CN103751309A - Traditional Chinese medicine external preparation for treating intercostal neuralgia and preparation method thereof - Google Patents
Traditional Chinese medicine external preparation for treating intercostal neuralgia and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine external preparation for treating intercostal neuralgia, which is prepared from the following raw materials in parts by weight: 10-20 parts of cowherb seed, 10-20 parts of frankincense, 10-20 parts of myrrh, 10-20 parts of toosendan fruit, 10-20 parts of spatholobus stem, 10-20 parts of hemlock parsley, 10-20 parts of red paeonia, 10-20 parts of radix sileris, 10-20 parts of pseudo-ginseng, 10-20 parts of angelica, 10-20 parts of safflower, 10-20 parts of corydalis tuber, 10-20 parts of herba schizonepetae, 10-20 parts of radix salviae miltiorrhizae, 10-20 parts of radix clematidis, 10-20 parts of ground beetle, 10-20 parts of lumbricus and 10-20 parts of herba artemisiae. The traditional Chinese medicinal materials with different properties are utilized to go direct to the focus of the disease; and the traditional Chinese medicine external preparation has the effects of tonifying qi and blood, activating blood circulation to dissipate blood stasis, removing slough and promoting growth of tissue regeneration. The preparation can improve the partial blood capillary obstacles and enable the necrotic tissues to quickly shed, thereby achieving the goal of restoring the tissues; the preparation can prevent infection and enhance the immunologic functions of the organisms; and when being applied externally, the preparation can effectively improve the circulation, has the strong and enduring anti-inflammatory action, and is capable of inhibiting infectious and non-infectious inflammation, reducing the congestion and lowering the permeability of capillary vessels.
Description
Technical field
The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, particularly a kind of Chinese medicine for external application for the treatment of intercostal neuralgia and preparation method thereof.
Background technology
Intercostal neuralgia refers to the regular pain in one or a few intercostal nerves domination district.Intercostal nerves has 12 pairs, after being sent by breast marrow through front and after root associating and forming.Before thoracic nerves is divided into, rear, meningeal branch and communicating branch.Front is called intercostal nerves between the inside and outside pleural muscle of intercostal, and traveling is below intercostal arteries.Intercostal neuralgia refers to the regular pain that one or several intercostal position occurs, and has ictal aggravation.Constitutional intercostal neuralgia is seldom shown in, the many and viral infection of Secondary cases person, and toxin stimulates, and mechanical damage and foreign body compressing etc. are relevant.Its characteristic of pain mostly is twinge or causalgia, and distributes along intercostal nerves.
What conventionally see clinically is Secondary cases intercostal neuralgia, and constitutional intercostal neuralgia is more rare.Secondary cases intercostal neuralgia is to be caused by the pathological changes of adjacent organs and tissue, as the pathological changes of thoracic organs (pleuritis, chronic pneumonia, aortic aneurysm etc.), the damage of spinal column and rib, senile vertebra osteoarthritis, the deformity of thoracic vertebra section spinal column, the outer tumor of thoracic vertebra section tumor of spinal cord, particularly marrow, normal pressuring neural root and have the symptom of intercostal neuralgia., also can there is intercostal neuralgia in the intercostal nerves inflammation that also has a kind of varicella zoster virus to cause.Intercostal neuralgia is mainly the regular pain of one or several intercostal, time have ictal aggravation, sometimes by respiratory movement, excited, cough, pain increases the weight of during sneeze.Si dol urg can be radiated to shoulder or the back of homonymy, is sometimes zonal distribution.During inspection, can find hyperesthesia and the corresponding rib edge tenderness of corresponding skin region, after intercostal nerves passes intervertebral foramina at back, breast sidewall, the place of passing, shirtfront be particularly remarkable.Some patient can find the corresponding sings and symptoms of various primary affections.
In addition, the intercostal neuralgia that taped blister examine disease toxicity neuritis causes refers to herpesvirus infringement skin and dorsal root ganglion, on the skin in its innervation district, produce vesicle and pimple in groups, and take vesicle as common, by intercostal nerves is arranged evenly, be banded, the while is with the neuralgia of nerve distribution area between one or several adjacent ribs.During morbidity, there are the prodromes such as low grade fever, tired, inappetence, then the local breast stomach wall deep pain that occurs hyperesthesia, burn feeling or varying degree.The treatment of Secondary cases intercostal neuralgia must be depending on the cause of disease.Constitutional intercostal neuralgia can be by neuralgic general treatement treatment, as the use of various analgesic, physical therapy etc.When invalid, can consider the sealing of intercostal nerves root.Skin lesion for herpes zoster can be protected desiccant to external, and as Pulvis Camphorae et Zinci Oxydi, Calamine Lotion or aldrich mixture, 5% Realgar tincture external also has anti-inflammatory analgetic effect; Suitably use vitamin B1, B12 and adrenocortical hormone often to have good effect.
When cough, sneeze, can make intercostal neuralgia pain increase the weight of.Si dol urg can be radiated to shoulder or the back of homonymy, is sometimes zonal distribution.During inspection, can find hyperesthesia and the corresponding rib edge tenderness of corresponding skin region, after intercostal nerves passes intervertebral foramina at back, breast sidewall, the place of passing, shirtfront be particularly remarkable.Some patient can find the corresponding sings and symptoms of various primary affections.For regular pain, rib relaxes. disappear. and swollen cream has the effect of reducing swelling and alleviating pain.In addition, the intercostal neuralgia that taped blister examine disease toxicity neuritis causes refers to herpesvirus infringement skin and dorsal root ganglion, on the skin in its innervation district, produce vesicle and pimple in groups, and take vesicle as common, by intercostal nerves is arranged evenly, be banded, the while is with the neuralgia of nerve distribution area between one or several adjacent ribs.During morbidity, there are the prodromes such as low grade fever, tired, inappetence, then the local breast stomach wall deep pain that occurs hyperesthesia, burn feeling or varying degree.
Intercostal neuralgia emergency case is because of the urgency of falling ill, and sharp ache during outbreak, all wishes alleviating pain at short notice when medical, but primary disease is temporarily without desirable specific treatment.Western medicine is generally taked to inject the agent that relieves the pain, or hormone therapy, and alleviating pain is rapid, but persistency poor stability is cured the symptoms, not the disease.Chinese medicinal formulae, with card plus-minus, does not have specific specific aim, and slowly, takes effect slow, and the painful time of sufferer is long, and sufferer is difficult for adhering to.
Summary of the invention
Technical problem to be solved by this invention is, for primary disease emergency case, because of the urgency of falling ill, sharp ache during outbreak, all wishes alleviating pain at short notice when medical, but primary disease is temporarily without desirable specific treatment.Western medicine is generally taked to inject the agent that relieves the pain, or hormone therapy, and alleviating pain is rapid, but persistency poor stability is cured the symptoms, not the disease.Chinese medicinal formulae, with card plus-minus, does not have specific specific aim, and slowly, takes effect slow, and the painful time of sufferer is long, and sufferer is difficult for adhering to; The common weak point of oral medicinal herb preparation and external preparation is, duration of efficacy is shorter, and specific aim is poor, and sufferer submissiveness is poor.
For solving these technical barriers, the invention provides a kind of Chinese medicine for external application for the treatment of intercostal neuralgia, in described external preparation, the parts by weight of various raw materials are: 10～20 parts of Semen Vaccariae, 10～20 parts of Olibanums, 10～20 parts of Myrrhas, 10～20 parts of Fructus Toosendans, 10～20 parts of Caulis Spatholobis, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Radix Paeoniae Rubra, 10～20 parts of Radix Saposhnikoviaes, 10～20 parts of Radix Notoginseng, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts, Flos Carthami, 10～20 parts of Rhizoma Corydalis, 10～20 parts of Herba Schizonepetae, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Clematidis, 10～20 parts of Eupolyphaga Seu Steleophagas, 10～20 parts of Pheretimas, 10～20 parts of Herba Artemisiae Anomalaes.
The Chinese medicine for external application of described treatment intercostal neuralgia, described in it, in external preparation, the parts by weight of various raw materials can be: 10～15 parts of Semen Vaccariae, 10～15 parts of Olibanums, 10～15 parts of Myrrhas, 10～15 parts of Fructus Toosendans, 10～15 parts of Caulis Spatholobis, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Radix Paeoniae Rubra, 10～15 parts of Radix Saposhnikoviaes, 10～15 parts of Radix Notoginseng, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts, Flos Carthami, 10～20 parts of Rhizoma Corydalis, 10～20 parts of Herba Schizonepetae, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Clematidis, 10～20 parts of Eupolyphaga Seu Steleophagas, 10～20 parts of Pheretimas, 10～20 parts of Herba Artemisiae Anomalaes.
The external preparation of described treatment intercostal neuralgia, described in it, in external preparation, the parts by weight of various raw materials can also be: 10～20 parts of Semen Vaccariae, 10～20 parts of Olibanums, 10～20 parts of Myrrhas, 10～20 parts of Fructus Toosendans, 10～20 parts of Caulis Spatholobis, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Radix Paeoniae Rubra, 10～20 parts of Radix Saposhnikoviaes, 10～20 parts of Radix Notoginseng, 10～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts, Flos Carthami, 10～15 parts of Rhizoma Corydalis, 10～15 parts of Herba Schizonepetae, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Radix Clematidis, 10～15 parts of Eupolyphaga Seu Steleophagas, 10～15 parts of Pheretimas, 10～15 parts of Herba Artemisiae Anomalaes.
For solving between above-mentioned technology, inscribe, the present invention also provides a kind of preparation method of Chinese medicine for external application for the treatment of intercostal neuralgia, and described in it, dosage form is unguentum, and its preparation method comprises:
A, Semen Vaccariae, Olibanum, Myrrha and Radix Notoginseng are distilled into crystallization by the way of distillation, pulverize standbyly, become component 1;
The medicinal residues of b, distillation and surplus stock are put into ethanol and are soaked, and heat is extracted 2 times, become paste, are component 2;
C, above-mentioned two kinds of extracts are merged, be condensed into powder and add vaseline and make unguentum.
In described step a, Semen Vaccariae, Olibanum, Myrrha and Radix Notoginseng can be distilled by the way of distillation, obtain crystal, be ground into fine powder and cross 100-120 mesh sieve, become component 1 standby.
In described step b, above-mentioned distilled medicinal residues can be mixed in the ethanol that other surplus stocks add 5-10 doubly to measure and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid,, removes supernatant after standing, and then 100-120 order filters, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000 again, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃; Above-mentioned two kinds of extracting solution are merged, and decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 ℃ 1.08; Being concentrated into relative density is 1.20, the extractum that temperature to 60 is ℃-70 ℃, and stand for standby use, becomes component 2.
In described step c, the extractum of component 1 and component 2 can be merged, then put into concentrating under reduced pressure tank, being evaporated to relative density is 1.20, then takes out, and mixes vaseline paste making agent.
For solving between above-mentioned technology, inscribe, the present invention provides a kind of preparation method of Chinese medicine for external application for the treatment of intercostal neuralgia again, and the dosage form of described preparation is unguentum, and preparation method can also be:
A. the crude drug of getting above-mentioned parts by weight is put into Oleum Sesami and is soaked except Semen Vaccariae, Olibanum, Myrrha and Radix Notoginseng; Heating is tempered;
B. Semen Vaccariae, Olibanum, Myrrha and the Radix Notoginseng way of distillation are distilled into crystallization;
C. the crystallization of sieving is put into the medicine oil of tempering, paste making agent
In described step a, can except Semen Vaccariae, Olibanum, Myrrha and Radix Notoginseng, add by the crude drug of described parts by weight in the Oleum Sesami of 5-10 times of weight portion and soak 7-10 days; By soaked Oleum Sesami crude drug heating extraction, big fire is boiled, and after Oleum Sesami boiling, firepower reduces, and endures to crude drug appearance and is dark brown, and inner coke yellow, pulls medicinal residues out, medicine oil is continued to temper, and constantly stir, and refining is to dripping into pearl; In described step b, Semen Vaccariae, Olibanum, Myrrha and the Radix Notoginseng way of distillation can be distilled into crystallization, and cross 200-300 mesh sieve after being ground into fine powder; In described step c, the crystallization fine powder sieving can be put into the medicine oil of tempering, paste making agent but after in impouring cold water, soak 5-10 days, change water every day once, releasing fire-toxin, adds appropriate vaseline paste making agent.
The Chinese medicine for external application of described treatment treatment intercostal neuralgia, described in it, external used medicine dosage form can be: unguentum, spray, powder, powder, ointment, gauze agent or emplastrum.
For intercostal neuralgia, at present not obviously medication targetedly of Western medicine, relieves the pain or the hormone treatment that relieves the pain mainly with injecting merely treatment in.And the traditional Chinese medical science is to have clear superiority in the effect of this type of disease for the treatment of, external preparation of the present invention, the present invention adopts the Chinese crude drug of different properties, through focus; Benefiting vital QI and blood, blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting.Improve local blood capillary obstacle on the one hand, blood circulation promoting, comes off slough as early as possible, reaches tissue repair; Prevention infection simultaneously, enhancing human body immunity function; External application can improve circulation effectively, increases the groundwater increment of local organization, and blood circulation promoting reaches the object for the treatment of.Drug matching of the present invention is reasonable, there is antiinflammatory action by force and lastingly, can suppress infectious and non-infectious inflammation, alleviate the permeability of hyperemia, reduction blood capillary, inflammation-inhibiting cell etc. reacts, and suppresses cytophagous function, stablizes lysosome membrane, stop complement to participate in inflammatory reaction, the reparation of tissue injury after inflammation-inhibiting.Its toxic and side effects is little, easy to use, and healing time is short, after curing, is difficult for recurrence.Can create good social value and economic interests.
The specific embodiment
The traditional Chinese medical science is classified intercostal neuralgia as the category of " costa sternales rheumatism involving the bone ".Think the large factor of being formed with of this disease inside and outside two.Interior because deficient qi and blood is sought and defended incoordination between the exterior and the interior, imbalance of YIN and YANG, muscles and bones mistake are supported; Exopathogenic factor is sternocostal part sprain and contusion once in a while, wind-cold damp pathogen invasion, the stagnant muscles and bones of the stasis of blood, blocks venation, cause QI-blood circulation obstructed due to.Qi depression to blood stasis, wind heat invasion meridians, scorchingly hot friendship is vehement, and QI and blood heap soil or fertilizer over and around the roots is held back obstructed, stagnation of QI and blood may bring about pain.Intercostal neuralgia is acute onset, can repeatedly show effect, time have an ictal aggravation.
Primary disease belongs to motherland's medical science " hypochondriac pain " category.< < Ling Shu Miraculous Pivot or Divine Axis passages through which vital energy circulates piece of writing > > says: " arteries and veins of liver, the sufficient the moon of fainting ... belong to liver, network gallbladder ... cloth side of body rib." " arteries and veins of gallbladder, the few sun of foot, network liver, belongs to gallbladder, follows in the side of body ... its straight person, and axil from supraclavicular fossa, follows the breast side of body out of season." again < < five pathogenic factors piece of writing > > say: " evil in liver, pain in two sides of body ... " < < pathogen hides mansion sick shape piece of writing > > and says: " falling down to some extent, in stagnant blood stays, if rage to some extent, on gas and not, amass under the side of body impairing the liver." the sweet core case of < < fourth gastral cavity hypochondriac pain) the right case of multitude says: " side of body is the dividing line of liver, irritability enters network, hypochondriac pain is to the left ... " all pointed out that breast side of body position is liver, part that gallbladder distributes, therefore the functional disorder of the pain of breast side of body portion and liver and gall two warps has certain relation.Illustrate simultaneously falling down (draw together injury from falling down stagnant blood amass in the side of body under, rage anger amass in the side of body under be two kinds of reasons that can cause hypochondriac pain.
< < faces disease guide case-hypochondriac pain door > > Wang case and says: " pain is at side of body rib, and migration is indefinite ...." pointed out that chest and hypochondrium both sides all can occur, also conform to being seen intercostal neuralgia one disease of modern times.The intercostal neuralgia that clinical findings is simple, its cause of disease mainly not outer depression of liver-QI, expectorant blood is at a stop, as the contrary gas that bears a heavy burden, or due to the incoordination overexerting between caused costicartilages such as (strain stimulate tissue metabolism after intercostal nerves, mechanical stimulation, work to produce acid product as lactic acid etc.) and breastbone.Also there is no aforementioned medical history, but because be with the passing of time overworked for a very long period costicartilage part, be occasionally subject to light pressure or cough, thereby cause this place's trauma and this disease occurs suddenly.
In the treatment aspect the traditional Chinese medical science, the symptom of the unguentum of relax rib, detumescence to intercostal neuralgia, can well treat.Intercostal neuralgia claims again intercostal nerves inflammation, and only actually is a kind of title of symptom, two kinds of point constitutional and Secondary cases, and common with Secondary cases intercostal neuralgia clinically, constitutional intercostal neuralgia is more rare.
Secondary cases intercostal neuralgia is to be caused by adjacent organs and lesion tissue, as thoracic organs pathological changes (pleuritis, chronic pneumonia, aortic aneurysm etc.), spinal column and the damage of rib, senile vertebra osteoarthritis, thoracic vertebra section deformity of spine, thoracic vertebra section tumor of spinal cord, normal pressuring neural root and occur symptom,, also can there is intercostal neuralgia in the intercostal nerves inflammation that varicella zoster virus causes.The intercostal neuralgia that herpes zoster causes is because determining fixing pressure pain point difficulty in part, to having erythra and local skin the infected not to use the method.For the treatment of intercostal neuralgia, the traditional Chinese medical science is used the treatments such as medicine for external use unguentum, Acupuncture Chinese medicine, acupuncture point pricking and cupping, acusector to obtain satisfactory effect.But from convenient and swift aspect, doctor trained in Western medicine may be more suitable for emergency case.But can not effect a permanent cure.
Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly and is applied to the latus rectum of invigorating blood circulation, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury.< < book on Chinese herbal medicine converges says > >: Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, tune blood also.Main tire produces all kinds of diseases and ailments because blood is for suffering from, or the tired bruise of blood, and coma in silence; Or lochia is robbed the heart, umbilicus angina abdominis; Or drop slurry is difficult raw; Or afterbirth do not fall, dead fetus in the uterus, is all just before giving birth all cards, and non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy enters blood chamber, delirium is gone mad; Or blood is vexed interior swollen, sudden syncope with rigidity is as extremely, be all puerperal all cards, non-Flos Carthami can not be determined.All as obstructed in amenorrhea and cold and heat are handed over and are done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood are long-pending, or skin infection sufferings and swollen burst uneasyly, be cards of disharmony between QI and blood all, non-Flos Carthami can not be adjusted, Flos Carthami promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, there are the thrombosis of inhibition, antiinflammatory, analgesic effect, there is the vasoconstrictive effect of eliminating epinephrine, norepinephrine, have " tonneau passages through which vital energy circulates " effect.
Rhizoma Chuanxiong is pungent, temperature.Enter liver, gallbladder meridian.Activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled headache revolve dizzy, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.< < herbal classic > > carries it: main apoplexy enters brain headache, arthralgia due to cold, and clonic spasm of the muscle emergency, gold wound, married woman's blood closes loss of fecundity.< < does not record > > and carries it: " except cold moving in brain, on face, urticaria goes, order lacrimation, profuse nasal discharge and spittle; before we notice it as liquor-saturated, all cold gas, the hard pain of trusted subordinate, attacked by pestiferous factors; soldier is anxious to swell and ache, side of body wind pain, warming middle-JIAO endogenous cold." be the good medicine of regulating qi to disperse stagnation
Radix Salviae Miltiorrhizae hardship, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, the tumbling down pain of injury, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.. < < detailed outline > > carries: Radix Salviae Miltiorrhizae, press the sensible opinion of < < married woman > > cloud, SIWU TANG is controlled gynecopathy, antenatal puerperal not, how many through water, all can be general, only taste Radix Salviae Miltiorrhizae is loose, cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, the stillborn fetus that falls, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has the effect of invigorating blood circulation trace, and can promote liver blood circulation, is beneficial to liver cell regeneration.
Caulis Spatholobi property hardship, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, < < A Supplement to the Compendium of Materia Medica > > carries it and can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea.External is gynecological's good medicine of activating blood circulation to dissipate blood stasis.
Semen Vaccariae another name Wang Buliu, Vaccaria segetalis.For the dry seed of pinkwort Vaccaria segetalis Vaccariasegetalis (neck) Garcker, there is promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, expedites the emergence of the function of stimulating milk secretion.Cure mainly menoxenia, agalactosis, difficult labour, the diseases such as carbuncle furunculosis.< < herbal classic > >: main incised wound, hemostasis, by pain, goes out thorn, except migratory arthralgia endogenous cold.2. < < does not record > >: stop vexed epistaxis, carbuncle malignant boil, flaccidity breast, married woman's difficult labour.
Radix Notoginseng sweet in the mouth; Micro-hardship; Warm in nature.Return Liver Channel; Stomach warp; Heart channel; Lung meridian; Large intestine channel.Radix Notoginseng (Panaxnotoginseng (BurK.) F.H.Chen) is araliaceae ginseng plant, it is Chinese distinctive rare Chinese medicine, one of Ye Shi China medicinal and edible plant the earliest, Radix Notoginseng is just acknowledged as since ancient times has significant blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain effect, has the good reputation of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ", " southern part of the country SHENCAO ".Because branch divides three, be seven, therefore be called " Radix Notoginseng ", have another name called Radix Notoginseng, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) etc., ancient times also claims clear ginseng, Herba Wedeliae Wallichii, Panax pseudoginseng, Typhonium flagelliforme (Lodd.) Blume, mountain paint, Radix Notoginseng etc.Because being everlasting, excavate in two seasons of winter in spring, be divided into again " spring seven " and " winter seven ".Because Radix Notoginseng is all panax species, and its effective active matter higher than with more than Radix Ginseng, therefore by modern Chinese medicine medicine scholar, be called " king in ginseng " again.Radix Notoginseng " promoting tissue regeneration by removing blood stasis ", modern study confirms that Radix Notoginseng has blood tonification effect.Through 60C0-radiation gamma mice, inject 6 days continuously in PNS abdominal cavity, and the propagation of pluripotential hemopoietic stem cell is had to obvious facilitation, and in spleen tuberosity, grain, red two is that cell mitogen is active, and spleen weight increases.The murine interleukin that cyclophosphamide is caused reduces, and PNS also has promotion restitution.In rat acute hemorrhagic anemia, Radix Notoginseng injection can significantly promote the recovery of erythrocyte, reticulocyte, hemoglobin.Radix Notoginseng is the common medicine for the treatment of traumatic injury, has definite analgesic activity.The multiple pain models such as mouse writhing method, hot plate method and rat light radiation tail-flick method are had to analgesic activity.Analgesic effective component is Panaxadiol saponin.
Olibanum acrid, bitter, warm.Enter the heart, liver, spleen channel.Regulating qi and activating blood, analgesic therapy, chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.< < does not record > >: treat edema due to wind pathogen poison swollen, remove bad odor.Treat the urticaria poison of itching.< < Bencao Shiyi > >: treat deaf, apoplexy locked mouth, married woman's vim and vigour, can send out wine, manage air-cooledly, stop large intestine and let out Bleach, treat all skin ulcers and make internal diabetes.
Myrrha cures mainly breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.There are the effects such as promoting blood circulation and stopping pain, detumescence and promoting granulation.Raw property or lymphatic temperament disease, as raw property arthralgia, sciatica, oral cavity pain, has sore throat, cold cough, moist abundant expectoration, bronchiectasis, eczema abscess, menoxenia, dysuria.1. < < note doctor allusion quotation > >: " softening the hard mass is except tumor for hair growing, the speckle dispelling trace that disappears, and except tinea more wound, teeth consolidating be good for gum, detoxifies etc.Control alopecia capillary, black speck scar, verruca plana, various eczema, gingiva erosion, poisonous insect stings wound etc." 2. < < visit according to medicine book > >: " anticorrosion deodorization etc.Control bromhidrosis, pudendum stink etc.”
Herba Artemisiae Anomalae is the herb of feverfew artemisia anomalas, and it has the hemostasis of curing the wound, and removing blood stasis stimulates the menstrual flow, promoting digestion and removing stagnation, the effect of the appetizing of being amusing.It can be used for acute icterohepatitis, toothache, chronic tracheitis, stomatitis, pharyngolaryngitis, tonsillitis, nephritis, malaria; Eye conjunctivitis is controlled in external, otitis media, skin infection, eczema, traumatic hemorrhage.
Radix Paeoniae Rubra, clots absorbing, pain relieving, removing heat from blood, detumescence.Cure mainly: control that the stagnant amenorrhea of the stasis of blood, hernia abdominal mass gather, stomachache, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle, injury from falling down.The Radix Paeoniae Rubra point excess-heat that can purify the blood, dissipating blood stasis blood is detained.This product function is close with Cortex Moutan, therefore normal and Cortex Moutan mutual reinforcement between are use.But the effect of Cortex Moutan clearing away heat and cooling blood is better, point excess-heat that can purify the blood, can control again fever due to yin deficiency; And Radix Paeoniae Rubra can only be used for blood system excess-heat, with promoting blood circulation to remove blood stasis, be good at.< < herbal classic > >: main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating.
Its root of Radix Clematidis and stem be used as medicine there is rheumatism, effect that the meridian dredging, the bone that disappears are choked.In modern clinic practice, its new purposes is constantly found, as treatment cholelithiasis, calcanean spur, talalgia, the esophageal carcinoma etc.But in medication, it is noted that the careful clothes of deficiency of qi and blood and anemia of pregnant woman.Expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the loose hypochondriac lump.Cure mainly gout insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, knee joint cold type of pain, the contracture of muscle arteries and veins, joint stuffiness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.< < Kaibao Bencao > >: main all wind, Xuan Tongwu hides, and goes abdomen interior cold stagnant, and septum cordis expectorant water is long-pending for a long time, lump in the abdomen Xuan tinea air parcel, bladder place pus aversion to water, the cold pain of waist knee joint and treatment injured.
Radix Angelicae Dahuricae meridian distribution of property and flavor: pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping.< < Japan hanako materia medica > >: control conjunctival congestion bulbar conjunctiva polyp, and tire patching leaks landing, broken stagnated blood, mend fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, evacuation of pus, desolation, scabies, pain relieving granulation promoting, goes face Shao-defect scar.
Rhizoma Corydalis cures mainly all pains of trusted subordinate's waist knee joint; Menoxenia; Lump in the abdomen; Metrorrhagia; Puerperal blood faints; Lochiorrhea; Traumatic injury.There are analgesia, calmness, syngignoscism.Invigorate blood circulation; Dissipating blood stasis; Regulate the flow of vital energy; Pain relieving.The all pains of main trusted subordinate's waist knee joint; Menoxenia; Lump in the abdomen; Metrorrhagia; Puerperal blood faints; Lochiorrhea; Traumatic injury.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.Analgesic activity: Rhizoma Corydalis powder has analgesic activity, its pain relieving is tired and is about 1/100 of opium; Rhizoma Corydalis total alkaloids, Corydaline, second element, ugly element, the last of the ten Heavenly stems, element all had analgesic activity, stronger with second element. and various dosage forms are strong with alcohol extractum processed and powder effect.< < Kaibao Bencao > >: main removing blood stasis, puerperal all diseases, because of the blood person of doing.Married woman's menoxenia, lumps in abdomen, and metrorrhagia is drenched and revealed, and puerperal, blood was transported, and sudden and violent blood rushes to, and because damaging hematochezia, or wine rubs and boils clothes.
Herba Schizonepetae taste is flat, and warm in nature, nontoxic, faint scent is dense.Herba Schizonepetae is diaphoresis, and antipyretic is one of conventional medical herbs of China.Energy town expectorant, timid wind, removing heat from blood.Control influenza, the diaphoresis of headache cold and heat, vomiting.Dispel the wind; Induce sweat; Rash; Hemostasis.Main cold, fever; Headache; Eye itching; Cough; Laryngopharynx swelling and pain; Measles; Carbuncle; Skin ulcer scabies; Epistaxis; Spit blood; Have blood in stool; Metrorrhagia; Puerperal blood faints.For flu, headache, measles, rubella, skin infection from the beginning of.< < detailed outline > >: loose wind heat, refresh oneself, throat, the skin ulcer that disappears is swollen.Control stiffness of the nape, black flower in order, and raw skin ulcer, cloudy ruined, spit blood, epistaxis, hematochezia, dysentery, metrorrhagia, anal fistula.
Radix Saposhnikoviae nature and flavor: acrid in the mouth; Sweet; Slightly warm in nature.Return urinary bladder channel; Lung meridian; Spleen channel; Liver Channel.Expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.Cure mainly: affection of exogenous wind-cold; Headache general pain; Rheumatic arthralgia; Joint is ached; Stomachache is had loose bowels; Discharging fresh blood stool; Tetanus; Rubella pruritus; Skin infection from the beginning of.Extracorporeal bacteria inhibitor test: adopt flat band method to carry out In Vitro Bacteriostasis experiment, result Radix Saposhnikoviae has bacteriostasis to staphylococcus aureus, beta hemolytic streptococcus, Diplococcus pneumoniae and two kinds of mycetes (Penicllium chrysogenum, aspergillus versicolor) etc., and to hemophilus influenza, Bacillus typhi, Fu Shi and dysentery bacterium without bacteriostasis.< < herbal classic > >: main large dizziness due to wind pain, aversion to wind, ailment said due to cold or exposure, order blindness, is in fashion the whole body, arthralgia numbness, stuffy sensation with restlessness.
Eupolyphaga Seu Steleophaga: Eupolyphaga Seu Steleophaga is a herb is the female worm dry body of Corydiidae insecticide eupolyphoge sinensis (Eupolyphaga sinensis Walker) or Ji eupolyphoge sinensis (Steleophaga plancyi, i.e. Boleny).There is the effect of removing blood stasis, reunion of fractured tendons and bones, and have thrombolytic mechanism.It is cold in nature, taste becomes, poisonous, can enter conscience spleen three warps, there is removing blood stasis, removing mass, dredging collateral, reason wound and reunion of bone, reducing swelling and alleviating pain, the stimulating milk secretion effect such as stimulate the menstrual flow, be treating blood disorders traumatology key medicine, be applicable to the diseases such as cancer abdominal mass is gathered, amenorrhea due to stagnation of blood, postnatal blood stasis stomachache, traumatic injury, swollen and rigid tongue, congenital deformity of the tongue.Traumatic injury, injury of tendon and muscle fracture, pain caused by ecchymoma.This product Cheng Han enters blood, and master enters Liver Channel, and property is apt to away alter, the pain relieving of energy promoting blood circulation and detumescence, and reunion of fractured tendons and bones is cured the wound, and is traumatology common medicine, is especially used for the injury of tendon and muscle of fracturing, swelling and pain due to blood stasis.Can alonely grind into powder and dress, or grind yellow wine into powder and take after mixing it with water; Clinical normal and Pyritum, Rhizoma Drynariae, Olibanum are equal to use.
Pheretima: < < Compendium of Materia Medica > > is referred to as to have dredge the meridian passage, blood circulation promoting and blood stasis dispelling, the effect of prophylactic treatment cardiovascular and cerebrovascular disease.Pheretima taste cold in nature becomes.Function: heat clearing away, suppressing the hyperactive liver, Zhichuan, logical Lip river.Cure mainly height fanatical dry, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, hemiplegia etc.Pheretima provides gets liquid and has the good effect that cloperastine is breathed heavily of determining.
The preparation method of externally used paste of the present invention:
According to described umber, Semen Vaccariae 1000g, Olibanum 1000g, Myrrha 1000g and Radix Notoginseng 1000g are distilled into crystallization, standby, get the medicinal residues mixing surplus stock Fructus Toosendan 1000g after distillation, Caulis Spatholobi 1000g, Rhizoma Chuanxiong 1000g, Radix Paeoniae Rubra 1000g, Radix Saposhnikoviae 1000g, Radix Angelicae Dahuricae 1000g, Flos Carthami 1000g, Rhizoma Corydalis 1000g, Herba Schizonepetae 1000g, Radix Salviae Miltiorrhizae 1000g, Radix Clematidis 1000g, Eupolyphaga Seu Steleophaga 1000g, Pheretima 1000g, Herba Artemisiae Anomalae 1000g, the 60-90% soak with ethanol 1-2 hour that adds 5-10 doubly to measure, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000 again, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated, 30 minutes～45 minutes, concentrated solution is settled into extractum shape, mass continues heating and is concentrated into extractum shape, stand for standby use, become component 2, the component of the component of distillation extraction 1 and ethanol extraction 2 is mixed, and paste making agent, adds appropriate vaseline paste making agent.
The ointment that also can obtain with said method soaks gauze, makes gauze agent, every night or the free time encase sufferer place, slowly massage half an hour-1 hour.
The preparation method of external patch unguentum of the present invention:
According to described umber just Semen Vaccariae 1200g, Olibanum 1200g, Myrrha 1100g and Radix Notoginseng 1200g be distilled into crystallization, standby, get the medicinal residues mixing surplus stock Fructus Toosendan 1100g after distillation, Caulis Spatholobi 1200g, Rhizoma Chuanxiong 1300g, Radix Paeoniae Rubra 1200g, Radix Saposhnikoviae 1300g, Radix Angelicae Dahuricae 1200g, Flos Carthami 1300g, Rhizoma Corydalis 1200g, Herba Schizonepetae 1200g, Radix Salviae Miltiorrhizae 1300g, Radix Clematidis 1200g, Eupolyphaga Seu Steleophaga 1300g, Pheretima 1300g, Herba Artemisiae Anomalae 1200g, in the ethanol that adds 5-10 doubly to measure, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000 again, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated into paste, stand for standby use, become component 1, the medicinal residues of the component raw medicinal material that above-mentioned ethanol extraction is crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing, above-mentioned two kinds of extracting solution are merged, and decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 ℃ 1.08, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 ℃, and being concentrated into relative density is 1.20, and the extractum that temperature to 60 is ℃-70 ℃, becomes component 2, the paste of component 1 and component 2 after merging is put into concentrating under reduced pressure tank, mix the crystalline powder of pulverizing, being evaporated to relative density is 1.20, the paste that temperature to 60 is ℃-70 ℃, be pressed into nonwoven gauze, make emplastrum.
Externally used paste preparation method of the present invention can also be:
By the crude drug raw material Fructus Toosendan 1200g of described parts by weight, Caulis Spatholobi 1300g, Rhizoma Chuanxiong 1300g, Radix Paeoniae Rubra 1200g, Radix Saposhnikoviae 1300g, Radix Angelicae Dahuricae 1200g, Flos Carthami 1300g, Rhizoma Corydalis 1200g, Herba Schizonepetae 1200g, Radix Salviae Miltiorrhizae 1300g, Radix Clematidis 1200g, Eupolyphaga Seu Steleophaga 1300g, Pheretima 1300g, Herba Artemisiae Anomalae 1300g, adds in the Oleum Sesami of 5-10 times of weight portion and soaks 7-10 days; By soaked Oleum Sesami crude drug heating extraction, big fire is boiled, and after Oleum Sesami boiling, firepower reduces, and endures to crude drug appearance and is dark brown, and inner coke yellow, pulls medicinal residues out, medicine oil is continued to temper, and constantly stir, and refining is to dripping into pearl; In described step b, Semen Vaccariae 1200g, Olibanum 1100g, Myrrha 1300g and the Radix Notoginseng 1200g way of distillation are distilled into crystallization, and cross 200-300 mesh sieve after being ground into fine powder; In described step c, the crystallization fine powder sieving is put into the medicine oil of tempering, paste making agent but after in impouring cold water, soak 5-10 days, change water every day once, releasing fire-toxin, adds appropriate vaseline paste making agent.
Toxicity test:
Acute toxicity testing data
1, experimental technique
Guinea pig back spinal column both sides are evenly coated depilatory, make approximately 40 square centimeters of unhairing scopes.Clean depilatory returns cage to observe 24 hours, every group of Cavia porcellus is coated with respectively Chinese medicine preparation external spraying agent 0.2,0.4 of the present invention and 0.8ml, respectively containing crude drug 92mg, 184mg and 368mg), another group is coated with the every twice-daily of solvent 0.8ml, and continuous one week, after experiment finishes, Cavia porcellus is put to death, the heart, liver, kidney and depilation skin do pathological examination.
2, result
Above-mentioned three groups of medication Cavia porcellus trunks depilation district, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group Cavia porcellus chroma of hair, ingest, the matched group no significant difference such as extremity activity, histopathologic examination, the administration group heart, liver, kidney and depilation skin with contrast more also no significant difference of word.
Results suggest, Chinese medicine for external application of the present invention, without local irritant effect, also has no general toxicity performance.Show that Chinese medicine for external application of the present invention is used safety.
Long term toxicity test data
1, experimental technique
By random Cavia porcellus part, become 4 groups, 15 every group.In guinea pig back spinal column both sides, depilatory is evenly coated, made approximately 40 square centimeters of its depilation scopes.Clean depilatory, observe every group of Cavia porcellus after 24 hours and be coated with respectively external spraying agent 0.2,0.4 of the present invention and 0.8ml, respectively containing crude drug 92,184 and 368mg), another group is coated with the every twice-daily of solvent 0.8ml, continuous 30 days, observe the ordinary circumstance of Cavia porcellus, experiment finishes rear execution animal and carries out hematology, blood biochemical and pathological examination.
2, result
Above-mentioned three groups of medication Cavia porcellus trunk unhairing districts, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group and control animals chroma of hair, ingest, the matched group no significant difference such as extremity activity, blood biochemistry checking, medication group and matched group are all in normal range.Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious pathological changes.Prompting, Chinese medicine preparation long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ.Result of the test shows: Chinese medicine preparation experiment safety of the present invention.
External preparation antibacterial tests of the present invention
Experiment material
1, animal subject: Kunming mouse, 18-22g, male and female half and half; Instar chicken embryo on the 9th.2, antibacterial and virus: bacterial isolates is clinical separation strain, totally 97 strains; Flu virus FMl strain.3, plate: MH culture medium; Streptococcus pneumoniae adopts blood meida, in MH culture medium, adds 5% defiber Sanguis caprae seu ovis to make; Hemophilus influenza adopts chocolate culture-medium.
2, In vitro Bactericidal Experiments
1, the mensuration of external minimum inhibitory concentration (MIC)
(1) experimental technique: be subject to reagent (external preparation of the present invention) to extract extractum sterile saline and be diluted to following Concentraton gradient, i.e. 1600,800,400,200,100,50,25,12.5,6.25,3.13 (mg/m1), draw respectively 1.5ml to aseptic plate, add again the sterilizing MH culture medium in 55 ℃ of water-baths of 13.5ml constant temperature, mix rear cooling standby.The ultimate density of the dull and stereotyped Chinese medicine of each medicine is 160,80,40,20,10,5,2.5,1.25,0.625,0.313 (mg/m1).Establish blank group simultaneously.The test organisms of cultivating 8-12h is diluted to desired concn (being generally 107CFU/m1) with sterile saline, adopts multiple spot inoculation instrument to be connected to the medicine flat board of variable concentrations, inoculum concentration is about 104～105CFU.Test organisms is in 24 hours observed results of 37 ℃ of constant temperature culture, and records MIC value.
(2) experimental result
In vitro Bactericidal Experiments result shows (following table), Grain-positive and the Grain-negative clinical bacteria of medicine to upper respiratory tract infection is all inhibited, wherein the MIC50 of staphylococcus aureus, staphylococcus epidermidis, streptococcus pneumoniae, bloodthirsty hemophilus influenza, Klebsiella Pneumoniae, escherichia coli and bacillus pyocyaneus is respectively to 10,20,20,2.5,40,20 and 10mg/ml, MIC90 is respectively 80,40,80,20,160,40 and 160mg/ml.
Table 1 vitro antibacterial activity
Pharmacological experiment:
Microcirculation experimental technique:
1. materials and methods: get 50 mices, be divided at random 5 groups, 10 every group (male and female half and half), the every Mus auris dextra of matched group be coated with normal saline a little; The every Mus auris dextra of positive controls is trained first HUOXUE ZHITONG GAO, and test component is dosage group 600mg/kg/h in unguentum low dose group 400mg/kg/h of the present invention, unguentum of the present invention, unguentum high dose 800mg/kg/h of the present invention.15min pneumoretroperitoneum is injected 0.1% pentobarbital sodium 0.1ml/10g anesthetized animal, tail vein injection 0.1% epinephrine 0.1mL/10g subsequently, and (μ is m) and 0.2mm2 blood capillary net number .t check place to observe immediately mouse right ear fine motion vein bore
Reason experimental data.
2 results and discussion
2.1. on microcirculatory impact
Compared with matched group, tested group 1 has showed increased (P<0.01) to the open number of mice blood capillary; Tested group 2 venule bore and the open number of blood capillary are had to remarkable increase (P<0.01); Tested group 3 the open number of mice fine motion, vein bore and blood capillary is all had to increase (P<0.01); Illustrate and be subject to reagent can improve microcirculation, have function of promoting blood circulation to disperse blood clots (table 1).
Table 1, the impact of the present invention on the open number of mice fine motion, vein bore and blood capillary
3, the impact of the present invention on the healing of rat refractory wound surface.
3.1 materials and methods
3.1.1 animal: 40 of clean level SD rats, male, weight 200-220g, average (220.32 ± 10.10) g (being provided by biology department of Shandong University breeding center).
3.1.2 medicine: vaseline, necrosis removing and granulation promoting plaster, externally used paste of the present invention.
3.1.3 reagent and instrument: ketaject injection (every 011g/2mL, Hengrui Medicine Co., Ltd., Jiangsu Prov. produces, lot number: KH051001); Hydrocortisone sodium succinate (every 50mg/2mL, Tianjin Biochemical Pharmaceutical Factory produces, lot number: 20010419,20060104); Benzylpenicillin sodium for injection (800,000 U/ prop up, and Huabei Pharmaceutic Co., Ltd produces, lot number: Y0511222).Electrocardiograph paper (specification 50mm × 30m, Shanghai three or five company limiteies of paper plant produce).
3.1.4 modeling method: full thickness dermal method is made animal body surface Ulcer Models.Rat is divided into 5 groups at random: general wound surface group, model control group, vaseline group, necrosis removing and granulation promoting plaster group, unguentum of the present invention, 8 every group.After rats by intraperitoneal injection ketalar (100mg/kg body weight) anesthesia, molding bay (lumbar vertebra center is on the upper side) is shaved hair, with diameter 2cm plastic bottle closure at molding bay labelling modeling area, benzalkonium bromide tincture cotton balls skin degerming, along mark line, cut off subcutaneous tissue to muscular fasciae, hemostasis, antiseptic gauze dressing covers wound, forms the open wound model of rat full thickness dermal (general wound surface).Except general wound surface group, 4 groups of Shes intramuscular injection hydrocortisone sodium succinate (8mg/100g body weight) at once after modeling, makes refractory wound surface model, injects continuously 5 days.Operation rose the same day, every group of equal intramuscular injection penicillin sodium salt (4000U/ is only), for three days on end, in case infect.
1.5 medication
Each group starts to change dressings in modeling next day, and every day 1 time, before changing dressings, all with 1/5000 nitrofural clean wound, general wound surface group and model control group all cover with normal saline gauze; All the other each groups spread on wound surface with vaseline, white jade cream or gauze respectively, and external sterile gauze covers, and medical proof fabric is fixed, and changes dressings until all wound surface all heal.
1.6 observation index
1.6.1 Wound healing rate: after modeling the 5th, 7,10 days, use hyaline membrane flap coverage, mark stroke film, then hyaline membrane is covered and on electrocardiograph paper, calculates wound surface area.By following formula, calculate Wound healing rate: healing rate=(original wound surface area-wound surface area does not heal)/original wound surface area × 100%.
1.6.2 wound healing time: record plays the complete epithelization required time of wound surface from topical agent.
1.7 statistical method
Adopt SPSS11.0 software to carry out data analysis.Continuous data represents by mean ± standard deviation, carries out relatively group difference of multiple sample one factor analysis of variance.
2 results
2.1 impacts on Wound healing rate
The 5th day, the 7th day, the 10th day model control group Wound healing rate, all lower than general wound surface group (P<0.05), shows modeling success.The 5th day, each intervention group Wound healing rate was compared no significant difference (P>0.05) with model control group; The 7th day, vaseline group, necrosis removing and granulation promoting plaster group healing rate were all higher than model control group (P<0.05); The 10th day, unguentum group healing rate of the present invention was apparently higher than vaseline group, necrosis removing and granulation promoting plaster group (P<0.01).In Table 1.
The comparison of the each group of table 1 different time points Wound healing rate (% ,-x ± s)
With the comparison of general wound surface group, * P<0.05; With model control group comparison, △ P<0.05, △ △ P<0.01.
Clinical data:
Intercostal neuralgia is acute onset, can repeatedly show effect, time have an ictal aggravation.Emergency case is because of the urgency of falling ill, and sharp ache during outbreak, all wishes alleviating pain at short notice when medical, but primary disease is temporarily without desirable specific treatment.Chinese medicine thinks, loses intercostal neuralgia and be blood stasis with the passing of time after herpes zoster, blocks in Liver Channel, causes qi depression to blood stasis and causes the pain over the hypochondriac region.My institute takes to lose intercostal neuralgia 30 examples after Chinese medicine for outer use treatment herpes zoster for 2009～2012 years, satisfactory effect, and existing report is as follows.
Physical data: this organizes 30 examples, male 18 examples, female's 12 examples; Minimum 19 years old of age, maximum 65 years old; The course of disease is the shortest 1 month, the longest 6 months.Therapeutic Method, ingredients: Semen Vaccariae 15g, Olibanum 15g, Myrrha 16g, Fructus Toosendan 14g, Caulis Spatholobi 13g, Rhizoma Chuanxiong 16g, Radix Paeoniae Rubra 14g, Radix Saposhnikoviae 15g, Radix Notoginseng 16g, Radix Angelicae Dahuricae 15g, Flos Carthami 16g, Rhizoma Corydalis 16g, Herba Schizonepetae 15g, Radix Salviae Miltiorrhizae 16g, Radix Clematidis 15g, Eupolyphaga Seu Steleophaga 16g, Pheretima 16g, Herba Artemisiae Anomalae 15g.Make unguentum, smear every day, massage affected part half an hour.
Therapeutic outcome:
Criterion of therapeutical effect: cure: conscious pain symptom disappears; Effective: conscious pain symptom obviously alleviates; Invalid: before and after treatment, conscious pain symptom is without alleviating.
Result: this organizes 30 examples, cures 24 examples, effective 4 examples, invalid 2 examples.Total effective rate 93.33%.5～12 days courses for the treatment of.
Discuss: herpes zoster is due to varicella zoster virus infection.Because this virus has neurotropism, in the neuron of after the spinal nerves root of can hiding for a long time after infection.Some patients were erythra can be left over intractable intercostal neuralgia after disappearing, and continues the several months long, and especially old people is comparatively obvious, impact sleep and orthobiosis.Regulating QI to relieve pain of the present invention; Blood circulation promoting regulates qi; Soothing the liver circulation of qi promoting, draw all medicines enter through.All medicines share, can promoting flow of QI and blood, dredge the meridian passage.In therapeutic process, be aided with psychological counseling, curative effect is better.
Specific embodiment 1: Wang, man, 26 years old, during the work of readme earlier month, firmly excessive, unable to do what one wishes, injure venation, QI and blood is not smooth, and congestion is stagnated.Especially left rib is as pain as pinprick, and the severe pain of pressing is moving more so, change one's position can not, lie awake all night.Be diagnosed as intercostal neuralgia.Doctor trained in Western medicine control of medication is lived pain and is gone back to go to work.Soon recurrence, treats to the court.Main suit: two ribs still feel a dull pain, strengthens when nervous or tired.Diagnosis intercostal neuralgia, belongs to liver qi stagnation type.Side uses: Semen Vaccariae 15g, Olibanum 15g, Myrrha 16g, Fructus Toosendan 14g, Caulis Spatholobi 13g, Rhizoma Chuanxiong 16g, Radix Paeoniae Rubra 14g, Radix Saposhnikoviae 15g, Radix Notoginseng 16g, Radix Angelicae Dahuricae 15g, Flos Carthami 16g, Rhizoma Corydalis 16g, Herba Schizonepetae 15g, Radix Salviae Miltiorrhizae 16g, Radix Clematidis 15g, Eupolyphaga Seu Steleophaga 16g, Pheretima 16g, Herba Artemisiae Anomalae 15g.Make unguentum, smear every day, massage affected part half an hour.After medication 3 days, sensory symptoms alleviates, and adheres to recovery from illness after month.
Specific embodiment 2: the Qin, female, 36 years old, teacher, bilateral intercostal pain 2 months, once arrived examination in hospital, got rid of liver and gall solid lesion.Be diagnosed as intercostal neuralgia.Doctor trained in Western medicine control of medication is lived pain and is gone back to go to work.Just recurrence, does not treat to the court.Main suit: two ribs still feel a dull pain, strengthens when nervous or tired.Doublely see menoxenia, irritability; Eyes are astringent, and red tongue tongue is few, the slightly outstanding number of thready pulse.Diagnosis intercostal neuralgia, belongs to liver qi stagnation type.Side uses: Semen Vaccariae 15g, Olibanum 17g, Myrrha 16g, Fructus Toosendan 14g, Caulis Spatholobi 13g, Rhizoma Chuanxiong 16g, Radix Paeoniae Rubra 14g, Radix Saposhnikoviae 15g, Radix Notoginseng 16g, Radix Angelicae Dahuricae 15g, Flos Carthami 16g, Rhizoma Corydalis 16g, Herba Schizonepetae 15g, Radix Salviae Miltiorrhizae 16g, Radix Clematidis 15g, Eupolyphaga Seu Steleophaga 15g, Pheretima 16g, Herba Artemisiae Anomalae 17g.Make unguentum, smear every day, massage affected part half an hour.After medication 3 days, sensory symptoms alleviates, and adheres to recovery from illness after month.After medication 35 days, sensory symptoms alleviates, and adheres to recovery from illness after 2 months.
Claims (10)
1. treat the Chinese medicine for external application of intercostal neuralgia for one kind, it is characterized in that, in described external preparation, the parts by weight of various raw materials comprise: 10～20 parts of Semen Vaccariae, 10～20 parts of Olibanums, 10～20 parts of Myrrhas, 10～20 parts of Fructus Toosendans, 10～20 parts of Caulis Spatholobis, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Radix Paeoniae Rubra, 10～20 parts of Radix Saposhnikoviaes, 10～20 parts of Radix Notoginseng, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts, Flos Carthami, 10～20 parts of Rhizoma Corydalis, 10～20 parts of Herba Schizonepetae, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Clematidis, 10～20 parts of Eupolyphaga Seu Steleophagas, 10～20 parts of Pheretimas, 10～20 parts of Herba Artemisiae Anomalaes.
2. treat according to claim 1 the Chinese medicine for external application of intercostal neuralgia, it is characterized in that, in described external preparation, the parts by weight of various raw materials comprise: 10～15 parts of Semen Vaccariae, 10～15 parts of Olibanums, 10～15 parts of Myrrhas, 10～15 parts of Fructus Toosendans, 10～15 parts of Caulis Spatholobis, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Radix Paeoniae Rubra, 10～15 parts of Radix Saposhnikoviaes, 10～15 parts of Radix Notoginseng, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts, Flos Carthami, 10～20 parts of Rhizoma Corydalis, 10～20 parts of Herba Schizonepetae, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Clematidis, 10～20 parts of Eupolyphaga Seu Steleophagas, 10～20 parts of Pheretimas, 10～20 parts of Herba Artemisiae Anomalaes.
3. treat according to claim 1 the Chinese medicine for external application of intercostal neuralgia, it is characterized in that, in described external preparation, the parts by weight of various raw materials comprise: 10～20 parts of Semen Vaccariae, 10～20 parts of Olibanums, 10～20 parts of Myrrhas, 10～20 parts of Fructus Toosendans, 10～20 parts of Caulis Spatholobis, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Radix Paeoniae Rubra, 10～20 parts of Radix Saposhnikoviaes, 10～20 parts of Radix Notoginseng, 10～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts, Flos Carthami, 10～15 parts of Rhizoma Corydalis, 10～15 parts of Herba Schizonepetae, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Radix Clematidis, 10～15 parts of Eupolyphaga Seu Steleophagas, 10～15 parts of Pheretimas, 10～15 parts of Herba Artemisiae Anomalaes.
4. a preparation method for the treatment of the Chinese medicine for external application of intercostal neuralgia as described in any one in claim 1～3, is characterized in that, described dosage form is unguentum, and its preparation method comprises:
A, Semen Vaccariae, Olibanum, Myrrha and Radix Notoginseng are distilled into crystallization by the way of distillation, pulverize standbyly, become component 1;
The medicinal residues of b, distillation and surplus stock are put into ethanol and are soaked, and heat is extracted 2 times, become paste, are component 2;
C, above-mentioned two kinds of extracts are merged, be condensed into powder and add vaseline and make unguentum.
5. the preparation method for the treatment of according to claim 4 the unguentum of intercostal neuralgia, is characterized in that, in described step a, Semen Vaccariae, Olibanum, Myrrha and Radix Notoginseng are distilled by the way of distillation, obtain crystal, be ground into fine powder and cross 100-120 mesh sieve, become component 1 standby.
6. treat according to claim 4 the preparation method of the unguentum of intercostal neuralgia, it is characterized in that, in described step b, above-mentioned distilled medicinal residues mix in the ethanol that other surplus stocks add 5-10 doubly to measure and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid,, removes supernatant after standing, and then 100-120 order filters, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000 again, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃; Above-mentioned two kinds of extracting solution are merged, and decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 ℃ 1.08; Being concentrated into relative density is 1.20, the extractum that temperature to 60 is ℃-70 ℃, and stand for standby use, becomes component 2.
7. the preparation method for the treatment of according to claim 4 the unguentum of intercostal neuralgia, is characterized in that, in described step c, the extractum of component 1 and component 2 is merged, then put into concentrating under reduced pressure tank, being evaporated to relative density is 1.20, then take out, mix vaseline paste making agent.
8. a preparation method for the treatment of the Chinese medicine for external application of intercostal neuralgia as described in any one in claim 1～3, is characterized in that, the dosage form of described preparation is unguentum, and preparation method can also be:
A. the crude drug of getting above-mentioned parts by weight is put into Oleum Sesami and is soaked except Semen Vaccariae, Olibanum, Myrrha and Radix Notoginseng; Heating is tempered;
B. Semen Vaccariae, Olibanum, Myrrha and the Radix Notoginseng way of distillation are distilled into crystallization;
C. the crystallization of sieving is put into the medicine oil of tempering, paste making agent.
9. the preparation method for the treatment of according to claim 8 the unguentum of intercostal neuralgia, is characterized in that, the preparation method that the dosage form of described external preparation is unguentum can also be lower step:
In described step a, by the crude drug of described parts by weight, except Semen Vaccariae, Olibanum, Myrrha and Radix Notoginseng, add in the Oleum Sesami of 5-10 times of weight portion and soak 7-10 days; By soaked Oleum Sesami crude drug heating extraction, big fire is boiled, and after Oleum Sesami boiling, firepower reduces, and endures to crude drug appearance and is dark brown, and inner coke yellow, pulls medicinal residues out, medicine oil is continued to temper, and constantly stir, and refining is to dripping into pearl; In described step b, Semen Vaccariae, Olibanum, Myrrha and the Radix Notoginseng way of distillation are distilled into crystallization, and cross 200-300 mesh sieve after being ground into fine powder; In described step c, the crystallization fine powder sieving is put into the medicine oil of tempering, paste making agent but after in impouring cold water, soak 5-10 days, change water every day once, releasing fire-toxin, adds appropriate vaseline paste making agent.
10. according to the Chinese medicine for external application for the treatment of intercostal neuralgia described in claim 1～9, it is characterized in that, described external used medicine dosage form is: unguentum, spray, powder, powder, ointment, gauze agent or emplastrum.
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| CN104623537A (en) * | 2015-01-15 | 2015-05-20 | 汤华淑 | Traditional Chinese medicinal composition for treating intercostal neuralgia |
| CN105147938A (en) * | 2015-10-16 | 2015-12-16 | 韩守江 | Traditional Chinese medicine preparation for treating severe soft tissue injuries |
| CN105213662A (en) * | 2015-09-22 | 2016-01-06 | 夏鲲鹏 | A kind of Chinese medicine composition promoting surgical wounds healing and ease the pain |
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