CN104546522A - Composition with high-efficiency broad-spectrum antibacterial capacity and application of composition in cosmetics - Google Patents
Composition with high-efficiency broad-spectrum antibacterial capacity and application of composition in cosmetics Download PDFInfo
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- CN104546522A CN104546522A CN201410783672.4A CN201410783672A CN104546522A CN 104546522 A CN104546522 A CN 104546522A CN 201410783672 A CN201410783672 A CN 201410783672A CN 104546522 A CN104546522 A CN 104546522A
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Abstract
The invention provides a composition with high-efficiency broad-spectrum antibacterial capacity. The composition is prepared by the following steps: mixing the following components in percentage by weight: 10-40 percent of hydroxyacetophenone, 5-30 percent of glycerol caprylate and 30-60 percent of C2-10 dihydric alcohol, heating to the temperature of 80-90 DEG C, completely dissolving the materials, thereby obtaining the product. According to the composition disclosed by the invention, Gram negative bacteria, gram-positive bacteria, moulds and saccharomycetes thereof in the cosmetics can be effectively inhibited and killed under the conditions of low addition amount, high safety, mildness and low irritation, and the composition has certain effects of moisturizing, assisting emulsification and resisting oxidation and is particularly suitable to serve as a preservative in the transparent system, W/O or O/W cream emulsification system and surfactant washing system. The invention also provides an application of the composition serving as a preservative in the cosmetics.
Description
Technical field
The present invention relates to a kind of compositions, particularly relate to a kind of compositions antibacterial and fungus to inhibitory or killing effect, more specifically relate to a kind of compositions with high-efficiency broad spectrum bacteriostasis.The invention still further relates to the application of this compositions in cosmetics.
Background technology
Owing to the addition of a large number of nutrients in cosmetics, easily for the breeding of microorganism creates conditions, therefore, in the production of cosmetics, circulation and consumer's use procedure, easy generation microbial spoilage, this corruption not only damages the performance of product, and also can produce health hazard to user in extreme situations, therefore, the anticorrosion problem being cosmetics quality and ensureing to need to solve.The anti-corrosion method of cosmetics comprises physical method and chemical method, and physical method is generally adopt heat sterilization or radiation sterilization, and chemical method adopts to add antiseptic in cosmetics; Because heat sterilization is not suitable for the cosmetics that low temperature process produces, and the requirement of radiation sterilization to equipment is high, therefore, add in cosmetics antiseptic be resist microorganism to the pollution of cosmetics, improve cosmetics quality and the main method of shelf-life.
The traditional preservatives being suitable for cosmetics interpolation mainly contains several as follows, but find that they all exist problem more or less: (1) parabens, be most widely used with long, its shortcoming is that such material can permeate and be accumulated in generation stimulation in tissue, in the section of breast carcinoma, now find that there is such material remain, therefore, European Union's suggestion forbidding or the cosmetics that limit the use of containing parabens; (2) formaldehyde and Form aldehyde release body thereof, its shortcoming there is potential carcinogenecity; (3) isothiazolinone, its shortcoming there is zest and sensitization, and European Union's suggestion is forbidden using isothiazolinone antiseptic in anelasticity cosmetics; (4) organic halogen composition, its shortcoming there is potential sensitization; (5) organic acid and its esters, its shortcoming is that antiseptic effect is weak, and zest is large; (6) Bronopol, may generate nitrosamine, have carcinogenic toxicity.Along with improving constantly of people's living standard, to quality, the safety also pay attention to day by day of cosmetics, therefore, find one safely, have no side effect, and having the aseptic production of broad-spectrum antibacterial ability, is the problem that those skilled in the art endeavour to solve.
Summary of the invention
For solving above Problems existing, the object of this invention is to provide a kind of compositions with high-efficiency broad spectrum bacteriostasis, said composition gentleness is non-stimulated, with moisturizing, the characteristic helping emulsifying, antioxidation etc.
Another object of the present invention is to provide the application of a kind of above-mentioned composition in cosmetics.
For realizing above object, the compositions with high-efficiency broad spectrum bacteriostasis of the present invention is by comprising the C that components by weight percent is the hydroxy acetophenone of 10-40%, the glycerol caprylate of 5-30% and 30-60%
2-10dihydroxylic alcohols through mixing post-heating dissolve acquisition completely to 80-90 DEG C.
The preferred parahydroxyacet-ophenone of above-mentioned hydroxy acetophenone.
Above-mentioned C
2-10dihydroxylic alcohols preferably 1,2-hexanediol, ethylene glycol, 1,2-PD, 1,3-PD or 1,3 butylene glycol, 1,2-pentanediol, 1,2-ethohexadiol or 1,2-certain herbaceous plants with big flowers glycol.
In order to promote that parahydroxyacet-ophenone and glycerol caprylate penetrate in the cell of microorganism better, above-mentioned C
2-10dihydroxylic alcohols preferably 1,2-hexanediol.
In order to increase the water solubility of compositions, transparent water preparation is formed to add in aqueous solution, above-mentioned composition also comprises the solubilizing agent that components by weight percent is 5-15%, one or more in the preferred Cremophor RH40 of this solubilizing agent, polysorbate-20 or polysorbate-40.
But kill ability in order to better improve compositions in mycete, above-mentioned composition also can add the traditional preservatives that components by weight percent is 0.1-3%, this traditional preservatives preferred iodine propilolic alcohol butyl mephenesin Carbamate, chlorobenzene glycosides ether, parabens or formaldehyde sustained release.
The above-mentioned compositions with high-efficiency broad spectrum bacteriostasis in cosmetics preparation as the application of antiseptic.
The addition of above-mentioned composition in cosmetics is 0.5-5.0%, and the pH scope of application of compositions in cosmetics is 2-12.
The addition of above-mentioned composition in cosmetics preferably 0.5-1.0%, the pH scope of application of compositions in cosmetics preferably 3-8.
For preventing hydroxy acetophenone from losing activity after being heated for a long time, above-mentioned composition in cosmetics be heated tolerance band preferably 90 DEG C be no more than 2 hours, 60 DEG C are no more than 5 hours.
The compositions with high-efficiency broad spectrum bacteriostasis of the present invention, by selecting certain proportioning and being suitable for hydroxy acetophenone that cosmetics use, glycerol caprylate and C
2-10dihydroxylic alcohols, the synergistic function utilizing the original characteristic of each component and have each other, but make that the compositions of acquisition is low at addition, safety is high, the gram negative bacteria that can not only effectively kill under the prerequisite of mild low-stimulation in cosmetics, gram positive bacteria, mycete and yeast thereof, and there is certain moisturizing, help emulsifying, effect of antioxidation; Compositions good water solubility of the present invention, directly can add in aqueous phase under room temperature or hot conditions, also can add after system emulsifying when doing w/o emulsion, cream frost, might as well with the compatibility of large absolutely number cosmetic material, its bacteriostasis is not by the impact of surfactant, protein, chelating agen and the plant extract thereof in cosmetic material, be particularly suitable as transparent system, the antiseptic of W/O or O/W cream frost emulsification system and surfactant wash system uses.
Detailed description of the invention
Below by specific embodiment, technical scheme of the present invention is described further; but these embodiments are not for limiting the scope of the invention; under the prerequisite not departing from theory of the present invention; to the equivalent replacement of each component or the adjustment of each component proportion, protection scope of the present invention all should be belonged to.
(1) product example
Embodiment 1
1, composite formula
2, prepare
Above-mentioned each component is placed in the reactor with agitating device, after being uniformly mixed, being heated to 85 DEG C, being stirred to and dissolving completely, be cooled to room temperature, the pH value of water solution obtaining 10% be 3.8 faint yellow to yellow transparent liquid.
3, product minimum inhibitory concentration (MIC)
Embodiment 2
1, composite formula
2, prepare
Above-mentioned each component is placed in the reactor with agitating device, after being uniformly mixed, being heated to 80 DEG C, being stirred to and dissolving completely, be cooled to room temperature, the pH value of water solution obtaining 10% be 3.6 faint yellow to yellow transparent liquid.
3, the minimum inhibitory concentration (MIC) of product
Embodiment 3
1, composite formula
2, prepare
Above-mentioned each component is placed in the reactor with agitating device, after being uniformly mixed, being heated to 90 DEG C, being stirred to and dissolving completely, be cooled to room temperature, the pH value of water solution obtaining 10% be 3.7 faint yellow to yellow transparent liquid.
3, product minimum inhibitory concentration (MIC)
(2) application example
1, transparent aqueous solution application
(1) transparent aqueous solution formula
The product obtained by above-described embodiment 1-3 adds in transparent aqueous solution as antiseptic, and formula is as follows:
(2) transparent aqueous solution preparation
A, A phase to be added by each component ratio, be heated to 80 DEG C, be stirred to and dissolve completely;
B, when solution is down to 40-50 DEG C, B is added in A phase, stirs.
(3) contrast experiment
Corresponding facial film is made, according to ASTM E640-2006(2012 by not adding antiseptic and being added with the transparent aqueous solution that embodiment 1-3 obtains product) method of testing of antiseptic " in the aqueous cosmetics ", carry out preservation challenge test, result is as follows:
Add embodiment 1 product
Add embodiment 2 product
Add embodiment 3 product
Remarks: 1, in table, " < 10 " represents that this dilution factor does not detect bacterium;
2, result judges: antibacterial at least reduced 99.9% within seven days, and tests not increase in 7-28 days; Mycete should at least 90% within seven days, and tests in 7-28 days and do not increase.
Result judges: antibacterial at least reduced 99.9% within seven days, and tests not increase in 7-28 days; Mycete should at least 90% within seven days, and tests in 7-28 days and do not increase.
3,
attached test microbes strain:
Antibacterial: Pseudomonas aeruginosa (Pseudomonas aerugimosa) ATCC 9027
Colon bacillus (Escherichia coli) ATCC 8739
Staphylococcus aureus (Staphylococcus aureus) ATCC 6538
Burkholderia (Burkholderia cepacia) ATCC 25416
Day ditch dimension enterobacteria (Enterobacter gergoviae) ATCC 33028
Mycete: candida albicans (Candida albicans) ATCC 10231
Aspergillus niger (Aspergillus niger) ATCC 16404
Level and smooth penicillium (Eupenicillium levitum) ATCC10464
As can be seen from above-mentioned test result, contrast blank facial mask liquid, add the facial mask liquid of the present composition, antibacterial and mycete all decreased 4 orders of magnitude (99.99%) in 7 days, loseed growth in 28 days.
2, milky lotion application
(1) milky lotion formula
The product obtained by above-described embodiment 1-3 adds in milky lotion as antiseptic, and formula is as follows:
(2) milky lotion preparation
A, each for A phase component is added in proportion after, be heated to 70 DEG C and dissolve completely, stir, stand-by;
B, by carbomer in B phase first swelling completely in water after, stand-by;
C, each for C phase component is added in proportion after, be heated to 70 DEG C and dissolve completely, stir, stand-by;
D, be added in C phase by B, stir, be then added to wherein by A, homogenizing stirs;
E, be cooled to 40-50 DEG C, each for D phase component added in above-mentioned emulsion, stirs.
(3) contrast experiment
To not add antiseptic and be added with the milky lotion that embodiment 1 obtains product, according to ASTM
E640-2006(2012) method of testing of antiseptic " in the aqueous cosmetics ", carry out preservation challenge test, result is as follows:
As can be seen from above-mentioned test result, contrast blank milky lotion, add the milky lotion of the present composition, antibacterial and mycete all decreased 4 orders of magnitude (99.99%) in 7 days, loseed growth in 28 days.
Compositions of the present invention is made up of the multi-functional component had antibacterial and the splendid fungistatic effect of fungus, although traditional preservatives and antibacterial can be added press down fungicidal ability better to improve it, but the addition of traditional preservatives and antibacterial extremely small (content in cosmetics is about 0.0005%-0.03%), for supporting the compound system of " without adding antiseptic " concept completely in cosmetics.
Claims (10)
1. there is a compositions for high-efficiency broad spectrum bacteriostasis, it is characterized in that: described compositions is by comprising the C that components by weight percent is the hydroxy acetophenone of 10-40%, the glycerol caprylate of 5-30% and 30-60%
2-10dihydroxylic alcohols through mixing post-heating dissolve acquisition completely to 80-90 DEG C.
2. the compositions with high-efficiency broad spectrum bacteriostasis according to claim 1, is characterized in that: described hydroxy acetophenone is parahydroxyacet-ophenone.
3. the compositions with high-efficiency broad spectrum bacteriostasis according to claim 2, is characterized in that: described C
2-10dihydroxylic alcohols be 1,2-hexanediol, ethylene glycol, 1,2-PD, 1,3-PD or 1,3 butylene glycol, 1,2-pentanediol, 1,2-ethohexadiol, 1,2-nonanediol or 1,2-certain herbaceous plants with big flowers glycol.
4. the compositions with high-efficiency broad spectrum bacteriostasis according to claim 3, is characterized in that: described C
2-10dihydroxylic alcohols be 1,2-hexanediol.
5. the compositions with high-efficiency broad spectrum bacteriostasis according to claim 4, it is characterized in that: described compositions also comprises the solubilizing agent that components by weight percent is 5-15%, this solubilizing agent is one or more in Cremophor RH40, polysorbate-20 or polysorbate-40, Polyethylene Glycol-50/400/1000.
6. the compositions with high-efficiency broad spectrum bacteriostasis according to claim 5, it is characterized in that: described compositions also can add the traditional preservatives that components by weight percent is 0.1-3%, this traditional preservatives preferred iodine propilolic alcohol butyl mephenesin Carbamate, chlorobenzene glycosides ether, parabens or formaldehyde sustained release.
7. arbitrary compositions with high-efficiency broad spectrum bacteriostasis described in a claim 1-6 in cosmetics preparation as the application of antiseptic.
8. the compositions according to claim 7 with high-efficiency broad spectrum bacteriostasis in cosmetics preparation as the application of antiseptic, it is characterized in that: the addition of described compositions in cosmetics is 0.5-5.0%, the pH scope of application of compositions in cosmetics is 2-1.
9. the compositions according to claim 8 with high-efficiency broad spectrum bacteriostasis in cosmetics preparation as the application of antiseptic, it is characterized in that: the addition of described compositions in cosmetics is 0.5-1.0%, the pH scope of application of compositions in cosmetics is 3-8.
10. the compositions according to claim 9 with high-efficiency broad spectrum bacteriostasis in cosmetics preparation as the application of antiseptic, it is characterized in that: the be heated tolerance band of described compositions in cosmetics is 90 DEG C and is no more than 2 hours, and 60 DEG C are no more than 5 hours.
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| CN201410783672.4A CN104546522A (en) | 2014-12-18 | 2014-12-18 | Composition with high-efficiency broad-spectrum antibacterial capacity and application of composition in cosmetics |
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| CN201410783672.4A CN104546522A (en) | 2014-12-18 | 2014-12-18 | Composition with high-efficiency broad-spectrum antibacterial capacity and application of composition in cosmetics |
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| CN105532739A (en) * | 2016-01-03 | 2016-05-04 | 安徽律正科技信息服务有限公司 | Antimicrobial composition with excellent biocompatibility |
| CN106176480A (en) * | 2016-08-30 | 2016-12-07 | 广州品赫化妆品有限公司 | A kind of food grade compositions with antiseptic activity and the application in cosmetics thereof |
| CN106511120A (en) * | 2015-09-10 | 2017-03-22 | 上海春露生物化学有限公司 | Composition having corrosion preventing function as well as preparation and application of composition |
| WO2017093428A1 (en) * | 2015-12-04 | 2017-06-08 | Henkel Ag & Co. Kgaa | Use of additives for effective preservation/boost effect of existing preservation of cosmetic emulsions |
| CN107184406A (en) * | 2017-05-11 | 2017-09-22 | 曾万祥 | One kind is planted extraction without anti-corrosion ginger without silicone oil shampoo and preparation method thereof |
| CN107184413A (en) * | 2017-05-11 | 2017-09-22 | 曾万祥 | It is a kind of to repair moist hair film of root of hair and preparation method thereof without anti-corrosion depth |
| CN107233249A (en) * | 2017-06-14 | 2017-10-10 | 曾万祥 | Plant extraction for one kind and nourish shower cream and preparation method thereof |
| CN107375053A (en) * | 2017-06-16 | 2017-11-24 | 曾万祥 | A kind of ginseng and Chinese angelica root is without silicone oil shampoo and preparation method thereof |
| CN107375063A (en) * | 2017-07-14 | 2017-11-24 | 曾万祥 | A kind of shower cream and preparation method |
| CN107432834A (en) * | 2017-07-19 | 2017-12-05 | 广州市皓雨化妆品有限公司 | It is a kind of with fungistatic effect without anti-corrosion composition composition and its preparation method and application |
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| CN107624758A (en) * | 2017-10-17 | 2018-01-26 | 北京桑普生物化学技术有限公司 | A kind of complex composition containing parahydroxyacet-ophenone and preparation method and application |
| CN107669543A (en) * | 2017-10-11 | 2018-02-09 | 广州市禾基生物科技有限公司 | A kind of preservative and preparation method thereof |
| CN108113908A (en) * | 2018-03-02 | 2018-06-05 | 深圳市澳妆生物科技研究所有限公司 | Lemon grass (Cymbopogon citratus) plants extraction bath elite dew |
| CN111568822A (en) * | 2020-04-14 | 2020-08-25 | 广东润洁日化有限公司 | Compound preservative composition without preservative for cosmetics |
| WO2022093257A1 (en) * | 2020-10-30 | 2022-05-05 | Kimberly-Clark Worldwide, Inc. | Stable antimicrobial formulation concentrate |
| EP4085766A1 (en) * | 2021-05-03 | 2022-11-09 | Minagro Srl | Use of 1,2-alkanediols as adjuvant in agriculture |
| CN115463043A (en) * | 2022-08-25 | 2022-12-13 | 克劳丽化妆品股份有限公司 | Oral care composition and mouthwash |
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| CN106511120A (en) * | 2015-09-10 | 2017-03-22 | 上海春露生物化学有限公司 | Composition having corrosion preventing function as well as preparation and application of composition |
| WO2017093428A1 (en) * | 2015-12-04 | 2017-06-08 | Henkel Ag & Co. Kgaa | Use of additives for effective preservation/boost effect of existing preservation of cosmetic emulsions |
| CN105532739A (en) * | 2016-01-03 | 2016-05-04 | 安徽律正科技信息服务有限公司 | Antimicrobial composition with excellent biocompatibility |
| CN106176480A (en) * | 2016-08-30 | 2016-12-07 | 广州品赫化妆品有限公司 | A kind of food grade compositions with antiseptic activity and the application in cosmetics thereof |
| CN107184406A (en) * | 2017-05-11 | 2017-09-22 | 曾万祥 | One kind is planted extraction without anti-corrosion ginger without silicone oil shampoo and preparation method thereof |
| CN107184413A (en) * | 2017-05-11 | 2017-09-22 | 曾万祥 | It is a kind of to repair moist hair film of root of hair and preparation method thereof without anti-corrosion depth |
| CN107233249A (en) * | 2017-06-14 | 2017-10-10 | 曾万祥 | Plant extraction for one kind and nourish shower cream and preparation method thereof |
| CN107375053A (en) * | 2017-06-16 | 2017-11-24 | 曾万祥 | A kind of ginseng and Chinese angelica root is without silicone oil shampoo and preparation method thereof |
| CN107375063A (en) * | 2017-07-14 | 2017-11-24 | 曾万祥 | A kind of shower cream and preparation method |
| CN107432834B (en) * | 2017-07-19 | 2020-10-27 | 广州市皓雨化妆品有限公司 | Antiseptic-free composition with antibacterial effect and preparation method and application thereof |
| CN107432834A (en) * | 2017-07-19 | 2017-12-05 | 广州市皓雨化妆品有限公司 | It is a kind of with fungistatic effect without anti-corrosion composition composition and its preparation method and application |
| CN107582459A (en) * | 2017-10-11 | 2018-01-16 | 广州市禾基生物科技有限公司 | A kind of preservative containing the capsule of weeping forsythia and preparation method thereof |
| CN107669543A (en) * | 2017-10-11 | 2018-02-09 | 广州市禾基生物科技有限公司 | A kind of preservative and preparation method thereof |
| CN107582459B (en) * | 2017-10-11 | 2019-04-02 | 广州市禾基生物科技有限公司 | A kind of preservative and preparation method thereof containing Fructus Forsythiae |
| CN107624758B (en) * | 2017-10-17 | 2020-07-07 | 北京桑普生物化学技术有限公司 | Compound composition containing p-hydroxyacetophenone and preparation method and application thereof |
| CN107624758A (en) * | 2017-10-17 | 2018-01-26 | 北京桑普生物化学技术有限公司 | A kind of complex composition containing parahydroxyacet-ophenone and preparation method and application |
| CN108113908A (en) * | 2018-03-02 | 2018-06-05 | 深圳市澳妆生物科技研究所有限公司 | Lemon grass (Cymbopogon citratus) plants extraction bath elite dew |
| CN111568822A (en) * | 2020-04-14 | 2020-08-25 | 广东润洁日化有限公司 | Compound preservative composition without preservative for cosmetics |
| WO2022093257A1 (en) * | 2020-10-30 | 2022-05-05 | Kimberly-Clark Worldwide, Inc. | Stable antimicrobial formulation concentrate |
| GB2615695A (en) * | 2020-10-30 | 2023-08-16 | Kimberly Clark Co | Stable antimicrobial formulation concentrate |
| EP4085766A1 (en) * | 2021-05-03 | 2022-11-09 | Minagro Srl | Use of 1,2-alkanediols as adjuvant in agriculture |
| BE1029367B1 (en) * | 2021-05-03 | 2022-12-05 | Minagro Srl | USE OF 1,2-ALCANEDIOLS AS AN ADJUVANT IN AGRICULTURE |
| CN115463043A (en) * | 2022-08-25 | 2022-12-13 | 克劳丽化妆品股份有限公司 | Oral care composition and mouthwash |
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Application publication date: 20150429 |