CN105194482A - Medicine preparation for treating chronic nephrosis - Google Patents
Medicine preparation for treating chronic nephrosis Download PDFInfo
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- CN105194482A CN105194482A CN201510771202.0A CN201510771202A CN105194482A CN 105194482 A CN105194482 A CN 105194482A CN 201510771202 A CN201510771202 A CN 201510771202A CN 105194482 A CN105194482 A CN 105194482A
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Abstract
The invention relates to a medicine preparation for treating chronic nephrosis. The medicine preparation is prepared from the following raw materials: epimedium, obovate ainsliaea, polygonum multiflorum, lonicera japonica, myrrh, dandelion, herba artemisiae scopariae, coptis chinensis, kudzu vine root, radix dipsaci, radix achyranthis bidentatae, radix stemonae, cinnamon, rhizoma atractylodis, radix paeoniae alba, Chinese yam, gingko leaves, burdock, rohdea japonica, pepper, manyprickle acanthopanax root, rhizoma acori graminei, cortex phellodendri, rhizoma alismatis and peach kernels. The medicine preparation can be used for treating both symptoms and root causes of chronic nephrosis, has the advantages of exact curative effect, strict prescription and convenient preparation, and has a wide application prospect.
Description
Technical field
The invention belongs to motherland's medical medicine technical field, concrete, relating to a kind of take Chinese herbal medicine as the pharmaceutical preparation of raw material for chronic nephropathy.
Background technology
Nephropathy, between viscera, all remains dynamic equilibrium between environment and external environment.If the multiple paathogenic factor in the interior external world destroys the balance of human body, cause internal organs QI and blood functional disorder, sick and in kidney, then cause the generation of kidney disease.The prerequisite of morbidity, in the power with human righteousness, and evil orthogonally strives the situation with both sides' prosperity and decline.Cause the cause of disease of kidney disease varied, as the multiple internal and external factors such as six climate exopathogens, seven emotions, diet, work and rest, exhaustion due to sexual indulgence, poison of drug, unexpected injury all can cause a disease.Further, at generation, the evolution process of disease, the cause of disease and its pathological product often interact, reciprocal causation.In clinical, be diagnosed as glomerulonephritis, latent nephritis, pyelonephritis, Henoch Schonlein purpura nephritis, lupus erythematosus nephritis, gout kidney, iga nephropathy, nephrotic syndrome, membranous nephropathy, nephrotic syndrome, diabetic nephropathy, hypertensive nephropathy, polycystic kidney, etc., when the morbidity delay of these nephropathy is difficult, time was more than three months, patient urine and relevant physiochemical indice occur abnormal, Renal Paphology, iconography note abnormalities, or the glomerule effective filtration rate of kidney is lower than 60%, all can be referred to as " chronic nephropathy ".Chronic nephropathy is as failed timely and effective treatment, and the progress that causes that sb.'s illness took a turn for the worse, then with course of disease delay, Patients with Chronic Renal Disease will develop into chronic renal insufficiency, renal failure, finally form uremia.
Chronic nephropathy is not subject to everybody enough attention all the time, but when it develops into renal failure-uremia, its harm not second to cancer, and causes the nephropathy of China also to rise due to treatment lack of standardization, Drug abuse and bad life style year after year.The main manifestations of chronic nephropathy has: (1) edema; (2) hypertension; (3) pain over renal region and renal colic; (4) urinary irritation symptoms (i.e. urgent micturition, dysurea, frequent micturition); (5) paruria (comprises hypourocrinia, albuminuria, hematuria, cylinderuria, leukocyturia, pyuria and bacteriuria, the kidney function test positive etc.According to array incomplete data statistics, Chronic glomerular disease is in the prevalence about 1 ~ 2% of China.In recent years, nephropathy sickness rate also has the trend constantly raised.
Doctor trained in Western medicine applies hormone therapy usually for chronic nephropathy, its therapeutic outcome is mainly effective to minute lesion type nephritis, and other type uncertain therapeutic efficacy is surely even invalid, but thing followed side effect, as edema obesity, acne, secondary infection, sclerotin breakage etc., bring catastrophic effect to patient; The patient that renal function is badly damaged is more difficult in treatment, the therapy such as conventional dialysis and renal transplantation clinically, dialysis can only sustain life, and produce dependency and dialysis syndrome, renal transplantation success rate is low, and rejection is also difficult to solve for the moment, and hormonotherapy side effect is obvious, and easily recur, the somewhat expensive of dialysis and renal transplantation in addition often makes numerous patients be difficult to bear.
Chinese medicine thinks that the kidney being the origin of congenital constitution, and residence has Kidney-Yin (kidney yin), Yuanyang (kidney yang), store essential substances, Si Eryin, with bladder the exterior and the interior each other.The kidney said with doctor trained in Western medicine is not the same thing, and the kidney of doctor trained in Western medicine is a dissection concept, is positioned at the Semen Viciae fabae sample organ of posterior spinal both sides, abdominal cavity, left and right each.The kidney of the traditional Chinese medical science is more it is emphasised that function, and water as main in kidney, is namely responsible for the water liquid metabolism of human body, by the gasification of kidney yang, participates in the metabolism of water liquid play a leading role to lung, spleen, bladder etc.And chronic nephritis is mainly because of being invaded by exogenous pathogen, overstrain internal injury or drinking and eating irregularly, make gas unfavorable, the defeated cloth of body fluid is not normal, causes water retention, overflows to cause in skin to carry on the back even anasarca etc. with women's head-ornaments, eyelid, extremity, abdomen, it is returned to arrive internal organs, mainly lung, spleen, kidney three are dirty, at " Jing Yue's complete work, swelling " cloud: " card such as all edema is lung, spleen, the dirty relevant disease of kidney three; lid water is Zhiyin, the fundamental cause of water disease being in the kidney; Aquation is in gas, therefore it is marked on lung; Water only fears soil, therefore it is built in spleen.The modern deficiency of the lung then vital QI failing to transform into essence and change water, insufficiency of the spleen then the spleen failing to restrict the kidney and anti-gram, suffer from a deficiency of the kidney then water without main and absurd row." more brilliantly refer to be derived the dirty relation with edema syndrome of spleen, lung, kidney three, if kidney qi is more empty, pathogenic water is more contained; contrary, lung by evil and import kidney into time, also can cause equifinality; meanwhile, can not controlling the water circulation if insufficiency of the spleen between spleen kidney, water is wet to be stopped up very; must damage its sun; therefore insufficiency of the spleen further developing, and kidney yang must be caused also to decline, if decline of kidney-YANG; can not replenishing vital QI with drugs of warm nature spleen soil, then can make edema more very.Therefore the dirty morbidity with edema of lung, spleen, kidney three, take kidney as this, take lung as mark, and be the dirty of controlling the water circulation with spleen, and real is the key point of edema pathogenesis, and in addition, the pathogenesis of edema and the heart, liver two are dirty also closely related.
In recent years, Chinese traditional treatment nephropathy achieves significant progress, generally believes, nephropathy is a kind of card of deficiency in origin and excess in superficiality, and Therapeutic Method has based on righting, as invigorating the lung and the kidney method, and strengthening spleen, tonifying kidney method, nourishing the liver and kidney method etc.; Have and control so that strengthening vital QI to eliminate pathogenic factors is double, as spleen invigorating eliminating dampness by diuresis method, Blood rheology, warming YANG activating blood circulation method, nourishing yin and activating blood method etc.; Also have based on eliminating evil method for the treatment of, as clearing away heat-damp and promoting diuresis method, activating blood and removing stasis Method etc., but prior art prescription lacks dialectical, and treatment cycle is long, suiting the medicine to the illness property is not strong, and curative effect is not obvious, even also can bring side effect to patient, increases patient suffering.
Summary of the invention
The object of this invention is to provide a kind for the treatment of both the principal and secondary aspects of a disease, have no side effect, the pure traditional Chinese compound medicine of safe ready.
Object of the present invention is exactly to solve problems of the prior art, in conjunction with the integrated Empirical formula of forefathers, according to doctor's row practice for many years, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways the length of many families is collected, seek therapeutic regimen, from motherland's medical treasure-house, filter out the diuretic that dispels the wind, heat-clearing and toxic substances removing, training spleen reinforcing kidney, the natural Chinese medicine of blood circulation promoting and blood stasis dispelling, by theory of Chinese medical science prescription, skim the cream off milk, pharmaceutical preparation of the present invention is meticulously mixed with in conjunction with Traditional Chinese Medicine technology, it is rapid-action, effect is strong, short treating period, safety is high, without obvious toxic-side effects, medication is simple, to chronic nephropathy determined curative effect.
For achieving the above object, the technical solution used in the present invention is as follows:
For a pharmaceutical preparation for chronic nephropathy, it is prepared by following raw material and obtains:
Herba Epimedii, Herba Ainsliaeae ovovatae, Radix Polygoni Multiflori, Flos Lonicerae, Myrrha, Herba Taraxaci, Herba Artemisiae Scopariae, Rhizoma Coptidis, Radix Puerariae, Radix Dipsaci, Radix Achyranthis Bidentatae, the Radix Stemonae, Cortex Cinnamomi, Rhizoma Atractylodis, the Radix Paeoniae Alba, Rhizoma Dioscoreae, Folium Ginkgo, Fructus Arctii, Rohdea japonica Roth, Pericarpium Zanthoxyli, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Acori Graminei, Cortex Phellodendri, Rhizoma Alismatis, Semen Persicae.
Preferably, the present invention is used for the pharmaceutical preparation of chronic nephropathy, and it is prepared by the raw material of following weight and obtains:
Herba Epimedii 33-40 part, Herba Ainsliaeae ovovatae 33-40 part, Radix Polygoni Multiflori 33-40 part, Flos Lonicerae 30-35 part, Myrrha 30-35 part,
Herba Taraxaci 30-35 part, Herba Artemisiae Scopariae 25-30 part, Rhizoma Coptidis 25-30 part, Radix Puerariae 25-30 part, Radix Dipsaci 25-30 part,
Radix Achyranthis Bidentatae 20-25 part, Radix Stemonae 20-25 part, Cortex Cinnamomi 20-25 part, Rhizoma Atractylodis 20-25 part, Radix Paeoniae Alba 18-20 part,
Rhizoma Dioscoreae 18-20 part, Folium Ginkgo 18-20 part, Fructus Arctii 18-20 part, Rohdea japonica Roth 15-18 part, Pericarpium Zanthoxyli 15-18 part,
Radix Et Caulis Acanthopanacis Senticosi 15-18 part, Rhizoma Acori Graminei 10-15 part, Cortex Phellodendri 10-15 part, Rhizoma Alismatis 10-15 part, Semen Persicae 10-15 part.
The preparation method of described pharmaceutical preparation is: for subsequent use according to weight weighting raw materials
(1) get Herba Epimedii, Herba Ainsliaeae ovovatae, Radix Polygoni Multiflori, Rhizoma Coptidis, Radix Puerariae, Cortex Cinnamomi, the Radix Paeoniae Alba, Rhizoma Dioscoreae, Cortex Phellodendri, Semen Persicae decoct with water, first time adds 5 times of weight water, decoct 2 hours, filtrate and medicinal residues are obtained after filtration, medicinal residues are added 3 times of weight water and decoct 1 hour, merging filtrate after filtering, the filtrate after merging is condensed into the extractum that density is 1.2g/ml, after 60 DEG C of dryings, pulverize and obtain composition A;
(2) get surplus stock and add 3 times of weight 75%(volume ratios) ethanol, reflux, extract, 2 times, each 1 hour, extracting solution merged, and is concentrated into the extractum that density is 1.2g/ml, after 60 DEG C of dryings, pulverized and obtained composition B;
(3) Homogeneous phase mixing composition A and composition B, in incapsulating, sterilization obtains capsule product, each oral 1g, three times on the one.
The component of medicine of the present invention all adopts natural raw material of Chinese medicine, and its preparation is easy, and medicine source is extensive, with low cost, it follows the prescriptions principle of the traditional Chinese medical science, has effect of the diuretic that dispels the wind, heat-clearing and toxic substances removing, training spleen reinforcing kidney, blood circulation promoting and blood stasis dispelling, improves renal blood flow amount, reduce urine protein, delay renal damage, reliably evident in efficacy to chronic nephritis, mild in medicine property and, there is not toxic and side effects, have a extensive future.
Detailed description of the invention
Embodiment 1
For a pharmaceutical preparation for chronic nephropathy, it is prepared by the raw material of following weight and obtains:
Herba Epimedii 33 parts, Herba Ainsliaeae ovovatae 33 parts, Radix Polygoni Multiflori 33 parts, Flos Lonicerae 30 parts, Myrrha 30 parts,
Herba Taraxaci 30 parts, Herba Artemisiae Scopariae 25 parts, Rhizoma Coptidis 25 parts, Radix Puerariae 25 parts, Radix Dipsaci 25 parts,
Radix Achyranthis Bidentatae 20 parts, the Radix Stemonae 20 parts, Cortex Cinnamomi 20 parts, Rhizoma Atractylodis 20 parts, the Radix Paeoniae Alba 18 parts,
Rhizoma Dioscoreae 18 parts, Folium Ginkgo 18 parts, Fructus Arctii 18 parts, Rohdea japonica Roth 15 parts, 15 parts, Pericarpium Zanthoxyli,
Radix Et Caulis Acanthopanacis Senticosi 15 parts, Rhizoma Acori Graminei 10 parts, Cortex Phellodendri 10 parts, Rhizoma Alismatis 10 parts, 10 parts, Semen Persicae.
The preparation method of described pharmaceutical preparation is: for subsequent use according to weight weighting raw materials
(1) get Herba Epimedii, Herba Ainsliaeae ovovatae, Radix Polygoni Multiflori, Rhizoma Coptidis, Radix Puerariae, Cortex Cinnamomi, the Radix Paeoniae Alba, Rhizoma Dioscoreae, Cortex Phellodendri, Semen Persicae decoct with water, first time adds 5 times of weight water, decoct 2 hours, filtrate and medicinal residues are obtained after filtration, medicinal residues are added 3 times of weight water and decoct 1 hour, merging filtrate after filtering, the filtrate after merging is condensed into the extractum that density is 1.2g/ml, after 60 DEG C of dryings, pulverize and obtain composition A;
(2) get surplus stock and add 3 times of weight 75%(volume ratios) ethanol, reflux, extract, 2 times, each 1 hour, extracting solution merged, and is concentrated into the extractum that density is 1.2g/ml, after 60 DEG C of dryings, pulverized and obtained composition B;
(3) Homogeneous phase mixing composition A and composition B, in incapsulating, sterilization obtains capsule product, each oral 1g, three times on the one.
Embodiment 2
For a pharmaceutical preparation for chronic nephropathy, it is prepared by the raw material of following weight and obtains:
Herba Epimedii 40 parts, Herba Ainsliaeae ovovatae 40 parts, Radix Polygoni Multiflori 40 parts, Flos Lonicerae 35 parts, Myrrha 35 parts,
Herba Taraxaci 35 parts, Herba Artemisiae Scopariae 30 parts, Rhizoma Coptidis 30 parts, Radix Puerariae 30 parts, Radix Dipsaci 30 parts,
Radix Achyranthis Bidentatae 25 parts, the Radix Stemonae 25 parts, Cortex Cinnamomi 25 parts, Rhizoma Atractylodis 25 parts, the Radix Paeoniae Alba 20 parts,
Rhizoma Dioscoreae 20 parts, Folium Ginkgo 20 parts, Fructus Arctii 20 parts, Rohdea japonica Roth 18 parts, 18 parts, Pericarpium Zanthoxyli,
Radix Et Caulis Acanthopanacis Senticosi 18 parts, Rhizoma Acori Graminei 15 parts, Cortex Phellodendri 15 parts, Rhizoma Alismatis 15 parts, 15 parts, Semen Persicae.
The preparation method of described pharmaceutical preparation is: for subsequent use according to weight weighting raw materials
(1) get Herba Epimedii, Herba Ainsliaeae ovovatae, Radix Polygoni Multiflori, Rhizoma Coptidis, Radix Puerariae, Cortex Cinnamomi, the Radix Paeoniae Alba, Rhizoma Dioscoreae, Cortex Phellodendri, Semen Persicae decoct with water, first time adds 5 times of weight water, decoct 2 hours, filtrate and medicinal residues are obtained after filtration, medicinal residues are added 3 times of weight water and decoct 1 hour, merging filtrate after filtering, the filtrate after merging is condensed into the extractum that density is 1.2g/ml, after 60 DEG C of dryings, pulverize and obtain composition A;
(2) get surplus stock and add 3 times of weight 75%(volume ratios) ethanol, reflux, extract, 2 times, each 1 hour, extracting solution merged, and is concentrated into the extractum that density is 1.2g/ml, after 60 DEG C of dryings, pulverized and obtained composition B;
(3) Homogeneous phase mixing composition A and composition B, in incapsulating, sterilization obtains capsule product, each oral 1g, three times on the one.
Embodiment 3
Clinical data
Observe case and be the patient that is hospitalized for treatment, choose and be in hospital in March ,-2015 in January, 2013 and outpatient service patients with chronic glomerulonephritis 136 example, male 70 example, women 66 example, 33 ~ 65 years old age.Be divided into three groups at random, matched group 46 example, embodiment 1 group of 45 example, embodiment 2 group of 45 example, the equal not statistically significants of difference (P<0.05) such as three groups of sexes, age, courses of disease, have comparability.
Diagnostic criteria
With reference to the diagnostic criteria of the national academic conference revision of Nanjing the 2nd, nephropathy association of China in 1985.
(1) onset is slow, protracted inflammation, time light time heavy, renal function is faded, and the later stage can occur anemia, electrolyte disturbance, the situations such as blood urea nitrogen, serum creatinine rising.
(2) performances such as albuminuria in various degree, hematuria, edema and hypertension are had.
(3) acute attack can be brought out because of reasons such as respiratory tract infection in the state of an illness, occur the performance of similar acute nephritis, also have some cases can have the automatic catabasis.
Therapeutic Method
Matched group: adopt doctor trained in Western medicine routine orally taken for curing to the ill, adopt prednisone 1mg/Kg, morning, 1 decoction being taken at a draught, was used in conjunction 8 weeks, decrement gradually, has the infected, infection control, but avoid using renal damage medicine, have hyperpietic, select ACEI preparation or calcium antagonist and high quality protein diet etc.
Embodiment 1 group: give pharmaceutical preparation prepared by embodiment 1, each oral 1g, three times on the one, surrounding is a course for the treatment of, treatments period, can give and antibiotic infection control, continuous hypertension person adds appropriate depressor.
Embodiment 2 groups: give pharmaceutical preparation prepared by embodiment 2, each oral 1g, three times on the one, surrounding is a course for the treatment of, treatments period, can give and antibiotic infection control, continuous hypertension person adds appropriate depressor.
Criterion of therapeutical effect treats 3 courses for the treatment of: " the new Chinese medicine guideline of clinical investigations " issued according to Ministry of Public Health in 1996:
Effective: the tired transference cure of edema, the soreness of waist, oliguria, limb, the qualitative feminine gender of urine protein, twenty-four-hour urine protein quantification < 200mg, under high power lens, urine erythrocyte disappears, normal renal function.
Effective: the tired symptom of edema, the soreness of waist, oliguria, limb obviously alleviates, the qualitative continuous decrease > 50% of urine protein, under high power lens, urine erythrocyte is a small amount of, normal renal function or close normal.
Invalid: symptom without alleviating, the qualitative decline < 50% of urine protein.
Clinical efficacy is in table 1:
Table 1
Group | Number of cases | Effective | Effectively | Invalid | Total effective rate |
Matched group | 46 | 18 | 13 | 15 | 67% |
Embodiment 1 group | 45 | 28 | 15 | 2 | 95.5% |
Embodiment 2 groups | 45 | 27 | 17 | 1 | 97.7% |
Through statistical analysis, all there is extremely significant difference with matched group in embodiment 1 and embodiment 2 groups on clinical efficacy,
Embodiment 4
Model case
Cao, man 55 years old, occur with albuminuria hematuria, renal fibroblast shows: slight mesangial matrix *, twenty-four-hour urine albumen 1.5g/24h, white and thin fur is greasy, matter is partially red, arteries and veins is soft, adopt hormone therapy, because side effect is larger, patient refuses continual cure, give pharmaceutical preparation prepared by embodiment 1, each oral 1g, three times on the one, surrounding is a course for the treatment of, after the course for the treatment of, symptom is significantly alleviated, advise to continue and take a course for the treatment of, the soreness of waist, oliguria transference cure, the qualitative feminine gender of urine protein, twenty-four-hour urine protein quantification < 200mg, under high power lens, urine erythrocyte disappears, normal renal function, follow up a case by regular visits to half a year without recurrence.
What more than enumerate is only best specific embodiment of the present invention.Obviously, the invention is not restricted to above embodiment, many distortion can also be had.All distortion that those of ordinary skill in the art can directly derive from content disclosed by the invention or associate, all should think protection scope of the present invention.
Claims (4)
1., for a pharmaceutical preparation for chronic nephropathy, it is prepared by following raw material and obtains:
Herba Epimedii, Herba Ainsliaeae ovovatae, Radix Polygoni Multiflori, Flos Lonicerae, Myrrha, Herba Taraxaci, Herba Artemisiae Scopariae, Rhizoma Coptidis, Radix Puerariae, Radix Dipsaci, Radix Achyranthis Bidentatae, the Radix Stemonae, Cortex Cinnamomi, Rhizoma Atractylodis, the Radix Paeoniae Alba, Rhizoma Dioscoreae, Folium Ginkgo, Fructus Arctii, Rohdea japonica Roth, Pericarpium Zanthoxyli, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Acori Graminei, Cortex Phellodendri, Rhizoma Alismatis, Semen Persicae.
2. pharmaceutical preparation according to claim 1, is characterized in that, described pharmaceutical preparation is prepared by the raw material of following weight proportioning and obtains:
Herba Epimedii 33 parts, Herba Ainsliaeae ovovatae 33 parts, Radix Polygoni Multiflori 33 parts, Flos Lonicerae 30 parts, Myrrha 30 parts,
Herba Taraxaci 30 parts, Herba Artemisiae Scopariae 25 parts, Rhizoma Coptidis 25 parts, Radix Puerariae 25 parts, Radix Dipsaci 25 parts,
Radix Achyranthis Bidentatae 20 parts, the Radix Stemonae 20 parts, Cortex Cinnamomi 20 parts, Rhizoma Atractylodis 20 parts, the Radix Paeoniae Alba 18 parts,
Rhizoma Dioscoreae 18 parts, Folium Ginkgo 18 parts, Fructus Arctii 18 parts, Rohdea japonica Roth 15 parts, 15 parts, Pericarpium Zanthoxyli,
Radix Et Caulis Acanthopanacis Senticosi 15 parts, Rhizoma Acori Graminei 10 parts, Cortex Phellodendri 10 parts, Rhizoma Alismatis 10 parts, 10 parts, Semen Persicae.
3. pharmaceutical preparation according to claim 1, is characterized in that, the preparation method of described pharmaceutical preparation comprises the steps:
For subsequent use according to weight weighting raw materials;
(1) Herba Epimedii, Herba Ainsliaeae ovovatae, Radix Polygoni Multiflori, Rhizoma Coptidis, Radix Puerariae, Cortex Cinnamomi, the Radix Paeoniae Alba, Rhizoma Dioscoreae, Cortex Phellodendri, Semen Persicae is got, mixing, decocts with water, and first time adds 5 times of weight water, decoct 2 hours, obtain filtrate and medicinal residues after filtration, medicinal residues are added 3 times of weight water and decoct 1 hour, after filtration, obtain filtrate, merge twice filtrate, filtrate after merging is condensed into the extractum that density is 1.2g/ml, after 60 DEG C of dryings, pulverizes and obtain composition A;
(2) get surplus stock, mixing, add the ethanol of 3 times of weight 75%, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the extractum that density is 1.2g/ml, after 60 DEG C of dryings, pulverizes and obtains composition B;
(3) Homogeneous phase mixing composition A and composition B, to obtain final product.
4. pharmaceutical preparation described in claim 1-3 is used for the purposes of chronic nephropathy.
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CN106492017A (en) * | 2016-11-18 | 2017-03-15 | 广西大学 | A kind of treat Chinese medicine preparation of hypertensive nephropathy and preparation method thereof |
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Non-Patent Citations (2)
Title |
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李文瑞等: "《中药别名辞典》", 30 September 1994, 中国科学技术出版社 * |
王珣等: "慢性肾炎组方配伍规律的探讨", 《陕西中医》 * |
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CN106492017A (en) * | 2016-11-18 | 2017-03-15 | 广西大学 | A kind of treat Chinese medicine preparation of hypertensive nephropathy and preparation method thereof |
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