CN104451927A - Traditional Chinese medicine insect-expelling additive and application thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine insect-expelling additive. The additive is characterized by being prepared from the following medicinal raw materials in parts by weight: 10-20 parts of rhizoma atractylodis, 10-20 parts of peppermint, 10-20 parts of shinyleaf pricklyash root, 10-20 parts of sophora flavescens, 10-20 parts of senecio scandens, 10-20 parts of rhizoma kaempferiae, 10-20 parts of acorus calamus, 10-20 parts of folium artemisiae argyi, 10-20 parts of borneol, 10-20 parts of flos magnoliae, 10-20 parts of asarum, 10-20 parts of clove, 10-20 parts of saposhnicovia divaricata, 10-20 parts of cassia twig, 10-20 parts of cinnamon, 10-20 parts of rhizoma cyperi, 10-20 parts of bletilla striata, 10-20 parts of fortune eupatorium herb and 10-20 parts of geranium. The additive is prepared from multiple natural herb extracted ingredients, is natural and mild, can be used for preventing mosquito bite and quickly relieving discomfort after mosquito bite, is pure and mild, is non-irritative and can be used for bringing safe care to adult skins, and keeping people away from mosquito intrusion in summer. The fabric of underware containing the additive is natural, mild, safe, non-greasy, fitting and comfortable.

Description

A kind of Chinese medicine expelling parasite additive and application thereof

                                  

Technical field

The present invention relates to the material containing deriving from plant, animal or mineral component, particularly one a kind of Chinese medicine expelling parasite additive and application thereof.

Background technology

Bite by mosquitos can play bag, this mainly the saliva of skin to insect have allergic reaction, some is all moved back to go down by a wheat harvesting period red packet after bite by mosquitos, and this is more serious, but what large problem bite by mosquitos is not for most people.For bite by mosquitos, present various folk prescription and medicine very many, folk prescription is not necessarily all effective to everyone, such as etc., so, blindly how do not hear of effect.But, common cooling ointment, essential wind oil one class have alcoholic content, so the people of skin sensitivity still as far as possible less use, as the medicine of steroids, antipruritic effect can be clearly.

The dermatitis that bite by mosquitos causes in insect dermatitis is modal.Mosquito stabs skin by its mouthpart, and its saliva or venom invade skin, and owing to containing plurality of antigens composition in the saliva of mosquito or the leachate of poison gland, these antigens can produce allergic reaction with antibody and cause inflammation after entering human body skin.Time serious, indivedual infant local produces the severe reaction such as bleb, hemorrhagic necrosis, is dermatology common disease disease in summer.

Bite by mosquitos is the maximum killer of sleep in summer, especially concerning infant, because its skin is tender and lovely, is easy to by red and swollen after bite by mosquitos, thus causes skin infection.Summer, people came mosquito-expelling and antipruritic, deodorization and sterilization with floral water, if but improper use not only can endanger healthy, and serious also can be fatal.Wherein mainly contain and much use mistaken ideas.One, excessive use is in order to avoid bite by mosquitos, and often a lot of floral water spreads upon each position of whole body.But do like this, somebody there will be health and to itch, emit the symptom of cold sweat, so smear floral water to want appropriate, avoid health to occur bad reaction.Two, use floral water to contain a kind of composition being " Yi Moning " after suffering from dermatitis, it can make mosquito lose the consciousness bitten people.If smear floral water after trouble dermatitis, not only can not treat dermatitis, " Yi Moning " composition also can cause skin to occur allergic reaction, increases the weight of dermatitis symptom.The patient of trouble dermatitis can be dripped 4-5 and be dripped floral water on electric mat, can avoid again allergic by mosquito repellent.Three, be coated with to enter immediately after floral water kitchen " igniting " cook a lot of people all have ignored floral water use after points for attention: burning things which may cause a fire disaster please be avoid and use and store.This is because containing the alcohol of 75% and the perfume ingredient of 5% in floral water, once will light near burning things which may cause a fire disaster.So do not use fire or close burning things which may cause a fire disaster immediately after having smeared floral water, such as: the kitchen range etc. of the naked light that kindles mosquito repellent incense, lights a cigarette, uses.Four, floral water should spread upon the arms and legs portion that mosquito often bites in right amount; The people of skin sensitivity, can drop in floral water on electric mat, or cooling ointment uncap is placed on bedside, can avoid again allergic by mosquito repellent like this; When using floral water to child, 4-5 be diluted doubly, in order to avoid stimulate the skin that child is tender and lovely.

No matter be electric mat or Electric liquid mosquito-repellent incense, the mosquito repellent principle all containing harmful organic compound electric mosquito repellent sucks in anti-mosquito incense sheet by Dalmatian chrysanthemum etc., evaporates after heating, if drip upper several essential wind oil better effects if.Electric liquid mosquito-repellent incense utilizes hair suction pipe principle, and continuous heating release insecticide substance, it is the most convenient to use.By using calculating in eight hours every day, one bottle of mosquito-repellent incense liquid can use 30 days continuously, eliminates the trouble changing electric mat every day.As used in closed room, bad reaction may be produced.Therefore, use during electric mosquito repellent and should maintain the circulation of air.The optimal use time of electric mosquito repellent be before sleeping half an hour.

Now, increasing the weight of of environmental pollution, microorganism is more and more serious on the impact of health, and the microorganism in the Nature is ubiquitous, all-pervasive.Some harmful insects, with the sweat on dress ornament next to the skin, blood, phat fat, scurf etc. for nutrition, in body temperature and moistening environment, breeding rapidly, produces bad compound, volatilizes niff, harmful, induce an illness.These factors make people more and more higher for the requirement of functions of textile fabrics, wish that it can possess several functions simultaneously, as while meeting expelling parasite also can hair tonic anion to improve ambient air quality.

String is a kind of natural polymer subbundle, and its biological structure is made up of countless cellular, wherein contains cellulose, hemicellulose and lignin in cell wall substance.Therefore, string has obvious biological nature, and it is often subject to infringement that is biological and microorganism.Especially with the sponge that string (comprising non-wood and the part secondary stock such as the natural wooden fiber such as timber, bamboo wood and cotton, fiber crops, agricultural crop straw) is prepared from for main raw material, when being applied to the fields such as buffering package, building, insulation and sound insulation, require that it has certain durability.

In recent years, the market demand of viscose is the trend of sustainable growth, cotton, short rayon fiber, terylene short fiber are domestic three large main cotton spinning raw materials, particularly cotton and short rayon fiber, owing to belonging to cellulose fibre together, physical property and wearability have great similitude, and both have mutually substituting, therefore viscose is widely used.Viscose is regenerated celulose fibre, sucting wet air permeability is good, there are good degradability and recoverable, have the advantages that a lot of chemical fibre does not have, can by changing spinning solution component and production technology, modification is carried out to common viscose fiber, increases that it is functional, as antibiotic property, hair tonic anion, insect-repellent etc.

Obtain the viscose with function for expelling pests, just need to add pest repellant in rayon spinning liquid, both co-blended spinnings become Multifunctional adhesive fiber.Coexist for making functional additive and play a role, the selection of additive is very important, it must meet to coexist does not affect its function, in water, in alkali and acid, solubility is extremely low, strong acid, alkali, oxidant are chemically stablized with hot property, spinning process, fibre property is had no adverse effects, there is spinnability, medium can transfer to the surface of fiber from fibrous inside, toxicity and ecological in performance can accept.The valuable character of fiber must be prevented to be subject to too much impact, overall balance should to be tried to achieve in conflicting effect, make fibrous material obtain higher use value and purposes widely.

The present invention have selected the functional additive of natural traditional Chinese medicine plant extracts as Multifunctional adhesive fiber to develop Multifunctional adhesive fiber from numerous pest repellants.

Vast territory and abundant resources in China, abounds with various natural Chinese medicinal herb.Chinese herbal medicine is traditional culture marrow.Traditional Chinese medicine theory is combined with modern science and technology, by various modern techniques such as refinement, extractions, Chinese medicinal herb essence is used for mosquito repellent product series, spy have developed herbal type high-quality and drives kill mosquito product, adopts multiple extracted form natural plant composition, naturally gentle, the discomfort after bite by mosquitos can be alleviated rapidly, the pure gentleness of product, non-stimulated, give the care that the skin of adult is safer.The skin that bite by mosquitos brings to being grown up is uncomfortable, and order adult skin is refrigerant pleasant, invades and harasses away from mosquito in summer.Natural gentleness, safety, non-greasy.

Summary of the invention

Technical problem to be solved by this invention is, the present invention adopts multiple extracted form natural plant composition, naturally gentle, bite by mosquitos can be stoped, also can alleviate rapidly the discomfort after bite by mosquitos, the pure gentleness of product, non-stimulated, give skin and the safer care of adult of adult.People is allowed to invade and harass away from mosquito in summer.The natural gentleness of underwear fabric of the present invention, safety, non-greasy, snug fit.

For solving these technical problems, the invention provides a kind of Chinese medicine expelling parasite additive, described in it, the parts by weight of the various bulk drug of Chinese medicine expelling parasite additive are: rhizoma atractylodis 10 ~ 20 parts, peppermint 10 ~ 20 parts, Radix zanthoxyli 10 ~ 20 parts, kuh-seng 10 ~ 20 parts, climbing groundsel 10 ~ 20 parts, kaempferia galamga 10 ~ 20 parts, calamus 10 ~ 20 parts, tarragon 10 ~ 20 parts, borneol 10 ~ 20 parts, the flower bud of lily magnolia 10 ~ 20 parts, the root of Chinese wild ginger 10 ~ 20 parts, cloves 10 ~ 20 parts, windproof 10 ~ 20 parts, cassia twig 10 ~ 20 parts, Chinese cassia tree 10 ~ 20 parts, rhizoma cyperi 10 ~ 20 parts, the bletilla striata 10 ~ 20 parts, eupatorium 10 ~ 20 parts, pelargonium 10 ~ 20 parts.

Described Chinese medicine expelling parasite additive, described in it, the parts by weight of the various bulk drug of Chinese medicine expelling parasite additive are: rhizoma atractylodis 10 ~ 15 parts, peppermint 10 ~ 15 parts, Radix zanthoxyli 10 ~ 15 parts, kuh-seng 10 ~ 15 parts, climbing groundsel 10 ~ 15 parts, kaempferia galamga 10 ~ 15 parts, calamus 10 ~ 15 parts, tarragon 10 ~ 15 parts, borneol 10 ~ 15 parts, the flower bud of lily magnolia 10 ~ 20 parts, the root of Chinese wild ginger 10 ~ 20 parts, cloves 10 ~ 20 parts, windproof 10 ~ 20 parts, cassia twig 10 ~ 20 parts, Chinese cassia tree 10 ~ 20 parts, rhizoma cyperi 10 ~ 20 parts, the bletilla striata 10 ~ 20 parts, eupatorium 10 ~ 20 parts, pelargonium 10 ~ 20 parts.

Described Chinese medicine expelling parasite additive, is characterized in that, the parts by weight of the various bulk drug of described Chinese medicine expelling parasite additive are: rhizoma atractylodis 10 ~ 20 parts, peppermint 10 ~ 20 parts, Radix zanthoxyli 10 ~ 20 parts, kuh-seng 10 ~ 20 parts, climbing groundsel 10 ~ 20 parts, kaempferia galamga 10 ~ 20 parts, calamus 10 ~ 20 parts, tarragon 10 ~ 20 parts, borneol 10 ~ 20 parts, the flower bud of lily magnolia 10 ~ 15 parts, the root of Chinese wild ginger 10 ~ 15 parts, cloves 10 ~ 15 parts, windproof 10 ~ 15 parts, cassia twig 10 ~ 15 parts, Chinese cassia tree 10 ~ 15 parts, rhizoma cyperi 10 ~ 15 parts, the bletilla striata 10 ~ 15 parts, eupatorium 10 ~ 15 parts, pelargonium 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Chinese medicine expelling parasite additive, it is characterized in that, the preparation method of described Chinese medicine expelling parasite additive comprises the following steps:

A. get all bulk drug way of distillations and be vaporized into crystallization, pulverize dusting cover stand-by, as component 1;

B. distillation test residue ethanol heat is extracted 2 times, merge concentrated extracting solution, as component 2;

E. mix well after component 1 being mixed with component 2, sterilization tinning is stand-by.

In described step a, first all bulk drug steam methods can be distilled, obtain crystal, then pulverize, cross 120-150 mesh sieve, for subsequent use as component 1.

In described step b, the residue of the bulk drug that the way of distillation can be extracted, add the alcohol immersion 4-6 hour accounting for its quality 5-10 times amount, heating extraction 2 times, each 1-2 hour, merge extract, remove supernatant after leaving standstill, then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.25 filtrate, as component 2.

In described step c, can the powder crystallization of pulverizing be mixed in the filtrate of component 2, stand-by after ultraviolet radiation for sterilizing and disinfecting.

For solving the problems of the technologies described above, present invention also offers a kind of peppermint underwear fabric, the raw materials of described underwear fabric comprises: the Chinese medicine expelling parasite additive of mint fibers and aforementioned any one.

The preparation method of described underwear fabric can comprise the following steps:

A. the purification step of mint fibers;

B. cellulosic activation step;

C. cellulose is at the dissolving step of copper ammon solution;

D. the step of spinning.

The step of described d. spinning may further include: the preparation of spinning solution, filtration, deaeration, regeneration, pickling, washing, hot gas spring.

The present invention adopts multiple extracted form natural plant composition, naturally gentle, can stop bite by mosquitos, also can alleviate rapidly the discomfort after bite by mosquitos, the pure gentleness of product, non-stimulated, gives the skin of adult and the safer care of adult.People is allowed to invade and harass away from mosquito in summer.The natural gentleness of the present invention, safety, non-greasy, snug fit.

The technique effect that the present invention is useful is, provides a kind of novel underwear fabric.Have the research much about expelling parasite arrangement and expelling parasite textile material although domestic, mostly there is obvious defect, it is poor to drive buffalo gnat fly persistence.The present invention is with mint plants and naturally drive the agent of buffalo gnat fly for raw material, utilizes copper ammon solution wet spinning to produce regenerated celulose fibre.This production method is a kind of free of contamination Green production method, has good market prospects, and at home and abroad insect-repellent fiber developing material still belongs to the first.Overall merit is carried out by the structure of the anthelminthic effect to prepared expelling parasite regenerated celulose fibre, fiber, physical and mechanical properties and textile printing and dyeing machinability, determine the optimum process scheme preparing expelling parasite regenerated celulose fibre, can develop the expelling parasite regenerated celulose fibre with persistent high efficiency, expelling parasite regenerated celulose fibre prepared by the present invention is the basis of the exploitation carrying out all kinds of Worm-expelling fabric.The expelling parasite textiles utilizing this expelling parasite regenerated celulose fibre to develop, can replace the expelling parasite textiles developed by Final finishing, greatly reduces cost and the pollution to environment like this, improves the actual application value of expelling parasite type textiles.

Insect-repellent fiber material of the present invention has important meaning mainly to comprise the following aspects:

(1) the expelling parasite regenerated celulose fibre prepared is the basis of carrying out all kinds of Worm-expelling fabric exploitation, because insect-repellent fiber material inherently possesses the function for expelling pests needed for people, this material is utilized can directly to develop expelling parasite textiles, can replace by Final finishing exploitation expelling parasite textiles, simultaneously, enhance validity and the persistence of function for expelling pests, greatly reduce costs and the pollution to environment, improve the actual application value of expelling parasite textiles.

(2) natural expelling parasite Chinese medicine additive is adopted, poison less and have no side effect environment, the expelling parasite regenerated celulose fibre of preparation is a kind of novel green fiber, can natural degradation, meeting these themes of the times of environmental protection, is a kind of promising cellulosic fibre material.

(3) this technology is also for other specific functionality textiless of exploitation point the direction, as persimmon leaf can be utilized, there is the pharmacological properties such as anti-oxidant, hemostasis, reducing blood lipid, with persimmon leaf for raw material, adopt the production technology of this project, preparation has the medical material of hemostatic function.

Accompanying drawing explanation

Fig. 1 is Chinese medicine pest repellant vitro antibacterial activity table described in the embodiment of the present invention;

Fig. 2 is Chinese medicine expelling parasite additive repelling effect table described in the embodiment of the present invention;

Fig. 3 is Chinese medicine expelling parasite additive site test results described in the embodiment of the present invention;

Fig. 4 is Chinese medicine fabric insect-repellent fiber preparation technology flow chart described in the embodiment of the present invention;

Fig. 5 is Chinese medicine fabric experiment anthelminthic effect table described in the embodiment of the present invention.

Detailed description of the invention

Describe embodiments of the present invention in detail below with reference to embodiment, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Mint fibers characteristic: Compendium of Material Medica the 14 volume: " peppermint, cauline leaf smell is pungent, warm, nontoxic, cure mainly harmful wind typhoid fever, sweating bad odor trusted subordinate turgor, cholera, place food do not disappear, lower gas, sweating, have a bowel movement tired." common peppermint has peppermint tea, menthol ointment, peppermint candy etc.

Mint fibers herbaceous plant concept, the spinning property that feel is smooth, excellent, product applicability are wide.

Mint fibers function: the natural harmless antibiotic effect of mint fibers, washs after 50 times, still higher than national antibacterial standard.And possess the natural cool feeling of mint fibers.

Mint fibers antibiotic facing material of the present invention, takes from natural, is dissolved in natural, and injects at spinning phase, and persistence is strong, and cost is lower, and technique is relatively simple, is applicable to ruck consumption.

The natural peppermint of the present invention's " mint fibers " raw material abstraction, serves brand-new pioneering contribution for the with serious pollution situation of antibiotic facing material complex process in the industry, has had very large contribution to energy-saving and emission-reduction environmental protection.

The traditional production method of regenerated celulose fibre mainly contains xanthate cotton and Fibre with Copper Ammonia Solution two kinds.Xanthates is a kind of solvent being used as dissolving cellulos the earliest, utilizes this solvent to be mainly used in the production of viscose or Cellophane (cellophane) fiber, and present stage, most of cellulose products was mostly utilize this explained hereafter.Xanthate cotton dissolving cellulos is a complex process comprising chemical reaction, its dissolution mechanism first the process of cellulose highly basic is generated alkali cellulose, sodium cellulose xanghate is obtained by reacting again with carbon disulfide, then be dissolved in NaOH, while spinning solution is extruded, intermediate compound is converted into cellulose again, can obtain viscose.The major defect utilizing this cellulose solvent to develop fiber can release CS in whole production process ₂and H ₂the toxic gases such as S, pollute air and water, and this is the biggest obstacle hindering this cellulose dissolution to develop for a long time.Utilize copper ammon solution to be another traditional production method to produce regenerated celulose fibre, except copper ammon solution, cupri-ethylene diamine solution also may be used for dissolving cellulos, consistent with copper ammon solution solution principle.Copper ammonia complexation ion in solution can form cellulose derivative with cellulose, and then makes cellulose dissolution, and the dissolubility of its solution is relevant with the degree of polymerization that the concentration of copper ammonia complexation ion, cellulose slurry are moored and solution temperature.

Novel cellulose production technology mainly contains: cellulose carbamate (also known as CC) method, production technology such as N-methylmorpholine-N-oxide (NMMO) method and ionic liquid etc.

A. cellulose carbamate (CC) method: this spinning production technology synthesizes basis, the cellulose production new technology grown up gradually with cellulose carbamate.Concrete technology flow process be first with saturated aqueous solution of urea to cellulose preliminary treatment, then at high temperature react and be converted into carbaminate, be finally dissolved in NaOH solution, formed spinning solution.

B.N-methyhnorpholine-N-oxide (NMMO) method: utilize N-methylmorpholine-N-oxide (NMMO) dissolving cellulos, carry out cellulosic production, NMMO is considered to the most promising organic solvent, successfully develops Lyocell fiber with this solution-polymerized SBR.Find that NMMO can dissolving cellulos well people such as Graenacher in 1939, obtain fibroblast, cellulose solution that filming performance is good.NMMO is a kind of aliphatic cyclic tertiary amino oxides, and syntheti c route is that first diethylene glycol (DEG) and ammonia react generate morpholine, then through methylating and H ₂o ₂the dissolution mechanism that oxidation obtains NMMO.NMMO dissolving cellulos is that the hydrogen bond of cellulose inside is replaced by the hydrogen bond between solvent molecule and cellulosic molecule and dissolves.Strong polarity containing N-O key in NMMO, oxygen atom can form hydrogen bond with the hydroxyl of cellulose inside.First NMMO has an effect with the fiber of noncrystalline domain, then progressively enters cellulosic crystal region, and then destroys cellulosic supramolecular structure, finally makes cellulose be dissolved fully.It has the high and excellent DIMENSIONAL STABILITY of intensity to utilize this cellulose dissolution successfully to develop Lyocell fiber, is the green fiber in 21st century.But this cellulose solvent price compared with high, byproduct of reaction is many, dissolution conditions be difficult to control and reclaim difficulty etc. defect, need to study further, this cellulose dissolution just can be made to reach and utilize widely.

C. ionic liquid: refer to the liquid be made up of ion be in a liquid state lower than 100 DEG C in temperature.It has cellulose different from other, does not have electroneutral molecule in ionic liquid, is all anion and cation.

Ionic liquid not only can dissolving cellulos, also can dissolve most of inorganic matter, organic matter and macromolecular material simultaneously.Ionic liquid also can as the catalyst of some reaction.Because ionic liquid can not form steam, therefore can not pernicious gas be produced in process of production, avoid and in use cause environmental pollution, be called as eco-friendly green solvent.All in all ordorless, pollution-free, the difficult combustion of ionic liquid, easily separated and easily reclaim advantages such as can repeated multiple timesly recycling, make it become the ideal substitute of traditional volatile organic solvent.Ionic liquid nitro ethamine (EtNNO3) is the earliest synthesized in 1914 by Walden; Then in 1948, Hurley has waited the fluid containing N-ethylpyridine cation.

Present stage, also little to the research of insect-repellent fiber, expelling parasite regenerated celulose fibre is still belonged to the first at home and abroad.The present invention mainly comprises the following aspects:

(1) pre-treatment of mint fibers element and other raw material, comprises cellulose and purifies and activation;

(2) dissolubility of mint fibers in copper ammon solution, cellulose copper ammon solution rheological property;

(3) preparation method of expelling parasite regenerated celulose fibre, mainly comprises coagulating bath to nascent insect-repellent fiber structure and the impact of tensile property, the lifting etc. of tensile fiber performance;

(4) structure of expelling parasite regenerated celulose fibre and physical and mechanical properties, disinsectization performance.

The present invention for raw material, utilizes Fibre with Copper Ammonia Solution with mint fibers and cellulose pulp, adopts wet spinning to prepare expelling parasite regenerated celulose fibre.The expelling parasite regenerated celulose fibre of research and development is one of important source material of exploitation expelling parasite textiles.

Cellulosic purification is exactly make cellulose and wax, pectin and lignin separation, obtains the product that cellulose purity is higher.Cellulosic purification mainly contains chemical method and the large class of bioanalysis two.Bioanalysis mainly utilizes corresponding enzyme to remove impurity to carry out cellulosic purification, and chemical method uses more a kind of cellulose purification means at present.

Mint fibers is except being rich in cellulose, and the compositions such as hemicellulose, lignin, pectin, wax also account for significant proportion.In mint fibers, hemicellulose level is larger, content is greatly about about 22%, its content is higher, the wax average content 8.72% of mint fibers, be greater than common native cellulose fibre as flax, cotton and kapok etc., carry out the exploitation of mint fibers, the removal of wax is particularly important, the pectin content of mint fibers is about 1.23%, substantially suitable with the pectin content of cotton fiber.In view of the cellulose purity of mint fibers is lower, be necessary before use to carry out cellulose purification.

1, the purification of mint fibers element:

(1) pre-treatment of raw material:

The peppermint herb be collected is dried in vacuum drying oven, utilizes high speed medicinal herb grinder to pulverize, obtain mint fibers element powder.

(2) removal of pectin and wax:

By aforementioned mint fibers powder washing several times, carry out suction filtration, ceaselessly repeatedly wash with the mixture of ethanol and benzene in the process of suction filtration, then in the ammonium oxalate of 12%, soak 4-5 hour, again dry after 3 washing suction filtrations, just obtain the product getting rid of wax and pectin.

(3) other appendicular removals:

The product removing wax and pectin is utilized respectively the dilute sulfuric acid of 5% and 10% sodium bicarbonate circulation immersion, clean 3 times, each 2-3 hour, removes lignin and hemicellulose, and then carries out suction filtration washing, by sample drying, just obtain pure cellulose product.

2, cellulosic activation

Cellulosic activation is one of key link preparing insect-repellent fiber, and the quality of activation is directly connected to the quality of spinning solution, and then affects the quality of fiber product.Physical method can be divided into activate for fiber activation and chemical method activates.Physical method activation mainly contains the technological means such as steam explosion technology, high energy electron irradiation and microwave and ultrasound process, physical method activation can under the prerequisite meeting requirement of experiment, decrease the use of chemicals, avoid environment, its technological process is also short, and present stage adopts physically activated method mostly.The cellulosic reagent of chemical activation mainly contains: the system of NaOH, liquefied ammonia, acetone and various dissimilar mixed solvent composition.

The invention provides 2 kinds of different activation methods:

(1) alkali activation: take the mint fibers 50Kg after purification, be placed in the container filling 11%-14% NaOH and process 6-8 hour, then filter, wash, until water lotion is close to PH value neutrality, take out the fiber after cleaning, dry to constant weight with vacuum drying oven, be placed in drier and cool, for subsequent use.

(2) acid activation: take the mint fibers 50Kg after purification, be placed in the container filling 10%-13% dilute sulfuric acid and process 6-8 hour, then filter, wash, until water lotion is close to PH value neutrality, take out the fiber after cleaning, dry to constant weight with vacuum drying oven, be placed in drier and cool, for subsequent use.

3, cellulose is in the dissolving of copper ammon solution

The present invention adopts copper ammon solution as cellulose solvent, carries out the production of insect-repellent fiber.Utilize regenerated celulose fibre prepared by copper ammon solution dissolving fiber, fiber is softly smooth, close with Real silk properties, and hygroscopicity is strong, good permeability, intensity is high, drapability is good, and owing to using wet spinning, fiber cross section is sub-circular, without skin-core structure, have all advantages that natural fabric has, can not produce toxic gas after burning, environmental-protecting performance is good.

Excessive sodium hydroxide solution is added, by gained Cu (OH) in copper-bath ₂precipitate suction filtration, washing several times, to get rid of Na ⁺with SO ₄ ^2-impact, then add slowly concentrated ammonia liquor make Kocide SD precipitate just disappear, obtain navy blue copper ammon solution.Concentrated ammonia liquor concentration used is that between 25-28%, density is about 0.91g/ml, and substance withdrawl syndrome is about 13.3molL ^-1.Cu (OH) is dissolved in the ammoniacal liquor of 100L ₂quality slightly larger than 1Kg.By the mint fibers after activation and the mixture (wherein the mass ratio of mint fibers and cotton fiber is 1:10 ~ 1:5) of cotton cellulose, be dissolved in aforementioned preparation at 40-46 DEG C and be dissolved in copper ammon solution, form the cellulose dopes of 5 ~ 10%.Afterwards, the Chinese medicine expelling parasite additive of the present invention of 2%-10% is added wherein.

Vast territory and abundant resources in China, abounds with various natural Chinese medicinal herb.Chinese herbal medicine is traditional culture marrow.Traditional Chinese medicine theory is combined with modern science and technology, by various modern techniques such as refinement, extractions, Chinese medicinal herb essence is used for mosquito repellent product series, spy have developed herbal type high-quality and drives kill mosquito product, adopts multiple extracted form natural plant composition, naturally gentle, the discomfort after bite by mosquitos can be alleviated rapidly, the pure gentleness of product, non-stimulated, give the care that the skin of adult is safer.Quite popular in America and Europe, Japan and other countries and area as brand-new deinsectization underwear.Research shows, because invention Chinese medicine expelling parasite additive has unique release function, outside decapacitation mosquito repellent, also have get rid of peculiar smell, inspire enthusiasm, the advantage such as antibiotic health care, have good application prospect.

In laboratory conditions, the present invention observes repelling effect of the present invention with aedes albopictus and culex.Result shows, and Chinese medicine mosquito repellent additive of the present invention has certain repellent effect to for examination mosquito, and its juice effectively can prevent bite by mosquitos, and also has stronger smoked kill effect to multiple mosquito in confined conditions.

Rhizoma atractylodis are pungent, bitter, temperature.Return spleen, stomach, Liver Channel.Function cures mainly: drying damp and strengthening spleen, expelling wind and clearing away cold, improving eyesight.For abdominal fullness and distention, oedema of having loose bowels, beriberi Wei lame, arthralgia due to wind-dampness, anemofrigid cold, yctalopia.Main the spleen and stomach being stranded by dampness; Burnout is addicted to sleeping; Born of the same parents' ruffian abdominal distension; Poor appetite; Tell and have loose bowels; Phlegm and retained fluid; Wet swollen; Illness that has not attacked the vital organs of the human body folder is wet; The heavy pain of head body; Bi Zheng warm nature; Podomere is ached and is weighed; Impotence folds in a garment.Rhizoma atractylodis have drying damp and strengthening spleen, effect of wines used as antirheumatic.Cure mainly damp retention in middle-jiao, wind-cold-dampness arthralgia, pin swelling and pain in knee, impotence is soft unable, night blindness yctalopia." shell of seaear capsule " day: " stomach invigorating can pacify spleen, all wet swollen non-these can not remove." Compendium of Material Medica says: " control wet phlegm and stay drink ... and spleen wets dirty, under turbid drop band, slide and rush down intestines wind." " Tang materia medica " claim it can " diuresis ".

Bletilla striata property is bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatism and bleeding, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.Shennong's Herbal: " main carbuncle swells, dislike sore, lose subcutaneous ulcer, the dead flesh of impairment of yin, perverse trend in stomach "; Compendium of Material Medica: " smell (root) is bitter, flat, nontoxic.

The flower bud of lily magnolia is warm in nature, the pungent micro-hardship of taste.Gui Jing attaches to the lung and stomach meridians.Dispersing wind and cold, clearing the nasal passage.For anemofrigid headache, nasal obstruction, nasosinusitis, turbid nasal discharge." herbal classic ": main the five internal organs health fever and chills, public attention cerebralgia, face acid anhydride." not Lu ": expelling pathogenic factors from muscles and skin in temperature, sharp nine orifices, logical nasal obstruction, tears go out, and control edema of the face and draw dentalgia, and vertigo, body are several as person on car and boat.Raw beard and hair, goes white worm." property of medicine opinion ": can acid anhydride of looking unfamiliar be controlled.Face fat use, key light China.

The root of Chinese wild ginger, Chinese medicine name, cures mainly: dispel the wind, and loose cold, row water, has one's ideas straightened out.Control air-cooled headache, nasosinusitis, dentalgia, phlegm and retained fluid is coughed inverse, arthralgia due to wind-dampness.All herbal medicine, with being antipyretic, diuresis, analgesia, sedative.Control headache, the effect of have sweating, eliminating the phlegm.Exterior syndrome due to wind-cold; Headache, toothache; Arthralgia due to wind-dampness; Phlegm and retained fluid is coughed and is breathed heavily; Nasal obstruction; Nasosinusitis; Aphtha.Refrigeration function Herba Asari volatile oil gavages has obvious refrigeration function to the rabbit experiment heat pyrexia of many reasons caused by Wen Cifa, tetrahydrochysene beta-naphthylamine, typhoid fever, paratyphoid polyvalent vaccine, also has obvious antipyretic response to the rat fever caused by brewer's yeast.The body temperature of normal rat can also be reduced.

Cloves: enter liver, kidney two warp.Function cures mainly eliminate indigestion, and disappear screen.Control hernia lump in the abdomen, disease addiction, order screen, the triangular mass of mucous membrane growing from the inner corner of the eye, carious tooth.Treat order pain, certainly carbuncle furuncle, woman is with down, drowns unfavorable, except hernia lump in the abdomen." daily book on Chinese herbal medicine ": " remove freckle on face, acne.”

Pelargonium Classification system Pelargonium hortorum Bailey. smell is sweet and slightly weigh, a little as rose, again slightly as peppermint.Historical clinical record: be once used to treatment cholera and bone injured, also have the effect of exorcising a demon.Effect: hemostasis, vasoconstriction, asthma, liver and expelling toxin, gall stone, kidney toxin expelling, kidney stone, diuresis, msuscle soreness, Oily, aging skin activates, bleb, ochrodermia, and fat-reducing, promotes to scab, eczema, sunburn of burning, tinea, menstruation has some setbacks, engorgement of breasts inflammation, alleviates melancholy uneasy, mends body, deodorizing, antibacterial, sterilization. pelargonium is neural tonic, can put down and comfort anxiety, dejected, can also improve mood.Allow mental recovery balance, and because it also can affect adrenal cortex, therefore it can relieve pressure.

Peppermint is one of Chinese conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, the disease such as headache, hot eyes, body heat, throat, gum swell and ache.Place is with controlling neuralgia, pruitus, fash and eczema etc.The peppermint of light friend Greenhouse Fruit Picking is again the fresh vegetable on dining table in the Spring Festival.Clearly good to eat.Usually with peppermint for tea, clear away heart-fire improving eyesight.Peppermint has medical and edible dual-use function, and main Leaf-feeding insects is stem and leaf, clothes of also can squeezing the juice.On edible, peppermint both can be used as flavor enhancement, can make spices again, also can join wine, make tea.In every 100 grams of dried peppermints, moisture content 9.6 grams, 6.8 grams, protein and fiber 31.1 grams, can provide the heat of 870.7 kilojoules.

Radix zanthoxyli (formal name used at school: Zanthoxylum nitidum(Roxb.) DC.) root of Radix zanthoxyli, stem, leaf be used as medicine.Faling apart, the stasis of blood is active, removing toxic substances of dispeling the wind.The whole year all can excavate, and cleans, and section or section, dry.Aubergine when Follicle radish fruit is ripe, has thick gland point, the short beak of the positive tool in top.There is promoting qi circulation and relieving pain, the effects such as promoting blood circulation to remove blood stasis.Can be used for traumatic injury, arthralgia due to wind-dampness, stomachache, toothache, venomous snake bite etc.Leaf and pericarp can carry aromatic oil; Seed oil is for soap system.

Kuh-seng, Chinese medicine name.For the dry root of legume kuh-seng, spring, Qiu Erji excavate, removing root head and little supporting root, cleaning, drying, or take advantage of fresh slices, dry.It is bitter, cold.There is heat-clearing and damp-drying drug, desinsection, the merit of diuresis.For hot dysentery, have blood in stool, jaundice renal shutdown, leukorrhea with reddish discharge, swelling of vulva pruritus vulvae, eczema, wet sore, pruitus, mange leprosy, controls trichomonas vaginitis outward.

Climbing groundsel (Senecio scandens Buch.-Ham. ex D. Don), has another name called nine li of bright, Herba Senecionis Scandentis, Broomjutre Sida Herb, Kowloon light, nine ridge light.The effects such as be a kind of Chinese herbal medicine, it is cold in nature, bitter, has clearing heat and detoxicating, improving eyesight, antipruritic.Be used for anemopyretic cold, red eye, swell pain, dysentery, skin eczema sore furuncle.

The pungent perfume (or spice) of kaempferia galamga gas, pungent, taste is sweet, pungent.Large with sheet, full, the pungent person of giving off a strong fragrance of look white is good.Nature and flavor and function pungent, temperature.Return spleen, stomach warp.Warming middle-JIAO for eliminating dampness, promoting qi circulation and relieving pain.For chest abdomen crymodynia, cold-dampness is vomited and diarrhoea, bone sticking larynx, toothache, treating swelling and pain by traumatic injury etc.

Calamus: bitter, pungent, temperature.Reduce phlegm, have one's ideas straightened out, invigorating the spleen, dampness removing.For epilepsy, palpitate with fear forgetful, clouded in mind, humidity hysteresis ruffian is swollen, dysentery, rheumatalgia pain, and carbuncle swells scabies.Calamus its flower, stem aromatic flavour, have have one's ideas straightened out, eliminate the phlegm, effect of loose wind, epidemic disease of can dispelling intelligence development, to improve the health.The successive dynasties classic of TCM is all using the medicine of calamus rhizome as the wide chest of intelligence development, hearing-improing and eyesight improving, clearing damp removing toxic substances.

Tarragon prevention pestilence has the history of several thousand, Chinese herbal medicine can be gathered materials on the spot, and the pharmacological research of modern medicine shows that tarragon is a kind of medicine of broad-spectrum antibacterial antiviral, it has suppression and lethal effect to a lot of virus and bacterium, has certain preventive and therapeutic effect to respiratory disease.Tarragon taste is pungent, bitter, warm in nature, nontoxic; Return spleen, liver, kidney channel; Fragrance temperature is loose, can rise and can fall. there is warming channel for arresting bleeding, eliminating cold to stop pain, effect of wet down desinsection. cure mainly irregular menstruation, dysmenorrhoea, fertility, fetal irritability, trusted subordinate's crymodynia, spits blood, bleeding from five sense organs or subcutaneous tissue, and spitting of blood, has blood in stool, uterine bleeding, gestation hemorrhage, have loose bowels protracted dysentery, under band, eczema, mange, carbuncle swells, hemorrhoid.Moxibustion treatment all kinds of diseases and ailments.

Borneol has another name called sheet brain, tangerine sheet, L-Borneol, kapur, MEIHUA BINGPIAN, Dipterocarpus pilosus, plum blossom brain, borneol brain, Mei Bing etc., is also to be recrystallized through steam distillation by composite family Blumea balsamifera cauline leaf or canella borneol camphor tree branches and leaves and to be obtained.Also useful turpentine oil obtains through a series of chemical method technique.It can be used for closing card coma, for red eye, swell pain, larynx numbness aphtha, to swell and ache for sore, does not hold back after bursting.

Windproof Chinese medicine name.Another name copper rue, Hui Yun, return grass, hundred, hundred kinds.Windproof Gen Kesheng uses.Taste is pungent, sweet, slightly warm in nature.Expel pathogenic wind from the body surface, removing dampness to relieve pain, only effect of convulsion.For diseases caused by external factors illness that has not attacked the vital organs of the human body, rubella itch, arthralgia due to wind-dampness, lockjaw just, the insufficiency of the spleen with overabundance of dampness.Compendium of Material Medica: " wind as 36, goes part of the body cavity above the diaphragm housing the heart and lungs ailment said due to cold or exposure, the stagnant gas of the head, and channels and collaterals stay wet, all over the body pain all over the joints.Except wind dries elixir." " medicine class method resembles ": " control wind general.Purging the lung of pathogenic fire is real, stagnant gas in the loose head, except the part of the body cavity above the diaphragm housing the heart and lungs is evil.”

Its nature and flavor of cassia twig are pungent, sweet, temperature, enter lung, the heart, urinary bladder channel, cure mainly the conventional drugs for dispelling internal cold of interior cold, there is effect of complement sun, promoting blood circulation, warming spleen and stomach, normal with filling liver kidney medicine, fill blood medicine compatibility, treats the insufficiency of the kidney yang, the Yang-function insufficiency of kidneyzang, the cold weak pulse of limb, treat coldness and pain in the epigastrium, arthritis pain in the back with other drugs for dispelling internal cold compatibility, there is the effect of significantly analgesia and anti-cancer and cancer-preventing.Existing various wind dispelling oils medicine is if cooling ointment, rheumatism wet goods are all containing oil of bay composition.

Chinese cassia tree complement sun, warming spleen and stomach, removing internal cold, promoting blood circulation.Control the Yang-function insufficiency of kidneyzang, the cold weak pulse of limb, yang depletion is collapsed, and stomachache is had loose bowels, and cold hernia is run quickly globefish, waist knee crymodynia, through closing abdominal mass, and cloudy subcutaneous ulcer, streamer, and empty sun is more floating, heat in the upper and cold in the lower." herbal classic ": Your Majesty's gas is coughed inverse, knot gas larynx numbness tells suction, sharp joint, tonifying middle-Jiao and Qi." not Lu ": main pained, side of body wind, hypochondriac pain, warm muscle, promotes blood circulation, only tired, perspire.In main temperature, benefitting liver and lung gas, trusted subordinate's fever and chills, cold disease, choleraic myospasm, headache, pain in the back, only saliva, cough ， Bi Weng: can have an abortion, hard joint, promoting blood circulation, reason is dredged not enough; A surname leads hundred medicines, without feared.

Rhizoma cyperi is regulated the flow of vital energy Xie Yu; Menstruction regulating and pain relieving; Antiabortive.The main distending pain in hypochondrium; Spargosis is educated; Hernia pain; Irregular menstruation; The full pain of gastral cavity abdomen ruffian; Belch acid regurgitation, evil of vomitting; Dysmenorrhea; Under uterine bleeding band; Fetal irritability.For stagnation of QI due to depression of the liver, chest, the side of body, abdominal distention, indigestion, chest gastral cavity ruffian is vexed, and cold hernia stomachache, swollen breasts, irregular menstruation, through closing dysmenorrhoea.

Eupatorium: experience summer-heat and damp; Fever and chills are had a headache; Accumulate in moistening; Gastral cavity ruffian is not hungry; N and V; Sweet greasy in mouthful; Disappear truly.For turbi damp obstructing in middle-JIAO, gastral cavity ruffian is vomitted evil, and sweet greasy in mouth, halitosis, polysialia, summer-heat and damp table disease, alliteration is uncomfortable in chest." herbal classic ": main dredging water passages, kills disease due to noxious agents produced by various parasites." Chinese medicinal herbal ": deliver clearing damp, and middleization is turbid.Control summer-heat headache, lossless heating, abdomen uncomfortable in chest is full, sweet greasy in mouth, halitosis." detailed outline ": subduing inflammation, adjusts menstruation. and " modern Practical Chinese medicinal ": be armaticity stomach invigorating, sweating, diuretics.For emitting cold headache, nasal obstruction, nervous headache, infectiousness pyreticosis, stomachache, waist nephralgia, calculus etc.

Specific embodiment 1

By rhizoma atractylodis 1000g, peppermint 1000g, Radix zanthoxyli 1000g, kuh-seng 1000g, climbing groundsel 1000g, kaempferia galamga 1000g, calamus 1000g, tarragon 1000g, borneol 1000g, flower bud of lily magnolia 1000g, root of Chinese wild ginger 1000g, cloves 1000g, windproof 1000g, cassia twig 1000g, Chinese cassia tree 1000g, rhizoma cyperi 1000g, bletilla striata 1000g, eupatorium 1000g, pelargonium 1000g, is vaporized into crystallization by the way of distillation, grinding and sieving, crosses the dusting cover of 120-150, stand-by, as component 1; Soaked by bulk drug residue after vaporization, heating boils 3 times, each 1-2 hour, and filter, filtrate is for subsequent use; To merge in the filtrate suction reduced pressure concentration tank of latter 3 times, being evaporated to relative density is 1.20, the medicinal extract of temperature to 60 DEG C-70 DEG C; Become component 2, blending ingredients 1 and component 2, add with ultraviolet disinfection stand-by.

Specific embodiment 2

By rhizoma atractylodis 1200g, peppermint 1200g, Radix zanthoxyli 1300g, kuh-seng 1200g, climbing groundsel 1200g, kaempferia galamga 1200g, calamus 1200g, tarragon 1100g, borneol 1200g, flower bud of lily magnolia 1200g, root of Chinese wild ginger 1200g, cloves 1200g, windproof 1200g, cassia twig 1200g, Chinese cassia tree 1100g, rhizoma cyperi 1100g, bletilla striata 1200g, eupatorium 1100g, windproof 1100g, camphor 1100g, is vaporized into crystallization by the way of distillation, grinding and sieving, crosses the dusting cover of 120-150, stand-by, as component 1; The bulk drug residue that vaporization was extracted is added in the ethanol of 5-10 times amount and soaks 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extract, remove supernatant after leaving standstill, then 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, stand for standby use, becomes component 1.The dregs of a decoction of the bulk drug that above-mentioned alcohol extract is crossed add 10 times of water gagings, heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by No. 2 extracts and leave standstill, become component 2.By the merging of component 1 and component 2, add with ultraviolet disinfection stand-by.

Specific embodiment 3

By rhizoma atractylodis 1300g, peppermint 1200g, Radix zanthoxyli 1300g, kuh-seng 1200g, climbing groundsel 1100g, kaempferia galamga 1200g, calamus 1300g, tarragon 1400g, borneol 1200g, flower bud of lily magnolia 1200g, root of Chinese wild ginger 1200g, cloves 1200g, windproof 1200g, cassia twig 1200g, Chinese cassia tree 1400g, rhizoma cyperi 1300g, bletilla striata 1200g, eupatorium 1100g, windproof 1300g, camphor 1100g, is vaporized into crystallization by the way of distillation, grinding and sieving, cross the dusting cover of 120-150, stand-by, as component 1, the dregs of a decoction of the bulk drug extracted of vaporizing are soaked 1 hour; Put boiling secondary in multi-function extractor; Add up the water of medicinal material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds the water of total amount 7 times amount, decocts 1 ~ 1.2 hour, gets twice decocting liquid mixing, filters; The filtrate of filtration inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Will refrigeration liquid add 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount, as component 2, by the merging of component 1 and component 2, adds with ultraviolet disinfection stand-by.

Pharmacological toxicity is tested

Antibacterial tests of the present invention

Experiment material

1, animal subject: Kunming mouse, 18-22g, male and female half and half; Instar chicken embryo on the 9th.2, bacterium and virus: bacterial isolates is clinical separation strain, totally 97 strains; Flu virus FM1 strain.3, plate: MH culture medium; Streptococcus pneumonia adopts blood meida, in MH culture medium, namely adds 5% defiber sheep blood make; Haemophilus influenzae adopts chocolate culture-medium.

2, In vitro Bactericidal Experiments

1, the mensuration of external minimum inhibitory concentration (MIC)

(1) experimental technique: extract medicinal extract sterile saline by reagent (the present invention) and be diluted to following concentration gradient, i.e. 1600,800,400,200,100,50,25,12.5,6.25,3.13 (mg/ml), draw 1.5 ml respectively in sterilized petri dishes, add the sterilizing MH culture medium in the 55 DEG C of water-baths of 13.5 ml constant temperature again, after mixing, cooling is for subsequent use.The ultimate density of each Drug plates Chinese traditional medicine is 160,80,40,20,10,5,2.5,1.25,0.625,0.313 (mg/ml).Establish blank group simultaneously.The test organisms sterile saline cultivating 8-12h is diluted to desired concn (being generally 10 7 CFU/ml), and adopt multiple spot inoculation instrument to be connected to the Drug plates of variable concentrations, inoculum concentration is about 10 4 ~ 10 5 CFU.Test organisms in 37 DEG C of constant temperature culture, 24 hours observed results, and records MIC value.

(2) experimental result

In vitro Bactericidal Experiments result shows (see Fig. 1), medicine to the Grain-positive of the infection of the upper respiratory tract and Grain-negative clinical bacteria all inhibited, wherein to the MIC 50 of staphylococcus aureus, Staphylococcus epidermidis, streptococcus pneumonia, bloodthirsty Bacillus influenzae, Klebsiella Pneumoniae, Escherichia coli and Pseudomonas aeruginosa be respectively 10,20,20,2.5,40,20 and 10mg/ml, MIC 90 be respectively 80,40,80,20,160,40 and 160mg/ml.

Acute toxicity testing data

1, experimental technique

Hair remover is evenly coated by guinea pig back backbone both sides, makes unhairing scope about 40 square centimeters.Clean hair remover returns cage to observe 24 hours, often organize cavy and be coated with the present invention 0.2,0.4 and 0.8ml respectively, respectively containing crude drug 92mg, 184mg and 368mg), another group is coated with the every twice-daily of solvent 0.8ml, continuous one week, after experiment terminates, cavy is put to death, the heart, liver, kidney and depilation skin do pathological examination.

2, result

Above-mentioned three groups of medication cavy trunks depilation district, having no local skin has oedema, hyperemia, erythema, blutpunkte and ulcer.Medication group cavy chroma of hair, ingest, the control group no significant difference such as four limbs are movable, histopathologic examination, the administration group heart, liver, kidney and depilation skin with contrast word more also no significant difference.

Result is pointed out, and the present invention, without local irritant effect, also has no general toxicity performance.Show use safety of the present invention.

Long term toxicity test data

1, experimental technique

Random for cavy part is become 4 groups, often organizes 15.In guinea pig back backbone both sides, hair remover is evenly coated, make its scope about 40 square centimeters of losing hair or feathers.Clean hair remover, observe and often organize cavy after 24 hours and be coated with eye cream 0.2,0.4 of the present invention and 0.8ml respectively, respectively containing crude drug 92,184 and 368mg), another group is coated with the every twice-daily of solvent 0.8ml, continuous 30 days, observe the ordinary circumstance of cavy, experiment terminates rear execution animal and carries out hematology, blood biochemical and pathological examination.

2, result

Above-mentioned three groups of medication cavy trunk unhairing districts, having no local skin has oedema, hyperemia, erythema, blutpunkte and ulcer.Medication group and control animals chroma of hair, ingest, the control group no significant difference such as four limbs are movable, blood biochemistry checking, medication group and control group are all in normal range (NR).Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious pathology.Prompting, long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ.Result of the test shows: experiment safety of the present invention.

Pharmacology test

Object: the repelling effect testing dress material herbal medicine immersion liquid of the present invention.The author is verified by 4 groups and is evaluated.

1 materials and methods

1.1 test samples and equipment: prepare herbal medicine immersion liquid of the present invention by the method for embodiment 2.Column type glass mosquito cage (bottleneck 30 cm, high 30 cm), puts examination mosquito 90 in a suitable place to breed; Airtight good glass jar (60 cm × 35, cm × 30 cm), middle part separates with gauze, and examination mosquito 90 is put in left side; Mosquito net 3 pushes up (2 MM × 1M × 1.5).

1.2 sprout wings for examination mosquitoes after 4 ~ 5 d aedes albopictus (Aedes albopictus) of not sucking blood and culex (Culex.spp) female mosquitos, be and commonly disturb people mosquito kind.

1.3 experimental condition temperature (26 ± 1) DEG C, relative humidity (60 ± 5) %, tests and carries out in 19:00 ~ 21:00 mosquito peak period of sucking blood.

1.4 test method

1.4.1 effect of the present invention: test and prepare soak of the present invention according to the method for embodiment 2.Select 3 people in testing the different time on the same day by everyone 1ML liquid measure, be spread evenly across the skin exposed section of left hand the back of the hand 4 cm × 4 cm, with right hand the back of the hand in contrast, the back of the hand remainder all tightly covers.Successively the right hand and left hand are stretched into 5 min in glass mosquito cage during test, observe and record the mosquito number of times coming to stop and suck blood, calculating effective protecting time and protective rate.Effective protecting time calculates to come to stop the maximum duration of sucking blood without mosquito.

Protective rate (%)=right hand bite by mosquitos number of times-left hand bite by mosquitos number of times/right hand bite by mosquitos number of times × 100

1.4.2 both hands are stretched into the right-hand part of glass jar by repellency test, put into the liquid of the present invention of some simultaneously, and put into front bottle water spray, in 5 min, record rests in or collides the mosquito number of times on gauze.Often organize repetition 3 times, calculate protective rate.

1.4.3 smoked kill test is in 250 ml conical flasks, often bottledly enters to try mosquito 10.Getting fresh liquid 5ml, 10ml, 15ml of the present invention respectively to grind in mortar, then put into conical flask, closely seal with preservative film, often organizing repetition 3 times, with speckling with the absorbent cotton of distilled water in contrast.Observe and record examination mosquito all by time that smoked kill is lethal.

1.4.4 outdoor test selects intensive, the quiet calm place of mosquito, in propping 3 top mosquito nets at dusk, mosquito net bottom distance ground 20 cm, puts into 2 basin medicinal extract of the present invention respectively in two groups of mosquito nets, another 1 top is blank group, needs to spray water in tent during test.Enter mosquito net by 1 people respectively before 19:00, to observe every 0.5 h at l9:00 ~ 2l:00 later and record the mosquito number of times entering mosquito net, calculating protective rate.

2 results and analysis

As seen from Figure 2, the present invention has good repellent effect to mosquito to 2.1 juice repelling effects, and effective protecting time, at about 40 min, still maintains higher protective rate simultaneously in 1.5 h.

The present invention also has stronger repellent action to mosquito; a small amount of liquid can be achieved good results; and significantly improve along with the increase protective rate of amount of fluid, to 10ml, protective rate rises to more than 90%, also finds now to try distance that mosquito avoids in test within 10 cm.

2.3 smoked kill test effects try mosquito restlessness immediately after people's conical flask is put in the present invention, namely occur death after 5min.And the smoked kill time of examination mosquito and quality of the present invention are negative correlation, namely 15ml can make mosquito all lethal within the shortest time.

2.4 outdoor mosquito net tests carry out outdoor test with 2 basin the present invention; 19:00 ~ 21:00 each time period; 2 basin the present invention can reach the protective rate of average 55.96%; namely 4 basin protective rates rise to average 77.49%; in outdoor, spacious place has preferably repellent effect to mosquito in visible the present invention, and after increasing its quantity, repelling effect can significantly improve (see Fig. 3).

Quite popular in America and Europe, Japan and other countries and area as brand-new deinsectization underwear.Much research shows, because this underwear has unique release function, outside decapacitation mosquito repellent, also have get rid of peculiar smell, inspire enthusiasm, ease off the pressure, the advantage such as antibiotic health care, have good application prospect.

In laboratory conditions, we with aedes albopictus and culex the repelling effect to mosquitoes propagation observe.Result shows, and the present invention has certain repellent effect to for examination mosquito, and its juice effectively can prevent bite by mosquitos, and also has stronger smoked kill effect to multiple mosquito in confined conditions.The selection and the correct using method that find place in test are the prerequisites that the present invention receives applications well effect.

4, spinning

Spinning solution is extruded by spinning exactly under a certain pressure continuously uniformly from spinning head or spinneret hole, forms stoste thread, in air, water or other coagulating baths, is then solidified into the process of silk.According to the difference of shaping polymer nature, spinning process is mainly divided into melt spinning process and the large class of solution spinning two, and solution spinning is divided into dry spinning and wet spinning according to the difference of coagulating bath again.The fusing point of every high polymer is lower than its decomposition temperature, mostly adopt melt spinning process, adopt solution spinning on the contrary, because cellulose heat decomposition temperature is lower than fusion point temperature, directly can not carry out melt-processed, therefore the present invention adopts the wet spinning process in solution spinning to prepare insect-repellent fiber.

Wet spinning is the spinning solution that will prepare, after filtration, after the operation such as deaeration, join in spinning still, under the effect of nitrogen pressure, spinning solution is extruded from spinning head, and form stoste thread, thread directly enters coagulating bath, there is a series of reaction in the solvent in stoste and coagulating bath, makes fibre forming.In wet spinning process, the impact of curing condition on the Structure and Properties of as-spun fibre is most important.

(1) utilize light microscope to observe to cellulose course of dissolution in copper ammon solution, first result display cellulose occurs swelling in copper ammon solution, and then cellulose molecular chain constantly ruptures, and final cellulose dissolves completely.

(2) dissolubility of copper ammon solution is analyzed, find activated after the solubility of cellulose in copper ammon solution significantly improve, simultaneously the solubility of cellulose in copper ammon solution is along with Cu ²⁺the rising of concentration and increasing, from economic interests Cu ²⁺content should control between 18-20%; The solubility of the lower cellulose of temperature in copper ammon solution is higher, and determined temperature of the present invention is 0 DEG C.The dissolving of cellulose in copper ammon solution is very fast, and about about 2h just can dissolve completely.

(3) rheological property of cellulose copper ammon solution is studied.Find the rising along with temperature, viscosity declines gradually, therefore the temperature of spinning solution suitably should be controlled in the process of spinning, the viscosity of spinning solution increases along with the increase of content of cellulose, in addition expelling parasite Chinese medicine additive content is larger, and the viscosity of spinning solution is less, and as far as possible the parameter adopted in an experiment makes spinning solution keep low-temperature condition, cellulosic content is about 7%, and the content adding expelling parasite Chinese medicine additive is about 6%.

The 1000Kg copper ammon solution prepared is placed in container, add 10Kg activated after mint fibers, add the gossypin 50 ~ 100Kg after activation simultaneously, to regulate the concentration of cellulose copper ammon solution, temperature controls at about 0 DEG C, after utilizing agitator to stir 2h, add 0.2 ~ 0.8Kg emulsifying agent again, 2 ~ 10Kg pest repellant of the present invention, then stirs about 2h at normal temperatures, obtains spinning solution.

The emulsifying agent used in the present embodiment is peregal, English trade name: Peregal.Fatty alcohol-polyoxyethylene ether Alcohol Ethoxylate.Molecular formula is: RO-(CH ₂cH ₂o) n-H R=C _16-18n=9-30.There is good wet performance, and have good emulsification, dispersion, clean etc. performance.Fatty alcohol-polyoxyethylene ether, leveling agent o has another name called paregal O, belong to nonionic surface active agent, outward appearance is oyster white or ecru ointment shape, when molecular weight is higher, (chip solid can be made as requested) in solid shape, soluble in water, ethanol, ethylene glycol etc., have cloud point, 1% aqueous ph value is neutral.Can acidproof, alkaline-resisting, resistance to hard water, heat-resisting, resistance to heavy metallic salt.Have powerful level-dyeing property, slow metachromia, permeability, diffusivity to various dyestuff, during kiering, tool helps experienced performance, can with various surfactants and dyestuff with molten use.

Idiographic flow be first spinning solution will after filtration, after deaeration, under uniform temperature, nitrogen pressure, extrude from 30 × 0.2mm spinning head, then enter in diluted alkaline coagulating tank and carry out fibre forming, prepare as-spun fibre, again through post processings such as overpickling, stretching, wet heat setting, dryings, obtain the good insect-repellent fiber of mechanical property.

The technological process preparing insect-repellent fiber element as shown in Figure 4, mainly comprises: the preparation of spinning solution, filtration, deaeration, regeneration, pickling, washing, hot gas spring.

In the spinning solution prepared, also there is a lot of undissolved mint fibers and other impurity, the effect of filtering is exactly the not molten cellulose of removing and other impurity, if do not remove these impurity, spinning solution can not form stable thread when spinneret orifice sprays, the spinnability of solution declines, if impurity is too many, the blocking of spinneret orifice more can be caused, even if fiber can be shaped, also may form weak link in fibre structure, and then affect the intensity of fiber, in the process that spinning solution filters, a lot of bubbles can be produced, if before fibre forming, do not carry out deaeration process, the spinnability of spinning solution can be affected, difficulty is brought to spinning, even can cause fiber fracture of wire time serious, the carrying out namely allowing to maintain spinning also can cause the decline of fibrous mechanical property, due to the existence of bubble, the fiber of spinning can cause cavity or not tight at some position, and then affects the overall quality of fiber, the spinning solution prepared is by the extruding of stream of nitrogen gas, spinning solution is extruded by spinning head and is formed dynamic analysis of spinning, thread enters coagulating basin and coagulating bath generation mass exchange, cellulose is separated out again, now, because the fiber strand silk that exists of copper ion shows light blue, copper ion can be removed through pickling, fiber strand silk is bleached, the effect of washing removes the residual dilute sulfuric acid of previous operation pickling and other chemical substance, if do not remove dilute sulfuric acid, drying easily damages afterwards and can reduce the intensity of shaped fibers, simultaneously in hot gas spring operation, the nascent insect-repellent fiber goods charing of part can be caused.

As-spun fibre is made to obtain better physical and mechanical properties, need to carry out hot gas spring, make the cellulose macromolecule tanglewracked under the effect of external tensile force, axis along fiber forms neat arrangement, fiber after hot gas spring, cellulose macromolecule forms an organic whole, and the physical and mechanical properties of fiber increases.

The present invention tests proof, and when content of cellulose is about 6.5%, the intensity of nascent insect-repellent fiber is higher, content of cellulose lower than 6.5% time, the intensity of as-spun fibre increases along with the increase of content of cellulose, content of cellulose more than 6.5% after, the intensity of as-spun fibre diminishes gradually.The intensity effect of concentration to as-spun fibre of visible spinning solution is larger, in spinning experiment, content of cellulose is too low, not only has influence on the intensity of as-spun fibre, and causes as-spun fibre to produce weak ring at certain position, the spinning solution that content of cellulose is higher, the fibre structure of preparation is even and closely knit, but when content of cellulose is too high, brings difficulty to spinning, and the solubility of cellulose in copper ammon solution is also certain, the concentration of spinning solution should be adopted as seen to be about 6.5%.

Along with the increase of coagulating bath concentration, the brute force of fiber first increases, and increases to a certain degree, reduce gradually, and the optium concentration of coagulating bath is near 15%.The concentration of coagulating bath is too low, and precipitated phase needs more coagulating bath, entering in a large number of coagulating bath with the fiber of amount, make fiber loosely, fibre strength is lower, when coagulating bath concentration is larger, coagulating agent and solvent exchange too fast, cause fibre forming too fast, as-spun fibre intensity declined.The best coagulation bath temperature that the present invention tests proof is 35 DEG C.

Fiber anthelminthic effect is tested:

Both at home and abroad also do not have concrete standard for anthelminthic effect test, the test of anthelminthic effect is mostly that three standards drafting using the Ministry of Agriculture are as reference and reference.These three testing standards are respectively: GB 13917.1-1992 " assay method of the indoor harmacological effect of agriculture chemical registration hygienic insecticide indoor pharmacodynamic test method propellant ", GB/T 17322. 10-1998 " indoor harmacological effect of agriculture chemical registration hygienic insecticide evaluates repellant " and GB13917. 3-1992 " the indoor harmacological effect method of testing of the method compact smoke agent of agriculture chemical registration hygienic insecticide indoor pharmacodynamic test and smog sheet ".The present invention is with reference to these three standards, tests the actual anthelminthic effect of insect-repellent fiber.

(1) mosquito of collecting is imported to A room and the B room of mosquito-proof measure of merit case, the number of mosquito in two Room is consistent substantially; The salt water yield of getting 100% of equivalent as bait, is placed in the lower floor of A room and B room respectively in culture dish;

(2) mosquito is under the attraction of salt, after a while, when on the gauze that mosquito falls within A room and B room or when being arbitrarily dispersed in two indoor, the fiber without mosquito-proof effect is put in the upper strata of A room drawer, in contrast, mosquito-proof regenerated celulose fibre puts into the upper strata of B room drawer; Baffle plate about closing, observes the active situation of mosquito;

(3) after a few minutes, open the baffle plate between two Room, observe mosquito activity direction, when the land situation of mosquito is basicly stable, record the mosquito sum of two indoor.

Calculate the mosquito repellent rate of the mosquito-proof regenerated celulose fibre of different culicifuge content according to formula (1-1), the mosquito-proof effect of this fiber is evaluated.

Expelling parasite Chinese medicine additive content is respectively 3.5%, 5.2%, 7%(numbering 1#, 2#, 3#) insect-repellent fiber utilize expelling parasite testing arrangement, test anthelminthic effect, test result as shown in Figure 5:

As seen in Figure 5, the anthelminthic effect of insect-repellent fiber element is along with the increase of expelling parasite Chinese medicine additive content, anthelminthic effect is become better and better, tested from the present invention, expelling parasite Chinese medicine additive content is too large, brings certain difficulty, in actual production to the preparation of expelling parasite regenerated celulose fibre, obtain certain anthelminthic effect, the content adding expelling parasite Chinese medicine additive is no less than 5.2% and is advisable.

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

Claims (10)

1. a Chinese medicine expelling parasite additive, is characterized in that, comprises the bulk drug of following parts by weight: rhizoma atractylodis 10 ~ 20 parts, peppermint 10 ~ 20 parts, Radix zanthoxyli 10 ~ 20 parts, kuh-seng 10 ~ 20 parts, climbing groundsel 10 ~ 20 parts, kaempferia galamga 10 ~ 20 parts, calamus 10 ~ 20 parts, tarragon 10 ~ 20 parts, borneol 10 ~ 20 parts, the flower bud of lily magnolia 10 ~ 20 parts, the root of Chinese wild ginger 10 ~ 20 parts, cloves 10 ~ 20 parts, windproof 10 ~ 20 parts, cassia twig 10 ~ 20 parts, Chinese cassia tree 10 ~ 20 parts, rhizoma cyperi 10 ~ 20 parts, the bletilla striata 10 ~ 20 parts, eupatorium 10 ~ 20 parts, pelargonium 10 ~ 20 parts.

2. Chinese medicine expelling parasite additive according to claim 1, is characterized in that, comprise the bulk drug of following parts by weight: rhizoma atractylodis 10 ~ 15 parts, peppermint 10 ~ 15 parts, Radix zanthoxyli 10 ~ 15 parts, kuh-seng 10 ~ 15 parts, climbing groundsel 10 ~ 15 parts, kaempferia galamga 10 ~ 15 parts, calamus 10 ~ 15 parts, tarragon 10 ~ 15 parts, borneol 10 ~ 15 parts, the flower bud of lily magnolia 10 ~ 20 parts, the root of Chinese wild ginger 10 ~ 20 parts, cloves 10 ~ 20 parts, windproof 10 ~ 20 parts, cassia twig 10 ~ 20 parts, Chinese cassia tree 10 ~ 20 parts, rhizoma cyperi 10 ~ 20 parts, the bletilla striata 10 ~ 20 parts, eupatorium 10 ~ 20 parts, pelargonium 10 ~ 20 parts.

3. Chinese medicine expelling parasite additive according to claim 1, is characterized in that, comprise the bulk drug of following parts by weight: rhizoma atractylodis 10 ~ 20 parts, peppermint 10 ~ 20 parts, Radix zanthoxyli 10 ~ 20 parts, kuh-seng 10 ~ 20 parts, climbing groundsel 10 ~ 20 parts, kaempferia galamga 10 ~ 20 parts, calamus 10 ~ 20 parts, tarragon 10 ~ 20 parts, borneol 10 ~ 20 parts, the flower bud of lily magnolia 10 ~ 15 parts, the root of Chinese wild ginger 10 ~ 15 parts, cloves 10 ~ 15 parts, windproof 10 ~ 15 parts, cassia twig 10 ~ 15 parts, Chinese cassia tree 10 ~ 15 parts, rhizoma cyperi 10 ~ 15 parts, the bletilla striata 10 ~ 15 parts, eupatorium 10 ~ 15 parts, pelargonium 10 ~ 15 parts.

4. the preparation method of Chinese medicine expelling parasite additive according to any one of claims 1 to 3, it is characterized in that, the preparation method of described Chinese medicine expelling parasite additive comprises the following steps:

A. get all bulk drug way of distillations and be vaporized into crystallization, pulverize dusting cover stand-by, as component 1;

B. distillation test residue ethanol heat is extracted 2 times, merge concentrated extracting solution, as component 2;

E. mix well after component 1 being mixed with component 2, sterilization tinning is stand-by.

5. the preparation method of Chinese medicine expelling parasite additive according to claim 4, is characterized in that, in described step a, first distilled by all bulk drug steam methods, obtain crystal, then pulverize, and crosses 120-150 mesh sieve, for subsequent use as component 1.

6. the preparation method of Chinese medicine expelling parasite additive according to claim 4, is characterized in that, in described step b, the residue of the bulk drug that the way of distillation was extracted, add the alcohol immersion 4-6 hour accounting for its quality 5-10 times amount, heating extraction 2 times, each 1-2 hour, merge extract, remove supernatant after leaving standstill, then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.25 filtrate, as component 2.

7. the preparation method of Chinese medicine expelling parasite additive according to claim 4, is characterized in that, in described step c, be mixed into by the powder crystallization of pulverizing in the filtrate of component 2, stand-by after ultraviolet radiation for sterilizing and disinfecting.

8. a peppermint underwear fabric, is characterized in that, the raw materials of described underwear fabric comprises: mint fibers and the Chinese medicine expelling parasite additive according to any one of claim 1-3.

9. peppermint underwear fabric according to claim 8, it is characterized in that, the preparation method of described underwear fabric comprises the following steps:

A. the purification step of mint fibers;

B. cellulosic activation step;

C. cellulose is at the dissolving step of copper ammon solution;

D. the step of spinning.

10. peppermint underwear fabric according to claim 8, it is characterized in that, the step of described d. spinning comprises further: the preparation of spinning solution, filtration, deaeration, regeneration, pickling, washing, hot gas spring.