CN105055648A - Anti-aging Chinese herbal medicinal health oral liquid containing shark cartilage powder and preparation method of oral liquid - Google Patents
Anti-aging Chinese herbal medicinal health oral liquid containing shark cartilage powder and preparation method of oral liquid Download PDFInfo
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Abstract
The invention discloses an anti-aging Chinese herbal medicinal health oral liquid containing shark cartilage powder. According to raw material formula of the product, every 1000 parts of the health oral liquid consists of the following Chinese herbal medicinal raw material: 40-60 parts of shark cartilage powder, 10-15 parts of astragalus membranaceus, 8-12 parts of lucid ganoderma, 10-15 parts of rhodiola rosea, 15-20 parts of fiveleaf gynostemma herb, 10-13 parts of pseudo-ginseng, 8-12 parts of bighead atractylodes rhizome, 10-15 parts of fruit of Chinese magnoliavine, 10-16 parts of fruit of Chinese wolfberry, 10-18 parts of acanthopanax root, 5-10 parts of codonopsis pilosula, 5-10 parts of radix angelicae sinensis, 10-15 parts of liquorice root and 10-15 parts of leaves of stevia rebaudiana; and the oral liquid is prepared through a process combining ultrasonic-assisted extraction, volatile oil distillation, water decoction and alcohol extraction. The product has the advantages of being good in anti-aging function, safe and free from side effect, convenient to drink and the like.
Description
Technical field
The present invention relates to a kind of defying age shark cartilage powder herbal health care oral liquid, particularly a kind of health care oral liquid made for raw material with shark cartilage powder and vegetable Chinese herbal medicine, belong to healthcare field.
Background technology
Shark is one of ancient, the most long-lived in the world deep-sea marine organisms, and survived on earth 400,000,000 years, it has improves immune system, vitality is extremely strong, infected by the disease hardly, even if be subject to wound, wound also can restore very soon, and the cancered probability of shark is about 1,/00 ten thousand.China shark is medicinal first appeared in Collective Notes to the Canon of Materia medica, its cartilage is formed primarily of chondrocyte with containing collagen fiber and a large amount of proteoglycan and extracellular matrix, and the polysaccharide extracted from shark cartilage is mainly used in treatment neuralgia, migraine, abdominal postoperative pain etc. clinically.In Europe, the United States, Deng developed country, shark cartilage polysaccharide as health food or health care medicine prolonged application in disease such as control coronary heart diseases and angina pectoris, myocardial infarction etc., without obvious toxic and side effects.Recent study shows in shark cartilage except being rich in the mineral such as calcium, phosphorus, magnesium, and also containing multiple mucopolysaccharide and chondroitin sulfate, having the functions such as significant defying age, blood fat reducing, antiviral and antitumor, is rare wholefood resource.
Aging is that each organ of body engenders the progressive process that hypofunction and reserve capabillity decline along with the continuous increase at age, and with advancing age, the same miopragia of various organs of human body, produces various pathological changes, little by little enters ageing state.Therefore prevention and slow down aging have become current social medical research focus.Chinese herbal medicine resource is the rarity of Chinese traditional culture, because of its effect significantly, green, safely, have no side effect, the application in field of health care food is further extensive.Chinese medicine is thought: the main cause of human senility is deficient five internal organs, disorder of QI and blood etc., and by nourishing the five internal organs, QI and blood regulating is the important means of traditional Chinese medical science slow down aging.The research of Chinese medicine in defying age has the advantage of rich experience and uniqueness.Along with the continuous enhancing of people's prevention and health care consciousness, society increases day by day to the demand with function of delaying senility health food.Result of study shows, the health product utilizing Chinese herbal medicine to develop contain abundant nutritional labeling, be rich in trace element, the vitamin isoreactivity nutritional labelings such as polysaccharide, flavone, aminoacid, potassium calcium, there is adjustment function of human body, the effects such as enhancing immunity, nourishing and fit keeping function, life lengthening.
Summary of the invention
For overcoming the deficiency of existing product technology, the object of the present invention is to provide a kind of herbal health care oral liquid with senile-resistant efficacy.
Above-mentioned purpose of the present invention is achieved by the following technical programs:
The invention provides a kind of defying age shark cartilage powder herbal health care oral liquid, it is characterized in that: in 1000 portions of oral liquids, raw material of Chinese medicine and quality proportioning are: shark cartilage powder 40 ~ 60 parts, the Radix Astragali 10 ~ 15 parts, Ganoderma 8 ~ 12 parts, Radix Rhodiolae 10 ~ 15 parts, Herb Gynostemmae Pentaphylli 15 ~ 20 parts, Radix Notoginseng 10 ~ 13 parts, the Rhizoma Atractylodis Macrocephalae 8 ~ 12 parts, Fructus Schisandrae Chinensis 10 ~ 15 parts, Fructus Lycii 10 ~ 16 parts, Radix Et Caulis Acanthopanacis Senticosi 10 ~ 18 parts, Radix Codonopsis 5 ~ 10 parts, Radix Angelicae Sinensis 5 ~ 10 parts, 10 ~ 15 parts, Radix Glycyrrhizae, Folium Stevlae Rebaudianae 10 ~ 15 parts.
The preferred technical solution of the present invention is: a kind of defying age shark cartilage powder herbal health care oral liquid, is characterized in that: its raw material of Chinese medicine and quality proportioning are: shark cartilage powder 50 parts, the Radix Astragali 13 parts, Ganoderma 12 parts, Radix Rhodiolae 12 parts, Herb Gynostemmae Pentaphylli 16 parts, Radix Notoginseng 12 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Fructus Schisandrae Chinensis 14 parts, Fructus Lycii 15 parts, Radix Et Caulis Acanthopanacis Senticosi 15 parts, Radix Codonopsis 7 parts, Radix Angelicae Sinensis 7 parts, 12 parts, Radix Glycyrrhizae, Folium Stevlae Rebaudianae 13 parts.
The invention provides a kind of defying age shark cartilage powder herbal health care oral liquid, it is characterized in that being prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, removes impurity etc., weighs according to aforementioned proportion;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after the Radix Astragali, Ganoderma, Radix Rhodiolae, Herb Gynostemmae Pentaphylli, the Rhizoma Atractylodis Macrocephalae, Radix Notoginseng, Fructus Schisandrae Chinensis, Radix Et Caulis Acanthopanacis Senticosi, Radix Codonopsis, Radix Angelicae Sinensis, Radix Glycyrrhizae, Folium Stevlae Rebaudianae mixing, cross 40 mesh sieves;
2. in Fructus Lycii, add 2 ~ 3 times of pure water, making beating, then adds 1 ~ 2% pectase, enzymolysis 10 ~ 20min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 3 ~ 5 times of pure water after raw material mixing, then raw materials quality is added than 2 ~ 3% cellulase, 1 ~ 2% non-starch polysaccharide enzyme, enzymolysis 30 ~ 60min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 3 ~ 5 times amount in Chinese herbal medicine residue, collect volatile oil 8 ~ 10h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 1.5 ~ 2.0% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 2 ~ 3 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.5 ~ 2h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 4 ~ 6 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1 ~ 1.5h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add shark cartilage powder and the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.10 ~ 0.15% and the sweeting agent of 1 ~ 2%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 5 ~ 10min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
The mixture of one or more that what above-mentioned sweeting agent was selected is in xylitol, oligomeric isomaltose, Mel.
The invention provides a kind of defying age shark cartilage powder herbal health care oral liquid, it is advantageous that: one is selected prescription under Traditional Chinese medical theory and practical advice, scientific compatibility shark cartilage powder and multiple Chinese herbal medicine, and drug component is through dialectical compatibility, help using mutually assistant, can remarkable defying age; Two is the technique adopting " Ultrasonic Wave-Assisted Extraction+volatile matter distillation oil+decocting+alcohol extraction " in the preparation process of oral liquid, fully mixes the antidotal functional active components in Chinese herbal medicine, improves health-care effect; Three is that oral liquid has no side effect safely, drinks conveniently.
The invention provides a kind of defying age shark cartilage powder herbal health care oral liquid, carried out toxicology test and the safety evaluatio of health care oral liquid by animal experiment.Chmice acute Oral toxicity result of the test shows, this health care oral liquid is greater than high dose group 75mg/kgbw to chmice acute per os maximum tolerated dose; Genetic toxicity test mouse marrow cell micro nuclear test and mouse inbred strain two result of the tests are feminine gender, show that this health care oral liquid is without mutagenic action; From rat 30d feeding trial, the behavior of rat sign is normal, figure is healthy, blood and blood parameters also change without exception, and therefore the dosage (150 times of human body recommended amounts) of 75mg/kgbw belongs to safe dose; Genetic toxicity test and rat 30d feeding trial result are feminine gender, therefore determine that this health beverage belongs to non-toxic type food, and people can be safe relieved edible.
The invention provides a kind of defying age shark cartilage powder herbal health care oral liquid, different Chinese herbal medicine nature and flavor are different, effect also exists huge difference, complicated interaction relationship is there is after different Chinese herbal medicine combinations, and proportioning between Chinese herbal medicine is closer, different ratio also will make monarch relation that substantial change occurs, thus make the relation generation material alterations of composite Chinese herbal.Complicated interaction relationship is there is to each other in the application by Chinese herbal medicine such as shark cartilage powder, the Radix Astragali, Ganoderma, Radix Rhodiolae, Herb Gynostemmae Pentaphylli, Radix Notoginseng, the Rhizoma Atractylodis Macrocephalae, Fructus Schisandrae Chinensis, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Radix Codonopsis, Radix Angelicae Sinensis, Radix Glycyrrhizae, Folium Stevlae Rebaudianae, rational proportion, achieve unforeseeable technique effect, make the relation generation material alterations of defying age herbal health care oral liquid.According to " function of health food assessment process and the method for inspection ", Evaluation of Functional is carried out to the application's product, rat test is utilized to measure health care oral liquid to the impact on one of aging index-peroxidation lipid, after result shows to feed 3 months, experimental group serum MDA value is lower than matched group, liver homogenate MDA and brain homogenate MDA comparatively matched group reduces by 29.45% and 28.77%, comparatively matched group significant difference (p<0.01), illustrates that product has good activity of fighting against senium; In addition, result of the test shows, change shark cartilage powder and the composition of Chinese herbal medicine and effect of reduction product more remarkable in regular meeting, result difference significantly (p<0.01), illustrates that the synergism between shark cartilage powder and Chinese herbal medicine serves the effect significantly promoting oral liquid functional activity.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
embodiment 1:
A kind of defying age shark cartilage powder herbal health care oral liquid, prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, remove impurity etc., weigh according to shark cartilage powder 50 parts, the Radix Astragali 13 parts, Ganoderma 12 parts, Radix Rhodiolae 12 parts, Herb Gynostemmae Pentaphylli 16 parts, Radix Notoginseng 12 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Fructus Schisandrae Chinensis 14 parts, Fructus Lycii 15 parts, Radix Et Caulis Acanthopanacis Senticosi 15 parts, Radix Codonopsis 7 parts, Radix Angelicae Sinensis 7 parts, 12 parts, Radix Glycyrrhizae, Folium Stevlae Rebaudianae 13 parts of ratios in every 1000 portions of oral liquids;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after the Radix Astragali, Ganoderma, Radix Rhodiolae, Herb Gynostemmae Pentaphylli, the Rhizoma Atractylodis Macrocephalae, Fructus Schisandrae Chinensis, Radix Et Caulis Acanthopanacis Senticosi, Radix Notoginseng, Radix Codonopsis, Radix Angelicae Sinensis, Radix Glycyrrhizae, Folium Stevlae Rebaudianae mixing, cross 40 mesh sieves;
2. in Fructus Lycii, add 2.5 times of pure water, making beating, then adds 1.5% pectase, enzymolysis 15min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 4 times of pure water after raw material mixing, then add raw materials quality than 2.5% cellulase, 1.5% non-starch polysaccharide enzyme, enzymolysis 45min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 4 times amount in Chinese herbal medicine residue, collect volatile oil 9h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 1.8% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 2.5 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.8h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 5 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1.2h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add shark cartilage powder and the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.12% and the xylitol of 1.5%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 8min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
embodiment 2:
A kind of defying age shark cartilage powder herbal health care oral liquid, prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, remove impurity etc., weigh according to shark cartilage powder 60 parts, the Radix Astragali 10 parts, Ganoderma 12 parts, Radix Rhodiolae 10 parts, Herb Gynostemmae Pentaphylli 20 parts, Radix Notoginseng 10 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Fructus Schisandrae Chinensis 10 parts, Fructus Lycii 16 parts, Radix Et Caulis Acanthopanacis Senticosi 10 parts, Radix Codonopsis 5 parts, Radix Angelicae Sinensis 10 parts, 15 parts, Radix Glycyrrhizae, Folium Stevlae Rebaudianae 10 parts of ratios in every 1000 portions of oral liquids;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after the Radix Astragali, Ganoderma, Radix Rhodiolae, Herb Gynostemmae Pentaphylli, the Rhizoma Atractylodis Macrocephalae, Fructus Schisandrae Chinensis, Radix Et Caulis Acanthopanacis Senticosi, Radix Notoginseng, Radix Codonopsis, Radix Angelicae Sinensis, Radix Glycyrrhizae, Folium Stevlae Rebaudianae mixing, cross 40 mesh sieves;
2. in Fructus Lycii, add 3 times of pure water, making beating, then adds 2% pectase, enzymolysis 10min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 5 times of pure water after raw material mixing, then add raw materials quality than 3% cellulase, 2% non-starch polysaccharide enzyme, enzymolysis 30min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 5 times amount in Chinese herbal medicine residue, collect volatile oil 8h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 2.0% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 3 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.5h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 6 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add shark cartilage powder and the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.15% and the oligomeric isomaltose of 2%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 10min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
embodiment 3:
A kind of defying age shark cartilage powder herbal health care oral liquid, prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, remove impurity etc., weigh according to shark cartilage powder 40 parts, the Radix Astragali 15 parts, Ganoderma 8 parts, Radix Rhodiolae 15 parts, Herb Gynostemmae Pentaphylli 15 parts, Radix Notoginseng 13 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, Fructus Schisandrae Chinensis 15 parts, Fructus Lycii 10 parts, Radix Et Caulis Acanthopanacis Senticosi 18 parts, Radix Codonopsis 10 parts, Radix Angelicae Sinensis 5 parts, 10 parts, Radix Glycyrrhizae, Folium Stevlae Rebaudianae 15 parts of ratios in every 1000 portions of oral liquids;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after the Radix Astragali, Ganoderma, Radix Rhodiolae, Herb Gynostemmae Pentaphylli, the Rhizoma Atractylodis Macrocephalae, Fructus Schisandrae Chinensis, Radix Et Caulis Acanthopanacis Senticosi, Radix Notoginseng, Radix Codonopsis, Radix Angelicae Sinensis, Radix Glycyrrhizae, Folium Stevlae Rebaudianae mixing, cross 40 mesh sieves;
2. in Fructus Lycii, add 2 times of pure water, making beating, then adds 1% pectase, enzymolysis 20min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 3 times of pure water after raw material mixing, then add raw materials quality than 2% cellulase, 1% non-starch polysaccharide enzyme, enzymolysis 60min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 3 times amount in Chinese herbal medicine residue, collect volatile oil 10h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 1.5% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 2 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 2h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 4 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1.5h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add shark cartilage powder and the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.10% and the Mel of 1%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 5 ~ 10min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
Above embodiment only for illustration of technical scheme of the present invention, but not is limited; Although be described in detail by invention with reference to previous embodiment, for the person of ordinary skill of the art, still the technical scheme described in previous embodiment can be modified, or equivalent replacement has been carried out to wherein portion of techniques feature; And to these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of the present invention's technical scheme required for protection.
Claims (2)
1. a defying age shark cartilage powder herbal health care oral liquid, is characterized in that being prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, remove impurity etc., weigh according to every 1000 parts of oral liquid Raw quality proportioning shark cartilage powders 40 ~ 60 parts, the Radix Astragali 10 ~ 15 parts, Ganoderma 8 ~ 12 parts, Radix Rhodiolae 10 ~ 15 parts, Herb Gynostemmae Pentaphylli 15 ~ 20 parts, Radix Notoginseng 10 ~ 13 parts, the Rhizoma Atractylodis Macrocephalae 8 ~ 12 parts, Fructus Schisandrae Chinensis 10 ~ 15 parts, Fructus Lycii 10 ~ 16 parts, Radix Et Caulis Acanthopanacis Senticosi 10 ~ 18 parts, Radix Codonopsis 5 ~ 10 parts, Radix Angelicae Sinensis 5 ~ 10 parts, 10 ~ 15 parts, Radix Glycyrrhizae, Folium Stevlae Rebaudianae 10 ~ 15 parts;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after the Radix Astragali, Ganoderma, Radix Rhodiolae, Herb Gynostemmae Pentaphylli, the Rhizoma Atractylodis Macrocephalae, Radix Notoginseng, Fructus Schisandrae Chinensis, Radix Et Caulis Acanthopanacis Senticosi, Radix Codonopsis, Radix Angelicae Sinensis, Radix Glycyrrhizae, Folium Stevlae Rebaudianae mixing, cross 40 mesh sieves;
2. in Fructus Lycii, add 2 ~ 3 times of pure water, making beating, then adds 1 ~ 2% pectase, enzymolysis 10 ~ 20min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 3 ~ 5 times of pure water after raw material mixing, then raw materials quality is added than 2 ~ 3% cellulase, 1 ~ 2% non-starch polysaccharide enzyme, enzymolysis 30 ~ 60min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 3 ~ 5 times amount in Chinese herbal medicine residue, collect volatile oil 8 ~ 10h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 1.5 ~ 2.0% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 2 ~ 3 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.5 ~ 2h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 4 ~ 6 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1 ~ 1.5h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add shark cartilage powder and the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.10 ~ 0.15% and the sweeting agent of 1 ~ 2%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 5 ~ 10min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
2. the herbal health care oral liquid of a kind of prevention and therapy diabetic retinopathy according to claim 1, what it is characterized in that described sweeting agent selects is the mixture of one or more in xylitol, oligomeric isomaltose, Mel.
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| CN105998732A (en) * | 2016-06-27 | 2016-10-12 | 青岛铭晨信息技术有限公司 | Anti-aging Chinese herb healthcare oral liquid and preparation method |
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| CN109198609A (en) * | 2017-07-06 | 2019-01-15 | 李月江 | Xylitol shark bone face-beautifying health product and its preparation process |
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| CN105595325A (en) * | 2015-12-19 | 2016-05-25 | 青岛铭晨信息技术有限公司 | Globefish fish skin health care capsule with stomach strengthening effect |
| CN105477369A (en) * | 2015-12-21 | 2016-04-13 | 青岛浩大海洋保健食品有限公司 | Anti-aging Chinese herbal medicinal health oral liquid containing seaweed protein and preparation method of anti-aging Chinese herbal medicinal health oral liquid |
| CN106036865A (en) * | 2016-06-23 | 2016-10-26 | 青岛浩大海洋保健食品有限公司 | Euphausia superba oil tonic oral liquid with efficacy of resisting fatigue |
| CN105998732A (en) * | 2016-06-27 | 2016-10-12 | 青岛铭晨信息技术有限公司 | Anti-aging Chinese herb healthcare oral liquid and preparation method |
| CN109198609A (en) * | 2017-07-06 | 2019-01-15 | 李月江 | Xylitol shark bone face-beautifying health product and its preparation process |
| CN109349632A (en) * | 2018-11-16 | 2019-02-19 | 安徽迎春草生物科技有限公司 | A kind of anti-aging is welcomed spring careless oral solution and preparation method thereof |
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