CN101856385A - Composition containing echinacea extract and preparation method thereof - Google Patents

Composition containing echinacea extract and preparation method thereof Download PDF

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Publication number
CN101856385A
CN101856385A CN200910131840A CN200910131840A CN101856385A CN 101856385 A CN101856385 A CN 101856385A CN 200910131840 A CN200910131840 A CN 200910131840A CN 200910131840 A CN200910131840 A CN 200910131840A CN 101856385 A CN101856385 A CN 101856385A
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extract
echinacea
echinacea extract
preparation
compositions
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张丽环
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Abstract

The invention discloses a composition containing an echinacea extract and a preparation method thereof. The composition mainly comprises the following components in parts by weight: 1 part of echinacea extract, 2 parts of astragalus membranaceus extract and a little quantity of lutein. The preparation method comprises the following steps of: crushing echinacea raw materials, removing impurity, extracting with ethanol, filtering the extracting solution, concentrating, drying and crushing to obtain the echinacea extract; crushing astragalus membranaceus raw materials , decocting with water to obtain an extractive, carrying out alcohol precipitation on the extractive with the ethanol, drying the precipitate and crushing to obtain an astragalus membranaceus extract; and weighing the extracts by the parts, adding the lutein, and mixing to prepare a preparation of the combination containing the echinacea extract which can accepted by a human body. The composition has favorable function on enhancing the human immunity, improves the taste and the smell of the echinacea extract and is more convenient to take.

Description

The composition and method of making the same that contains Echinacea extract
Technical field
The present invention relates to composition of plant extracts and preparation method thereof, particularly relate to a kind of composition and method of making the same that contains Echinacea extract.
Background technology
Echinacea is the Compositae herbaceos perennial, exactly likes the pipe taper, and growth is all arranged throughout the year, and the gorgeous purple of petal is the outer shape growth of loosing; Pistil is bright yellow; Stem is green, and length has short and thin fur.Find that by seal ground, Plain peace clan it can be used for flu the earliest, have a toothache, venom and other wound etc., back U.S. local nationality are for many years used it as enhance immunity system and the alternative medicine that purifies the blood, particularly in seasonal variations and cold cough pilosity season.1887, it was introduced into U.S.'s Comprehensive Treatment system, and had obtained more deep, careful research.The main component that studies show that Echinacea extract is polysaccharide, caffeic acid derivant and polyphenol, has multiple function, as immunostimulation, anti-infectious function, antiviral, antifungal, effects such as antitumor and antiinflammatory.Wherein being considered to modern study as immunomodulator and immunopotentiating agent confirms, Echinacea extract can produce immunostimulation to T lymphocyte and macrophage, increase the phagocytic activity and the lymphocytic activity of T of macrophage, stimulate macrophage to increase the number of tumor necrosis factor, interferon, interleukin 8 number, destroy tumor cell more.And its toxicological experiment shows that also the toxic and side effects of Echinacea extract is less, and safety is higher, is health product and the plant amedica that world's sales volume ranks forefront therefore.
The Radix Astragali is a leguminous plant, and at the existing very long applicating history of China, the main component of Radix Astragali extract is an astragalus polysaccharides, has the immunity of promotion, improves macrophage activity, suppresses EAS, two-ways regulation blood glucose, and antitumor, antibiotic, the antidotal effect.
The Echinacea product has offensive odour and taste on the one hand, and mouthfeel is relatively poor, and on the other hand, Echinacea and Radix Astragali both have immunoregulation effect, and be also less to the research of its prescription.
Summary of the invention
The purpose of this invention is to provide a kind of composition and method of making the same that contains Echinacea extract,, improve its mouthfeel to improve the immunoregulation effect of Echinacea product.
Technical scheme of the present invention is: a kind of compositions that contains Echinacea extract mainly comprises 1 part of Echinacea extract, 2 parts of Radix Astragali extracts and a small amount of phylloxanthin.Phylloxanthin is a kind of natural; food with double effects (hyperchromic and nutrition); auxiliary pharmaceutical adjuvant; extensively be present in Fructus Musae; Fructus actinidiae chinensis; in the plant such as corn and Flos Tagetis Erectae; belong to a kind of of carotenoid; has lovely luster as pigment; strong coloring force; the effect of safety non-toxic; and as nutrition or functional food; it then mainly is a kind of antioxidant of excellent performance; the activity that can suppress reactive oxygen free radical; stop reactive oxygen free radical to Normocellular destruction; massive epidemiology evidence shows; phylloxanthin has protective effect to vision; and has a prevention cataract; arteriosclerosis; effects such as enhancing immunity take place in the prevention canceration especially; delaying aspects such as cancer development plays an important role.With phylloxanthin and Echinacea extract, the common compatibility of Radix Astragali extract, the immunity of enhancing body has been played better effect.
The preferred lutein content of the present invention is the 1/4-2/3 of the weight portion of Echinacea extract.
The preferred lutein content of the present invention is the 1/3-1/2 of the weight portion of Echinacea extract.
Described compositions can directly or after adding the receivable adjuvant of human body be made capsule, tablet, granule or powder.
Another object of the present invention provides a kind of preparation method of above-mentioned composition, may further comprise the steps:
A) preparation of Echinacea extract: the Echinacea raw material pulverizing, decontamination is used ethanol extraction, the Echinacea extracting solution, with extracting liquid filtering, filtrate concentrates, the concentrated solution spray drying, pulverize Echinacea extract;
B) preparation of Radix Astragali extract: Radix Astragali raw material pulverizing, water decoct, extract, reuse ethanol precipitate with ethanol, drying precipitate, pulverize Radix Astragali extract;
C) take by weighing 1 part of the Echinacea extract of a) step, b) Radix Astragali extract of step is 2 parts, and phylloxanthin 1/4-2/3 part mix homogeneously is made the receivable dosage form of human body.
Described c) preferred 1/3-1/2 part of the phylloxanthin of step.
Use ethanol extraction in the described a) step, ethanol extraction 2-4 time, each 1.5-2 hour.
Described dosage form can directly be made or be added the receivable adjuvant of human body and make capsule, tablet, granule or powder by compositions.Above-mentioned various dosage form all can prepare according to conventional method.
The compositions that contains Echinacea extract of the present invention, with Radix Astragali extract and phylloxanthin together with the Echinacea extract combination formula, to improving body immunity extraordinary effect is arranged, also improved the taste and the abnormal smells from the patient of Echinacea extract simultaneously, take more convenient.
The specific embodiment
Embodiment 1:
A kind of compositions that contains Echinacea extract, preparation according to the following steps:
A) preparation of Echinacea extract: the Echinacea raw material pulverizing, decontamination with ethanol extraction 2 times, extracted 1.5 hours at every turn, the Echinacea extracting solution, with extracting liquid filtering, filtrate concentrates, the concentrated solution spray drying, pulverize Echinacea extract;
B) preparation of Radix Astragali extract: Radix Astragali raw material pulverizing, water decoct, extract, reuse ethanol precipitate with ethanol, drying precipitate, pulverize Radix Astragali extract;
C) take by weighing 1 part of the Echinacea extract of a) step, b) Radix Astragali extract of step is 2 parts, and 1/4 part of mix homogeneously of phylloxanthin adds the needed adjuvant of tablet and makes tablet, and every contains the 0.45g effective ingredient.
Embodiment 2:
A kind of compositions that contains Echinacea extract, preparation according to the following steps:
A) preparation of Echinacea extract: the Echinacea raw material pulverizing, decontamination with ethanol extraction 3 times, extracted 1.5 hours at every turn, the Echinacea extracting solution, with extracting liquid filtering, filtrate concentrates, the concentrated solution spray drying, pulverize Echinacea extract;
B) preparation of Radix Astragali extract: Radix Astragali raw material pulverizing, water decoct, extract, reuse ethanol precipitate with ethanol, drying precipitate, pulverize Radix Astragali extract;
C) take by weighing 1 part of the Echinacea extract of a) step, b) Radix Astragali extract of step is 2 parts, and 1/3 part of mix homogeneously of phylloxanthin is made capsule, contains the 0.45g effective ingredient in every capsules.
Embodiment 3:
A kind of compositions that contains Echinacea extract, preparation according to the following steps:
A) preparation of Echinacea extract: the Echinacea raw material pulverizing, decontamination with ethanol extraction 4 times, extracted 2 hours at every turn, the Echinacea extracting solution, with extracting liquid filtering, filtrate concentrates, the concentrated solution spray drying, pulverize Echinacea extract;
B) preparation of Radix Astragali extract: Radix Astragali raw material pulverizing, water decoct, extract, reuse ethanol precipitate with ethanol, drying precipitate, pulverize Radix Astragali extract;
C) take by weighing 1 part of the Echinacea extract of a) step, b) Radix Astragali extract of step is 2 parts, and 2/3 part of mix homogeneously of phylloxanthin is made powder, contains the 0.45g effective ingredient in every bag of powder.
Embodiment 4:
A kind of compositions that contains Echinacea extract, preparation according to the following steps:
A) preparation of Echinacea extract: the Echinacea raw material pulverizing, decontamination with ethanol extraction 3 times, extracted 2 hours at every turn, the Echinacea extracting solution, with extracting liquid filtering, filtrate concentrates, the concentrated solution spray drying, pulverize Echinacea extract;
B) preparation of Radix Astragali extract: Radix Astragali raw material pulverizing, water decoct, extract, reuse ethanol precipitate with ethanol, drying precipitate, pulverize Radix Astragali extract;
C) take by weighing 1 part of the Echinacea extract of a) step, b) Radix Astragali extract of step is 2 parts, and 1/2 part of mix homogeneously of phylloxanthin is made granule, contains the 0.45g effective ingredient in every bag of granule.
Embodiment 5:
A kind of compositions that contains Echinacea extract, preparation according to the following steps:
A) preparation of Echinacea extract: the Echinacea raw material pulverizing, decontamination with ethanol extraction 3 times, extracted 2 hours at every turn, the Echinacea extracting solution, with extracting liquid filtering, filtrate concentrates, the concentrated solution spray drying, pulverize Echinacea extract;
B) preparation of Radix Astragali extract: Radix Astragali raw material pulverizing, water decoct, extract, reuse ethanol precipitate with ethanol, drying precipitate, pulverize Radix Astragali extract;
C) take by weighing 1 part of the Echinacea extract of a) step, b) Radix Astragali extract of step is 2 parts, and 2/5 part of mix homogeneously of phylloxanthin is made capsule, contains the 0.45g effective ingredient in every capsules.
Embodiment 6: clinical use is observed
Take the capsule that embodiment 5 makes to postoperative patient, every day three times, one time one, took for 5 weeks in succession, its immunocompetence is greatly improved, especially leukocyte raises apparent in viewly, can return to normal value from 3500.
After radiotherapy, take the capsule that embodiment 5 makes for tumor patient, every day three times, one time one, take 2 months in succession after, leukocyte is elevated to 3000.
Give often felt fatigue, people that the working time is long takes the capsule that embodiment 5 makes, every day three times, one time one, after taking 1 month in succession, sensation physical fatigue sense disappears, and comfort and harmony strengthen, and sensation makes moderate progress than the muscle power and the mental status before taking.

Claims (8)

1. a compositions that contains Echinacea extract is characterized in that compositions mainly comprises 1 part of Echinacea extract, 2 parts of Radix Astragali extracts and a small amount of phylloxanthin.
2. the compositions that contains Echinacea extract according to claim 1 is characterized in that lutein content is the 1/4-2/3 of Echinacea extract weight portion.
3. the compositions that contains Echinacea extract according to claim 2 is characterized in that lutein content is the 1/3-1/2 of the weight portion of Echinacea extract.
4. according to each described compositions that contains Echinacea extract of claim 1-3, it is characterized in that making capsule, tablet, granule or powder after the receivable adjuvant of human body directly be made or be added to described compositions can.
5. one kind prepares the method for compositions that contains Echinacea extract, may further comprise the steps:
A) preparation of Echinacea extract: the Echinacea raw material pulverizing, decontamination is used ethanol extraction, the Echinacea extracting solution, with extracting liquid filtering, filtrate concentrates, the concentrated solution spray drying, pulverize Echinacea extract;
B) preparation of Radix Astragali extract: Radix Astragali raw material pulverizing, water decoct, extract, reuse ethanol precipitate with ethanol, drying precipitate, pulverize Radix Astragali extract;
C) take by weighing 1 part of the Echinacea extract of a) step, b) Radix Astragali extract of step is 2 parts, and phylloxanthin 1/4-2/3 part mix homogeneously is made the receivable dosage form of human body.
6. preparation method according to claim 5 is characterized in that described c) preferred 1/3-1/2 part of phylloxanthin in the step.
7. according to claim 5 or 6 each described preparation methoies, it is characterized in that using ethanol extraction in the described a) step ethanol extraction 2-4 time, each 1.5-2 hour.
8. preparation method according to claim 7, it is characterized in that described dosage form can by compositions directly make or add the receivable adjuvant of human body after make capsule, tablet, granule or powder.
CN200910131840A 2009-04-09 2009-04-09 Composition containing echinacea extract and preparation method thereof Pending CN101856385A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102429122A (en) * 2011-11-18 2012-05-02 青岛农业大学 Immunity-improving vegetable feed additive for sheep
CN102839206A (en) * 2012-09-15 2012-12-26 闫利琴 Preparation method for promoting self generation of human bone marrow hematopoietic stem cells
CN112691135A (en) * 2021-02-06 2021-04-23 江南大学 Anti-tumor traditional Chinese medicine composition and application thereof
CN113069481A (en) * 2021-05-11 2021-07-06 华南农业大学 Application of echinacea purpurea extract in preparation of drugs for preventing and/or treating damp-heat diarrhea

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1704085A (en) * 2004-06-04 2005-12-07 成都地奥制药集团有限公司 Pharmaceutical composition with immunoregulation function and method for preparing the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1704085A (en) * 2004-06-04 2005-12-07 成都地奥制药集团有限公司 Pharmaceutical composition with immunoregulation function and method for preparing the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
李雅慧; 董诗源; 余超,等: "《叶黄素在食品中的研究与应用》", 《营养与食品——健康中国高级论坛Ⅱ论文集》 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102429122A (en) * 2011-11-18 2012-05-02 青岛农业大学 Immunity-improving vegetable feed additive for sheep
CN102429122B (en) * 2011-11-18 2012-11-21 青岛农业大学 Immunity-improving vegetable feed additive for sheep
CN102839206A (en) * 2012-09-15 2012-12-26 闫利琴 Preparation method for promoting self generation of human bone marrow hematopoietic stem cells
CN102839206B (en) * 2012-09-15 2014-06-11 闫利琴 Preparation method for promoting self generation of human bone marrow hematopoietic stem cells
CN112691135A (en) * 2021-02-06 2021-04-23 江南大学 Anti-tumor traditional Chinese medicine composition and application thereof
CN112691135B (en) * 2021-02-06 2022-03-25 江南大学 Anti-tumor traditional Chinese medicine composition and application thereof
CN113069481A (en) * 2021-05-11 2021-07-06 华南农业大学 Application of echinacea purpurea extract in preparation of drugs for preventing and/or treating damp-heat diarrhea

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Application publication date: 20101013