CN104547351B - Treat the Chinese herbal medicament oral liquid of infectious coryza of chicken - Google Patents
Treat the Chinese herbal medicament oral liquid of infectious coryza of chicken Download PDFInfo
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Abstract
A kind of Chinese herbal medicament oral liquid for treating infectious coryza of chicken, it is made of the bulk pharmaceutical chemicals of following weight parts：4 parts 6 parts of climbing groundsel, 3 parts 5 parts of the achene of Siberian cocklebur, 3 parts 5 parts of fructus viticis, 3 parts 5 parts of cassia seed, 2 parts 4 parts of evodia lepta, 2 parts 4 parts of grass-leaved sweetflag, 2 parts 4 parts of Caulis Spatholobi, 1 part 2 parts of wrinkled giant hyssop, 1 part 2 parts of peppermint, 1 part 2 parts of Radix Glycyrrhizae.This Chinese herbal medicament oral liquid is short treating period, cure rate height, safe without toxic side effect, convenient to take for treating infectious coryza of chicken.
Description
Technical field
The present invention relates to the Chinese herbal and crude drugs preparations of poultry, and in particular to a kind of Chinese herbal medicine for treating infectious coryza of chicken is oral
Liquid.
Background technology
Infectious coryza of chicken is the acute respiratory disease of the chicken caused by haemophilus paragallinarum.Cardinal symptom is nasal cavity
With the inflammation of sinus, performance runny nose, facial edema and conjunctivitis.This disease is distributed in the whole world, due to the laying rate of chicken of laying eggs of infection
10%~40% is reduced, Young cock weightening is stagnated and eliminate chicken number increases, and often results in serious financial consequences.Currently, treatment chicken passes
Metachromia rhinitis using it is more be Antibiotics Western medicine, although having certain curative effect, the disadvantage is that drug resistance and side effect compared with
Seriously, and in chicken and egg chemicals residue is had, potential threat is brought to human health；Chinese herbal medicine has day
So, have no toxic side effect, without chemicals residue, be not likely to produce the features such as drug resistance, for poultry husbandry diseases prevention, cure the disease, have
It is widely applied foreground.But the presently commercially available Chinese herbal and crude drugs preparations for treating infectious coryza of chicken, using effect is poor, cure rate
Low, the course for the treatment of is long and of high cost.
Invention content
It is an object of the invention in view of the above-mentioned problems, provide a kind of easy to use, at low cost, can effectively treat chicken biography
The Chinese herbal medicament oral liquid of metachromia rhinitis.
The technical scheme is that：A kind of Chinese herbal medicament oral liquid for treating infectious coryza of chicken, it is by following weight
Medicament made of the bulk pharmaceutical chemicals of part：4 parts -6 parts of climbing groundsel, 3 parts -5 parts of the achene of Siberian cocklebur, 3 parts -5 parts of fructus viticis, 3 parts -5 parts of cassia seed,
2 parts -4 parts of evodia lepta, 2 parts -4 parts of grass-leaved sweetflag, 2 parts -4 parts of Caulis Spatholobi, 1 part -2 parts of wrinkled giant hyssop, 1 part -2 parts of peppermint, 1 part -2 of Radix Glycyrrhizae
Part.
The preferred raw material medicine parts by weight of the Chinese herbal medicament oral liquid of cost treatment infectious coryza of chicken processed are：4 parts of climbing groundsel, it is grey
3 parts of the ears or side handles of a utensil, 3 parts of fructus viticis, 3 parts of cassia seed, 3 parts of evodia lepta, 3 parts of grass-leaved sweetflag, 3 parts of Caulis Spatholobi, 1 part of wrinkled giant hyssop, 1 part of peppermint are sweet
1 part of grass.
The preparation method of the Chinese herbal medicament oral liquid of this treatment infectious coryza of chicken is：Climbing groundsel, Siberian cocklebur are weighed by weight
Son, fructus viticis, cassia seed, evodia lepta, grass-leaved sweetflag, Caulis Spatholobi, wrinkled giant hyssop, peppermint, Radix Glycyrrhizae herbal decoction piece, and be respectively crushed into
Herbal medicine coarse powder；Wrinkled giant hyssop, peppermint Chinese herbal medicine coarse powder are taken, the volatile oil distilled out is collected with steam distillation；The another climbing groundsel, grey of taking
The ears or side handles of a utensil, fructus viticis, cassia seed, evodia lepta, grass-leaved sweetflag, Caulis Spatholobi, eight taste Chinese herbal medicine coarse powder of Radix Glycyrrhizae, after soaking and after distillation
Wrinkled giant hyssop, the peppermint dregs of a decoction are cooked by slow fire together；Filtering, obtains first-time filtrate；The dregs of a decoction after first-time filtrate are taken to add water decoction two
It is secondary, respectively obtain secondary filtrate and three times filtrate；Merge filtrate three times, is heated as concentrate；Volatile oil and concentrate are closed
And by preservative and water is quantitatively adding, stir evenly, it filters, filling, sterilizing obtains this Chinese herbal medicament oral liquid.
Each component pharmacological effect is in this Chinese herbal medicament oral liquid prescription：
Climbing groundsel effect：The bright grass of climbing groundsel alias Herba Senecionis Scandentis, eye, a thousand li are bright.Bitter, cold in nature, return lung, liver, large intestine channel.Flower
Containing the sterols such as faradiol, rutin, hyperin, triterpenoid saponin, tannin, wax, volatile oil and taraxanthin, leaf is containing hardship
Taste glucoside, gallic acid, elastic rubber sample substance, dextrin, mucus, synanthrin, phytosterol, stearic acid and tripalmitin, wine
Stone acid, malic acid, inverted sugar, choline, hydrocarbon and saponin, fresh quench stem is containing volatile oil, paraffin, synanthrin, tannin.Has heat-clearing
The effect of removing toxic substances, removing nebula, antipruritic desinsection.For influenza, the infection of the upper respiratory tract, pneumonia, chordapsus, bacillary dysentery, eczema etc..
Achene of Siberian cocklebur effect：Achene of Siberian cocklebur alias lice head of the horse, the road number of people, eight naked, grey prodigals of thorn, pig ear, dish ear, grey son.Nature and flavor
It is bitter, sweet, pungent, return lung, Liver Channel.Fruit is containing xanthostrumarin, resin and fat oil, alkaloid, vitamin C and pigment etc..Have
The effect of clearing the nasal passage, wind-damp dispelling, analgesic.For anemofrigid headache, nasal congestion, wind-cold-dampness arthralgia, skin eczema etc..
Fructus viticis effect：Fructus viticis alias capital, nature and flavor are arduous, tremble with fear.Return liver, stomach, bladder warp.Containing volatile oil and micro life
Alkaloids and vitamin A, negundo chastetree fruit flavones, vitricin, palmitic acid, stearic acid, palmitoleic acid, oleic acid and linoleic acid, γ-fertility
Phenol and cupreol.Separately contain p-hydroxy Benzoic Acid, p- anisic acid and vanillic aldehyde.Has the effect of dispelling wind and heat from the body, head clearing.With
In pain, dim unknown, arthritis with fixed pain caused by dampness contraction etc. in affection of exogenous wind-heat, the more tears of red eye, swell pain, mesh eyeball.
Cassia seed effect：Cassia seed alias Cassia occidentalis, sheep be bright, goat's horn, horseshoe Cassia, go back pupil, bullshit beans, false mung bean,
Horseshoe, climbing groundsel, celery certainly, swordweed.The salty hardship of taste, it is cool in nature.Return liver, courage, kidney channel.Containing anthraquinone analog compound, main includes big
Yellow phenol, Physcion, obtusifoline, yellow obtusin, obtusin, luxuriant growth rheum emodin, Italian sandlwood anthraquinone -1-O- glucose
Glycosides, 1- demethyls aurantio-obtusin, Huang obtusin 2-O- β-D-Glucose glycosides, glucosyl group obtusifoline, glucosyl group are yellow
Obtusin etc..Has the effect of expelling wind and clearing away heat, detoxification and promoting urination.It is slow for anemopyretic cold, influenza, acute conjunctivitis, jaundice with damp-heat pathogen, urgency
Property ephritis, scrofula etc..
Evodia lepta effect：Evodia lepta alias evodia lepta merr, trident tiger, three forks are bitter, and ringdove flower, little Huang dissipates, three trouble leaves, three rifles
Deng.It is bitter in taste, it trembles with fear.Return liver, lung, stomach.Leaf, root contain alkaloid, also contain volatile oil, and main component is a- firpenes and chaff in oil
Aldehyde.Has the effect of clearing heat and detoxicating, dispelling wind and eliminating dampness.For diseases such as abscess of throat, treating rheumatic ostealgia, malaria, jaundice, eczemas.
Caulis Spatholobi effect：Caulis Spatholobi alias blood rattan, CAULIS SPATHOLOBI.Bitter in taste, sweet, warm.Return liver and kidney channel.Containing ononis spinosa
Element, ononin, prunetin, A Fuluomoxin, cajinin, licochalcone, isoliquiritigenin, tetrahydroxy chalcone, soybean are yellow
Element, medicagol, epicatechin, protocatechuic acid, b- sitosterol, daucosterol etc..Has the effect of replenishing and activating blood, dredging collateral.For blood
Empty sallow, paralysis and numbness, the diseases such as arthralgia pain due to rheumatism.
Grass-leaved sweetflag effect：Grass-leaved sweetflag also known as mountain calamus, medicine calamus, money Pu, grassleaf sweetflag leaf, water sword grass, white flag.It is warm-natured,
Acrid flavour, hardship.Return liver, the spleen channel.Containing volatile oil, inside there are α-, β-and γ-asarone, asarabacca brain, cis- methyl tert-butyl sesame oil phenol,
Elemicine, asarylaldehyde, Thymol, Pork and beans labour acid etc..There is the effect of slit phlegm of having one's ideas straightened out, vital energy regualting and blood circulation-promoting, relieve heat is dried.For
Coma due to blocking of the respiratory system, pyreticosis coma, wind-cold-dampness arthralgia, swollen ulcer drug etc..
Wrinkled giant hyssop effect：The blending of wrinkled giant hyssop alias, grey announcement, mountain fennel etc..Nature and flavor are pungent, tepor.Returns spleen, stomach, lung channel.Herb is containing virtue
It is mainly estragole, limonene, australene and nopinene, p-cymene, linalool, I- cloves alkene in fragrant volatile oil, oil
Deng, and containing protein, fat, carbohydrate, carrotene, calcium, phosphorus, iron etc..Tool is eliminated dampness with aromatics and middle preventing or arresting vomiting, delivers relieving summer-heat
The effect of.For turbi damp obstructing in middle-JIAO, the vomiting of gastral cavity ruffian, summer-heat and damp exterior syndrome, damp-warm syndrome is from the beginning of burnout of generating heat, uncomfortable in chest not relax, cold-dampness closes heat, abdomen
Pain is vomited and diarrhoea, nasosinusitis headache etc..
Peppermint effect：Peppermint alias HERBA MENTHAE, night breath perfume, southern peppermint, fish mint etc..Acrid flavour, it is cool in nature.Distributed in lung channel, Liver Channel.
Containing volatile oil, in volatile oil main composition be levorotatory menthol, also contain left-handed menthones isomenthone, pulegone, decyl acetate,
Menthyl acetate methyl benzoate, α-and nopinene, dextrorotation laurene, limonene and Cineole, alpha-terpineol etc..Contain flavones again
Class composition peppermint daidzin, Composition of Organic Acids Rosmarinic acid, caffeic acid, chloro acid composition aspartic acid, glutamic acid, serine
Deng, also dihydroxy -1,2- dihydronaphthalene dihydroxy acid be parent nucleus multiple components.With dispelling wind and heat from the body, head clearing, relieving sore-throat is saturating
The effect of rash, soothing the liver promoting the circulation of qi.For wind-dispelling heat-dissipating, detoxify, food stagnation inflatable, aphtha, warm disease is from the beginning of equal diseases.
Radix Glycyrrhizae effect：Radix Glycyrrhizae alias Herba Hedyotis cantonensis root, Radix Glycyrrhizae, unpeeled RADIX GLYCYRRHIZAE.It is mild-natured, sweet in flavor, return 12 warps.Containing glycyrrhizic acid, sweet
The ingredients such as careless glucin, 24- hydroxyls enoxolone, licoflavone, glycyrrhizin, isoliquiritigenin, licorice polysaccharide.With antiulcer, promote
Into pancreatic secretion, liver protection, lipid-loweringing, adjust the effects that phagocytic function of macrophage.Glycyrrhizic acid is natural antidote, can be used for machine
Body anti-aging, strengthen immunity, maintenance water-electrolyte metabolism balance etc.；Licorice polysaccharide has anti-adenovirus type III, herpes simplex virus I
Type activity.
This Chinese herbal medicament oral liquid prescription foundation：Infectious coryza of chicken, after respiratory tract infection haemophilus paragallinarum,
Accumulate in heat toxin, phlegm and retained fluid blocks nasal cavity, leads to Dou Fayan, has a running nose, facial swelling and sneezing.Therefore treatment on preferably with dispersing wind and cold,
Clearing the nasal passage, wind-damp dispelling, the carbuncle that disappears anti-inflammatory are the rules for the treatment of.Climbing groundsel, evodia lepta, Caulis Spatholobi have convergence and protection to make schneiderian membrance in side
With, so that secretion is reduced, local Marjoram Extract, cycle improve, can promote secretion absorb and inflammatory resolution；With the achene of Siberian cocklebur,
Fructus viticis, cassia seed, grass-leaved sweetflag, wrinkled giant hyssop, peppermint alleviate nasal sinus swelling, dehumidifying scattered silt, penetrating nose key, remove rheumatism, and antibacterial disappears
Scorching, dispersing superficial exopathogens effect；Radix Glycyrrhizae adjusts body's immunity, sweet temperature QI invigorating, invigorating spleen, current twelve channels and collaterals, coordinating the drug actions of a prescription.
In side all medicine phases and, the effect of playing antibacterial anti-inflammatory, penetrating nose key, remove rheumatism altogether, improve immunity of organisms and disease resistance.It is suitable
For the infectious coryza of chicken caused by haemophilus paragallinarum.For convenience of the application in chicken disease control, oral solution is made.
The Chinese herbal medicament oral liquid of this treatment infectious coryza of chicken is foundation on the basis of having carried out a large amount of practical applications
Traditional medicine ancient prescription is screened in conjunction with modern popular disease, aetology and immunologic theory.This Chinese herbal medicament oral liquid is used for
Infectious coryza of chicken is treated, short treating period, treatment cost are low, cure rate is high, safe and free of toxic and side effects, easy to use.
Specific implementation mode
With reference to embodiment, the invention will be further described.
Embodiment：
1, bulk pharmaceutical chemicals (herbal decoction piece) are weighed respectively：Climbing groundsel 160g, achene of Siberian cocklebur 120g, fructus viticis 120g, cassia seed
120g, evodia lepta 120g, grass-leaved sweetflag 120g, Caulis Spatholobi 120g, wrinkled giant hyssop 40g, peppermint 40g, Radix Glycyrrhizae 40g；
2, above-mentioned raw materials medicine is respectively crushed into Chinese herbal medicine coarse powder；
3, each 40g Chinese herbal medicines coarse powder of wrinkled giant hyssop, peppermint is taken, is set in distillation container, with steam distillation, heating extraction volatilization
Oil collects the volatile oil distilled out, is placed in container and stores；It is another to take climbing groundsel 160g, achene of Siberian cocklebur 120g, fructus viticis 120g, determine
Pine torch 120g, evodia lepta 120g, grass-leaved sweetflag 120g, Caulis Spatholobi 120g, eight taste Chinese herbal medicine coarse powder of Radix Glycyrrhizae 40g add water 4000mL to soak
After steeping 1h, with after above-mentioned distillation wrinkled giant hyssop, together with the peppermint dregs of a decoction, water is cooked by slow fire 30min after opening；Filtering, obtains first-time filtrate；
It takes the dregs of a decoction after first-time filtrate to add water 3000mL to decoct secondary, each 20min every time again, respectively obtains secondary filtrate and filter three times
Liquid；Merge filtrate three times, heating is concentrated into about 900mL；
4, the volatile oil that above-mentioned distillation obtains is merged with the concentrate of heating concentration, 0.05% sodium benzoate conduct is added
Preservative adds water to 1000mL, stirs evenly, filtering, filling, sterilizing, and the Chinese herbal medicine for obtaining this treatment infectious coryza of chicken is oral
Liquid.
Some test situations carried out using the Chinese herbal medicament oral liquid of this treatment infectious coryza of chicken are as follows：
Newcastle disease vaccine is immunized in 200 1 age in days hy-line brown hens respectively when 7 ages in days, 27 age in days, when 12 ages in days, 22 age in days
Immune bursa of farbricius trivalent vaccine, not immune infectious coryza of chicken vaccine, parent is for no infective rhinitis's medical history.In 90 age in days with
Machine is divided into 5 groups, every group 30, totally 150, and when 90 age in days attacks poison, and every chicken is cultivated from nasal cavity instillation haemophilus paragallinarum Hpg14
Liquid 0.2mL (2 × 109CFU/mL), the successive administration time is 7d.Experiment grouping and processing are shown in Table 1, and control effect is shown in Table 2.
The experiment of table 1 grouping and processing (unit：Only)
| Group | Processing | Daily administration number |
| Treatment group A | After attacking poison, with this Chinese herbal medicament oral liquid, 1mL/ is only secondary | 2 |
| Treatment group B1 | After the onset with this Chinese herbal medicament oral liquid, 1mL/ secondary | 2 |
| Treatment group B2 | Roxithromycin, 0.1% mixed drink are used after the onset | 2 |
| Control group C1 | Attack not medication after poison | 0 |
| Control group C2 | Malicious not medication is not attacked | 0 |
Control effect (unit of 2 Chinese herbal medicament oral liquids of table to artificial challenge's haemophilus paragallinarum：%, only)
| Group | 3d diseased chicken numbers | 4d diseased chicken numbers | 6d diseased chicken numbers | 8d diseased chicken numbers | 11d diseased chicken numbers | Cure rate | Death toll |
| Treatment group A | 0 | 2aabb | 0aabb | 0aabb | 0aabb | 100.0 | 0 |
| Treatment group B1 | 2 | 38 | 16aabd | 3aabbdd | 1aabbd | 97.5 | 0 |
| Treatment group B2 | 1 | 39 | 26 | 16a | 12a | 70 | 0 |
| Control group C1 | 2 | 38 | 32 | 25 | 21 | 47.5 | 4 |
| Control group C2 | 0 | 0aa | 0aa | 0aa | 0aa | 100 | 0 |
Note：A is indicated and C1Group significant difference (P<0.05), aa indicates difference extremely significantly (P<0.01)；B indicates A1、B1With B2
Group significant difference (P<0.05), bb indicates difference extremely significantly (P<0.01)；Dd indicates difference extremely significantly (P<0.01).
The 3d after attacking poison, the non-individual chicken morbidities of prevention administration group, has rhinorrhea, swollen face, gets rid of the symptoms such as nose.After attacking poison
4d chickens mass-sending disease there is highest, especially B1、B2Group and C1Then group almost all morbidity is in reduction trend, the
4d, by comparing incidence, treatment group A and treatment group B1、B2And C1、C2Group has pole significant difference (P<0.01), experiment is seen
The phase of examining terminates by comparing each group cure rate, each group and C1The poor heteropolar significantly (P of group<0.01), A, B1、B2Group significant difference
(P<0.05), wherein attacking malicious control group 4 chicken deaths in 4d~6d, A, B1Respectively in 5d, 7d, 9d without disease symptom
Chicken.
By to 150 90 age in days artificial challenge's Growing Chickens treatment observations, infection of this Chinese herbal medicament oral liquid to Growing Chicken
Property rhinitis have a significant therapeutic efficiency, cure rate is 97% or more, generally through 5d~7d diseased chicken rehabilitations.Dispensing whole process has no chicken group
There are any adverse reaction, selective examination to cure chicken dissection, nasal cavity, tracheae, larynx are showed no eye and see pathological change, histological examination nose
Chamber, larynx, tracheae, internal organs etc. are normal.
Claims (1)
1. a kind of Chinese herbal medicament oral liquid for treating infectious coryza of chicken, it is characterised in that it is the medicament made of following raw material medicaments
：Climbing groundsel, the achene of Siberian cocklebur, fructus viticis, cassia seed, evodia lepta, grass-leaved sweetflag, Caulis Spatholobi, wrinkled giant hyssop, peppermint, Radix Glycyrrhizae；
The preparation method of Chinese herbal medicament oral liquid of the treatment infectious coryza of chicken is：
1）Bulk pharmaceutical chemicals are weighed respectively：Climbing groundsel 160g, achene of Siberian cocklebur 120g, fructus viticis 120g, cassia seed 120g, evodia lepta 120g,
Grass-leaved sweetflag 120g, Caulis Spatholobi 120g, wrinkled giant hyssop 40g, peppermint 40g, Radix Glycyrrhizae 40g；
2）Above-mentioned raw materials medicine is respectively crushed into Chinese herbal medicine coarse powder；
3）Each 40g Chinese herbal medicines coarse powder of wrinkled giant hyssop, peppermint is taken, is set in distillation container, with steam distillation, heating extraction volatile oil,
The volatile oil distilled out is collected, is placed in container and stores；Separately take climbing groundsel 160g, achene of Siberian cocklebur 120g, fructus viticis 120g, Cassia
Sub- 120g, evodia lepta 120g, grass-leaved sweetflag 120g, Caulis Spatholobi 120g, eight taste Chinese herbal medicine coarse powder of Radix Glycyrrhizae 40g add water 4000mL to impregnate
After 1h, with after above-mentioned distillation wrinkled giant hyssop, together with the peppermint dregs of a decoction, water is cooked by slow fire 30min after opening；Filtering, obtains first-time filtrate；It takes
The dregs of a decoction after first-time filtrate add water 3000mL to decoct secondary, each 20min every time again, respectively obtain secondary filtrate and filter three times
Liquid；Merge filtrate three times, heating is concentrated into 900mL；
4）The volatile oil that above-mentioned distillation obtains is merged with the concentrate of heating concentration, 0.05% sodium benzoate is added as anti-corrosion
Agent adds water to 1000mL, stirs evenly, filtering, filling, sterilizing.
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| 中草药防治鸡传染病研究进展;张庆茹;《中兽医学杂志》;20020430(第4期);第26页 * |
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