compositions comprises the raw material of following weight portion: ethanol 34 parts, ethylene glycol 30 parts, propane diols 30 parts, 6-amino-penicillanic acid 24 parts, hydroxy benzenes 24 parts, 14 parts, benzoic acid, propionic acid 14 parts, nisin 5 parts.
Preferably, the weight ratio of described ethanol, ethylene glycol, propane diols is 32-36:29-31:29-31.
Preferably, described 6-amino-penicillanic acid, hydroxy benzenes, benzoic weight ratio are 22-26:22-26:12-16.
Preferably, the weight ratio of described propionic acid, nisin is 12-16:4.5-5.5.
In the present invention, choose the good raw materials of compatibility such as ethanol, ethylene glycol, propane diols to mix, be conducive to the raw material adding other in the later stage, simple and convenient, 6-amino-penicillanic acid, hydroxy benzenes, benzoic acid, propionic acid in adding again afterwards, by reaction mutual between raw material, change chemical property wherein, can greatly improve antimicrobial effect, finally add nisin and improve the effect suppressing microorganism further, preparation method of the present invention is simple, and the antimicrobial compositions biocompatibility prepared is good, is applicable to promoting.
Embodiment
Below in conjunction with specific embodiment, further explanation is done to the present invention.
Embodiment one
A kind of antimicrobial compositions with superior bio compatibility that the present invention proposes, comprises the raw material of following weight portion: ethanol 30 parts, ethylene glycol 28 parts, propane diols 28 parts, 6-amino-penicillanic acid 20 parts, hydroxy benzenes 20 parts, 10 parts, benzoic acid, propionic acid 10 parts, nisin 4 parts;
Its preparation method comprises the following steps:
S1, takes ethanol, ethylene glycol, propane diols according to deal proportioning, by above-mentioned raw materials hybrid reaction at the temperature of 30 DEG C, continues 1h, obtains reactant A;
S2, takes 6-amino-penicillanic acid, hydroxy benzenes, benzoic acid, propionic acid according to deal proportioning, above-mentioned raw materials is put into reactant A successively, mix, and continues 2h, obtains mixture B;
S3, takes nisin according to deal proportioning, is divided by nisin and joins for three times in mixture B, can obtain a kind of antimicrobial compositions with superior bio compatibility after reaction 1h.
Embodiment two
A kind of antimicrobial compositions with superior bio compatibility that the present invention proposes, comprises the raw material of following weight portion: ethanol 32 parts, ethylene glycol 29 parts, propane diols 29 parts, 6-amino-penicillanic acid 22 parts, hydroxy benzenes 22 parts, 12 parts, benzoic acid, propionic acid 12 parts, nisin 4.5 parts;
Its preparation method comprises the following steps:
S1, takes ethanol, ethylene glycol, propane diols according to deal proportioning, by above-mentioned raw materials hybrid reaction at the temperature of 32.5 DEG C, continues 1.25h, obtains reactant A;
S2, takes 6-amino-penicillanic acid, hydroxy benzenes, benzoic acid, propionic acid according to deal proportioning, above-mentioned raw materials is put into reactant A successively, mix, and continues 2.25h, obtains mixture B;
S3, takes nisin according to deal proportioning, is divided by nisin and joins for three times in mixture B, can obtain a kind of antimicrobial compositions with superior bio compatibility after reaction 1.5h.
Embodiment three
A kind of antimicrobial compositions with superior bio compatibility that the present invention proposes, comprises the raw material of following weight portion: ethanol 34 parts, ethylene glycol 30 parts, propane diols 30 parts, 6-amino-penicillanic acid 24 parts, hydroxy benzenes 24 parts, 14 parts, benzoic acid, propionic acid 14 parts, nisin 5 parts;
Its preparation method comprises the following steps:
S1, takes ethanol, ethylene glycol, propane diols according to deal proportioning, by above-mentioned raw materials hybrid reaction at the temperature of 35 DEG C, continues 1.5h, obtains reactant A;
S2, takes 6-amino-penicillanic acid, hydroxy benzenes, benzoic acid, propionic acid according to deal proportioning, above-mentioned raw materials is put into reactant A successively, mix, and continues 2.5h, obtains mixture B;
S3, takes nisin according to deal proportioning, is divided by nisin and joins for three times in mixture B, can obtain a kind of antimicrobial compositions with superior bio compatibility after reaction 2h.
Embodiment four
A kind of antimicrobial compositions with superior bio compatibility that the present invention proposes, comprises the raw material of following weight portion: ethanol 36 parts, ethylene glycol 31 parts, propane diols 31 parts, 6-amino-penicillanic acid 26 parts, hydroxy benzenes 26 parts, 16 parts, benzoic acid, propionic acid 16 parts, nisin 5.5 parts;
Its preparation method comprises the following steps:
S1, takes ethanol, ethylene glycol, propane diols according to deal proportioning, by above-mentioned raw materials hybrid reaction at the temperature of 37.5 DEG C, continues 1.75h, obtains reactant A;
S2, takes 6-amino-penicillanic acid, hydroxy benzenes, benzoic acid, propionic acid according to deal proportioning, above-mentioned raw materials is put into reactant A successively, mix, and continues 2.75h, obtains mixture B;
S3, takes nisin according to deal proportioning, is divided by nisin and joins for three times in mixture B, can obtain a kind of antimicrobial compositions with superior bio compatibility after reaction 2.5h.
Embodiment five
A kind of antimicrobial compositions with superior bio compatibility that the present invention proposes, comprises the raw material of following weight portion: ethanol 38 parts, ethylene glycol 32 parts, propane diols 32 parts, 6-amino-penicillanic acid 28 parts, hydroxy benzenes 28 parts, 18 parts, benzoic acid, propionic acid 18 parts, nisin 6 parts;
Its preparation method comprises the following steps:
S1, takes ethanol, ethylene glycol, propane diols according to deal proportioning, by above-mentioned raw materials hybrid reaction at the temperature of 40 DEG C, continues 2h, obtains reactant A;
S2, takes 6-amino-penicillanic acid, hydroxy benzenes, benzoic acid, propionic acid according to deal proportioning, above-mentioned raw materials is put into reactant A successively, mix, and continues 3h, obtains mixture B;
S3, takes nisin according to deal proportioning, is divided by nisin and joins for three times in mixture B, can obtain a kind of antimicrobial compositions with superior bio compatibility after reaction 3h.
The above; be only the present invention's preferably embodiment; but protection scope of the present invention is not limited thereto; anyly be familiar with those skilled in the art in the technical scope that the present invention discloses; be equal to according to technical scheme of the present invention and inventive concept thereof and replace or change, all should be encompassed within protection scope of the present invention.
Claims (8)
1. one kind has the antimicrobial compositions of superior bio compatibility, it is characterized in that, comprise the raw material of following weight portion: ethanol 30-38 part, ethylene glycol 28-32 part, propane diols 28-32 part, 6-amino-penicillanic acid 20-28 part, hydroxy benzenes 20-28 part, benzoic acid 10-18 part, propionic acid 10-18 part, nisin 4-6 part;
Its preparation method comprises the following steps:
S1, takes ethanol, ethylene glycol, propane diols according to deal proportioning, by above-mentioned raw materials hybrid reaction at the temperature of 30-40 DEG C, continues 1-2h, obtains reactant A;
S2, takes 6-amino-penicillanic acid, hydroxy benzenes, benzoic acid, propionic acid according to deal proportioning, above-mentioned raw materials is put into reactant A successively, mix, and continues 2-3h, obtains mixture B;
S3, takes nisin according to deal proportioning, is divided by nisin and joins for three times in mixture B, can obtain a kind of antimicrobial compositions with superior bio compatibility after reaction 1-3h.
2. a kind of antimicrobial compositions with superior bio compatibility according to claim 1, is characterized in that, the pH of described antimicrobial compositions is 4-8.
3. a kind of antimicrobial compositions with superior bio compatibility according to claim 1 and 2, is characterized in that, the pH of described antimicrobial compositions is 6-7.
4. a kind of antimicrobial compositions with superior bio compatibility according to claim 1, it is characterized in that, described antimicrobial compositions comprises the raw material of following weight portion: ethanol 32-36 part, ethylene glycol 29-31 part, propane diols 29-31 part, 6-amino-penicillanic acid 22-26 part, hydroxy benzenes 22-26 part, benzoic acid 12-16 part, propionic acid 12-16 part, nisin 4.5-5.5 part.
5. a kind of antimicrobial compositions with superior bio compatibility according to claim 1, it is characterized in that, described antimicrobial compositions comprises the raw material of following weight portion: ethanol 34 parts, ethylene glycol 30 parts, propane diols 30 parts, 6-amino-penicillanic acid 24 parts, hydroxy benzenes 24 parts, 14 parts, benzoic acid, propionic acid 14 parts, nisin 5 parts.
6. a kind of antimicrobial compositions with superior bio compatibility according to claim 1, is characterized in that, the weight ratio of described ethanol, ethylene glycol, propane diols is 32-36:29-31:29-31.
7. a kind of antimicrobial compositions with superior bio compatibility according to claim 1, is characterized in that, described 6-amino-penicillanic acid, hydroxy benzenes, benzoic weight ratio are 22-26:22-26:12-16.
8. a kind of antimicrobial compositions with superior bio compatibility according to claim 1, is characterized in that, the weight ratio of described propionic acid, nisin is 12-16:4.5-5.5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610000293.2A CN105532739A (en) | 2016-01-03 | 2016-01-03 | Antimicrobial composition with excellent biocompatibility |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610000293.2A CN105532739A (en) | 2016-01-03 | 2016-01-03 | Antimicrobial composition with excellent biocompatibility |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101933521A (en) * | 2009-07-01 | 2011-01-05 | 李新建 | Preparation and application thereof of sterilization composition |
| CN102090413A (en) * | 2010-12-22 | 2011-06-15 | 李新建 | Preparation and application of compound disinfectant |
| CN104546522A (en) * | 2014-12-18 | 2015-04-29 | 广东雅威生物科技有限公司 | Composition with high-efficiency broad-spectrum antibacterial capacity and application of composition in cosmetics |
| CN105025712A (en) * | 2013-03-08 | 2015-11-04 | 西姆莱斯股份公司 | Antimicrobial compositions |
-
2016
- 2016-01-03 CN CN201610000293.2A patent/CN105532739A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101933521A (en) * | 2009-07-01 | 2011-01-05 | 李新建 | Preparation and application thereof of sterilization composition |
| CN102090413A (en) * | 2010-12-22 | 2011-06-15 | 李新建 | Preparation and application of compound disinfectant |
| CN105025712A (en) * | 2013-03-08 | 2015-11-04 | 西姆莱斯股份公司 | Antimicrobial compositions |
| CN104546522A (en) * | 2014-12-18 | 2015-04-29 | 广东雅威生物科技有限公司 | Composition with high-efficiency broad-spectrum antibacterial capacity and application of composition in cosmetics |
Non-Patent Citations (3)
| Title |
|---|
| 揭晶: "《药物分析检测技术》", 28 February 2014 * |
| 江汉湖: "《食品微生物学》", 31 August 2002 * |
| 谭洪治: "《微生物学》", 31 October 1988 * |
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Application publication date: 20160504 |