CN104906251B - A kind of Traditional Chinese medicine compound composition with treatment diabetes effect and preparation method and application - Google Patents
A kind of Traditional Chinese medicine compound composition with treatment diabetes effect and preparation method and application Download PDFInfo
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Abstract
The invention discloses a kind of Traditional Chinese medicine compound composition with treatment diabetes effect and preparation method and application, it is made by giving birth to 30 90 parts of the Radix Astragali, 20 60 parts of the dried rhizome of rehmannia, 10 30 parts of Fructus Corni, 10 30 parts of the root bark of tree peony, 20 60 parts of the red sage root, 10 30 parts of sunset abelmoschus flower.The present invention carries out proportioning prescription using the theory of diagnosis and treatment, clinical trial results show, Traditional Chinese medicine compound composition provided by the invention has the comprehensive function of too many levels, Mutiple Targets, the carbohydrate metabolism disturbance of diabetic can be corrected, with reduction blood glucose and blood fat, improve insulin resistance, kidney trouble and its terminal nerve inflammatory disease are closed available for preventing and treating hyperlipidemia with diabetes and diabetes, and clinical trial results show that Chinese medicine compound prescription long-term use provided by the invention has no adverse reaction, medication is safer.
Description
Technical field
The present invention relates to a kind of Chinese medicine compound prescription, and in particular to a kind of Traditional Chinese medicine compound composition with treatment diabetes effect
And preparation method and application.
Background technology
Diabetes are a kind of global common diseases and frequently-occurring disease, it has also become the after tumour and angiocardiopathy the 3rd
Big disease.Diabetes clinically often merge Other diseases, as diabetes merge nephrosis and diabetes and hyperlipidemia complications disease.Diabetes
On the one hand it is the kidney qi loss because the deficiency of Yin is scorching to merge nephrosis, precise and tiny to lose admittedly；On the other hand it is the bright blood of heat, forms hemostasis, stasis blocking
Kidney network, entire mistake department is opened, is let out under precise and tiny, can cause diabetes kidney damage, seriously affects the quality of life of people.
The medicine for the treatment of diabetes is more at present, the Western medicine clinically used, though having the effect of certain, majority is present
Larger adverse reaction, as occurred being rebounded after being discontinued, patient's hepatorenal damage, striated muscle melt the side effects such as disease, cure the symptoms, not the disease,
And traditional Chinese medicine has its unique advantage in terms of diabetes are treated, TCM prevention and cure diabetes prescription is numerous, and curative effect is more lasting, and
Majority is partial to folk prescription, proved recipe more without obvious toxic-side effects, but currently for the Chinese medicine of diabetes, lacks the clinical medicine of system perfecting
Effect research, and Chinese prescription is according to having nothing in common with each other, rules for the treatment of disunity, therefore base oneself upon traditional Chinese medicine, according to the pathogenesis of diabetes,
Actively find and make great efforts to explore and treat this sick high effect nontoxic, medicine easy to carry, have great importance.
The content of the invention
Goal of the invention：, can be obvious present invention aims to solve the deficiencies of the prior art, and provides a kind of one kind proportioning is scientific and reasonable
Diabetes and its blood glucose of complication nephrotic are reduced, improves renal function, and blood fat can be reduced well, improves patient clinical
The Chinese medicine compound prescription of symptom；Another object of the present invention is to provide preparation method and its application of the Traditional Chinese medicine compound composition.
Technical scheme：In order to realize the above object the technical scheme that the present invention takes is：
A kind of Traditional Chinese medicine compound composition with treatment diabetes effect, it is made up of the bulk drug of following parts by weight：
Raw Radix Astragali 30-90 parts, dried rhizome of rehmannia 20-60 parts, Fructus Corni 10-30 parts, root bark of tree peony 10-30 parts, red sage root 20-60 parts, sunset abelmoschus flower 10-30
Part.
As a preferred scheme, the above-described Traditional Chinese medicine compound composition with treatment diabetes effect, it is under
The bulk drug of row parts by weight is made：Raw Radix Astragali 30-60 parts, dried rhizome of rehmannia 20-40 parts, Fructus Corni 10-20 parts, root bark of tree peony 10-20 parts, pellet
Join 20-40 parts, sunset abelmoschus flower 10-20 parts.
Preferably, the above-described Traditional Chinese medicine compound composition with treatment diabetes effect, it is by following heavy
The bulk drug of amount number is made：Raw 30 parts of the Radix Astragali, 20 parts of the dried rhizome of rehmannia, 10 parts of Fructus Corni, 10 parts of the root bark of tree peony, 20 parts of the red sage root, sunset abelmoschus flower
10 parts.
The present invention is screened, the present invention is preferably according to traditional Chinese medical theory and Pathogenesis of Diabetic Nephropathy by many experiments
Obtained Chinese medicine compound prescription, it is made up of the raw Radix Astragali, the dried rhizome of rehmannia, dogwood fruit, the root bark of tree peony, the red sage root, sunset abelmoschus flower.Wherein, the Radix Astragali is sweet, and property is micro-
Temperature；Return lung, spleen, liver and kidney channel；《Sheng Nong's herbal classic》Record Radix Astragali energy " benefit husband is deficient, and the exhaustion or lesion of the five internal organs is thin thin, quenches the thirst, and stomachache lets out dysentery,
QI invigorating, Li Yin gas." be harmonious with the interpretation of the cause, onset and process of an illness of with the passing of time deficiency of both qi and yin of quenching one's thirst.Modern pharmacological research result shows that it is improved immune work(
Can, anti-oxidant, protection cardiovascular and cerebrovascular, kidney etc., reducing blood lipid, effect that is hypoglycemic, eliminating diabetes albuminuria, are for monarch drug in a prescription.
The dried rhizome of rehmannia is sweet, cold in nature.The thoughts of returning home, liver, kidney channel.Function clearing heat and cooling blood, yin-nourishing, promotes the production of body fluid.For the deep red polydipsia of pyreticosis tongue, yin asthenia generating intrinsic heat,
Hectic fever due to yin labor heat, Heat Diabetes ...《Mingyi Bielu》：" Great Cold, it is sweet, put down, it is nontoxic.Solve all heat, blood-breaking, the tonneau moon water close absolutely.
Not dredging water passages, thin trusted subordinate is smash, can dispersing blood stasis blood.How hot patient is empty and, adds and uses it." dogwood fruit is sour, tepor is mild-natured.Function is mended
Liver kidney, puckery vital essence, Gu collapse.Cure mainly：Control soreness of waist and knee joint, dizziness, tinnitus, impotence, seminal emission, frequent urination etc..《Mingyi Bielu》：
" middle benefit gas, lower gas, perspire, Qiang Yin, strengthening the essence, five viscera settling, lead to nine orifices, only small facility, improving eyesight, strength ".Pharmacological research shows the dried rhizome of rehmannia
Immune regulation, anti-inflammatory, sterilization, hypoglycemic, anti-ageing pharmacological action of waiting for a long time are respectively provided with Fructus Corni, is combined into ministerial drug, the principal drug assistance Radix Astragali
The power of boosting qi and nourishing yin.Red sage root bitter, is slightly cold.The thoughts of returning home, pericardium, Liver Channel.It is inducing meastruation to relieve menalgia with promoting blood circulation, relieving restlessness that clears away heart-fire, cool blood
The effect of carbuncle that disappears is minister, and the pharmacological research display red sage root has protection vascular endothelial cell, improves microcirculation, suppresses and releasing blood is small
Plate is assembled, and improves the effect such as body's hypoxia tolerance.It is root bark of tree peony bitter, pungent, it is slightly cold.The thoughts of returning home, liver and kidney channel.Work(is in clearing heat and cooling blood, work
Blood dissipates the stasis of blood.Pharmacological research shows that it mainly resists myocardial ischemia, hypotensive, hypoglycemic, reducing blood lipid, improves hemorheology, be anti-
Oxidation, antibacterial anti-inflammatory etc..Sunset abelmoschus flower is sweet, cold in nature.Return kidney, bladder warp.With eliminating dampness and heat, the effect of subdhing swelling and detoxicating, with
The scorching card of the diabetic nephropathy deficiency of Yin is harmonious.Pharmacological research, which shows that it has, to be improved renal function, hypoglycemic, promotes the pharmacology such as angiogenesis
Effect.Clinically it is mainly used in treating acute and chronic nephritis, diabetic nephropathy.The red sage root, the root bark of tree peony, Althaea roseal share, and play heat-clearing work altogether
Blood, the effect for dredging collateral of subsiding a swelling, the interpretation of the cause, onset and process of an illness hindered with the stagnant heat numbness of diabetic nephropathy are more in step with, and are for adjutant.Our through-supplementation,
Without helping heresy, eliminating evil is not hindered just for righting, and with reference to modern pharmacology, all medicines are respectively provided with preferable hypoglycemic and protect kidney function effect, and safe nothing
Poison, actually treat deficiency of both qi and yin and accompany stagnant heat patients with type Ⅰ DM first choice.
A kind of medicine with treatment diabetic nephropathy effect, can by the extract of Traditional Chinese medicine compound composition and pharmaceutically connect
The carrier received is prepared into the medicine of oral liquid, granule, capsule, tablet, powder-injection, dripping pill, soft capsule or parenteral solution formulation.
The Traditional Chinese medicine compound composition with treatment diabetes effect of the present invention, by each raw extract and pharmaceutically
Acceptable carrier is prepared into oral liquid, granule, capsule, tablet, powder-injection, dripping pill, soft capsule or parenteral solution formulation
Medicine.
When the extract of each raw material of Chinese medicine compound prescription provided by the invention is made into oral liquid, the extract of each raw material is added
Distilled water dissolves, and filtering, adjusts pH value, oral liquid is made.
When the extract of each raw material of Chinese medicine compound prescription provided by the invention is made into tablet, each raw material and lactose or corn
Starch, it is necessary to when add magnesium stearate lubricant, be well mixed, tablet is made in whole grain, then tabletting.
When the extract of Chinese medicine compound prescription provided by the invention is made capsule the extract and carrier lactose of each raw material or
Cornstarch is well mixed, whole grain, then encapsulated that capsule is made.
When granule is made in the extract of each raw material of Chinese medicine compound prescription provided by the invention, the extract of each raw material and dilute
Agent lactose or cornstarch, well mixed, whole grain are released, it is dry, granule is made.
When powder-injection is made in the extract of each raw material of Chinese medicine compound prescription provided by the invention, the extract of each raw material is freezed
Dry, sterilization, powder-injection is made.
When parenteral solution is made in the extract of each raw material of Chinese medicine compound prescription provided by the invention, the extract of each raw material is taken to add
Then physiological saline solution adds activated carbon, stir, and 80 DEG C are heated 30 minutes, filtering, are adjusted pH value, are leaked with incipient fusion glass
Bucket or other filters are filtered to clear and bright, filling, parenteral solution are made within 30 minutes in 100 to 115 DEG C of sterilizings.
The preparation method of the medicine of the present invention that there is treatment diabetic nephropathy to act on, comprises the following steps：
(1) the raw Radix Astragali, the dried rhizome of rehmannia, Fructus Corni are taken in parts by weight, and the decocting for adding 8~10 times of amounts of medicinal material weight is boiled or flowed back
Extraction 2~3 times, 1~2 hour every time, merge extract solution, be concentrated to give medicinal extract, it is standby；
(2) root bark of tree peony, the red sage root, sunset abelmoschus flower is taken to use alcohol extracting method in parts by weight, with the ethanol of 8~10 times of amounts of medicinal material weight
Refluxing extraction 2~3 times, 1~2 hour every time, merge extract solution, reclaim ethanol, be concentrated to give medicinal extract, it is standby；
(3) medicinal extract that step (1) obtains and the medicinal extract that step (2) obtains is taken to be prepared into mouth with pharmaceutically acceptable carrier
Take the medicine of liquid, granule, capsule, tablet, powder-injection, dripping pill, soft capsule or parenteral solution formulation.
The Traditional Chinese medicine compound composition with treatment diabetes effect of the present invention is in treatment diabetes medicament is prepared
Application.
The Traditional Chinese medicine compound composition with treatment diabetes effect of the present invention is preparing treatment diabetic nephropathy medicine
Application in thing.
It is of the present invention that there is the Traditional Chinese medicine compound composition for treating diabetes effect to merge height in preparation preventing and treating diabetes
Application in piarhemia disease drug.
The Traditional Chinese medicine compound composition with treatment diabetes effect of the present invention merges end in preparation preventing and treating diabetes
Application in tip neuritis medicine.
Beneficial effect：Traditional Chinese medical theory of the invention according to diagnosis and treatment, according to the morbidity machine of diabetes and its complication
Reason carry out Chinese prescription screening, there is provided Chinese medicine compound prescription proportioning it is scientific and reasonable, medication is rigorous, test result indicates that, the present invention carries
The Traditional Chinese medicine compound composition of confession has good effect of lowering blood sugar, and also has reduction microdose urine protein, urine β 2- well
Microglobulin, blood Cr and blood BUN effects, have a good Renoprotective Effect, and test result indicates that, it is provided by the invention
Chinese medicine compound prescription also with well with anti-inflammatory efficacy, has good prophylactic-therapeutic effect to diabetes peripheral neuritis.And
Chinese medicine composition provided by the invention can also significantly reduce TC, TG, LDL-C of diabetic, have obvious reduction blood
The effect of fat.And Traditional Chinese medicine compound composition long-term use toxic side effect provided by the invention is small, and drug safety is reliable.
Embodiment
With reference to specific embodiment, the present invention is furture elucidated, it should be understood that these embodiments be merely to illustrate the present invention and
Limitation the scope of the present invention is not used in, after the present invention has been read, various of equal value shapes of the those skilled in the art to the present invention
The modification of formula falls within the application appended claims limited range.
Embodiment 1
1st, it is a kind of have treatment diabetes effect Traditional Chinese medicine compound composition, it by following parts by weight bulk drug system
Into：Raw Radix Astragali 30g, dried rhizome of rehmannia 20g, Fructus Corni 10g, root bark of tree peony 10g, red sage root 20g, sunset abelmoschus flower 10g.
2nd, the preparation method of the Traditional Chinese medicine compound composition of the present invention that there are treatment diabetes to act on, it includes following
Step：
(1) raw Radix Astragali 30g, dried rhizome of rehmannia 20g, Fructus Corni 10g are taken in parts by weight, and the decocting for adding 10 times of amounts of medicinal material weight is boiled
Extraction 3 times, 1 hour every time, merge extract solution, be concentrated to give medicinal extract, it is standby；
(2) root bark of tree peony 10g, red sage root 20g, sunset abelmoschus flower 10g are taken in parts by weight, with the alcohol reflux of 8 times of amounts of medicinal material weight
Extraction 2 times, 2 hours every time, merge extract solution, reclaim ethanol, be concentrated to give medicinal extract, it is standby；
(3) medicinal extract that step (1) obtains and the medicinal extract that step (2) obtains is taken to be mixed with carrier lactose or cornstarch
Even, whole grain is then encapsulated that capsule is made.(lot number：001)
Embodiment 2
1st, it is a kind of have treatment diabetes effect Traditional Chinese medicine compound composition, it by following parts by weight bulk drug system
Into：Raw Radix Astragali 90g, dried rhizome of rehmannia 60g, Fructus Corni 30g, root bark of tree peony 30g, red sage root 60g, sunset abelmoschus flower 30g.
2nd, the preparation method of the Traditional Chinese medicine compound composition of the present invention that there are treatment diabetes to act on, it includes following
Step：
(1) raw Radix Astragali 90g, dried rhizome of rehmannia 60g, Fructus Corni 30g are taken in parts by weight, add the water backflow of 8 times of amounts of medicinal material weight
Extraction 2 times, 2 hours every time, merge extract solution, be concentrated to give medicinal extract, it is standby；
(2) root bark of tree peony 30g, red sage root 60g, sunset abelmoschus flower 30g are taken in parts by weight, with the alcohol reflux of 10 times of amounts of medicinal material weight
Extraction 3 times, 1 hour every time, merge extract solution, reclaim ethanol, be concentrated to give medicinal extract, it is standby；
(3) medicinal extract that step (1) obtains and the medicinal extract that step (2) obtains are taken, adds distilled water to dissolve, is filtered, adjusts pH value,
Oral liquid is made.(lot number：002)
Embodiment 3
1st, it is a kind of have treatment diabetes effect Traditional Chinese medicine compound composition, it by following parts by weight bulk drug system
Into：Raw Radix Astragali 60g, dried rhizome of rehmannia 40g, Fructus Corni 20g, root bark of tree peony 20g, red sage root 40g, sunset abelmoschus flower 20g.
2nd, the preparation method of the Traditional Chinese medicine compound composition of the present invention that there are treatment diabetes to act on, it includes following
Step：
(1) raw Radix Astragali 60g, dried rhizome of rehmannia 40g, Fructus Corni 20g are taken in parts by weight, add the water backflow of 12 times of amounts of medicinal material weight
Extraction 2 times, 1 hour every time, merge extract solution, be concentrated to give medicinal extract, it is standby；
(2) root bark of tree peony 20g, red sage root 40g, sunset abelmoschus flower 20g are taken in parts by weight, with the alcohol reflux of 8 times of amounts of medicinal material weight
Extraction 2 times, 2 hours every time, merge extract solution, reclaim ethanol, be concentrated to give medicinal extract, it is standby；
(3) medicinal extract that step (1) obtains and the medicinal extract that step (2) obtains are taken, adds diluent cyclodextrin or cornstarch
It is well mixed, whole grain, dry, granule is made.(lot number：003)
Embodiment 4
The dry extract freeze-drying that the medicinal extract and step (2) that the step of Example 1 (1) obtains obtain, sterilization, is made powder pin
Agent.(lot number：004)
The clinical research of embodiment 5
One, case selections, packet and treatment
All cases be Nanjing Traditional Chinese Medicine Univ. affiliated hospital, Nanjing University of Traditional Chinese Medicine Chinese and Western combine clinic trouble
Person.It is the patient for making a definite diagnosis diabetes and its nephrosis.Doctor trained in Western medicine name diagnosis refers to《Practical clinical practice》The standard of 11st edition formulation.
Chinese medical discrimination is " deficiency of both qi and yin, stagnant heat hinder network " card.
Include case standard：(1) 45-70 year；(2) there are diabetes or diabetic nephropathy；(3) doctor trained in Western medicine name diagnosis mark is met
Accurate and Standards of Chinese Medical Syndrome Differentiation, through blood glucose and the kidney function test person of meeting.
Experiment packet：80 are randomly divided into Traditional Chinese medicine compound composition group 40 of the present invention, control group (Liuwei Dihuang granule
Group) 40.Primary condition is statistically analyzed, two groups of there was no significant difference (P>0.05).Dosage：This hair is taken by treatment group
The Traditional Chinese medicine compound composition that bright embodiment 1 is prepared, 2 times a day；Control group Liuwei Dihuang granule, 2 times a day.Treatment week
Phase is 30 days.
(1) two group of blood glucose compares
Table one：Influence of the medicine to blood glucose
* P ＜ 0.01, compared with before the treatment of corresponding control group；#P ＜ 0.01, controlled with corresponding Traditional Chinese medicine compound composition group
Before treating relatively；AP ＜ 0.01, compared with after the treatment of corresponding control group
By table one test result indicates that, two groups of fasting blood-glucoses before treatment, postprandial 2 hours blood glucose, glycosylated hemoglobin without
Significant difference (P ＞ 0.05)；Under two groups of fasting blood-glucoses, postprandial 2 hours blood glucose, glycosylated hemoglobins all occur substantially after treatment
Drop；Fasting blood-glucose, postprandial 2 hours blood glucose, glycosylated hemoglobins after Traditional Chinese medicine compound composition treatment wherein provided by the invention
It is obvious to reduce.As a result show that Chinese medicine composition provided by the invention has good hypoglycemic effect.
(2) two groups of renal functions compare
Table two：Influence of the medicine to renal function
* P ＜ 0.01, compared with before the treatment of corresponding control group；#P ＜ 0.01, controlled with corresponding Traditional Chinese medicine compound composition group
Before treating relatively；AP ＜ 0.01, compared with after the treatment of corresponding control group
Two groups of microdose urine proteins before treatment, Urine β2- microglobulin, blood Cr, there was no significant difference by blood BUN (P ＞ 0.05)；
Two groups of microdose urine proteins, Urine β2- microglobulin, blood Cr, blood BUN are decreased obviously after treatment；Wherein Chinese medicine compound prescription group
Microdose urine protein, Urine β2- microglobulin, blood Cr, blood BUN after the treatment of compound group is significantly lower than the value after control group treatment.
As a result show that Traditional Chinese medicine compound composition provided by the invention has protecting renal function effect, there is treatment diabetic nephropathy well
Effect.
(3) two groups of inflammatory factors compare
Table three：Influence of the medicine to inflammatory factor
* P ＜ 0.01, compared with before the treatment of corresponding control group；#P ＜ 0.01, controlled with corresponding Traditional Chinese medicine compound composition group
Before treating relatively；AP ＜ 0.01, compared with after the treatment of corresponding control group
There was no significant difference (P ＞ 0.05) by two groups of TNFa, IL-6 before treatment；Two groups of TNFa, IL-6 occur bright after treatment
It is aobvious to decline；TNFa, IL-6 wherein after the treatment of Traditional Chinese medicine compound composition group is less than the value after control group treatment.As a result this hair is shown
There is the Traditional Chinese medicine compound composition of bright offer good anti -inflammatory cytokine to act on, and have to diabetes peripheral neuritis good
Prophylactic-therapeutic effect.
(4) two groups of four items of blood lipid tests compare
Table four：Influence of the medicine to blood fat
* P ＜ 0.01, compared with before the treatment of corresponding control group；#P ＜ 0.01, controlled with corresponding Traditional Chinese medicine compound composition group
Before treating relatively；AP ＜ 0.01, compared with after the treatment of corresponding control group
There was no significant difference (P ＞ 0.05) by two groups of TC, TG, LDL-C, HDL-C before treatment；Control group TC, LDL-C after treatment
It is decreased obviously；Traditional Chinese medicine compound composition group TC, TG, LDL-C are decreased obviously after treatment；Wherein Traditional Chinese medicine compound composition
TC, TG, LDL-C after group treatment is less than the value after control group treatment.As a result show that Traditional Chinese medicine compound composition has drop well
Low blood fat.
The present invention carries out proportioning prescription using the theory of diagnosis and treatment, passes through above experimental result according to traditional Chinese medical theory
Show, Chinese medicine compound prescription provided by the invention has the comprehensive function of too many levels, Mutiple Targets, can correct the sugared generation of diabetic
Thank to disorder, having reduces blood glucose and blood fat, improves insulin resistance, available for preventing and treating hyperlipidemia with diabetes and diabetes
Kidney trouble and its terminal nerve inflammatory disease are closed, and clinical trial results show Chinese medicine compound prescription long-term use nothing provided by the invention
Adverse reaction, medication are safer.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (7)
1. it is a kind of have treatment diabetes effect Traditional Chinese medicine compound composition, it is characterised in that it by following parts by weight original
Material medicine is made：Raw 30 parts of the Radix Astragali, 20 parts of the dried rhizome of rehmannia, 10 parts of Fructus Corni, 10 parts of the root bark of tree peony, 20 parts of the red sage root, 10 parts of sunset abelmoschus flower.
2. a kind of medicine with treatment diabetes effect, it is characterised in that by the Traditional Chinese medicine compound composition described in claim 1
Extract and pharmaceutically acceptable carrier be prepared into oral liquid, granule, capsule, tablet, powder-injection, dripping pill, flexible glue
The medicine of capsule or parenteral solution formulation.
3. the preparation method of the medicine with treatment diabetes effect described in claim 2, it is characterised in that including following step
Suddenly：
(1) parts by weight as described in claim 1 take the raw Radix Astragali, the dried rhizome of rehmannia, Fructus Corni, add 8~10 times of amounts of medicinal material weight
Decocting is boiled or refluxing extraction 2~3 times, 1~2 hour every time, merges extract solution, is concentrated to give medicinal extract, standby；
(2) parts by weight as described in claim 1 take the root bark of tree peony, the red sage root, sunset abelmoschus flower, with the second of 8~10 times of amounts of medicinal material weight
Alcohol reflux extracts 2~3 times, 1~2 hour every time, merges extract solution, reclaims ethanol, be concentrated to give medicinal extract, standby；
(3) medicinal extract that step (1) obtains and the medicinal extract that step (2) obtains is taken to be prepared into orally with pharmaceutically acceptable carrier
Liquid, granule, capsule, tablet, powder-injection, dripping pill, the medicine of soft capsule or parenteral solution formulation.
4. there is the Traditional Chinese medicine compound composition for the treatment of diabetes effect in treatment diabetes medicament is prepared described in claim 1
Application.
5. the Traditional Chinese medicine compound composition with treatment diabetes effect described in claim 1 is preparing treatment diabetic nephropathy medicine
Application in thing.
6. the Traditional Chinese medicine compound composition that having described in claim 1 treats diabetes effect merges height in preparation preventing and treating diabetes
Application in piarhemia disease drug.
7. the Traditional Chinese medicine compound composition with treatment diabetes effect described in claim 1 merges end in preparation preventing and treating diabetes
Application in tip neuritis medicine.
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| CN108066650B (en) * | 2018-01-26 | 2020-08-04 | 江苏省中医院 | Traditional Chinese medicine compound composition with effect of treating metabolic syndrome and preparation method and application thereof |
| CN108159300B (en) * | 2018-01-26 | 2020-06-09 | 严士海 | Traditional Chinese medicine compound composition with function of treating hypertension complicated with diabetes and preparation method and application thereof |
| CN113908235B (en) * | 2021-12-02 | 2023-07-28 | 江苏省中医院 | Chinese herbal compound preparation for treating diabetic retinopathy and preparation method and application thereof |
| CN116808156A (en) * | 2023-05-15 | 2023-09-29 | 江苏省中医院 | Traditional Chinese medicine composition for preventing and treating atherosclerosis and application thereof |
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