CN105254563B - 一种荷叶提取物的制备方法 - Google Patents
一种荷叶提取物的制备方法 Download PDFInfo
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- CN105254563B CN105254563B CN201510759184.4A CN201510759184A CN105254563B CN 105254563 B CN105254563 B CN 105254563B CN 201510759184 A CN201510759184 A CN 201510759184A CN 105254563 B CN105254563 B CN 105254563B
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- lotus leaf
- raw material
- lotus
- nuciferine
- extract
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- 240000002853 Nelumbo nucifera Species 0.000 title claims abstract description 50
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- 235000006510 Nelumbo pentapetala Nutrition 0.000 title claims abstract description 48
- 238000002360 preparation method Methods 0.000 title abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 32
- ORJVQPIHKOARKV-OAHLLOKOSA-N nuciferine Chemical compound C1C2=CC=CC=C2C2=C(OC)C(OC)=CC3=C2[C@@H]1N(C)CC3 ORJVQPIHKOARKV-OAHLLOKOSA-N 0.000 claims abstract description 29
- YXVXMURDCBMPRH-UHFFFAOYSA-N Lirinidine Natural products C1C2=CC=CC=C2C2=C(O)C(OC)=CC3=C2C1N(C)CC3 YXVXMURDCBMPRH-UHFFFAOYSA-N 0.000 claims abstract description 28
- ORJVQPIHKOARKV-UHFFFAOYSA-N Nuciferine Natural products C1C2=CC=CC=C2C2=C(OC)C(OC)=CC3=C2C1N(C)CC3 ORJVQPIHKOARKV-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000003513 alkali Substances 0.000 claims abstract description 11
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- 239000000243 solution Substances 0.000 claims description 12
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- 238000010828 elution Methods 0.000 claims description 7
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 6
- 229930003268 Vitamin C Natural products 0.000 claims description 6
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- 239000011718 vitamin C Substances 0.000 claims description 6
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 5
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000003463 adsorbent Substances 0.000 claims description 4
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 229930013930 alkaloid Natural products 0.000 description 5
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- 102000013142 Amylases Human genes 0.000 description 3
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- 108010059892 Cellulase Proteins 0.000 description 3
- 150000003797 alkaloid derivatives Chemical class 0.000 description 3
- 235000019418 amylase Nutrition 0.000 description 3
- 229940106157 cellulase Drugs 0.000 description 3
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- 229960001866 silicon dioxide Drugs 0.000 description 3
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
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- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
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- 238000004128 high performance liquid chromatography Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
荷叶碱(%) | |
实施例1的方法 | 96.85 |
实施例1的方法(但省略海盐水浸润步骤) | 82.67 |
实施例1的方法(但酶解步骤用纤维素酶代替蜗牛酶) | 82.98 |
实施例1的方法(但酶解步骤用淀粉酶代替蜗牛酶) | 73.41 |
实施例1的方法(但酶解步骤用蛋白酶代替蜗牛酶) | 80.16 |
实施例1的方法(但酶解步骤用1:1的纤维素酶:淀粉酶代替蜗牛酶) | 85.39 |
实施例1的方法(但酶解步骤不加维生素C) | 89.87 |
实施例1的方法(但选用大孔树脂柱替换氧化铝柱) | 71.29 |
实施例1的方法(但省略树脂纯化步骤) | 72.05 |
实施例1的方法(但省略模拟移动床精制) | 65.84 |
实施例1的方法(但用干硅胶柱替换模拟移动床精制) | 79.56 |
Claims (1)
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CN201510759184.4A CN105254563B (zh) | 2015-11-10 | 2015-11-10 | 一种荷叶提取物的制备方法 |
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CN105254563B true CN105254563B (zh) | 2017-10-03 |
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Families Citing this family (1)
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CN108094696A (zh) * | 2017-12-27 | 2018-06-01 | 福建光阳蛋业股份有限公司 | 一种蛋鸡荷叶饲料及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101759639A (zh) * | 2010-01-12 | 2010-06-30 | 南京泽朗医药科技有限公司 | 一种从荷叶中制备荷叶碱的方法 |
CN102442949A (zh) * | 2010-10-09 | 2012-05-09 | 苏州宝泽堂医药科技有限公司 | 一种从荷叶中提取荷叶碱的方法 |
CN103159678A (zh) * | 2013-03-26 | 2013-06-19 | 湖南康麓生物科技有限公司 | 一种用于荷叶碱提取的碱析出剂及荷叶碱提取方法 |
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2015
- 2015-11-10 CN CN201510759184.4A patent/CN105254563B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101759639A (zh) * | 2010-01-12 | 2010-06-30 | 南京泽朗医药科技有限公司 | 一种从荷叶中制备荷叶碱的方法 |
CN102442949A (zh) * | 2010-10-09 | 2012-05-09 | 苏州宝泽堂医药科技有限公司 | 一种从荷叶中提取荷叶碱的方法 |
CN103159678A (zh) * | 2013-03-26 | 2013-06-19 | 湖南康麓生物科技有限公司 | 一种用于荷叶碱提取的碱析出剂及荷叶碱提取方法 |
Non-Patent Citations (1)
Title |
---|
高纯度荷叶碱的制备及其药效研究;林木仙等;《福州大学学报(自然科学版)》;20080430;第36卷(第2期);303-307、312 * |
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