CN105145581B - A kind of the preventing and treating Trichodina that purifies water, the aquatic product fishing medicine of Dactylogyrus and its application - Google Patents
A kind of the preventing and treating Trichodina that purifies water, the aquatic product fishing medicine of Dactylogyrus and its application Download PDFInfo
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- CN105145581B CN105145581B CN201510646552.4A CN201510646552A CN105145581B CN 105145581 B CN105145581 B CN 105145581B CN 201510646552 A CN201510646552 A CN 201510646552A CN 105145581 B CN105145581 B CN 105145581B
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- trichodina
- fishing medicine
- water
- dactylogyrus
- sulfate
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
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Abstract
The present invention relates to a kind of aquatic product fishing medicine for purifying water, preventing and treating Trichodina, preventing and treating Dactylogyrus, described fishing medicine includes copper naphthenate, sodium chloride, NPE, polyoxyethylene 20 sorbitan monooleate, lauryl sodium sulfate, nonylphenol polyoxyethylene ether sulfate, azone, Cupric sulfate, dimehypo, methanol, water.The present invention also provides the preparation method and application of the fishing medicine.Its advantage is shown：The fishing medicine of the present invention can safely and efficiently purify water, prevent and treat Trichodina, preventing and treating Dactylogyrus.
Description
Technical field
The present invention relates to technical field of pharmaceuticals, is a kind of water for purifying water, preventing and treating Trichodina, Dactylogyrus specifically
Produce class fishing medicine and its application.
Background technology
China is culture fishery big country, aquatic livestock parasitic disease be influence culture fishery economic benefit it is important because
Element, wherein, the larger aquatic livestock parasite of harmfulness has Trichodina, Dactylogyrus etc..
Cultivation water constantly deteriorates, in recent years trichodinasis frequency of disease development more and more higher, is caused to fish production very big
Threaten.The characteristics of trichodinasis is presented is that morbidity is early, and the oncoming force is violent；Often have, kill without cease；Scope is wide, and harm is big；It is popular
With endanger a kind of larger fish disease, throughout fish farming area in all parts of the country, particularly Guangdong, Guangxi, Jiangsu, Shanghai, Zhejiang, Hubei and
The ground such as Hunan, make fish production much be lost every year.It is more for the protective agents species of trichodinasis on the market at present,
Also it is very numerous and diverse.Trichodinasis over the course for the treatment of easily repeatedly, the problems such as incidence of disease is high, insecticidal materials using effect unobvious, together
When using during these medicines, there is also many problems.For example alepidote class is more sensitive to Mannich base spermin, generation
Gloomy ammonium, phoxim etc. are easily caused fry and are obtained lopsided from the insecticide that Agrochemicals come using excessive, or even high-volume is dead.Car
Wheel animalcule generates very high resistance to the medicine of in the market, and finding a kind of safe and efficient medicine for killing Trichodina is highly desirable.
Doctylogyrosis is always one of most common disease in aquaculture, and main parasitic is in fish cheek, a large amount of parasitisms
Easily cause fish fry dead, cause economic loss.People's medicine, veterinary drug, agricultural chemicals etc. can be used to be prevented and treated, such as：Formalin,
Mebendazole, chrysanthemum esters, praziquantel.But many medicines have been prohibited from using now because remaining and polluting environment, also have
Medicine causes that parasite generates drug resistance and drug effect reduces due to long-term use, or even invalid.Therefore, Dactylogyrus is prevented and treated
The research of medicine is also extremely important.
Chinese patent literature CN1310592C etc. discloses plant extracts and is used to prevent and treat Trichodina, Dactylogyrus, and China is specially
Sharp document CN101711528B etc. discloses Chinese medicine composition and is used to prevent and treat Trichodina, Dactylogyrus, Chinese patent literature
CN100562253C etc. discloses chemicals and is used to prevent and treat Trichodina, Dactylogyrus.But purifying water, prevent on the present invention
Control Trichodina, the aquatic product fishing medicine of Dactylogyrus and its application and yet there are no report.
The content of the invention
The purpose of the present invention is to be directed to deficiency of the prior art, there is provided one kind, which purifies water, prevents and treats Trichodina, Dactylogyrus
Aquatic product fishing medicine.
Another purpose of the present invention is to provide a kind of preventing and treating Trichodina, aquatic product fishing medicine of Dactylogyrus of purifying water
Preparation method.
Another purpose of the present invention is to provide a kind of preventing and treating Trichodina, aquatic product fishing medicine of Dactylogyrus of purifying water
Using.
To achieve the above object, the present invention adopts the technical scheme that：A kind of fishing medicine, described fishing medicine include aphthenic acids
Copper, azone, Cupric sulfate, dimehypo and surfactant.
The dosage of Cupric sulfate is the 14-17% of gross mass, and the dosage of dimehypo is the 31-36% of gross mass, copper naphthenate
For the 0.5-1.5% of gross mass, azone is the 0.5-1.0% of gross mass.
Described fishing medicine is made by the composition of following percentage by weight：Copper naphthenate 0.5-1.5%, sodium chloride 5.0-
7.0%, NPE 1.0-1.5%, polyoxyethylene 20 sorbitan monooleate 0.5-1.0%, dodecyl
Sodium sulphate 0.3-0.5%, nonylphenol polyoxyethylene ether sulfate 0.1-0.2%, azone 0.5-1.0%, Cupric sulfate 14.0-
17.0%, dimehypo 31.0-36.0%, methanol 2.0-2.5%, water 31.8-45.1%.
Described fishing medicine is made by the composition of following percentage by weight：Copper naphthenate 0.8-1.2%, sodium chloride 5.5-
6.5%, NPE 1.0-1.5%, polyoxyethylene 20 sorbitan monooleate 0.6-1.0%, dodecyl
Sodium sulphate 0.3-0.5%, nonylphenol polyoxyethylene ether sulfate 0.1-0.2%, azone 0.5-0.8%, Cupric sulfate 15.0-
15.5%, dimehypo 33.0-34.0%, methanol 2.0-2.5%, water 36.3-41.2%.
Described fishing medicine is made by the composition of following percentage by weight：Copper naphthenate 1.0%, sodium chloride 6.0%, nonyl phenol
APEO 1.25%, polyoxyethylene 20 sorbitan monooleate 0.8%, lauryl sodium sulfate 0.4%, nonyl phenol gathers
Oxygen ethene ether sodium sulfate 0.15%, azone 0.65%, Cupric sulfate 15.25%, dimehypo 33.5%, methanol 2.25%, water
38.75%.
To realize above-mentioned second purpose, the present invention adopts the technical scheme that：Described preparation method includes following step
Suddenly：1) Cupric sulfate, dimehypo, sodium chloride is soluble in water, 2) copper naphthenate, NPE, polyoxyethylene sorbitan
Sorbitol monooleate, lauryl sodium sulfate, nonylphenol polyoxyethylene ether sulfate, azone, methanol mixing, 3) by the
The solution mixing that 1 step and the 2nd step obtain.
To realize above-mentioned 3rd purpose, the present invention adopts the technical scheme that：Described fishing medicine is purifying water, prevented and treated
Purposes in Trichodina or preventing and treating Dactylogyrus.
The invention has the advantages that：
The present invention provides a kind of new aquatic product fishing medicine for purifying water, prevent and treat Trichodina, preventing and treating Dactylogyrus, this fishing medicine
It is safe and efficient.
Embodiment
Embodiment provided by the invention is elaborated with reference to embodiment.
The Novel fishing medicine of the present invention is made by the composition of following percentage by weight：Copper naphthenate 0.5-1.5%, sodium chloride
5.0-7.0%, NPE 1.0-1.5%, polyoxyethylene 20 sorbitan monooleate 0.5-1.0%, 12
Sodium alkyl sulfate 0.3-0.5%, nonylphenol polyoxyethylene ether sulfate 0.1-0.2%, azone 0.5-1.0%, Cupric sulfate
14.0-17.0%, dimehypo 31.0-36.0%, methanol 2.0-2.5%, water 31.8-45.1%.
Preferably, copper naphthenate 0.8-1.2%, sodium chloride 5.5-6.5%, NPE 1.0-1.5%, gather
Oxygen ethene sorbitan monooleate 0.6-1.0%, lauryl sodium sulfate 0.3-0.5%, NPE sulphur
Sour sodium 0.1-0.2%, azone 0.5-0.8%, Cupric sulfate 15.0-15.5%, dimehypo 33.0-34.0%, methanol 2.0-
2.5%, water 36.3-41.2%.
The Novel fishing medicine of embodiment 1
It is 1) Cupric sulfate, dimehypo, sodium chloride is soluble in water,
2) copper naphthenate, NPE, polyoxyethylene 20 sorbitan monooleate, dodecyl sulphate
Sodium, nonylphenol polyoxyethylene ether sulfate, azone, methanol mixing,
3) solution for obtaining the 1st step and the 2nd step mixes.
The Novel fishing medicine of embodiment 2
It is 1) Cupric sulfate, dimehypo, sodium chloride is soluble in water,
2) copper naphthenate, NPE, polyoxyethylene 20 sorbitan monooleate, dodecyl sulphate
Sodium, nonylphenol polyoxyethylene ether sulfate, azone, methanol mixing,
3) solution for obtaining the 1st step and the 2nd step mixes.
The Novel fishing medicine of embodiment 3
It is 1) Cupric sulfate, dimehypo, sodium chloride is soluble in water,
2) copper naphthenate, NPE, polyoxyethylene 20 sorbitan monooleate, dodecyl sulphate
Sodium, nonylphenol polyoxyethylene ether sulfate, azone, methanol mixing,
3) solution for obtaining the 1st step and the 2nd step mixes.
The Novel fishing medicine of embodiment 4
It is 1) Cupric sulfate, dimehypo, sodium chloride is soluble in water,
2) copper naphthenate, NPE, polyoxyethylene 20 sorbitan monooleate, dodecyl sulphate
Sodium, nonylphenol polyoxyethylene ether sulfate, azone, methanol mixing,
3) solution for obtaining the 1st step and the 2nd step mixes.
The Novel fishing medicine of embodiment 5
It is 1) Cupric sulfate, dimehypo, sodium chloride is soluble in water,
2) copper naphthenate, NPE, polyoxyethylene 20 sorbitan monooleate, dodecyl sulphate
Sodium, nonylphenol polyoxyethylene ether sulfate, azone, methanol mixing,
3) solution for obtaining the 1st step and the 2nd step mixes.
The Trichodina effect experiment of embodiment 6
First, experimental principle
Take the class insecticidal materials of in the market two i.e. wheel finger ring net and the legendary god of farming 168 carries out drug effect contrasts with this product.Take this three kinds
Medicine dilutes 4 concentration gradients respectively to be tested.With the method for microscopy, the so ill live body gill filament and mucus observation is derived from,
The Trichodina of more than 5 is seen under one visual field, so that it may conclude there is trichodinasis, the gill portion meeting parasitism of general very sick has 25
Individual or so Trichodina.To ill fish body with certain density medicine, pass through the quantity and table body of Trichodina under viewing microscope
Symptom, the state survived, situation is ingested to judge the drug effect of medicine.By understand the mechanism of action of medicine and the position of effect come
Block damage of the Trichodina to body.Wheel finger ring is combined by the acetylcholinesterase with polypide only, suppresses acetylcholine ester
Enzymatic activity, cause its nervous function not normal, so as to reach the purpose of desinsection.And this product is to enter polypide by osmosis to reach
To killing effect.
2nd, experiment equipment：
400 the grass carp disease fish for suffering from trichodinasis is black and thin, does not ingest, and is in micro white around the gill and mouth of fish, body surface other
Normally, gill portion mucus is more, and gill filament microscopy can find that a large amount of Trichodinas are parasitic, parasitic quantity in 18~25/tail, polypide compared with
It is small.Light microscope, graduated cylinder, test tube, distilled water, glass bar, box for breeding etc..
3rd, experimental procedure：
By 300 sick 3 parts of fish average marks and be grouped, the fine day morning 9 when or so three kinds of medicines of splashing respectively, while open oxygenation
Machine, keep oxygen sufficient.Splash again every other day the 2nd time, the 4th group is that blank group does not have to splash.Novel fishing medicine (embodiment 1) is first
Group, wheel finger ring are second group only, and the legendary god of farming 168 is third group.The sample for three kinds of medicines that content is 45% is taken to dilute 1000 respectively
Again, 1500 times, 2000 times, 2500 times, numbering is respectively first 1, first 2, first 3, first 4；Second 1, second 2, second 3, second 4；The third 1, the third 2, third
3rd, the third 4.Fully it is watered after dissolving and uniformly splashes into the box for breeding for the treatment of group, ensures that oxygen is sufficient, seen in the case that PH is suitable
The reaction of fish body gill portion Trichodina is examined, checks the Trichodina survival condition in fish body gill portion after 24h by parasitology test method, and
Carry out statistical analysis.
4th, experimental result and analysis
1st, experimental result
Visually observe three groups of illness fish status discoveries after 24h, first group substantially three groups than other growth conditions it is good, microscopy
The quantity of observation each group gill filament position Trichodina can draw following 1 table data：
Table 1
Mark：Gill portion wheel borer population before gill portion wheel borer population/medication after killing rate=medication.
Three kinds of medicines of equivalent are used under the same terms every other day, the quantity of microscopy fish gill portion Trichodina, draws after same 24h
Following 2 table data：
Table 2
Mark：Gill portion wheel borer population before gill portion wheel borer population/medication after killing rate=medication.
Upper table shows the negligible amounts of the gill portion Trichodina in the case of 1000 times of dilution between same group, in extension rate phase
The negligible amounts of the ill fish gill portion Trichodina of first group with the case of.Under certain condition, the quantity of gill portion Trichodina is fewer,
The drug effect of medicine is better.
2nd, experimental analysis
All taken an evident turn for the better with sick fish table body characteristicses before and after three kinds of medicines, serious body surface has one layer of nebula, edge before medication
The mad trip in box for breeding edge, it is in micro white around sick fish head portion and mouth, secretes many mucus etc. and gradually take a turn for the better.If by small fish micro-
Still there is a small amount of Trichodina in Microscopic observation, the gill portion of some ill fishes, so as to contrast the drug effect of three kinds of medicines with this.
First group is better than other two groups as can be seen from Table 1, while can be seen that the effect of first group has in table 2 and significantly carry
Height, and second group and third group do not have significant change.There is certain resistance to the action of a drug to many chemical classes medicines of in the market according to analysis Trichodina,
It is smaller that the net volatility of wheel finger ring is checked in simultaneously, is made into the gradual decomposition failure of meeting after the aqueous solution, but formed under weak basic condition
DDVP, cause poisoning, it is seen that certain risk can be caused to operator using metrifonate.
The Dactylogyrus effect experiment of embodiment 7
First, experimental animal
Host's model is healthy goldfish, and parasite model is the medium-sized Dactylogyrus for parasitizing goldfish cheek, by infection
The goldfish of medium-sized Dactylogyrus is raised together with healthy goldfish, healthy goldfish is infected medium-sized Dactylogyrus, to reach the purpose of live population.
2nd, the measure of Dactylogyrus activity is killed
Contain into abundant aeration underground water, control 25 ± 1 DEG C, pH 7.0-7.5 of water temperature, during on-test, first to infection
The goldfish material of medium-sized Dactylogyrus inspects 10 tails by random samples at random, if goldfish infection rate is 100%, and infects the medium-sized Dactylogyrus of goldfish cheek
Quantity be more than 25 when, infection goldfish can be used to test.According to the present invention Novel fishing medicine set corresponding to test group,
Control group, three repetitions of every group of setting, each tail of infection goldfish 30 for repeating to use.Test the 48th hour and take the full cheek system of goldfish
Piece, microexamination, killing result of the observation each group to medium-sized Dactylogyrus, statistics killing rate, fish death rate etc..
As a result show that the Dactylogyrus killing rate of the Novel fishing medicine of the present invention is higher than 90%.
The safety experiment of embodiment 8
Through the foregoing test of pesticide effectiveness, special safety test, it was demonstrated that Novel fishing medicine of the invention is safe and reliable.
The other parasite effect experiments of embodiment 9
It is also effective to the aquatic livestock such as other protozoon classes, Vermes vermin through experiment, Novel fishing medicine of the invention.
The other Novel fishing medicines of embodiment 10
It is soluble in water by Cupric sulfate, dimehypo, sodium chloride, while copper naphthenate, azone are dissolved in surfactant
In, then both is mixed to the Novel fishing medicine for producing the present embodiment.
Wherein, the dosage of Cupric sulfate is the 14-17% of gross mass, and the dosage of dimehypo is the 31-36% of gross mass, cycloalkanes
Sour copper is the 0.5-1.5% of gross mass, and azone is the 0.5-1.0% of gross mass.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, on the premise of the inventive method is not departed from, can also make some improvement and supplement, and these are improved and supplement also should be regarded as
Protection scope of the present invention.
Claims (2)
- A kind of 1. application of fishing medicine in purifying water, preventing and treating Trichodina or prevent and treat Dactylogyrus, it is characterised in that described fishing medicine It is made by the composition of following percentage by weight：Copper naphthenate 0.8-1.2%, sodium chloride 5.5-6.5%, NPE 1.0-1.5%, polyoxyethylene 20 sorbitan monooleate 0.6-1.0%, lauryl sodium sulfate 0.3-0.5%, nonyl phenol gather Oxygen ethene ether sodium sulfate 0.1-0.2%, azone 0.5-0.8%, Cupric sulfate 15.0-15.5%, dimehypo 33.0- 34.0%, methanol 2.0-2.5%, water 36.3-41.2%；The preparation method of described fishing medicine comprises the following steps：1）By desinsection List, dimehypo, sodium chloride are soluble in water, and 2）Copper naphthenate, NPE, polyoxyethylene sorbitan list oleic acid Ester, lauryl sodium sulfate, nonylphenol polyoxyethylene ether sulfate, azone, methanol mixing, 3）1st step and the 2nd step are obtained The solution mixing arrived.
- 2. application according to claim 1, it is characterised in that described fishing medicine by following percentage by weight composition system ：Copper naphthenate 1.0%, sodium chloride 6.0%, NPE 1.25%, polyoxyethylene sorbitan list oleic acid Ester 0.8%, lauryl sodium sulfate 0.4%, nonylphenol polyoxyethylene ether sulfate 0.15%, azone 0.65%, Cupric sulfate 15.25%, dimehypo 33.5%, methanol 2.25%, water 38.75%.
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| CN201510646552.4A CN105145581B (en) | 2015-10-08 | 2015-10-08 | A kind of the preventing and treating Trichodina that purifies water, the aquatic product fishing medicine of Dactylogyrus and its application |
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| CN201510646552.4A CN105145581B (en) | 2015-10-08 | 2015-10-08 | A kind of the preventing and treating Trichodina that purifies water, the aquatic product fishing medicine of Dactylogyrus and its application |
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| CN105145581A CN105145581A (en) | 2015-12-16 |
| CN105145581B true CN105145581B (en) | 2018-04-06 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1310592C (en) * | 2005-09-13 | 2007-04-18 | 西北大学 | Pollution-less botanical pesticide for fish |
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Inventor after: Dong Yaping Inventor after: Liu Tengfei Inventor after: Wang Ting Inventor after: Hu Kun Inventor after: Zhu Fengjiao Inventor after: Cheng Junming Inventor after: Lv Xinmei Inventor after: Liu Siya Inventor after: Wu Yingjie Inventor after: Liang Nan Inventor after: Xie Xinyan Inventor before: Hu Kun Inventor before: Liu Tengfei Inventor before: Wang Ting Inventor before: Zhu Fengjiao Inventor before: Dong Yaping Inventor before: Cheng Junming Inventor before: Lv Xinmei Inventor before: Liu Siya Inventor before: Wu Yingjie Inventor before: Liang Nan Inventor before: Xie Xinyan |
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Granted publication date: 20180406 Termination date: 20181008 |