CN104906251A - Traditional Chinese medicine compound combination with diabetes treating effect and preparation method and application thereof - Google Patents
Traditional Chinese medicine compound combination with diabetes treating effect and preparation method and application thereof Download PDFInfo
- Publication number
- CN104906251A CN104906251A CN201510405578.XA CN201510405578A CN104906251A CN 104906251 A CN104906251 A CN 104906251A CN 201510405578 A CN201510405578 A CN 201510405578A CN 104906251 A CN104906251 A CN 104906251A
- Authority
- CN
- China
- Prior art keywords
- diabetes
- chinese medicine
- traditional chinese
- treatment
- medicine compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine compound combination with the diabetes treating effect and a preparation method and application thereof. The traditional Chinese medicine compound combination is prepared from 30 to 90 parts of astragali radix, 20 to 60 parts of rhizome of rehmannia, 10 to 30 parts of dogwood, 10 to 30 parts of the root bark of the peony tree, 20 to 60 parts of the root of red-rooted salvia, and 10 to 30 parts of ambrette musk mallow. According to the traditional Chinese medicine compound combination, the preparation and prescription formulation are carried out according to the theory of syndrome differentiation and treatment; the clinical experiment result shows that the traditional Chinese medicine compound combination has multi-link and multi-target comprehensive effect, can treat disturbance of carbohydrate metabolism of patients with diabetes, has the effects of decreasing blood sugar and blood lipid, and improving insulin resistance, and can be used for preventing and treating diabetes with hyperlipidemia, diabetes with kidney disease, and terminal nerve inflammatory disease; the clinical experiment result shows that the traditional Chinese medicine compound combination is free of adverse reaction after long-term use, and safe to use.
Description
Technical field
The present invention relates to a kind of Chinese medicine compound, be specifically related to a kind of to there is Traditional Chinese medicine compound composition for the treatment of diabetes effect and preparation method thereof and application.
Background technology
Diabetes are a kind of global commonly encountered diseases and frequently-occurring disease, have become the third-largest disease after tumor and cardiovascular disease.Diabetes often merge Other diseases clinically, as diabetes merge nephropathy and diabetes and hyperlipidemia complications disease.It is because the deficiency of YIN is scorching on the one hand that diabetes merge nephropathy, kidney qi loss, and precise and tiny mistake is solid; Be the bright blood of heat on the other hand, form blood stasis, stasis blocking kidney network, opens entire mistake department, lets out under precise and tiny, all can cause diabetes kidney damage, badly influence the quality of life of people.
The medicine of current treatment diabetes is more, the Western medicine used clinically, though have certain curative effect, but most exist larger untoward reaction, rebound after there is drug withdrawal, patient's hepatorenal damage, striped muscle melts the side effect such as disease, cure the symptoms, not the disease, and Chinese medicine has the advantage of its uniqueness in treatment diabetes, TCM prevention and cure diabetes side medicine is numerous, curative effect is more lasting, and it is most without obvious toxic-side effects, but at present for the many relatively folk prescriptions of Chinese medicine of diabetes, proved recipe, lack the clinical drug efficacy study of system perfecting, and Chinese prescription is according to having nothing in common with each other, rule for the treatment of disunity, therefore base oneself upon Chinese medicine, according to the pathogenesis of diabetes, treatment primary disease high effect nontoxic is explored in positive searching and effort, medicine easy to carry, have great importance.
Summary of the invention
Goal of the invention: the object of the invention is to solve the deficiencies in the prior art, there is provided a kind of proportioning scientific and reasonable, obviously can reduce the blood glucose of diabetes and complication nephrotic thereof, improve renal function, and well can reduce blood fat, improve the Chinese medicine compound of patient clinical symptom; Another object of the present invention is to provide preparation method and its application of this Traditional Chinese medicine compound composition.
Technical scheme: in order to realize above object, the technical scheme that the present invention takes is:
Have a Traditional Chinese medicine compound composition for treatment diabetes effect, it is made up of the crude drug of following parts by weight: Radix Astragali 30-90 part, Radix Rehmanniae 20-60 part, Fructus Corni 10-30 part, Cortex Moutan 10-30 part, Radix Salviae Miltiorrhizae 20-60 part, Flos abelmoschi manihot 10-30 part.
As a preferred version, the above-described Traditional Chinese medicine compound composition with the effect for the treatment of diabetes, it is made up of the crude drug of following parts by weight: Radix Astragali 30-60 part, Radix Rehmanniae 20-40 part, Fructus Corni 10-20 part, Cortex Moutan 10-20 part, Radix Salviae Miltiorrhizae 20-40 part, Flos abelmoschi manihot 10-20 part.
Preferably, the above-described Traditional Chinese medicine compound composition with the effect for the treatment of diabetes, it is made up of the crude drug of following parts by weight: Radix Astragali 30 parts, 20 parts, the Radix Rehmanniae, Fructus Corni 10 parts, Cortex Moutan 10 parts, Radix Salviae Miltiorrhizae 20 parts, Flos abelmoschi manihot 10 parts.
The present invention, according to Chinese medical theory and Pathogenesis of Diabetic Nephropathy, is screened by great many of experiments, the Chinese medicine compound that the present invention preferably obtains, and is made up of Radix Astragali, the Radix Rehmanniae, Fructus Corni, Cortex Moutan, Radix Salviae Miltiorrhizae, Flos abelmoschi manihot.Wherein, Radix Astragali sweet in the mouth, slightly warm in nature; Return lung, spleen, liver, kidney channel; Shennong's Herbal records Radix Astragali energy, and " mend husband deficient, five kinds of over strain weakness and emaciation, quenches the thirst, and stomachache lets out dysentery, QI invigorating, Li Yin gas." be harmonious with the pathogenesis of the with the passing of time deficiency of both QI and YIN of quenching one's thirst.Modern pharmacological research result shows it and is improved immunologic function, and antioxidation, protection cardiovascular and cerebrovascular vessel, kidney etc., blood fat reducing, blood sugar lowering, the albuminuretic effect of elimination diabetes are monarch drug.Radix Rehmanniae sweet in the mouth, cold in nature.GUIXIN, liver, kidney channel.Function clearing away heat and cooling blood, yin nourishing, promotes the production of body fluid.For calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst ... " Mingyi Bielu ": " Great Cold, sweet in the mouth is flat, nontoxic.Separate all heat, removing blood stasis, the tonneau moon water blockage exhausted.Not dredging water passages, smashes thin trusted subordinate, can repercussive blood.Empty and the frequent fever of patient, adds and uses it." Fructus Corni sour in the mouth, tepor, property is put down.Function invigorating the liver and kidney, arresting seminal emission gas, Gu collapse.Cure mainly: control soreness of waist and knee joint, dizzy, tinnitus, sexual impotence, seminal emission, frequent micturition etc." Mingyi Bielu ": " warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards are perspired, reinforcing YIN-essence, benefit essence, settling five organs, logical nine orifices, only normal urination, and improving eyesight is powerful ".The pharmacological research display Radix Rehmanniae and Fructus Corni all have immunity moderation, antiinflammatory, sterilization, blood sugar lowering, anti-ageing pharmacological action of waiting for a long time, and are combined into ministerial drug, the power of principal drug assistance Radix Astragali boosting qi and nourishing yin.Radix Salviae Miltiorrhizae bitter in the mouth, is slightly cold.GUIXIN, pericardium, Liver Channel.Have blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, clear away heart-fire relieving restlessness, and effect of removing heat from blood eliminating carbuncle is minister, and pharmacological research display Radix Salviae Miltiorrhizae has protection vascular endothelial cell, improves microcirculation, suppresses and removes platelet aggregation, improving the effects such as body's hypoxia tolerance.Cortex Moutan bitter in the mouth, pungent, be slightly cold.GUIXIN, liver, kidney channel.Merit is at clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.Pharmacological research shows it and mainly contains and resist myocardial ischemia, blood pressure lowering, blood sugar lowering, blood fat reducing, improve hemorheology, antioxidation, antibacterial anti-inflammatory etc.Flos abelmoschi manihot sweet in the mouth, cold in nature.Return kidney, urinary bladder channel.There is eliminating damp-heat, the effect of subduing swelling and detoxicating, be harmonious with the scorching card of the diabetic nephropathy deficiency of YIN.Pharmacological research shows it and has pharmacological actions such as improving renal function, blood sugar lowering, promotion angiogenesis.Be mainly used in clinically treating acute and chronic nephritis, diabetic nephropathy.Radix Salviae Miltiorrhizae, Cortex Moutan, Flos althaeae roseae share, and play heat clearing and blood circulation promoting altogether, and the effect of detumescence dredging collateral, the pathogenesis hindered with the stagnant heat numbness of diabetic nephropathy is comparatively in step with, and is be adjuvant drug.We's through-supplementation, righting and do not help heresy, is not eliminating evilly just hindering, and in conjunction with modern pharmacology, all medicines all have good blood sugar lowering and protect kidney effect, and safety non-toxic, and real for treatment deficiency of both QI and YIN, to accompany stagnant heat patients with type Ⅰ DM first-selected.
There is a medicine for treatment diabetic nephropathy effect, the extract of Traditional Chinese medicine compound composition and pharmaceutically acceptable carrier are prepared into the medicine of oral liquid, granule, capsule, tablet, injectable powder, drop pill, soft capsule or injection dosage form.
The Traditional Chinese medicine compound composition with the effect for the treatment of diabetes of the present invention, is prepared into the medicine of oral liquid, granule, capsule, tablet, injectable powder, drop pill, soft capsule or injection dosage form by each raw extract and pharmaceutically acceptable carrier.
When the extract of each raw material of Chinese medicine compound provided by the invention is made oral liquid, dissolved by the extract adding distil water of each raw material, filter, adjust ph, makes oral liquid.
When the extract of each raw material of Chinese medicine compound provided by the invention is made tablet, each raw material and lactose or corn starch, add magnesium stearate lubricant when needing, mix homogeneously, granulate, then tablet made by tabletting.
The extract of each raw material and carrier lactose or corn starch mix homogeneously when the extract of Chinese medicine compound provided by the invention makes capsule, granulate, then encapsulatedly makes capsule.
When the extract of each raw material of Chinese medicine compound provided by the invention makes granule, the extract of each raw material and diluent lactose or corn starch, mix homogeneously, granulate, dry, make granule.
When the extract of each raw material of Chinese medicine compound provided by the invention makes injectable powder, the extract lyophilization of each raw material, sterilization, makes injectable powder.
When the extract of each raw material of Chinese medicine compound provided by the invention makes injection, the extract getting each raw material adds physiological saline solution and then adds active carbon, stir, 80 DEG C are heated 30 minutes, filter, adjust ph, with sintered glass funnel or other frit to clear and bright, fill, makes injection in 30 minutes 100 to 115 DEG C of sterilizings.
The preparation method with the medicine for the treatment of diabetic nephropathy effect of the present invention, comprises the following steps:
(1) get Radix Astragali, the Radix Rehmanniae, Fructus Corni by weight, add the soak by water of medical material weight 8 ~ 10 times amount or reflux, extract, 2 ~ 3 times, each 1 ~ 2 hour, merge extractive liquid, concentratedly to obtain extractum, for subsequent use;
(2) get Cortex Moutan by weight, Radix Salviae Miltiorrhizae, Flos abelmoschi manihot adopt alcohol extracting method, with the alcohol reflux 2 ~ 3 times of medical material weight 8 ~ 10 times amount, each 1 ~ 2 hour, merge extractive liquid, reclaimed ethanol, concentratedly to obtain extractum, for subsequent use;
(3) medicine that extractum that step (1) obtains and the extractum that step (2) obtains and pharmaceutically acceptable carrier are prepared into oral liquid, granule, capsule, tablet, injectable powder, drop pill, soft capsule or injection dosage form is got.
The application of Traditional Chinese medicine compound composition in preparation treatment diabetes medicament with the effect for the treatment of diabetes of the present invention.
The application of Traditional Chinese medicine compound composition in preparation treatment medicine for treating diabetic nephropathy with the effect for the treatment of diabetes of the present invention.
The application of Traditional Chinese medicine compound composition in preparation control hyperlipidemia with diabetes medicine with the effect for the treatment of diabetes of the present invention.
The Traditional Chinese medicine compound composition with the effect for the treatment of diabetes of the present invention prevents and treats the application in diabetes merging peripheral neuritis medicine in preparation.
Beneficial effect: the present invention is according to the Chinese medical theory of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, pathogeny according to diabetes and complication thereof carries out Chinese prescription screening, the Chinese medicine compound proportioning provided is scientific and reasonable, medication is rigorous, experimental result shows, Traditional Chinese medicine compound composition provided by the invention has good effect of lowering blood sugar, and have and well reduce microdose urine protein, Urine β2-microglobulin, blood Cr and blood BUN effect, there is good Renoprotective Effect, and experimental result shows, Chinese medicine compound provided by the invention also has and well has anti-inflammatory efficacy, to diabetes peripheral neuritis, there is good prophylactic-therapeutic effect.And Chinese medicine composition provided by the invention significantly can also reduce TC, TG, LDL-C of diabetics, there is the effect significantly reducing blood fat.And Traditional Chinese medicine compound composition life-time service toxic and side effects provided by the invention is little, and drug safety is reliable.
Detailed description of the invention
The present invention is illustrated further below in conjunction with specific embodiment, these embodiments should be understood only be not used in for illustration of the present invention and limit the scope of the invention, after having read the present invention, the amendment of those skilled in the art to the various equivalent form of value of the present invention has all fallen within the application's claims limited range.
Embodiment 1
1, have a Traditional Chinese medicine compound composition for treatment diabetes effect, it is made up of the crude drug of following parts by weight: Radix Astragali 30g, Radix Rehmanniae 20g, Fructus Corni 10g, Cortex Moutan 10g, Radix Salviae Miltiorrhizae 20g, Flos abelmoschi manihot 10g.
2, the preparation method with the Traditional Chinese medicine compound composition for the treatment of diabetes effect of the present invention, it comprises the following steps:
(1) get Radix Astragali 30g, Radix Rehmanniae 20g, Fructus Corni 10g by weight, add the water boiling and extraction 3 times of medical material weight 10 times amount, each 1 hour, merge extractive liquid, concentratedly to obtain extractum, for subsequent use;
(2) get Cortex Moutan 10g, Radix Salviae Miltiorrhizae 20g, Flos abelmoschi manihot 10g by weight, with the alcohol reflux 2 times of medical material weight 8 times amount, each 2 hours, merge extractive liquid, reclaimed ethanol, concentratedly to obtain extractum, for subsequent use;
(3) get extractum that step (1) obtains and the extractum that step (2) obtains is mixed homogeneously with carrier lactose or corn starch, granulate, then encapsulatedly make capsule.(lot number: 001)
Embodiment 2
1, have a Traditional Chinese medicine compound composition for treatment diabetes effect, it is made up of the crude drug of following parts by weight: Radix Astragali 90g, Radix Rehmanniae 60g, Fructus Corni 30g, Cortex Moutan 30g, Radix Salviae Miltiorrhizae 60g, Flos abelmoschi manihot 30g.
2, the preparation method with the Traditional Chinese medicine compound composition for the treatment of diabetes effect of the present invention, it comprises the following steps:
(1) get Radix Astragali 90g, Radix Rehmanniae 60g, Fructus Corni 30g by weight, add the water reflux, extract, 2 times of medical material weight 8 times amount, each 2 hours, merge extractive liquid, concentratedly to obtain extractum, for subsequent use;
(2) get Cortex Moutan 30g, Radix Salviae Miltiorrhizae 60g, Flos abelmoschi manihot 30g by weight, with the alcohol reflux 3 times of medical material weight 10 times amount, each 1 hour, merge extractive liquid, reclaimed ethanol, concentratedly to obtain extractum, for subsequent use;
(3) get extractum that step (1) obtains and the extractum that step (2) obtains, adding distil water dissolves, and filter, adjust ph, makes oral liquid.(lot number: 002)
Embodiment 3
1, have a Traditional Chinese medicine compound composition for treatment diabetes effect, it is made up of the crude drug of following parts by weight: Radix Astragali 60g, Radix Rehmanniae 40g, Fructus Corni 20g, Cortex Moutan 20g, Radix Salviae Miltiorrhizae 40g, Flos abelmoschi manihot 20g.
2, the preparation method with the Traditional Chinese medicine compound composition for the treatment of diabetes effect of the present invention, it comprises the following steps:
(1) get Radix Astragali 60g, Radix Rehmanniae 40g, Fructus Corni 20g by weight, add the water reflux, extract, 2 times of medical material weight 12 times amount, each 1 hour, merge extractive liquid, concentratedly to obtain extractum, for subsequent use;
(2) get Cortex Moutan 20g, Radix Salviae Miltiorrhizae 40g, Flos abelmoschi manihot 20g by weight, with the alcohol reflux 2 times of medical material weight 8 times amount, each 2 hours, merge extractive liquid, reclaimed ethanol, concentratedly to obtain extractum, for subsequent use;
(3) get extractum that step (1) obtains and the extractum that step (2) obtains, add diluent cyclodextrin or corn starch mix homogeneously, granulate, dry, make granule.(lot number: 003)
Embodiment 4
The extractum that Example 1 step (1) obtains and the dry extract lyophilization that step (2) obtains, sterilization, makes injectable powder.(lot number: 004)
Embodiment 5 clinical research
One. case selection, grouping and treatment
All cases are Nanjing Traditional Chinese Medicine Univ. affiliated hospital, Nanjing University of Traditional Chinese Medicine Chinese and Western in conjunction with the patient of out-patient department.Be the patient making a definite diagnosis diabetes and nephropathy thereof.The standard that doctor trained in Western medicine name diagnosis is worked out with reference to " practical internal medicine " the 11st edition.Chinese medical discrimination is " deficiency of both QI and YIN, stagnant heat resistance network " card.
Include case standard in: (1) 45-70 year; (2) diabetes or diabetic nephropathy is had; (3) doctor trained in Western medicine name diagnosis standard and Standards of Chinese Medical Syndrome Differentiation is met, through blood glucose and the kidney function test person of meeting.
Experiment grouping: 80 examples are divided into Traditional Chinese medicine compound composition group 40 of the present invention example at random, matched group (Liuwei Dihuang granule group) 40 example.Primary condition through statistical procedures, two groups of there was no significant differences (P>0.05).Dosage: treatment group takes the Traditional Chinese medicine compound composition that the embodiment of the present invention 1 prepares, every day 2 times; Matched group Liuwei Dihuang granule, every day 2 times.Treatment cycle is 30 days.
(1) two group of blood glucose compares
Table one: medicine is on the impact of blood glucose
* P < 0.01, compares with before corresponding treatment of control group; #P < 0.01, compares before treating with corresponding Traditional Chinese medicine compound composition group; AP < 0.01, compares with after corresponding treatment of control group
Shown by the experimental result of table one, treat front two groups of fasting glucose, after the meal 2 hours blood glucoses, glycolated hemoglobin there was no significant difference (P > 0.05); Treat rear two groups of fasting glucose, obvious decline all appears in 2 hours blood glucoses, glycolated hemoglobin after the meal; Fasting glucose, after the meal 2 hours blood glucoses, glycolated hemoglobin wherein after Traditional Chinese medicine compound composition treatment provided by the invention obviously reduce.Result shows that Chinese medicine composition provided by the invention has good hypoglycemic activity.
(2) two groups of renal functioies compare
Table two: medicine is on the impact of renal function
* P < 0.01, compares with before corresponding treatment of control group; #P < 0.01, compares before treating with corresponding Traditional Chinese medicine compound composition group; AP < 0.01, compares with after corresponding treatment of control group
Treat front two groups of microdose urine proteins, Urine β2-microglobulin, blood Cr, blood BUN there was no significant difference (P > 0.05); After treatment there is obvious decline in two groups of microdose urine proteins, Urine β2-microglobulin, blood Cr, blood BUN; Microdose urine protein wherein after the treatment of Traditional Chinese medicine compound composition group, Urine β2-microglobulin, blood Cr, blood BUN are starkly lower than the value after treatment of control group.Result shows Traditional Chinese medicine compound composition provided by the invention and has protecting renal function effect, has well treatment diabetic nephropathy effect.
(3) two groups of inflammatory factors compare
Table three: medicine is on the impact of inflammatory factor
* P < 0.01, compares with before corresponding treatment of control group; #P < 0.01, compares before treating with corresponding Traditional Chinese medicine compound composition group; AP < 0.01, compares with after corresponding treatment of control group
Treat front two groups of TNFa, IL-6 there was no significant differences (P > 0.05); After treatment there is obvious decline in two groups of TNFa, IL-6; TNFa, IL-6 wherein after the treatment of Traditional Chinese medicine compound composition group are lower than the value after treatment of control group.Result shows Traditional Chinese medicine compound composition provided by the invention and has good anti-inflammatory cytokine effect, has good prophylactic-therapeutic effect to diabetes peripheral neuritis.
(4) two groups of four items of blood lipid tests compare
Table four: medicine is on the impact of blood fat
* P < 0.01, compares with before corresponding treatment of control group; #P < 0.01, compares before treating with corresponding Traditional Chinese medicine compound composition group; AP < 0.01, compares with after corresponding treatment of control group
Treat front two groups of TC, TG, LDL-C, HDL-C there was no significant differences (P > 0.05); After treatment, obviously declining appears in matched group TC, LDL-C; After treatment, obviously declining appears in Traditional Chinese medicine compound composition group TC, TG, LDL-C; TC, TG, LDL-C wherein after the treatment of Traditional Chinese medicine compound composition group are lower than the value after treatment of control group.Result display Traditional Chinese medicine compound composition has and well reduces blood fat.
The present invention is according to Chinese medical theory, the theory of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs is adopted to carry out proportioning prescription, shown by above experimental result, Chinese medicine compound provided by the invention has the comprehensive function of too many levels, Mutiple Targets, the carbohydrate metabolism disturbance of diabetics can be corrected, have and reduce blood glucose and blood fat, improve insulin resistant, can be used for control hyperlipidemia with diabetes and diabetes close nephropathy and terminal nerve inflammatory diseases thereof, and clinical trial results shows that Chinese medicine compound life-time service provided by the invention has no adverse reaction, medication is safer.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (9)
1. one kind has the Traditional Chinese medicine compound composition for the treatment of diabetes effect, it is characterized in that, it is made up of the crude drug of following parts by weight: Radix Astragali 30-90 part, Radix Rehmanniae 20-60 part, Fructus Corni 10-30 part, Cortex Moutan 10-30 part, Radix Salviae Miltiorrhizae 20-60 part, Flos abelmoschi manihot 10-30 part.
2. the Traditional Chinese medicine compound composition with the effect for the treatment of diabetes according to claim 1, it is characterized in that, it is made up of the crude drug of following parts by weight: Radix Astragali 30-60 part, Radix Rehmanniae 20-40 part, Fructus Corni 10-20 part, Cortex Moutan 10-20 part, Radix Salviae Miltiorrhizae 20-40 part, Flos abelmoschi manihot 10-20 part.
3. the Traditional Chinese medicine compound composition with the effect for the treatment of diabetes according to claim 2, it is characterized in that, it is made up of the crude drug of following parts by weight: Radix Astragali 30 parts, 20 parts, the Radix Rehmanniae, Fructus Corni 10 parts, Cortex Moutan 10 parts, Radix Salviae Miltiorrhizae 20 parts, Flos abelmoschi manihot 10 parts.
4. one kind has the medicine for the treatment of diabetes effect, it is characterized in that, the extract of the Traditional Chinese medicine compound composition described in any one of claims 1 to 3 and pharmaceutically acceptable carrier are prepared into the medicine of oral liquid, granule, capsule, tablet, injectable powder, drop pill, soft capsule or injection dosage form.
5. the preparation method with the medicine for the treatment of diabetes effect according to claim 4, is characterized in that, comprise the following steps:
(1) get Radix Astragali, the Radix Rehmanniae, Fructus Corni by the parts by weight described in any one of claims 1 to 3, add the soak by water of medical material weight 8 ~ 10 times amount or reflux, extract, 2 ~ 3 times, each 1 ~ 2 hour, merge extractive liquid, concentratedly to obtain extractum, for subsequent use;
(2) get Cortex Moutan, Radix Salviae Miltiorrhizae, Flos abelmoschi manihot by the parts by weight described in any one of claims 1 to 3, with the alcohol reflux 2 ~ 3 times of medical material weight 8 ~ 10 times amount, each 1 ~ 2 hour, merge extractive liquid, reclaimed ethanol, concentratedly to obtain extractum, for subsequent use;
(3) medicine that extractum that step (1) obtains and the extractum that step (2) obtains and pharmaceutically acceptable carrier are prepared into oral liquid, granule, capsule, tablet, injectable powder, drop pill, soft capsule or injection dosage form is got.
6. the application of the Traditional Chinese medicine compound composition with the effect for the treatment of diabetes in preparation treatment diabetes medicament described in any one of claims 1 to 3.
7. the application of the Traditional Chinese medicine compound composition with the effect for the treatment of diabetes in preparation treatment medicine for treating diabetic nephropathy described in any one of claims 1 to 3.
8. the application of the Traditional Chinese medicine compound composition with the effect for the treatment of diabetes described in any one of claims 1 to 3 in preparation control hyperlipidemia with diabetes medicine.
9. the Traditional Chinese medicine compound composition with the effect for the treatment of diabetes described in any one of claims 1 to 3 prevents and treats the application in diabetes merging peripheral neuritis medicine in preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510405578.XA CN104906251B (en) | 2015-07-10 | 2015-07-10 | A kind of Traditional Chinese medicine compound composition with treatment diabetes effect and preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510405578.XA CN104906251B (en) | 2015-07-10 | 2015-07-10 | A kind of Traditional Chinese medicine compound composition with treatment diabetes effect and preparation method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104906251A true CN104906251A (en) | 2015-09-16 |
| CN104906251B CN104906251B (en) | 2017-12-08 |
Family
ID=54075968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510405578.XA Active CN104906251B (en) | 2015-07-10 | 2015-07-10 | A kind of Traditional Chinese medicine compound composition with treatment diabetes effect and preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104906251B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108066650A (en) * | 2018-01-26 | 2018-05-25 | 江苏省中医院 | A kind of Traditional Chinese medicine compound composition with treatment metabolic syndrome effect and preparation method and application |
| CN108159300A (en) * | 2018-01-26 | 2018-06-15 | 严士海 | A kind of Traditional Chinese medicine compound composition with treatment hypertension complicated with diabetes mellitus effect and preparation method and application |
| CN113908235A (en) * | 2021-12-02 | 2022-01-11 | 江苏省中医院 | Traditional Chinese medicine compound preparation for treating diabetic retinopathy and preparation method and application thereof |
| CN116808156A (en) * | 2023-05-15 | 2023-09-29 | 江苏省中医院 | Traditional Chinese medicine composition for preventing and treating atherosclerosis and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485825A (en) * | 2008-01-16 | 2009-07-22 | 北京天科仁祥医药科技有限公司 | Chinese medicine capsule for treating diabetes |
| CN102861201A (en) * | 2011-07-05 | 2013-01-09 | 北京中医药大学 | Medicine composition for treating diabetes and preparation method thereof |
| CN104645132A (en) * | 2013-11-25 | 2015-05-27 | 张宁 | Traditional Chinese medicine composition for treating diabetic nephropathy, preparation method, traditional Chinese medicine preparation and application of traditional Chinese medicine composition |
-
2015
- 2015-07-10 CN CN201510405578.XA patent/CN104906251B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485825A (en) * | 2008-01-16 | 2009-07-22 | 北京天科仁祥医药科技有限公司 | Chinese medicine capsule for treating diabetes |
| CN102861201A (en) * | 2011-07-05 | 2013-01-09 | 北京中医药大学 | Medicine composition for treating diabetes and preparation method thereof |
| CN104645132A (en) * | 2013-11-25 | 2015-05-27 | 张宁 | Traditional Chinese medicine composition for treating diabetic nephropathy, preparation method, traditional Chinese medicine preparation and application of traditional Chinese medicine composition |
Non-Patent Citations (2)
| Title |
|---|
| 方朝晖等: "历代消渴名方治疗糖尿病概述", 《中医药临床杂志》 * |
| 程万里主编: "《中医内科诀窍》", 29 February 2012 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108066650A (en) * | 2018-01-26 | 2018-05-25 | 江苏省中医院 | A kind of Traditional Chinese medicine compound composition with treatment metabolic syndrome effect and preparation method and application |
| CN108159300A (en) * | 2018-01-26 | 2018-06-15 | 严士海 | A kind of Traditional Chinese medicine compound composition with treatment hypertension complicated with diabetes mellitus effect and preparation method and application |
| CN108066650B (en) * | 2018-01-26 | 2020-08-04 | 江苏省中医院 | Traditional Chinese medicine compound composition with effect of treating metabolic syndrome and preparation method and application thereof |
| CN113908235A (en) * | 2021-12-02 | 2022-01-11 | 江苏省中医院 | Traditional Chinese medicine compound preparation for treating diabetic retinopathy and preparation method and application thereof |
| CN116808156A (en) * | 2023-05-15 | 2023-09-29 | 江苏省中医院 | Traditional Chinese medicine composition for preventing and treating atherosclerosis and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104906251B (en) | 2017-12-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101947284B (en) | Traditional Chinese medicinal composition for treating diabetes and preparation method thereof | |
| CN103301412A (en) | Traditional Chinese medicine composition for treating alcoholic liver | |
| CN104906251A (en) | Traditional Chinese medicine compound combination with diabetes treating effect and preparation method and application thereof | |
| CN101642542B (en) | Capsule for nourishing liver and kidney and reducing blood pressure | |
| CN101007157A (en) | Traditional Chinese medicine compound preparation for treating chronic cholecystitis | |
| CN103223069A (en) | Traditional Chinese medicine composition for treating hepatitis | |
| CN102631526A (en) | Chinese medicinal composition for treating diabetes mellitus | |
| CN101607031B (en) | Medicated wine for curing and preventing diabetes mellitus, preparation method and application method thereof | |
| CN101530489B (en) | Chinese medicine composition used for treating non-active stage infiltrative exophthalmos of thyroid-associated ophthalmopathy and preparation method thereof | |
| CN104857436A (en) | Chinese herbal compound composition with anti-hepatoma activity as well as preparation method and application of Chinese herbal compound composition | |
| CN101732585A (en) | Medicinal composition for treating migraine, preparation method and application thereof | |
| CN115252753A (en) | Traditional Chinese medicine composition for treating insomnia and application thereof | |
| CN101380405B (en) | Traditional Chinese medicine preparation for treating cholelithiasis and preparation method thereof | |
| CN100453099C (en) | Lefukang preparation and its preparing process | |
| CN103520684B (en) | Traditional Chinese medicine compound for reducing blood sugar | |
| CN103393938B (en) | Traditional Chinese medicine composition for reducing blood sugar | |
| CN102228596B (en) | Pharmaceutical composition and preparation and applications thereof in treating coronary heart disease and angina pectoris | |
| CN1907345A (en) | Chinese traditional medicine composition for treating cerebral apoplexy | |
| CN1857531A (en) | Recipe, preparing process and application of Chinese medicine preparation for treating diabetic retinopathy | |
| CN104056207B (en) | Traditional Chinese medicine combination for treating stomach cancer and preparation method for same | |
| CN103585495A (en) | Capsule for treating diabetic kidney damage | |
| CN112206279B (en) | Traditional Chinese medicine composition for treating ventricular arrhythmia and preparation method and application thereof | |
| CN108186758A (en) | A kind of Chinese medicine composition of qi and activate blood circulation and preparation method thereof | |
| CN100525822C (en) | Capsule for treating diabetic nephropathy | |
| CN108578560B (en) | Traditional Chinese medicine composition for treating liver-kidney yin deficiency type autoimmune hepatitis and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |