CN104491052B - Traditional Chinese medicine composition for treating rheumatic and rheumatoid arthritis and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating rheumatic and rheumatoid arthritis and preparation method thereof Download PDF

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CN104491052B
CN104491052B CN201410802352.9A CN201410802352A CN104491052B CN 104491052 B CN104491052 B CN 104491052B CN 201410802352 A CN201410802352 A CN 201410802352A CN 104491052 B CN104491052 B CN 104491052B
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radix
chinese medicine
rheumatoid arthritis
traditional chinese
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香兴福
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SHAANXI BICON PHARMACEUTICAL GROUP HOLDING Co Ltd
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Abstract

The invention discloses a traditional Chinese composition for treating rheumatic and rheumatoid arthritis. The traditional Chinese composition is prepared from the following components in parts by weight: 40-45 parts of radix aconiti preparata, 40-45 parts of radix aconiti kusnezoffii, 30-35 parts of rhizoma et radix notopterygii, 30-35 parts of radix angelicae pubescentis, 4-8 parts of radix aconiti lateralis preparata, 13-16 parts of myrrha, 30-35 parts of radix angelicae sinensis, 30-35 parts of radix cyathulae, 25-28 parts of fructus chaenomelis, 18-22 parts of ephedra, 18-22 parts of ramulus cinnamomi, 48-55 parts of scolopendra, 23-26 parts of ligusticum wallichii and 50-55 parts of prepared nux vomica. A preparation method disclosed by the invention comprises the following steps: decocting radix angelicae sinensis, radix cyathulae, fructus chaenomelis, ephedra, ramulus cinnamomi and ligusticum wallichii to obtain a filtrate, filtering and concentrating the filtrate into an ointment; mixing and pelletizing the other crushed components with the ointment; and then straightening, tabletting and coating, so as to obtain the traditional Chinese medicine tablets for treating rheumatic and rheumatoid arthritis. The traditional Chinese medicine composition disclosed by the invention solves the problems of being large in side effects, and hard to eradicate, and easily causes drug resistance. Aiming to various causes of rheumatic and rheumatoid arthritis, the traditional Chinese medicine has a good curative effect.

Description

Chinese medicine composition for the treatment of rheumatism and rheumatoid arthritis and preparation method thereof
Technical field
The invention belongs to drug preparation technique field, is related to a kind of Chinese traditional medicine composition for treating rheumatism and rheumatoid arthritis Thing, the invention further relates to the preparation method of the Chinese medicine composition.
Background technology
Rheumatism, rheumatoid arthritis are chronic, intractable common disease, frequently-occurring disease, are mainly shown as migrans, symmetrical Property, recurrent.Clinical manifestation is arthroncus or migrans pain, extremity numbness, dysarthrasis.Rheumatic arthritis is rheumatism One of main performance of heat, to be grown up as common, typical performance is slight or moderate heating, and migratory polyarthritis, involvement is closed Section mostly is the large joints such as knee, ankle, shoulder, elbow, wrist, is secondly that the Minor articulus of shoulder, elbow and wrist, hand and foot are rarely found.It is common by one Joint is transferred to another joint, and pathology local is presented red, swollen, scorching hot, severe pain, and some patients also have several joints to send out simultaneously Disease.Typical patient only has arthralgia and without other inflammation performances, acute inflammation typically disappeared in 2～4 weeks, lost after not staying Disease, but often recurrent exerbation.If active rheumatism affects heart, myocarditis can occur, or even leave valve disorder.
Rheumatoid arthritis is a kind of chronic generalized autoimmune disease being characterized with arthrosynovitis.Synovial membrane Scorching persistently recurrent exerbation, can cause the destruction of cartilage and bone in joint, joint function disturbance, or even maimed person, pathology to involve whole body Each organ.Rheumatoid arthritis is apt to occur in the Minor articulus such as hand, wrist, foot, and recurrent exerbation is symmetric.There is joint early stage Red and swollen heat pain and dysfunction, also can invade and other size joints, and advanced joint may occur in which different degrees of stiff deformity, and companion There is the atrophy of bone and skeletal muscle, easily disable.Rheumatoid arthritis journey length, disability rate are high, mostly sudden onset, invisible It is stronger.
Rheumatic arthritis is considered as a kind of allergic disease relevant with hemolytic streptococcal infection, rheumatoid Property arthritis is then a kind of agnogenic autoimmune disease.Theory of traditional Chinese medical science thinks the limbs pain caused by wind, cold, wet Or it is numb, mainly by wind, it is wet, cold take advantage of a weak point, caused by stream joint in channels and collaterals, obstruction qi and blood.Wherein rheumatoid is by some The autoimmunity that infectious diseases is caused causes the arthropathy based on synovial membrane.At present to rheumatic and rheumatoid joint Adopting Western medicine therapy, western medicine although to have more satisfactory anti-inflammatory analgesic effect scorching treatment more, but can not be fundamentally Improve pathology, symptom again can repeatedly after drug withdrawal, and long-term prescription can produce bad reaction and toxic and side effect, to lesions of liver and kidney compared with Greatly, it is difficult to adhere to long-term treatment mostly, and the resistance to the action of a drug occurs.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for treating rheumatism and rheumatoid arthritis, solves Western medicine Treatment side effect is big, be difficult to eradicate, drug-fast problem occurs.
It is a further object to provide the preparation method of above-mentioned Chinese medicine composition.
The technical solution adopted in the present invention is：The Chinese medicine composition for the treatment of rheumatism and rheumatoid arthritis, by quality Percentage is made up of following component：It is made up of following component according to parts by weight：40～45 parts of aconiti preparata,radix, wild aconite root 40～45 Part, 30～35 parts of notopterygium root, 30～35 parts of levisticum, 4～8 parts of monkshood, 13～16 parts of frankincense, 13～16 parts of myrrh, Radix Angelicae Sinensis 30～35 Part, 30～35 parts of radix cyathulae, 25～28 parts of pawpaw, 18～22 parts of Chinese ephedra, 18～22 parts of cassia twig, 48～55 parts of centipede, Ligusticum wallichii 23 ～26 parts, 50～55 parts of prepared nux vomica.
Preferably, it is made up of following component according to parts by weight：42 parts of aconiti preparata,radix, 42 parts of wild aconite root, 32 parts of notopterygium root, levisticum 32 parts, 6 parts of monkshood, 15 parts of frankincense, 15 parts of myrrh, 32 parts of Radix Angelicae Sinensis, 32 parts of radix cyathulae, 25 parts of pawpaw, 20 parts of Chinese ephedra, cassia twig 20 Part, 50 parts of centipede, 25 parts of Ligusticum wallichii, 50 parts of prepared nux vomica.
Another technical scheme of the present invention is that the preparation method of above-mentioned Chinese medicine composition is comprised the following steps： Step 1：By weight fraction weighs respectively following raw material：40～45 parts of aconiti preparata,radix, 40～45 parts of wild aconite root, 30～35 parts of notopterygium root, 30～35 parts of levisticum, 4～8 parts of monkshood, 13～16 parts of frankincense, 13～16 parts of myrrh, 30～35 parts of Radix Angelicae Sinensis, radix cyathulae 30～35 Part, 25～28 parts of pawpaw, 18～22 parts of Chinese ephedra, 18～22 parts of cassia twig, 48～55 parts of centipede, 23～26 parts of Ligusticum wallichii, prepared nux vomica 50～55 parts；
Step 2：After Radix Angelicae Sinensis that step 1 is weighed, radix cyathulae, pawpaw, Chinese ephedra, cassia twig, Ligusticum wallichii are cleaned plus 8-10 times of decocting Boil secondary, 3 hours every time, merge 2 decoction liquors, after staticly settling, filter to get filtrate, filter residue is discarded；
Step 3：The filtrate reduced in volume that step 2 is obtained is the ointment that relative density is 1.30～1.33 under room temperature；
Step 4：Mixing granulation
Using efficient mixer-granulator wet granulation, after remaining Chinese medicinal component in step 1 is crushed 100-120 mesh sieves are crossed And sterilize, the maltose for adding relative its quality summation 15% is mixed, and the ointment that step 3 is obtained then is added, with 65% sugar Slurry is pelletized as adhesive and is dried；
Step 5：Particle obtained in step 4 is crossed into 12 mesh sieves, using Fastgranulatemachine whole grain, particle moisture control 4～ 5%, grain amount is 60～70%, the particle and talcum powder after whole grain, and magnesium stearate is according to mass ratio 325:4:1.3 add three-dimensional In movement mixer, mix 30 minutes；Then compressing tablet and coating are carried out, tablet is obtained.
Of the invention the characteristics of, also resides in,
Step 2 is filtered and uses 100～200 mesh sieve net filtrations.
The pressure concentrated in step 3 is -0.06～-0.075MPa, and thickening temperature is 55～60 DEG C.
Granulation in step 4 is pelletized with 14 mesh nylon screens.
Drying in step 4 is dried using boiling drier, fluidized bed drying room temperature≤80 DEG C；Dried particle Moisture content≤4%.
Compressing tablet adopts rotary tablet machine, rotating speed to be less than 36 revs/min in step 5.
In step 5 coating adopt syrup configuration proportion for：60 parts of sucrose adds water 39 parts the simple syrup for being configured to 65.3%；Glue Syrup configuration proportion：24 parts of white sugar, 1.06 parts of gelatin, 10 parts of water；Insect wax configuration proportion：2 parts of insect wax, 40 parts of silicone oil；Mill base is pressed 1g pigments add the ratio of 10～20ml of purified water to be prepared, and heating is boiled to be added in 1000～1500ml simple syrups after filtration and added Heat is boiled and is stirred, and should accomplish a small amount of multiple, is dried layer by layer.
The invention has the beneficial effects as follows：The Chinese medicine composition of present invention treatment rheumatism and rheumatoid arthritis, all medicines are closed With with kidney tonifying dispelling cold, dampness elimination dispelling wind, blood stasis and smoothing collaterals living, the effect for strengthening muscles and bones improves human body immune function, evident in efficacy, nothing Side effect, it is safe, be conducive to patient to mitigate symptom in time, western medicine large side effects are solved, is difficult to eradicate, occurred Drug-fast problem, the rheumatic caused for the various causes of disease and rheumatoid arthritis have good efficacy.
Specific embodiment
With reference to specific embodiment, the present invention is described in detail.
First, the prescription and content of Chinese medicine composition of the invention
The Chinese medicine composition of present invention treatment rheumatism and rheumatoid arthritis, according to parts by weight by following component group Into：40～45 parts of aconiti preparata,radix, 40～45 parts of wild aconite root, 30～35 parts of notopterygium root, 30～35 parts of levisticum, 4～8 parts of monkshood, frankincense 13 ～16 parts, 13～16 parts of myrrh, 30～35 parts of Radix Angelicae Sinensis, 30～35 parts of radix cyathulae, 25～28 parts of pawpaw, 18～22 parts of Chinese ephedra, osmanthus 18～22 parts of branch, 48～55 parts of centipede, 23～26 parts of Ligusticum wallichii, 50～55 parts of prepared nux vomica.
The preparation method of above-mentioned Chinese medicine composition, comprises the following steps：
Step 1：By weight fraction weighs respectively following raw material：40～45 parts of aconiti preparata,radix, 40～45 parts of wild aconite root, notopterygium root 30 ～35 parts, 30～35 parts of levisticum, 4～8 parts of monkshood, 13～16 parts of frankincense, 13～16 parts of myrrh, 30～35 parts of Radix Angelicae Sinensis, radix cyathulae 30～35 parts, 25～28 parts of pawpaw, 18～22 parts of Chinese ephedra, 18～22 parts of cassia twig, 48～55 parts of centipede, 23～26 parts of Ligusticum wallichii, horse 50～55 parts of money powder；
Step 2：After Radix Angelicae Sinensis that step 1 is weighed, radix cyathulae, pawpaw, Chinese ephedra, cassia twig, Ligusticum wallichii are cleaned plus 8-10 times of decocting Boil secondary, 3 hours every time, merge 2 decoction liquors, after staticly settling, filtered to get filtrate with 100～200 mesh stainless steel mesh, filter Slag is discarded；
Step 3：The filtrate reduced in volume that step 2 is obtained is the ointment that relative density is 1.30～1.33 under room temperature, dense The pressure of contracting is -0.06～-0.075MPa, and thickening temperature is 55～60 DEG C；
Step 4：Mixing granulation
Using efficient mixer-granulator wet granulation, after remaining Chinese medicinal component in step 1 is crushed 100-120 mesh sieves are crossed And sterilize, the maltose for adding relative its quality summation 15% is mixed, and the ointment that step 3 is obtained then is added, with 65% sugar Slurry is pelletized as adhesive with 14 mesh nylon screens, is dried using boiling drier, fluidized bed drying room temperature≤80 ℃；Dried particle moisture content≤4%；
Step 5：Particle obtained in step 4 is crossed into 12 mesh sieves, using Fastgranulatemachine whole grain, particle moisture control 4～ 5%, grain amount is 60～70%, the particle and talcum powder after whole grain, and magnesium stearate is according to mass ratio 325:4:1.3 add three-dimensional In movement mixer, mix 30 minutes；Then compressing tablet and coating are carried out, tablet is obtained.
Preferably, compressing tablet adopts rotary tablet machine, and rotating speed less than 36 revs/min being advisable；
Preferably, coating adopt syrup configuration proportion for：The ㎏ of sucrose 60 add water 39 ㎏ be configured to 65.3% simple syrup；Glue Syrup configuration proportion：The ㎏ of white sugar 24, the ㎏ of gelatin 1.06, the ㎏ of water 10；Insect wax configuration proportion：The ㎏ of insect wax 2, silicone oil 40ml；Mill base is pressed 1g pigments add the ratio of 10～20ml of purified water to be prepared, and heating is boiled to be added in 1000～1500ml simple syrups after filtration and added Heat is boiled and is stirred, and should accomplish a small amount of multiple, is dried layer by layer.
2nd, each prescription function and indication
1st, the present invention in each component function：
Aconiti preparata,radix：Pungent, hardship, heat；The thoughts of returning home, liver,kidney,spleen Jing, dispelling wind and eliminating dampness, antalgic.For wind-cold-dampness arthralgia, arthritis Bitterly, trusted subordinate's crymodynia, cold hernia is had a pain, narcotic analgesic；Wild aconite root：Pungent, hardship, heat；The thoughts of returning home, liver,kidney,spleen Jing；Dispelling wind and eliminating dampness, Wen Jingzhi Bitterly, for wind-cold-dampness arthralgia, arthralgia, trusted subordinate's crymodynia, cold hernia is had a pain, narcotic analgesic；Notopterygium root：Taste is pungent；It is bitter；It is warm in nature；Enter bladder, Kidney channel；Scattered exterior cold；Wines used as antirheumatic；Sharp joint；Relieving exterior syndrome and dispelling cold, expelling wind and eliminating dampness, pain relieving；Levisticum：Pungent, hardship, tepor.Return liver, kidney, bladder Jing；Expelling wind and eliminating dampness, eliminating cold to stop pain, for wind-cold-dampness arthralgia, lumbocrural pain；It is altogether monarch drug in a prescription.
Monkshood：With recuperating depleted yang, mends fire supporing yang, the effect of by wind-cold damp pathogen；Frankincense：It is warm in nature, for pain relieving, stagnation resolvation, Promoting blood circulation；Myrrh：It is promoting blood circulation and removing blood stasis, the effects such as have promoting blood circulation and stopping pain, detumescence and promoting granulation；Radix Angelicae Sinensis：It is sweet, it is pungent, it is bitter, it is warm in nature；Return liver, the heart, spleen Jing；With enriching blood, invigorate blood circulation, menstruction regulating and pain relieving, the effect of moisturize laxation；Radix cyathulae：Sweet, slight bitter, puts down.Return liver and kidney channel；It is logical by the stasis of blood Jing, easing joint movement, inducing diuresis for treating strangurtia；It is altogether ministerial drug.
Cassia twig：Acrid, sweet, warm.The thoughts of returning home, lung, bladder warp；Sweating expelling pathogenic factors from muscles and skin, warming meridians and promoting circulation of qi, helps yang transforming qi, eliminating cold to stop pain；Wu Centipede：It is pungent, temperature；Return liver warp；Ceases wind antispastic, dispersing pathogen accumulation is removed obstruction in channels to relieve pain.For child convulsion, tic spasm, middle air port is askew, and half Body is unsuccessful, lockjaw, rheumatoid arthritis stubborn, sore, scrofula, venomous snake bite；Ligusticum wallichii：Taste is pungent, it is warm in nature.Return liver, courage, pericardium channel；Promoting blood circulation Dissolving stasis, promote breath and open depression, wind-expelling pain-stopping；Prepared nux vomica：Property it is bitter, tremble with fear；Return liver, the Jing of spleen two；Remove obstruction in channels to relieve pain, with control rheumatoid arthritis stubborn or arrest Contraction is numb, dispersing swelling and dissipating binds；It is altogether adjutant.
Pawpaw：It is mild-natured, be slightly cold, it is sweet；Return liver, the spleen channel；It is aid digestion, relieve summer heat and quench one's thirst, moisten the lung and relieve the cough；Chinese ephedra：Pungent, slight bitter, Temperature；Return lung, bladder warp；Sweating cold dispelling, freeings lung and relieving asthma, inducing diuresis for removing edema；It is altogether to make medicine.
The traditional Chinese medical science thinks that rheumatoid arthritis is damp and hot to hand over resistance, stream to stay joint and fall ill, the day because wind-heat damp evil is invaded Do not heal long, cause the insufficiency of both the spleen and the kindey, table to defend not solid, susceptible exopathogen causes the illness recurrent exerbation state of an illness increasingly serious.We follow monarch The combination principle that minister assistant makes, full side's expelling wind and clearing away heat, dampness removing and network are with logical numbness, the Wen Yang on the basis of saturating table heat-clearing, dampness elimination dredging collateral , so as to reach giving consideration to both the incidental and fundamental, the evil purpose of righting method, full side's legislation is rigorous, and hit the interpretation of the cause, onset and process of an illness for beneficial gas.All medicines share, dispels with kidney tonifying Cold, dampness elimination dispelling wind, blood stasis and smoothing collaterals living, the effect for strengthening muscles and bones, multi-medicament suitably coordinates, using its mutual collaboration or opposing Effect, improves curative effect, reduces bad reaction, evident in efficacy, safe and reliable, so as to reach treatment rheumatic and rheumatoid joint Scorching purpose.
2nd, indication：
Dispel pathogenic wind and remove dampness, cold dispelling promoting blood circulation is relaxed the muscles and stimulate the blood circulation, and is removed obstruction in channels to relieve pain, diminishing inflammation and resolving masses, by broken product of becoming silted up, nourishing the liver and kidney.For controlling Treat swollen joint pain or migrans pain, extremity numbness, joint that acute and chronic rheumatic arthritis and rheumatoid arthritis cause The joint rheumatism such as deformation and the miserable numbness in joint, chilly foul wind, Ambulatory Activity inconvenience.
3rd, usage：
Orally, one time 3,3 times a day, warm water delivery service.It is within 7 days a course for the treatment of.
3rd, pharmacodynamic experiment
1. animal used as test：
Pure lines Kunming small white mouse 60, all females, body weight 20g～24g or so, before test adaptability feed 1 week (by Xi'an Jiaotong University Medical College's animal experimental center is provided).
2. experimental technique
By particle obtained in the step 4 of the embodiment of the present invention 2, every milliliter of liquid 0.5g containing raw medicinal herbs (small dose group) is made, The liquid of 3.2g (middle dose group), 6g (heavy dose of group).60 animals are randomly divided into 5 groups per group 12, true with way of drawing lots It is set to, A groups：Blank control group；B groups：Chinese medicine composition small dose group of the present invention；C groups：Chinese medicine composition middle dosage of the present invention Group；D groups：Chinese medicine composition heavy dose group of the present invention；E groups：Aspirin group (dosage：100mg/kg).
3. it is administered and feeding method
Daily gastric infusion 1 time after packet, A groups fill physiological saline 0.5ml/ only, and B groups fill little dose of Chinese medicine composition of the present invention Only, C groups fill Chinese medicine composition middle dosage liquid 0.5ml/ of the present invention only to medicine amount liquid 0.5ml/, and D groups fill Chinese medicine composition of the present invention Only, E groups fill aspirin aqueous solution 0.5ml/ only to heavy dose of liquid 0.5ml/, continuous use 12 days.All animals are provided with mark Quasi- feed and clean water, freely absorb, natural light irradiation.During to mouse stomach, mouse has no adverse reaction and death condition Occur.
4. detection project：
4.1 lick sufficient time gavage selects 55 ± 1 DEG C on 11st with constant water bath box, and 30s interior energies lick sufficient mouse on hot plate, Per group of each 12 whole is chosen, and continues gastric infusion, and difference 2 hours upon administration determines mouse and pain occurs on hot plate Time (licks foot as mark) with mouse.
After last time administration 45min, each group mouse peritoneal injection concentration is 0.6% acetic acid to 4.2 writhing number of times mouse Solution 0.2ml/ only, records the number of times of writhing in 15 minutes.
5. result of the test
5.1 five groups of ordinary circumstance mouse at the 1st～11 day of gastric infusion, activity, diet, the state of mind, hair color and body Weight Non Apparent Abnormality change, no significant difference between each group.Observation in 12nd day compare before hot plate method analgesic experiment also indifference with doing.
The impact that 5.2 Chinese medicine compositions of the present invention are tested mouse hot-plate：
The mouse hot-plate result of the test of table 1
Group Number of animals (only) Lick sufficient time (s)
Blank control group (A) 12 23.3
Chinese medicine composition low dose (B) 12 28.6
Chinese medicine composition middle dosage (C) 12 36.2
Chinese medicine composition heavy dose (D) 12 43.6
Aspirin group (E) 12 44.5
Compared with blank control group, p value<0.05, p value represents statistical value.
5.3 Chinese medicine composition Dichlorodiphenyl Acetates to mouse writhing reaction impact：
The each group Dichlorodiphenyl Acetate of table 2 institute is to mouse writhing reaction test result
Group Number of animals (only) Writhing number of times
Blank control group (A) 12 47.9
Chinese medicine composition low dose (B) 12 36.6
Chinese medicine composition middle dosage (C) 12 32.5
Chinese medicine composition heavy dose (D) 12 28.7
Aspirin group (E) 12 28.3
Compared with blank control group, p value<0.05, p value represents statistical value.
Tested by above-mentioned hot plate method in mice and mouse writhing method, Chinese medicine composition of the present invention can reduce mouse acetic acid institute The writhing number of times for causing, and extend mouse hot-plate and cause and lick the sufficient time, illustrate that Chinese medicine composition of the present invention has obvious anti-inflammatory town Pain is acted on, and for the swollen joint pain that clinical remission rheumatic arthritis and rheumatoid arthritis cause experimental basis are provided.
4th, clinical trial
1st, conditions of patients and basic condition：
Altogether clinical observation treatment is carried out to 540 rheumatic and rheumatoid arthritis out-patient, wherein, man 180, Female 360, the oldest 78 years old, minimum 26 years old, average age 45 years old.
2nd, treatment method：
Chinese medicine composition tablet prepared by the oral embodiment of the present invention 2, takes points early, middle and late for three times, one time 3, Wen Kai Water delivery service.It is within 7 days a course for the treatment of.
3rd, criterion of therapeutical effect：
Cure：Clinical symptom and sign disappears, and recovers normal；It is effective：Clinical symptom and sign substantially or mostly disappears；Have Effect：Clinical symptoms are clearly better；It is invalid：Clinical symptom and sign is without improvement.
4th, treatment results：
Treatment time is calculated according to conditions of patients weight, taking 1 course for the treatment of just can win initial success, and patients with mild takes 4 Course for the treatment of or so can fully recover, and severe patient takes 10 courses for the treatment of can fully recover.In 540 patients, clinical cure 388 accounts for 72%； Effective 70, account for 13%；Effective 59, account for 11%；Invalid 23, total effective rate 96%.
Embodiment 1
Step 1：By weight fraction weighs respectively following raw material：Aconiti preparata,radix 40g, wild aconite root 45g, notopterygium root 35g, levisticum 30g, Monkshood 4g, frankincense 16g, myrrh 13g, Radix Angelicae Sinensis 30g, radix cyathulae 35g, pawpaw 26g, Chinese ephedra 18g, cassia twig 22g, centipede 48g, Ligusticum wallichii 26g, prepared nux vomica 55g；
Step 2：After Radix Angelicae Sinensis that step 1 is weighed, radix cyathulae, pawpaw, Chinese ephedra, cassia twig, Ligusticum wallichii are cleaned plus 8 times of decoctings boil two It is secondary, 3 hours every time, merge 2 decoction liquors, after staticly settling, filtered to get filtrate with 100 mesh stainless steel mesh, filter residue is discarded；
Step 3：The filtrate reduced in volume that step 2 is obtained is the ointment that relative density under room temperature is 1.30, the pressure of concentration It is by force -0.06MPa, thickening temperature is 60 DEG C；
Step 4：Mixing granulation
Using efficient mixer-granulator wet granulation, 100 mesh sieves are crossed after remaining Chinese medicinal component in step 1 is crushed and is gone out Bacterium, the maltose for adding relative its quality summation 15% is mixed, and then adds the ointment that step 3 is obtained, and is made with 65% syrup For adhesive, pelletized with 14 mesh nylon screens, be dried using boiling drier, fluidized bed drying room temperature≤80 DEG C；It is dry Particle moisture content≤4% after dry；
Step 5：Particle obtained in step 4 is crossed into 12 mesh sieves, using Fastgranulatemachine whole grain, particle moisture control 4%, Grain amount is 60%, the particle and talcum powder after whole grain, and magnesium stearate is according to mass ratio 325:4:1.3 add three-dimensional motion mixing In machine, mix 30 minutes；Then compressing tablet and coating are carried out, tablet is obtained.
Embodiment 2
Step 1：Following component is weighed respectively according to parts by weight：Aconiti preparata,radix 42g, wild aconite root 42g, notopterygium root 32g, levisticum 32g, monkshood 6g, frankincense 15g, myrrh 15g, Radix Angelicae Sinensis 32g, radix cyathulae 32g, pawpaw 25g, Chinese ephedra 20g, cassia twig 20g, centipede 50g, Ligusticum wallichii 25g, prepared nux vomica 50g；
Step 2：After Radix Angelicae Sinensis that step 1 is weighed, radix cyathulae, pawpaw, Chinese ephedra, cassia twig, Ligusticum wallichii are cleaned plus 10 times of decoctings are boiled It is secondary, 3 hours every time, merge 2 decoction liquors, after staticly settling, filtered to get filtrate with 200 mesh stainless steel mesh, filter residue is discarded；
Step 3：The filtrate reduced in volume that step 2 is obtained is the ointment that relative density under room temperature is 1.33, the pressure of concentration It is by force -0.075MPa, thickening temperature is 55 DEG C；
Step 4：Mixing granulation
Using efficient mixer-granulator wet granulation, 120 mesh sieves are crossed after remaining Chinese medicinal component in step 1 is crushed and is gone out Bacterium, the maltose for adding relative its quality summation 15% is mixed, and then adds the ointment that step 3 is obtained, and is made with 65% syrup For adhesive, pelletized with 14 mesh nylon screens, be dried using boiling drier, fluidized bed drying room temperature≤80 DEG C；It is dry Particle moisture content≤4% after dry；
Step 5：Particle obtained in step 4 is crossed into 12 mesh sieves, using Fastgranulatemachine whole grain, particle moisture control 5%, Grain amount is 70%, the particle and talcum powder after whole grain, and magnesium stearate is according to mass ratio 325:4:1.3 add three-dimensional motion mixing In machine, mix 30 minutes；Then compressing tablet and coating are carried out, tablet is obtained.
Embodiment 3
Step 1：Following component is weighed respectively according to parts by weight：Aconiti preparata,radix 45g, wild aconite root 40g, notopterygium root 30g, levisticum 35g, monkshood 8g, frankincense 13g, myrrh 16g, Radix Angelicae Sinensis 35g, radix cyathulae 30g, pawpaw 28g, Chinese ephedra 22g, cassia twig 18g, centipede 55g, Ligusticum wallichii 23g, prepared nux vomica 52g；
Step 2：After Radix Angelicae Sinensis that step 1 is weighed, radix cyathulae, pawpaw, Chinese ephedra, cassia twig, Ligusticum wallichii are cleaned plus 9 times of decoctings boil two It is secondary, 3 hours every time, merge 2 decoction liquors, after staticly settling, filtered to get filtrate with 150 mesh stainless steel mesh, filter residue is discarded；
Step 3：The filtrate reduced in volume that step 2 is obtained is the ointment that relative density under room temperature is 1.32, the pressure of concentration It is by force -0.07MPa, thickening temperature is 58 DEG C；
Step 4：Mixing granulation
Using efficient mixer-granulator wet granulation, 110 mesh sieves are crossed after remaining Chinese medicinal component in step 1 is crushed and is gone out Bacterium, the maltose for adding relative its quality summation 15% is mixed, and then adds the ointment that step 3 is obtained, and is made with 65% syrup For adhesive, pelletized with 14 mesh nylon screens, be dried using boiling drier, fluidized bed drying room temperature≤80 DEG C；It is dry Particle moisture content≤4% after dry；
Step 5：Particle obtained in step 4 is crossed into 12 mesh sieves, using Fastgranulatemachine whole grain, particle moisture control exists 4.5%, grain amount is 65%, the particle and talcum powder after whole grain, and magnesium stearate is according to mass ratio 325:4:1.3 add three maintenance and operations In dynamic mixer, mix 30 minutes；Then compressing tablet and coating are carried out, tablet is obtained.
The present invention provides a kind of method that the Chinese medicine composition is prepared as into tablet, but restriction can only not adopt this kind of side Prepared by method, do not constitute the restriction to the Chinese medicine composition formulation and preparation method, and other methods well known in the art may also be employed To prepare different formulations, such as ointment, pill, capsule, pulvis common formulations.

Claims (2)

1. the preparation method of the Chinese medicine composition of rheumatism and rheumatoid arthritis is treated, it is characterised in that comprised the following steps：
Step 1：Weigh following raw material respectively by weight：40～45 parts of aconiti preparata,radix, 40～45 parts of wild aconite root, notopterygium root 30～ 35 parts, 30～35 parts of levisticum, 4～8 parts of monkshood, 13～16 parts of frankincense, 13～16 parts of myrrh, 30～35 parts of Radix Angelicae Sinensis, radix cyathulae 30 ～35 parts, 25～28 parts of pawpaw, 18～22 parts of Chinese ephedra, 18～22 parts of cassia twig, 48～55 parts of centipede, 23～26 parts of Ligusticum wallichii, Strychnos nux-vomica 50～55 parts of sub- powder；
Step 2：After Radix Angelicae Sinensis that step 1 is weighed, radix cyathulae, pawpaw, Chinese ephedra, cassia twig, Ligusticum wallichii are cleaned plus 8-10 times of decocting boils two It is secondary, 3 hours every time, merge 2 decoction liquors, after staticly settling, filter to get filtrate, filter residue is discarded；
Step 3：The filtrate reduced in volume that step 2 is obtained is the ointment that relative density is 1.30～1.33 under room temperature；Concentration Pressure is -0.06～-0.075MPa, and thickening temperature is 55～60 DEG C；
Step 4：Mixing granulation
Using efficient mixer-granulator wet granulation, 100-120 mesh sieves are crossed simultaneously after remaining traditional Chinese medicinal components in step 1 are crushed Sterilizing, the maltose for adding relative its quality summation 15% is mixed, and the ointment that step 3 is obtained then is added, with 65% syrup Pelletized as adhesive and be dried using boiling drier, fluidized bed drying room temperature≤80 DEG C；Dried Grain moisture≤4%；14 mesh nylon screens are adopted during granulation；
Step 5：Particle obtained in step 4 is crossed into 12 mesh sieves, using Fastgranulatemachine whole grain, pellet moisture is controlled 4～5%, Grain amount is 60～70%, the particle and talcum powder after whole grain, and magnesium stearate is according to mass ratio 325:4:1.3 add three-dimensional motion In mixer, mix 30 minutes；Then compressing tablet and coating are carried out, compressing tablet adopts rotary tablet machine, rotating speed to be less than 36 revs/min Clock；Coating adopt syrup configuration proportion for：Sucrose is configured to 65.3% simple syrup；Glycocoll starches configuration proportion：It is 24 parts of white sugar, bright 1.06 parts of glue, 10 parts of water；Insect wax configuration proportion：2 parts of insect wax, 40 parts of silicone oil；Mill base adds 10～20ml's of purified water by 1g pigments Ratio is prepared, and heating to be boiled add after filtration to heat to boil in 1000～1500ml simple syrups and stirred, and should accomplish few Amount is multiple, is dried layer by layer；Tablet is finally obtained.
2. the preparation method of the Chinese medicine composition of rheumatism and rheumatoid arthritis, its feature are treated as claimed in claim 1 It is that the step 2 is filtered and uses 100～200 mesh sieve net filtrations.
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