CN105362562A - Pharmaceutical composition for treating herpes zoster - Google Patents

Pharmaceutical composition for treating herpes zoster Download PDF

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Publication number
CN105362562A
CN105362562A CN201510948828.4A CN201510948828A CN105362562A CN 105362562 A CN105362562 A CN 105362562A CN 201510948828 A CN201510948828 A CN 201510948828A CN 105362562 A CN105362562 A CN 105362562A
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parts
radix
herba
pharmaceutical composition
herpes zoster
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孙霞
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Jinan Xinshidai Medicine Science and Technology Co Ltd
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Jinan Xinshidai Medicine Science and Technology Co Ltd
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/88—Liliopsida (monocotyledons)
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/88—Liliopsida (monocotyledons)
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Abstract

The invention belongs to the technical field of medicine, and particularly relates to a pharmaceutical composition for treating herpes zoster. The pharmaceutical composition for treating the herpes zoster is prepared from, by weight, 4-6 parts of Chinese fanpalm seeds, 4-6 parts of fewflower lysionotus herb, 4-6 parts of herba pimpinellae, 4-6 parts of roots of champion pentasacme, 4-6 parts of tubers of serrate sikoku jackinthepulpit, 4-6 parts of nude pronephrium rhizomes, 4-6 parts of all-grass of winkled marshweed, 4-6 parts of perny germander roots, 4-6 parts of pilose bushclover herb and 4-6 parts of leaves of lance coreopsis. All the medicines are combined for use, the effects of clearing heat, removing toxicity, activating the blood, removing swelling, regulating Qi, removing stasis, dispersing blood stasis and stopping pain are achieved, and the pharmaceutical composition has the advantages of being high in cure rate and short in recovery time when the pharmaceutical composition is used for treating the herpes zoster.

Description

A kind of pharmaceutical composition for the treatment of herpes zoster
Technical field
The invention belongs to medical art, be specifically related to a kind of pharmaceutical composition for the treatment of herpes zoster.
Background technology
Herpes zoster is the acute inflammation dermatoses caused by varicella zoster virus, and the traditional Chinese medical science is called " skirt-roof HUOLONG ", " herpes zoster ".Among the peoplely be commonly called as " herpes zoster ", " herpes zoster ".Its main feature, for bunch catchmenting bubble, to be trooped zonal distribution along side peripheral nerve, often with obvious neuralgia.People is unique host of varicella zoster virus, and virus enters blood through respiratory mucosa and forms viremia, chickenpox occurs or in inapparent infection, later virus can be hidden for a long time in spinal cord posterior root ganglion or ganglia sensorialia nervi encephalici.When stimulating (as wound, fatigue, malignant tumor or weak etc. after being ill) to cause Abwehrkraft des Koepers to decline when body is subject to certain, latent virus is activated, along this nerve of the descending arrival of sensory nerve axon arrange region skin in copy generation vesicle, nerve of simultaneously getting involved is inflamed, necrosis, produces neuralgia.
The Therapeutic Principle of western medicine to herpes zoster is antiviral, anti-inflammatory analgetic and prevents secondary infection.Antiviral agents has vidarabine, acycloguanosine and interferon etc.Anti-inflammation analgesic is as aspirin, vitamin B1, vitamin B12 etc.Affected part, local can (Borneolum Syntheticum 2g, zinc oxid oil be added to l00 and be coated with outward for Radix Sangusorbae l0g, Radix Arnebiae (Radix Lithospermi) 5g with 2% aldrich mixture or compound recipe Radix Sanguisorbae zinc oxid oil.If there is secondary infection, put on the skin outside available neomycin ointment.Said medicine curative effect is all not ideal.
Therefore, need to find the medicine being used for the treatment of herpes zoster.
Summary of the invention
Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, provides a kind of pharmaceutical composition for the treatment of herpes zoster.
The present invention is achieved through the following technical solutions:
Treat a pharmaceutical composition for herpes zoster, be made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 4-6 part, Herba Lysionoti Pauciflori 4-6 part, Radix Pimpinellae Candolleanae 4-6 part, Radix Pentasacmi championii 4-6 part, Rhizoma Arisaemati 4-6 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 4-6 part, Herba Limnophilae rugosae 4-6 part, Radix Teucrii Pernyi 4-6 part, Herba lespedezae pilosae 4-6 part, Folium Coreopsis lanceolatae 4-6 part.
Preferably, the pharmaceutical composition of above-mentioned treatment herpes zoster, is made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 5-7 part, Herba Lysionoti Pauciflori 5-7 part, Radix Pimpinellae Candolleanae 5-7 part, Radix Pentasacmi championii 5-7 part, Rhizoma Arisaemati 5-7 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 5-7 part, Herba Limnophilae rugosae 5-7 part, Radix Teucrii Pernyi 5-7 part, Herba lespedezae pilosae 5-7 part, Folium Coreopsis lanceolatae 5-7 part.
Preferred, the pharmaceutical composition of above-mentioned treatment herpes zoster, is made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 6 parts, Herba Lysionoti Pauciflori 6 parts, Radix Pimpinellae Candolleanae 6 parts, Radix Pentasacmi championii 6 parts, Rhizoma Arisaemati 6 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 6 parts, Herba Limnophilae rugosae 6 parts, Radix Teucrii Pernyi 6 parts, Herba lespedezae pilosae 6 parts, Folium Coreopsis lanceolatae 6 parts.
The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.
The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.
The indication of medicine of the present invention: be used for the treatment of herpes zoster.
The method of preparation and use of medicine of the present invention: be ground into fine powder by after each composition Chinese medicine mixing of medicine of the present invention, for subsequent use.Get fine powder when using appropriate, mix well deposited affected part with water, tea, vinegar, Ovum Gallus domesticus album or glycerol etc.
The standard of fine powder is on the books in Chinese Pharmacopoeia 2010 editions 1 annex.
The taboo item of medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.
In medicine of the present invention,
Chinese fanpalm seed another name seed of Livistona chinensis R.Br. is babassu Semen livistonae chinensis Livistonachinensis(Jacq.) seed of R.Br..Sweet in the mouth; Bitter; Property is put down.Function blood circulation promoting and blood stasis dispelling; Hard masses softening and resolving.Main chronic hepatitis; Lump in the abdomen.
The black black bone of Herba Lysionoti Pauciflori another name, Radix Loxostigmatis griffithii, Lysionotus pauciflorus Maxim., little Herba Lycopi, Herba Lysionoti carnosae, rock tea, Herba Ophiorrhizae japonicae, rock orchid, Ba Yancao, the red grass of lung, Semen Benincasae grass, Parmelia saxatilis Ach., puerperal tea, Eupatorium formosanum Hayata., stone Radix Notoginseng, Shi Hu, Cicerbita azurea (Ledeb.) Beavuerd, Radix Loxostigmatis griffithii, stone Fructus Myricae rubrae, rock head Radix Notoginseng, rock strip, bamboo do not sting, member orchid, pattern rake.For the herb of Gesneriaceae Herba Lysionoti Pauciflori LysionotuspauciflorusMaxim..Bitter in the mouth; Pungent; Property is put down.Function wind dehumidifies; Preventing phlegm from forming and stopping coughing; Blood stasis dispelling stimulates the menstrual flow.Main air pain of dampness syndrome; Cough with asthma abundant expectoration; Menoxenia; Dysmenorrhea; Traumatic injury.
That Radix Pimpinellae Candolleanae another name Rhizoma valerianae latifoliae, mountain Radix Angelicae Sinensis, Horse hoof Radix Saposhnikoviae, JIUYUE Pemisetum flaccidum Griseb, all over the body string, tripodia Cicadae, Pemisetum flaccidum Griseb, Yangshan are smelly, Rhizoma typhonii divaricati, clearly Radix Angelicae Sinensis, sheep are had a strong smell is smelly, Herba Calthae, Fructus Piperis, lamb have a strong smell, Radix Pimpinellae Candolleanae, nine Ns dry, sheep mountain is smelly, Great Cold medicine, grass of cooling down, rabbit ear Radix Saposhnikoviae, little hero, little Flos Chrysanthemi, be root or the herb of samphire Folium Pruni Pimpinella anisum Linn. PimpinellacandolleanaWighy day Arn.Acrid in the mouth; Micro-hardship; Warm in nature.Return lung; Spleen; Stomach; Liver Channel.Function warming spleen and stomach for dispelling cold; Promoting the circulation of QI to relieve pain; Expelling wind and activating blood circulation; Removing toxic substances and promoting subsidence of swelling.The cold pain of main gastral cavity abdomen; Dyspepsia; Dysentery; Flu; Cough; Infantile convulsion; Leucorrhea; Hernia; The testis swelling and hanging down of either of the testes; Scrofula; Treating swelling and pain by traumatic injury; Carbuncle sore tumefacting virus; Venom.
Radix Pentasacmi championii another name five, southern stone Herba seu Radix Metaplexis hemsleyanae, false fourth Diao Zhu, Herba Pteridis Multifidae, full grass, Radix Homonoiae Ripariae, be the herb of dicotyledon medicine asclepiadaceae stone Herba seu Radix Metaplexis hemsleyanae PendasacmechampioniiBenth..Bitter in the mouth; Micro-pungent; Cool in nature.Return liver; Gallbladder meridian.Function is fallen apart wind heat clearing away; Removing toxic substances and promoting subsidence of swelling.Main anemopyretic cold; Cough; Pharyngalgia; Conjunctival congestion; Hepatitis; Venom.
Rhizoma Arisaemati another name LUBIANHUANG, Serpentis Semen Maydis, old Serpentis Semen Maydis are the tuber of aroid Rhizoma Arisaemati ArisaemasikokianumFuanch. day or full edge Rhizoma Arisaemati Sav.var.s day tatum (Makino) Hand.-Mazz [A.sazensoovar.serratumMakino] 2.ArisaemasikokianumFranch. day Sav..Bitter in the mouth, pungent; Warm in nature.Return lung; Liver Channel.Function drying dampness to eliminate phlegm; Relieving spasm by subduing liver-wind; Reducing swelling and alleviating pain.Main productive cough due to phlegm-damp; Dizziness due to wind-phlegm; Epilepsy; Apoplexy; Facial hemiparalysis; Tetanus; Carbuncle; Venom.
Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching calls large plumage crescent Herba pteridii latiusculi, Coniogramme japonica (Thunb.) Diels, derives from fern Athyriaceae Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching Abacopterismultilineata(Wall.) Ching, is used as medicine with root stock.Bitter in the mouth, cold in nature.Function dredge the meridian passage, dampness removing of regulating the flow of vital energy.Cure mainly impairment caused by overstrain, peratodynia, dysentery, menoxenia.
Herba Limnophilae rugosae another name Tian Gencao, water mint, Rhizoma begoniae pedatifidae, water Herba Schizonepetae, ripples perfume, wrinkle leaf Herba Limnophilae sessiliflorae are the herb of goatweed Limnophila rugosa NitellaexpansaAllen, Limnophilarugosa (Roth) Merr..Acrid in the mouth; Sweet; Warm in nature.Return lung; Spleen; Stomach warp.Function invigorating spleen to remove dampness; Activating QI to eliminate phlegm.Main edema; Stomachache; Distension and fullness of the chest and abdomen; Cough; Children's's infantile dyspepsia; Furuncle.
Radix Teucrii Pernyi another name Mount Lushan spice, derives from Labiatae and spends Phryganeajaponica Ml. TeucriumpernyiFranch. in vain, be used as medicine with root.Taste is micro-sweet, warm in nature.Function invigorating spleen to remove dampness, removing toxic substances.Cure mainly dysentery.
Herba lespedezae pilosae another name Herba cassiae torae, derives from pulse family Lespedeza plant Herba lespedezae pilosae Lespedezapilosa(Thunb.) Sieb. day Zucc., is used as medicine with root and Herb.Bitter in the mouth, pungent, property is put down.Function heat clearing away eliminating stagnation, promoting blood circulation and stopping pain, line water detumescence.For lymphoid tuberculosis, cold abscess, deficiency-heat is not moved back, edema, waist hamstring osteodynia; Mastitis are controlled in external.
Folium Coreopsis lanceolatae another name Coreopsis lanceolata, sword-like leave coreopsis, derive from Compositae Folium Coreopsis lanceolatae CoreopsislanceolataL., with all herbal medicine.Acrid in the mouth, property is put down.Function blood stasis dispersing and deswelling, heat-clearing and toxic substances removing.Cure mainly knife injury, innominate toxic swelling.
In medicine of the present invention, Chinese fanpalm seed blood circulation promoting and blood stasis dispelling, hard masses softening and resolving; Herba Lysionoti Pauciflori heat clearing and damp drying, reducing swelling and alleviating pain; Radix Pimpinellae Candolleanae promoting the circulation of QI to relieve pain, dissipating blood stasis for subsidence of swelling; Radix Pentasacmi championii falls apart wind heat clearing away, removing toxic substances and promoting subsidence of swelling; Rhizoma Arisaemati drying dampness to eliminate phlegm, reducing swelling and alleviating pain; Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching dredge the meridian passage, regulating QI to expel dampness; Herba Limnophilae rugosae, Radix Teucrii Pernyi invigorating spleen to remove dampness, activating QI to eliminate phlegm; Herba lespedezae pilosae heat clearing away eliminating stagnation, promoting blood circulation and stopping pain; Folium Coreopsis lanceolatae blood stasis dispersing and deswelling, heat-clearing and toxic substances removing.All medicines share, and play heat-clearing and toxic substances removing altogether, promoting blood circulation and detumescence, eliminating stagnation of regulating the flow of vital energy, the effect of blood-activating analgetic.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1
Treat a pharmaceutical composition for herpes zoster, each crude drug weight proportion is as follows:
Chinese fanpalm seed 6g, Herba Lysionoti Pauciflori 6g, Radix Pimpinellae Candolleanae 6g, Radix Pentasacmi championii 6g, Rhizoma Arisaemati 6g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 6g, Herba Limnophilae rugosae 6g, Radix Teucrii Pernyi 6g, Herba lespedezae pilosae 6g, Folium Coreopsis lanceolatae 6g.
Method of preparation and use: be ground into fine powder by after each composition Chinese medicine mixing of medicine of the present invention, for subsequent use.Get fine powder when using appropriate, mix well deposited affected part with water, tea, vinegar, Ovum Gallus domesticus album or glycerol etc.
Embodiment 2
Treat a pharmaceutical composition for herpes zoster, each crude drug weight proportion is as follows:
Chinese fanpalm seed 5g, Herba Lysionoti Pauciflori 7g, Radix Pimpinellae Candolleanae 5g, Radix Pentasacmi championii 7g, Rhizoma Arisaemati 5g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 7g, Herba Limnophilae rugosae 5g, Radix Teucrii Pernyi 7g, Herba lespedezae pilosae 5g, Folium Coreopsis lanceolatae 7g.
Method of preparation and use is with embodiment 1.
Embodiment 3
Treat a pharmaceutical composition for herpes zoster, each crude drug weight proportion is as follows:
Chinese fanpalm seed 7g, Herba Lysionoti Pauciflori 5g, Radix Pimpinellae Candolleanae 7g, Radix Pentasacmi championii 5g, Rhizoma Arisaemati 7g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 5g, Herba Limnophilae rugosae 7g, Radix Teucrii Pernyi 5g, Herba lespedezae pilosae 7g, Folium Coreopsis lanceolatae 5g.
Method of preparation and use is with embodiment 1.
Embodiment 4
Treat a pharmaceutical composition for herpes zoster, each crude drug weight proportion is as follows:
Chinese fanpalm seed 4g, Herba Lysionoti Pauciflori 6g, Radix Pimpinellae Candolleanae 4g, Radix Pentasacmi championii 6g, Rhizoma Arisaemati 4g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 6g, Herba Limnophilae rugosae 4g, Radix Teucrii Pernyi 6g, Herba lespedezae pilosae 4g, Folium Coreopsis lanceolatae 6g.
Method of preparation and use is with embodiment 1.
Embodiment 5
Treat a pharmaceutical composition for herpes zoster, each crude drug weight proportion is as follows:
Chinese fanpalm seed 6g, Herba Lysionoti Pauciflori 4g, Radix Pimpinellae Candolleanae 6g, Radix Pentasacmi championii 4g, Rhizoma Arisaemati 6g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 4g, Herba Limnophilae rugosae 6g, Radix Teucrii Pernyi 4g, Herba lespedezae pilosae 6g, Folium Coreopsis lanceolatae 4g.
Method of preparation and use is with embodiment 1.
Carried out clinical pharrnacokinetics test to medicine of the present invention, Details as Follows:
1 clinical data
The routine herpes zoster of 1.1 physical data 40 is divided into two groups at random.Observation group 20 example, male l2 example, female 8 example; Age l5-72 year; Course of disease 2-7d; Wherein 3 examples take antiviral agents and quiet antibiotic therapy history, but symptom is all not improved.Matched group 20 example, man 10 example, female 10 example; 9 ~ 76 years old age; Course of disease 1-7d.All cases have bunch collection shape herpes and neuralgia along the one-sided distribution of peripheral nerve, two groups of ages, sex and course of disease there was no significant differences.
1.2 therapeutic scheme observation groups: the 1 affected part pharmaceutical composition powder of the treatment herpes zoster of the rear herbal tea mediation embodiment of the present invention 1, spreads on affected part.Matched group: injection of interferon, virazole, VB, person as obvious in neuralgia, can suitably add with dexamethasone sodium phosphate injection; Acyclovir slice, VB sheet for oral administration; External Ah former times Wei ointment.Treatment group and matched group medication 6d were 1 course for the treatment of, and 3 courses for the treatment of evaluate curative effect.
1.3 criterion of therapeutical effect recoveries from illness: skin bleb drying incrustation, occur without new herpes, pain disappears substantially.Effective: skin bleb drying incrustation, but leave over post herpetic neuralgia.Invalid: disease feelings have no and are clearly better.
2 results
Observation group 20,11 examples of fully recovering 1 course for the treatment of, 3 examples of fully recovering 2 courses for the treatment of, 3 courses for the treatment of effective 5 are routine, cure rate 95%.Matched group: in 20 examples, 8 examples of fully recovering 1 course for the treatment of, 4 examples of fully recovering 2 courses for the treatment of, 2 sides of fully recovering 3 courses for the treatment of, cure rate 70%.Two groups through statistical procedures: cure rate, fully recover the time used, and observation group is obviously better than matched group.

Claims (3)

1. treat a pharmaceutical composition for herpes zoster, be made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 4-6 part, Herba Lysionoti Pauciflori 4-6 part, Radix Pimpinellae Candolleanae 4-6 part, Radix Pentasacmi championii 4-6 part, Rhizoma Arisaemati 4-6 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 4-6 part, Herba Limnophilae rugosae 4-6 part, Radix Teucrii Pernyi 4-6 part, Herba lespedezae pilosae 4-6 part, Folium Coreopsis lanceolatae 4-6 part.
2. the pharmaceutical composition for the treatment of herpes zoster according to claim 2, is characterized in that, is made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 5-7 part, Herba Lysionoti Pauciflori 5-7 part, Radix Pimpinellae Candolleanae 5-7 part, Radix Pentasacmi championii 5-7 part, Rhizoma Arisaemati 5-7 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 5-7 part, Herba Limnophilae rugosae 5-7 part, Radix Teucrii Pernyi 5-7 part, Herba lespedezae pilosae 5-7 part, Folium Coreopsis lanceolatae 5-7 part.
3. the pharmaceutical composition for the treatment of herpes zoster according to claim 2, is characterized in that, is made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 6 parts, Herba Lysionoti Pauciflori 6 parts, Radix Pimpinellae Candolleanae 6 parts, Radix Pentasacmi championii 6 parts, Rhizoma Arisaemati 6 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 6 parts, Herba Limnophilae rugosae 6 parts, Radix Teucrii Pernyi 6 parts, Herba lespedezae pilosae 6 parts, Folium Coreopsis lanceolatae 6 parts.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116808084A (en) * 2023-03-27 2023-09-29 黄标 Application of dicranopteris pedata in preparing medicament for treating herpes zoster

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CN103463495A (en) * 2013-09-23 2013-12-25 陈军 Drug for treating senile postoperative acute mental disorders
CN103463496A (en) * 2013-09-23 2013-12-25 祝爱莲 Drug for treating ankylosing spondylitis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103463495A (en) * 2013-09-23 2013-12-25 陈军 Drug for treating senile postoperative acute mental disorders
CN103463496A (en) * 2013-09-23 2013-12-25 祝爱莲 Drug for treating ankylosing spondylitis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116808084A (en) * 2023-03-27 2023-09-29 黄标 Application of dicranopteris pedata in preparing medicament for treating herpes zoster

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