CN104478607A - 一种百里香酚杀菌剂及其制备方法 - Google Patents
一种百里香酚杀菌剂及其制备方法 Download PDFInfo
- Publication number
- CN104478607A CN104478607A CN201410792481.4A CN201410792481A CN104478607A CN 104478607 A CN104478607 A CN 104478607A CN 201410792481 A CN201410792481 A CN 201410792481A CN 104478607 A CN104478607 A CN 104478607A
- Authority
- CN
- China
- Prior art keywords
- thymol
- weight percentage
- sodium
- isopentennyladenine
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 title claims abstract description 352
- 239000005844 Thymol Substances 0.000 title claims abstract description 178
- 229960000790 thymol Drugs 0.000 title claims abstract description 178
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 44
- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 239000003899 bactericide agent Substances 0.000 title abstract description 10
- 150000001413 amino acids Chemical class 0.000 claims abstract description 61
- 201000010099 disease Diseases 0.000 claims abstract description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 12
- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims abstract description 7
- 240000003768 Solanum lycopersicum Species 0.000 claims abstract description 7
- 241000221785 Erysiphales Species 0.000 claims abstract description 6
- 244000241235 Citrullus lanatus Species 0.000 claims abstract description 5
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 claims abstract description 5
- 244000061458 Solanum melongena Species 0.000 claims abstract description 5
- 235000002597 Solanum melongena Nutrition 0.000 claims abstract description 5
- 241000082085 Verticillium <Phyllachorales> Species 0.000 claims abstract description 5
- 235000002566 Capsicum Nutrition 0.000 claims abstract description 3
- 230000001154 acute effect Effects 0.000 claims abstract description 3
- -1 ange Species 0.000 claims abstract description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 53
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 53
- 239000000203 mixture Substances 0.000 claims description 49
- 239000003995 emulsifying agent Substances 0.000 claims description 48
- 210000000481 breast Anatomy 0.000 claims description 44
- 230000001954 sterilising effect Effects 0.000 claims description 43
- 238000004659 sterilization and disinfection Methods 0.000 claims description 43
- AEIJVYPRKAWFPN-UHFFFAOYSA-N 2-(diethylamino)ethyl hexanoate Chemical compound CCCCCC(=O)OCCN(CC)CC AEIJVYPRKAWFPN-UHFFFAOYSA-N 0.000 claims description 35
- 150000001412 amines Chemical class 0.000 claims description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 34
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethyl sulfoxide Natural products CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 34
- 239000006185 dispersion Substances 0.000 claims description 29
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 27
- 238000003756 stirring Methods 0.000 claims description 25
- 239000005995 Aluminium silicate Substances 0.000 claims description 23
- 235000012211 aluminium silicate Nutrition 0.000 claims description 23
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical group O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 23
- 239000002904 solvent Substances 0.000 claims description 23
- 239000000839 emulsion Substances 0.000 claims description 22
- 229920005552 sodium lignosulfonate Polymers 0.000 claims description 21
- 239000003814 drug Substances 0.000 claims description 18
- 239000000080 wetting agent Substances 0.000 claims description 18
- 235000010297 nisin Nutrition 0.000 claims description 17
- NVNLLIYOARQCIX-MSHCCFNRSA-N Nisin Chemical compound N1C(=O)[C@@H](CC(C)C)NC(=O)C(=C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](NC(=O)C(=C/C)/NC(=O)[C@H](N)[C@H](C)CC)CSC[C@@H]1C(=O)N[C@@H]1C(=O)N2CCC[C@@H]2C(=O)NCC(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(NCC(=O)N[C@H](C)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)NCC(=O)N[C@H](CS[C@@H]2C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CCSC)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(N[C@H](C)C(=O)N[C@@H]3C(=O)N[C@@H](C(N[C@H](CC=4NC=NC=4)C(=O)N[C@H](CS[C@@H]3C)C(=O)N[C@H](CO)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](CC=3NC=NC=3)C(=O)N[C@H](C(C)C)C(=O)NC(=C)C(=O)N[C@H](CCCCN)C(O)=O)=O)CS[C@@H]2C)=O)=O)CS[C@@H]1C NVNLLIYOARQCIX-MSHCCFNRSA-N 0.000 claims description 14
- 108010053775 Nisin Proteins 0.000 claims description 14
- 239000004309 nisin Substances 0.000 claims description 14
- 239000004530 micro-emulsion Substances 0.000 claims description 13
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 12
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 12
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 12
- 239000011575 calcium Substances 0.000 claims description 12
- 229910052791 calcium Inorganic materials 0.000 claims description 12
- 239000006229 carbon black Substances 0.000 claims description 12
- 239000004495 emulsifiable concentrate Substances 0.000 claims description 12
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 12
- 235000019832 sodium triphosphate Nutrition 0.000 claims description 12
- 239000003921 oil Substances 0.000 claims description 11
- 235000013311 vegetables Nutrition 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 10
- 239000000725 suspension Substances 0.000 claims description 10
- 239000004563 wettable powder Substances 0.000 claims description 10
- 239000013530 defoamer Substances 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 9
- 239000012466 permeate Substances 0.000 claims description 9
- 230000008719 thickening Effects 0.000 claims description 9
- 239000004562 water dispersible granule Substances 0.000 claims description 9
- LVDKZNITIUWNER-UHFFFAOYSA-N Bronopol Chemical compound OCC(Br)(CO)[N+]([O-])=O LVDKZNITIUWNER-UHFFFAOYSA-N 0.000 claims description 8
- 239000008367 deionised water Substances 0.000 claims description 8
- 229910021641 deionized water Inorganic materials 0.000 claims description 8
- 239000012153 distilled water Substances 0.000 claims description 8
- 239000008399 tap water Substances 0.000 claims description 8
- 235000020679 tap water Nutrition 0.000 claims description 8
- 235000004936 Bromus mango Nutrition 0.000 claims description 7
- 240000007228 Mangifera indica Species 0.000 claims description 7
- 235000014826 Mangifera indica Nutrition 0.000 claims description 7
- 235000009184 Spondias indica Nutrition 0.000 claims description 7
- 229920002472 Starch Polymers 0.000 claims description 7
- 238000009775 high-speed stirring Methods 0.000 claims description 7
- 239000002480 mineral oil Substances 0.000 claims description 7
- 235000010446 mineral oil Nutrition 0.000 claims description 7
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 7
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 7
- 229920001289 polyvinyl ether Polymers 0.000 claims description 7
- 239000008107 starch Substances 0.000 claims description 7
- 229940032147 starch Drugs 0.000 claims description 7
- 235000019698 starch Nutrition 0.000 claims description 7
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 6
- BCZXFFBUYPCTSJ-UHFFFAOYSA-L Calcium propionate Chemical compound [Ca+2].CCC([O-])=O.CCC([O-])=O BCZXFFBUYPCTSJ-UHFFFAOYSA-L 0.000 claims description 6
- 101710194948 Protein phosphatase PhpP Proteins 0.000 claims description 6
- 239000004288 Sodium dehydroacetate Substances 0.000 claims description 6
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 claims description 6
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 6
- 239000004330 calcium propionate Substances 0.000 claims description 6
- 235000010331 calcium propionate Nutrition 0.000 claims description 6
- OPGYRRGJRBEUFK-UHFFFAOYSA-L disodium;diacetate Chemical compound [Na+].[Na+].CC([O-])=O.CC([O-])=O OPGYRRGJRBEUFK-UHFFFAOYSA-L 0.000 claims description 6
- 229920005610 lignin Polymers 0.000 claims description 6
- HWGNBUXHKFFFIH-UHFFFAOYSA-I pentasodium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O HWGNBUXHKFFFIH-UHFFFAOYSA-I 0.000 claims description 6
- 150000003014 phosphoric acid esters Chemical class 0.000 claims description 6
- 239000004302 potassium sorbate Substances 0.000 claims description 6
- 235000010241 potassium sorbate Nutrition 0.000 claims description 6
- 229940069338 potassium sorbate Drugs 0.000 claims description 6
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 6
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 6
- 229960003415 propylparaben Drugs 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- 239000001632 sodium acetate Substances 0.000 claims description 6
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 6
- 239000004299 sodium benzoate Substances 0.000 claims description 6
- 235000010234 sodium benzoate Nutrition 0.000 claims description 6
- 229960003885 sodium benzoate Drugs 0.000 claims description 6
- 235000019259 sodium dehydroacetate Nutrition 0.000 claims description 6
- 229940079839 sodium dehydroacetate Drugs 0.000 claims description 6
- 235000017454 sodium diacetate Nutrition 0.000 claims description 6
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 claims description 6
- NGSFWBMYFKHRBD-UHFFFAOYSA-N sodium;2-hydroxypropanoic acid Chemical compound [Na+].CC(O)C(O)=O NGSFWBMYFKHRBD-UHFFFAOYSA-N 0.000 claims description 6
- 125000003639 thymyl group Chemical class C1(=CC(C)=CC=C1C(C)C)* 0.000 claims description 6
- UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 claims description 6
- CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 claims description 4
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims description 4
- 241000233622 Phytophthora infestans Species 0.000 claims description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 4
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 4
- 240000002657 Thymus vulgaris Species 0.000 claims description 4
- 235000007303 Thymus vulgaris Nutrition 0.000 claims description 4
- 241001272684 Xanthomonas campestris pv. oryzae Species 0.000 claims description 4
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 claims description 4
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 4
- KZOJQMWTKJDSQJ-UHFFFAOYSA-M sodium;2,3-dibutylnaphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CCCC)C(CCCC)=CC2=C1 KZOJQMWTKJDSQJ-UHFFFAOYSA-M 0.000 claims description 4
- 239000001585 thymus vulgaris Substances 0.000 claims description 4
- 239000007789 gas Substances 0.000 claims description 3
- 238000005469 granulation Methods 0.000 claims description 3
- 230000003179 granulation Effects 0.000 claims description 3
- 239000004576 sand Substances 0.000 claims description 3
- YSUQLAYJZDEMOT-UHFFFAOYSA-N 2-(butoxymethyl)oxirane Chemical compound CCCCOCC1CO1 YSUQLAYJZDEMOT-UHFFFAOYSA-N 0.000 claims description 2
- CUFXMPWHOWYNSO-UHFFFAOYSA-N 2-[(4-methylphenoxy)methyl]oxirane Chemical compound C1=CC(C)=CC=C1OCC1OC1 CUFXMPWHOWYNSO-UHFFFAOYSA-N 0.000 claims description 2
- AOBIOSPNXBMOAT-UHFFFAOYSA-N 2-[2-(oxiran-2-ylmethoxy)ethoxymethyl]oxirane Chemical compound C1OC1COCCOCC1CO1 AOBIOSPNXBMOAT-UHFFFAOYSA-N 0.000 claims description 2
- YHQXBTXEYZIYOV-UHFFFAOYSA-N 3-methylbut-1-ene Chemical compound CC(C)C=C YHQXBTXEYZIYOV-UHFFFAOYSA-N 0.000 claims description 2
- RNMDNPCBIKJCQP-UHFFFAOYSA-N 5-nonyl-7-oxabicyclo[4.1.0]hepta-1,3,5-trien-2-ol Chemical compound C(CCCCCCCC)C1=C2C(=C(C=C1)O)O2 RNMDNPCBIKJCQP-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 229920001817 Agar Polymers 0.000 claims description 2
- 241000193738 Bacillus anthracis Species 0.000 claims description 2
- 240000008574 Capsicum frutescens Species 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- 241000207199 Citrus Species 0.000 claims description 2
- 229920002785 Croscarmellose sodium Polymers 0.000 claims description 2
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical group ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- FQYUMYWMJTYZTK-UHFFFAOYSA-N Phenyl glycidyl ether Chemical compound C1OC1COC1=CC=CC=C1 FQYUMYWMJTYZTK-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 239000008272 agar Substances 0.000 claims description 2
- 235000010419 agar Nutrition 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- VEQOALNAAJBPNY-UHFFFAOYSA-N antipyrine Chemical compound CN1C(C)=CC(=O)N1C1=CC=CC=C1 VEQOALNAAJBPNY-UHFFFAOYSA-N 0.000 claims description 2
- 239000001390 capsicum minimum Substances 0.000 claims description 2
- 229960001631 carbomer Drugs 0.000 claims description 2
- 229920006184 cellulose methylcellulose Polymers 0.000 claims description 2
- 235000020971 citrus fruits Nutrition 0.000 claims description 2
- 229960001681 croscarmellose sodium Drugs 0.000 claims description 2
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 210000004907 gland Anatomy 0.000 claims description 2
- 239000000017 hydrogel Substances 0.000 claims description 2
- 230000002045 lasting effect Effects 0.000 claims description 2
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 235000010981 methylcellulose Nutrition 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000001814 pectin Substances 0.000 claims description 2
- 229920001277 pectin Polymers 0.000 claims description 2
- 235000010987 pectin Nutrition 0.000 claims description 2
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 239000000377 silicon dioxide Substances 0.000 claims description 2
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 2
- 229940079832 sodium starch glycolate Drugs 0.000 claims description 2
- 229920003109 sodium starch glycolate Polymers 0.000 claims description 2
- 239000008109 sodium starch glycolate Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 33
- 230000012010 growth Effects 0.000 abstract description 5
- 239000002552 dosage form Substances 0.000 abstract description 3
- 230000008635 plant growth Effects 0.000 abstract description 3
- 231100000419 toxicity Toxicity 0.000 abstract description 3
- 230000001988 toxicity Effects 0.000 abstract description 3
- 235000016709 nutrition Nutrition 0.000 abstract description 2
- 230000001863 plant nutrition Effects 0.000 abstract description 2
- 230000001737 promoting effect Effects 0.000 abstract description 2
- 241000123650 Botrytis cinerea Species 0.000 abstract 1
- 239000006002 Pepper Substances 0.000 abstract 1
- 241000233614 Phytophthora Species 0.000 abstract 1
- 235000016761 Piper aduncum Nutrition 0.000 abstract 1
- 235000017804 Piper guineense Nutrition 0.000 abstract 1
- 244000203593 Piper nigrum Species 0.000 abstract 1
- 235000008184 Piper nigrum Nutrition 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000005923 long-lasting effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 description 21
- 239000003153 chemical reaction reagent Substances 0.000 description 15
- 238000012360 testing method Methods 0.000 description 7
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- 239000000376 reactant Substances 0.000 description 6
- UQKPSPCYFJJPTO-UHFFFAOYSA-N 5-methyl-2-propan-2-ylphenol;potassium Chemical compound [K].CC(C)C1=CC=C(C)C=C1O UQKPSPCYFJJPTO-UHFFFAOYSA-N 0.000 description 4
- 150000003601 thymols Chemical class 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 240000008067 Cucumis sativus Species 0.000 description 3
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000001850 reproductive effect Effects 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- HYVABZIGRDEKCD-UHFFFAOYSA-N N(6)-dimethylallyladenine Chemical compound CC(C)=CCNC1=NC=NC2=C1N=CN2 HYVABZIGRDEKCD-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 230000002070 germicidal effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- XVRFLAKLFMLOPO-UHFFFAOYSA-N 3-hydroxy-5-methyl-1h-pyrimidine-2,4-dione Chemical compound CC1=CNC(=O)N(O)C1=O XVRFLAKLFMLOPO-UHFFFAOYSA-N 0.000 description 1
- IOAISUCAQCEHTA-UHFFFAOYSA-N 5-methyl-2-propan-2-ylphenol Chemical compound CC(C)C1=CC=C(C)C=C1O.CC(C)C1=CC=C(C)C=C1O IOAISUCAQCEHTA-UHFFFAOYSA-N 0.000 description 1
- INCRRYKLCCVPJD-UHFFFAOYSA-N 6-hydroxy-5-methyl-1h-pyrimidine-2,4-dione Chemical compound CC1=C(O)NC(=O)NC1=O INCRRYKLCCVPJD-UHFFFAOYSA-N 0.000 description 1
- 241000050051 Chelone glabra Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 241000233679 Peronosporaceae Species 0.000 description 1
- NRTOMJZYCJJWKI-UHFFFAOYSA-N Titanium nitride Chemical compound [Ti]#N NRTOMJZYCJJWKI-UHFFFAOYSA-N 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000001857 anti-mycotic effect Effects 0.000 description 1
- 239000002543 antimycotic Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 229930007927 cymene Natural products 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 230000004992 fission Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000028245 fruit abscission Effects 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- HFPZCAJZSCWRBC-UHFFFAOYSA-N p-cymene Chemical compound CC(C)C1=CC=C(C)C=C1 HFPZCAJZSCWRBC-UHFFFAOYSA-N 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000004476 plant protection product Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 230000002786 root growth Effects 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- PRZSXZWFJHEZBJ-UHFFFAOYSA-N thymol blue Chemical compound C1=C(O)C(C(C)C)=CC(C2(C3=CC=CC=C3S(=O)(=O)O2)C=2C(=CC(O)=C(C(C)C)C=2)C)=C1C PRZSXZWFJHEZBJ-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
供试药剂 | 病害 | 稀释倍数 | 3d防治效果 | 7d防治效果 | 14d防治效果 |
百里香酚杀菌水剂 | 芒果炭疽病 | 1000X | 91.36% | 93.26% | 95.55% |
含18%百里香酚溶液 | 芒果炭疽病 | 1000X | 60.52% | 65.30% | 67.25% |
供试药剂 | 病害 | 稀释倍数 | 3d防治效果 | 7d防治效果 | 14d防治效果 |
百里香酚杀菌微乳剂 | 茄子黄萎病 | 1000X | 90.52% | 93.26% | 96.55% |
含10%百里香酚溶液 | 茄子黄萎病 | 1000X | 50.32% | 55.51% | 57.56% |
供试药剂 | 病害 | 稀释倍数 | 3d防治效果 | 7d防治效果 | 14d防治效果 |
百里香酚杀菌水乳剂 | 番茄灰霉病 | 1000X | 89.64% | 93.26% | 95.36% |
含10%百里香酚溶液 | 番茄灰霉病 | 1000X | 50.02% | 53.26% | 57.22% |
供试药剂 | 病害 | 稀释倍数 | 3d防治效果 | 7d防治效果 | 14d防治效果 |
里香酚杀菌可湿性粉剂 | 西瓜白粉病 | 1000X | 89.53% | 93.17% | 95.31% |
含40%百里香酚溶液 | 西瓜白粉病 | 1000X | 70.62% | 73.27% | 75.12% |
供试药剂 | 病害 | 稀释倍数 | 3d防治效果 | 7d防治效果 | 14d防治效果 |
百里香酚杀菌悬乳剂 | 西红柿晚疫病 | 1000X | 88.30% | 93.25% | 94.21% |
含10%百里香酚溶液 | 西红柿晚疫病病菌 | 1000X | 50.02% | 54.24% | 60.21% |
供试药剂 | 病害 | 稀释倍数 | 3d防治效果 | 7d防治效果 | 14d防治效果 |
百里香酚杀菌乳油剂 | 芒果炭疽病 | 1000X | 83.25% | 87.11% | 91.84% |
含25%百里香酚溶液 | 芒果炭疽病 | 1000X | 62.24% | 66.29% | 70.23% |
供试药剂 | 病害 | 稀释倍数 | 3d防治效果 | 7d防治效果 | 14d防治效果 |
百里香酚杀菌乳油剂 | 水稻白叶枯病 | 1000X | 80.45% | 85.13% | 92.79% |
含20%百里香酚溶液 | 水稻白叶枯病 | 1000X | 60.12% | 64.36% | 72.25% |
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410792481.4A CN104478607B (zh) | 2014-12-19 | 2014-12-19 | 一种百里香酚杀菌剂及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410792481.4A CN104478607B (zh) | 2014-12-19 | 2014-12-19 | 一种百里香酚杀菌剂及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104478607A true CN104478607A (zh) | 2015-04-01 |
CN104478607B CN104478607B (zh) | 2017-06-16 |
Family
ID=52753247
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410792481.4A Active CN104478607B (zh) | 2014-12-19 | 2014-12-19 | 一种百里香酚杀菌剂及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104478607B (zh) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105123717A (zh) * | 2015-10-26 | 2015-12-09 | 唐睿 | 一种具有增效功能的植物生长调节组合物制剂 |
CN105123803A (zh) * | 2015-10-26 | 2015-12-09 | 唐睿 | 一种含有百里香酚和春雷霉素的植物源杀菌剂 |
CN105123700A (zh) * | 2015-10-26 | 2015-12-09 | 唐睿 | 一种含有百里香酚与槟榔碱的杀虫杀菌剂及其制备方法 |
CN105152771A (zh) * | 2015-08-25 | 2015-12-16 | 陕西澄城国绿果农实业有限公司 | 一种高营养苹果培养液、制备方法及其使用方法 |
CN105638648A (zh) * | 2016-01-08 | 2016-06-08 | 广州市生物防治站 | 一种百里香酚-甲氨基阿维菌素苯甲酸盐水乳剂 |
CN107237215A (zh) * | 2017-07-28 | 2017-10-10 | 临朐玉龙造纸有限公司 | 保鲜防油食品包装纸及其制作方法 |
CN110250215A (zh) * | 2019-08-05 | 2019-09-20 | 云南中医药大学 | 佩兰挥发油的新用途 |
CN112263571A (zh) * | 2020-10-27 | 2021-01-26 | 青岛大学附属医院 | 百里香酚在制备用于治疗真菌性角膜炎的药物中的应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090130159A1 (en) * | 2007-11-16 | 2009-05-21 | Fujifilm Corporation | Water-dispersible nanoparticle containing microbicide |
CN102014616A (zh) * | 2008-03-19 | 2011-04-13 | 蒂拉德克公司 | 使用天然害虫控制剂掺合物的害虫控制 |
-
2014
- 2014-12-19 CN CN201410792481.4A patent/CN104478607B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090130159A1 (en) * | 2007-11-16 | 2009-05-21 | Fujifilm Corporation | Water-dispersible nanoparticle containing microbicide |
CN102014616A (zh) * | 2008-03-19 | 2011-04-13 | 蒂拉德克公司 | 使用天然害虫控制剂掺合物的害虫控制 |
Non-Patent Citations (2)
Title |
---|
张静等: "百里香酚抑菌活性初探", 《中国农学通报》 * |
苏梦云等: "TDS生长调节剂提高板栗结果率技术的研究", 《林业科学研究》 * |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105152771A (zh) * | 2015-08-25 | 2015-12-16 | 陕西澄城国绿果农实业有限公司 | 一种高营养苹果培养液、制备方法及其使用方法 |
CN105123717A (zh) * | 2015-10-26 | 2015-12-09 | 唐睿 | 一种具有增效功能的植物生长调节组合物制剂 |
CN105123803A (zh) * | 2015-10-26 | 2015-12-09 | 唐睿 | 一种含有百里香酚和春雷霉素的植物源杀菌剂 |
CN105123700A (zh) * | 2015-10-26 | 2015-12-09 | 唐睿 | 一种含有百里香酚与槟榔碱的杀虫杀菌剂及其制备方法 |
CN105123700B (zh) * | 2015-10-26 | 2017-06-16 | 海南博士威农用化学有限公司 | 一种含有百里香酚与槟榔碱的杀虫杀菌剂及其制备方法 |
CN105638648A (zh) * | 2016-01-08 | 2016-06-08 | 广州市生物防治站 | 一种百里香酚-甲氨基阿维菌素苯甲酸盐水乳剂 |
CN105638648B (zh) * | 2016-01-08 | 2018-05-18 | 广州市生物防治站 | 一种百里香酚-甲氨基阿维菌素苯甲酸盐水乳剂 |
CN107237215A (zh) * | 2017-07-28 | 2017-10-10 | 临朐玉龙造纸有限公司 | 保鲜防油食品包装纸及其制作方法 |
CN107237215B (zh) * | 2017-07-28 | 2019-01-22 | 临朐玉龙造纸有限公司 | 保鲜防油食品包装纸及其制作方法 |
CN110250215A (zh) * | 2019-08-05 | 2019-09-20 | 云南中医药大学 | 佩兰挥发油的新用途 |
CN112263571A (zh) * | 2020-10-27 | 2021-01-26 | 青岛大学附属医院 | 百里香酚在制备用于治疗真菌性角膜炎的药物中的应用 |
Also Published As
Publication number | Publication date |
---|---|
CN104478607B (zh) | 2017-06-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104478607A (zh) | 一种百里香酚杀菌剂及其制备方法 | |
CN102106349B (zh) | 含戊唑醇与嘧啶类化合物的杀真菌组合物 | |
CN102511513A (zh) | 一种复方植物杀菌剂及其制备和应用 | |
CN103155936A (zh) | 一种含有申嗪霉素的植物病害防治组合物 | |
CN105248424A (zh) | 杀菌组合物及其应用 | |
CN104521989A (zh) | 含甲磺酰菌唑和酰胺类杀菌剂的复配组合物及制剂 | |
CN105794857A (zh) | 一种木霉菌可湿性粉剂的制备方法 | |
CN102823602B (zh) | 一种含有噻霉酮和氟环唑的杀菌组合物 | |
CN105340911B (zh) | 一种农药组合物及其制备方法与应用 | |
CN101911940A (zh) | 一种由嘧菌酯、苯醚甲环唑与环唑醇复配的杀菌剂及其制备方法 | |
CN103004823A (zh) | 一种含有吡唑醚菌酯和溴菌腈的复配杀菌组合物 | |
CN101263821B (zh) | 一种杀菌剂组合物 | |
CN104926725B (zh) | 一种萘二甲酰亚胺芳基脲类化合物及其用途 | |
CN104522035B (zh) | 一种含甲磺酰菌唑和敌磺钠的复配组合物及制剂 | |
CN103907648B (zh) | 一种防治植物霜霉病的复方植物杀菌剂的制备和应用 | |
CN102701841B (zh) | 生物杀菌剂白屈菜红碱水乳剂及其制备方法 | |
CN102308835B (zh) | 一种含有硫酸链霉素和喹啉铜的农药组合物 | |
CN104542611A (zh) | 一种含有双炔酰菌胺的杀菌组合物 | |
CN101564041B (zh) | 一种咪鲜胺和嘧霉胺复配的杀菌组合物 | |
CN102037961B (zh) | 一种含酚菌酮与稻瘟酰胺的杀菌组合物 | |
CN104542695A (zh) | 一种含甲磺酰菌唑和毒氟磷的复配组合物及制剂 | |
CN101627770A (zh) | 杀菌组合物 | |
CN104488898B (zh) | 含甲磺酰菌唑和辛菌胺醋酸盐的复配组合物及杀菌剂 | |
CN103875657A (zh) | 一种含纳他霉素的抗紫外农用水分散粒剂及其制备方法 | |
CN104488909A (zh) | 一种含甲磺酰菌唑和嘧菌酯的复配组合物及制剂 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20160928 Address after: 571924 the development of Hainan County of Chengmai Province City District Industrial Avenue Meilanglu east of Hainan boshiway Agricultural Chemical Co Ltd Applicant after: Boshiwei Agricultural Chemical Co., Ltd., Hainan Province Address before: 571924 Hainan province Chengmai County Old Town Economic Development Zone Industrial Avenue Meilanglu east of Hainan boshiway Agricultural Chemical Co Ltd Applicant before: Tang Rui |
|
GR01 | Patent grant | ||
CP03 | Change of name, title or address |
Address after: 570100 east of meilang Road, Industrial Avenue, Laocheng Development Zone, Chengmai County, Hainan Province Patentee after: Hainan Bowei Biotechnology Co.,Ltd. Address before: 571924 county level administrative unit directly under the central government of Hainan Province Hainan boshwei agrochemical Co., Ltd., east of meilang Road, Industrial Avenue, Laocheng Development Zone, Chengmai County, Hainan Province Patentee before: HAINAN BOSSWELL AGRICHEMICAL CO.,LTD. |
|
CP03 | Change of name, title or address |