CN105213406A - A kind of compositions of preventing and treating Squaliobarbus ourriculus fish molds - Google Patents
A kind of compositions of preventing and treating Squaliobarbus ourriculus fish molds Download PDFInfo
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- CN105213406A CN105213406A CN201510643514.3A CN201510643514A CN105213406A CN 105213406 A CN105213406 A CN 105213406A CN 201510643514 A CN201510643514 A CN 201510643514A CN 105213406 A CN105213406 A CN 105213406A
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- thioether
- salicylic acid
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Abstract
The invention discloses a kind of compositions of preventing and treating Squaliobarbus ourriculus fish molds, comprise the husky star of thioether and salicylic acid, the mass fraction of each component is: thioether husky 1 ~ 5 part, star, salicylic acid 0.2 ~ 1 part; In proportion husky for thioether star and salicylic acid mix and blend are made former medicine, throw in the former dose of 0.15 ~ 0.25g for every cubic metre, be diluted with water to 1000 times and form medicinal liquid; Spill in fishpond by the medicinal liquid prepared, cut off the water supply simultaneously, open oxygen increasing equipment, fresh water of annotating after 15 ~ 45min, added a medicine every one day, continued operation 3 ~ 5 times.The husky star of thioether is with salicylic acid through scientific compatibility, and make the permeability of compositions stronger, bactericidal action is doubled, and the husky star of thioether and salicylic acid remaining in environment and Squaliobarbus ourriculus body is lower, and consumption cost is cheap; Alternative malachite green oxalate uses, and makes every effort to overcome compare the curative effect of fish molds with Chinese traditional herbs and mildew, cure rate and survival rate higher, meet national Aquatic product fisheries drug new standard.
Description
Technical field
The present invention relates to one and relate to technical field of aquaculture, be specifically related to a kind of compositions of preventing and treating Squaliobarbus ourriculus fish molds.
Background technology
Fish molds is the disease caused by fungal infection fish body, and pathogen is Saprolegniaceae, some kinds of Saprolegnia and Achyla, and thalline is without tabula, has the filamentous that branch, multinuclear are transparent, breeds in spore-bearing mode.Water mo(u)ld is extensively present in fresh water or brackish water and slowly drained soil, saprophytic on the Organic substance of death; The generation of fish molds is main because " urgent " Secondary infection of causing, fish only because of crowded, mobile, to transport or other environmental factorss cause body surface organization injured and infect.Initial infection naked eyes do not see symptom, now the spore of wound starts to sprout formation mycelia, and immerse tissue constantly growth, secretory protein catabolic enzyme decomposes host protein, and the nutrient substance absorbing fish body, to outgrowth, forms the cotton-shaped outer mycelia of macroscopic canescence, sick fish is often bubbled through the water column, slowly movable, loss of appetite, dies of exhaustion.According to statistics, Beijing area in recent years Fish fungoid, bacterial disease sickness rate accounts for 65% of annual total incidence, directly causes economic loss more than 2,000 ten thousand yuan.And the active drug of directed toward bacteria property, fungus disease of fish complication is few at present, adopt the chemicalses such as malachite green oxalate to treat for many years both at home and abroad always.Particularly malachite green oxalate, because it is cheap, there is the effects such as sterilization, once the fungus of aquatic animal, the control of bacterial disease was widely used in, but malachite green oxalate is a kind of triphenylmethane industrial dye of synthesis, malachite green oxalate and metabolite leucomalachite green thereof the residence time in fish body and in environment is long, is had the toxic and side effects such as carcinogenic, teratogenesis, mutagenesis by confirmation.Given this, malachite green oxalate was listed in " veterinary drug of food animal forbidding and compound inventory thereof " in May, 2002 by China.Therefore to replace malachite green oxalate to prevent and treat the medicine of aquatic animal disease effects extremely urgent in research.
All can there is fish molds in Squaliobarbus ourriculus the whole year, therefore, if do not prevented and not treated Squaliobarbus ourriculus fish molds, the loss brought to raiser is inestimable.In prior art, Squaliobarbus ourriculus has infected water mo(u)ld, general uses Chinese traditional herbs treatment, and survival rate is only 20% ~ 30%, although and mildew is in the market made every effort to overcome and is had certain curative effect to mycosis, but not ideal.
Therefore, need badly and work out a kind of new medicine, the medicine solving prior art Malachite Green is disabled, and Chinese traditional herbs and mildew are made every effort to overcome the less-than-ideal difficult problem of the curative effect of fish molds.
Summary of the invention
The invention is intended to provide a kind of compositions of preventing and treating Squaliobarbus ourriculus fish molds, disabled to solve prior art Malachite Green, and the Chinese traditional herbs substituted and mildew are made every effort to overcome the less-than-ideal present situation of the curative effect of fish molds.
A kind of compositions of preventing and treating Squaliobarbus ourriculus fish molds in this programme, comprise the husky star of thioether and salicylic acid, the mass fraction of each component is: thioether husky 1 ~ 5 part, star, salicylic acid 0.2 ~ 1 part.
Operation principle of the present invention and beneficial effect:
Separation and Extraction is out from garlicin for the husky star of thioether, ideal substitute as malachite green oxalate uses, have that cost is low, effective, use safety, convenience, noresidue feature, original killing action is had to the fungus causing fish body fish molds, have good killing action to Aeromonas hydrophila, Vibrio anguillarum, Edwardsiella tarda and Cytophaga Columnaris, the dermatosis for the treatment of Squaliobarbus ourriculus has specially good effect simultaneously.The husky star of thioether has extremely strong permeability, can kill water body cause of disease, can penetrate in animal cuticle again and kill pathogen, and can stimulate reepithelialization, has functions such as promoting skin tissue recovering.
Salicylic acid has another name called salicylic acid, and chemical name is " oxybenzoic acid ", is the ring type structure thing containing carbolic acid ring.Be present in natural bark of willow, Gaultheria leaf and sweet birch tree.In medical, salicylic acid has antifungal, antipruritic and dissolving cutin effect.When fish body surface fungal infection, salicylic acid can soften cuticle, and when horny layer comes off, also come off by mycelia, in addition, salicylic acid can help penetrating of other antifungal drugs simultaneously, and bacteria growing inhibiting.
The present inventor is through consulting a large amount of fish disease prevention and cure measures and various fisheries drug pharmacology data thereof, and multiple fisheries drug is carried out proportioning, and repetition test finally draws formula of the present invention; Husky for thioether star and salicylic acid are carried out scientific compatibility, and make the permeability of compositions stronger, bactericidal action is doubled, and compared to being used alone thioether husky star treatment Squaliobarbus ourriculus fish molds, treatment time is short, and cure rate brings up to more than 80% from 50%; Make salicylic toxic and side effects reduce, the husky star of thioether and salicylic acid remaining in environment and Squaliobarbus ourriculus body is lower, and consumption cost is cheap simultaneously; Alternative malachite green oxalate uses, and makes every effort to overcome compare the curative effect of fish molds with Chinese traditional herbs and mildew, cure rate and survival rate higher, meet national Aquatic product fisheries drug new standard.
Further, the mass fraction of the husky star of described thioether is 5, and salicylic acid mass fraction is 1.This number is optimal proportion, best to the action effect of Squaliobarbus ourriculus fish molds, and cure rate can reach 95%.
Further, in proportion husky for thioether star and salicylic acid mix and blend are made former medicine, throw in the former dose of 0.15 ~ 0.25g for every cubic metre, be diluted with water to 1000 times and form medicinal liquid.If directly shed without dilution, avoid local concentration excessive, excessive to the injury of part fish body after shedding; Or local concentration is too small, and can not play the effect of sterilization to fish body, this concentration is arranged rationally, is convenient to the incremental of bactericidal effect, and the therapeutic effect for Squaliobarbus ourriculus fish molds is more remarkable.
Further, spill in fishpond, cut off the water supply the medicinal liquid prepared simultaneously, open oxygen increasing equipment, fresh water of annotating after 15 ~ 45min, added a medicine every one day, continued operation 3 ~ 5 times.Cooperatively interacted by the number of times of the concentration of compositions, dosing duration, operation, obtain optimum curative effect; This medical instrument has effect of sterilization, antiinflammatory, convergence wound, simple to operate, continues feeding after medication, the Squaliobarbus ourriculus wound healing normal growth of 80%-95% after three days.
Further, the time controling of dosing is between 9:00 ~ 12:00 or 17:00 ~ 19:00.Between 19:00 to the 9:00 of rainy weather or fine day, the oxygen concentration now in fishpond is that whole day is minimum, and medicine of splashing can consume a large amount of dissolved oxygens, makes the oxygen concentration in fishpond lower, very easily causes aquatic animal anoxia to raise the nose above water to breathe, even general pond; And 12:00 ~ 17:00, ambient temperature is the highest, and the toxicity of Medicines in Aquaculture generally strengthens with the rising of temperature, therefore will avoid this period.
Detailed description of the invention
Get 12 fishponds as experiment contrast, be assigned randomly in 12 fishponds by the Squaliobarbus ourriculus infecting fish molds, the Squaliobarbus ourriculus quantity in each fishpond is 100, and data and the experiment effect of specific experiment are as shown in table 1 below:
Table 1:
Illustrate for wherein several experimental group:
Embodiment 1:
In the 10:00 dispenser that bright day gas Environment temperature is slightly low, the electronic balance that high accuracy Germany sartorius imported with original packaging model is TP-A600 is used to weigh compositions, by husky for thioether star according to 0.125g/m
3with salicylic acid according to 0.025g/m
3preparation mix and blend makes former medicine, the standard of the former dose of 0.15g is thrown in every cubic metre, be diluted with water to 1000 times and form medicinal liquid, the medicinal liquid prepared is spilled in fishpond, block into water simultaneously, close water outlet, open Rhea machinery, model is RY-PS-1.5, and specification is that the aerator of 1.5KW, 220V is to supplemental oxygen in fishpond; To annotate after 30min fresh water, open water outlet simultaneously, added a medicine every one day, continued operation 3 times; Continue feeding after medication, after three days 95% Squaliobarbus ourriculus wound healing normal growth, the survival rate 90% of Squaliobarbus ourriculus.
Embodiment 2
In the 10:00 dispenser that bright day gas Environment temperature is slightly low, the electronic balance that high accuracy Germany sartorius imported with original packaging model is TP-A600 is used to weigh compositions, by husky for thioether star according to 0.12g/m
3with salicylic acid according to 0.03g/m
3preparation mix and blend makes former medicine, the standard of the former dose of 0.15g is thrown in every cubic metre, be diluted with water to 1000 times and form medicinal liquid, the medicinal liquid prepared is spilled in fishpond, block into water simultaneously, close water outlet, open Rhea machinery, model is RY-PS-1.5, and specification is that the aerator of 1.5KW, 220V is to supplemental oxygen in fishpond; To annotate after 30min fresh water, open water outlet simultaneously, added a medicine every one day, continued operation 3 times; Continue feeding after medication, after three days 85% Squaliobarbus ourriculus wound healing normal growth, the survival rate 85% of Squaliobarbus ourriculus.
Embodiment 3:
In the 10:00 dispenser that bright day gas Environment temperature is slightly low, the electronic balance that high accuracy Germany sartorius imported with original packaging model is TP-A600 is used to weigh compositions, by husky for thioether star according to 0.11g/m
3with salicylic acid according to 0.04g/m
3preparation mix and blend makes former medicine, the standard of the former dose of 0.15g is thrown in every cubic metre, be diluted with water to 1000 times and form medicinal liquid, the medicinal liquid prepared is spilled in fishpond, block into water simultaneously, close water outlet, open Rhea machinery, model is RY-PS-1.5, and specification is that the aerator of 1.5KW, 220V is to supplemental oxygen in fishpond; To annotate after 40min fresh water, open water outlet and added a medicine every one day, continued operation 5 times; Continue feeding after medication, after three days 80% Squaliobarbus ourriculus wound healing normal growth, the survival rate 75% of Squaliobarbus ourriculus.
Embodiment 4:
In the 10:00 dispenser that bright day gas Environment temperature is slightly low, the electronic balance that high accuracy Germany sartorius imported with original packaging model is TP-A600 is used to weigh compositions, by husky for thioether star according to 0.1g/m
3with salicylic acid according to 0.05g/m
3preparation mix and blend makes former medicine, the standard of the former dose of 0.15g is thrown in every cubic metre, be diluted with water to 1000 times and form medicinal liquid, the medicinal liquid prepared is spilled in fishpond, block into water simultaneously, close water outlet, open Rhea machinery, model is RY-PS-1.5, and specification is that the aerator of 1.5KW, 220V is to supplemental oxygen in fishpond; To annotate after 40min fresh water, open water outlet and added a medicine every one day, continued operation 5 times; Continue feeding after medication, after three days 70% Squaliobarbus ourriculus wound healing normal growth, the survival rate 70% of Squaliobarbus ourriculus.
Embodiment 5:
In the 10:00 dispenser that bright day gas Environment temperature is slightly low, the electronic balance that high accuracy Germany sartorius imported with original packaging model is TP-A600 is used to weigh compositions, by husky for thioether star according to 0.075g/m
3with salicylic acid according to 0.075g/m
3preparation mix and blend makes former medicine, the standard of the former dose of 0.15g is thrown in every cubic metre, be diluted with water to 1000 times and form medicinal liquid, the medicinal liquid prepared is spilled in fishpond, block into water simultaneously, close water outlet, open Rhea machinery, model is RY-PS-1.5, and specification is that the aerator of 1.5KW, 220V is to supplemental oxygen in fishpond; To annotate after 40min fresh water, open water outlet and added a medicine every one day, continued operation 5 times; Continue feeding after medication, after three days 60% Squaliobarbus ourriculus wound healing normal growth, the survival rate 50% of Squaliobarbus ourriculus.
Embodiment 6:
In the 10:00 dispenser that bright day gas Environment temperature is slightly low, the electronic balance that high accuracy Germany sartorius imported with original packaging model is TP-A600 is used to weigh compositions, by husky for thioether star according to 0.16g/m
3with salicylic acid according to 0.04g/m
3preparation mix and blend makes former medicine, the standard of the former dose of 0.2g is thrown in every cubic metre, be diluted with water to 1000 times and form medicinal liquid, the medicinal liquid prepared is spilled in fishpond, block into water simultaneously, close water outlet, open Rhea machinery, model is RY-PS-1.5, and specification is that the aerator of 1.5KW, 220V is to supplemental oxygen in fishpond; To annotate after 20min fresh water, open water outlet and added a medicine every one day, continued operation 3 times; Continue feeding after medication, after three days 85% Squaliobarbus ourriculus wound healing normal growth, the survival rate 85% of Squaliobarbus ourriculus.
Embodiment 7:
In the 10:00 dispenser that bright day gas Environment temperature is slightly low, the electronic balance that high accuracy Germany sartorius imported with original packaging model is TP-A600 is used to weigh compositions, by husky for thioether star according to 0.2g/m
3with salicylic acid according to 0.05g/m
3preparation mix and blend makes former medicine, the standard of the former dose of 0.25g is thrown in every cubic metre, be diluted with water to 1000 times and form medicinal liquid, the medicinal liquid prepared is spilled in fishpond, block into water simultaneously, close water outlet, open Rhea machinery, model is RY-PS-1.5, and specification is that the aerator of 1.5KW, 220V is to supplemental oxygen in fishpond; To annotate after 20min fresh water, open water outlet and added a medicine every one day, continued operation 3 times; Continue feeding after medication, after three days 80% Squaliobarbus ourriculus wound healing normal growth, the survival rate 80% of Squaliobarbus ourriculus.
The present inventor is through consulting a large amount of fish disease prevention and cure measures and various fisheries drug pharmacology data thereof, and multiple fisheries drug is carried out proportioning, and repetition test finally draws formula of the present invention; Husky for thioether star and salicylic acid are carried out scientific compatibility, and make the permeability of compositions stronger, bactericidal action is doubled, and compared to being used alone thioether husky star treatment Squaliobarbus ourriculus fish molds, treatment time is short, and cure rate brings up to more than 80% from 50%; Make salicylic toxic and side effects reduce, the husky star of thioether and salicylic acid remaining in environment and Squaliobarbus ourriculus body is lower, and consumption cost is cheap simultaneously; Alternative malachite green oxalate uses, and makes every effort to overcome compare the curative effect of fish molds with Chinese traditional herbs and mildew, cure rate and survival rate higher, meet national Aquatic product fisheries drug new standard.
Above-described is only embodiments of the invention, and in scheme, known characteristic general knowledge does not do too much description at this.Should be understood that; for a person skilled in the art, under the prerequisite not departing from structure of the present invention, some distortion and improvement can also be made; these also should be considered as protection scope of the present invention, and these all can not affect effect of the invention process and practical applicability.The protection domain that this application claims should be as the criterion with the content of its claim, and the detailed description of the invention in description etc. record the content that may be used for explaining claim.
Claims (5)
1. prevent and treat a Squaliobarbus ourriculus fish molds compositions, it is characterized in that, comprise the husky star of thioether and salicylic acid, the mass fraction of each component is: thioether husky 1 ~ 5 part, star, salicylic acid 0.2 ~ 1 part.
2. one control Squaliobarbus ourriculus fish molds compositions according to claim 1, is characterized in that: the mass fraction of the husky star of described thioether is 5, and salicylic acid mass fraction is 1.
3. the manufacture method of the control Squaliobarbus ourriculus fish molds compositions as described in claim 1 ~ 2, it is characterized in that: in proportion husky for thioether star and salicylic acid mix and blend are made former medicine, every cubic metre of fishpond, by the former dose of 0.15 ~ 0.25g, is diluted with water to 1000 times and forms medicinal liquid.
4. a using method for method preparation control Squaliobarbus ourriculus fish molds compositions as claimed in claim 3, is characterized in that: be spilled in fishpond by the medicinal liquid prepared, cut off the water supply simultaneously, open oxygen increasing equipment, to annotate after 15 ~ 45min fresh water, added a medicine every one day, continued operation 3 ~ 5 times.
5. the using method of control Squaliobarbus ourriculus fish molds compositions according to claim 4, is characterized in that: the time controling of dosing is between 9:00 ~ 12:00 or 17:00 ~ 19:00.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107307232A (en) * | 2017-07-20 | 2017-11-03 | 通化师范学院 | It is a kind of to prevent and treat Chinese herbal feed additive of saprolegniasis and application thereof in trout breeding process |
| CN107412322A (en) * | 2017-08-22 | 2017-12-01 | 中国水产科学研究院珠江水产研究所 | It is a kind of to be used to prevent and treat composition of aquaculture saprolegniasis and preparation method thereof |
| CN112587557A (en) * | 2020-12-29 | 2021-04-02 | 西藏自治区农牧科学院水产科学研究所 | Preparation for preventing and treating saprolegniasis of Tibet plateau fishes |
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| CN102920715A (en) * | 2012-10-29 | 2013-02-13 | 上海海洋大学 | Compound dry powder for preventing and treating saprolegniasis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102920715A (en) * | 2012-10-29 | 2013-02-13 | 上海海洋大学 | Compound dry powder for preventing and treating saprolegniasis and preparation method thereof |
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| 李大霞: "大蒜素治鱼病的好方法", 《中国渔业报》 * |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107307232A (en) * | 2017-07-20 | 2017-11-03 | 通化师范学院 | It is a kind of to prevent and treat Chinese herbal feed additive of saprolegniasis and application thereof in trout breeding process |
| CN107412322A (en) * | 2017-08-22 | 2017-12-01 | 中国水产科学研究院珠江水产研究所 | It is a kind of to be used to prevent and treat composition of aquaculture saprolegniasis and preparation method thereof |
| CN112587557A (en) * | 2020-12-29 | 2021-04-02 | 西藏自治区农牧科学院水产科学研究所 | Preparation for preventing and treating saprolegniasis of Tibet plateau fishes |
| CN112587557B (en) * | 2020-12-29 | 2022-04-19 | 西藏自治区农牧科学院水产科学研究所 | Preparation for preventing and treating saprolegniasis of rassa schizopygma nojirima |
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Application publication date: 20160106 |