CN104547137A - Composite fermented traditional Chinese medicine composition for preventing and treating chicken infectious bursal disease - Google Patents
Composite fermented traditional Chinese medicine composition for preventing and treating chicken infectious bursal disease Download PDFInfo
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Abstract
The invention discloses a composite fermented traditional Chinese medicine composition for preventing and treating a chicken infectious bursal disease. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 25-40 parts of radix isatidis, 25-40 parts of gynostemma pentaphylla, 30-50 parts of dandelion, 10-30 parts of honeysuckle, 50-70 parts of mugwort leaf, 30-50 parts of herba andrographitis, 1-8 parts of toad-cortex, 2-8 parts of borneol, 5-18 parts of liquorice, and 5-20 parts of munjeet. The traditional Chinese medicine composition is prepared from the following steps: smashing the components in ultrasound; adding fermented culture medium and compound bacteria liquid; conducting enclosed anerobic fermentation at 36-37 DEG C for 12-14 h; adding a stabilizer in the fermented product; conducting vacuum low-temperature drying. The traditional Chinese medicine composition prepared from microbe fermentation acts with the microbe, is converted into components easy to be ingested and utilized by bodies, accelerates treating speed, improves curative effect, and micro-ecology environment of bodies, improves animal food return rate and performance trait, can effectively relieve, eliminate or remarkably relieve symptoms of bleeding, death and the like caused by chicken infectious bursal disease, reduces pathological damage of bursa of Fabricius, milt and the like, relieves potential safety hazards caused by chemical drugs, and improves safety of pharmacy.
Description
Technical field
The invention belongs to field of traditional Chinese veterinary, be specifically related to a kind of compound fermentation type Chinese medicine composition preventing and treating infectious bursal disease.
Background technology
In scale in modern chicken farm, intensivization development process; due to the exception of environment, weather, the reasons such as feeding and management, the going mouldy of feedstuff, the improper use of immunosuppressive disease vaccine all can cause the acute outburst of infectious bursal disease and chronic atypia to occur, but occur as master with atypia; main manifestations is: sick chicken spirit is depressed; feed intake reduces, and drinking-water increases, and some is from anus pecking door; arrange white water sample loose stool; severe one is dewatered, and does not rise sleepingly, extremely feeble, finally death.Resistance to chicken performance anemia of crossing is become thin, poor growth.Cut open inspection visible: fabricius bursa occurrence characteristics sexually transmitted disease (STD) becomes, fabricius bursa be yellow glue peptone sample edema, matter firmly, mucosa is coated with cream-colored fibrinous exudate.Sometimes fabricius bursa mucosa severe inflammation, hemorrhage, downright bad, atrophy.In addition, the chicken that dies of illness performance dehydration, lower limb and chest muscle often have hemorrhage, and color is dark red; Renal swelling is swollen, and renal tubules and ureter are full of white urate; Spleen and glandular stomach and muscular stomach intersection mucosal bleeding.Because primary disease mainly encroaches on the immune system of poultry, although the mortality rate caused is not high, easily cause other epidemic diseases of chicken group as the outburst of newcastle, colibacillosis etc. and popular.
Chinese veterinarian's disease therapy is resist exopathogenic factor to invade by cultivating vigour in body the QI and blood change caused substantially, fundamentally can improve body constitution and promote rehabilitation, and doctor trained in Western medicine advocated solution disease for first modern age, alleviated apparent.Positive so-called Western medicine bactericidal antiphlogistic is controlled " mark ", Chinese medicine enhancing body anti pathologic immunity function, is positive controlling " basis ".Chinese medicine is natural green medicine, and not easily cause receptor drug resistance and sequela, noresidue ensures food safety.
Current herbal medicine common dosage forms is Chinese powder medicine and oral liquid, modern herbal medicine theory is pointed out, a herb has nearly more than 300 plants active ingredient, usually can not play its due effect completely, can only be done some by escalated dose to make up, cause and utilize herbal medicine disease therapy high cost.The physiological characteristics intestinal of birds is short and small in addition, and content excreted at 3-4 hour, and make absorption not thorough, trap only has about 30%.
Summary of the invention
The object of this invention is to provide effect that one has heat-clearing and toxic substances removing, reducing swelling and alleviating pain, warming the meridian for stopping bleeding, effectively can prevent and treat the Composite fermentation type Chinese medicine composition of infectious bursal disease.
The present invention realizes above-mentioned purpose by the following technical solutions: a kind of Composite fermentation type Chinese medicine composition preventing and treating infectious bursal disease, and it is prepared from by each component of following weight portion: Radix Isatidis 25-40, Herb Gynostemmae Pentaphylli 25-40, Herba Taraxaci 30-50, Flos Lonicerae 10-30, Folium Artemisiae Argyi 50-70, Herba Andrographis 30-50, toad clothing 1-8, Borneolum Syntheticum 2-8, Radix Glycyrrhizae 5-18, Radix Rubiae 5-20.
Prevent and treat a Composite fermentation type Chinese medicine composition for infectious bursal disease, it is prepared from by each component of following weight portion: Radix Isatidis 30, Herb Gynostemmae Pentaphylli 30, Herba Taraxaci 40, Flos Lonicerae 20, Folium Artemisiae Argyi 60, Herba Andrographis 40, toad clothing 5, Borneolum Syntheticum 5, Radix Glycyrrhizae 10, Radix Rubiae 10.
Prevent and treat a preparation method for the Composite fermentation type Chinese medicine composition of infectious bursal disease, concrete preparation process is 1. by each taste medicine ultrasonic grinding, crosses 80-100 mesh sieve, mix homogeneously; 2. the mixed-powder that 1. step obtains is added fermentation medium and compound bacteria bacterium liquid, 36-37 DEG C of closing anaerobic fermentation 12-14h, obtains tunning; 3. stabilizing agent is added, 0-4 DEG C of vacuum drying 12-14h in the tunning 2. obtained to step.
Step 2. middle fermentation medium is made up of the component of following mass percent, in Chinese medicine gross mass for radix, and wheat bran 20-30%, bean cake 3-4%, ammonium sulfate 1-2%, magnesium sulfate 0.5-1%, calcium carbonate 1-2%, water 20-30%.
Step 2. middle compound bacteria bacterium liquid is the 0.5-1.5% of Chinese medicine composition gross mass, the preparation method of compound bacteria bacterium liquid: a. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively, by the bacterium colony normal saline eluting that often kind of slant culture produces, add and increase amplification culture in bacterium cultured solution of broth, be cultured to exponential phase 0.5-1.0 × 10
8cFU/mL; B. the lactobacillus obtained by step a, yeast, streptococcus faecalis and bacillus amplification culture bacterium liquid are according to 2:(1-1.2): (0.8-1): (1-1.2) ratio is mixed to get composite bacteria liquid.
Step 3. middle stabilizing agent is preservative sodium benzoate and antioxidant propyl gallate, the addition of sodium benzoate is the 0.05-0.1% of step 2. gained tunning quality, and the addition of propyl gallate is the 0.005-0.008% of step 2. gained tunning quality.
Chinese medicine prescription combines with Modern microbiological technology and prepares a kind of traditional Chinese biological preparation by the present invention, said preparation is for raw material with Chinese medicine Lentinus Edodes, Radix Ophiopogonis, Herba Apocyni veneti, Herb Gynostemmae Pentaphylli, the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Herba Leonuri, Radix Glycyrrhizae, wheat bran, bean cake, ammonium sulfate, magnesium sulfate, calcium carbonate and suitable quantity of water composition fermentation medium is added after ultrasonic grinding, add a certain proportion of compound bacteria bacteria culture fluid, ferment, ripe solid fermentation thing adds stabilizing agent, carries out cold drying and is prepared from.Traditional Chinese biological preparation prepared after fermentable metabolism, albumen in not removed Chinese herbal medicine, tannin, the efficient composition such as starch, and these compositions play vital effect in treatment of diseases, be converted into the composition that body is convenient to absorb with microbial action simultaneously, accelerate treatment speed, improve curative effect, improve the microecological environment of body, improve animal spontaneous recovery and resistance against diseases, improve animal feed rate of returns and fertility performance, can effectively alleviate, eliminate or obviously alleviate that infectious bursal disease causes hemorrhage, death waits disease, reduce fabricius bursa, the pathology damage of spleen etc., alleviate the potential safety hazard that chemical medicine causes, add the safety of medication.As can be seen here, compound fermentation Chinese medicine is greatly be better than other form of Chinese drug on pharmacological effect.
In formula of the present invention, Radix Isatidis, Herb Gynostemmae Pentaphylli, Herba Taraxaci are monarch drug, Radix Isatidis bitter cold, GUIXIN, stomach warp, heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving; Herb Gynostemmae Pentaphylli is bitter cool micro-sweet, returns lung; Spleen; Kidney channel, replenishing QI to invigorate the spleen, heat-clearing and toxic substances removing, preventing phlegm from forming and stopping coughing; Herba Taraxaci is bitter sweet cold, and enter liver, stomach warp, heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome, three medicine mutual reinforcements between are use, QI invigorating removing heat from blood, dispersing swelling and dissipating binds, Synergistic; Flos Lonicerae, Folium Artemisiae Argyi are ministerial drug, and Flos Lonicerae is sweet cold, enters lung, the heart, stomach warp, heat-clearing and toxic substances removing, heat radiation dispelling wind; The arduous temperature of Folium Artemisiae Argyi, enter spleen, liver, kidney channel, dispersing cold for relieving pain, warming the meridian for stopping bleeding, antiabortive, wet down parasite killing, two medicines share, heat radiation dispelling wind, analgesic hemostatic; Herba Andrographis, toad clothing, Borneolum Syntheticum are adjuvant drug, bitter cold, sensible refreshment, reducing swelling and alleviating pain; Radix Rubiae blood stasis dispelling stimulates the menstrual flow, and Radix Glycyrrhizae is sweet flat, and replenishing QI to invigorate the spleen, invigorating the spleen and replenishing QI, coordinating the actions of various ingredients in a prescription, altogether for making medicine.
The present invention has wind and heat dispersing, removing pathogenic heat from blood and toxic substance from the body, antiinflammatory, heart tonifying, relieving asthma, improve immunity of organisms effect, full side science of being carried out by various Chinese medicine reasonable compatibility is extracted and is used, play the complementary action of different mechanism of action, thus play the effect of stronger antibacterial, antiviral, raising immunity, can effectively treat poultry infectious bursal disease, have effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, warming the meridian for stopping bleeding.
Positive beneficial effect of the present invention:
1, drug effect plays rapidly, and side effect is little, and treatment time is short, easy to use
The Composite fermentation type Chinese medicine composition of control infectious bursal disease disclosed by the invention is through ultrasonic grinding and cell wall wall breaking technology, carry out micro-ecology fermentation again, effective ingredient is not destroyed, guarantee effective ingredient is sufficient, drug effect increases, direct spice uses, and improves the microecological balance of body.Prove according to clinical trial, within latter 24 hours, observe from dispensing, mine massively appetite and spirit of chicken takes an evident turn for the better, after 48 hours, mortality rate declines to some extent, after 72 hours, feed intake and spirit recover normal substantially, and dissect the pathological changes incidence rate 85-95% lower than matched group of rear internal organs, and result as shown in Table 1.
2, persistent period that plays a role is long, and blood drug level is high, lasting medicine
Normal Chinese herbal medicine stops 2-6 hour at chicken digestive system, and the Composite fermentation type Chinese medicine composition of control infectious bursal disease disclosed by the invention, be 8-12 hour in the effective time of birds digestive system, substantially prolongs the time of staying in intestinal, absorption rate significantly increases, through comparing, common Chinese (40-60 order) can detect a large amount of Chinese medicine prototypes after discharging with feces in intestinal, and the Composite fermentation type Chinese medicine composition preventing and treating infectious bursal disease is after discharging through feces, almost can't check, minimal inhibitory concentration MIC also obviously differs simultaneously, MIC is higher than common Chinese herbal medicine by more than 95%.
3, with strong points, cure rate is high, and protective rate is high
Adopt advanced finger print identification technology, ensure that the quality of selected Chinese crude drug is excellent level, ensure the core technology of product, ensure quality and the curative effect of product.Throw and take Composite fermentation type Chinese medicine composition disclosed by the invention and throw the broiler taking common Chinese, after feeding 4 days, obviously occur difference, result as shown in Table 2.
Detailed description of the invention
Embodiment 1
Prevent and treat a Composite fermentation type Chinese medicine composition for infectious bursal disease, it is prepared from by each component of following weight portion: Radix Isatidis 25-40, Herb Gynostemmae Pentaphylli 25-40, Herba Taraxaci 30-50, Flos Lonicerae 10-30, Folium Artemisiae Argyi 50-70, Herba Andrographis 30-50, toad clothing 1-8, Borneolum Syntheticum 2-5, Radix Glycyrrhizae 5-18, Radix Rubiae 5-20.
Prevent and treat a preparation method for the Composite fermentation type Chinese medicine composition of infectious bursal disease, concrete preparation process is: 1. by each taste medicine ultrasonic grinding, crosses 80-100 mesh sieve, mix homogeneously;
2. the mixed-powder that 1. step obtains is added fermentation medium and compound bacteria bacterium liquid, 36-37 DEG C of closing anaerobic fermentation 12-14h, obtains tunning; Described fermentation medium is made up of the component of following mass percent, in Chinese medicine gross mass for radix, and wheat bran 20-30%, bean cake 3-4%, ammonium sulfate 1-2%, magnesium sulfate 0.5-1%, calcium carbonate 1-2%, water 20-30%; Compound bacteria bacterium liquid is the 0.5-1.5% of Chinese medicine composition gross mass, the preparation method of compound bacteria bacterium liquid: a. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively, by the bacterium colony normal saline eluting that often kind of slant culture produces, add and increase amplification culture in bacterium cultured solution of broth, be cultured to exponential phase 0.5-1.0 × 10
8cFU/mL; B. the lactobacillus obtained by step a, yeast, streptococcus faecalis and bacillus amplification culture bacterium liquid are according to 2:(1-1.2): (0.8-1): (1-1.2) ratio is mixed to get composite bacteria liquid;
3. stabilizing agent is added in the tunning 2. obtained to step, 0-4 DEG C of vacuum drying 12-14h, described stabilizing agent is preservative sodium benzoate and antioxidant propyl gallate, the addition of sodium benzoate is the 0.05-0.1% of tunning quality, and the addition of propyl gallate is the 0.005-0.008% of tunning quality.
Composite fermentation type Chinese medicine composition makes an addition in feedstuff in the 0.5-1% ratio of feeding quality, and mixing, throws something and feeds.
Embodiment 2
Prevent and treat a Composite fermentation type Chinese medicine composition for infectious bursal disease, it is prepared from by each component of following weight portion: Radix Isatidis 30g, Herb Gynostemmae Pentaphylli 30g, Herba Taraxaci 40g, Flos Lonicerae 20g, Folium Artemisiae Argyi 60g, Herba Andrographis 40g, toad clothing 5g, Borneolum Syntheticum 5g, Radix Glycyrrhizae 10g, Radix Rubiae 10g.
Prevent and treat a preparation method for the Composite fermentation type Chinese medicine composition of infectious bursal disease, concrete preparation process is: 1. by each taste medicine ultrasonic grinding, crosses 80 mesh sieves, mix homogeneously;
2. the mixed-powder that 1. step obtains is added fermentation medium and compound bacteria bacterium liquid, 36 DEG C of closing anaerobic fermentation 16h, obtain tunning; Described fermentation medium is made up of the component of following mass percent, in Chinese medicine gross mass for radix, and wheat bran 25%, bean cake 4%, ammonium sulfate 2%, magnesium sulfate 0.5%, calcium carbonate 1.5%, water 25%; Compound bacteria bacterium liquid is 1% of Chinese medicine composition gross mass, the preparation method of compound bacteria bacterium liquid: a. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively, by the bacterium colony normal saline eluting that often kind of slant culture produces, add and increase amplification culture in bacterium cultured solution of broth, be cultured to exponential phase 0.8 × 10
8cFU/mL; B. lactobacillus obtained for step a, yeast, streptococcus faecalis and bacillus amplification culture bacterium liquid are mixed to get composite bacteria liquid according to 2:1:1:1 ratio;
3. stabilizing agent is added in the tunning 2. obtained to step, 0-4 DEG C of vacuum drying 12-14h, described stabilizing agent is preservative sodium benzoate and antioxidant propyl gallate, the addition of sodium benzoate is 0.08% of tunning quality, and the addition of propyl gallate is 0.005% of tunning quality.
Composite fermentation type Chinese medicine composition makes an addition in feedstuff in the 0.5-1% ratio of feeding quality, and mixing, throws something and feeds.
Embodiment 3
Prevent and treat a Composite fermentation type Chinese medicine composition for infectious bursal disease, it is prepared from by each component of following weight portion: Radix Isatidis 25g, Herb Gynostemmae Pentaphylli 40g, Herba Taraxaci 35g, Flos Lonicerae 18g, Folium Artemisiae Argyi 55g, Herba Andrographis 38g, toad clothing 4g, Borneolum Syntheticum 2g, Radix Glycyrrhizae 15g, Radix Rubiae 12g.
Prevent and treat a preparation method for the Composite fermentation type Chinese medicine composition of infectious bursal disease, concrete preparation process is: 1. by each taste medicine ultrasonic grinding, crosses 100 mesh sieves, mix homogeneously;
2. the mixed-powder that 1. step obtains is added fermentation medium and compound bacteria bacterium liquid, 37 DEG C of closing anaerobic fermentation 18h, obtain tunning; Described fermentation medium is made up of the component of following mass percent, in Chinese medicine gross mass for radix, and wheat bran 20%, bean cake 3%, ammonium sulfate 1%, magnesium sulfate 1%, calcium carbonate 1%, water 20%; Compound bacteria bacterium liquid is 0.5% of Chinese medicine composition gross mass, the preparation method of compound bacteria bacterium liquid: a. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively, by the bacterium colony normal saline eluting that often kind of slant culture produces, add and increase amplification culture in bacterium cultured solution of broth, be cultured to exponential phase 0.5 × 10
8cFU/mL; B. lactobacillus obtained for step a, yeast, streptococcus faecalis and bacillus amplification culture bacterium liquid are mixed to get composite bacteria liquid according to 2:1.1:0.8:1 ratio;
3. stabilizing agent is added in the tunning 2. obtained to step, 4 DEG C of vacuum drying 12h, described stabilizing agent is preservative sodium benzoate and antioxidant propyl gallate, the addition of sodium benzoate is 0.05% of tunning quality, and the addition of propyl gallate is 0.006% of tunning quality.
Composite fermentation type Chinese medicine composition makes an addition in feedstuff in the 0.5-1% ratio of feeding quality, and mixing, throws something and feeds.
Embodiment 4
Prevent and treat a Composite fermentation type Chinese medicine composition for infectious bursal disease, it is prepared from by each component of following weight portion: Radix Isatidis 27g, Herb Gynostemmae Pentaphylli 37g, Herba Taraxaci 33g, Flos Lonicerae 10g, Folium Artemisiae Argyi 52g, Herba Andrographis 32g, toad clothing 8g, Borneolum Syntheticum 7g, Radix Glycyrrhizae 10g, Radix Rubiae 14g.
Prevent and treat a preparation method for the Composite fermentation type Chinese medicine composition of infectious bursal disease, concrete preparation process is: 1. by each taste medicine ultrasonic grinding, crosses 90 mesh sieves, mix homogeneously;
2. the mixed-powder that 1. step obtains is added fermentation medium and compound bacteria bacterium liquid, 36 DEG C of closing anaerobic fermentation 17h, obtain tunning; Described fermentation medium is made up of the component of following mass percent, in Chinese medicine gross mass for radix, and wheat bran 30%, bean cake 3.5%, ammonium sulfate 1.5%, magnesium sulfate 1%, calcium carbonate 2%, water 30%; Compound bacteria bacterium liquid is 1.5% of Chinese medicine composition gross mass, the preparation method of compound bacteria bacterium liquid: a. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively, by the bacterium colony normal saline eluting that often kind of slant culture produces, add and increase amplification culture in bacterium cultured solution of broth, be cultured to exponential phase 1.0 × 10
8cFU/mL; B. lactobacillus obtained for step a, yeast, streptococcus faecalis and bacillus amplification culture bacterium liquid are mixed to get composite bacteria liquid according to 2:1.2:0.9:1.1 ratio;
3. stabilizing agent is added in the tunning 2. obtained to step, 0 DEG C of vacuum drying 14h, described stabilizing agent is preservative sodium benzoate and antioxidant propyl gallate, the addition of sodium benzoate is 0.1% of tunning quality, and the addition of propyl gallate is 0.008% of tunning quality.
Composite fermentation type Chinese medicine composition makes an addition in feedstuff in the 0.5-1% ratio of feeding quality, and mixing, throws something and feeds.
Embodiment 5
Prevent and treat a Composite fermentation type Chinese medicine composition for infectious bursal disease, it is prepared from by each component of following weight portion: Radix Isatidis 29g, Herb Gynostemmae Pentaphylli 38g, Herba Taraxaci 30g, Flos Lonicerae 13g, Folium Artemisiae Argyi 63g, Herba Andrographis 43g, toad clothing 2g, Borneolum Syntheticum 3g, Radix Glycyrrhizae 12g, Radix Rubiae 15g.
Prevent and treat a preparation method for the Composite fermentation type Chinese medicine composition of infectious bursal disease, concrete preparation process is: 1. by each taste medicine ultrasonic grinding, crosses 80 mesh sieves, mix homogeneously;
2. the mixed-powder that 1. step obtains is added fermentation medium and compound bacteria bacterium liquid, 37 DEG C of closing anaerobic fermentation 18h, obtain tunning; Described fermentation medium is made up of the component of following mass percent, in Chinese medicine gross mass for radix, and wheat bran 23%, bean cake 3%, ammonium sulfate 2%, magnesium sulfate 0.5%, calcium carbonate 1.5%, water 25%; Compound bacteria bacterium liquid is 1% of Chinese medicine composition gross mass, the preparation method of compound bacteria bacterium liquid: a. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively, by the bacterium colony normal saline eluting that often kind of slant culture produces, add and increase amplification culture in bacterium cultured solution of broth, be cultured to exponential phase 0.8 × 10
8cFU/mL; B. lactobacillus obtained for step a, yeast, streptococcus faecalis and bacillus amplification culture bacterium liquid are mixed to get composite bacteria liquid according to 2:1:1:1 ratio;
3. stabilizing agent is added in the tunning 2. obtained to step, 0-4 DEG C of vacuum drying 13h, described stabilizing agent is preservative sodium benzoate and antioxidant propyl gallate, the addition of sodium benzoate is 0.08% of tunning quality, and the addition of propyl gallate is 0.005% of tunning quality.
Composite fermentation type Chinese medicine composition makes an addition in feedstuff in the 0.5-1% ratio of feeding quality, and mixing, throws something and feeds.
Embodiment 6
Prevent and treat a Composite fermentation type Chinese medicine composition for infectious bursal disease, it is prepared from by each component of following weight portion: Radix Isatidis 32g, Herb Gynostemmae Pentaphylli 35g, Herba Taraxaci 42g, Flos Lonicerae 15g, Folium Artemisiae Argyi 50g, Herba Andrographis 41g, toad clothing 7g, Borneolum Syntheticum 6g, Radix Glycyrrhizae 5g, Radix Rubiae 5g.
The preparation method of compound fermentation type Chinese medicine and usage and dosage are with embodiment 1.
Embodiment 7
Prevent and treat a Composite fermentation type Chinese medicine composition for infectious bursal disease, it is prepared from by each component of following weight portion: Radix Isatidis 35g, Herb Gynostemmae Pentaphylli 32g, Herba Taraxaci 50g, Flos Lonicerae 29g, Folium Artemisiae Argyi 65g, Herba Andrographis 45g, toad clothing 1g, Borneolum Syntheticum 4g, Radix Glycyrrhizae 7g, Radix Rubiae 7g.
The preparation method of compound fermentation type Chinese medicine and usage and dosage are with embodiment 1.
Embodiment 8
Prevent and treat a Composite fermentation type Chinese medicine composition for infectious bursal disease, it is prepared from by each component of following weight portion: Radix Isatidis 37g, Herb Gynostemmae Pentaphylli 28g, Herba Taraxaci 48g, Flos Lonicerae 27g, Folium Artemisiae Argyi 58g, Herba Andrographis 35g, toad clothing 3g, Borneolum Syntheticum 8g, Radix Glycyrrhizae 8g, Radix Rubiae 9g.
The preparation method of compound fermentation type Chinese medicine and usage and dosage are with embodiment 1.
Embodiment 9
Prevent and treat a Composite fermentation type Chinese medicine composition for infectious bursal disease, it is prepared from by each component of following weight portion: Radix Isatidis 38g, Herb Gynostemmae Pentaphylli 26g, Herba Taraxaci 45g, Flos Lonicerae 22g, Folium Artemisiae Argyi 67g, Herba Andrographis 30g, toad clothing 6g, Borneolum Syntheticum 4g, Radix Glycyrrhizae 13g, Radix Rubiae 20g.
The preparation method of compound fermentation type Chinese medicine and usage and dosage are with embodiment 1.
Embodiment 10
Prevent and treat a Composite fermentation type Chinese medicine composition for infectious bursal disease, it is prepared from by each component of following weight portion: Radix Isatidis 40g, Herb Gynostemmae Pentaphylli 25g, Herba Taraxaci 38g, Flos Lonicerae 25g, Folium Artemisiae Argyi 70g, Herba Andrographis 50g, toad clothing 5g, Borneolum Syntheticum 6g, Radix Glycyrrhizae 18g, Radix Rubiae 18g.
The preparation method of compound fermentation type Chinese medicine and usage and dosage are with embodiment 1.
Test example:
Henan certain body raiser 13 Japanese instar chickling, about 1400 chicken morbidities, sick chicken dysentery, arranges shallow white or light green loose stool, and normal containing urate in diarrhoea thing, perianal feather is polluted by excrement or stains earth.Along with the development of the course of disease, drink, loss of appetite, and become thin gradually, fear of cold; cervical region trunk tremor; instability of gait, walking is waved, body temperature normal or at disease body temperature in latter stage lower than normally; down in spirits; sagging catacleisis, feather is matt, fluffy dehydration; Sunken orbital socket, last extreme exhaustion and dead.The chicken dying from infection presents dehydration, chest muscle obfuscation, and thigh and chest muscle often have ecchymosis, point, and in intestinal, mucus increases, kidney enlargement, pale, and lobule canescence, has urate deposition, and enlargement appears in fabricius bursa, is infectious bursal disease infection after diagnosing.
The Composite fermentation type Chinese medicine composition of control infectious bursal disease prepared by application the present invention is treated, and adopt and make an addition in feedstuff in the 0.5-1% ratio of feeding quality, mixing, throws something and feeds, and carries out strict sterilization before and after treatment to hen house and surrounding.Medication after 2 days chicken group sb.'s illness took a favorable turn, medication is after 5 days, and 1365 sick chickens get well, clinical symptom disappearance, and cure rate reaches 97.5%, and cure return visit in latter month, rehabilitation chicken group does not fall ill again.
The general formulation Chinese medicine composition prepared of formula that application the present invention announces is treated, medication after 5 days chicken group sb.'s illness took a favorable turn, medication is after 9 days, 1269 sick chickens get well, clinical symptom disappearance, and cure rate reaches 90.64%, cure return visit in latter month, rehabilitation chicken group does not fall ill again.
Claims (6)
1. prevent and treat a Composite fermentation type Chinese medicine composition for infectious bursal disease, it is characterized in that it is prepared from by each component of following weight portion: Radix Isatidis 25-40, Herb Gynostemmae Pentaphylli 25-40, Herba Taraxaci 30-50, Flos Lonicerae 10-30, Folium Artemisiae Argyi 50-70, Herba Andrographis 30-50, toad clothing 1-8, Borneolum Syntheticum 2-8, Radix Glycyrrhizae 5-18, Radix Rubiae 5-20.
2. a kind of Composite fermentation type Chinese medicine composition preventing and treating infectious bursal disease according to claim 1, is characterized in that it is prepared from by each component of following weight portion: Radix Isatidis 30, Herb Gynostemmae Pentaphylli 30, Herba Taraxaci 40, Flos Lonicerae 20, Folium Artemisiae Argyi 60, Herba Andrographis 40, toad clothing 5, Borneolum Syntheticum 5, Radix Glycyrrhizae 10, Radix Rubiae 10.
3. a kind of preparation method of preventing and treating the Composite fermentation type Chinese medicine composition of infectious bursal disease according to claim 1 or 2, is characterized in that: concrete preparation process is 1. by each taste medicine ultrasonic grinding, crosses 80-100 mesh sieve, mix homogeneously; 2. the mixed-powder that 1. step obtains is added fermentation medium and compound bacteria bacterium liquid, 36-37 DEG C of closing anaerobic fermentation 12-14h, obtains tunning; 3. stabilizing agent is added, 0-4 DEG C of vacuum drying 12-14h in the tunning 2. obtained to step.
4. a kind of preparation method of preventing and treating the Composite fermentation type Chinese medicine composition of infectious bursal disease according to claim 3, it is characterized in that: step 2. middle fermentation medium is made up of the component of following mass percent, in Chinese medicine gross mass for radix, wheat bran 20-30%, bean cake 3-4%, ammonium sulfate 1-2%, magnesium sulfate 0.5-1%, calcium carbonate 1-2%, water 20-30%.
5. a kind of preparation method of preventing and treating the Composite fermentation type Chinese medicine composition of infectious bursal disease according to claim 3, it is characterized in that: step 2. middle compound bacteria bacterium liquid is the 0.5-1.5% of Chinese medicine composition gross mass, the preparation method of compound bacteria bacterium liquid: a. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively, by the bacterium colony normal saline eluting that often kind of slant culture produces, add and increase amplification culture in bacterium cultured solution of broth, be cultured to exponential phase 0.5-1.0 × 10
8cFU/mL; B. the lactobacillus obtained by step a, yeast, streptococcus faecalis and bacillus amplification culture bacterium liquid are according to 2:(1-1.2): (0.8-1): (1-1.2) ratio is mixed to get composite bacteria liquid.
6. a kind of preparation method of preventing and treating the Composite fermentation type Chinese medicine composition of infectious bursal disease according to claim 3, it is characterized in that: step 3. middle stabilizing agent is preservative sodium benzoate and antioxidant propyl gallate, the addition of sodium benzoate is the 0.05-0.1% of step 2. gained tunning quality, and the addition of propyl gallate is the 0.005-0.008% of step 2. gained tunning quality.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873951A (en) * | 2015-06-01 | 2015-09-02 | 河南欧普生物科技有限公司 | Production method for fermented type body-resistance-strengthening detoxifying powder |
| CN104906174A (en) * | 2015-06-23 | 2015-09-16 | 河南牧业经济学院 | Fermented traditional Chinese medicine for preventing and treating infectious bursal disease of chicken and preparation method of fermented traditional Chinese medicine |
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| CN101653471A (en) * | 2009-09-01 | 2010-02-24 | 天津市万格尔生物工程有限公司 | Chinese medicament fumigant for treating chicken bursal vesiculitis and preparation method thereof |
| CN103041120A (en) * | 2011-10-12 | 2013-04-17 | 董根荣 | Pharmaceutical composition for controlling chicken infectious bursal disease and preparation method thereof |
| CN103550189A (en) * | 2013-11-15 | 2014-02-05 | 青岛农业大学 | Chinese herb veterinary micro-capsule preparation and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101653471A (en) * | 2009-09-01 | 2010-02-24 | 天津市万格尔生物工程有限公司 | Chinese medicament fumigant for treating chicken bursal vesiculitis and preparation method thereof |
| CN103041120A (en) * | 2011-10-12 | 2013-04-17 | 董根荣 | Pharmaceutical composition for controlling chicken infectious bursal disease and preparation method thereof |
| CN103550189A (en) * | 2013-11-15 | 2014-02-05 | 青岛农业大学 | Chinese herb veterinary micro-capsule preparation and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873951A (en) * | 2015-06-01 | 2015-09-02 | 河南欧普生物科技有限公司 | Production method for fermented type body-resistance-strengthening detoxifying powder |
| CN104906174A (en) * | 2015-06-23 | 2015-09-16 | 河南牧业经济学院 | Fermented traditional Chinese medicine for preventing and treating infectious bursal disease of chicken and preparation method of fermented traditional Chinese medicine |
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Application publication date: 20150429 |