CN105126159A - Biomedical polysaccharide colloidal solution and preparation method thereof - Google Patents
Biomedical polysaccharide colloidal solution and preparation method thereof Download PDFInfo
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- CN105126159A CN105126159A CN201510577511.4A CN201510577511A CN105126159A CN 105126159 A CN105126159 A CN 105126159A CN 201510577511 A CN201510577511 A CN 201510577511A CN 105126159 A CN105126159 A CN 105126159A
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Abstract
The invention discloses a biomedical polysaccharide colloidal solution. The biomedical polysaccharide colloidal solution comprises, by weight, 0.2-5% of low-viscosity sodium carboxymethylcellulose, 0.2-4% of medium-viscosity sodium carboxymethylcellulose, 0.2-2% of high-viscosity sodium carboxymethylcellulose, 0.5-1.5% of sodium chloride and the balance injection water. The biomedical polysaccharide colloidal solution has the advantages that through formula optimization, viscosity is moderate, easiness in washing is achieved, a reliable, uniform and soft protective film is formed on the surface of a wound, and a wet environment for the surface of the wound is formed; when the biomedical polysaccharide colloidal solution is used for cell repair, scar formation can be inhibited directly, the protective film can be formed on the surface of the wound to stop bacteria attack on the surface of the wound, and processes such as adsorption, proliferation and duplication of bacteria on the surface of the wound are inhibited; the biomedical polysaccharide colloidal solution is free of toxic and side effects, has high clinical application value and is short in healing time and high in healing rate.
Description
Technical field
The present invention relates to a kind of polysaccharide bio-medical colloidal solution.
Background technology
Since century more than one, dressing flap coverage is mainly applied in the process of western medicine to wound surface (skin), Wound dressing can prevent from microbial contamination wound surface and can protect from infection propagating to other patients theoretically, and in clinical practice, dressing also mainly plays a kind of barrier action.Furthermore, the composition of dressing and characteristic itself can play the effect of regulation and control local wound microenvironment.The sixties forward position Wound dressing of over half a century, be gauze mostly, gauze is many by Cotton Gossypii, lint and linen process, and belong to inertia dressing, and its designing axiom is all absorb, get rid of the effect of wound exudate and wound surface isolation, to the healing of wound surface without obvious facilitation.To dressing material Quality Research also mainly from biologically inert, the aspect such as avirulence and biocompatibility is considered, but the environment that the dressing of this structure causes wound surface drier, wound surface is dewatered. cause incrustation, and the epithelization of the incrustation of wound surface to wound surface has obvious obstacle, its shortcoming is also very outstanding, and such as: wound surface (1) cannot be kept moistening, wound healing postpones; (2) dressing fiber easily comes off, and causes foreign body reaction, impact healing; (3) wound granulation is organized and is easily grown in the mesh of dressing, can cause pain when changing dressings; (4), when dressing is soaked into, pathogen is easily passed through; (5) when changing dressings, the tissue of easy damaged new life; (6) workload of changing dressings is large.
The moist environment healing theory mechanism of action: (1) has stronger autolytic debridement ability, optionally removes slough, absorbs a large amount of transudates and noxious substance.(2) maintain suitable partial pressure of oxygen, promote the formation of blood vessel and granulation tissue.(3) maintain the suitable humidity of wound surface, promote wound healing.(4) moistening wound surface can maintain edge of wound to the normal potential gradient of wound surface central authorities, and promote that more somatomedin combines, this is by wound healing.(5) wound surface can alleviate tissue dewatering under wet environment, cell death, and accelerate revascularization and ease the pain, strengthen various somatomedin to wound repair, moist environment can accelerate epidermis cell migration velocity.(6) micro-acid environment energy bacteria growing inhibiting, bearing hydrocolloid dressing provides airtight moist environment, fibroblastic synthesis can not only be promoted and stimulate blood vessel hyperplasia, the intrusion of extraneous antibacterial can be completely cut off simultaneously, thus shorten the time of wound healing, reduce infection rate, alleviate the misery of patient.Research finds, under incrustation forces the migration pile warp crust of epidermis cell, hinders the migration of epidermis cell, extend healing time, and moist environment can increase the migration velocity of epidermis cell.Under moist environment, the healing of wound surface is also in recent years by new concept that scholars accept.Moist environment can make leukocyte function strengthen.
The level of consumption of China in treatment of wounds and same kind of products at abroad price differ greatly, drop into lower in technical research, product advantage is also not obvious, such as effect is not obvious, kind is single, do not form series of products, more the market segments are not carried out to target customer, be therefore far from meeting the vigorous market demand.Through investigating widely, fully proving, showing that this market is still in low development status at present.Few for the natural biological cytothesis product of wound healing both at home and abroad, market product weak curative effect, can not meet the demand of patient.
Summary of the invention
The object of the present invention is to provide a kind of polysaccharide bio-medical colloidal solution, by the following technical solutions:
A kind of polysaccharide bio-medical colloidal solution, described colloidal solution comprises by weight percentage: low-viscosity sodium carboxymethyl cellulose 0.2-5%, medium viscosity sodium carboxymethyl cellulose 0.2-4%, high-viscosity sodium carboxymethyl cellulose 0.2-2%, sodium chloride 0.5-1.5%, all the other are water for injection.
Further, described colloidal solution comprises by weight percentage: low-viscosity sodium carboxymethyl cellulose 0.2%, medium viscosity sodium carboxymethyl cellulose 0.2%, high-viscosity sodium carboxymethyl cellulose 0.2%, sodium chloride 0.9%, all the other are water for injection.
Further, described colloidal solution comprises by weight percentage: low-viscosity sodium carboxymethyl cellulose 4.6%, medium viscosity sodium carboxymethyl cellulose 2.5%, high-viscosity sodium carboxymethyl cellulose 0.3%, sodium chloride 1.2%, all the other are water for injection.
Further, a kind of preparation method of polysaccharide bio-medical colloidal solution is provided, its preparation method comprises the following steps: sodium chloride is dissolved in water for injection, then in water, add basic, normal, high viscosity carboxymethyl cellulose sodium open calorstat, mechanical agitation at temperature 50-90 DEG C, until sodium carboxymethyl cellulose dissolves completely, obtain polysaccharide bio-medical colloidal solution.
Effect of the present invention is: polysaccharide biogum body fluid of the present invention forms modest viscosity by the optimization of formula; be easy to rinse; and form reliable, even, soft protecting film at wound surface; and form wound surface wet environment; directly cicatrization can be suppressed for cytothesis; also protecting film can be formed by wound surface; block antibacterial to encroach on wound surface; anti-bacteria is in the absorption of wound surface, and propagation, the process such as to copy; this product has no side effect; have larger clinical value, healing time is short, and healing rate is high.
Detailed description of the invention
Embodiment 1
A kind of polysaccharide bio-medical colloidal solution comprises by weight percentage: low-viscosity sodium carboxymethyl cellulose 0.3%, medium viscosity sodium carboxymethyl cellulose 1.2%, high-viscosity sodium carboxymethyl cellulose 0.4%, sodium chloride 0.9%, all the other are water for injection.Sodium chloride is dissolved in water for injection, in water, then adds basic, normal, high viscosity carboxymethyl cellulose sodium open calorstat, mechanical agitation at temperature 65 DEG C, until basic, normal, high viscosity carboxymethyl cellulose sodium dissolves completely, obtain polysaccharide bio-medical colloidal solution.
Embodiment 2
A kind of polysaccharide bio-medical colloidal solution, comprises: low-viscosity sodium carboxymethyl cellulose 1.5%, medium viscosity sodium carboxymethyl cellulose 2.2%, high-viscosity sodium carboxymethyl cellulose 0.7%, sodium chloride 1.0% by weight percentage, all the other are water for injection.Sodium chloride is dissolved in water for injection, in water, then adds basic, normal, high viscosity carboxymethyl cellulose sodium open calorstat, mechanical agitation under temperature 70 C, until basic, normal, high viscosity carboxymethyl cellulose sodium dissolves completely, obtain polysaccharide bio-medical colloidal solution.
This embodiment only for explaining the present invention, does not form limiting the scope of the present invention.
Claims (4)
1. a polysaccharide bio-medical colloidal solution, it is characterized in that: described colloidal solution comprises by weight percentage: low-viscosity sodium carboxymethyl cellulose 0.2-5%, medium viscosity sodium carboxymethyl cellulose 0.2-4%, high-viscosity sodium carboxymethyl cellulose 0.2-2%, sodium chloride 0.5-1.5%,, all the other are water for injection.
2. polysaccharide bio-medical colloidal solution as claimed in claim 1, it is characterized in that: described colloidal solution comprises by weight percentage: low-viscosity sodium carboxymethyl cellulose 0.2%, medium viscosity sodium carboxymethyl cellulose 0.2%, high-viscosity sodium carboxymethyl cellulose 0.2%, sodium chloride 0.9%,, all the other are water for injection.
3. polysaccharide bio-medical colloidal solution as claimed in claim 1, it is characterized in that: described colloidal solution comprises by weight percentage: low-viscosity sodium carboxymethyl cellulose 4.6%, medium viscosity sodium carboxymethyl cellulose 2.5%, high-viscosity sodium carboxymethyl cellulose 0.3%, sodium chloride 1.2%,, all the other are water for injection.
4. the preparation method of the polysaccharide bio-medical colloidal solution as described in claim 1-3, it is characterized in that: its preparation method comprises the following steps: sodium chloride is dissolved in water for injection, then in water, add basic, normal, high viscosity carboxymethyl cellulose sodium open calorstat, mechanical agitation at temperature 50-90 DEG C, until sodium carboxymethyl cellulose dissolves completely, obtain polysaccharide bio-medical colloidal solution.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107441548A (en) * | 2016-05-30 | 2017-12-08 | 江苏斯微特医药科技有限公司 | A kind of polysaccharide biological wound-surface nursing spray and preparation method thereof |
| CN107441559A (en) * | 2016-05-30 | 2017-12-08 | 任汉学 | Hypertonic nasal nursing spray of a kind of polysaccharide biology and preparation method thereof |
| CN107441560A (en) * | 2016-05-30 | 2017-12-08 | 任汉学 | A kind of polysaccharide biology nasal nursing spray and preparation method thereof |
| CN107537057A (en) * | 2016-06-24 | 2018-01-05 | 任汉学 | A kind of hypertonic polysaccharide biological hydrogel dressing and preparation method thereof |
| CN107537058A (en) * | 2016-06-24 | 2018-01-05 | 任汉学 | A kind of polysaccharide biological hydrogel dressing and preparation method thereof |
| CN113769103A (en) * | 2021-10-11 | 2021-12-10 | 中山大学 | Mesenchymal stem cell preparation for treating diabetic skin ulcer and preparation method thereof |
| CN114948998A (en) * | 2022-06-01 | 2022-08-30 | 复旦大学附属中山医院 | Polysaccharide biomedical colloidal fluid rich in human adipose-derived mesenchymal stem cell factor compound and preparation method and application thereof |
Citations (3)
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| CN103751833A (en) * | 2014-01-28 | 2014-04-30 | 北京百利康生化有限公司 | Medical antibacterial wound dressing and preparation method thereof |
| CN104130434A (en) * | 2013-05-02 | 2014-11-05 | 3M创新有限公司 | Hydrocolloid dressing and preparation method thereof |
| CN104784741A (en) * | 2015-04-23 | 2015-07-22 | 武汉市思泰利医疗器械发展有限公司 | Functional medical dressing containing chitosan and hydrocolloid |
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2015
- 2015-09-11 CN CN201510577511.4A patent/CN105126159B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104130434A (en) * | 2013-05-02 | 2014-11-05 | 3M创新有限公司 | Hydrocolloid dressing and preparation method thereof |
| CN103751833A (en) * | 2014-01-28 | 2014-04-30 | 北京百利康生化有限公司 | Medical antibacterial wound dressing and preparation method thereof |
| CN104784741A (en) * | 2015-04-23 | 2015-07-22 | 武汉市思泰利医疗器械发展有限公司 | Functional medical dressing containing chitosan and hydrocolloid |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107441548A (en) * | 2016-05-30 | 2017-12-08 | 江苏斯微特医药科技有限公司 | A kind of polysaccharide biological wound-surface nursing spray and preparation method thereof |
| CN107441559A (en) * | 2016-05-30 | 2017-12-08 | 任汉学 | Hypertonic nasal nursing spray of a kind of polysaccharide biology and preparation method thereof |
| CN107441560A (en) * | 2016-05-30 | 2017-12-08 | 任汉学 | A kind of polysaccharide biology nasal nursing spray and preparation method thereof |
| CN107537057A (en) * | 2016-06-24 | 2018-01-05 | 任汉学 | A kind of hypertonic polysaccharide biological hydrogel dressing and preparation method thereof |
| CN107537058A (en) * | 2016-06-24 | 2018-01-05 | 任汉学 | A kind of polysaccharide biological hydrogel dressing and preparation method thereof |
| CN113769103A (en) * | 2021-10-11 | 2021-12-10 | 中山大学 | Mesenchymal stem cell preparation for treating diabetic skin ulcer and preparation method thereof |
| CN113769103B (en) * | 2021-10-11 | 2023-12-05 | 中山大学 | Mesenchymal stem cell preparation for treating diabetic skin ulcer and preparation method thereof |
| CN114948998A (en) * | 2022-06-01 | 2022-08-30 | 复旦大学附属中山医院 | Polysaccharide biomedical colloidal fluid rich in human adipose-derived mesenchymal stem cell factor compound and preparation method and application thereof |
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| CN105126159B (en) | 2017-12-08 |
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