CN104961674B - 用于合成依托考昔的对照品的制备方法 - Google Patents
用于合成依托考昔的对照品的制备方法 Download PDFInfo
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- CN104961674B CN104961674B CN201510437924.2A CN201510437924A CN104961674B CN 104961674 B CN104961674 B CN 104961674B CN 201510437924 A CN201510437924 A CN 201510437924A CN 104961674 B CN104961674 B CN 104961674B
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- CN
- China
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- etoricoxib
- compound
- method described
- highly basic
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- ZCWYTDUBAJRUHF-UHFFFAOYSA-N CN(C)/C=C(\C=[N+](C)C)/Cl Chemical compound CN(C)/C=C(\C=[N+](C)C)/Cl ZCWYTDUBAJRUHF-UHFFFAOYSA-N 0.000 description 1
- NSEGTYILFLYWFO-UHFFFAOYSA-N Cc(cc1)ncc1C(Cc(cc1)ccc1S(CC(c1ccc(C)nc1)=O)(=O)=O)=O Chemical compound Cc(cc1)ncc1C(Cc(cc1)ccc1S(CC(c1ccc(C)nc1)=O)(=O)=O)=O NSEGTYILFLYWFO-UHFFFAOYSA-N 0.000 description 1
- YEJWOYZOFJOOMI-UHFFFAOYSA-N Cc(nc1)ccc1C(CS(c(cc1)ccc1-c1cc(Cl)cnc1-c1cnc(C)cc1)(=O)=O)=O Chemical compound Cc(nc1)ccc1C(CS(c(cc1)ccc1-c1cc(Cl)cnc1-c1cnc(C)cc1)(=O)=O)=O YEJWOYZOFJOOMI-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510437924.2A CN104961674B (zh) | 2015-07-23 | 2015-07-23 | 用于合成依托考昔的对照品的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201510437924.2A CN104961674B (zh) | 2015-07-23 | 2015-07-23 | 用于合成依托考昔的对照品的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN104961674A CN104961674A (zh) | 2015-10-07 |
CN104961674B true CN104961674B (zh) | 2018-08-17 |
Family
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Family Applications (1)
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CN201510437924.2A Active CN104961674B (zh) | 2015-07-23 | 2015-07-23 | 用于合成依托考昔的对照品的制备方法 |
Country Status (1)
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CN (1) | CN104961674B (zh) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1681763A (zh) * | 2002-07-27 | 2005-10-12 | 阿斯特拉曾尼卡有限公司 | 化合物 |
CN102898357A (zh) * | 2011-07-29 | 2013-01-30 | 意大利合成制造有限公司 | 用于制备依托考昔的中间体1-(6-甲基吡啶-3-基)-2-[4-(甲磺酰基)苯基]乙酮的新方法 |
-
2015
- 2015-07-23 CN CN201510437924.2A patent/CN104961674B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1681763A (zh) * | 2002-07-27 | 2005-10-12 | 阿斯特拉曾尼卡有限公司 | 化合物 |
CN102898357A (zh) * | 2011-07-29 | 2013-01-30 | 意大利合成制造有限公司 | 用于制备依托考昔的中间体1-(6-甲基吡啶-3-基)-2-[4-(甲磺酰基)苯基]乙酮的新方法 |
Also Published As
Publication number | Publication date |
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CN104961674A (zh) | 2015-10-07 |
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Effective date of registration: 20201216 Address after: 570316 No. A-8, national high tech Industrial Development Zone, Haikou City, Hainan Province Patentee after: HAINAN DOCTOR PHARMACEUTICAL Co.,Ltd. Address before: 410205 19 Lu Tian Lu, hi tech Development Zone, Changsha, Hunan Patentee before: JIANGSU FANGSHENG PHARMACEUTICAL Co.,Ltd. |
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Effective date of registration: 20210608 Address after: No. 206, Kaiyuan Avenue, Science City, Guangzhou Economic and Technological Development Zone, Guangdong 510000 Patentee after: GUANGDONG JIDA GENETIC MEDICINE ENGINEERING RESEARCH CENTER Co.,Ltd. Address before: 570316 No. A-8, national high tech Industrial Development Zone, Haikou City, Hainan Province Patentee before: HAINAN DOCTOR PHARMACEUTICAL Co.,Ltd. |