CN104547187A - Compound fermented traditional Chinese medicine for preventing and treating chicken salmonellosis - Google Patents
Compound fermented traditional Chinese medicine for preventing and treating chicken salmonellosis Download PDFInfo
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Abstract
The invention discloses a compound fermented traditional Chinese medicine for preventing and treating chicken salmonellosis. The compound fermented traditional Chinese medicine is prepared from the following components in parts by weight: 45-60 parts of Chinese pulsatilla root, 20-40 parts of atractylodes macrocephala, 10-30 parts of coptis, 10-30 parts of phellodendron amurense, 5-15 parts of clove, 5-20 parts of agastache, 40-60 parts of dandelion, 10-30 parts of radix sophorae flavescentis, 2-15 parts of gentian, 10-30 parts of purslane, and 5-20 parts of radix paeoniae alba. The traditional Chinese medicine composition is prepared by the following steps: smashing the components in ultrasound; adding fermented culture medium and compound bacteria liquid; conducting enclosed anerobic fermentation at 36-37 DEG C for 12-14 h; adding a stabilizer in the fermented product; conducting vacuum low-temperature drying. The traditional Chinese medicine composition prepared from microbe fermentation acts with the microbe, is converted into components easy to be ingested and utilized by bodies, accelerates treating speed, improves curative effect, and micro-ecology environment of bodies, improves animal food return rate and performance trait, is used for preventing and treating chicken salmonellosis, can effectively relieve the symptom of diarrhea of chicken, eliminates or remarkably relieves inflammatory pathological injury of gastrointestinal tracts and cloaca, relieves potential safety hazards caused by chemical drugs, and improves safety of pharmacy.
Description
Technical field
The invention belongs to field of traditional Chinese veterinary, be specifically related to a kind of compound fermentation type Chinese medicine preventing and treating salmonellosis of chicken.
Background technology
Along with scale, the intensive development of modern poultry husbandry, due to the change of environment, weather, feeding and management, feed quality decline and the generation that the reasons such as infectiousness epidemic disease, hypoimmunity all can cause salmonellosis of chicken occur.Salmonellosis of chicken is by salmonellal a kind of septic infectious disease, this disease is main through ovum transmission, and digestive tract, respiratory tract all can infect, and chickling sickness rate, the mortality rate in 2 ~ 3 week age are the highest, hazard ratio is comparatively serious in recent years, becomes one of principal disease of puzzlement China poultry husbandry.December to April next year is epizootic modeling, and chickling group just starts death at 4 ages in days, and 7 ~ 15 age in days death peak.The laying hen group that grows up shows as laying rate at epidemic period and declines and dead increase, and mortality rate improves 2 ~ 3 times, lays eggs and can decline 5% ~ 30%.As opened the early stage morbidity of product, rise to about 70% in laying rate and namely start to decline, generally drop to 60% ~ 65%, what have even can drop to 50%, and most of stopping production chicken no longer recovers to lay eggs.Meanwhile, plant chicken incubation rate and also occur significantly declining, drop to 64.93% from premorbid 88.31%.Main manifestations is: chickling sickness rate is high, and mortality rate is the highest, become chicken mainly in recessive or chronic infection, but the chicken that carries disease germs causes vertical transmission, sick chicken manure just and sick chicken hatching egg be major source of infection.
From traditional Chinese veterinary medicine angle analysis, " exogenous pathogen mutual aid " is numerous disease predisposing factors, and when the five internal organs that namely traditional Chinese medical science is said are in " void ", virus is taken advantage of a weak point, and causes pathogen being excessive but vital QI weak, disease-resistant unable; Many because of the damp and hot fire-transformation of diseases caused by exogenous pathogenic factor, cause inhibited pulmonary QI, abnormal ascending-descending of QI, imbalance of YIN and YANG.Chinese herbal medicine can YIN and YANG balance regulating, treating both the principal and secondary aspects of a disease, make body constitutionally, immunity is thought and acted in one and the same way, equilibrium between yin and yang, thus reach the ideal cultivation state of " ill to send out less, morbidity die less ".Chinese veterinarian's disease therapy resists exopathogenic factor to invade by cultivating vigour in body the QI and blood change caused, and fundamentally can improve body constitution and promote rehabilitation, and doctor trained in Western medicine advocated solution disease for first modern age, alleviated apparent.Positive so-called Western medicine bactericidal antiphlogistic is controlled " mark ", Chinese medicine enhancing body anti pathologic immunity function, is positive controlling " basis ".Chinese medicine is natural green medicine, and not easily cause receptor drug resistance and sequela, noresidue ensures food safety.
The dosage form of the common use of current herbal medicine is Chinese powder medicine and oral liquid, modern herbal medicine theory is pointed out, a herb has nearly more than 300 plants active ingredient, usually can not play its due effect completely, can only be done some by escalated dose to make up, cause and utilize herbal medicine disease therapy high cost.The physiological characteristics intestinal of birds is short and small in addition, and content excreted at 3-4 hour, and make absorption not thorough, trap only has about 30%.
Summary of the invention
The object of this invention is to provide effect that one has heat clearing and damp drying, eliminating pathogenic heat from blood to cure dysentery, effectively can prevent and treat compound fermentation type Chinese medicine that salmonellosis of chicken and body microbial state treatment cause other virus of secondary and bacteria mixed infection disease.
The present invention realizes above-mentioned purpose by the following technical solutions: a kind of compound fermentation type Chinese medicine preventing and treating salmonellosis of chicken, it is prepared from by each component of following weight portion: Radix Pulsatillae 45-60, Rhizoma Atractylodis Macrocephalae 20-40, Rhizoma Coptidis 10-30, Cortex Phellodendri 10-30, Flos Caryophylli 5-15, Herba Pogostemonis 5-20, Herba Taraxaci 40-60, Radix Sophorae Flavescentis 10-30, Radix Gentianae 2-15, Herba Portulacae 10-30, scalding 5-20.
Prevent and treat a compound fermentation type Chinese medicine for salmonellosis of chicken, it is prepared from by each component of following weight portion: the Radix Pulsatillae 50, the Rhizoma Atractylodis Macrocephalae 30, Rhizoma Coptidis 20, Cortex Phellodendri 20, Flos Caryophylli 10, Herba Pogostemonis 10, Herba Taraxaci 50, Radix Sophorae Flavescentis 20, Radix Gentianae 10, Herba Portulacae 20, scalding 10.
Prevent and treat a preparation method for the compound fermentation type Chinese medicine of salmonellosis of chicken, concrete preparation process is 1. by each taste medicine ultrasonic grinding, crosses 80-100 mesh sieve, mix homogeneously; 2. the mixed-powder that 1. step obtains is added fermentation medium and compound bacteria bacterium liquid, 36-37 DEG C of closing anaerobic fermentation 16-18h, obtains tunning; 3. stabilizing agent is added, 0-4 DEG C of vacuum drying 12-14h in the tunning 2. obtained to step.
A kind of preparation method of preventing and treating the compound fermentation type Chinese medicine of salmonellosis of chicken, step 2. middle fermentation medium is made up of the component of following mass percent, in Chinese medicine gross mass for radix, wheat bran 20-30%, bean cake 3-4%, ammonium sulfate 1-2%, magnesium sulfate 0.5-1%, calcium carbonate 1-2%, water 20-30%.
Step 2. middle compound bacteria bacterium liquid is the 0.5-1.5% of Chinese medicine composition gross mass, the preparation method of compound bacteria bacterium liquid: a. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively, by the bacterium colony normal saline eluting that often kind of slant culture produces, add and increase amplification culture in bacterium cultured solution of broth, be cultured to exponential phase 0.5-1.0 × 10
8cFU/mL; B. the lactobacillus obtained by step a, yeast, streptococcus faecalis and bacillus amplification culture bacterium liquid are according to 2:(1-1.2): (0.8-1): (1-1.2) ratio is mixed to get composite bacteria liquid.
Step 3. middle stabilizing agent is preservative sodium benzoate and antioxidant propyl gallate, the addition of sodium benzoate is the 0.05-0.1% of step 2. gained tunning quality, and the addition of propyl gallate is the 0.005-0.008% of step 2. gained tunning quality.
Positive beneficial effect of the present invention:
In formula of the present invention, the Radix Pulsatillae, the Rhizoma Atractylodis Macrocephalae are monarch drug, Radix Pulsatillae bitter cold, return stomach warp, large intestine channel, heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, removing dampness and killing parasites; The bitter sweet temperature of the Rhizoma Atractylodis Macrocephalae, return spleen, stomach warp, invigorating the spleen and benefiting QI, dampness diuretic, two medicine mutual reinforcements between are use, eliminating pathogenic heat from blood to cure dysentery, dampness diuretic, Synergistic; Wherein the composition such as Anemonin, soaping agents, flavonoid has anti-multiple pathogenic microorganisms effect, and pharmacological action shows its prescription good kill bacteria effect.Cortex Phellodendri, Rhizoma Coptidis, Radix Sophorae Flavescentis are ministerial drug, and Cortex Phellodendri bitter cold, returns kidney, bladder, large intestine channel, heat clearing and damp drying, and pathogenic fire purging is except steaming; Rhizoma Coptidis bitter cold, GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel, heat clearing and damp drying, eliminating fire and detoxication; Radix Sophorae Flavescentis bitter cold, GUIXIN, liver, stomach, large intestine, urinary bladder channel, heat clearing and damp drying, parasite killing goes to amass, and three tastes share, and heat clearing and damp drying, pathogenic fire purging go to amass; Herba Taraxaci, Radix Gentianae, Herba Portulacae are adjuvant drug, bitter cold, inducing diuresis for treating stranguria syndrome, eliminating pathogenic heat from blood to cure dysentery; The pungent temperature of Flos Caryophylli, warming middle-JIAO warming the kidney, the pungent tepor of Herba Pogostemonis, removing dampness by means of aromatics, diarrhea due to summer heat and dampness, the pain relieving of Radix Paeoniae Alba suppressing the hyperactive liver, nourish blood yin fluid astringing, altogether for making medicine.
The present invention is by various Chinese medicine reasonable compatibility, science is extracted and is used, play the complementary action of different mechanism of action, there is wind and heat dispersing, removing pathogenic heat from blood and toxic substance from the body, antiinflammatory, heart tonifying, relieving asthma, improve immunity of organisms effect, enhance integrally-regulated function, for prevention and therapy salmonellosis of chicken, effectively can alleviate symptom of diarrhea, eliminate or obviously alleviate gastrointestinal tract, cloacal inflammatory pathology damage, alleviate the potential safety hazard that chemicals causes, add the safety of medication.
Composite fermentation Chinese medicinal ointment be Chinese herbal medicine through ultrasonic grinding, then add compound bacteria-fermented and form, the efficient composition such as albumen, tannin, starch in not removed Chinese herbal medicine, and these compositions play vital effect in treatment of diseases.Be converted into the composition that body is convenient to absorb with microbial action simultaneously, accelerate health care and treatment speed, improve health-care effect and curative effect, improve the microecological environment of body, improve animal spontaneous recovery and resistance against diseases, improve animal feed rate of returns and fertility performance.As can be seen here, compound fermentation Chinese medicine is greatly be better than other form of Chinese drug on pharmacological effect.
Invention advantage:
1, drug effect plays rapidly, and side effect is little, and treatment time is short, easy to use
The compound fermentation type Chinese medicine of control salmonellosis of chicken disclosed by the invention through ultrasonic grinding and cell wall wall breaking technology, then carries out micro-ecology fermentation, and effective ingredient is not destroyed, guarantee effective ingredient is sufficient, drug effect increases, and direct spice uses, and improves the microecological balance of body.Prove according to clinical trial, within latter 24 hours, observe from dispensing, mine massively appetite and spirit of chicken takes an evident turn for the better, after 48 hours, mortality rate declines to some extent, after 72 hours, feed intake and spirit recover normal substantially, and dissect the pathological changes incidence rate 85-95% lower than matched group of rear internal organs, and result as shown in Table 1.
2, persistent period that plays a role is long, and blood drug level is high, lasting medicine
Normal Chinese herbal medicine stops 2-6 hour at digestive system, and the compound fermentation type Chinese medicine of control salmonellosis of chicken disclosed by the invention is 8-12 hour in the effective time of birds digestive system, substantially prolongs the time of staying in intestinal, absorption rate significantly increases, through comparing, common Chinese (40-60 order) can detect a large amount of Chinese medicine prototypes after discharging with feces in intestinal, and the compound fermentation type Chinese medicine preventing and treating salmonellosis of chicken is after discharging through feces, almost can't check, minimal inhibitory concentration MIC also obviously differs simultaneously, compound fermentation type Chinese medicine MIC is higher than common Chinese by more than 95%.
3, with strong points, cure rate is high, and protective rate is high
Adopt advanced finger print identification technology, ensure that the quality of selected Chinese crude drug is excellent level, ensure the core technology of product, ensure quality and the curative effect of product.Throwing takes the compound fermentation type Chinese medicine of control salmonellosis of chicken disclosed by the invention and throws the broiler taking common Chinese, and after feeding 4 days, obviously occur difference, result as shown in Table 2.
Detailed description of the invention
Embodiment 1
Prevent and treat a compound fermentation type Chinese medicine for salmonellosis of chicken, it is prepared from by each component of following weight portion: Radix Pulsatillae 45-60, Rhizoma Atractylodis Macrocephalae 20-40, Rhizoma Coptidis 10-30, Cortex Phellodendri 10-30, Flos Caryophylli 5-15, Herba Pogostemonis 5-20, Herba Taraxaci 40-60, Radix Sophorae Flavescentis 10-30, Radix Gentianae 2-15, Herba Portulacae 10-30, scalding 5-20.
Prevent and treat a preparation method for the compound fermentation type Chinese medicine of salmonellosis of chicken, concrete preparation process is: 1. by each taste medicine ultrasonic grinding, crosses 80-100 mesh sieve, mix homogeneously;
2. the mixed-powder that 1. step obtains is added fermentation medium and compound bacteria bacterium liquid, 36-37 DEG C of closing anaerobic fermentation 16-18h, obtains tunning; Described fermentation medium is made up of the component of following mass percent, in Chinese medicine gross mass for radix, and wheat bran 20-30%, bean cake 3-4%, ammonium sulfate 1-2%, magnesium sulfate 0.5-1%, calcium carbonate 1-2%, water 20-30%; Compound bacteria bacterium liquid is the 0.5-1.5% of Chinese medicine composition gross mass, the preparation method of compound bacteria bacterium liquid: a. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively, by the bacterium colony normal saline eluting that often kind of slant culture produces, add and increase amplification culture in bacterium cultured solution of broth, be cultured to exponential phase 0.5-1.0 × 10
8cFU/mL; B. the lactobacillus obtained by step a, yeast, streptococcus faecalis and bacillus amplification culture bacterium liquid are according to 2:(1-1.2): (0.8-1): (1-1.2) ratio is mixed to get composite bacteria liquid;
3. stabilizing agent is added in the tunning 2. obtained to step, 0-4 DEG C of vacuum drying 12-14h, described stabilizing agent is preservative sodium benzoate and antioxidant propyl gallate, the addition of sodium benzoate is the 0.05-0.1% of tunning quality, and the addition of propyl gallate is the 0.005-0.008% of tunning quality.
Composite fermentation type Chinese medicine composition makes an addition in feedstuff in the 0.5-1% ratio of feeding quality, and mixing, throws something and feeds.
Embodiment 2
Prevent and treat a compound fermentation type Chinese medicine for salmonellosis of chicken, it is prepared from by each component of following weight portion: Radix Pulsatillae 50g, Rhizoma Atractylodis Macrocephalae 30g, Rhizoma Coptidis 20g, Cortex Phellodendri 20g, Flos Caryophylli 10g, Herba Pogostemonis 10g, Herba Taraxaci 50g, Radix Sophorae Flavescentis 20g, Radix Gentianae 10g, Herba Portulacae 20g, scalding 10g.
Prevent and treat a preparation method for the compound fermentation type Chinese medicine of salmonellosis of chicken, concrete preparation process is: 1. by each taste medicine ultrasonic grinding, crosses 80 mesh sieves, mix homogeneously;
2. the mixed-powder that 1. step obtains is added fermentation medium and compound bacteria bacterium liquid, 36 DEG C of closing anaerobic fermentation 16h, obtain tunning; Described fermentation medium is made up of the component of following mass percent, in Chinese medicine gross mass for radix, and wheat bran 25%, bean cake 4%, ammonium sulfate 2%, magnesium sulfate 0.5%, calcium carbonate 1.5%, water 25%; Compound bacteria bacterium liquid is 1% of Chinese medicine composition gross mass, the preparation method of compound bacteria bacterium liquid: a. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively, by the bacterium colony normal saline eluting that often kind of slant culture produces, add and increase amplification culture in bacterium cultured solution of broth, be cultured to exponential phase 0.8 × 10
8cFU/mL; B. lactobacillus obtained for step a, yeast, streptococcus faecalis and bacillus amplification culture bacterium liquid are mixed to get composite bacteria liquid according to 2:1:1:1 ratio;
3. stabilizing agent is added in the tunning 2. obtained to step, 0-4 DEG C of vacuum drying 12-14h, described stabilizing agent is preservative sodium benzoate and antioxidant propyl gallate, the addition of sodium benzoate is 0.08% of tunning quality, and the addition of propyl gallate is 0.005% of tunning quality.
Composite fermentation type Chinese medicine composition makes an addition in feedstuff in the 0.5-1% ratio of feeding quality, and mixing, throws something and feeds.
Embodiment 3
Prevent and treat a compound fermentation type Chinese medicine for salmonellosis of chicken, it is prepared from by each component of following weight portion: Radix Pulsatillae 47g, Rhizoma Atractylodis Macrocephalae 40g, Rhizoma Coptidis 18g, Cortex Phellodendri 10g, Flos Caryophylli 8g, Herba Pogostemonis 12g, Herba Taraxaci 44g, Radix Sophorae Flavescentis 15g, Radix Gentianae 9g, Herba Portulacae 10g, scalding 18g.
Prevent and treat a preparation method for the compound fermentation type Chinese medicine of salmonellosis of chicken, concrete preparation process is: 1. by each taste medicine ultrasonic grinding, crosses 100 mesh sieves, mix homogeneously;
2. the mixed-powder that 1. step obtains is added fermentation medium and compound bacteria bacterium liquid, 37 DEG C of closing anaerobic fermentation 18h, obtain tunning; Described fermentation medium is made up of the component of following mass percent, in Chinese medicine gross mass for radix, and wheat bran 20%, bean cake 3%, ammonium sulfate 1%, magnesium sulfate 1%, calcium carbonate 1%, water 20%; Compound bacteria bacterium liquid is 0.5% of Chinese medicine composition gross mass, the preparation method of compound bacteria bacterium liquid: a. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively, by the bacterium colony normal saline eluting that often kind of slant culture produces, add and increase amplification culture in bacterium cultured solution of broth, be cultured to exponential phase 0.5 × 10
8cFU/mL; B. lactobacillus obtained for step a, yeast, streptococcus faecalis and bacillus amplification culture bacterium liquid are mixed to get composite bacteria liquid according to 2:1.1:0.8:1 ratio;
3. stabilizing agent is added in the tunning 2. obtained to step, 4 DEG C of vacuum drying 12h, described stabilizing agent is preservative sodium benzoate and antioxidant propyl gallate, the addition of sodium benzoate is 0.05% of tunning quality, and the addition of propyl gallate is 0.006% of tunning quality.
Composite fermentation type Chinese medicine composition makes an addition in feedstuff in the 0.5-1% ratio of feeding quality, and mixing, throws something and feeds.
Embodiment 4
Prevent and treat a compound fermentation type Chinese medicine for salmonellosis of chicken, it is prepared from by each component of following weight portion: Radix Pulsatillae 45g, Rhizoma Atractylodis Macrocephalae 38g, Rhizoma Coptidis 15g, Cortex Phellodendri 12g, Flos Caryophylli 12g, Herba Pogostemonis 20g, Herba Taraxaci 47g, Radix Sophorae Flavescentis 10g, Radix Gentianae 15g, Herba Portulacae 30g, scalding 5g.
Prevent and treat a preparation method for the compound fermentation type Chinese medicine of salmonellosis of chicken, concrete preparation process is: 1. by each taste medicine ultrasonic grinding, crosses 90 mesh sieves, mix homogeneously;
2. the mixed-powder that 1. step obtains is added fermentation medium and compound bacteria bacterium liquid, 36 DEG C of closing anaerobic fermentation 17h, obtain tunning; Described fermentation medium is made up of the component of following mass percent, in Chinese medicine gross mass for radix, and wheat bran 30%, bean cake 3.5%, ammonium sulfate 1.5%, magnesium sulfate 1%, calcium carbonate 2%, water 30%; Compound bacteria bacterium liquid is 1.5% of Chinese medicine composition gross mass, the preparation method of compound bacteria bacterium liquid: a. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively, by the bacterium colony normal saline eluting that often kind of slant culture produces, add and increase amplification culture in bacterium cultured solution of broth, be cultured to exponential phase 1.0 × 10
8cFU/mL; B. lactobacillus obtained for step a, yeast, streptococcus faecalis and bacillus amplification culture bacterium liquid are mixed to get composite bacteria liquid according to 2:1.2:0.9:1.1 ratio;
3. stabilizing agent is added in the tunning 2. obtained to step, 0 DEG C of vacuum drying 14h, described stabilizing agent is preservative sodium benzoate and antioxidant propyl gallate, the addition of sodium benzoate is 0.1% of tunning quality, and the addition of propyl gallate is 0.008% of tunning quality.
Composite fermentation type Chinese medicine composition makes an addition in feedstuff in the 0.5-1% ratio of feeding quality, and mixing, throws something and feeds.
Embodiment 5
Prevent and treat a compound fermentation type Chinese medicine for salmonellosis of chicken, it is prepared from by each component of following weight portion: Radix Pulsatillae 49g, Rhizoma Atractylodis Macrocephalae 35g, Rhizoma Coptidis 22g, Cortex Phellodendri 26g, Flos Caryophylli 13g, Herba Pogostemonis 5g, Herba Taraxaci 51g, Radix Sophorae Flavescentis 30g, Radix Gentianae 13g, Herba Portulacae 12g, scalding 7g.
Prevent and treat a preparation method for the compound fermentation type Chinese medicine of salmonellosis of chicken, concrete preparation process is: 1. by each taste medicine ultrasonic grinding, crosses 80 mesh sieves, mix homogeneously;
2. the mixed-powder that 1. step obtains is added fermentation medium and compound bacteria bacterium liquid, 37 DEG C of closing anaerobic fermentation 18h, obtain tunning; Described fermentation medium is made up of the component of following mass percent, in Chinese medicine gross mass for radix, and wheat bran 23%, bean cake 3%, ammonium sulfate 2%, magnesium sulfate 0.5%, calcium carbonate 1.5%, water 25%; Compound bacteria bacterium liquid is 1% of Chinese medicine composition gross mass, the preparation method of compound bacteria bacterium liquid: a. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively, by the bacterium colony normal saline eluting that often kind of slant culture produces, add and increase amplification culture in bacterium cultured solution of broth, be cultured to exponential phase 0.8 × 10
8cFU/mL; B. lactobacillus obtained for step a, yeast, streptococcus faecalis and bacillus amplification culture bacterium liquid are mixed to get composite bacteria liquid according to 2:1:1:1 ratio;
3. stabilizing agent is added in the tunning 2. obtained to step, 0-4 DEG C of vacuum drying 13h, described stabilizing agent is preservative sodium benzoate and antioxidant propyl gallate, the addition of sodium benzoate is 0.08% of tunning quality, and the addition of propyl gallate is 0.005% of tunning quality.
Composite fermentation type Chinese medicine composition makes an addition in feedstuff in the 0.5-1% ratio of feeding quality, and mixing, throws something and feeds.
Embodiment 6
Prevent and treat a compound fermentation type Chinese medicine for salmonellosis of chicken, it is prepared from by each component of following weight portion: Radix Pulsatillae 58g, Rhizoma Atractylodis Macrocephalae 33g, Rhizoma Coptidis 24g, Cortex Phellodendri 15g, Flos Caryophylli 5g, Herba Pogostemonis 14g, Herba Taraxaci 42g, Radix Sophorae Flavescentis 12g, Radix Gentianae 11g, Herba Portulacae 25g, scalding 9g.
The preparation method of compound fermentation type Chinese medicine and usage and dosage are with embodiment 1.
Embodiment 7
Prevent and treat a compound fermentation type Chinese medicine for salmonellosis of chicken, it is prepared from by each component of following weight portion: Radix Pulsatillae 60g, Rhizoma Atractylodis Macrocephalae 22g, Rhizoma Coptidis 27g, Cortex Phellodendri 28g, Flos Caryophylli 6g, Herba Pogostemonis 6g, Herba Taraxaci 40g, Radix Sophorae Flavescentis 28g, Radix Gentianae 8g, Herba Portulacae 15g, scalding 12g.
The preparation method of compound fermentation type Chinese medicine and usage and dosage are with embodiment 1.
Embodiment 8
Prevent and treat a compound fermentation type Chinese medicine for salmonellosis of chicken, it is prepared from by each component of following weight portion: Radix Pulsatillae 56g, Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Coptidis 30g, Cortex Phellodendri 18g, Flos Caryophylli 90g, Herba Pogostemonis 9g, Herba Taraxaci 58g, Radix Sophorae Flavescentis 25g, Radix Gentianae 2g, Herba Portulacae 18g, scalding 15g.
The preparation method of compound fermentation type Chinese medicine and usage and dosage are with embodiment 1.
Embodiment 9
Prevent and treat a compound fermentation type Chinese medicine for salmonellosis of chicken, it is prepared from by each component of following weight portion: Radix Pulsatillae 54g, Rhizoma Atractylodis Macrocephalae 24g, Rhizoma Coptidis 10g, Cortex Phellodendri 30g, Flos Caryophylli 15g, Herba Pogostemonis 15g, Herba Taraxaci 60g, Radix Sophorae Flavescentis 18g, Radix Gentianae 4g, Herba Portulacae 22g, scalding 16g.
The preparation method of compound fermentation type Chinese medicine and usage and dosage are with embodiment 1.
Embodiment 10
Prevent and treat a compound fermentation type Chinese medicine for salmonellosis of chicken, it is prepared from by each component of following weight portion: Radix Pulsatillae 52g, Rhizoma Atractylodis Macrocephalae 27g, Rhizoma Coptidis 13g, Cortex Phellodendri 23g, Flos Caryophylli 14g, Herba Pogostemonis 18g, Herba Taraxaci 54g, Radix Sophorae Flavescentis 22g, Radix Gentianae 7g, Herba Portulacae 27g, scalding 20g.
The preparation method of compound fermentation type Chinese medicine and usage and dosage are with embodiment 1.
Test example 1
Jiaozhuo, Henan plant 32 Japanese instar chickling, about 3000 chickling morbidities, the how weak young bird of clinical manifestation, 5-7 age in days symptom is obvious, the asymptomatic death had, be afraid of cold, bunch, two wings are sagging, appetite is absolutely useless, draw white, yellowish, light green stickiness loose stool, feces adhesion crissum, defecation difficulty, dyspnea, malnutrition.Pathological change performance enteritis, hepatomegaly, in khaki, yolk does not absorb or malabsorption, and in yellow-white bean curd slag specimen, the adularescent lesser tubercle such as conscience, abdominal viscera is coated with cellulose sample thing, and kidney is dark violet or pale, is Salmonella pullorum disease after diagnosing.
Compound fermentation type Chinese medicine prepared by application the present invention is treated, and makes an addition in feedstuff by compound fermentation type Chinese medicine according to the 0.5-1% of feeding quality, and mixing, throws something and feeds, and carries out strict sterilization process before and after treatment to colony house.Medication is after 3 days, and clinical symptoms and the mental status of sick chicken are clearly better, and medication is after 5 days, and 2857 sick chickens get well, clinical symptom disappearance, and cure rate reaches 95.23%, cures and pays a return visit after one month, and the sick chicken of rehabilitation is not recurred again.
General formulation Chinese medicine prepared by the formula that application the present invention announces is treated, medication is after 6 days, clinical symptoms and the mental status of sick chicken are clearly better, medication is after 10 days, 2731 sick chickens get well, clinical symptom disappearance, and cure rate reaches 91.03%, cure and pay a return visit after one month, the sick chicken of rehabilitation has indivedual recurrence.
Test example 2
There is epidemic situation in certain body raiser laying hen, one 2500, the laying hen of 280 ages in days occurs that obvious chicken egg productivity reduces, and soft-shelled egg increases, and eggshell color shoals, and rate of fertilization, incubation rate, strong young rate decline to a great extent, malnutrition.Pathological change performance grow up Ovary atrophy, distortion, yolk be cyan or black degeneration, and tangent plane is cheesy, have with pericarditis, be after diagnosing Salmonella pullorum disease infection.
The compound fermentation type Chinese medicine composition applying control salmonellosis of chicken disclosed by the invention is treated, compound fermentation type Chinese medicine is made an addition in feedstuff according to the 0.5-1% of feeding quality, mixing, throws something and feeds, and carries out strict sterilization before and after treatment to hen house and surrounding.After 3 days, chicken is mined massively that appetite rises, egg drop reduction slows down in medication, and medication is after 5 days, and lay eggs and start to recover, shell egg recovers normal substantially, and through medication in 10 days, lay eggs and return to former 95%, cure rate reached 99.5%, and cure return visit in latter three months, rehabilitation chicken group does not fall ill again.
Apply general formulation Chinese medicine composition prepared by formula disclosed by the invention to treat, after 5 days, chicken is mined massively that appetite rises, egg drop reduction slows down in medication, medication is after 10 days, lay eggs and start to recover, shell egg recovered normal substantially, through medication in 15 days, lay eggs and return to former 88%, cure rate reaches 91.13%, and cure return visit in latter three months, rehabilitation chicken group has indivedual recurrence.
Claims (6)
1. prevent and treat a compound fermentation type Chinese medicine for salmonellosis of chicken, it is characterized in that it is prepared from by each component of following weight portion: Radix Pulsatillae 45-60, Rhizoma Atractylodis Macrocephalae 20-40, Rhizoma Coptidis 10-30, Cortex Phellodendri 10-30, Flos Caryophylli 5-15, Herba Pogostemonis 5-20, Herba Taraxaci 40-60, Radix Sophorae Flavescentis 10-30, Radix Gentianae 2-15, Herba Portulacae 10-30, scalding 5-20.
2. a kind of compound fermentation type Chinese medicine preventing and treating salmonellosis of chicken according to claim 1, is characterized in that it is prepared from by each component of following weight portion: the Radix Pulsatillae 50, the Rhizoma Atractylodis Macrocephalae 30, Rhizoma Coptidis 20, Cortex Phellodendri 20, Flos Caryophylli 10, Herba Pogostemonis 10, Herba Taraxaci 50, Radix Sophorae Flavescentis 20, Radix Gentianae 10, Herba Portulacae 20, scalding 10.
3. a kind of preparation method of preventing and treating the compound fermentation type Chinese medicine of salmonellosis of chicken according to claim 1 or 2, is characterized in that: concrete preparation process is 1. by each taste medicine ultrasonic grinding, crosses 80-100 mesh sieve, mix homogeneously; 2. the mixed-powder that 1. step obtains is added fermentation medium and compound bacteria bacterium liquid, 36-37 DEG C of closing anaerobic fermentation 16-18h, obtains tunning; 3. stabilizing agent is added, 0-4 DEG C of vacuum drying 12-14h in the tunning 2. obtained to step.
4. a kind of preparation method of preventing and treating the compound fermentation type Chinese medicine of salmonellosis of chicken according to claim 3, it is characterized in that: step 2. middle fermentation medium is made up of the component of following mass percent, in Chinese medicine gross mass for radix, wheat bran 20-30%, bean cake 3-4%, ammonium sulfate 1-2%, magnesium sulfate 0.5-1%, calcium carbonate 1-2%, water 20-30%.
5. a kind of preparation method of preventing and treating the compound fermentation type Chinese medicine of salmonellosis of chicken according to claim 3, it is characterized in that: step 2. middle compound bacteria bacterium liquid is the 0.5-1.5% of Chinese medicine composition gross mass, the preparation method of compound bacteria bacterium liquid: a. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively, by the bacterium colony normal saline eluting that often kind of slant culture produces, add and increase amplification culture in bacterium cultured solution of broth, be cultured to exponential phase 0.5-1.0 × 10
8cFU/mL; B. the lactobacillus obtained by step a, yeast, streptococcus faecalis and bacillus amplification culture bacterium liquid are according to 2:(1-1.2): (0.8-1): (1-1.2) ratio is mixed to get composite bacteria liquid.
6. a kind of preparation method of preventing and treating the compound fermentation type Chinese medicine of salmonellosis of chicken according to claim 3, it is characterized in that: step 3. middle stabilizing agent is preservative sodium benzoate and antioxidant propyl gallate, the addition of sodium benzoate is the 0.05-0.1% of step 2. gained tunning quality, and the addition of propyl gallate is the 0.005-0.008% of step 2. gained tunning quality.
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Application publication date: 20150429 |