CN105998732A - Anti-aging Chinese herb healthcare oral liquid and preparation method - Google Patents
Anti-aging Chinese herb healthcare oral liquid and preparation method Download PDFInfo
- Publication number
- CN105998732A CN105998732A CN201610477436.9A CN201610477436A CN105998732A CN 105998732 A CN105998732 A CN 105998732A CN 201610477436 A CN201610477436 A CN 201610477436A CN 105998732 A CN105998732 A CN 105998732A
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- China
- Prior art keywords
- parts
- radix
- oral liquid
- add
- volatile oil
- Prior art date
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Abstract
The invention discloses anti-aging Chinese herb healthcare oral liquid. Every 1,000 parts of the healthcare oral liquid is prepared from 40-60 parts of common seepweed herb, 10-15 parts of milkvetch roots, 8-12 parts of poria cocos, 10-15 parts of herba dendrobii, 15-20 parts of herba rhodiolae, 10-13 parts of radix rehmanniae, 8-12 parts of rhizoma atractylodis macrocephalae, 10-15 parts of Chinese galls, 10-16 parts of barbary wolfberry fruit, 10-18 parts of radix acanthopanacis semticosi, 5-10 parts of fructus corni, 5-10 parts of radix polygoni multiflori, 10-15 parts of licorice roots and 10-15 parts of sweet stevia through the processes including ultrasonic wave-assisted extraction, volatile oil distillation, water decoction and alcohol extraction. The anti-aging Chinese herb healthcare oral liquid has the advantages of being good in anti-aging effect, safe, free of side effects, convenient to drink and the like.
Description
Technical field
The present invention relates to a kind of defying age Herba suadeae glaucae herbal health care oral liquid, a kind of health care oral liquid made for raw material with Herba suadeae glaucae and vegetable Chinese herbal medicine, belong to field of health care food.
Background technology
Herba suadeae glaucae not only has significant application value in improvement saline-alkali environment, and be a kind of quality vegetables, industrial crops and the plant resources with value medical health care, particularly day by day embody today of its important effect at basic food, in the great using value of field of food health care.Herba suadeae glaucae is nutritious, stem and leaf and seed nutritional labeling are the most complete, in addition to rich in fat, protein, the rich content of mineral, trace element and vitamin, such as, the fresh taper of 100g Herba suadeae glaucae divides containing carotene 1.75mg, vitamin B2 20.10mg, vitamin C 78mg, possibly together with other trace element, such as Ca, P, Fe, Zn, Se etc., many of which index is all higher than spirulina. and in Herba suadeae glaucae, Ca, P, Fe content is higher than vegetables such as Herba Spinaciae, Fructus Lycopersici esculenti and Radix Dauci Sativaes;Vitamin C content is higher than or is equivalent to general vegetable;Vitamin B2 content is 5~8 times of general vegetable;More general food is measured high about 10 times containing Se.
Aging is the progressive process that each organ of body engenders that along with being continuously increased of age hypofunction and reserve capabillity decline, with advancing age, the same miopragia of various organs of human body, produces various pathological changes, little by little enters ageing state.Therefore prevention and slow down aging have become current social medical research focus.Chinese herbal medicine resource is the rarity of Chinese traditional culture, because its effect is notable, green, safely, have no side effect, the application in field of health care food is the most extensive.Chinese medicine is thought: the main cause of human senility is deficient five internal organs, disorder of QI and blood etc., and by nourishing the five internal organs, QI and blood regulating is the important means of traditional Chinese medical science slow down aging.Chinese medicine research in terms of defying age has the advantage of rich experience and uniqueness.Along with the continuous enhancing of people's prevention and health care consciousness, the demand with function of delaying senility health food is increased by society day by day.Result of study shows, the health product utilizing Chinese herbal medicine development contain abundant nutritional labeling, rich in trace element, vitamin isoreactivity nutritional labelings such as polysaccharide, flavone, aminoacid, potassium calcium, there is the effects such as regulation function of human body, enhancing immunity, nourishing and fit keeping function, life lengthening.
Summary of the invention
For overcoming the deficiency of existing product technology, it is an object of the invention to provide a kind of herbal health care oral liquid with senile-resistant efficacy.
Above-mentioned purpose of the present invention is achieved by the following technical programs:
The present invention provides a kind of defying age Herba suadeae glaucae herbal health care oral liquid, it is characterised in that: in 1000 portions of oral liquids, raw material of Chinese medicine and quality proportioning are: Herba suadeae glaucae 40~60 parts, the Radix Astragali 10~15 parts, Poria 8~12 parts, Herba Dendrobii 10~15 parts, Radix Rhodiolae 15~20 parts, the Radix Rehmanniae 10~13 parts, the Rhizoma Atractylodis Macrocephalae 8~12 parts, Galla Chinensis 10~15 parts, Fructus Lycii 10~16 parts, Radix Et Caulis Acanthopanacis Senticosi 10~18 parts, Fructus Corni 5~10 parts, Radix Polygoni Multiflori 5~10 parts, Radix Glycyrrhizae 10~15 parts, Folium Stevlae Rebaudianae 10~15 parts.
The preferred technical solution of the present invention is: a kind of defying age Herba suadeae glaucae herbal health care oral liquid, it is characterised in that: its raw material of Chinese medicine and quality proportioning be: Herba suadeae glaucae 50 parts, the Radix Astragali 13 parts, 12 parts of Poria, Herba Dendrobii 12 parts, Radix Rhodiolae 16 parts, 12 parts of the Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae 10 parts, Galla Chinensis 14 parts, Fructus Lycii 15 parts, Radix Et Caulis Acanthopanacis Senticosi 15 parts, Fructus Corni 7 parts, Radix Polygoni Multiflori 7 parts, 12 parts of Radix Glycyrrhizae, Folium Stevlae Rebaudianae 13 parts.
The present invention provides a kind of defying age Herba suadeae glaucae herbal health care oral liquid, it is characterised in that prepared by following steps:
(1) sorting weighs: is sorted by Chinese herbal medicine used, goes the removal of impurity etc., weighs according to aforementioned proportion;
(2) pretreatment of raw material: carry out pretreatment of raw material according to property of raw material difference respectively:
1. after Herba suadeae glaucae, the Radix Astragali, Poria, Herba Dendrobii, Radix Rhodiolae, the Rhizoma Atractylodis Macrocephalae, the Radix Rehmanniae, Galla Chinensis, Radix Et Caulis Acanthopanacis Senticosi, Fructus Corni, Radix Polygoni Multiflori, Radix Glycyrrhizae, Folium Stevlae Rebaudianae mixing, carry out pulverization process, cross 40 mesh sieves;
2. in Fructus Lycii, add 2~3 times of pure water, making beating, be subsequently adding 1~2% pectase, enzymolysis 10~20min under the conditions of 40~50 DEG C;
(3) ultrasound-assisted enzymolysis: add raw materials quality after raw material mixing than 3~5 times of pure water, it is subsequently adding raw materials quality than 2~3% cellulase, 1~2% non-starch polysaccharide enzyme, enzymolysis 30~60min under the conditions of ultrasonic assistant, hydrolysis temperature controls at 40~50 DEG C;
(4) centrifugal: centrifugation lixiviating solution and middle medicinal herbs residue;
(5) distillation: add the pure water of 3~5 times amount in Chinese herbal medicine residue, collects volatile oil 8~10h, and volatile oil is collected separately placement, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: addition 1.5~the cosolvent tween 80 of 2.0%, heating emulsification in the volatile oil that will collect;
(7) decocting: by adding the water of 2~3 times amount in the Chinese herbal medicine residue after distillation, decocting 3 times, each 1.5~2h, decocting liquid merges with lixiviating solution;
(8) concentrating under reduced pressure: the aqueous solution after merging is concentrated into the clear paste of 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60~70%, places more than 48h under the conditions of 4 DEG C
(10) alcohol extraction: add 50% ethanol of 4~6 times amount, heating extraction 2 times, extraction time 1~1.5h in the Chinese herbal medicine residue after decocting;
(11) sucking filtration is merged: the liquid after precipitate with ethanol is merged sucking filtration with alcohol extract;
(12) recovered under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol to without alcohol taste;
(13) mixing: add Herba suadeae glaucae and the good volatile oil of emulsifying while hot in concentrated solution, stir;
(14) adjuvant is added: addition 0.10~the potassium sorbate of 0.15% and 1~the sweeting agent of 2%, add water stirring constant volume;
(15) stand: more than 48h will be stood under oral liquid semi-finished product room temperature;
(16) centrifugal: oral liquid semi-finished product 3000r/min is centrifuged 5~10min;
(17) constant volume subpackage: oral liquid constant volume, subpackage after being centrifuged i.e. obtain oral liquid finished product.
What above-mentioned sweeting agent was selected is the mixture of one or more in xylitol, oligomeric isomaltose, Mel.
The present invention provides a kind of defying age Herba suadeae glaucae herbal health care oral liquid, it is advantageous that: one is selected prescription under Traditional Chinese medical theory and practical advice, scientific compatibility Herba suadeae glaucae and multiple Chinese herbal medicine, and drug component is through dialectical compatibility, help using mutually assistant, can notable defying age;Two is the technique using " Ultrasonic Wave-Assisted Extraction+volatile matter distillation oil+decocting+alcohol extraction " in the preparation process of oral liquid, fully mixes the functional active components of defying age in Chinese herbal medicine, improves health-care effect;Three is that oral liquid has no side effect safely, drinks conveniently.
The present invention provides a kind of defying age Herba suadeae glaucae herbal health care oral liquid, is carried out toxicology test and the safety evaluatio of health care oral liquid by animal experiment.Chmice acute Oral toxicity result of the test shows, this health care oral liquid is more than high dose group 75mg/kg bw to chmice acute per os maximum tolerated dose;Genetic toxicity test mouse marrow cell micro nuclear test and two result of the tests of mouse inbred strain are feminine gender, show that this health care oral liquid is without mutagenic action;From rat 30d feeding trial, rat sign behavior is normal, figure is healthy, blood and blood parameters change the most without exception, and therefore the dosage (150 times of human body recommended amounts) of 75mg/kg bw belongs to safe dose;Genetic toxicity test and rat 30d feeding trial result are feminine gender, it is thus determined that this health beverage belongs to non-toxic type food, people can be safe relieved edible.
The present invention provides a kind of defying age Herba suadeae glaucae herbal health care oral liquid, different Chinese herbal medicine nature and flavor are different, effect also exists huge difference, the interaction relationship of complexity is there is after different Chinese herbal medicine combinations, and proportioning between Chinese herbal medicine is closer, different ratio also will make monarch relation that substantial change occurs, so that the relation generation material alterations of composite Chinese herbal.The interaction relationship of complexity is there is to each other in the application by Chinese herbal medicine such as Herba suadeae glaucae, the Radix Astragali, Poria, Herba Dendrobii, Radix Rhodiolae, the Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, Galla Chinensis, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Fructus Corni, Radix Polygoni Multiflori, Radix Glycyrrhizae, Folium Stevlae Rebaudianae, rational proportion, achieve unforeseeable technique effect, make the relation generation material alterations of defying age herbal health care oral liquid.According to " function of health food assessment process and the method for inspection ", the application product is carried out Evaluation of Functional, rat test is utilized to measure health care oral liquid to the impact on one of aging index peroxidation lipid, after result shows to feed 3 months, experimental group serum MDA value is less than matched group, liver homogenate MDA and brain homogenate MDA relatively matched group reduce by 32.15% and 30.21%, relatively matched group significant difference (p < 0.01), illustrates that product has preferable activity of fighting against senium;In addition, result of the test shows, change Herba suadeae glaucae and the composition of Chinese herbal medicine and significantly reduce effect of product than regular meeting, result difference is notable (p < 0.01), illustrate that the synergism between Herba suadeae glaucae and Chinese herbal medicine serves the effect being obviously improved oral liquid functional activity, and product cost relatively equivalents declines more than 30%.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1:
A kind of defying age Herba suadeae glaucae herbal health care oral liquid, is prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, go the removal of impurity etc., weigh according to Herba suadeae glaucae 50 parts, the Radix Astragali 13 parts, 12 parts of Poria, Herba Dendrobii 12 parts, Radix Rhodiolae 16 parts, 12 parts of the Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae 10 parts, Galla Chinensis 14 parts, Fructus Lycii 15 parts, Radix Et Caulis Acanthopanacis Senticosi 15 parts, Fructus Corni 7 parts, Radix Polygoni Multiflori 7 parts, 12 parts of Radix Glycyrrhizae, 13 parts of ratios of Folium Stevlae Rebaudianae in every 1000 portions of oral liquids;
(2) pretreatment of raw material: carry out pretreatment of raw material according to property of raw material difference respectively:
1. after Herba suadeae glaucae, the Radix Astragali, Poria, Herba Dendrobii, Radix Rhodiolae, the Rhizoma Atractylodis Macrocephalae, Galla Chinensis, Radix Et Caulis Acanthopanacis Senticosi, the Radix Rehmanniae, Fructus Corni, Radix Polygoni Multiflori, Radix Glycyrrhizae, Folium Stevlae Rebaudianae mixing, carry out pulverization process, cross 40 mesh sieves;
2. in Fructus Lycii, add 2.5 times of pure water, making beating, be subsequently adding 1.5% pectase, enzymolysis 15min under the conditions of 40~50 DEG C;
(3) ultrasound-assisted enzymolysis: adding raw materials quality after raw material mixing than 4 times of pure water, be subsequently adding raw materials quality than 2.5% cellulase, 1.5% non-starch polysaccharide enzyme, enzymolysis 45min under the conditions of ultrasonic assistant, hydrolysis temperature controls at 40~50 DEG C;
(4) centrifugal: centrifugation lixiviating solution and middle medicinal herbs residue;
(5) distillation: add the pure water of 4 times amount in Chinese herbal medicine residue, collects volatile oil 9h, and volatile oil is collected separately placement, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: add the cosolvent tween 80 of 1.8%, heating emulsification in the volatile oil that will collect;
(7) decocting: by adding the water of 2.5 times amount in the Chinese herbal medicine residue after distillation, decocting 3 times, each 1.8h, decocting liquid merges with lixiviating solution;
(8) concentrating under reduced pressure: the aqueous solution after merging is concentrated into the clear paste of 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60~70%, places more than 48h under the conditions of 4 DEG C
(10) alcohol extraction: add 50% ethanol of 5 times amount, heating extraction 2 times, extraction time 1.2h in the Chinese herbal medicine residue after decocting;
(11) sucking filtration is merged: the liquid after precipitate with ethanol is merged sucking filtration with alcohol extract;
(12) recovered under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol to without alcohol taste;
(13) mixing: add Herba suadeae glaucae and the good volatile oil of emulsifying while hot in concentrated solution, stir;
(14) adjuvant is added: adding potassium sorbate and the xylitol of 1.5% of 0.12%, add water stirring constant volume;
(15) stand: more than 48h will be stood under oral liquid semi-finished product room temperature;
(16) centrifugal: oral liquid semi-finished product 3000r/min is centrifuged 8min;
(17) constant volume subpackage: oral liquid constant volume, subpackage after being centrifuged i.e. obtain oral liquid finished product.
Embodiment 2:
A kind of defying age Herba suadeae glaucae herbal health care oral liquid, is prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, go the removal of impurity etc., weigh according to Herba suadeae glaucae 60 parts, the Radix Astragali 10 parts, 12 parts of Poria, Herba Dendrobii 10 parts, Radix Rhodiolae 20 parts, 10 parts of the Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae 12 parts, Galla Chinensis 10 parts, Fructus Lycii 16 parts, Radix Et Caulis Acanthopanacis Senticosi 10 parts, Fructus Corni 5 parts, Radix Polygoni Multiflori 10 parts, 15 parts of Radix Glycyrrhizae, 10 parts of ratios of Folium Stevlae Rebaudianae in every 1000 portions of oral liquids;
(2) pretreatment of raw material: carry out pretreatment of raw material according to property of raw material difference respectively:
1. after Herba suadeae glaucae, the Radix Astragali, Poria, Herba Dendrobii, Radix Rhodiolae, the Rhizoma Atractylodis Macrocephalae, Galla Chinensis, Radix Et Caulis Acanthopanacis Senticosi, the Radix Rehmanniae, Fructus Corni, Radix Polygoni Multiflori, Radix Glycyrrhizae, Folium Stevlae Rebaudianae mixing, carry out pulverization process, cross 40 mesh sieves;
2. in Fructus Lycii, add 3 times of pure water, making beating, be subsequently adding 2% pectase, enzymolysis 10min under the conditions of 40~50 DEG C;
(3) ultrasound-assisted enzymolysis: adding raw materials quality after raw material mixing than 5 times of pure water, be subsequently adding raw materials quality than 3% cellulase, 2% non-starch polysaccharide enzyme, enzymolysis 30min under the conditions of ultrasonic assistant, hydrolysis temperature controls at 40~50 DEG C;
(4) centrifugal: centrifugation lixiviating solution and middle medicinal herbs residue;
(5) distillation: add the pure water of 5 times amount in Chinese herbal medicine residue, collects volatile oil 8h, and volatile oil is collected separately placement, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: add the cosolvent tween 80 of 2.0%, heating emulsification in the volatile oil that will collect;
(7) decocting: by adding the water of 3 times amount in the Chinese herbal medicine residue after distillation, decocting 3 times, each 1.5h, decocting liquid merges with lixiviating solution;
(8) concentrating under reduced pressure: the aqueous solution after merging is concentrated into the clear paste of 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60~70%, places more than 48h under the conditions of 4 DEG C
(10) alcohol extraction: add 50% ethanol of 6 times amount, heating extraction 2 times, extraction time 1h in the Chinese herbal medicine residue after decocting;
(11) sucking filtration is merged: the liquid after precipitate with ethanol is merged sucking filtration with alcohol extract;
(12) recovered under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol to without alcohol taste;
(13) mixing: add Herba suadeae glaucae and the good volatile oil of emulsifying while hot in concentrated solution, stir;
(14) adjuvant is added: adding potassium sorbate and the oligomeric isomaltose of 2% of 0.15%, add water stirring constant volume;
(15) stand: more than 48h will be stood under oral liquid semi-finished product room temperature;
(16) centrifugal: oral liquid semi-finished product 3000r/min is centrifuged 10min;
(17) constant volume subpackage: oral liquid constant volume, subpackage after being centrifuged i.e. obtain oral liquid finished product.
Embodiment 3:
A kind of defying age Herba suadeae glaucae herbal health care oral liquid, is prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, go the removal of impurity etc., weigh according to Herba suadeae glaucae 40 parts, the Radix Astragali 15 parts, 8 parts of Poria, Herba Dendrobii 15 parts, Radix Rhodiolae 15 parts, 13 parts of the Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae 8 parts, Galla Chinensis 15 parts, Fructus Lycii 10 parts, Radix Et Caulis Acanthopanacis Senticosi 18 parts, Fructus Corni 10 parts, Radix Polygoni Multiflori 5 parts, 10 parts of Radix Glycyrrhizae, 15 parts of ratios of Folium Stevlae Rebaudianae in every 1000 portions of oral liquids;
(2) pretreatment of raw material: carry out pretreatment of raw material according to property of raw material difference respectively:
1. after Herba suadeae glaucae, the Radix Astragali, Poria, Herba Dendrobii, Radix Rhodiolae, the Rhizoma Atractylodis Macrocephalae, Galla Chinensis, Radix Et Caulis Acanthopanacis Senticosi, the Radix Rehmanniae, Fructus Corni, Radix Polygoni Multiflori, Radix Glycyrrhizae, Folium Stevlae Rebaudianae mixing, carry out pulverization process, cross 40 mesh sieves;
2. in Fructus Lycii, add 2 times of pure water, making beating, be subsequently adding 1% pectase, enzymolysis 20min under the conditions of 40~50 DEG C;
(3) ultrasound-assisted enzymolysis: adding raw materials quality after raw material mixing than 3 times of pure water, be subsequently adding raw materials quality than 2% cellulase, 1% non-starch polysaccharide enzyme, enzymolysis 60min under the conditions of ultrasonic assistant, hydrolysis temperature controls at 40~50 DEG C;
(4) centrifugal: centrifugation lixiviating solution and middle medicinal herbs residue;
(5) distillation: add the pure water of 3 times amount in Chinese herbal medicine residue, collects volatile oil 10h, and volatile oil is collected separately placement, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: add the cosolvent tween 80 of 1.5%, heating emulsification in the volatile oil that will collect;
(7) decocting: by adding the water of 2 times amount in the Chinese herbal medicine residue after distillation, decocting 3 times, each 2h, decocting liquid merges with lixiviating solution;
(8) concentrating under reduced pressure: the aqueous solution after merging is concentrated into the clear paste of 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60~70%, places more than 48h under the conditions of 4 DEG C
(10) alcohol extraction: add 50% ethanol of 4 times amount, heating extraction 2 times, extraction time 1.5h in the Chinese herbal medicine residue after decocting;
(11) sucking filtration is merged: the liquid after precipitate with ethanol is merged sucking filtration with alcohol extract;
(12) recovered under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol to without alcohol taste;
(13) mixing: add Herba suadeae glaucae and the good volatile oil of emulsifying while hot in concentrated solution, stir;
(14) adjuvant is added: adding potassium sorbate and the Mel of 1% of 0.10%, add water stirring constant volume;
(15) stand: more than 48h will be stood under oral liquid semi-finished product room temperature;
(16) centrifugal: oral liquid semi-finished product 3000r/min is centrifuged 5~10min;
(17) constant volume subpackage: oral liquid constant volume, subpackage after being centrifuged i.e. obtain oral liquid finished product.
Above example is merely to illustrate technical scheme, rather than is limited;Although being described in detail by invention with reference to previous embodiment, but for the person of ordinary skill of the art, still the technical scheme described in previous embodiment can be modified, or wherein portion of techniques feature is carried out equivalent;And to these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of claimed technical solution of the invention.
Claims (2)
1. a defying age herbal health care oral liquid, it is characterised in that prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, go the removal of impurity etc., weigh according to raw materials quality proportioning Herba suadeae glaucae 40 in every 1000 portions of oral liquids~60 parts, the Radix Astragali 10~15 parts, Poria 8~12 parts, Herba Dendrobii 10~15 parts, Radix Rhodiolae 15~20 parts, the Radix Rehmanniae 10~13 parts, the Rhizoma Atractylodis Macrocephalae 8~12 parts, Galla Chinensis 10~15 parts, Fructus Lycii 10~16 parts, Radix Et Caulis Acanthopanacis Senticosi 10~18 parts, Fructus Corni 5~10 parts, Radix Polygoni Multiflori 5~10 parts, Radix Glycyrrhizae 10~15 parts, Folium Stevlae Rebaudianae 10~15 parts;
(2) pretreatment of raw material: carry out pretreatment of raw material according to property of raw material difference respectively:
1. after Herba suadeae glaucae, Radix Scutellariae, Poria, Herba Dendrobii, Herb Gynostemmae Pentaphylli, the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata, Galla Chinensis, Radix Et Caulis Acanthopanacis Senticosi, Radix Codonopsis, Herba Epimedii, Radix Glycyrrhizae, Folium Stevlae Rebaudianae mixing, carry out pulverization process, cross 40 mesh sieves;
2. in Fructus Lycii, add 2~3 times of pure water, making beating, be subsequently adding 1~2% pectase, enzymolysis 10~20min under the conditions of 40~50 DEG C;
(3) ultrasound-assisted enzymolysis: add raw materials quality after raw material mixing than 3~5 times of pure water, it is subsequently adding raw materials quality than 2~3% cellulase, 1~2% non-starch polysaccharide enzyme, enzymolysis 30~60min under the conditions of ultrasonic assistant, hydrolysis temperature controls at 40~50 DEG C;
(4) centrifugal: centrifugation lixiviating solution and middle medicinal herbs residue;
(5) distillation: add the pure water of 3~5 times amount in Chinese herbal medicine residue, collects volatile oil 8~10h, and volatile oil is collected separately placement, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: addition 1.5~the cosolvent tween 80 of 2.0%, heating emulsification in the volatile oil that will collect;
(7) decocting: by adding the water of 2~3 times amount in the Chinese herbal medicine residue after distillation, decocting 3 times, each 1.5~2h, decocting liquid merges with lixiviating solution;
(8) concentrating under reduced pressure: the aqueous solution after merging is concentrated into the clear paste of 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60~70%, places more than 48h under the conditions of 4 DEG C
(10) alcohol extraction: add 50% ethanol of 4~6 times amount, heating extraction 2 times, extraction time 1~1.5h in the Chinese herbal medicine residue after decocting;
(11) sucking filtration is merged: the liquid after precipitate with ethanol is merged sucking filtration with alcohol extract;
(12) recovered under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol to without alcohol taste;
(13) mixing: add Sargassum protein and the good volatile oil of emulsifying while hot in concentrated solution, stir;
(14) adjuvant is added: addition 0.10~the potassium sorbate of 0.15% and 1~the sweeting agent of 2%, add water stirring constant volume;
(15) stand: more than 48h will be stood under oral liquid semi-finished product room temperature;
(16) centrifugal: oral liquid semi-finished product 3000r/min is centrifuged 5~10min;
(17) constant volume subpackage: oral liquid constant volume, subpackage after being centrifuged i.e. obtain oral liquid finished product.
A kind of defying age herbal health care oral liquid, it is characterised in that what described sweeting agent was selected is the mixture of one or more in xylitol, oligomeric isomaltose, Mel.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107007690A (en) * | 2017-03-24 | 2017-08-04 | 北海市宝珠林海洋科技有限公司 | A kind of anti-aging pearl oral liquid and preparation method thereof |
CN107927312A (en) * | 2017-11-22 | 2018-04-20 | 渤海大学 | A kind of preparation method of heat-clearing disperse accumulation dried ice cream mix |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105055648A (en) * | 2015-07-22 | 2015-11-18 | 青岛浩大海洋保健食品有限公司 | Anti-aging Chinese herbal medicinal health oral liquid containing shark cartilage powder and preparation method of oral liquid |
CN105146618A (en) * | 2015-07-31 | 2015-12-16 | 潍坊友容实业有限公司 | Suaeda salsa beverage |
CN105477369A (en) * | 2015-12-21 | 2016-04-13 | 青岛浩大海洋保健食品有限公司 | Anti-aging Chinese herbal medicinal health oral liquid containing seaweed protein and preparation method of anti-aging Chinese herbal medicinal health oral liquid |
-
2016
- 2016-06-27 CN CN201610477436.9A patent/CN105998732A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105055648A (en) * | 2015-07-22 | 2015-11-18 | 青岛浩大海洋保健食品有限公司 | Anti-aging Chinese herbal medicinal health oral liquid containing shark cartilage powder and preparation method of oral liquid |
CN105146618A (en) * | 2015-07-31 | 2015-12-16 | 潍坊友容实业有限公司 | Suaeda salsa beverage |
CN105477369A (en) * | 2015-12-21 | 2016-04-13 | 青岛浩大海洋保健食品有限公司 | Anti-aging Chinese herbal medicinal health oral liquid containing seaweed protein and preparation method of anti-aging Chinese herbal medicinal health oral liquid |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107007690A (en) * | 2017-03-24 | 2017-08-04 | 北海市宝珠林海洋科技有限公司 | A kind of anti-aging pearl oral liquid and preparation method thereof |
CN107927312A (en) * | 2017-11-22 | 2018-04-20 | 渤海大学 | A kind of preparation method of heat-clearing disperse accumulation dried ice cream mix |
CN107927312B (en) * | 2017-11-22 | 2020-10-30 | 上海宏海食品有限公司 | Preparation method of ice cream powder |
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