CN104897912A - Biological sample analyzing device - Google Patents
Biological sample analyzing device Download PDFInfo
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- CN104897912A CN104897912A CN201510243006.6A CN201510243006A CN104897912A CN 104897912 A CN104897912 A CN 104897912A CN 201510243006 A CN201510243006 A CN 201510243006A CN 104897912 A CN104897912 A CN 104897912A
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- Investigating Or Analysing Biological Materials (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention provides a biological sample analyzing device. The biological sample analyzing device comprises a main control unit and at least two mutually independent testing units; the main control unit is interconnected with a main power control switch, a data output/input control system, and the testing units respectively; and each of the testing unit at least comprises a sample delivering device and a light source device. The biological sample analyzing device can be used for detecting of a series of physiological and biochemical indexes including glucose, cholesterol, high density fatty acid, low density fatty acids, triglycerides, uric acid, bilirubin, total protein, hemoglobin, and ketone body.
Description
Technical field
The present invention relates to the biochemical analysis tester for measuring clinical physiological Indexs measure and method of testing, especially the biochemical analysis tester of Fast Measurement biochemical indicator and method of testing.
Background technology
Along with the progress of science and technology, bedside in-vitro diagnosis experiment (POCT:Point of Care Testing) in laboratory medicine field is arisen at the historic moment and is rapidly developed.The dry chemical method of " soak and read " (dip-and-read) of the fifties appearance of 20 century refers to and is directly added on dry type reagent strip by fluid test sample, cause specific chemical reaction on reagent strip using the moisture of sample as solvent, thus carry out the method for sample analysis.The features such as biochemical dry type test paper method finding speed easy to carry with it, simple to operate is fast, also play a significant role in detecting fast at the scene.Along with the introduction of immune response and molecular biotechnology, the inspection field of medical science dry type test paper method expands to the detection of blood sugar, gestation, blood coagulable status, myocardial damage, acid base equilibrium, infectious diseases etc., and therapeutic drug monitori (TMD), alcohol content detection, thrombotest, the analysis of Blood Biochemical Indexes, infectious disease are sieved, operation time hormonal readiness and microchip DNA diagnoses and drug abuse detection etc.Ocular estimate is relied on to judge the testing result of dry chemical test paper, can only as qualitative judgement or semiquantitative judgement.Therefore for making the interpretation of quick detection test paper more accurate, miniaturization detecting instrument supporting with it progressively grows up.These detecting instruments are easy and simple to handle, go out result fast, accurately.And the data that these detecting instruments obtain can also realize remote wireless transmission to laboratory computer management system or formation electronic health record.
US Patent No. 4780283 discloses a kind of dry chemical test paper analyser.This analyser comprises fixed detection light source, loads the hemispherical workbench of test paper bar.By the interaction between spring, hemispherical workbench is transported to detection light source place to detect.Owing to just make use of the mechanicals efforts between spring, not only in production, require very accurately control procedure, increase production cost, and utilize the interaction of spring to be difficult to control the tram between reaction reagent bar and detection light source, affect testing result.And hemispherical structure, add the volume of whole analytical instrument.On the other hand, spring is short for serviceable life, needs regular replacing spring, and this can make troubles to the user of instrument.
Praxsys Biosystems Inc. company of the U.S. develops a kind of tachysynthesis detection system that can be used for quantitative and qualitative analysis and judge, disclose in US Patent No. 6136610, this system is made up of detector and Test paper box supporting with it.This system uses single channel, namely once only can detect single clinical samples.Because this detecting instrument once can only detect an index, therefore detection efficiency is lower.
Chinese patent application 200910160639.5 discloses a kind of multi-channel portable colloidal gold test paper device for quick testing, mainly comprises: 4 independently sense channel, ARM data processor, keyboard and LCD parts.The pick-up unit of this invention can be quick and high-throughoutly complete multiple test item.But 4 of this Chinese patent application independently sense channel and whole detector be an entirety, instrument user not by change sense channel arbitrarily change test event.
Chinese patent application 200410052202.7 discloses a kind of quick diagnosis lateral flow assays system and method, this detection system comprises 1 master unit and 1 to 20 test module, and being connected to host computer by USB or blue teeth wireless receiver, host computer is run by software control detector.This patented claim also discloses between master unit and test module and is designed to relatively independent relation, and when master unit breaks down, all proving installations can be removed and ressemble with another master unit.It is a very complicated process that test module described in this patented claim disassembles from master unit, needs a lot of parts of breakdown.On the other hand, described test module is not a closed structure, when the sample retained in the test module be removed when having test or test agent, these residual samples or reagent can be exposed in the environment, not only pollute the environment of surrounding, also can form the life security of operating personnel dangerous.
In existing detector, be all often single pass, namely once can only detect the sample of single patient.This single pass detector, at the limited sample of unit interval build-in test, when processing the extensive health check-up of large contingent, often causes a large amount of delays of medical examiner.
In the application of sample process of carrying out sample detection, test paper is first placed on experiment desktop, then drips sample.Because test paper all can be thinner thus can tightly be bonded on laboratory table, when dripping sample, when needing again to pick up test paper, will be more difficult, the more time need be spent, delay correct detection time.
On the other hand, if operator's error, when not fastening test gate with regard to open detection program, such external interference light will enter test position, causes testing result inaccurate, particularly utilizes the detector of optical detection principle.
Summary of the invention
An object of the present invention is to provide one
Owing to adopting technique scheme, present invention offers following beneficial effect: coordinated by mobile in master control set guide rail of the slide block on proving installation in proving installation, proving installation can be realized and be installed on master control set or by proving installation and disassemble from master control set.This operating process is simple, convenient.
Owing to can also receive reagent storage unit in storage chamber, operator can be placed in the reagent rack of reagent storage unit the reagent needed in advance, just can take out the reagent of needs during detection easily from described reagent storage frame.If the proving installation of certain type is by Long-Time Service, then its corresponding reagent storage unit also can long-term storage in master control set, form man-to-man relation with proving installation, prevent from misusing reagent.Reagent storage unit is incorporated in master control set, makes operating table surface be unlikely to pile with reagent bottle, prevents the hazard events such as reagent bottle tipping.
The principle that magnetic block lock catch structure of the present invention make use of the two like magnetic poles attract each other of magnetic patch, the opposite sex is repelled each other, effectively achieves the assembling between proving installation and master control set.Magnetic block lock catch structure of the present invention, does not need operator to use a lot of strength, and also do not need operator to dismantle such as a lot of screw nuts etc., whole process is very simple and convenient.
Of the present inventionly the rack-plate on driving stepper motor gear driven microscope carrier is utilized to run, thus drive the motion of test paper carrier bench, not only increase test speed, and the driving effect of stepper motor continuous and stable, can stablize and accurately microscope carrier is transported to tram.
The bottom of microscope carrier be designed with track base on guide rail and base with the use of, make microscope carrier can level and smooth moving in proving installation, decrease the interference of noise.
Baffle plate of the present invention not only plays good protection to the test strips microscope carrier in proving installation and light source transmitter-receiver device, makes microscope carrier and light source transmitter-receiver device from external force collision, prevents dust pollution.Simultaneously when proving installation is deposited separately, because proving installation is a closed structure, when the sample retained in the proving installation be removed when having test or test agent, reagent residual on microscope carrier or sample can not be exposed in external environment, prevent the pollution to surrounding environment and operator.
Biochemical Analyzer of the present invention also comprises the supporting structure for support operation panel, because guidance panel is when establishing, has thereafter support to support, and operator is when using panel button, and guidance panel can not cave in backward.
Beneficial effect of the present invention also comprises: 1) Biochemical Analyzer of the present invention adopts the pattern of multiple separate test cell, adds the sample size of unit interval build-in test, improves detection efficiency.2) method of testing of the present invention includes multiple determining step, improves the accuracy of detection, reduces the inaccurate risk of test result that manual operation mistake causes.3) magnetic induction start device is included at test cell of the present invention, can not only effectively ensure when starting test like this, test cell door is closed, also do not need additionally to add other unit lock locking devices simultaneously, just test cell door can be closed closely, get rid of the interference of external light source.4) Biochemical Analyzer of the present invention, owing to having installed test paper application of sample operator's console on instrument, the bottom surface of test paper being affectedly bashful position has not touched experiment desktop, makes operator more easily be affectedly bashful the test paper having added sample.
Accompanying drawing explanation
Fig. 1 Biochemical Analyzer schematic diagram; Fig. 2 Biochemical Analyzer guidance panel open mode schematic diagram; The view that a proving installation in Fig. 3 Biochemical Analyzer is drawn out of; Reagent storage cell schematics is had in Fig. 4 Biochemical Analyzer; The rear structure schematic diagram of Fig. 5 Biochemical Analyzer and proving installation; The second design diagram that the guidance panel of Fig. 6 Biochemical Analyzer is supported by support; The proving installation inner structure schematic diagram of Fig. 7 Biochemical Analyzer; The cut-open view in the proving installation A-A direction along the line of Fig. 8 Biochemical Analyzer; The proving installation door of the proving installation of Fig. 9 Biochemical Analyzer opens schematic diagram; The schematic diagram that in the first magnetic block lock catch structure of Figure 10, the first magnetic patch and the second magnetic patch attract each other; First magnetic patch and the separated schematic diagram of the second magnetic patch in the first magnetic block lock catch structure of Figure 11; Figure 12 the second magnetic block lock catch structure schematic diagram; The third magnetic block lock catch structure schematic diagram of Figure 13; Figure 14 Biochemical Analyzer test flow chart; Figure 15 is the schematic diagram of another embodiment of biochemical analysis tester of the present invention; Figure 16 is the test cell door open mode schematic diagram of the biochemical analysis tester shown in Figure 15; Figure 17 is the biochemical analysis tester sectional view shown in Figure 15; Figure 18 is test cell sectional view in the biochemical analysis tester shown in Figure 15; Figure 19 is magnetic induction switch on the test cell door shown in Figure 16 and magnetic patch positional structure schematic diagram; Figure 20 is the hardware composition diagram of the Biochemical Analyzer shown in Figure 15; Figure 21 is the method for testing process flow diagram of the Biochemical Analyzer shown in Figure 15.
Embodiment
Below in conjunction with concrete accompanying drawing, the present invention will be described in detail.These specific embodiments are only without prejudice to the limited list under spirit of the present invention, do not get rid of other specific embodiments that one of ordinary skill in the art combines prior art and the present invention and produce.
As shown in Figure 1, Biochemical Analyzer 1 of the present invention comprises the separate proving installation 100 of more than a master control set 10 and or, and master control set 10 is connected by electric connector 140 and wire with proving installation 100.The instruction that each proving installation 100 can transmit according to master control set 10, completes test item and testing result is transferred to master control set 10 exporting independently of one another.Be designed to relatively independent relation between each proving installation 100, proving installation 100 freely can carry out dismounting repeatedly with master control set 10.
As shown in Figures 1 to 6, include in the casing of master control set 10 after primary power 11(connects external goods electricity consumption and power to each several part of Biochemical Analyzer).Master control set 10 also includes the master switch 12 of analyser, guidance panel 13 and printer 14.Master switch 12, guidance panel 13 and printer 14 are electrically connected with primary power 11 respectively.Guidance panel 13 is touch display screens, both can show interface and the testing result of testing process, and the person's touch screen that is not convenient to operation again operates.
The storage chamber 15 that more than one or one size is substantially suitable with proving installation 100 is provided with side by side in the casing of master control set 10.Can quick smoothly be pushed in the storage chamber 15 of master control set to make proving installation, the at least two side of storage chamber 15 is designed with guide rail 16 respectively, or there is guide rail 17 in the bottom design of storage chamber 15, or be all designed with guide rail in the two side of storage chamber and bottom.Described guide rail coordinates with the slide block on proving installation or pulley (not shown).When proving installation is assembled into master control set or from the process that master control set disassembles, the slide block on proving installation or pulley slide in guide rail, proving installation is guided to enter the storage chamber of master control set or leave storage chamber 15.
As shown in Figure 4, also the reagent storage unit 18 that size and shape is substantially suitable with proving installation 100 can be put in described storage chamber 15, in described reagent storage unit 18, one or more reagent storage frame 19 can be set, for depositing the testing element of test, this testing element can be test agent or reagent barrel etc.The advantage of this design is, can according to actual needs, and the storage chamber 15 in master control set 10 is installation testing device 100 all, or part installation testing device 100, other installation reagent storage unit 18, thus makes design more flexible.Biochemical Analyzer 1 as shown in Figure 4, includes a master control set 10, two proving installations 100 and a reagent storage unit 18.As more changeable embodiment more, Biochemical Analyzer 1 can comprise a master control set 10, to ten, the even proving installation 100 of more than ten and one to ten, the even reagent storage unit 18 of more than ten, and the quantity of proving installation 100 and storage unit 18 can arbitrarily combine according to need.Operator can be placed on the reagent needed when detecting in reagent storage frame 19 in advance.When detecting, operator can take out corresponding reaction reagent easily from the reagent storage unit of analyser.If proving installation is by Long-Time Service, then its corresponding reagent storage unit also can long-term storage in master control set, form man-to-man relation with proving installation, prevent from misusing reagent.Reagent is all sorted out and is placed in reagent storage unit in addition, makes operating table surface be unlikely to pile with reagent bottle, prevents the hazard events such as reagent bottle tipping.
The shell of master control set 10 is equipped with USB interface 26, fan 20, general supply access port 21 etc.In order to make the proving installation 100 be pushed into stably remain in storage chamber 15, on the bonnet of master control set, the position of corresponding each proving installation can also comprise bonnet lock hole 22.
Guidance panel 13 can be LCD, LED touch panel plate or some there is LCD, the LED panel of button.Guidance panel 13 is connected with master control set 10 by hinge 23, is also connected with master control set 10 with support 24 by hinge (not shown).
As shown in Figure 7 to 9, proving installation 100 comprises a base 101, and the microscope carrier 102 transporting test strip designs on base, and light source transmitter-receiver device 103 is positioned at the top of microscope carrier 102.Base 101 is fixedly designed with left socle 104 and right support 105, and microscope carrier 102 surrounds within it by left and right support.Light source transmitter-receiver device 103 is arranged on the support of left and right, or is fixedly designed with upper bracket 106 on the support of left and right, and light source transmitter-receiver device 103 is installed on upper bracket 106.Microscope carrier 102 can move back and forth at the track preset; light source transmitter-receiver device 103 can near and away from microscope carrier 102, the motion track of microscope carrier 102 and light source transmitter-receiver device 103 or the extended line of motion track mutually intersect in same plane or orthogonal projection in same plane intersects mutually.
At least one support 104 or 105 is designed with stepper motor 107, stepper motor is equipped with gear 108.The microscope carrier 102 of transport test strip comprises the pallet 110 for carrying test strip 109.Rack-plate 111 is designed with regularly at least side of microscope carrier 102.Described gear 108 engages with the rack-plate 111 on microscope carrier 102.When stepper motor works, order about driven wheel and rotate, and then order about rack-plate 111 and make linear running, thus the microscope carrier be connected with rack-plate is delivered to test zone or exits from test zone.The precision comparison of stepper motor to motion is high, therefore when the motion of gear driven rack-plate, not only increases the speed of transporting test paper, and also improves stability and the accuracy of test.
The medium position of base 101 is fixedly designed with track base 112, this track base 112 and the guide rail 113 on test strips microscope carrier 102 with the use of, microscope carrier 102 can slide along track base in proving installation, thus transports test-strips arrival detection position or exit test zone.Described guide rail 113 designs the bottom in microscope carrier 102.
There is a temperature control equipment 114 below that microscope carrier is positioned at the test zone of test strips.When the environment temperature of testing does not meet the temperature range preset, temperature control equipment will regulate temperature (such as heating) automatically, make the temperature of test environment meet the temperature range preset.Temperature control equipment comprises resistive heating device, and transmits temperature by potsherd or sheet metal.
The left and right sides of proving installation base 101 respectively can also be mounted with a take-up housing 120, and take-up housing 120 is bolted on base 101.The fixing design of slide block 121 is on take-up housing 120, this slide block 121 can be free to slide in the guide rail 16 of storage chamber 15 sidewall, thus driving whole proving installation mobile in storage chamber 15, proving installation is pushed into the detection that storage chamber prepares to carry out analyte, or is moved out of storage chamber.Take-up housing with slide block can also be arranged on the bottom of base, with the bottom guide track 17 in storage chamber with the use of.As design for change, take-up housing 120 and slide block 121 also can be an entirety, can also be bars matched with guide rail 16.
In order to better relay testing microscope carrier and light source transmitter-receiver device, can also respectively be designed with baffle plate 122-126 all around, i.e. right baffle plate 122, right baffle-plate 123, overhead gage 124, front apron 125 and backboard 126 at proving installation 100.Front apron 125 is designed with a proving installation door 127, and proving installation door 127 and front apron 125 can be connected through the hinge.When proving installation does not use or detects, proving installation door is closed.When the test strips microscope carrier in proving installation needs to transport test strip, proving installation door is opened, and handled easily person deposits or takes out test paper.Described baffle plate plays good protection to the test strips microscope carrier in proving installation and light source transmitter-receiver device, makes microscope carrier and light source transmitter-receiver device from external force collision, and can prevent dust pollution.Simultaneously when proving installation is by whole taking out, reagent residual on microscope carrier or sample can not be exposed in external environment, prevent the pollution to environment.
Light source transmitter-receiver device 103 comprises the preferred stepper motor of electro-motor 130(promoting light source transmitter-receiver device and move up and down), light source emitter 131.Light source transmitter-receiver device 103 also comprises the optical coupled switch 132 controlling light supply apparatus movement position, and described smooth lotus root switch 132 is electrically connected with described electro-motor 130, runs for controlling described electro-motor 130 and brakes.Described smooth lotus root switch 132 has lightening hole 133, and light source transmitter-receiver device has shutter 134.Described shutter 134 has relative to lightening hole 133 and blocks lightening hole 133 and leave lightening hole 133 two positions.When in the downward operational process of light source transmitter-receiver device, when shutter 134 is positioned at above the lightening hole 133 of light lotus root switch 132, now light path is unimpeded, and power supply keeps power supply state always, and light supply apparatus continues to move downward under electro-motor 130 rotates.When shutter 134 blocks the lightening hole 133 of light lotus root switch 132, light path is cut off, thus closes the power supply of electro-motor 130, and light supply apparatus is no longer descending, opens sample detection light source 131 pairs of samples simultaneously and carries out determination and analysis.
Each proving installation 100 can also comprise independently microprocessor, can perform and include but not limited to such as control light source emitter, the movement position monitoring pallet, test environment temperature and heating plate heating supervisor, and outwardly transmit data by data transmission interface.
Proving installation 100 also can comprise power interface and data transmission interface, realizes powering and test transmission result to proving installation.Proving installation 100 also can with integrated electric connector 140.Described electric connector is device power interface and data transmission interface integrated, and this just makes proving installation have more space to deposit other accessories, decreases the operation of production, enhances productivity.Proving installation is connected with master control set by electric connector, accepts master control set and powers to proving installation, or transfers data to the data output device of master control set.The electric connector of proving installation also can be connected on other data output device.
The detection light source that each proving installation adopts can be identical or different.When the detection light source that multiple proving installation adopts is identical, speed and the efficiency of detection can be improved.If the detection light source that proving installation adopts is different, each proving installation can measure the identical or different biochemical parameter of identical or different sample, thus realizes a tractor serves several purposes.Array mode between other any master control sets and proving installation is all suitable.
In order to ensure that proving installation is well fixed on master control set, the buckle structure be fixed to by proving installation on master control set can be set on proving installation and master control set.Described buckle structure can be the fixed form of screw thread snap close (such as bolt and nut, screw and threaded hole), buckle snap close or magnetic patch snap close.The structure of described magnetic patch snap close, as shown in Figure 10 to Figure 13, comprises at least three magnetic patch, the first magnetic patch 151, second magnetic patch 152 and the 3rd magnetic patch 153.First magnetic patch 151 designs on a first device, and the second magnetic patch 152 and the 3rd magnetic patch 153 design on the second device.The magnetic in two faces that the first magnetic patch 151 is relative with the second magnetic patch 152 is different (being respectively S pole and N pole), and the Magnetic Phase in two faces that the second magnetic patch 152 is relative with the 3rd magnet 153 is with (be all S pole or be all N pole).First magnetic patch 151, second magnetic patch 152 and the 3rd magnetic patch 153 are roughly overlapping perpendicular to the projection on the direction of its opposite face.If when two mutual snap closes of device will be lived, push the first device with the first magnetic patch 151 with the second magnetic patch 152 to the second device is close, first device and the second device are eventually through together with magnetic-adsorption, and now, the 3rd magnetic patch 153 is away from the second magnetic patch 152.If two devices will be separated from each other, now push the 3rd magnetic patch 153 to second magnetic patch 152 close, utilize the mutual repulsive force between the 3rd magnetic patch 153 and the second magnetic patch 152 and the first magnetic patch 151, weaken the magnetic attraction between the first magnetic patch 151 and the second magnetic patch 153, thus first device and the second device are separated from each other.
In the embodiment of Biochemical Analyzer of the present invention as shown in Figure 10 to Figure 11, the first magnetic patch 151 designs on the backboard 126 of proving installation 100.Second magnetic patch 152 is entrenched in the bonnet lock hole 22 of master control set 10.Master control set bonnet is designed with two bracing frames 154, and support frame as described above 154 designs the both sides at bonnet lock hole respectively.3rd magnetic patch 153 is connected with bracing frame 154 by spring leaf 155.The magnetic in two faces that the first magnetic patch 151 is relative with the second magnetic patch 152 is different (being respectively S pole and N pole), and the Magnetic Phase in two faces that the second magnetic patch 152 is relative with the 3rd magnetic patch 153 is with (be all S pole or be all N pole).Shown in Figure 10 is the state that proving installation 100 is pushed in the storage chamber 15 of master control set 10, now, there is a natural attraction between the sexes because of magnet for first magnetic patch 151 and the second magnetic patch 152, and this magnetic attraction makes proving installation be inhaled on master control set firmly, and can not skid off from master control set.As shown in figure 11, when proving installation 100 extracted out by needs, 3rd magnetic patch 153 is pushed away to the second magnetic patch direction, because the polarity in two faces that the second magnetic patch 152 is relative with the 3rd magnetic patch 153 is identical, and the polarity in the face that the 3rd magnetic patch 153 is relative with the first magnetic patch 151 is also identical, according to the principle of the two like magnetic poles repel each other of magnet, the 3rd magnetic patch 153 has a repulsive interaction to the first magnetic patch and the second magnetic patch, weakens the magnetic attraction between the first magnetic patch 151 and the second magnetic patch 152.Close along with the 3rd magnetic patch 153, this repulsive force can magnetic attraction between basic neutralisation first magnetic patch 151 and the second magnetic patch 152.Thus proving installation 100 just can be extracted out by from the storage chamber of master control set easily.
Figure 12 is the another kind of embodiment of magnetic block lock catch structure, and the 3rd magnetic patch 153 can be slided on slide bar 156 by slide bar button 157.Figure 13 is the another kind of embodiment of magnetic block lock catch structure, and the 3rd magnetic patch 153 is conflicted mutually by snak link 159 and spring 158, and spring has the state compressed by the 3rd magnetic patch and unfold.
Between master control set and proving installation, testing process as shown in figure 14.Workflow is: first opening power, Biochemical Analyzer is started shooting and is entered startup self-detection program, after startup self-detection terminates, enters preheating program, when the probe temperature of Biochemical Analyzer meets the temperature range preset, detector is in wait test mode, and operator selects the proving installation needing to carry out testing, after putting into test paper bar, analyser starts test, after test terminates, output test result, take out test paper bar.If the detection of next sample also will be carried out, again put into new test paper bar, start the mensuration of a new round.If all samples has been tested all, then shut down.
It is below another embodiment of the present invention.
As shown in Figure 15 to 21, biochemical analysis tester 1a, comprises main control unit 50a and at least two the test cell 100a be arranged in casing 2a.Casing corresponds to each test cell 100a test cell door 3a is installed.
Main control unit 50a is connected by the mode such as data line, electric wire with the total power switch of biochemical analysis tester 1a, data input/output control system and test cell 100a respectively.Data I/O comprises liquid crystal display 4a, USB interface, data line interface and printer etc.
Test cell 100a comprises sample conveying device 110a and testing light source device 111a.
The sample conveying device 110a of test cell 100a comprises the pallet 114a that carrying detects test paper, has a heat transfer plate 115a, by this heat transfer plate, the heat that heating arrangement 116a produces is delivered to surveyed area in the below of pallet.Described heating arrangement 116a can be selected from the electric elements such as power resistor plate.Placed one piece of lower lock block thermal insulation board 117a in the below of temperature-adjusting heating device 116a, the heat that heating arrangement produces is intercepted at this, no longer transmits toward other positions.Electro-motor 118a is fixed on electro-motor fixed head 119a.When electro-motor is opened, promote plate nut and move up and down.Detection experiment bar is delivered to the detection position preset by sample conveying device 110a by pallet 114a, control pallet 114a arrive the detection position preset preferably by optical coupled switch 121a.Described optical coupled switch 121a has lightening hole 122a, and described pallet 114a has lower limb 123a and is positioned at above described lightening hole 122a.Described lower limb 123a has relative to lightening hole 122a and blocks lightening hole 122a and leave lightening hole 122a two positions.When the lower limb 123a of pallet 114a is positioned at above the lightening hole 122a of optical coupled switch 121a, then light path is unimpeded, and now electro-motor power supply keeps power supply state always.Under electro-motor 118a rotates, pallet 114a continues to move upward.After pallet 114a continues to rise and touches detection light source device 112a, because detection light source device 112a maintains static, pallet just can not continue to move ahead, and light supply apparatus can produce pallet 114a and continue downward pressure.But optical coupled switch is also continuing to move upward under the drive of electro-motor, until the lower limb 123a of pallet 114a blocks the lightening hole 122a of optical coupled switch 121a.After lightening hole is blocked, light path is just cut-off, thus closes the power supply of electro-motor.Now, detect test paper and reached detection position, the analysis that sample detection light supply apparatus 112a carries out sample opened by biochemical analysis tester.
Described testing light source device 111a comprises testing light source 112a and upper holder block 113a.Be equipped with for producing pressure to described detection test paper described upper holder block 113a and described lower extrusion plate 117a.In a specific embodiment of the present invention, pressure is generally 1kgf/cm
2-3kgf/cm
2, be preferably 2 kgf/cm
2.Described light supply apparatus has the effect of two aspects at least: 1) light is imported into the conversion zone to detecting test paper, and receive the reflected light of reaction zone.2) test zone to pallet transmits light, and receives reflected light information, and reflected light information is supplied to system, first-class to be tested in order to judge whether detection test paper has been placed on test paper carrier bench.
The magnetic induction start device of biochemical analysis tester open detection is also provided with in test cell.The magnetic induction signal that magnetic induction start device produces is connected on main control unit.In one embodiment, magnetic induction start device comprises the magnetic induction switch 10a be arranged in test cell and the magnetic patch 11a be arranged on the cell gate of test cell, and its material is selected from magnet steel, and magnet is worked as.When cell gate cuts out, magnetic induction switch 10a senses the field signal of magnetic patch on cell gate, and after field signal is delivered to main control unit, main control unit judges the particular location of cell gate, whether such as cell gate is closed or open, thus by main control unit to whether start detection judges.
On the other hand, the material of biochemical analysis tester casing chosen from Fe or steel etc. can produce the material of absorption affinity with magnetic patch, or in test cell, install an iron block etc.When test cell door is closed, by the magneticaction of contact point magnet, cell gate can be pull-in on the casing of main frame, thus realize the sealed of cell gate by magnetic patch firmly that be arranged on cell gate.Therefore biochemical analysis tester does not need the unit lock locking device adding other again.
The modes such as magnetic patch is fixed with viscose or screw is fixing are fixed on cell gate.Magnetic patch can be closed in cell gate or be placed on outside cell gate.
The casing 2a of analysis tester is also equipped with test paper application of sample operator's console 5a.When adding sample, test paper can temporarily leave on described test paper operator's console 5a.Operator's console is a card trench structure in one embodiment, and described operator's console is made up of upper plate 6a and lower plate 7a, and leaves gap 8a between upper plate and lower plate, and described gap spacing is just in time the thickness or larger than test paper thickness a little of test paper.The fore-end of test paper is blocked in the gap of operator's console, and the application of sample position of test paper and the place of being affectedly bashful are all in the outside of operator's console, and the bottom surface of test paper being affectedly bashful position does not touch experiment desktop.Very convenient like this operator's application of sample and pick up test paper.When application of sample, first test paper is stuck in the draw-in groove of operator's console by operator, then carries out application of sample.Due to test paper be affectedly bashful part be high up in the air, after adding sample, operator can pick up the test paper being added with sample easily, is put in the detection platform of test cell by this test paper.Described test paper operator's console can be arranged on the below of test cell door, side or top.
In embodiment as shown in figure 20, described biochemical analysis tester comprises a main control unit and three independently test cell.Main control unit is connected with power supply, printer, display system, USB interface, Parameters Input Unit etc.Main control unit is also connected with three test cells respectively.Test cell independently completes respective detection, and test result is transferred to main control unit, by main control unit output detections result.Test cell comprises baffled photometer, mechanical driving device and temperature control equipment etc.
Biochemical analysis method of testing as described in Figure 21, comprising:
1) Biochemical Analyzer tester is opened, and test parameter is set, described biochemical analysis tester comprises main control unit and at least two separate test cells, main control unit is interconnected with analyser power control switch, data output device, input control system and test cell respectively, and each test cell comprises sample conveying device 110a and testing light source device 111a.
2) test paper adding sample is put into one of them test cell.
3) biochemical analysis tester judges whether detection zone has test paper to exist, if do not have, biochemical analysis tester provides the information reapposing test paper.
4) biochemical analysis tester judges whether test cell door closes, if do not have, biochemical analysis tester provides the information of closing unit door.
5) when test paper Already in detection zone and cell gate closed these two groups of information all possess time, biochemical analysis tester starts start detection and output detections result.
In one embodiment, biochemical analysis tester is after receiving test paper Already in these two groups of information closed by detection zone and cell gate, and whether also just can detect the start time exceedes the time of presetting and judge.If overtime, then biochemical analysis tester provides the information again changing test paper.If not overtime, biochemical analysis tester starts start detection and output detections result.
In test process, each test cell independently detects, and does not interfere with each other, thus improves test speed, can detect more sample at one time.
Biochemical analysis tester utilizes the light supply apparatus of test cell to come interpretation detection zone and whether placed test paper.Testing light source sends test light, and judges whether detection zone has test paper to exist by the reflected light information of pallet detection zone.If no, biochemical analysis tester provides the information reapposing test paper.
By magnetic induction signal, biochemical analysis tester judges whether test cell door is shut.When cell gate cuts out, magnetic induction switch 10a senses the field signal of magnetic patch on cell gate, and after field signal is delivered to main control unit, main control unit judges the particular location of cell gate, such as whether close or open, thus by main control unit to whether start detection judges.
Biochemical Analyzer of the present invention and method of testing can be used for the detection of a series of physiological and biochemical index such as glucose, cholesterol, high density fat is sour, low density fat is sour, triglyceride, uric acid, cholerythrin, total protein, haemoglobin, ketoboidies.
Claims (6)
1. a biological sample analysis tester, comprise main control unit and at least two separate test cells, main control unit is interconnected with general supply gauge tap, data input/output control system and test cell respectively, each test cell at least comprises sample conveying device and light supply apparatus, described light supply apparatus comprises testing light source and top board, sample conveying device comprises test paper pallet, the electro-motor of push to test test paper tray motion and the switch of control test paper pallet arrival detection position, and described test paper pallet is provided with heating arrangement.
2. analysis tester according to claim 1, it is characterized in that, this biochemical analysis tester corresponds to each test cell and is equipped with a test cell door, and the test cell that the operation of closing certain test cell door can start corresponding to it automatically carries out work.
3. analysis tester according to claim 2, is characterized in that, in each test cell, be provided with magnetic induction start device, and this magnetic induction start device comprises the magnetic patch be arranged on test cell door and the magnetic induction switch be arranged in test cell.
4. analysis tester according to claim 1, is characterized in that, this biochemical analysis tester comprises the casing for fixing main control unit and test cell, this casing is equipped with test paper application of sample operator's console.
5. analysis tester according to claim 4, is characterized in that, test paper operator's console is the structure of a draw-in groove, comprises upper plate and lower plate, leaves gap and insert with being applicable to test paper between upper plate and lower plate.
6. analysis tester according to claim 1, is characterized in that, it is optical coupled switch that described control test paper pallet arrives the switch detecting position.
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| CN201510243006.6A CN104897912B (en) | 2012-08-24 | 2012-08-24 | biological sample analysis tester |
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| CN201510243006.6A CN104897912B (en) | 2012-08-24 | 2012-08-24 | biological sample analysis tester |
| CN201210304580.4A CN102901833B (en) | 2011-09-21 | 2012-08-24 | Biochemical analysis tester and testing method |
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