CN106880828A

CN106880828A - A kind of Chinese medicine composition for treating spleen kidney qi deficiency of yang type primary nephrotic syndrome

Info

Publication number: CN106880828A
Application number: CN201710226391.2A
Authority: CN
Inventors: 张鹏
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-04-09
Filing date: 2017-04-09
Publication date: 2017-06-23

Abstract

The invention discloses a kind of medicine, a kind of Chinese medicine composition for treating spleen kidney qi deficiency of yang type primary nephrotic syndrome is particularly disclosed.The Chinese medicine composition of the treatment spleen kidney qi deficiency of yang type primary nephrotic syndrome, it is characterized in that：The weight proportion of each raw material is：30 parts of Radix Codonopsis, 30 parts of the Radix Astragali, 30 parts of the bighead atractylodes rhizome, 30 parts of Poria cocos, 15 parts of rhizoma alismatis, 30 parts of rde bean, 15 parts of umbellate pore furgus, 30 parts of corn stigma, 15 parts of cooked aconite, 15 parts of charred RADIX ET RHIZOMA RHEI, 15 parts of charred POLLEN TYPHAE, 15 parts of rhizoma zingiberis, 15 parts of Morinda officinalis, 25 parts of barrenwort, 15 parts of Psoralea corylifolia, 15 parts of dried orange peel, 15 parts of lotus seeds, 15 parts of Gorgon fruit.The present invention, come strengthening vital QI to eliminate pathogenic factors, regulation equilibrium between yin and yang, reaches the effect for the treatment of spleen kidney qi deficiency of yang type primary nephrotic syndrome by tonifying middle-Jiao and Qi, dampness removing infiltration, warm kidney Guyang.Its is evident in efficacy, significantly reduces patient suffering, and recurrence rate is decreased obviously, and improves the quality of life of patient；And its toxic and side effect is relatively small, patient can feel at ease to take.Chinese medicine of the invention, good effect, instant effect has no side effect, and total effective rate is up to 96.6%.

Description

A kind of Chinese medicine composition for treating spleen kidney qi deficiency of yang type primary nephrotic syndrome

Technical field

The invention mainly relates to the field of Chinese medicines, a kind of spleen kidney qi deficiency of yang type primary nephrotic syndrome for the treatment of is related generally to Chinese medicine composition.

Background technology

Primary nephrotic syndrome refer to by primary glomerulopathy cause with High-grade Proteinuria, Hypoproteinemia, The clinical syndrome group that hyperlipidemia and different degrees of oedema etc. are characterized.Its cause of disease is complicated, and mechanism is not yet fully apparent from.It is modern Medical science carries out medication and makes prognosis according to the histological type of patient, clinical manifestation and Physico-chemical tests index；And Chinese traditional treatment is then Based on diagnosis and treatment, its assertive evidence is typically divided into qi deficiency of lung and kidney, the insufficiency of both the spleen and the kindey, the deficiency of liver-yin and kidney-yin, the type of deficiency of both qi and yin four, standard card It is divided into diseases caused by external factors, damp and hot, blood stasis, wet turbid four type to be treated（See what health ministry was formulated《New Chinese medicine treats nephrotic syndrome Guideline of clinical investigations》）.Exclusive one group of tcm syndrome group is speen-kidney dificiency actually in Adult Primary Nephrotic Syndrome Card, group is very common in Adult Primary Nephrotic Syndrome for the syndrome.It is further divided into four secondary syndromes：Syndrome of yang deficiency of spleen and kidney, Spleen kidney qi yang deficiency syndrome, spleen kidney qi yin deficiency syndrome, unrising of splenoqi and nephrasthenia syndrome.Medicine of the present invention is only applicable to spleen kidney qi yang deficiency syndrome person.

The content of the invention

The object of the invention is exactly to make up treatment spleen kidney qi deficiency of yang type primary nephrotic syndrome Western medicine, middle medication at present Effect is not good enough, easily defect repeatedly, there is provided a kind of Chinese traditional medicine composition of special for treating spleen kidney qi deficiency of yang type primary nephrotic syndrome Thing, it is obvious for treatment spleen kidney qi deficiency of yang type primary nephrotic syndrome curative effect, and obvious effective rate is high, and concurrent HSPN is few, Small side effects, safe ready.

The present invention is achieved by the following technical solutions：

A kind of Chinese medicine composition for treating spleen kidney qi deficiency of yang type primary nephrotic syndrome, it is characterised in that matched somebody with somebody by following weight The material medicine composition of ratio：Radix Codonopsis 20-40 parts, Radix Astragali 20-40 parts, bighead atractylodes rhizome 20-40 parts, Poria cocos 20-40 parts, rhizoma alismatis 10-20 parts, Rde bean 20-40 parts, umbellate pore furgus 10-20 parts, corn stigma 20-40 parts, cooked aconite 10-20 parts, charred RADIX ET RHIZOMA RHEI 10-20 parts, charred POLLEN TYPHAE 10- 20 parts, rhizoma zingiberis 10-20 parts, Morinda officinalis 10-20 parts, barrenwort 20-30 parts, Psoralea corylifolia 10-20 parts, dried orange peel 10-20 parts, lotus seeds 10-20 parts, Gorgon fruit 10-20 parts.

A kind of Chinese medicine composition for treating spleen kidney qi deficiency of yang type primary nephrotic syndrome, it is preferred, by following weight The material medicine composition of proportioning：30 parts of Radix Codonopsis, 30 parts of the Radix Astragali, 30 parts of the bighead atractylodes rhizome, 30 parts of Poria cocos, 15 parts of rhizoma alismatis, 30 parts of rde bean, pig 15 parts of Siberian cocklebur, 30 parts of corn stigma, 15 parts of cooked aconite, 15 parts of charred RADIX ET RHIZOMA RHEI, 15 parts of charred POLLEN TYPHAE, 15 parts of rhizoma zingiberis, 15 parts of Morinda officinalis, barrenwort 25 parts, 15 parts of Psoralea corylifolia, 15 parts of dried orange peel, 15 parts of lotus seeds, 15 parts of Gorgon fruit.

Compound method of the invention is as follows：Medicinal cold water soak is decocted after 1 hour in will be above-mentioned, is decocted moisture content and is exceeded Chinese medicine 2-3 centimeters, with being cooked by slow fire 50 minutes after boiling water, liquid is poured out in filtering.

Specific embodiment

A kind of Chinese medicine composition for treating spleen kidney qi deficiency of yang type primary nephrotic syndrome, it is preferred, by following weight The material medicine composition of proportioning：Radix Codonopsis 30g, Radix Astragali 30g, bighead atractylodes rhizome 30g, Poria cocos 30g, rhizoma alismatis 15g, rde bean 30g, umbellate pore furgus 15g, Corn stigma 30g, cooked aconite 15g, charred RADIX ET RHIZOMA RHEI 15g, charred POLLEN TYPHAE 15g, rhizoma zingiberis 15g, Morinda officinalis 15g, barrenwort 25g, Psoralea corylifolia 15g, dried orange peel 15g, lotus seeds 15g, Gorgon fruit 15g.

The raw material components of above correspondence group are weighed, is added water to cook according to the routine fashion of decoction of medicinal ingredients, be cooked into decoction and take.

One one, and half an hour takes after meal sooner or later in two times.

Clinical observation

1 physical data

Selected case is in January, 2015 in December, 2016 inpatient department of Nephrology dept. of hospital and traditional chinese medical science clinic case, treatment group 30, control group 20.All cases are the case of first attack and treatment.In treatment group 30, the age is minimum 18 years old, most Big 63 years old, the age is in 18-45 year persons 17,46-65 year persons 13；Wherein, male 20, women 10.In control group 20, Minimum 19 years old of age, maximum 65 years old, the age is in 18-45 year persons 7,46-65 year persons 13；Wherein, male 12, women 8. Two groups of sex, the age, there was no significant difference（Throughx2 inspections,p＞ 0.05）, with comparativity.

2 diagnostic criteria

2.1 Western medicine diagnostic criterias

With reference to the standard of the revision of Second China National ephrosis academic conference in 1985：All primary glomerulopathies occur:（1）Largely Albuminuria（24h Urine proteins are more than 3.5g）；（2）Hypoproteinemia（Plasma albumin is less than 30g/L）；（3）Obvious oedema；（4） Hyperlipidemia.Wherein（1）、（2）Item is necessary requirement.

The asthenic symptoms CM syndrome differentiation criterion of 2.2 TCM Spleen kidney two

The parting standard extension modification formulated with reference to the national Chinese Medical Nephrosis third session held for 1986 is included:（1）Complexion It is white, the cold limb of shape is cold；（2）Waist and knee crymodynia；（3）Indigestion and loss of appetite, big loose stool is thin, tastelessness and no thirst；（4）Tongue body is light fat, and indented tongue margin, tongue is white Or neatly；（5）Deep,thready and forceless pulse, or it is heavy slow, it is obvious with right chi pulse.5 points of the above meets at 4 points.

3 curative effect determinate standards

Formulated according to the Ministry of Public Health《New Chinese medicine treats nephrotic syndrome guideline of clinical investigations》Formulate：

Complete incidence graph：The symptoms such as oedema are wholly absent with sign；Continuous 3 urine protein examination feminine genders after treatment, or 24h Urine proteins Quantitative continuous are less than 0.1g, and urine erythrocyte disappears under high power lens, and arena counts normal, serum

Albumin returns to more than 35g/L, and serum total cholesterol, triglyceride are normal, normal renal function.

It is basic to alleviate：The symptoms such as oedema disappear substantially with sign；Continuous 3 urine protein examinations reduce 1~2 after treatment "+", last Urine proteins only have 1 "+" or 24h quantity of proteinuria to be continued between 0.1~0.5g, seralbumin 30~ Between 35g/L, serum total cholesterol, triglyceride are close normal, normal renal function or normal.

Effectively：The symptoms such as oedema are clearly better with sign；After treatment continuous three urine protein examinations reduce 1 "+" or 24h quantity of proteinuria is lasting between 0.5~2g, phase before serum total cholesterol, triglyceride and treatment

Than making moderate progress, normal renal function.

It is invalid：The symptoms such as oedema and sign are without being clearly better；24h quantity of proteinuria is more than 2g, serum total cholesterol, glycerine Three fat, renal function are without being clearly better.

4 treatment methods

Control group：Prednisone presses body weight 1mg/kg, early morning 1 administration after the meal.Symptomatic treatment：The obvious person of oedema gives double hydrogen gram urine Thiophene 25mg, bid, antisterone 20mg, bid；Anticoagulant therapy：Persantine 50mg tid.Reducing blood lipid is treated：Blood fat recovery capsule 2, bid（Morning and evening aftermeals）.Prednisone head beginning dose maintenance medications 8 weeks, responder（There is diuresis, 2 weeks within 1 week or so after medication Left and right Urine proteins are significantly reduced, or even

Disappear）Gradually decrement, subtracts 10% in every 2 weeks, and a clothes, continues to minimize effective dose the next day being changed to when reducing to daily 15mg, ties up Hold 6 months, then slow withdrawal observation.2 months nonresponders of medication, are designated as Ineffective Cases, use other Regimen Chemotherapies instead.Effective case Observation period is limited to 1 year.

Treatment group：From the medicine of prescription of the present invention：Radix Codonopsis 30g, Radix Astragali 30g, bighead atractylodes rhizome 30g, Poria cocos 30g, rhizoma alismatis 15g, Rde bean 30g, umbellate pore furgus 15g, corn stigma 30g, cooked aconite 15g, charred RADIX ET RHIZOMA RHEI 15g, charred POLLEN TYPHAE 15g, rhizoma zingiberis 15g, Morinda officinalis 15g, Barrenwort 25g, Psoralea corylifolia 15g.The raw material components of above correspondence group are weighed, is added water to cook according to the routine fashion of decoction of medicinal ingredients, be cooked into Decoction is taken.One one, and half an hour takes after meal sooner or later in two times.It is within 30 days 1 course for the treatment of.

5 observation indexs

Security is observed：（1）General physical examination project；（2）Blood, urine, stool routine examination laboratory examination；（3）The heart, Liver and kidney function inspection；（4）Blood sugar is checked.（5）Blood electrolyte is determined；Health giving quality is observed：（1）Symptom（2）Sign（3）Urine routine test and arena Check；（4）24h quantity of proteinuria；（5）Kidney function test；（6）Blood sedimentation；（7）Total plasma protein, albumin quantitative check；（8）Blood fat（Cholesterol, triglyceride）.

6 statistical methods

Statistical procedures carry out statistical analysis using the statistical analysis softwares of SPSS 17.0, and measurement data is usedtInspection, counts money Material is usedx2 inspections,P<0.05 expression difference has statistical significance.

7 treatment results

Two groups of patient clinical comparitive studies, are shown in Table 1.

1 two groups of patient clinical comparitive studies of table [n (%)]

Group（Number of cases）	Complete incidence graph	It is basic to alleviate	Effectively	It is invalid	It is efficient
						Treatment group（30）	12（40.0%）	14（46.7%）	3（10.0%）	1（10.0%）	96.6%
Control group（20）	6（30.0%）	4（20.0%）	7（35.0%）	3（15.0%）	85.0%

Note：P=0.032 ＜ 0.05, from curative effect, two groups have detailed difference.

Claims

1. a kind of Chinese medicine composition for treating spleen kidney qi deficiency of yang type primary nephrotic syndrome, it is characterised in that by following weight The material medicine composition of proportioning：Radix Codonopsis 20-40 parts, Radix Astragali 20-40 parts, bighead atractylodes rhizome 20-40 parts, Poria cocos 20-40 parts, rhizoma alismatis 10-20 Part, rde bean 20-40 parts, umbellate pore furgus 10-20 parts, corn stigma 20-40 parts, cooked aconite 10-20 parts, charred RADIX ET RHIZOMA RHEI 10-20 parts, charred POLLEN TYPHAE 10-20 parts, rhizoma zingiberis 10-20 parts, Morinda officinalis 10-20 parts, barrenwort 20-30 parts, Psoralea corylifolia 10-20 parts, dried orange peel 10-20 parts, lotus It is sub- 10-20 parts, Gorgon fruit 10-20 parts.

2. Chinese medicine composition as claimed in claim 1, it is characterised in that：It is made up of the material medicine of following weight proportion：Party It is 30 parts of ginseng, 30 parts of the Radix Astragali, 30 parts of the bighead atractylodes rhizome, 30 parts of Poria cocos, 15 parts of rhizoma alismatis, 30 parts of rde bean, 15 parts of umbellate pore furgus, 30 parts of corn stigma, ripe 15 parts of monkshood, 15 parts of charred RADIX ET RHIZOMA RHEI, 15 parts of charred POLLEN TYPHAE, 15 parts of rhizoma zingiberis, 15 parts of Morinda officinalis, 25 parts of barrenwort, 15 parts of Psoralea corylifolia, dried orange peel 15 parts, 15 parts of lotus seeds, 15 parts of Gorgon fruit.