CN104921005A - Garlic oil nanometer-scale microemulsion liquid and preparation method thereof - Google Patents
Garlic oil nanometer-scale microemulsion liquid and preparation method thereof Download PDFInfo
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- CN104921005A CN104921005A CN201510123170.3A CN201510123170A CN104921005A CN 104921005 A CN104921005 A CN 104921005A CN 201510123170 A CN201510123170 A CN 201510123170A CN 104921005 A CN104921005 A CN 104921005A
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Abstract
The present invention relates to a garlic oil nanometer-scale microemulsion liquid and a preparation method thereof. The garlic oil nanometer-scale microemulsion liquid comprises the following components (in mass percentage): surfactant 6%-65%, auxiliary surfactant 2%-30%, garlic oil 2%-13%, vegetable oil 0%-80%, and water 0-85%. Furthermore, the present invention also relates to a garlic oil nanometer-scale microemulsion liquid preparation method which includes the following steps: at room temperature, the garlic oil and the vegetable oil are mixed into mixture oil phase, and then the surfactant and auxiliary surfactant are added and mixed, and mixed in a swirl manner by slowly stirring, water is added into the system under the slowing stirring condition until the mutation of viscosity, and thus the clear and transparent garlic oil nanometer-scale microemulsion liquid is obtained. The garlic oil nanometer-scale microemulsion liquid can be used in the fields of food, health-care food, medicines and cosmetic, and the application scope of the fat-soluble garlic oil is extended.
Description
Technical field
The invention belongs to food processing field of nanometer technology, be specifically related to microemulsion of a kind of Nano grade and preparation method thereof, nanoscale microemulsion particularly relating to a kind of garlic oil and preparation method thereof.
Background technology
The laudatory title that garlic has " natural spectrum antibiotic ", containing 20 various active components in the garlic oil extracted, comprises alliin, 4,5,9-trithiadodeca-1,6,11-triene 9-oxide, adenosine, cholinomimetic etc. from garlic.The health-care efficacies such as garlic oil has antibacterial, hypotensive, reducing blood lipid, prevents and treats atherosclerotic, reduces blood sugar, anti-oxidant, antitumor, are with a wide range of applications in fields such as food, health food, medicine, cosmetics.But garlic oil itself is difficult to water-soluble, and bad dispersibility in aqueous, bioavilability is low, and has stronger volatility, makes it apply and is very limited.
Microemulsion is the transparent or translucent homogeneous system of the Thermodynamically stable, the outward appearance that are made up of surfactant, cosurfactant, oil phase and aqueous phase etc.The Dispersed Phase Size of microemulsion is little and even, usually between 1 ~ 100nm, and has good stability and dispersing characteristic.And the comparatively large and skewness of the particle diameter of simple emulsion, be usually greater than 100nm.Micro emulsion has caused the concern of medicament research and development person as the carrier of medicine, in recent years, food-processing industry also demonstrates huge application potential and Development volue gradually.
Garlic oil commercially available mostly at present is capsule embedding, because of its liposoluble characteristic, be only applicable in oil-soluble product, and the application in the product taking water as solvent is restricted.Therefore, the application of garlic oil be expanded, need to take technological means to be prepared into by garlic oil and be suitable for oil for solvent and water be the product of solvent, to improve the dissolubility of garlic oil, dispersiveness and bioavilability.Ability micro-emulsion technology prepares the Water-In-Oil of garlic oil and oil-in-water type Nano grade microemulsion is conducive to strengthening the solubility of garlic oil in grease and the aqueous solution.
CN1172598C disclose utilize galic essential oil and sorbierite T80 mixed with water in a heated condition and carry out stirring and emulsifying, make galic essential oil sterilizing pesticide emulsion, galic essential oil prepared by this invention is emulsion, particle diameter is larger, not clear, and be the state of thermodynamic instability, if to there is to condense and then occur being separated of aqueous phase and oil phase between emulsion through depositing for a long time, the organoleptic attribute in actual application can be affected.Allicin is added auxiliary material and makes garlic element fat emulsion by CN1579375A, but need in this technical process to utilize the even breast of high pressure homogenizer, energy consumption is comparatively large, and the product obtained is opaque white " milky " drop, and particle diameter is micron level, after placing for a long time, also there will be the phenomenon of layering.Garlic element fat emulsion injection disclosed in CN101112360B, also be stirred by homogenizer, then just obtain garlic Fat Emulsion by the technique of high pressure dispersing emulsification machine high energy consumption, the emulsion average grain diameter prepared is larger, for 200nm, just unstable after long-time placement.CN102727727A discloses a kind of oil-in-water type nitro sodium and garlic oil nanoemulsion antihypertensive drug, average grain diameter is 32.9nm, this invention only relates to the application at field of medicaments of oil-in-water type garlic oil and medicine mixing nanoemulsion, the not mentioned microemulsion medicine preparing garlic oil water-in-oil type.
Summary of the invention
For the deficiency that present prior art exists and defect, the object of the present invention is to provide a kind of nanoscale microemulsion of the garlic oil that may be used in oil-soluble or water-soluble products, improve the dissolubility of garlic oil, dispersiveness and bioavilability.
The technical scheme realizing foregoing invention object is: nanoscale microemulsion of a kind of garlic oil and preparation method thereof, it is characterized in that, the nanoscale microemulsion of described garlic oil consists of the following composition (by percentage to the quality): surfactant 6% ~ 65%, cosurfactant 2% ~ 30%, garlic oil 2% ~ 13%, vegetable oil 0% ~ 80%, water 0 ~ 85%.
Technique scheme is improved further, by percentage to the quality, consisting of of the nanoscale microemulsion of described garlic oil: surfactant 30% ~ 60%, cosurfactant 10% ~ 29%, garlic oil 4% ~ 13%, vegetable oil 0% ~ 60%.
According to said ratio, the nanoscale microemulsion that can obtain garlic oil is water-in-oil type.
Technique scheme is improved further, by percentage to the quality, consisting of of the nanoscale microemulsion of described garlic oil:: surfactant 8% ~ 60%, cosurfactant 3% ~ 18%, garlic oil 2% ~ 8%, vegetable oil 0% ~ 70%, water 5% ~ 80%.
According to said ratio, the nanoscale microemulsion that can obtain garlic oil is oil-in-water type.
Described surfactant is at least one in Tween-40, polyoxyethylene sorbitan monostearate, Tween-80, sorbitanmonolaureate or sucrose fatty ester.
Improve further technique scheme, described surfactant is Tween-80 or sorbitanmonolaureate.
Improve further technique scheme, described cosurfactant is ethanol.
Improve further technique scheme, described vegetable oil is rapeseed oil.
Water described in above-mentioned batching is pure water.
Present invention also offers the nanoscale microemulsion preparation method of described garlic oil, comprise the following steps:
(1) under room temperature, by garlic oil and vegetable oil composition mixture oil phase, then under the condition slowly stirred, surfactant and cosurfactant mixing is added wherein, and whirlpool mixing;
(2) under room temperature, under the condition slowly stirred, in above-mentioned steps (1) mixture system, water is added, until until viscosity sudden change, obtain the garlic oil nanoscale microemulsion of clear.
Compared with prior art, advantage of the present invention and beneficial effect are:
1, the present invention passes through the ratio of reasonably option table surface-active agent, cosurfactant, vegetable oil and garlic oil, the garlic oil nanoscale microemulsion even particle size distribution of preparation, system clear, good stability, room temperature is placed and is not found lamination, and average grain diameter is 13.2nm.
2, input energy in preparation process less, preparation method is simple, and cost of manufacture is lower, has expanded the range of application of fat-soluble garlic oil.
Detailed description of the invention
The present invention's the following example is described, but does not limit the scope of the invention.
Embodiment 1
Under room temperature, by weight by 1.00g garlic oil and the mixing of 0g rapeseed oil, then under the condition slowly stirred, after adding 6.00g sorbitanmonolaureate and 3.00g ethanol wherein, whirlpool mixes.Then, under the condition slowly stirred, in mixture system, add 0.66g water, until viscosity sudden change, till obtaining the liquid of clear.
Garlic oil nanoscale microemulsion outward appearance clear prepared by the present invention is water in oil microemulsion.Further, stability analysis is carried out to the garlic oil nanoscale microemulsion product of the present embodiment: microemulsion is placed in the phenomenon that being separated does not appear in centrifugal treating 20min under 5000g; Room temperature preservation does not occur significantly to be separated for 3 months yet, illustrates that it has good stability.
Embodiment 2
Under room temperature, by weight by 1.00g garlic oil and the mixing of 1.00g rapeseed oil, then under the condition slowly stirred, after adding 5.33g sorbitanmonolaureate and 2.67g ethanol wherein, whirlpool mixes.Then, under the condition slowly stirred, in mixture system, add 0.63g water, until viscosity sudden change, till obtaining the liquid of clear.
Garlic oil nanoscale microemulsion outward appearance clear prepared by the present invention is water in oil microemulsion.Further, stability analysis is carried out to the garlic oil nanoscale microemulsion product of the present embodiment: microemulsion is placed in the phenomenon that being separated does not appear in centrifugal treating 20min under 5000g; Room temperature preservation does not occur significantly to be separated for 3 months yet, illustrates that it has good stability.
Embodiment 3
Under room temperature, by weight by 1.00g garlic oil and the mixing of 0g rapeseed oil, then under the condition slowly stirred, after adding 6.75g Tween-80 and 2.25g ethanol wherein, whirlpool mixes.Then, under the condition slowly stirred, in mixture system, add 20.08g water, until viscosity sudden change, till obtaining the liquid of clear.
Garlic oil nanoscale microemulsion outward appearance clear prepared by the present invention is oil-in-water microemulsion.Further, stability analysis is carried out to the garlic oil nanoscale microemulsion product of the present embodiment: microemulsion is placed in the phenomenon that being separated does not appear in centrifugal treating 20min under 5000g; Room temperature preservation does not occur significantly to be separated for 3 months yet, illustrates that it has good stability.
Embodiment 4
Under room temperature, by weight by 1.10g garlic oil and the mixing of 0.90g rapeseed oil, then under the condition slowly stirred, after adding 6.00g Tween-80 and 2.00g ethanol wherein, whirlpool mixes.Then, under the condition slowly stirred, in mixture system, add 24.75g water, until viscosity sudden change, till obtaining the liquid of clear.
Garlic oil nanoscale microemulsion outward appearance clear prepared by the present invention is oil-in-water microemulsion.The microemulsion average grain diameter of preparation is 13.2 nm.Further, stability analysis is carried out to the garlic oil nanoscale microemulsion product of the present embodiment: microemulsion is placed in the phenomenon that being separated does not appear in centrifugal treating 20min under 5000g; Room temperature preservation does not occur significantly to be separated for 3 months yet, illustrates that it has good stability.
Embodiment 5
Under room temperature, by weight by 0.90g garlic oil and the mixing of 0.10g rapeseed oil, then under the condition slowly stirred, after adding 7.20g Tween-80 and 1.80g ethanol wherein, whirlpool mixes.Then, under the condition slowly stirred, in mixture system, add 18.01g water, until viscosity sudden change, till obtaining the liquid of clear.
Garlic oil nanoscale microemulsion outward appearance clear prepared by the present invention is oil-in-water microemulsion.Further, stability analysis is carried out to the garlic oil nanoscale microemulsion product of the present embodiment: microemulsion is placed in the phenomenon that being separated does not appear in centrifugal treating 20min under 5000g; Room temperature preservation does not occur significantly to be separated for 3 months yet, illustrates that it has good stability.
Claims (8)
1. the nanoscale microemulsion of a garlic oil, it is characterized in that, the nanoscale microemulsion of described garlic oil consists of the following composition (by percentage to the quality): surfactant 6% ~ 65%, cosurfactant 2% ~ 30%, garlic oil 2% ~ 13%, vegetable oil 0% ~ 80%, water 0 ~ 85%.
2. according to the nanoscale microemulsion of a kind of garlic oil according to claim 1, it is characterized in that, the nanoscale microemulsion of described garlic oil consists of the following composition (by percentage to the quality): surfactant 30% ~ 60%, cosurfactant 10% ~ 29%, garlic oil 4% ~ 13%, vegetable oil 0% ~ 60%.
3. according to the nanoscale microemulsion of a kind of garlic oil according to claim 1, it is characterized in that, the nanoscale microemulsion of described garlic oil consists of the following composition (by percentage to the quality): surfactant 8% ~ 60%, cosurfactant 3% ~ 18%, garlic oil 2% ~ 8%, vegetable oil 0% ~ 70%, water 5% ~ 80%.
4. according to the nanoscale microemulsion of a kind of garlic oil according to claim 1, it is characterized in that, described surfactant is at least one in Tween-40, polyoxyethylene sorbitan monostearate, Tween-80, sorbitanmonolaureate or sucrose fatty ester.
5. according to the nanoscale microemulsion of a kind of garlic oil according to claim 1, it is characterized in that, described cosurfactant is at least one in ethanol, glycerine or n-butanol.
6. according to the nanoscale microemulsion of a kind of garlic oil according to claim 1, it is characterized in that, described vegetable oil is at least one in soybean oil, rapeseed oil or sunflower oil.
7. according to the nanoscale microemulsion of a kind of garlic oil according to claim 1, it is characterized in that, described garlic oil nanoscale microemulsion is the one in water-in-oil type or oil-in-water type.
8. a preparation method for the nanoscale microemulsion of garlic oil, is characterized in that, the preparation method of described garlic oil nanoscale microemulsion, comprises the following steps:
(1) under room temperature, by garlic oil and vegetable oil composition mixture oil phase, then under the condition slowly stirred, surfactant and cosurfactant mixing is added wherein, and whirlpool mixing;
(2) under room temperature, under the condition slowly stirred, in above-mentioned steps (1) mixture system, water is added, until until viscosity sudden change, obtain the garlic oil nanoscale microemulsion of clear.
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Cited By (10)
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| CN106333353A (en) * | 2016-08-25 | 2017-01-18 | 江南大学 | High-stability mustard oil nanometer emulsion and preparation method thereof |
| CN106720196A (en) * | 2016-12-13 | 2017-05-31 | 江南大学 | A kind of preparation method for pickling fresh-keeping liquid and pickle fresh-keeping liquid and applied with it |
| CN107183221A (en) * | 2017-04-28 | 2017-09-22 | 蚌埠市九华油脂有限公司 | A kind of garlic oil for being used to cook |
| CN107684529A (en) * | 2017-08-21 | 2018-02-13 | 上海相宜本草化妆品股份有限公司 | A kind of microemulsified facial mask liquid and preparation method thereof |
| CN109122817A (en) * | 2018-11-01 | 2019-01-04 | 大连工业大学 | A kind of fish composite micro-emulsion liquid type antistaling agent and the preparation method and application thereof |
| CN109122904A (en) * | 2018-08-09 | 2019-01-04 | 天津大学 | A kind of preparation method of palm oil Microemulsions For Use |
| CN109380700A (en) * | 2018-11-08 | 2019-02-26 | 天津科技大学 | A kind of galic essential oil microcapsules and preparation method thereof |
| CN111053112A (en) * | 2019-11-14 | 2020-04-24 | 北京农业智能装备技术研究中心 | Navel orange penicilliosis inhibitor and preparation method and preparation condition determination method thereof |
| CN113908082A (en) * | 2021-10-14 | 2022-01-11 | 上海应用技术大学 | Preparation method of soybean oil microemulsion capable of being infinitely diluted |
| CN114404325A (en) * | 2022-01-13 | 2022-04-29 | 上海应用技术大学 | Oil-in-water rapeseed oil microemulsion capable of being infinitely diluted, and preparation method and application thereof |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106333353A (en) * | 2016-08-25 | 2017-01-18 | 江南大学 | High-stability mustard oil nanometer emulsion and preparation method thereof |
| CN106720196A (en) * | 2016-12-13 | 2017-05-31 | 江南大学 | A kind of preparation method for pickling fresh-keeping liquid and pickle fresh-keeping liquid and applied with it |
| CN107183221A (en) * | 2017-04-28 | 2017-09-22 | 蚌埠市九华油脂有限公司 | A kind of garlic oil for being used to cook |
| CN107684529A (en) * | 2017-08-21 | 2018-02-13 | 上海相宜本草化妆品股份有限公司 | A kind of microemulsified facial mask liquid and preparation method thereof |
| CN109122904A (en) * | 2018-08-09 | 2019-01-04 | 天津大学 | A kind of preparation method of palm oil Microemulsions For Use |
| CN109122817A (en) * | 2018-11-01 | 2019-01-04 | 大连工业大学 | A kind of fish composite micro-emulsion liquid type antistaling agent and the preparation method and application thereof |
| CN109380700A (en) * | 2018-11-08 | 2019-02-26 | 天津科技大学 | A kind of galic essential oil microcapsules and preparation method thereof |
| CN111053112A (en) * | 2019-11-14 | 2020-04-24 | 北京农业智能装备技术研究中心 | Navel orange penicilliosis inhibitor and preparation method and preparation condition determination method thereof |
| CN113908082A (en) * | 2021-10-14 | 2022-01-11 | 上海应用技术大学 | Preparation method of soybean oil microemulsion capable of being infinitely diluted |
| CN114404325A (en) * | 2022-01-13 | 2022-04-29 | 上海应用技术大学 | Oil-in-water rapeseed oil microemulsion capable of being infinitely diluted, and preparation method and application thereof |
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