CN106924529A - A kind of Chinese medicine composition for treating cough, containing its preparation and preparation method and application - Google Patents
A kind of Chinese medicine composition for treating cough, containing its preparation and preparation method and application Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/342—Adenophora
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/534—Mentha (mint)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The present invention relates to a kind of Chinese medicine composition for treating cough, containing its preparation and preparation method and application.The Chinese medicine composition of the treatment cough contains the Chinese medicine material of following weight portion：15 25 parts of loguat leaf, 15 25 parts of the tuber of dwarf lilyturf, 12 19 parts of adenophora tetraphylla, 12 19 parts of mulberry leaf, 12 19 parts of almond, 7 13 parts of peppermint, 13 17 parts of the wind-weed, 7 13 parts of cicada slough, 13 17 parts of stiff silkworm, 13 17 parts of perilla leaf, 26 parts of fritillaria thunbergii, 5 15 parts of Radix Glycyrrhizae.Chinese medicine composition nourishing yin to moisten dryness of the present invention, dispelling wind and heat from the body, wind-dispelling is got rid of evils, and pulmonary type cough effect is significant is hindered for treatment wind-dryness.Be particularly well-suited to exogenous cough develop into wind-dryness hinder pulmonary type cough need to carry out the patient of nourishing yin to moisten dryness.
Description
Technical field
The invention belongs to technical field of pharmaceuticals, and in particular to a kind of Chinese medicine composition for treating cough, containing its preparation and its
Preparation method and application.
Background technology
Cough as lung qi is unclear, lose respectful in declaring, superinverse is uttered a word and causes cough for its disease feature.Cough, expectoration are these
The cardinal symptom of disease.Due to the cause of disease and the difference of reactivity of organism, then there is corresponding symptom and feature.What diseases caused by external factors caused coughs
Cough, expectoration mostly with heating, headache, aversion to cold etc., onset is more anxious, and the course of disease is shorter；Internal injury is cough caused, typically without diseases caused by external factors disease
Shape, onset is slow, and the course of disease is long, is often accompanied by the disease of visceral dysfunction.Its various disease is such as：Chill violates lung, and early stage pharynx is itched and coughed
And cough low voice speaking, out of breath, the thin show bubble of expectoration, or stuffy nose with watery discharge.The thin Huang of tongue, floating pulse：If from thermalization, phlegm and nasal mucus
By Bai Zhuanhuang.Wind-heat affecting lung, common cough phlegm is yellow and thick, rough, or pharyngalgia, thirsty, or the yellow tears of stream, the thin Huang of tongue, superficial and rapid pulse.It is dry
Heresy hinders lung, dry cough without phlegm or few phlegm, and nasopharynx is dried, the red dry few Tianjin of tongue, arteries and veins number.Phlegm dampness in lungs, coughs low voice speaking turbid, and gas uncomfortable in chest is suppressed, phlegm
Polychrome is sticky in vain, and white and greasy fur, arteries and veins moistens cunning.The strongly fragrant lung of phlegm heat, expectoration Huang is thick, shortness of breath uncomfortable in chest, yellowish fur, slippery and rapid pulse.Irascibility is violated
Lung, circulation of vital energy in the wrong direction cough, coughs and draws hypochondriac pain, the few Tianjin of yellow tongue fur, wiry and frequent pulse.Lung yin loss, dry cough without phlegm, or see hemoptysis, the red few tongue of tongue, arteries and veins is thin
Number.
Exogenous cough belongs to the domination of pathogen, is that exopathogen violates lung, caused by sluggishness of lung-QI is not smooth, if can not make to be reached outside exopathogen in time, and can
Further there is situations such as developing conversion, performance chillization heat, wind-heat dryness-transformation, or lung heat steaming liquid into phlegm.
The content of the invention
The present invention is intended to provide a kind of Chinese medicine composition for treating cough, containing its preparation and preparation method and application.This
Invention Chinese medicine composition nourishing yin to moisten dryness, dispelling wind and heat from the body, wind-dispelling is got rid of evils, and pulmonary type cough effect is significant is hindered for treatment wind-dryness.
Technical solution of the present invention is as follows：
A kind of Chinese medicine composition for treating cough, it contains following Chinese medicine material：Loguat leaf, the tuber of dwarf lilyturf, adenophora tetraphylla, mulberry leaf,
Almond, peppermint, the wind-weed, cicada slough, stiff silkworm, perilla leaf, fritillaria thunbergii, Radix Glycyrrhizae.
Preferably, the Chinese medicine composition of above-mentioned treatment cough, its Chinese medicine material for containing following weight portion：Loguat leaf 15-
25 parts, tuber of dwarf lilyturf 15-25 parts, adenophora tetraphylla 12-19 parts, mulberry leaf 12-19 parts, almond 12-19 parts, peppermint 7-13 parts, wind-weed 13-17
Part, cicada slough 7-13 parts, stiff silkworm 13-17 parts, perilla leaf 13-17 parts, fritillaria thunbergii 2-6 parts, Radix Glycyrrhizae 5-15 parts.
It is further preferred that the Chinese medicine composition of above-mentioned treatment cough, its Chinese medicine material for containing following weight portion：Loquat
Leaf 18-22 parts, tuber of dwarf lilyturf 18-22 parts, adenophora tetraphylla 13-17 parts, mulberry leaf 13-17 parts, almond 13-17 parts, peppermint 8-12 parts, the wind-weed
14-16 parts, cicada slough 8-12 parts, stiff silkworm 14-16 parts, perilla leaf 14-16 parts, fritillaria thunbergii 3-5 parts, Radix Glycyrrhizae 8-12 parts.
It is preferred that the Chinese medicine composition of above-mentioned treatment cough, its Chinese medicine material for containing following weight portion：Loguat leaf 20
Part, 20 parts of the tuber of dwarf lilyturf, 15 parts of adenophora tetraphylla, 15 parts of mulberry leaf, 15 parts of almond, 10 parts of peppermint, 15 parts of the wind-weed, 10 parts of cicada slough, 15 parts of stiff silkworm,
15 parts of perilla leaf, 4 parts of fritillaria thunbergii, 10 parts of Radix Glycyrrhizae.
More specifically, to be made in terms of 1 dose (i.e. daily dose), the Chinese medicine composition contains following component：Loguat leaf 15-
25g, tuber of dwarf lilyturf 15-25g, adenophora tetraphylla 12-19g, mulberry leaf 12-19g, almond 12-19g, peppermint 7-13g, wind-weed 13-17g, cicada slough 7-
13g, stiff silkworm 13-17g, perilla leaf 13-17g, fritillaria thunbergii 2-6g, Radix Glycyrrhizae 5-15g.Preferably, being made 1 dose (i.e. daily dose)
Meter, the Chinese medicine composition contains following component：Loguat leaf 18-22g, tuber of dwarf lilyturf 18-22g, adenophora tetraphylla 13-17g, mulberry leaf 13-
17g, almond 13-17g, peppermint 8-12g, wind-weed 14-16g, cicada slough 8-12g, stiff silkworm 14-16g, perilla leaf 14-16g, fritillaria thunbergii 3-
5g, Radix Glycyrrhizae 8-12g.It is preferred that to be made in terms of 1 dose (i.e. daily dose), the Chinese medicine composition contains following component：Loguat leaf
20g, tuber of dwarf lilyturf 20g, adenophora tetraphylla 15g, mulberry leaf 15g, almond 15g, peppermint 10g, wind-weed 15g, cicada slough 10g, stiff silkworm 15g, perilla leaf
15g, fritillaria thunbergii 4g, Radix Glycyrrhizae 10g.
The Chinese medicine composition of the present invention above-mentioned treatment cough can be made up of this area conventional method, such as by each raw material by matching somebody with somebody
Than mixing, or water extract will be made after the mixing of each Chinese medicine material.
Further to improve therapeutic effect, the present invention also provides a kind of preparation method of above-mentioned Chinese medicine composition, including：Press
Each Chinese medicine material is weighed according to proportioning, is decocted 1-3 times after the water immersion of 8-15 times of dosing material weight, each 0.5-2h merges and decocts
Liquid, filtration, obtains final product water extract；Or be further concentrated under reduced pressure, it is made medicinal extract；Or further dry, it is made medicinal powder.It is preferred that
Ground, the preparation method of above-mentioned Chinese medicine composition includes：Each Chinese medicine material, the 10 times of water immersions of dosing material weight are weighed according to proportioning
0.5-1h, boils 30 minutes, and filtering, filtrate is standby；Filter residue dosing material 8 times of water of weight boil 30 minutes, refilter, and filtrate is standby
With；8 times of water of dosing material weight boil 40 minutes filter residue again, refilter, and filtrate is standby；Three filtrates are merged, water extract is obtained final product.
Preferably to improve therapeutic effect, the present invention also provides the preparation method of another above-mentioned Chinese medicine composition, including：
Each Chinese medicine material is weighed according to proportioning, add medicinal material 5-15 times of 75% ethanol measured of weight, heating and refluxing extraction 1-3 times, every time
1-2h, extract solution is merged, and ethanol is recovered under reduced pressure, and is concentrated into liquor strength for 0.5g crude drugs/ml, suction filtration, by gained filtrate
Adsorption resin column is flowed through, then with the deionized water or distillation water elution of 5-15 times of resin column volume, then with 5-10 times of resin column
95% ethanol elution of volume, collects ethanol eluate, removes ethanol, obtains final product alcohol extract；Or be further concentrated under reduced pressure, it is made
Medicinal extract；Or further dry, it is made medicinal powder.
Preferably, the preparation method of above-mentioned Chinese medicine composition, including：Each Chinese medicine material is weighed according to proportioning, medicinal material is added
10 times of 75% ethanol of amount of weight, heating and refluxing extraction 3 times, each 2h merges extract solution, ethanol is recovered under reduced pressure, and concentrate
It is 0.5g crude drugs/ml to liquor strength, after suction filtration, 1.08 when the relative density of filtrate is 20 DEG C；Gained filtrate is flowed through into absorption
Resin column, then with the deionized water or distillation water elution of 10 times of resin column volumes, then with 5 times of 95% ethanol of resin column volume
Wash-out, collects ethanol eluate, removes ethanol, obtains final product alcohol extract；Or be further concentrated under reduced pressure, it is made medicinal extract；Or enter one again
Step drying, is made medicinal powder.
The present invention also provides the preparation of the Chinese medicine composition containing above-mentioned treatment cough, and the preparation is by above-mentioned Chinese traditional medicine composition
Thing is separately made, or is made up with pharmaceutically acceptable carrier or diluent of above-mentioned Chinese medicine composition.
The preparation can be tablet, capsule, pill, powder, granule, oral liquid or injection etc., the injection
Can be parenteral solution, injection sterile powder, injection freeze-dried powder and concentrated solution for injection.
The pharmaceutically acceptable carrier or diluent refer to the conventional pharmaceutical carrier of pharmaceutical field, selected from filler,
One or more in adhesive, disintegrant, lubricant, surfactant or flavouring.
Wherein described filler is selected from starch, sucrose, lactose, mannitol, sorbierite, xylitol, microcrystalline cellulose or Portugal
Grape sugar etc.；
Described adhesive is selected from cellulose derivative, alginates, gelatin or polyvinylpyrrolidone etc.；
The disintegrant is selected from microcrystalline cellulose, sodium carboxymethyl starch, polyvinylpyrrolidone, low substituted hydroxy-propyl fiber
Element or Ac-Di-Sol；
The lubricant is selected from stearic acid, polyethylene glycol, calcium carbonate, sodium acid carbonate, silica, talcum powder or stearic acid
Magnesium；
The surfactant is selected from neopelex, stearic acid, Pluronic F68, fat
Sorb is smooth or polysorbate (tween) etc. for fat acid；
The flavouring is selected from Aspartame, Sucralose or saccharin sodium.
The present invention also provides the application of above-mentioned Chinese medicine composition or above-mentioned preparation in the medicine for preparing treatment cough.
Beneficial effect：
The Chinese medicine composition that the present invention is provided is a kind of new treatment cough medicine, is treated both principal and secondary aspect of disease, determined curative effect, cost
It is low, expand medication crowd, mitigate patient's pain, for patient provides a kind of selection for treating medicine.
Chinese medicine composition toxic and side effect of the present invention is low, and plays a part of Synergistic, is particularly well-suited to exogenous cough's hair
Open up wind-dryness hinder pulmonary type cough need to carry out the patient of nourishing yin to moisten dryness.
Nourishing yin to moisten dryness of the present invention, dispelling wind and heat from the body, wind-dispelling is got rid of evils, and medicine source is extensively, harmless, and pulmonary type is hindered in treatment wind-dryness
Cough effect is significant, effective percentage, up to 82.2%, is well 93.5%.
Specific embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.It is unreceipted specific in embodiment
Technology or condition person, according to technology or condition described by document in the art, or are carried out according to product description.It is used
Reagent or the unreceipted production firm person of instrument, are the conventional products that can be commercially available by regular distributor.
A kind of Chinese medicine composition for treating cough of embodiment 1
Raw material (1 dose)：Loguat leaf 20g, tuber of dwarf lilyturf 20g, adenophora tetraphylla 15g, mulberry leaf 15g, almond 15g, peppermint 10g, the wind-weed
15g, cicada slough 10g, stiff silkworm 15g, perilla leaf 15g, fritillaria thunbergii 4g, Radix Glycyrrhizae 10g.
Preparation method：Each bulk drug will mix above, plus 1500ml water soaks 30 minutes to 1 hour, heating boils 30 points
Clock, filtering, filtrate is standby；Filter residue adds water 1000ml, heats for second, boils 30 minutes, refilters, and filtrate is standby；Filter residue is again
Added water 1000ml, and third time heating is boiled 40 minutes, is filtered；Three filtrates are merged, water extract is obtained.
Instructions of taking：The water extract is divided into two parts, a point morning and evening respectively once takes in one day；Seven doses are a course for the treatment of.
A kind of Chinese medicine composition for treating cough of embodiment 2
Raw material：Loguat leaf 20g, tuber of dwarf lilyturf 20g, adenophora tetraphylla 15g, mulberry leaf 15g, almond 15g, peppermint 10g, wind-weed 15g, cicada slough
10g, stiff silkworm 15g, perilla leaf 15g, fritillaria thunbergii 4g, Radix Glycyrrhizae 10g.
Preparation method：Each bulk drug will mix above, 10 times of ethanol of amount of dosing material gross weight, heating and refluxing extraction 3 times,
2 hours every time, No. 3 extract solutions are merged, ethanol is recovered under reduced pressure, and be concentrated into liquor strength for 0.5g crude drugs/ml, after suction filtration,
1.08 when the relative density of filtrate is 20 DEG C；Gained filtrate is flowed through into the adsorption resin column that volume is 10L, afterwards with 10 times of resins
The deionized water or distillation water elution of column volume, then with 5 times of 95% ethanol elutions of resin column volume, ethanol eluate is collected,
Removal ethanol, obtains final product alcohol extract；Further it is concentrated under reduced pressure, is made medicinal extract；Further dry, be made medicinal powder；According to a conventional method
It is made capsule.
A kind of Chinese medicine composition for treating cough of embodiment 3
Raw material：Loguat leaf 20g, tuber of dwarf lilyturf 20g, adenophora tetraphylla 15g, mulberry leaf 15g, almond 15g, peppermint 10g, wind-weed 15g, cicada slough
10g, stiff silkworm 15g, perilla leaf 15g, fritillaria thunbergii 4g, Radix Glycyrrhizae 10g.
Preparation method：Each Chinese medicine material is weighed according to proportioning, 10 times of water immersion 0.5-1h of dosing material weight boil 30 points
Clock, filtering, filtrate is standby；Filter residue dosing material 8 times of water of weight boil 30 minutes, refilter, and filtrate is standby；Filter residue dosing material weight again
8 times of water of amount boil 40 minutes, refilter, and filtrate is standby；Three filtrates are merged, water extract is obtained final product；Further it is concentrated under reduced pressure, makes
Into medicinal extract；Further dry, be made medicinal powder；Capsule is made according to a conventional method.
A kind of Chinese medicine composition for treating cough of embodiment 4
Raw material：Loguat leaf 22g, tuber of dwarf lilyturf 22g, adenophora tetraphylla 17g, mulberry leaf 17g, almond 17g, peppermint 12g, wind-weed 16g, cicada slough
12g, stiff silkworm 16g, perilla leaf 16g, fritillaria thunbergii 5g, Radix Glycyrrhizae 12g.
Capsule is made according to the same manner as in Example 3.
A kind of Chinese medicine composition for treating cough of embodiment 5
Raw material：Loguat leaf 18g, tuber of dwarf lilyturf 18g, adenophora tetraphylla 13g, mulberry leaf 13g, almond 13g, peppermint 8g, wind-weed 14g, cicada slough
8g, stiff silkworm 14g, perilla leaf 14g, fritillaria thunbergii 3g, Radix Glycyrrhizae 8g.
Capsule is made according to the same manner as in Example 3.
A kind of Chinese medicine composition for treating cough of embodiment 6
Raw material：Loguat leaf 22g, tuber of dwarf lilyturf 22g, adenophora tetraphylla 15g, mulberry leaf 15g, almond 15g, peppermint 12g, wind-weed 15g, cicada slough
12g, stiff silkworm 15g, perilla leaf 15g, fritillaria thunbergii 4g, Radix Glycyrrhizae 10g.
Capsule is made according to the same manner as in Example 3.
A kind of Chinese medicine composition for treating cough of embodiment 7
With differing only in for embodiment 3：Be made after medicinal powder be respectively prepared according to a conventional method again tablet, powder, granule,
Pill, oral liquid, injection.
A kind of Chinese medicine composition for treating cough of embodiment 8
With differing only in for embodiment 4：Be made after medicinal powder be respectively prepared according to a conventional method again tablet, powder, granule,
Pill, oral liquid, injection.
A kind of Chinese medicine composition for treating cough of embodiment 9
With differing only in for embodiment 5：Be made after medicinal powder be respectively prepared according to a conventional method again tablet, powder, granule,
Pill, oral liquid, injection.
A kind of Chinese medicine composition for treating cough of embodiment 10
With differing only in for embodiment 6：Be made after medicinal powder be respectively prepared according to a conventional method again tablet, powder, granule,
Pill, oral liquid, injection.
A kind of Chinese medicine composition for treating cough of embodiment 11
Raw material：Loguat leaf 20g, tuber of dwarf lilyturf 20g, adenophora tetraphylla 15g, mulberry leaf 15g, almond 18g, peppermint 10g, wind-weed 15g, cicada slough
10g, stiff silkworm 15g, perilla leaf 15g, fritillaria thunbergii 4g, Radix Glycyrrhizae 10g.
Capsule is made according to the same manner as in Example 2.
A kind of Chinese medicine composition for treating cough of embodiment 12
Raw material：Loguat leaf 22g, tuber of dwarf lilyturf 20g, adenophora tetraphylla 15g, mulberry leaf 15g, almond 18g, peppermint 10g, wind-weed 15g, cicada slough
10g, stiff silkworm 15g, perilla leaf 15g, fritillaria thunbergii 4g, Radix Glycyrrhizae 10g.
Capsule is made according to the same manner as in Example 2.
A kind of Chinese medicine composition for treating cough of embodiment 13
Raw material：Loguat leaf 22g, tuber of dwarf lilyturf 22g, adenophora tetraphylla 15g, mulberry leaf 15g, almond 18g, peppermint 10g, wind-weed 15g, cicada slough
10g, stiff silkworm 15g, perilla leaf 15g, fritillaria thunbergii 4g, Radix Glycyrrhizae 10g.
Capsule is made according to the same manner as in Example 2.
A kind of Chinese medicine composition for treating cough of embodiment 14
Raw material：Loguat leaf 22g, tuber of dwarf lilyturf 22g, adenophora tetraphylla 15g, mulberry leaf 15g, almond 18g, peppermint 10g, wind-weed 15g, cicada slough
12g, stiff silkworm 15g, perilla leaf 15g, fritillaria thunbergii 4g, Radix Glycyrrhizae 10g.
Capsule is made according to the same manner as in Example 2.
A kind of Chinese medicine composition for treating cough of embodiment 15
With differing only in for embodiment 2：Be made after medicinal powder be respectively prepared according to a conventional method again tablet, powder, granule,
Pill, oral liquid, injection.
A kind of Chinese medicine composition for treating cough of embodiment 16
With differing only in for embodiment 11：Tablet, powder, particle are respectively prepared according to a conventional method again after being made medicinal powder
Agent, pill, oral liquid, injection.
A kind of Chinese medicine composition for treating cough of embodiment 17
With differing only in for embodiment 12：Tablet, powder, particle are respectively prepared according to a conventional method again after being made medicinal powder
Agent, pill, oral liquid, injection.
A kind of Chinese medicine composition for treating cough of embodiment 18
With differing only in for embodiment 13：Tablet, powder, particle are respectively prepared according to a conventional method again after being made medicinal powder
Agent, pill, oral liquid, injection.
A kind of Chinese medicine composition for treating cough of embodiment 19
With differing only in for embodiment 14：Tablet, powder, particle are respectively prepared according to a conventional method again after being made medicinal powder
Agent, pill, oral liquid, injection.
Comparative example 1
A kind of Chinese medicine composition, the raw material that differs only in embodiment 1 does not include loguat leaf.
Comparative example 2
A kind of Chinese medicine composition, the raw material that differs only in embodiment 1 does not include the tuber of dwarf lilyturf.
Comparative example 3
A kind of Chinese medicine composition, the raw material that differs only in embodiment 2 does not include peppermint.
Comparative example 4
A kind of Chinese medicine composition, the raw material that differs only in embodiment 2 does not include cicada slough.
Model case
Case 1
Liu, 27 years old, man, when autumn sees and treat patients, patient's dry cough without phlegm or has viscous phlegm on a small quantity, is difficult to bring up, and is diagnosed as wind-dryness
Hinder pulmonary type cough.
The Chinese medicine composition of embodiment 1 (water extract) is taken, the water extract is divided into two parts, a point morning and evening respectively once takes in one day
With.After taking 7 days, symptom recovery from illness is visited, without recurrence after two months.
Case 2
Mrs Lu, 32 years old, when spring sees and treat patients, dry cough was repeatedly done and is choked, and larynx is itched, pharyngodynia with dryness, lip xeromycteria, without phlegm, dry
With nasal obstruction, headache body heat is diagnosed as wind-dryness and hinders pulmonary type cough.
The Chinese medicine composition of embodiment 1 (water extract) is taken, the water extract is divided into two parts, a point morning and evening respectively once takes in one day
With.After taking 12 doses, symptom mitigation, continuous to take 6 doses, recovery from illness is visited, without recurrence after half a year.
Case 3
Zhang, man, 36 years old, symptom of seeing and treating patients was：Dry cough, lip xeromycteria, nasal obstruction, headache, red tongue body, tongue is thin white or thin Huang,
Dry and few Tianjin, superficial and rapid pulse is diagnosed as wind-dryness and hinders pulmonary type cough.
The Chinese medicine composition of embodiment 1 (water extract) is taken, the water extract is divided into two parts, a point morning and evening respectively once takes in one day
With.After taking 8 doses, symptom mitigation is continuous to take 6 doses, recovery from illness, after half a year after visit, without recurrence.
Case 4
Mr. Huang, 32 years old, dry cough, phlegm was few and glutinous, sputum with blood streaks, the thin Huang of tongue, and nasal obstruction is diagnosed as wind-dryness with headache
Hinder pulmonary type cough.
The Chinese medicine composition of embodiment 1 (water extract) is taken, the water extract is divided into two parts, a point morning and evening respectively once takes in one day
With.After taking 10 doses, symptom mitigation is continuous to take 6 doses, recovery from illness, after half a year after visit, without recurrence.
Although above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (10)
1. a kind of Chinese medicine composition for treating cough, it is characterised in that the Chinese medicine material containing following weight portion：Loguat leaf 15-
25 parts, tuber of dwarf lilyturf 15-25 parts, adenophora tetraphylla 12-19 parts, mulberry leaf 12-19 parts, almond 12-19 parts, peppermint 7-13 parts, wind-weed 13-17
Part, cicada slough 7-13 parts, stiff silkworm 13-17 parts, perilla leaf 13-17 parts, fritillaria thunbergii 2-6 parts, Radix Glycyrrhizae 5-15 parts.
2. Chinese medicine composition according to claim 1, it is characterised in that the Chinese medicine material containing following weight portion：Loquat
Leaf 18-22 parts, tuber of dwarf lilyturf 18-22 parts, adenophora tetraphylla 13-17 parts, mulberry leaf 13-17 parts, almond 13-17 parts, peppermint 8-12 parts, the wind-weed
14-16 parts, cicada slough 8-12 parts, stiff silkworm 14-16 parts, perilla leaf 14-16 parts, fritillaria thunbergii 3-5 parts, Radix Glycyrrhizae 8-12 parts；
Preferably, the Chinese medicine composition of the treatment cough, its Chinese medicine material for containing following weight portion：20 parts of loguat leaf, wheat
20 parts of winter, 15 parts of adenophora tetraphylla, 15 parts of mulberry leaf, 15 parts of almond, 10 parts of peppermint, 15 parts of the wind-weed, 10 parts of cicada slough, 15 parts of stiff silkworm, perilla leaf
15 parts, 4 parts of fritillaria thunbergii, 10 parts of Radix Glycyrrhizae.
3. the preparation method of Chinese medicine composition described in claim 1 or 2, it is characterised in that including：Each Chinese medicine is weighed according to proportioning
Raw material, decocts 1-3 times, each 0.5-2h after the water immersion of 8-15 times of dosing material weight, merges decoction liquor, and filtration obtains final product water extraction
Thing；Or be further concentrated under reduced pressure, it is made medicinal extract；Or further dry, it is made medicinal powder.
4. preparation method according to claim 3, it is characterised in that including：Each Chinese medicine material, dosing are weighed according to proportioning
10 times of water immersion 0.5-1h of material weight, boil 30 minutes, filter, and filtrate is standby；Filter residue dosing material 8 times of water of weight boil 30 points
Clock, refilters, and filtrate is standby；8 times of water of dosing material weight boil 40 minutes filter residue again, refilter, and filtrate is standby；By three filtrates
Merge, obtain final product water extract.
5. the preparation method of Chinese medicine composition described in claim 1 or 2, it is characterised in that including：Each Chinese medicine is weighed according to proportioning
Raw material, adds medicinal material 5-15 times of 75% ethanol measured of weight, and heating and refluxing extraction 1-3 times, each 1-2h merges extract solution,
Ethanol is recovered under reduced pressure, and is concentrated into liquor strength for 0.5g crude drugs/ml, gained filtrate is flowed through adsorption resin column, then by suction filtration
With the deionized water or distillation water elution of 5-15 times of resin column volume, then with 5-10 times of 95% ethanol elution of resin column volume,
Ethanol eluate is collected, ethanol is removed, alcohol extract is obtained final product；Or be further concentrated under reduced pressure, it is made medicinal extract；Or further do
It is dry, it is made medicinal powder.
6. preparation method according to claim 5, it is characterised in that including：Each Chinese medicine material is weighed according to proportioning, is added
10 times of 75% ethanol of amount of medicinal material weight, heating and refluxing extraction 3 times, each 2h merges extract solution, and ethanol is recovered under reduced pressure, and
Liquor strength is concentrated into for 0.5g crude drugs/ml, after suction filtration, 1.08 when the relative density of filtrate is 20 DEG C；Gained filtrate is flowed through
Adsorption resin column, then with the deionized water or distillation water elution of 10 times of resin column volumes, then with 5 times the 95% of resin column volume
Ethanol elution, collects ethanol eluate, removes ethanol, obtains final product alcohol extract.
7. the Chinese medicine composition that prepared by any one of claim 3-6 methods described.
8. the preparation of the Chinese medicine composition described in claim 1-2,7 any one is contained, it is characterised in that the preparation is by described
Chinese medicine composition is separately made, or is made up with pharmaceutically acceptable carrier or diluent of the Chinese medicine composition.
9. preparation according to claim 8, it is characterised in that the preparation is tablet, capsule, pill, powder, particle
Agent, oral liquid or injection.
10. the Chinese medicine composition described in claim 1-2,7 any one, or preparation described in claim 8 or 9 is treated preparing
Application in the medicine of cough.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113197968A (en) * | 2021-05-08 | 2021-08-03 | 吴斌 | Traditional Chinese medicine formula for treating cough after infection based on radix adenophorae and radix ophiopogonis decoction flavor |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102772652A (en) * | 2012-07-12 | 2012-11-14 | 严中明 | Traditional Chinese medicine composition for treating cough and preparation method thereof |
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2017
- 2017-04-11 CN CN201710233703.2A patent/CN106924529A/en not_active Withdrawn
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102772652A (en) * | 2012-07-12 | 2012-11-14 | 严中明 | Traditional Chinese medicine composition for treating cough and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113197968A (en) * | 2021-05-08 | 2021-08-03 | 吴斌 | Traditional Chinese medicine formula for treating cough after infection based on radix adenophorae and radix ophiopogonis decoction flavor |
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