CN105412270A - Chinese herbal medicine compound preparation for treating gout - Google Patents
Chinese herbal medicine compound preparation for treating gout Download PDFInfo
- Publication number
- CN105412270A CN105412270A CN201410486652.0A CN201410486652A CN105412270A CN 105412270 A CN105412270 A CN 105412270A CN 201410486652 A CN201410486652 A CN 201410486652A CN 105412270 A CN105412270 A CN 105412270A
- Authority
- CN
- China
- Prior art keywords
- gout
- benzbromarone
- chinese medicine
- medicine extract
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a Chinese herbal medicine compound preparation for treating gout. The compound preparation is prepared from Chinese herb extract, benzbromarone and medicinal carriers acceptable in pharmacy, wherein the weight part ratio of the Chinese herb extract to the benzbromarone to the acceptable medicinal carriers is 1:(1-4):(2-10). The Chinese herb extract comprises 10-20 parts of stephania terandra, 15-30 parts of hovenia dulcis thunb, 3-8 parts of sargentgloryvine stems, 3-10 parts of emblic leafflower fruits and 3-10 parts of plantain herbs. A pharmacology experiment proves that the compound preparation has the obvious synergistic effect, the concentration of uric acid in serum can be rapidly reduced, and the gout treatment effect is remarkably improved; meanwhile, the medication dosage of each single component is greatly reduced, and the toxic and side effects of the medicinal materials are effectively reduced.
Description
Technical field
The present invention relates to the pharmaceutical composition being used for the treatment of gout, more particularly the present invention relates to a kind of compound Chinese medicinal preparation being used for the treatment of gout.
Background technology
Modern medicine proves, gout is caused by the substance metabolism disorder being called purine a kind of in body.Clinically with the acute arthritis of recurrent exerbation, merge gout calculus, serum Uric Acid Concentration increases, joint deformity and nephropathy etc. are for feature.Gout is not single disease, but a kind of syndrome, be a kind of and the closely-related disease of diet, past attempts is considered to wine disease of muscle, affluenza.
The most important biochemical basis of gout is hyperuricemia.Adult normal about produces uric acid 750mg every day, wherein 80% is endogenous, 20% is exogenous uric acid, these uric acid enter uric acid metabolism pond (being about 1200mg), uric acid about 60% in every day metabolic pool carries out metabolism, and wherein 1/3 about 200mg is through intestinal catabolism, and 2/3 about 400mg is through renal excretion, thus the stable of uric acid level in body can be maintained, wherein any link goes wrong and all can cause hyperuricemia.
Without obvious sign before most of patients outbreak, or only there are tired, general malaise and joint sting etc.Typical onset is often waken up with a start the late into the night because of arthralgia, and pain Progressive symmetric erythrokeratodermia aggravates, and reaches peak at 12 hours, and in tearing sample, lancinate sample or sting and bite sample, is difficult to stand.Affected joints and surrounding tissue is red, swollen, hot, pain and function limitation.More than spontaneous remission in a couple of days or 2 weeks.First-episode many infringements simple joint, part is above occurs in Metatarsophalangeal joint, and in the course of disease afterwards, some patients involves this position.Secondly be the joints such as instep, heel, ankle, knee joint, wrist and elbow, getting involved less in the joints such as shoulder, hip, spinal column and temporo jaw, can involve multiple joint simultaneously, show as polyarthritis.Some patients can have heating, shiver with cold, headache, cardiopalmus and the General Symptoms such as to feel sick, and can accompany that numeration of leukocyte raises, erythrocyte sedimentation rate speeds and increase with c reactive protein.
Modern medicine proves, gout is caused by the substance metabolism disorder being called purine a kind of in body.Clinically with the acute arthritis of recurrent exerbation, merge gout calculus, serum Uric Acid Concentration increases, joint deformity and nephropathy etc. are for feature.Gout is a kind of and the closely-related metabolic disease of life.The pathogenic factor of gout is that the uric acid concentration in blood is too high, forms uric acid crystal deposition in the tissue.Will cause arthritis as being deposited on joint, being deposited on kidney will cause renal calculus.Gout is multiple is born in middle-aged and elderly people, overweight people and brain worker.Gout easily recurs, and after recurrent exerbation, can involve multiple joint, and cause joint deformity, also can cause serious renal function injury.At present for controlling gout outbreak symptom, the medicine eliminating local joint pain mainly contains colchicine, indometacin, phenylbutazone class, ibuprofen class, piroxicam, adrenocortical hormone.Western medicine third Huang relaxes, benzbromarone and sulphinpyrazone to promote the medicine of renal excretion uric acid to mainly contain.The side effect of above medicine long-term taking is comparatively large, mainly to the irreversible infringement of hepatic and renal function.Goat needs uric acid in life-time service medicine control volume to be formed, so the medicine of our employing, mostly be the Chinese medicine of medicine-food two-purpose, life-time service does not produce damage to Liver and kidney.
Summary of the invention
The invention discloses a kind of compound Chinese medicinal preparation being used for the treatment of gout, it is characterized in that, this compound preparation is by Chinese medicine extract, benzbromarone and pharmaceutically acceptable pharmaceutical carrier; Wherein Chinese medicine extract: benzbromarone: the ratio of weight and number of acceptable pharmaceutical carrier is 1:1-4:2 ~ 10; The ratio of weight and number of Chinese medicine extract and benzbromarone is: 1:1 ~ 2.Described Chinese medicine extract is: Radix Stephaniae Tetrandrae 10-20, Semen Hoveniae (Fructus Hoveniae) 15-30, Caulis Sargentodoxae 3-8, Fructus Phyllanthi 3-10, Herba Plantaginis 3-10.
The preparation of Chinese medicine extract refers to: select Radix Stephaniae Tetrandrae, Semen Hoveniae (Fructus Hoveniae), Caulis Sargentodoxae, Fructus Phyllanthi, Herba Plantaginis to be ground into coarse powder respectively, uses 30 ~ 50% (w/w) ethanol of medical material weight 5-10 times amount or water extraction 2-3 time respectively; Each 1-2 hour, filters, merging filtrate, for subsequent use.
Compound Chinese medicinal preparation of the present invention is various tablet, granule, drop pill, pill or Capsule form.
The present invention further discloses the application of compound Chinese medicinal preparation in preparation treatment gout medicine; Comprise constitutional and secondary gout.
Pharmaceutical carrier used by the present invention refers to the compound that pharmaceutically acceptable carrier, excipient and other additive are formed, lactose or starch can be adopted to do carrier, gelatin, sodium carboxymethyl cellulose, methylcellulose, polyvinylpyrrolidone etc. are suitable bonding agent or become granular agent.Can select starch or microcrystalline Cellulose as disintegrating agent, often with Pulvis Talci, santocedl, tristerin, calcium stearate or magnesium etc. are as suitable antiadhesives and lubricant.Such as, tablet is prepared by compacting wet granular.Active component and carrier and optionally with a disintegrate additive composition mixture; the aqueous solution of this mixture and binding agent; alcoholic or moisture alcoholic solution carry out granulating in suitable equipment; dried particles adds other disintegrating agent subsequently, and lubricant and antiplastering aid are by this mixture tabletting.
In prescription of the present invention, all medicine effects are as follows:
The capable water of Radix Stephaniae Tetrandrae, rushes down damp-heat in lower-JIAO.Harness the river swollen tympanites, hygropyretic beriberi, brothers' spasm and pain, tinea scabies swells.For edema beriberi, dysuria, eczema sore, rheumatic arthralgia; Hypertension.
Semen Hoveniae (Fructus Hoveniae): sweet is flat.GUIXIN, spleen channel.Its function: relieving restlessness of quenching the thirst, disappears damp and hot, alcoholic intoxication.Cure mainly: for middle alcoholism, excessive thirst vomiting, difficulty in urination and defecation.It is medicinal sees Tang Materia Medica the earliest.Li Shizhen (1518-1593 A.D.) Compendium of Material Medica says that its ＂ sweet in the mouth, property are flat, nontoxic, has relieving restlessness of quenching the thirst, and goes heat on diaphragm, moistening five ZANG-organs, sharp defecation, merit has significant diuresis with Mel ＂, Semen Hoveniae (Fructus Hoveniae) Saponin has hypotensive effect, and Semen Hoveniae (Fructus Hoveniae) homogenate has lipoid peroxidization resistant and strengthens cold-resistant and heat-resisting function.Containing a large amount of calcium and Semen Hoveniae (Fructus Hoveniae) Saponin in Semen Hoveniae (Fructus Hoveniae), there is central inhibitory action, can convulsion, prevent tetany spasm, can be used to the disease for the treatment of rheumatic arthralgia numbness.
Caulis Sargentodoxae has heat-clearing and toxic substances removing, promoting blood circulation to remove obstruction in the collateral, effect of wind dispelling insecticide; Caulis Sargentodoxae is applicable to stomachache, traumatic injury, dysmenorrhea, the diseases such as Fengshi Guanjie pain; Caulis Sargentodoxae joins Herba Patriniae, heat-clearing and toxic substances removing; Invigorate blood circulation eliminating carbuncle, Caulis Sargentodoxae accessory is stuck up: pathogenic fire purging heat clearing away; Caulis Sargentodoxae joins Radix Sophorae Flavescentis, heat-clearing and toxic substances removing, wind dispelling insecticide.
Fructus Phyllanthi: sweet, sour, puckery, cool.Attach to the lung and stomach meridians.Clearing away heat and cooling blood, promoting digestion and invigorating the stomach, cough-relieving of promoting the production of body fluid.For heat in blood blood stasis, dyspepsia. abdominal distention, cough, laryngalgia, xerostomia.Modern pharmacological research shows have anti-AIDS reverse transcriptase (HIV-1RT) to act on; Protective effect on cancer risk, antimutagenic, teratogenesis effect, antiinflammatory action, blood fat reducing and study of anti-atherogenic effect, antioxidation, anti-aging effects, hepatoprotective effect, to gastrointestinal effect, antiulcer action, anti-CaM antibody, immunoregulation effect, to the regulating action of non-specific immunity, to the potentiation of specific immune function, Detoxication, antibacterial action.
The cardinal principle of Herba Plantaginis treatment gouty arthritis is just that it has diuresis, gouty arthritis caused because uric acid in body is too high, and the excretion of uric acid can be discharged by urine, the diuresis of Herba Plantaginis can make the uric acid in gouty arthritis patient body be discharged by urine, the state of an illness of gout can be alleviated to a certain extent
Research below demonstrates compound Chinese medicinal preparation and have obvious synergism in reduction uric acid in serum concentration.
1 experiment material
1.1 medicines and reagent
Benzbromarone, white powder, buys.The suspendible medicinal liquid of desired concn is configured to for animal gastric infusion before use with 0.5% sodium carboxymethyl cellulose (CMC-Na).
The preparation method of Chinese medicine extract: select Radix Stephaniae Tetrandrae, Semen Hoveniae (Fructus Hoveniae), Caulis Sargentodoxae, Fructus Phyllanthi, Herba Plantaginis to be ground into coarse powder respectively, uses 30 ~ 50% (w/w) ethanol of medical material weight 5-10 times amount or water extraction 2-3 time respectively; Each 1-2 hour, filters, merging filtrate, for subsequent use.
Uric acid detection kit, Bioengineering Research Institute's product is built up in Nanjing.
1.2 animal
Kunming mouse 50, male, body weight (20 ~ 25) g; All purchased from experimental animal feeding center, Tianjin; Feedstuff is the full nutrition block material that Nat'l Pharmaceutical & Biological Products Control Institute produces.
1.3 instrument
PK121R freezing centrifuge, Italian ALC company produces.
722 grating spectrophotometers, Shanghai the 3rd analytical tool factory produces.
2 methods and result
2.1 impacts on gout mice uric acid
After mice overnight fasting, by body weight random packet.Give the Chinese medicine extract of various dose, benzbromarone, Chinese medicine extract and benzbromarone press the compound recipe that different ratio forms, and administration volume is 20ml/kg.3h after administration, gavage gives hypoxanthine 1000mg/kg, and subcutaneous injection Oteracil Potassium 300mg/kg causes Gout Model simultaneously, after 3h, pluck eyeball and get blood 0.5ml, after room temperature leaves standstill 1h, 3000rpm is centrifugal prepares serum, get serum kit measurement uric acid level, whether the compound recipe adopting method of analysis of variance to compare different ratio has synergism.
2.2.1 the synergism of Chinese medicine extract and benzbromarone
Gout mouse stomach gives Chinese medicine extract and benzbromarone compound recipe proportioning produces obvious anti-uric acid rising effect, has certain addition and synergism between two medicines; The compound recipe of proportioning between 1:1 ~ 1:4, proves there is obvious synergism through statistical analysis, improves 41.2% when improve 23.8%, 1:4 when anti-uric acid rising effect improves 23.4%, 1:2 than the sum total that they are used alone with dosage during 1:1.The results are shown in Table 1.
The Chinese medicine extract of table 1 different ratio and benzbromarone share impact on gout mice serum uric acid (
± s)
Note: 1. compare with model control group (variance analysis):
*p<0.05,
*p<0.01,
* *p<0.001;
2.
☆represent that comparing (variance analysis) with folk prescription has synergism.
3. experiment conclusion
Chinese medicine extract and uricosuric agent benzbromarone form compound recipe can reduce normal mouse and gout mice serum uric acid level, and test shows: the compound recipe that Chinese medicine extract and benzbromarone form is have obviously synergism within the scope of 1:1 ~ 1:2 in proportioning.
Model case:
Jiang, man, 47 years old, cadre, extremities joint, systemic sites had tophus, the right hand, ankle arthrosis, Patella arthroncus after the edible wind resistance red week, take medicine about 15 days and recover normal.Check triglyceride reduces to 7.56mmol/l, advises it to adhere to keeping on a diet, strengthening taking exercise.
Week certain, man, 45 years old oneself manage a stationery jobbing house, bear a liking for sea food very much, have the beer, in pact often, three or five clients or friend talk animatedly, period seafood, medicated beer must be indispensable.Cause hyperuricemia, and make Monosodium urate mineralization in articular cavity, cause arthroncus and distortion.About 15 days all diseases of taking medicine fade, and curative effect is obvious.Advise it to adhere to taking, after 1 year, each index is all down to normal value.Advise it to keep on a diet, and effectively control blood glucose.Follow up a case by regular visits to and do not recur for 1 year.
Section certain, man, 48 years old, on April 1st, 2013, occurred right hallux metatarsophalangeal joints pain, redness before two days, very, aching as needle stabbing, oral allopurinol and the indometacin state of an illness are without improvement, and private prosecution has diet risk factor: drank Chinese liquor 200ml before 3 days, eat Eriocheir sinensis for hypnalgia.Examine and see: right hallux metatarsophalangeal joints red and swollen heat pain, joint motion is limited, and local has no tophus, with heating (body temperature 37.5 DEG C) weak asthenia, and thirst with desire to drink, dimly red tongue, thick, yellow and greasy fur, wiry and frequent pulse.Fasting glucose 9.8mmol/L, after the meal 2 hours blood glucose 17.9mmol/L, routine urinalysis: glucose in urine (++) routine urianlysis is normal, blood uric acid 728 μm of ol/L, erythrocyte sedimentation rate: 40mm/ hour.Patient takes the capsule made by the present invention, every day 2 times, each 6g, and after 3 days, conscious arthralgia obviously alleviates, and after 7 days, redness obviously disappears, and after taking medicine 10 days, all diseases disappear.
Compound Chinese medicinal preparation is observed in this research, hepatic and renal function does not occur abnormal when treating metabolic arthritis disease.Prompting said preparation without obvious toxic-side effects, mild in medicine property and, be conducive to long-term taking.The author part follow up a case by regular visits in patient also see the compliance that patient takes medicine and toleration good, year attack times declines to some extent and is combined diabetes, hyperlipidemia, the even positive effect of vascular hypertension, and the acute gouty arthritis patient for recurrent exerbation that can yet be regarded as the control symptom of long-term taking can reduce the Chinese medicine preparation of the safety of outbreak.
Detailed description of the invention
Following embodiment is to further explanation of the present invention instead of limitation of the scope of the invention.Wherein benzbromarone can be buied from market.The Chinese crude drug used in embodiment is all on sale.
Embodiment 1
The preparation of tablet: by Chinese medicine extract 50g, benzbromarone 100g, adds lactose 48g, microcrystalline Cellulose 26g, mix homogeneously, adds appropriate 10%PEG6000 solution and granulates, dry, then adds carboxymethyl starch sodium 10g, magnesium stearate 1.5g, mixing, tabletting, film coating.Described Chinese medicine extract is: Radix Stephaniae Tetrandrae 10, Semen Hoveniae (Fructus Hoveniae) 15, Caulis Sargentodoxae 3, Fructus Phyllanthi 10, Herba Plantaginis 3, be ground into coarse powder respectively, uses 30% (w/w) ethanol of medical material weight 5 times amount or water extraction 2 times respectively; Each 1 hour, filter, merging filtrate, for subsequent use.
Embodiment 2
Chinese medicine extract 40g, benzbromarone 60g, add dextrin 100g, lactose 270g, granulates with pure water, dry, encapsulated, obtained 1000 seed lac wafers.Described Chinese medicine extract is: Radix Stephaniae Tetrandrae 12, Semen Hoveniae (Fructus Hoveniae) 13, Caulis Sargentodoxae 10, Fructus Phyllanthi 8, Herba Plantaginis 10, be ground into coarse powder respectively, uses 35% (w/w) ethanol of medical material weight 5 times amount or water extraction 2 times respectively; Each 1 hour, filter, merging filtrate, for subsequent use.
Embodiment 3
Chinese medicine extract 60g, benzbromarone 120g, Radix Stephaniae Tetrandrae 15, Semen Hoveniae (Fructus Hoveniae) 15, Caulis Sargentodoxae 3, Fructus Phyllanthi 6, Caulis Sargentodoxae 3, Herba Plantaginis 10.
Be ground into coarse powder respectively, use 30% (w/w) ethanol of medical material weight 5 times amount or water extraction 2 times respectively; Each 1 hour, filter, merging filtrate, for subsequent use.Mixing, sieves, then mixs homogeneously with starch 300g, with starch slurry (get starch 220g water and make starch slurry) granule processed, sieve, dry, encapsulated.
Claims (5)
1. be used for the treatment of a compound Chinese medicinal preparation for gout, it is characterized in that, this compound preparation is by Chinese medicine extract, benzbromarone and pharmaceutically acceptable pharmaceutical carrier; Wherein Chinese medicine extract: benzbromarone: the ratio of weight and number of acceptable pharmaceutical carrier is 1:1-4:2 ~ 10; Described Chinese medicine extract is: Radix Stephaniae Tetrandrae 10-20, Semen Hoveniae (Fructus Hoveniae) 15-30, Caulis Sargentodoxae 3-8, Fructus Phyllanthi 3-10, Herba Plantaginis 3-10.
2. the compound Chinese medicinal preparation of claim 1, wherein Chinese medicine extract refers to: select Radix Stephaniae Tetrandrae, Semen Hoveniae (Fructus Hoveniae), Caulis Sargentodoxae, Fructus Phyllanthi, Herba Plantaginis to be ground into coarse powder respectively, uses 30 ~ 50% (w/w) ethanol of medical material weight 5-10 times amount or water extraction 2-3 time respectively; Each 1-2 hour, filters, merging filtrate, for subsequent use.
3. claim 1 compound Chinese medicinal preparation, wherein the ratio of weight and number of Chinese medicine extract and benzbromarone is: 1:1 ~ 2.
4. the compound Chinese medicinal preparation of claim 5, wherein said compound Chinese medicinal preparation is various tablet, granule, drop pill, pill or Capsule form.
5. the application of compound Chinese medicinal preparation in preparation treatment gout medicine of any one of claim 1-4; Comprise constitutional and secondary gout.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410486652.0A CN105412270A (en) | 2014-09-22 | 2014-09-22 | Chinese herbal medicine compound preparation for treating gout |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410486652.0A CN105412270A (en) | 2014-09-22 | 2014-09-22 | Chinese herbal medicine compound preparation for treating gout |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105412270A true CN105412270A (en) | 2016-03-23 |
Family
ID=55491119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410486652.0A Pending CN105412270A (en) | 2014-09-22 | 2014-09-22 | Chinese herbal medicine compound preparation for treating gout |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105412270A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078543A (en) * | 2011-01-12 | 2011-06-01 | 湖南省药物安全评价研究中心 | Traditional Chinese medicine preparation for treating gout and preparation method thereof |
| CN102813870A (en) * | 2012-09-21 | 2012-12-12 | 天津九翁宝生物科技研究中心 | Chinese herbal compound preparation used for treating alcoholism and gout and preparation method and application thereof |
| CN103386043A (en) * | 2013-07-16 | 2013-11-13 | 郭强 | Chinese medicine preparation for treating hyperuricemia |
| CN104161912A (en) * | 2013-05-16 | 2014-11-26 | 康普药业股份有限公司 | Tongfengshu capsule and preparation method thereof |
-
2014
- 2014-09-22 CN CN201410486652.0A patent/CN105412270A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078543A (en) * | 2011-01-12 | 2011-06-01 | 湖南省药物安全评价研究中心 | Traditional Chinese medicine preparation for treating gout and preparation method thereof |
| CN102813870A (en) * | 2012-09-21 | 2012-12-12 | 天津九翁宝生物科技研究中心 | Chinese herbal compound preparation used for treating alcoholism and gout and preparation method and application thereof |
| CN104161912A (en) * | 2013-05-16 | 2014-11-26 | 康普药业股份有限公司 | Tongfengshu capsule and preparation method thereof |
| CN103386043A (en) * | 2013-07-16 | 2013-11-13 | 郭强 | Chinese medicine preparation for treating hyperuricemia |
Non-Patent Citations (1)
| Title |
|---|
| 邓长财: ""苯溴马隆与中药联用治疗高尿酸血症/痛风32例"", 《山西中医学院学报》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100531769C (en) | Chinese medicine composition for treating gout and preparing method thereof | |
| CN101632827B (en) | Traditional Chinese medicine composition for treating psoriasis and preparation method thereof | |
| CN102240372B (en) | Medicine for treating gouty arthritis and hyperuricemia and preparation method thereof | |
| CN113288925A (en) | Traditional Chinese medicine composition for preventing and treating gout | |
| CN102813870B (en) | Chinese herbal compound preparation used for treating alcoholism and gout and preparation method and application thereof | |
| CN104173458B (en) | A kind of have Chinese medicine composition preventing and treating hyperuricemia effect and preparation method thereof | |
| CN103028002A (en) | Pharmaceutical preparation for treating gout and preparation method thereof | |
| CN109820943B (en) | Zhuang medicine preparation for treating gout and preparation method thereof | |
| CN104815318A (en) | Traditional Chinese medicine preparation for treating gout | |
| CN109820971A (en) | A kind of drug with antigout effect | |
| CN105287748A (en) | Traditional Chinese medicine preparation for treating hyperuricemia and preparation method thereof | |
| CN104337989A (en) | Traditional Chinese medicine composition containing centipeda minima and frankincense for treating gout | |
| CN112022966B (en) | Traditional Chinese medicine composition for preventing, relieving and/or treating hyperuricemia | |
| CN105412270A (en) | Chinese herbal medicine compound preparation for treating gout | |
| WO2016127771A1 (en) | Application of 20(r)-ginsenoside rg3 in preparing drug or healthcare product for alleviating or/and treating rheumatoid disease and drug containing 20(r)-ginsenoside rg3 | |
| CN109481469A (en) | Application of the drug and colla carapacis et plastri testudinis of a kind of colla carapacis et plastri testudinis treatment gout in preparation treatment gout drug | |
| CN104337909A (en) | Traditional Chinese medicine composition containing aspongopus for treating gout | |
| CN104491418A (en) | Traditional Chinese medicinal preparation for treating ulcerative colitis | |
| CN103933154A (en) | Traditional Chinese medicine composition for treating gout disease and preparation method thereof | |
| CN103127358B (en) | Traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method | |
| CN112826888B (en) | Traditional Chinese medicine composition for gout and preparation method and application thereof | |
| CN114392331A (en) | Preparation containing Agkistrodon for treating gouty arthritis | |
| CN104435149A (en) | Traditional Chinese medicine composition containing kadsura pepper stem for treating gout | |
| CN104337889B (en) | A kind of Chinese medicine composition of the treatment gout containing Lumbricus | |
| CN105796666A (en) | Diarrhoea-resistant traditional Chinese medicine composition and preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160323 |