CN105362565A - Medicine composition for treating erysipelas on lower limbs - Google Patents

Abstract

The invention belongs to the technical field of medicines and particularly relates to a medicine composition for treating erysipelas on lower limbs. The medicine composition is prepared from, by weight, 4-6 parts of Chinese fanpalm seeds, 4-6 parts of a fewflower lysionotus herb, 4-6 parts of roots of candolle pimpinella, 4-6 parts of roots of champion pentasacme, 4-6 parts of tubers of serrate sikoku jackinthepulpit, 4-6 parts of nude pronephrium rhizomes, 4-6 parts of all-grass of winkled marshweed, 4-6 parts of perny germander roots, 4-6 parts of a pilose bushclover herb and 4-6 parts of lance coreopsis leaves. The medicinal materials are used in a combined mode and jointly have the effects of clearing away heat and toxic materials, promoting blood circulation to remove meridian obstruction, dispersing blood stasis, removing stasis and relieving swelling and pain, and the medicine composition is used for treating the erysipelas on lower limbs and has the advantages of being high in cure rate and total effective rate.

Description

A kind of pharmaceutical composition for the treatment of lower limb injury

Technical field

The invention belongs to medical art, be specifically related to a kind of pharmaceutical composition for the treatment of lower limb injury.

Background technology

Western medicine thinks that erysipelas is that one involves the vasculolymphatic infection of high dermis, and Main Pathogenic Bacteria is A group B Hemolytic streptococcus, and motherland's medical science thinks that erysipelas is that a kind of skin is rubescent suddenly, and color is as being coated with red acute infectious diseases.Send out in shank foot person, " surgery great achievement " name lower limb urticaria, " surgeon is complete works of " claims erysipelas.Patient's topical manifestations is lamellar erythema, and color is scarlet, and centre is lighter, clear-cut margin, and slightly swells.Doctor trained in Western medicine confirms that erysipelas is the acute inflammation of the skin shallow-layer lymphatic meshwork that causes of Hemolytic streptococcus and surrounding soft tissue, red, swollen, hot with skin of lower extremity, be principal character bitterly, and with heating in various degree.Current common antibiotics treatment, but curative effect is good not.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, provides a kind of pharmaceutical composition for the treatment of lower limb injury.

The present invention is achieved through the following technical solutions:

Treat a pharmaceutical composition for lower limb injury, be made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 4-6 part, Herba Lysionoti Pauciflori 4-6 part, Radix Pimpinellae Candolleanae 4-6 part, Radix Pentasacmi championii 4-6 part, Rhizoma Arisaemati 4-6 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 4-6 part, Herba Limnophilae rugosae 4-6 part, Radix Teucrii Pernyi 4-6 part, Herba lespedezae pilosae 4-6 part, Folium Coreopsis lanceolatae 4-6 part.

Preferably, the pharmaceutical composition of above-mentioned treatment lower limb injury, is made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 5-7 part, Herba Lysionoti Pauciflori 5-7 part, Radix Pimpinellae Candolleanae 5-7 part, Radix Pentasacmi championii 5-7 part, Rhizoma Arisaemati 5-7 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 5-7 part, Herba Limnophilae rugosae 5-7 part, Radix Teucrii Pernyi 5-7 part, Herba lespedezae pilosae 5-7 part, Folium Coreopsis lanceolatae 5-7 part.

Preferred, the pharmaceutical composition of above-mentioned treatment lower limb injury, is made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 6 parts, Herba Lysionoti Pauciflori 6 parts, Radix Pimpinellae Candolleanae 6 parts, Radix Pentasacmi championii 6 parts, Rhizoma Arisaemati 6 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 6 parts, Herba Limnophilae rugosae 6 parts, Radix Teucrii Pernyi 6 parts, Herba lespedezae pilosae 6 parts, Folium Coreopsis lanceolatae 6 parts.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

The indication of medicine of the present invention: be used for the treatment of lower limb injury.

The method of preparation and use of medicine of the present invention: be ground into fine powder by after each composition Chinese medicine mixing of medicine of the present invention, for subsequent use.Get fine powder when using appropriate, mix well deposited affected part with water, tea, vinegar, Ovum Gallus domesticus album, vaseline or glycerol etc.

The standard of fine powder is on the books in Chinese Pharmacopoeia 2010 editions 1 annex.

The taboo item of medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

In medicine of the present invention,

Chinese fanpalm seed another name seed of Livistona chinensis R.Br. is babassu Semen livistonae chinensis Livistonachinensis(Jacq.) seed of R.Br..Sweet in the mouth; Bitter; Property is put down.Function blood circulation promoting and blood stasis dispelling; Hard masses softening and resolving.Main chronic hepatitis; Lump in the abdomen.

The black black bone of Herba Lysionoti Pauciflori another name, Radix Loxostigmatis griffithii, Lysionotus pauciflorus Maxim., little Herba Lycopi, Herba Lysionoti carnosae, rock tea, Herba Ophiorrhizae japonicae, rock orchid, Ba Yancao, the red grass of lung, Semen Benincasae grass, Parmelia saxatilis Ach., puerperal tea, Eupatorium formosanum Hayata., stone Radix Notoginseng, Shi Hu, Cicerbita azurea (Ledeb.) Beavuerd, Radix Loxostigmatis griffithii, stone Fructus Myricae rubrae, rock head Radix Notoginseng, rock strip, bamboo do not sting, member orchid, pattern rake.For the herb of Gesneriaceae Herba Lysionoti Pauciflori LysionotuspauciflorusMaxim..Bitter in the mouth; Pungent; Property is put down.Function wind dehumidifies; Preventing phlegm from forming and stopping coughing; Blood stasis dispelling stimulates the menstrual flow.Main air pain of dampness syndrome; Cough with asthma abundant expectoration; Menoxenia; Dysmenorrhea; Traumatic injury.

That Radix Pimpinellae Candolleanae another name Rhizoma valerianae latifoliae, mountain Radix Angelicae Sinensis, Horse hoof Radix Saposhnikoviae, JIUYUE Pemisetum flaccidum Griseb, all over the body string, tripodia Cicadae, Pemisetum flaccidum Griseb, Yangshan are smelly, Rhizoma typhonii divaricati, clearly Radix Angelicae Sinensis, sheep are had a strong smell is smelly, Herba Calthae, Fructus Piperis, lamb have a strong smell, Radix Pimpinellae Candolleanae, nine Ns dry, sheep mountain is smelly, Great Cold medicine, grass of cooling down, rabbit ear Radix Saposhnikoviae, little hero, little Flos Chrysanthemi, be root or the herb of samphire Folium Pruni Pimpinella anisum Linn. PimpinellacandolleanaWighy day Arn.Acrid in the mouth; Micro-hardship; Warm in nature.Return lung; Spleen; Stomach; Liver Channel.Function warming spleen and stomach for dispelling cold; Promoting the circulation of QI to relieve pain; Expelling wind and activating blood circulation; Removing toxic substances and promoting subsidence of swelling.The cold pain of main gastral cavity abdomen; Dyspepsia; Dysentery; Flu; Cough; Infantile convulsion; Leucorrhea; Hernia; The testis swelling and hanging down of either of the testes; Scrofula; Treating swelling and pain by traumatic injury; Carbuncle sore tumefacting virus; Venom.

Radix Pentasacmi championii another name five, southern stone Herba seu Radix Metaplexis hemsleyanae, false fourth Diao Zhu, Herba Pteridis Multifidae, full grass, Radix Homonoiae Ripariae, be the herb of dicotyledon medicine asclepiadaceae stone Herba seu Radix Metaplexis hemsleyanae PendasacmechampioniiBenth..Bitter in the mouth; Micro-pungent; Cool in nature.Return liver; Gallbladder meridian.Function is fallen apart wind heat clearing away; Removing toxic substances and promoting subsidence of swelling.Main anemopyretic cold; Cough; Pharyngalgia; Conjunctival congestion; Hepatitis; Venom.

Rhizoma Arisaemati another name LUBIANHUANG, Serpentis Semen Maydis, old Serpentis Semen Maydis are the tuber of aroid Rhizoma Arisaemati ArisaemasikokianumFuanch. day or full edge Rhizoma Arisaemati Sav.var.s day tatum (Makino) Hand.-Mazz [A.sazensoovar.serratumMakino] 2.ArisaemasikokianumFranch. day Sav..Bitter in the mouth, pungent; Warm in nature.Return lung; Liver Channel.Function drying dampness to eliminate phlegm; Relieving spasm by subduing liver-wind; Reducing swelling and alleviating pain.Main productive cough due to phlegm-damp; Dizziness due to wind-phlegm; Epilepsy; Apoplexy; Facial hemiparalysis; Tetanus; Carbuncle; Venom.

Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching calls large plumage crescent Herba pteridii latiusculi, Coniogramme japonica (Thunb.) Diels, derives from fern Athyriaceae Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching Abacopterismultilineata(Wall.) Ching, is used as medicine with root stock.Bitter in the mouth, cold in nature.Function dredge the meridian passage, dampness removing of regulating the flow of vital energy.Cure mainly impairment caused by overstrain, peratodynia, dysentery, menoxenia.

Herba Limnophilae rugosae another name Tian Gencao, water mint, Rhizoma begoniae pedatifidae, water Herba Schizonepetae, ripples perfume, wrinkle leaf Herba Limnophilae sessiliflorae are the herb of goatweed Limnophila rugosa NitellaexpansaAllen, Limnophilarugosa (Roth) Merr..Acrid in the mouth; Sweet; Warm in nature.Return lung; Spleen; Stomach warp.Function invigorating spleen to remove dampness; Activating QI to eliminate phlegm.Main edema; Stomachache; Distension and fullness of the chest and abdomen; Cough; Children's's infantile dyspepsia; Furuncle.

Radix Teucrii Pernyi another name Mount Lushan spice, derives from Labiatae and spends Phryganeajaponica Ml. TeucriumpernyiFranch. in vain, be used as medicine with root.Taste is micro-sweet, warm in nature.Function invigorating spleen to remove dampness, removing toxic substances.Cure mainly dysentery.

Herba lespedezae pilosae another name Herba cassiae torae, derives from pulse family Lespedeza plant Herba lespedezae pilosae Lespedezapilosa(Thunb.) Sieb. day Zucc., is used as medicine with root and Herb.Bitter in the mouth, pungent, property is put down.Function heat clearing away eliminating stagnation, promoting blood circulation and stopping pain, line water detumescence.For lymphoid tuberculosis, cold abscess, deficiency-heat is not moved back, edema, waist hamstring osteodynia; Mastitis are controlled in external.

Folium Coreopsis lanceolatae another name Coreopsis lanceolata, sword-like leave coreopsis, derive from Compositae Folium Coreopsis lanceolatae CoreopsislanceolataL., with all herbal medicine.Acrid in the mouth, property is put down.Function blood stasis dispersing and deswelling, heat-clearing and toxic substances removing.Cure mainly knife injury, innominate toxic swelling.

In medicine of the present invention, Chinese fanpalm seed blood circulation promoting and blood stasis dispelling, hard masses softening and resolving; Herba Lysionoti Pauciflori heat clearing and damp drying, reducing swelling and alleviating pain; Radix Pimpinellae Candolleanae promoting the circulation of QI to relieve pain, dissipating blood stasis for subsidence of swelling; Radix Pentasacmi championii falls apart wind heat clearing away, removing toxic substances and promoting subsidence of swelling; Rhizoma Arisaemati drying dampness to eliminate phlegm, reducing swelling and alleviating pain; Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching dredge the meridian passage, regulating QI to expel dampness; Herba Limnophilae rugosae, Radix Teucrii Pernyi invigorating spleen to remove dampness, activating QI to eliminate phlegm; Herba lespedezae pilosae heat clearing away eliminating stagnation, promoting blood circulation and stopping pain; Folium Coreopsis lanceolatae blood stasis dispersing and deswelling, heat-clearing and toxic substances removing.All medicines share, and play heat-clearing and toxic substances removing altogether, promoting blood circulation to remove obstruction in the collateral, blood stasis-eliminating and stagnation-dissipating, the effect of reducing swelling and alleviating pain.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

Treat a pharmaceutical composition for lower limb injury, each crude drug weight proportion is as follows:

Chinese fanpalm seed 60g, Herba Lysionoti Pauciflori 60g, Radix Pimpinellae Candolleanae 60g, Radix Pentasacmi championii 60g, Rhizoma Arisaemati 60g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 60g, Herba Limnophilae rugosae 60g, Radix Teucrii Pernyi 60g, Herba lespedezae pilosae 60g, Folium Coreopsis lanceolatae 60g.

Method of preparation and use: be ground into fine powder by after each composition Chinese medicine mixing of medicine of the present invention, for subsequent use.Get fine powder when using appropriate, mix well deposited affected part with water, tea, vinegar, Ovum Gallus domesticus album, vaseline or glycerol etc.

Embodiment 2

Treat a pharmaceutical composition for lower limb injury, each crude drug weight proportion is as follows:

Chinese fanpalm seed 50g, Herba Lysionoti Pauciflori 70g, Radix Pimpinellae Candolleanae 50g, Radix Pentasacmi championii 70g, Rhizoma Arisaemati 50g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 70g, Herba Limnophilae rugosae 50g, Radix Teucrii Pernyi 70g, Herba lespedezae pilosae 50g, Folium Coreopsis lanceolatae 70g.

Method of preparation and use is with embodiment 1.

Embodiment 3

Treat a pharmaceutical composition for lower limb injury, each crude drug weight proportion is as follows:

Chinese fanpalm seed 70g, Herba Lysionoti Pauciflori 50g, Radix Pimpinellae Candolleanae 70g, Radix Pentasacmi championii 50g, Rhizoma Arisaemati 70g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 50g, Herba Limnophilae rugosae 70g, Radix Teucrii Pernyi 50g, Herba lespedezae pilosae 70g, Folium Coreopsis lanceolatae 50g.

Method of preparation and use is with embodiment 1.

Embodiment 4

Treat a pharmaceutical composition for lower limb injury, each crude drug weight proportion is as follows:

Chinese fanpalm seed 40g, Herba Lysionoti Pauciflori 60g, Radix Pimpinellae Candolleanae 40g, Radix Pentasacmi championii 60g, Rhizoma Arisaemati 40g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 60g, Herba Limnophilae rugosae 40g, Radix Teucrii Pernyi 60g, Herba lespedezae pilosae 40g, Folium Coreopsis lanceolatae 60g.

Method of preparation and use is with embodiment 1.

Embodiment 5

Treat a pharmaceutical composition for lower limb injury, each crude drug weight proportion is as follows:

Chinese fanpalm seed 60g, Herba Lysionoti Pauciflori 40g, Radix Pimpinellae Candolleanae 60g, Radix Pentasacmi championii 40g, Rhizoma Arisaemati 60g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 40g, Herba Limnophilae rugosae 60g, Radix Teucrii Pernyi 40g, Herba lespedezae pilosae 60g, Folium Coreopsis lanceolatae 40g.

Method of preparation and use is with embodiment 1.

Carried out clinical pharrnacokinetics test to medicine of the present invention, Details as Follows:

L data and method

1.1 physical data choose lower limb injury patient 96 example, it are divided at random treatment group and each 48 examples of matched group, treatment group man 38 example, female 10 example.The median age 35 years old.Matched group man 36 example, female 12 example.The median age 36 years old.Two groups of patients compare not statistically significant (P>0.05) in sex, age etc., have comparability.

1.2 method

1.2.1 Therapeutic Method two groups of patients all give fluid infusion anti-inflammatory treatment.Matched group gives amoxicillin sulbactam sodium 3g and adds the input of normal saline 100ml medium-sized vein, every day 2 times.Treatment group on treatment of control group basis in conjunction with the pharmaceutical composition external application for curing of the embodiment of the present invention 1, method: first sterilize with chelated iodine in local, after dry; get the pharmaceutical composition 9g of the embodiment of the present invention 1; be placed in container; with appropriate white vaseline by medicine furnishing pasty state; dip in medicine stand with disposable pressure slabstone and spread on affected part, thickness is about 0.5-0.8cm, and area should be a bit larger tham focal zone; wrap up with sterile bandage; elasticity is moderate, immobilization with adhesive tape, and suffering limb foot-rest is raised 3O °-4O °; change dressings every day 1 time, within 1 week, is 1 course for the treatment of.

1.2.2 the curative effect of two groups of patients is observed in evaluation methodology, and criterion of therapeutical effect, with reference to " Chinese medical disease Standardization of diagnosis and curative effect ", is cured: whole body and local symptom disappear, and blood leukocytes is total and differential counting is normal; Effective: General Symptoms disappears, local symptom does not disappear entirely, and blood leukocytes sum and (or) differential counting decline and (or) normal; Invalid: symptom, sign are without improvement or increase the weight of.Record pain relieving time and the swelling remission time of two groups of patients.

1.2.3 statistical analysis adopts PEMS3.1 statistical software to analyze, the therapeutic effect of two groups of patients compares employing two independent sample Wilcoxon rank test, pain relieving time and swelling remission time compare employing two independent samples t test, inspection level α=0.05.

2 results

The therapeutic effect of 2.1 liang of group patients compares (table 1)

The therapeutic effect of table 1 liang group patient compares (example)

Group	Number of cases	Cure	Effectively	Invalid	Cure rate (%)	Total effective rate (%)
							Treatment group	48	46	2	0	95.83*	100.00*
Matched group	48	30	10	8	62.50	83.33

Note: compared with matched group, * P < 0.05.

2.2 liang of group patient pain remission times, swelling remission times compare (table 2)

Table 2 liang group patient pain remission time, swelling remission time compare (x ± s)

Group	Number of cases	Cure rate (%)	Total effective rate (%)
				Treatment group	48	3.69±1.82*	68.44±14.14**
Matched group	48	16.00±2.80	95.06±12.02

Note: compared with matched group, * P < 0.05, compared with matched group, * * P < 0.01.

Claims (3)

1. treat a pharmaceutical composition for lower limb injury, be made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 4-6 part, Herba Lysionoti Pauciflori 4-6 part, Radix Pimpinellae Candolleanae 4-6 part, Radix Pentasacmi championii 4-6 part, Rhizoma Arisaemati 4-6 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 4-6 part, Herba Limnophilae rugosae 4-6 part, Radix Teucrii Pernyi 4-6 part, Herba lespedezae pilosae 4-6 part, Folium Coreopsis lanceolatae 4-6 part.

2. the pharmaceutical composition for the treatment of lower limb injury according to claim 2, is characterized in that, is made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 5-7 part, Herba Lysionoti Pauciflori 5-7 part, Radix Pimpinellae Candolleanae 5-7 part, Radix Pentasacmi championii 5-7 part, Rhizoma Arisaemati 5-7 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 5-7 part, Herba Limnophilae rugosae 5-7 part, Radix Teucrii Pernyi 5-7 part, Herba lespedezae pilosae 5-7 part, Folium Coreopsis lanceolatae 5-7 part.

3. the pharmaceutical composition for the treatment of lower limb injury according to claim 2, is characterized in that, is made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 6 parts, Herba Lysionoti Pauciflori 6 parts, Radix Pimpinellae Candolleanae 6 parts, Radix Pentasacmi championii 6 parts, Rhizoma Arisaemati 6 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 6 parts, Herba Limnophilae rugosae 6 parts, Radix Teucrii Pernyi 6 parts, Herba lespedezae pilosae 6 parts, Folium Coreopsis lanceolatae 6 parts.