CN104689036B - A kind of preparation method for treating cold in children and repeated cold oral liquid - Google Patents
A kind of preparation method for treating cold in children and repeated cold oral liquid Download PDFInfo
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Abstract
The invention belongs to the field of Chinese medicines, more particularly to a kind of preparation method for treating cold in children and repeated cold oral liquid.The preparation method is that first by chrysanthemum indicum and root of purple-flowered peucedanum distillation extraction volatile matter, American Ginseng, Chinese ephedra and fritillaria are subjected to alcohol extracting, and filtered using milipore filter, then remaining beggar-ticks, the Radix Astragali, Radix Isatidis, radix glycyrrhizae, mushroom and the above step dregs of a decoction are mixed into water-filling to carry, and filtered using milipore filter, filtered after adjusting pH value again by tubular ultra-filtration membrane equipment, sterilizing.The preparation method of the present invention can effectively extract the volatility effective component of chrysanthemum indicum and the root of purple-flowered peucedanum, and alcohol precipitation process is reduced using ultrafiltration membrance filter, reduce the dosage of ethanol in production, improve processing safety and shorten the production cycle, improve the efficiency of production, the content of the active ingredient of oral liquid is greatly improved, the stability ensured drug quality, is advantageous to the industrialized production and application of the treatment cold in children and the preparation method of repeated cold oral liquid.
Description
Technical field
The invention belongs to the field of Chinese medicines, more particularly to a kind of preparation side for treating cold in children and repeated cold oral liquid
Method.
Background technology
With the fast development of society, there occurs larger change, plus modern through deficient exercises, body for amblent air temperature
Qualitative change is poor, and the flu incidence of disease is gradually increasing.Because child physical endowment is weak, susceptible cold-evil, and due to the body that children are young sun, cloudy gas
Do not win, yang-energy is weak, and body does not fill, and the flesh natural fibre line of meat is dredged thin, and outer gas function is not solid；Or because other reasonses cause the positive unsaturated vapor of children without
Can be imperial evil, so flu is fallen ill repeatedly, the flu incidence of disease remains high always.
The medicine for the treatment of cold in children is many at present, including oral liquid, Western medicine, decoction and electuary etc., but because small
Youngster's physiological development is immature and takes medicine the reason for more difficult, so should make every effort to that application dose is small, curative effect is high in prescriptions
Drug therapy.Western medicine mainly mitigates nasal obstruction sense, reduces nasal discharge, keeps Eustachian tube and sinus mouth unimpeded, prevents scabies secondary infection
The effect of, but because flu morbidity is rapid, complicated symptoms are various, and toxic side effect is larger, therefore so far without a kind of medicine
Thing can effectively treat the flu problem of children.
Chinese patent CN100344313, which is disclosed, a kind of treats cold in children and the Chinese patent drug of repeated cold and its preparation side
Method, the Chinese medicine prescription be 12 parts of beggar-ticks, 8 parts of chrysanthemum indicum, 2 parts of American Ginseng, 30 parts of the Radix Astragali, 20 parts of Radix Isatidis, 6 parts of the root of purple-flowered peucedanum,
4 parts of fritillaria, 2 parts of Chinese ephedra, 6 parts of radix glycyrrhizae, 10 parts of mushroom, 20 parts of honey, the principle of reatment of the oral liquid are：QI invigorating dredges table, heat-clearing
Removing toxic substances, relieving cough and asthma, righting is taken into account with eliminating evil, and children's body is not filled, the flesh natural fibre line of meat dredge it is thin, defend outer function do not consolidate, be subject to extraneous gas
The change of time, the reason for being not yet applicable very well, have significant therapeutic effect.
But the preparation method of the Chinese patent drug for the treatment of cold in children and repeated cold is that the root of purple-flowered peucedanum is directly carried out into water extraction, is caused
Volatile oil can not be collected, and active ingredient is lost.Starch in Chinese medicine extract, natural gum, more is removed using water extraction and alcohol precipitation method simultaneously
The impurity such as sugar, matter of mixing, protein, and ensure the clarity of solution, still, in actual production, due to extract solution dosage compared with
Greatly, ethanol requirement is larger, causes manufacturing cost to raise, and alcohol precipitation concentration requires higher, and ethyl alcohol boiling point is relatively low, peace be present
The problem of full property difference, and alcohol precipitation process cycle are longer, cause the extension in whole production technology cycle, so as to add production
Cost.Meanwhile the Chinese ephedra of the technique is again by the Chinese ephedra dregs of a decoction and the dregs of a decoction of other medicinal materials after first being extracted using 70%-85% ethanol
Carry out water extraction together, due to Aqueous extracts carry out the impurity molecule amounts such as the starch of alcohol precipitation removing, natural gum, polysaccharide, tannin, protein compared with
Greatly, and during alcohol precipitation sticking sediment and dough are easily formed, the active ingredient in Aqueous extracts is wrapped up
Enter, cause active ingredient to be removed in the lump with the step of filtering, cause the reduction of active ingredient in filtrate, have impact on preparation
Drug effect.It is unfavorable for industrialized production and the application of the preparation technology.
The content of the invention
High in order to solve the preparation technology cost of prior art treatment cold in children medicine, the production cycle is grown, active ingredient
The problem of percentage allocation is low, present invention aims at provide a kind of preparation side for the oral liquid for treating cold in children and repeated cold
Method.
The preparation method for the treatment of cold in children provided by the invention and repeated cold oral liquid, comprises the following steps：
（1）Weigh 12 parts of beggar-ticks, 8 parts of chrysanthemum indicum, 2 parts of American Ginseng, 30 parts of the Radix Astragali, 20 parts of Radix Isatidis, 6 parts of the root of purple-flowered peucedanum, shellfish
20 parts of female 4 parts, 2 parts of Chinese ephedra, 6 parts of radix glycyrrhizae, 10 parts of mushroom and honey are standby；
（2）The chrysanthemum indicum and the root of purple-flowered peucedanum of above-mentioned parts by weight are taken, adds 5-10 times of the distilled water of both gross weights, vapor steams
1.5-5 hours are evaporated, by gained volatile oil and distillate by volume 1:1 collects, and then adds solubilizer, is volatilized after mixing
Thing, save backup, it is standby after dregs of a decoction filtering；
（3）Take the American Ginseng of above-mentioned parts by weight to crush, add the 60%-80% of 5-10 times of American Ginseng weight ethanol, heating
Twice, each 1.5-3 hours, filtering, the dregs of a decoction are standby for refluxing extraction, merge extract solution, extract solution is passed through into ultrafiltration membrance filter, mistake
Stress control is filtered in 0.1-0.4MPa, temperature control collects filtrate at 15-80 DEG C, and be concentrated under reduced pressure recovery ethanol, and it is dense to obtain American Ginseng
Contracting liquid is standby；
（4）The Chinese ephedra and fritillaria of above-mentioned parts by weight are taken, 5-10 times of the 70%-85% of both gross weights ethanol is added, adds
Twice, each 1-2 hours, filtering, the dregs of a decoction are standby for circumfluence distillation, merge extract solution, extract solution is passed through into ultrafiltration membrance filter, mistake
Stress control is filtered in 0.1-0.4MPa, temperature control collects filtrate at 15-80 DEG C, and be concentrated under reduced pressure recovery ethanol, obtains Chinese ephedra and shellfish
Female concentrate is standby；
（5）The beggar-ticks of above-mentioned parts by weight, the Radix Astragali, Radix Isatidis, radix glycyrrhizae, mushroom are taken, with step（2）、（3）With（4）Medicine
Slag mixes, and adds the water of 5-10 times of medicinal material gross weight, decocts twice, each 1.5-3 hours, collecting decoction, decocting liquid is passed through super
Membrane filtration, filter pressure are controlled in 0.1-0.4MPa, and temperature control collects filtrate at 15-80 DEG C, and be concentrated under reduced pressure recovery second
Alcohol, it is standby to obtain mixed concentrated liquid；
（6）By step（2）Obtained volatile matter and step（3）~（5）Obtained concentrate mixes, and adds honey, stirs
It is even, mixed liquor is obtained, mixed liquor pH value is adjusted to 4.0-6.5 with 1%-10% NaoH solution, mixed liquor is passed through into tubular type ultrafiltration
Film device filters, molecular cut off 5000-200000, filter pressure 0.1-0.4MPa, 0-40 DEG C of filtration temperature, membrane flux
For 50-250L/m3H, filtrate add water to ormal weight, sterilizing, produce.
The preparation method step of the treatment cold in children of the present invention and the oral liquid of repeated cold（2）Solubilizer be preferably
Poly- sorb fat 80.
In addition, described step（3）And step（4）In the aperture of milipore filter be 20nm-200nm, the aperture of milipore filter
More preferably 100nm-200nm.Described step（3）And step（4）In filter pressure further control in 0.2-
0.3MPa, temperature are further controlled at 25-60 DEG C.
Wherein, described step（5）Middle membrane aperture is molecular cut off 5000-200000, more preferably 10000-
200000。
Further, described step（5）Middle filter pressure is preferably 0.2-0.3MPa, and preferably filtration temperature is preferred
10-38℃。
Further, described step（5）Middle membrane flux is preferably 100-200L/m3•h。
Volatile oil and small molecule cumarin are one of effective active compositions of the root of purple-flowered peucedanum, wherein volatile oil and small molecule cumarin
With volatility, traditional handicraft is that the root of purple-flowered peucedanum is directly carried out into water extraction, causes volatile oil and small molecule cumarin not to collect, leads
The loss of active ingredient is caused, and the technique of the present invention is to be changed to the root of purple-flowered peucedanum with first being volatilized with extraction by steam distillation by water extraction
Property material after again by the dregs of a decoction carry out water extraction method, can preferably retain the active ingredient of the root of purple-flowered peucedanum, improve the effective of oral liquid
The content of composition.
The present invention instead of traditional alcohol precipitation separation impurity technology using Ultra filtration membrane impurity technology, and milipore filter not only may be used
To remove big molecular impurity, but also can be by the active ingredients such as ephedrine hydrochloride and pseudoephedrine hydrochloride and big molecular impurity point
From avoiding ephedrine hydrochloride and pseudoephedrine hydrochloride be wrapped in because being lost in the impurity that alcohol precipitation is formed, active ingredient is protected
Stay.Meanwhile the dosage of ethanol in production is substantially reduced, improve processing safety and shorten the production cycle, improve the effect of production
Rate, reduce production cost.
Step of the present invention（5）In after pH value is adjusted, mixed solution is filtered by tubular ultra-filtration membrane equipment, can be effective
PH is adjusted after cause changes in solubility because solution environmental changes and produce precipitation or indissoluble thing filters off, improve decoction
Clarity, so as to the stability ensured drug quality.
In a word, compared with prior art, present invention treatment cold in children and the preparation method of repeated cold oral liquid have
Following advantage：
1）Present invention treatment cold in children and the preparation method of repeated cold oral liquid reduce alcohol precipitation process, substantially reduce life
The dosage of ethanol in production, improve processing safety and shorten the production cycle, improve the efficiency of production, reduce production cost；
2）It is effective that present invention treatment cold in children and the preparation method of repeated cold oral liquid can effectively reduce crude drug
The volatilization and loss of composition, greatly improve the content of the active ingredient of oral liquid；
3）Present invention treatment cold in children and the preparation method of repeated cold oral liquid use ultrafiltration membrance filter method, can be with
Impurity and sediment or indissoluble thing are efficiently separated, the clarity of decoction is improved, so as to the stability ensured drug quality.
Case is embodied
The present invention is further illustrated below by way of specific embodiment, but those skilled in the art should know the tool of the present invention
Body embodiment is not limit the invention in any way, and any equivalent substitution made on the basis of the present invention each falls within this
The protection domain of invention.
The preparation method of embodiment 1, present invention treatment cold in children and repeated cold oral liquid
（1）Weigh 12 parts of beggar-ticks, 8 parts of chrysanthemum indicum, 2 parts of American Ginseng, 30 parts of the Radix Astragali, 20 parts of Radix Isatidis, 6 parts of the root of purple-flowered peucedanum, shellfish
20 parts of female 4 parts, 2 parts of Chinese ephedra, 6 parts of radix glycyrrhizae, 10 parts of mushroom and honey are standby；
（2）The chrysanthemum indicum and the root of purple-flowered peucedanum of above-mentioned parts by weight are taken, adds 5 times of the distilled water of both gross weights, steam distillation
1.5 hours, by gained volatile oil and distillate by volume 1:1 collects, and then adds poly- sorb fat 80, is volatilized after mixing
Thing, save backup, it is standby after dregs of a decoction filtering；
（3）Take the American Ginseng of above-mentioned parts by weight to crush, add 60% ethanol of 5 times of American Ginseng weight, heating and refluxing extraction
Twice, every time 1.5 hours, filtering, the dregs of a decoction were standby, merged extract solution, and extract solution is passed through into ultrafiltration membrance filter, filter pressure control
In 0.1MPa, temperature control collects filtrate at 25 DEG C, and be concentrated under reduced pressure recovery ethanol, and it is standby to obtain American Ginseng concentrate；
（4）The Chinese ephedra and fritillaria of above-mentioned parts by weight are taken, 5 times of 70% ethanol of both gross weights is added, is heated to reflux carrying
Take twice, 1 hour every time, filter, the dregs of a decoction are standby, merge extract solution, and extract solution is passed through into ultrafiltration membrance filter, filter pressure control
In 0.1MPa, temperature control collects filtrate at 25 DEG C, and be concentrated under reduced pressure recovery ethanol, obtains Chinese ephedra and fritillaria concentrate is standby；
（5）The beggar-ticks of above-mentioned parts by weight, the Radix Astragali, Radix Isatidis, radix glycyrrhizae, mushroom are taken, with step（2）、（3）With（4）Medicine
Slag mixes, and adds the water of 5 times of medicinal material gross weight, decocts twice, 1.5 hours every time, collecting decoction, decocting liquid is passed through into milipore filter mistake
Filter, filter pressure are controlled in 0.1MPa, and temperature control collects filtrate at 25 DEG C, and be concentrated under reduced pressure recovery ethanol, obtains mixed concentrated liquid
It is standby；
（6）By step（2）Obtained volatile matter and step（3）~（5）Obtained concentrate mixes, and adds honey, stirs
It is even, mixed liquor is obtained, mixed liquor pH value is adjusted to 4.0 with 3%NaoH solution, mixed liquor is filtered by tubular ultra-filtration membrane equipment,
Molecular cut off is 5000-200000, filter pressure 0.1MPa, 10 DEG C of filtration temperature, membrane flux 50-250L/m3H, filter
Liquid adds water to ormal weight, sterilizing, produces.
The preparation method of embodiment 2, present invention treatment cold in children and repeated cold oral liquid
（1）Weigh 12 parts of beggar-ticks, 8 parts of chrysanthemum indicum, 2 parts of American Ginseng, 30 parts of the Radix Astragali, 20 parts of Radix Isatidis, 6 parts of the root of purple-flowered peucedanum, shellfish
20 parts of female 4 parts, 2 parts of Chinese ephedra, 6 parts of radix glycyrrhizae, 10 parts of mushroom and honey are standby；
（2）The chrysanthemum indicum and the root of purple-flowered peucedanum of above-mentioned parts by weight are taken, adds 8 times of the distilled water of both gross weights, steam distillation 3
Hour, by gained volatile oil and distillate by volume 1:1 collects, and then adds poly- sorb fat 80, volatile matter is obtained after mixing,
Save backup, it is standby after dregs of a decoction filtering；
（3）Take the American Ginseng of above-mentioned parts by weight to crush, add 70% ethanol of 8 times of American Ginseng weight, heating and refluxing extraction
Twice, every time 2 hours, filtering, the dregs of a decoction were standby, merged extract solution, and extract solution is existed by ultrafiltration membrance filter, filter pressure control
0.3MPa, temperature control collect filtrate at 50 DEG C, and be concentrated under reduced pressure recovery ethanol, and it is standby to obtain American Ginseng concentrate；
（4）The Chinese ephedra and fritillaria of above-mentioned parts by weight are taken, 8 times of 75% ethanol of both gross weights is added, is heated to reflux carrying
Take twice, 1.5 hours every time, filter, the dregs of a decoction are standby, merge extract solution, extract solution is passed through into ultrafiltration membrance filter, filter pressure control
For system in 0.3MPa, temperature control collects filtrate at 50 DEG C, and be concentrated under reduced pressure recovery ethanol, obtains Chinese ephedra and fritillaria concentrate is standby；
（5）The beggar-ticks of above-mentioned parts by weight, the Radix Astragali, Radix Isatidis, radix glycyrrhizae, mushroom are taken, with step（2）、（3）With（4）Medicine
Slag mixes, and adds the water of 8 times of medicinal material gross weight, decocts twice, 2 hours every time, collecting decoction, decocting liquid is passed through into milipore filter mistake
Filter, filter pressure are controlled in 0.3MPa, and temperature control collects filtrate at 50 DEG C, and be concentrated under reduced pressure recovery ethanol, obtains mixed concentrated liquid
It is standby；
（6）By step（2）Obtained volatile matter and step（3）~（5）Obtained concentrate mixes, and adds honey, stirs
It is even, mixed liquor is obtained, mixed liquor pH value is adjusted to 6 with 5%NaoH solution, mixed liquor is filtered by tubular ultra-filtration membrane equipment, cut
It is 10000-200000 to stay molecular weight, filter pressure 0.3MPa, 30 DEG C of filtration temperature, membrane flux 100-200L/m3H, filter
Liquid adds water to ormal weight, sterilizing, produces.
The preparation method of embodiment 3, present invention treatment cold in children and repeated cold oral liquid
（1）Weigh 12 parts of beggar-ticks, 8 parts of chrysanthemum indicum, 2 parts of American Ginseng, 30 parts of the Radix Astragali, 20 parts of Radix Isatidis, 6 parts of the root of purple-flowered peucedanum, shellfish
20 parts of female 4 parts, 2 parts of Chinese ephedra, 6 parts of radix glycyrrhizae, 10 parts of mushroom and honey are standby；
（2）The chrysanthemum indicum and the root of purple-flowered peucedanum of above-mentioned parts by weight are taken, adds 10 times of the distilled water of both gross weights, steam distillation
5 hours, by gained volatile oil and distillate by volume 1:1 collects, and then adds poly- sorb fat 80, is volatilized after mixing
Thing, save backup, it is standby after dregs of a decoction filtering；
（3）Take the American Ginseng of above-mentioned parts by weight to crush, add 80% ethanol of 10 times of American Ginseng weight, be heated to reflux carrying
Take twice, 3 hours every time, filter, the dregs of a decoction are standby, merge extract solution, and extract solution is passed through into ultrafiltration membrance filter, filter pressure control
In 0.4MPa, temperature control collects filtrate at 60 DEG C, and be concentrated under reduced pressure recovery ethanol, and it is standby to obtain American Ginseng concentrate；
（4）The Chinese ephedra and fritillaria of above-mentioned parts by weight are taken, 10 times of 85% ethanol of both gross weights is added, is heated to reflux
Twice, 2 hours every time, filtering, the dregs of a decoction were standby, merge extract solution, extract solution is passed through into ultrafiltration membrance filter, filter pressure control for extraction
For system in 0.4MPa, temperature control collects filtrate at 60 DEG C, and be concentrated under reduced pressure recovery ethanol, obtains Chinese ephedra and fritillaria concentrate is standby；
（5）The beggar-ticks of above-mentioned parts by weight, the Radix Astragali, Radix Isatidis, radix glycyrrhizae, mushroom are taken, with step（2）、（3）With（4）Medicine
Slag mixes, and adds the water of 10 times of medicinal material gross weight, decocts twice, 3 hours every time, collecting decoction, decocting liquid is passed through into milipore filter mistake
Filter, filter pressure are controlled in 0.4MPa, and temperature control collects filtrate at 60 DEG C, and be concentrated under reduced pressure recovery ethanol, obtains mixed concentrated liquid
It is standby；
（6）By step（2）Obtained volatile matter and step（3）~（5）Obtained concentrate mixes, and adds honey, stirs
It is even, mixed liquor is obtained, mixed liquor pH value is adjusted to 6.5 with 10%NaoH solution, mixed liquor is passed through into tubular ultra-filtration membrane equipment mistake
Filter, molecular cut off 5000-200000, filter pressure 0.4MPa, 40 DEG C of filtration temperature, membrane flux 50-250L/m3•
H, filtrate add water to ormal weight, sterilizing, produce.
Comparative example 4, a kind of preparation method for treating cold in children and repeated cold oral liquid
Prescription：
12 parts of beggar-ticks, 8 parts of chrysanthemum indicum, 2 parts of American Ginseng, 30 parts of the Radix Astragali, 20 parts of Radix Isatidis, 6 parts of the root of purple-flowered peucedanum, 4 parts of fritillaria, fiber crops
Yellow 2 parts, 6 parts of radix glycyrrhizae, 10 parts of mushroom；
The preparation technology of preparation technology such as Chinese patent CN100344313 embodiments 1.
The oral liquid contrast test that test example 1,1-3 of the embodiment of the present invention are prepared with comparative example 4：
Using high performance liquid chromatography（One annex VI D of Chinese Pharmacopoeia version in 2010）Determine embodiment 1-3 and contrast
The ephedrine hydrochloride of oral liquid and the content of pseudoephedrine hydrochloride prepared by example 4, collects embodiment 1-3 and prepared by comparative example 4
The volatile matter of journey, the quality for the volatile matter that makes to weigh with scale, specific test data are as follows：
The oral liquid contrast test data that table 1, embodiments of the invention 1-3 are prepared with comparative example 4：
| Index | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 4 |
| Ephedrine hydrochloride（Mg/ bottles） | 0.6595 | 0.8056 | 0.6695 | 0.5838 |
| Pseudoephedrine hydrochloride（Mg/ bottles） | 0.4110 | 0.5610 | 0.4310 | 0.3507 |
| Volatile matter（kg） | 3.1 | 4.1 | 3.3 | 1.9 |
From the test data of table 1：
1）Waved by the ephedrine hydrochloride of the embodiment 1-3 oral liquids prepared and the content of pseudoephedrine hydrochloride with what is collected
The weight of stimulating food understands that the preparation technology of embodiment 2 can greatly improve the content of ephedrine hydrochloride and pseudoephedrine hydrochloride,
Increase weight of the volatile matter, be advantageous to industrialized production and the application of the preparation；
2）Embodiment 1-3 compared with comparative example 4, the present invention using milipore filter by ephedrine hydrochloride and pseudoephedrine hydrochloride with
Macromolecular separation replaces alcohol precipitation separation impurity technology, can effectively reduce ephedrine hydrochloride and pseudoephedrine hydrochloride active ingredient
Loss；
3）Embodiment 1-3 is compared with comparative example 4, after the root of purple-flowered peucedanum is first used extraction by steam distillation volatile materials by the present invention
The root of purple-flowered peucedanum is directly carried out water extraction by the method that the dregs of a decoction are carried out to water extraction again instead of traditional handicraft, can preferably retain the effective of the root of purple-flowered peucedanum
Composition, improve the content of the active ingredient of oral liquid.
Claims (2)
1. a kind of preparation method for treating cold in children and repeated cold oral liquid, it is characterised in that comprise the following steps：
(1) 12 parts of beggar-ticks, 8 parts of chrysanthemum indicum, 2 parts of American Ginseng, 30 parts of the Radix Astragali, 20 parts of Radix Isatidis, 6 parts of the root of purple-flowered peucedanum, fritillaria 4 are weighed
20 parts of part, 2 parts of Chinese ephedra, 6 parts of radix glycyrrhizae, 10 parts of mushroom and honey are standby；
(2) chrysanthemum indicum and the root of purple-flowered peucedanum of above-mentioned parts by weight are taken, adds 5-10 times of the distilled water of both gross weights, steam distillation
1.5-5 hours, by gained volatile oil and distillate by volume 1:1 collects, and then adds solubilizer, is volatilized after mixing
Thing, save backup, it is standby after dregs of a decoction filtering；
(3) take the American Ginseng of above-mentioned parts by weight to crush, add the 60%-80% of 5-10 times of American Ginseng weight ethanol, heat back
Twice, each 1.5-3 hours, filtering, the dregs of a decoction are standby for stream extraction, merge extract solution, by aperture are 100nm- by extract solution
200nm ultrafiltration membrance filter, filter pressure are controlled in 0.2-0.3MPa, and temperature control collects filtrate at 25-60 DEG C, and decompression is dense
Retract and receive ethanol, it is standby to obtain American Ginseng concentrate；
(4) Chinese ephedra and fritillaria of above-mentioned parts by weight are taken, adds 5-10 times of the 70%-85% of both gross weights ethanol, heating
Twice, each 1-2 hours, filtering, the dregs of a decoction are standby for refluxing extraction, merge extract solution, by aperture are 100nm- by extract solution
200nm ultrafiltration membrance filter, filter pressure are controlled in 0.2-0.3MPa, and temperature control collects filtrate at 25-60 DEG C, and decompression is dense
Retract and receive ethanol, obtain Chinese ephedra and fritillaria concentrate is standby；
(5) beggar-ticks of above-mentioned parts by weight, the Radix Astragali, Radix Isatidis, radix glycyrrhizae, mushroom are taken, is mixed with the dregs of a decoction of step (2), (3) and (4)
Close, add the water of 5-10 times of medicinal material gross weight, decoct twice, each 1.5-3 hours, collecting decoction, decocting liquid is passed through into retention point
Son amount is 10000-200000 ultrafiltration membrance filter, and filter pressure control is in 0.2-0.3MPa, 10-38 DEG C of filtration temperature, collection
Filtrate, be concentrated under reduced pressure recovery ethanol, and it is standby to obtain mixed concentrated liquid；
(6) concentrate for obtaining the obtained volatile matter of step (2) and step (3)~(5) mixes, and adds honey, stirs evenly, obtain
To mixed liquor, mixed liquor pH value is adjusted to 4.0-6.5 with 1%-10% NaoH solution, mixed liquor is set by tubular ultra-filtration membrane
Standby filtering, molecular cut off 5000-200000, filter pressure 0.1-0.4MPa, 0-40 DEG C of filtration temperature, membrane flux are
100-200L/m3H, filtrate add water to ormal weight, sterilizing, produce.
2. treatment cold in children and the preparation method of repeated cold oral liquid as claimed in claim 1, it is characterised in that described
The step of (2) in solubilizer be polyoxyethylene sorbitan monoleate.
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| CN104997821A (en) * | 2015-07-07 | 2015-10-28 | 扬子江药业集团北京海燕药业有限公司 | Use of Radix Peucedani extract in immune function improvement |
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| CN100344313C (en) * | 2005-07-14 | 2007-10-24 | 陕西容厦药业股份有限公司 | Chinese patent drug for treating infantile cold and repeated cold, and its prepn. method |
| CN102600378B (en) * | 2011-01-19 | 2014-01-22 | 邯郸摩罗丹药业股份有限公司 | Method for preparing medicament composition by adopting ultrafiltration process |
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Effective date of registration: 20221221 Address after: No.6 Dongbo Road, East District, Guangzhou Economic and Technological Development Zone, Guangdong 510000 Patentee after: GUANGZHOU YIPINHONG PHARMACEUTICAL Co.,Ltd. Patentee after: GUANGDONG ZERUI PHARMACEUTICAL Co.,Ltd. Patentee after: Guangzhou Lianrui Pharmaceutical Co.,Ltd. Patentee after: Guangzhou Runlin Pharmaceutical Technology Co.,Ltd. Patentee after: Euphorbia Biological Medicine Co.,Ltd. Address before: Building 1, No. 6, Dongbo Road, Guangzhou Economic and Technological Development Zone, Guangdong 510760 Patentee before: GUANGZHOU YIPINHONG PHARMACEUTICAL Co.,Ltd. |