CN105832991A - Traditional Chinese medicine composition for treating gastritis - Google Patents
Traditional Chinese medicine composition for treating gastritis Download PDFInfo
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- CN105832991A CN105832991A CN201610181847.3A CN201610181847A CN105832991A CN 105832991 A CN105832991 A CN 105832991A CN 201610181847 A CN201610181847 A CN 201610181847A CN 105832991 A CN105832991 A CN 105832991A
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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Abstract
The invention provides a traditional Chinese medicine composition for treating gastritis, which includes the following raw material medicines, by weight: 5-20 parts of radix bupleuri, 5-20 parts of fructus aurantii, 5-30 parts of white peony roots, 5-20 parts of rhizoma cyperi, 5-20 parts of raw radix glycyrrhizae, 5-20 parts of honey-fried radix glycyrrhizae, 5-20 parts of cuttlebone, 5-20 parts of fritillaria thunbergii, 5-20 parts of dandelion, 3-30 parts of coptis chinensis, 1-10 parts of fructus evodiae and 5-20 parts of eupatorium fortunei, and also can include one or any more than one from scutellaria baicalensis, rhizoma pinellinae praeparata, poria cocos, scorched medicated leaven, scorched hawthorns, agastache rugosus, sichuan fritillary bulb and galangal. The traditional Chinese medicine composition has definite curative effects on acute and chronic gastritis caused by all reasons.
Description
Technical field
The invention belongs to tcm field, be specifically related to a kind of Chinese medicine composition that gastritis is had definite curative effect
Thing.
Background technology
Gastritis is one of modal digestive system disease, be often accompanied by epithelial damage, mucosal inflammation reaction and
Epithelium regeneration.By emergency and the course of disease length of clinical onset, typically gastritis is divided into acute gastritis and chronic
Gastritis.The former is the Acute Gastric Mucosal inflammation caused by Different types of etiopathogenises；The most often show as epigastrium not
The symptoms such as suitable, dull pain, Nausea and vomiting.Chronic gastritis is the gastric mucosa chronic inflammation caused by the various causes of disease
Disease or atrophic lesion, be divided into again superficial gastritis, atrophic gastritis, bile reflux gastritis etc..Should
Sick medical history is long, easy recurrent exerbation, it is difficult to radical cure；Clinically show as upper abdominal pain, abdominal distention, belch,
Inappetence, acid regurgitation, weak, constipation or diarrhoea, then gastric mucosa degeneration atrophy for a long time, stomachial secretion function
Decline and cause patient's emaciated physique, immunity degradation, even produce gastric mucosa and cancerate.Sending out of chronic gastritis
Raw, development and emotion, pressure, life style are closely related.Along with rhythm of life quickening, life stress
Strengthening, the sickness rate of chronic gastritis remains high, and greatly endangers population health, increases medical burden.
The most typically use gastric mucosa protectant, antacid, gastrointestinal motility function regulator at present, resist
The symptomatic treatment medicines such as raw element, need to take medicine continuously one to two months.Antacid is the most frequently used medicine,
Although it can alleviate the gastric acid further stimulation to impaired gastric mucosa, alleviate stomachache；But subtract the most simultaneously
Lack food digesting and assimilating in stomach.
Gastritis, especially chronic gastritis belong to the disease scopes such as the traditional Chinese medical science " gastric abscess " " stomach syndrome of feeling fullness and distension in the upper abdomen ".The traditional Chinese medical science is recognized
For, chronic gastritis many because of long-term feelings will unsuccessful, eating and drinking without temperance, work and rest is not normal, causes depression of liver-QI, and spleen loses
Being good for fortune, gastral cavilty is become estranged, with the passing of time middle gas virtual loss, thus causes all symptoms.Chronic Gastritis Clinic Cured by Chinese Medicine obtains
Preferable effect.As, Guo Chunsheng Banxia Xiexin Decoction Plus-minus, treat 100 example Patients with Chronic Gastritis, right
According to organizing 50 example pill of costus and amomum with six noble ingredients, it it within 1 month, it is 1 course for the treatment of.Result: treatment group and matched group effective percentage
Respectively 92% and 76% (P ＜ 0.05) (Guo Chunsheng. banxia xiexin decoction treatment chronic gastritis 100 example is faced
Bed observes [J]. traditional Chinese medical science forum, and 2006,21 (5): 7).
Although occurring in that multiple with gastritis in prior art, the most various chronic gastritiss are the medicine of indication,
Including Chinese patent medicine, but the sickness rate of China's chronic gastritis is still up to 30% according to statistics, and existing medicine is described
Still the Treatment need of clinic can not be met.
Summary of the invention
In order to overcome the deficiencies in the prior art, the invention provides a kind of to gastritis, the most various chronic
Gastritis has the Chinese medicine composition of significant curative effect.Pathogenesis for gastritis: irritability is retarded by silt, dysfunction of the spleen in transportation, stomach
Becoming estranged fall, the Chinese medicine compound of the present invention is main method for the treatment of with " liver-smoothing, qi-regulating ", " invigorating the spleen and regulating the stomach ", prescription
Rationally, essence want, acute or chronic gastritis has definite curative effect by clinical practice, onset in general 3～5 days,
Within 5～10 days, effect is notable, and relapse rate is low.
In order to realize foregoing invention purpose, present invention employs following technical scheme:
A kind of Chinese medicine composition treating gastritis, raw material includes the medical material of following weight portion:
Radix Bupleuri 5～20 weight portion, Fructus Aurantii 5～20 weight portion, the Radix Paeoniae Alba 5～30 weight portion, Rhizoma Cyperi 5～20 weight
Amount part, Radix Glycyrrhizae 5～20 weight portion, Radix Glycyrrhizae Preparata 5～20 weight portion, Endoconcha Sepiae 5～20 weight portion, Bulbus Fritillariae Thunbergii
5～20 weight portions, Herba Taraxaci 5～20 weight portion, Rhizoma Coptidis 3～30 weight portion, Fructus Evodiae 1～10 weight portion,
Herba Eupatorii 5～20 weight portion.
Preferably, described Chinese medicine composition, raw material includes the medical material of following weight portion:
Radix Bupleuri 10～20 weight portion, Fructus Aurantii 10～20 weight portion, the Radix Paeoniae Alba 10～30 weight portion, Rhizoma Cyperi 10～20
Weight portion, Radix Glycyrrhizae 10～20 weight portion, Radix Glycyrrhizae Preparata 10～20 weight portion, Endoconcha Sepiae 10～20 weight portion,
Bulbus Fritillariae Thunbergii 10～20 weight portion, Herba Taraxaci 10～20 weight portion, Rhizoma Coptidis 5～15 weight portion, Fructus Evodiae 1～5 weight
Amount part, Herba Eupatorii 10～20 weight portion.
Preferably, above-mentioned Chinese medicine composition, the Fructus Aurantii in raw material, Rhizoma Cyperi, Radix Glycyrrhizae, Radix Glycyrrhizae Preparata, sea
The egg capsule of a mantis, Bulbus Fritillariae Thunbergii, Herba Taraxaci weight portion identical.
Preferably, above-mentioned Chinese medicine composition, Rhizoma Coptidis and the weight portion of Fructus Evodiae in raw material are less than other medicine
The weight portion of material；Particularly, the weight portion of Fructus Evodiae is minimum.
In order to heighten the effect of a treatment, described Chinese medicine composition, raw material also include selected from Radix Scutellariae, Rhizoma Pinelliae Preparatum, Poria,
A kind of or the most multiple in Massa Medicata Fermentata (parched to brown), Fructus Crataegi (parched to brown), Fructus Hordei Germinatus (parched to brown), Herba Pogostemonis, Bulbus Fritillariae Cirrhosae, Rhizoma Alpiniae Officinarum.
As one preferred embodiment, a kind of Chinese medicine composition treating gastritis that the present invention provides,
Raw material consists of:
Radix Bupleuri 5～20 weight portion, Fructus Aurantii 5～20 weight portion, the Radix Paeoniae Alba 5～30 weight portion, Rhizoma Cyperi 5～20 weight
Amount part, Radix Glycyrrhizae 5～20 weight portion, Radix Glycyrrhizae Preparata 5～20 weight portion, Endoconcha Sepiae 5～20 weight portion, Bulbus Fritillariae Thunbergii
5～20 weight portions, Herba Taraxaci 5～20 weight portion, Rhizoma Coptidis 3～30 weight portion, Fructus Evodiae 1～10 weight portion,
Herba Eupatorii 5～20 weight portion, Radix Scutellariae 5～20 weight portion, Rhizoma Pinelliae Preparatum 5～20 weight portion, Poria 5～30 weight portion,
Massa Medicata Fermentata (parched to brown) 5～30 weight portion, Fructus Crataegi (parched to brown) 5～30 weight portion, Fructus Hordei Germinatus (parched to brown) 5～30 weight portion, Herba Pogostemonis 5～20 weight
Amount part, Bulbus Fritillariae Cirrhosae 3～15 weight portion, Rhizoma Alpiniae Officinarum 3～15 weight portion.
As a preferred embodiment, a kind of Chinese medicine composition treating gastritis that the present invention provides,
Raw material consists of:
Radix Bupleuri 10～20 weight portion, Fructus Aurantii 10～20 weight portion, the Radix Paeoniae Alba 10～30 weight portion, Rhizoma Cyperi 10～20
Weight portion, Radix Glycyrrhizae 10～20 weight portion, Radix Glycyrrhizae Preparata 10～20 weight portion, Endoconcha Sepiae 10～20 weight portion,
Bulbus Fritillariae Thunbergii 10～20 weight portion, Herba Taraxaci 10～20 weight portion, Rhizoma Coptidis 5～15 weight portion, Fructus Evodiae 1～5 weight
Amount part, Herba Eupatorii 10～20 weight portion, Radix Scutellariae 10～20 weight portion, Rhizoma Pinelliae Preparatum 9～20 weight portion, Poria 10～30
Weight portion, Massa Medicata Fermentata (parched to brown) 10～30 weight portion, Fructus Crataegi (parched to brown) 10～30 weight portion, Fructus Hordei Germinatus (parched to brown) 10～30 weight portion,
Herba Pogostemonis 10～30 weight portion, Bulbus Fritillariae Cirrhosae 5～15 weight portion, Rhizoma Alpiniae Officinarum 5～15 weight portion.
Above-mentioned preferred Chinese medicine composition, the Fructus Aurantii in raw material, Rhizoma Cyperi, Radix Glycyrrhizae, Radix Glycyrrhizae Preparata, sea Piao
Octopus ocellatus Gray, Bulbus Fritillariae Thunbergii, Herba Taraxaci weight portion identical.
Above-mentioned preferred Chinese medicine composition, the Rhizoma Coptidis in raw material, Fructus Evodiae, Bulbus Fritillariae Cirrhosae, the weight of Rhizoma Pinelliae Preparatum
Part is less than the weight portion of other medical material；Particularly, the weight portion of Fructus Evodiae is minimum.
As most preferred embodiment, a kind of Chinese medicine composition treating gastritis that the present invention provides, former
Material consists of:
Radix Bupleuri 10 weight portion, Fructus Aurantii 10 weight portion, the Radix Paeoniae Alba 15 weight portion, Rhizoma Cyperi 10 weight portion, life
Radix Glycyrrhizae 10 weight portion, Radix Glycyrrhizae Preparata 10 weight portion, Endoconcha Sepiae 10 weight portion, Bulbus Fritillariae Thunbergii 10 weight portion, Pu
Herba Taraxaci 10 weight portion, Rhizoma Coptidis 6 weight portion, Fructus Evodiae 2 weight portion, Herba Eupatorii 10 weight portion, Radix Scutellariae 10 weight
Amount part, Rhizoma Pinelliae Preparatum 9 weight portion, Poria 15 weight portion, Massa Medicata Fermentata (parched to brown) 15 weight portion, Fructus Crataegi (parched to brown) 15 weight portion,
Fructus Hordei Germinatus (parched to brown) 15 weight portion, Herba Pogostemonis 10 weight portion, Bulbus Fritillariae Cirrhosae 6 weight portion, Rhizoma Alpiniae Officinarum 6 weight portion.
It is a further object of the invention to provide the preparation method of above-mentioned Chinese medicine composition, including walking as follows
Rapid:
By the raw material of described weight portion, directly pulverize or through water or the extraction with aqueous solution of ethanol, add or not
Add pharmaceutically acceptable adjuvant, according to this area conventional method, make acceptable system clinically
Agent.
The described preparation of acceptable clinically is preferably oral formulations, more preferably water decoction, oral liquid,
Honey pill agent, watered pill, concentrated pill, capsule or tablet.
The present invention also provides for the medicine prepared by above-mentioned preparation method.
It is a further object of the invention to provide above-mentioned Chinese medicine composition, or be prepared by above-mentioned preparation method
The medicine obtained application in the medicine of preparation treatment gastritis.
Described gastritis includes acute gastritis and chronic gastritis；Wherein, chronic gastritis includes superficial gastritis, slow
Property erosive gastritis and atrophic gastritis.
" weight portion " of the present invention, expression is that in described Chinese medicine composition, the consumption proportion of each raw material is correlated with.
According to practical situations, " 1 weight portion " of the present invention can be " 1 gram ", " 1kg " or other is any
Weight.
In the preparation method of Chinese medicine composition of the present invention, if no special instructions, water or ethanol water
Consumption is the conventional amount used of this area.
Chinese medicine composition of the present invention, the acute gastritis, the chronic gastritis that cause a variety of causes have really
The curative effect cut, typically gives Chinese medicine composition of the present invention 3 days, the abdominal distention of patient, stomachache, abdomen
Rush down, Nausea and vomiting, singultus, return acid etc. symptom the most substantially alleviate, within 5～10 days, above-mentioned symptom disappears substantially；
And patient take medicine before sign, as wax yellow in complexion or dark yellow, figure becomes thin etc. also has clear improvement, and says
The function of bright patient's transporting and transforming function of the spleen and stomach essence of water and grain is restored, and body can be nourished again, thus improves trouble
Person's body constitution.
Detailed description of the invention
Referring to specific embodiment the present invention made and further illustrating.Those skilled in the art can manage
Solving, these embodiments are merely to illustrate the present invention, and it limits the scope of the present invention never in any form.Following
Experimental technique in embodiment, if no special instructions, is conventional method.Used by following embodiment
Medicinal raw material, reagent material etc., if no special instructions, be commercially available purchase product.
Embodiment 1A kind of Chinese medicine composition treating gastritis
Raw material consists of: (unit: g；1g=1 weight portion)
Radix Bupleuri 10, Fructus Aurantii 10, the Radix Paeoniae Alba 15, Rhizoma Cyperi 10, Radix Glycyrrhizae 10, Radix Glycyrrhizae Preparata 10, Endoconcha Sepiae 10,
Bulbus Fritillariae Thunbergii 10, Herba Taraxaci 10, Rhizoma Coptidis 6, Fructus Evodiae 2, Herba Eupatorii 10.
Embodiment 2A kind of Chinese medicine composition treating gastritis
Raw material consists of: (unit: g；1g=1 weight portion)
Radix Bupleuri 20, Fructus Aurantii 15, the Radix Paeoniae Alba 20, Rhizoma Cyperi 15, Radix Glycyrrhizae 15, Radix Glycyrrhizae Preparata 15, Endoconcha Sepiae 15,
Bulbus Fritillariae Thunbergii 15, Herba Taraxaci 15, Rhizoma Coptidis 10, Fructus Evodiae 5, Herba Eupatorii 20.
Embodiment 3A kind of Chinese medicine composition treating gastritis
Raw material consists of: (unit: g；10g=1 weight portion)
Radix Bupleuri 50, Fructus Aurantii 50, the Radix Paeoniae Alba 100, Rhizoma Cyperi 50, Radix Glycyrrhizae 50, Radix Glycyrrhizae Preparata 50, Endoconcha Sepiae
50, Bulbus Fritillariae Thunbergii 50, Herba Taraxaci 50, Rhizoma Coptidis 50, Fructus Evodiae 10, Herba Eupatorii 100.
Embodiment 4A kind of Chinese medicine composition treating gastritis
Raw material consists of: (unit: kg；1kg=1 weight portion)
Radix Bupleuri 20, Fructus Aurantii 10, the Radix Paeoniae Alba 15, Rhizoma Cyperi 10, Radix Glycyrrhizae 10, Radix Glycyrrhizae Preparata 10, Endoconcha Sepiae 10,
Bulbus Fritillariae Thunbergii 10, Herba Taraxaci 10, Rhizoma Coptidis 9, Fructus Evodiae 3, Herba Eupatorii 10.
Embodiment 5A kind of Chinese medicine composition treating gastritis
Raw material consists of: (unit: g；1g=1 weight portion)
Radix Bupleuri 10, Fructus Aurantii 10, the Radix Paeoniae Alba 15, Rhizoma Cyperi 10, Radix Glycyrrhizae 10, Radix Glycyrrhizae Preparata 10, Endoconcha Sepiae 10,
Bulbus Fritillariae Thunbergii 10, Herba Taraxaci 10, Radix Scutellariae 10, Rhizoma Pinelliae Preparatum 9, Rhizoma Coptidis 6, Fructus Evodiae 2, Poria 15, Herba Eupatorii 10,
Massa Medicata Fermentata (parched to brown) 15, Fructus Crataegi (parched to brown) 15, Fructus Hordei Germinatus (parched to brown) 15, Herba Pogostemonis 10, Bulbus Fritillariae Cirrhosae 6, Rhizoma Alpiniae Officinarum 6.
Embodiment 6A kind of Chinese medicine composition treating gastritis
Raw material consists of: (unit: g；1g=1 weight portion)
Radix Bupleuri 15, Fructus Aurantii 15, the Radix Paeoniae Alba 20, Rhizoma Cyperi 15, Radix Glycyrrhizae 15, Radix Glycyrrhizae Preparata 15, Endoconcha Sepiae 15,
Bulbus Fritillariae Thunbergii 15, Herba Taraxaci 15, Radix Scutellariae 10, Rhizoma Pinelliae Preparatum 6, Rhizoma Coptidis 6, Fructus Evodiae 2, Massa Medicata Fermentata (parched to brown) 10, Jiaoshan Hill
Short, bristly hair or beard 10, Fructus Hordei Germinatus (parched to brown) 10, Herba Pogostemonis 10, Rhizoma Alpiniae Officinarum 6.
Embodiment 7A kind of Chinese medicine composition treating gastritis
Raw material consists of: (unit: g；1g=1 weight portion)
Radix Bupleuri 20, Fructus Aurantii 10, the Radix Paeoniae Alba 15, Rhizoma Cyperi 10, Radix Glycyrrhizae 10, Radix Glycyrrhizae Preparata 10, Endoconcha Sepiae 10,
Bulbus Fritillariae Thunbergii 10, Herba Taraxaci 10, Radix Scutellariae 10, Rhizoma Coptidis 9, Fructus Evodiae 2, Poria 10, Herba Eupatorii 10, Massa Medicata Fermentata (parched to brown)
15, Fructus Crataegi (parched to brown) 15, Fructus Hordei Germinatus (parched to brown) 15, Rhizoma Alpiniae Officinarum 10.
Embodiment 8A kind of Chinese medicine composition treating gastritis
Raw material consists of: (unit: kg；1kg=1 weight portion)
Radix Bupleuri 20, Fructus Aurantii 15, the Radix Paeoniae Alba 30, Rhizoma Cyperi 15, Radix Glycyrrhizae 15, Radix Glycyrrhizae Preparata 15, Endoconcha Sepiae 15,
Bulbus Fritillariae Thunbergii 15, Herba Taraxaci 15, Radix Scutellariae 10, Rhizoma Pinelliae Preparatum 9, Rhizoma Coptidis 6, Fructus Evodiae 2, Poria 10, Herba Eupatorii 10,
Massa Medicata Fermentata (parched to brown) 15, Fructus Crataegi (parched to brown) 15, Fructus Hordei Germinatus (parched to brown) 15, Herba Pogostemonis 10, Bulbus Fritillariae Cirrhosae 6, Rhizoma Alpiniae Officinarum 6.
Embodiment 9A kind of Chinese medicine composition (water decoction) treating gastritis
Form according to the raw material of embodiment 1 and prepare ingredients, boiling twice, each 30～40 minutes,
Consumption is medical material gross weight 5～8 times of water, merge twice decocting liquid, to obtain final product every time.
Consumption usage: in one day, medicinal liquid is taken down at twice.
Embodiment 10A kind of Chinese medicine composition (water decoction) treating gastritis
Form according to the raw material of embodiment 5 and prepare ingredients, boiling twice, each 30～40 minutes,
Consumption is medical material gross weight 5～8 times of water, merge twice decocting liquid, to obtain final product every time.
Consumption usage: in one day, medicinal liquid is taken down at twice.
Embodiment 11A kind of Chinese medicine composition (concentrated pill) treating gastritis
Form according to the raw material of embodiment 8 and prepare ingredients；Endoconcha Sepiae, the Radix Paeoniae Alba, Poria, Bulbus Fritillariae Thunbergii and river
Shellfish pulverized 100 mesh sieves respectively, standby；Other ingredients boiling twice, each 60 minutes, often
The consumption of secondary water is 8～10 times of medical material gross weight, merges twice decocting liquid；Decocting liquid is concentrated into thick paste, adds
Enter Endoconcha Sepiae, Bulbus Fritillariae Thunbergii and Bulbus Fritillariae Cirrhosae powder, mix homogeneously, general ball of making, bottling, 200 balls/bottle.
Consumption usage: oral, one time 10～20 balls, every day twice.
Embodiment 12A kind of Chinese medicine composition (honey pill agent) treating gastritis
Form according to the raw material of embodiment 4 and prepare ingredients, pulverized 80 mesh sieves respectively, mix homogeneously,
Add refined honey (weight ratio, medicated powder: refined honey=1:1), make big honeyed pills, 6g/ ball.
Consumption usage: oral, a ball, every day twice.
Embodiment 13A kind of Chinese medicine composition (tablet or capsule) treating gastritis
Form according to the raw material of embodiment 7 and the ratio of 1 weight portion=1kg prepares ingredients；Endoconcha Sepiae
Pulverized 100 mesh sieves, standby；The ethanol solution heating extraction of remaining each taste concentration of volume percent 50%
Twice, each 1.5 hours, each ethanol solution consumption was extract medical material gross weight 6～8 times, merges twice
Extracting solution, reclaims ethanol, is concentrated into the clear paste of 60 DEG C of density 1.2～1.4g/ml, adds Endoconcha Sepiae powder, mixing
Uniformly, dry, pulverize, add appropriate amount of starch, pelletize, tabletting or encapsulated.
Consumption usage: twice on the one, each 3～4 or 3～4 capsules.
Embodiment 14A kind of Chinese medicine composition (oral liquid or syrup) treating gastritis
Form according to the raw material of embodiment 7 and the ratio of 1 weight portion=1kg prepares ingredients；Use decocting
Boiling 2 times, each 1 hour, each water consumption is 8 times of medical material gross weight, merges decocting liquid；Add second
Alcohol, to concentration of alcohol 50%, stands, leaching supernatant, and recovery ethanol, to without alcohol taste, is concentrated into 60 DEG C of density
It is the clear paste of 1.2～1.4g/ml, adds odor mask, make oral liquid or syrup.
Consumption usage, twice on the one, each 10ml.
Clinical observation example 1The clinical effectiveness of the traditional Chinese medicine composition for treating chronic gastritis of the present invention
1. physical data
Gate of Pervasive Peace institute of traditional Chinese medicine of department of Chinese medicine institute of China Digestive System Department outpatient service Patients with Chronic Gastritis 100 example, divides at random
It is 2 groups, treatment group 50 example, matched group 50 example.
Difference on the not statistically significants such as the age of two groups of patients, sex, the course of disease, has comparability.
2. diagnostic criteria
According to Ministry of Public Health " new Chinese medicine guideline of clinical investigations " and State Administration of Traditional Chinese Medicine " in cure the desease
Card Standardization of diagnosis and curative effect " formulate.
Inclusive criteria: 1. endoscopy meets chronic gastritis diagnostic criteria；2. have gastralgia, flatulence,
Returning acid, poor appetite, loose stool, the symptom such as weak, tongue is the most greasy, stringy pulse；The course of disease is more than 2 months.
Exclusion standard: the 1. few tongue of red tongue or red tongue with yellow fur person；2. merge peptic ulcer or be suspected to have the person of cancerating；
It is associated with other system serious disease person the most simultaneously；4. have complication to affect the treatment to observe or to trial drug
There is taboo person.
3. criterion of therapeutical effect
With " without, light, in, weight " note " 0,1,2,3 points " respectively, to the gastralgia of patient, flatulence,
Return acid, poor appetite, loose stool, the symptom such as weak are given a mark the most respectively, add up to overall score.
Calculate overall score down ratio after treatment according to the following formula.
Overall score × 100% before overall score down ratio=(overall score after overall score-treatment before treatment)/treatment
According to overall score down ratio, in conjunction with gastroscopy result, curative effect is divided into Short Term Clinical cure, shows
Effect, effective and invalid:
Short Term Clinical is cured: clinical cardinal symptom overall score down ratio >=75%, gastroscopy activity after treatment
Property inflammation disappear, chronic inflammatory disease takes a turn for the better, and pathologic finding confirms that gastroscope finding body of gland atrophy recovers normal or disappears.
Effective: clinical cardinal symptom overall score down ratio >=55% after 75% ＞ treatment, gastroscopy mucosa is anxious
Property inflammation substantially disappear, chronic inflammatory disease takes a turn for the better, and pathologic finding confirms gastroscope finding body of gland atrophy, intestinal or not
Typical case's hypertrophy alleviates.
Effective: clinical cardinal symptom overall score down ratio >=40% after 55% ＞ treatment, gastroscopy mucosal disease
Becoming range shorter more than 1/2, inflammation has alleviated, and pathologic finding confirms that gastroscope finding inflammation subtracts inflammation, body of gland
Atrophy, intestinal or atypical hyperplasia alleviate.
Invalid: clinical cardinal symptom overall score down ratio ＜ 40% after treatment, or symptom deteriorated.
4. Therapeutic Method
Treatment group: the Chinese medicine composition water decoction of embodiment 10 preparation, under one takes at twice, 5 days is one
The individual course for the treatment of, treat a course for the treatment of.
Matched group: Rhizoma Pinelliae 10g, Radix Scutellariae 10g, Rhizoma Coptidis 6g, Rhizoma Zingiberis 10g, Radix Codonopsis 15g, Radix Glycyrrhizae 6g,
Fructus Jujubae 10g (banxia xiexin decoction)；Water decoction is prepared according to the method for embodiment 10, under one takes at twice,
Within 5 days, it is a course for the treatment of, treats a course for the treatment of.
5. result of the test
During treatment, all do not observe side effect for two groups.The clinical efficacy correction data for the treatment of group and matched group,
It is shown in Table 1.
Table 1 treatment group and the contrast of matched group clinical efficacy
It is right that treatment group is all significantly better than in terms of average score down ratio, the healing index such as number, total effective rate
According to group, illustrate that the Chinese medicine composition of the present invention has more preferable therapeutical effect to chronic gastritis.
6. model case
1) treatment group
1. Dong's ××, man, 48 years old；It is diagnosed as chronic erosive gastritis, the course of disease 3 years through gastroscopy；Warp
Cross a course of therapy, reach Short Term Clinical and cure.Taking medicine the most continuously a course for the treatment of, sign has obtained greatly
Ground improves.Before and after treatment, every sings and symptoms scoring situation, is shown in Table 2.
Table 2 patients symptomatic's sign grade form (1)
2. shut out ××, female, 37 years old；It is diagnosed as chronic gastritis, the course of disease 2.5 years through gastroscopy；Through one
Individual course of therapy, reaches Short Term Clinical and cures.Taking medicine the most continuously a course for the treatment of, sign has obtained greatly changing
Kind.Before and after treatment, every sings and symptoms scoring situation, is shown in Table 3.
Table 3 patients symptomatic's sign grade form (2)
3. Lee's ××, man, 43 years old；It is diagnosed as chronic gastritis, the course of disease 1.5 years through gastroscopy；Through one
Individual course of therapy, reaches Short Term Clinical and cures.Taking medicine the most continuously a course for the treatment of, sign has obtained greatly changing
Kind.Before and after treatment, every sings and symptoms scoring situation, is shown in Table 4.
Table 4 patients symptomatic's sign grade form (3)
2) matched group
1. ×× is opened, man, 44 years old, it is diagnosed as chronic gastritis, the course of disease 2 years through gastroscopy；Through one
Course of therapy, reaches Short Term Clinical and cures.Taking medicine the most continuously a course for the treatment of, sign obtains part and improves.Control
Before and after treatment, every sings and symptoms scoring situation, is shown in Table 5.
Table 5 patients symptomatic's sign grade form (4)
2. ×× is opened, man, 44 years old, it is diagnosed as chronic erosive gastritis, the course of disease 1.5 years through gastroscopy；
Through a course of therapy, reach Short Term Clinical and cure.Taking medicine the most continuously a course for the treatment of, sign obtains part
Improve.Before and after treatment, every sings and symptoms scoring situation, is shown in Table 6.
Table 6 patients symptomatic's sign grade form (5)
Clinical observation example 2The clinical effectiveness of the traditional Chinese medicine composition for treating acute gastritis of the present invention
The water decoction treatment that the Digestive System Department outpatient service of Gate of Pervasive Peace institute of traditional Chinese medicine of department of Chinese medicine institute of China is prepared by embodiment 10
Acute gastritis patient 80 example, patient all causes to feel sick, vomit because of reasons such as intemperance of taking food or chronic gastritis acute attacks
Tell, upper abdominal pain, onset is anxious, gets rid of bacillary gastroenteritis and gastrointestinal reaction that Other diseases causes.With " without,
Gently, in, weight " note " 0,1,2,3 points " respectively, to the stomachache of patient, nausea,vomiting,diarrhea, weary
The symptoms such as power are given a mark the most respectively, add up to overall score.
All patients each item rating before medication is all that 2-3 divides, and total score 12-15 is divided；Medication 3 days, symptom is bright
Showing and alleviate, each item rating is reduced to 1-2 and is divided, and total score 4-9 is divided；After 5 days, symptom disappears substantially, and each item rating drops
For 0-1, total score 0-2.
By observing the clinical application of above-mentioned patient, acute gastritis is also had non-by the Chinese medicine composition of the present invention
The most significantly curative effect.
It is as follows that part represents case:
The oldest ××, man, 50 years old, because of stomachache, Nausea and vomiting, weak, diarrhoea 1 day go to a doctor, excrement inspection
Getting rid of bacillary gastroenteritis, give the water decoction of embodiment 10 preparation, within 3 days, symptom substantially alleviates, and within 5 days, removes
Sensation is slight feel sick outside, other symptom all disappears.Every sings and symptoms scoring situation, is shown in Table 7.
Table 7 patients symptomatic's sign grade form (6)
| Symptom | Before treatment | Treat 3 days | Treat 5 days | Sign | Before treatment | Treat 5 days | Treat 10 days |
| Diarrhoea | 3 | 1 | 0 | Complexion is dark yellow | 3 | 2 | 0 |
| Feel sick | 3 | 2 | 1 | Dehydration face | 3 | 1 | 0 |
| Vomiting | 3 | 1 | 0 | ||||
| Stomachache | 3 | 0 | 0 | ||||
| Total score | 12 | 4 | 1 | Total score | 6 | 3 | 0 |
2. yellow ×, man, 43 years old, because stomachache, Nausea and vomiting, weak, diarrhoea are gone to a doctor for 2 days, excrement inspection was arranged
Except bacillary gastroenteritis, giving the water decoction of embodiment 10 preparation, within 3 days, symptom has alleviated, 5 days except
Outside the slight stomachache of sensation, other symptom all disappears.Every sings and symptoms scoring situation, is shown in Table 8.
Table 8 patients symptomatic's sign grade form (7)
| Symptom | Before treatment | Treat 3 days | Treat 5 days | Sign | Before treatment | Treat 5 days | Treat 10 days |
| Diarrhoea | 3 | 2 | 0 | The cured Huang of complexion | 3 | 2 | 0 |
| Feel sick | 3 | 2 | 0 | Dehydration face | 3 | 2 | 0 |
| Vomiting | 3 | 1 | 0 | ||||
| Stomachache | 3 | 1 | 1 | ||||
| Total score | 12 | 6 | 1 | Total score | 6 | 4 | 0 |
Claims (10)
1. treating a Chinese medicine composition for gastritis, raw material includes the medical material of following weight portion:
Radix Bupleuri 5～20 weight portion, Fructus Aurantii 5～20 weight portion, the Radix Paeoniae Alba 5～30 weight portion, Rhizoma Cyperi 5～20
Weight portion, Radix Glycyrrhizae 5～20 weight portion, Radix Glycyrrhizae Preparata 5～20 weight portion, Endoconcha Sepiae 5～20 weight portion,
Bulbus Fritillariae Thunbergii 5～20 weight portion, Herba Taraxaci 5～20 weight portion, Rhizoma Coptidis 3～30 weight portion, Fructus Evodiae 1～10
Weight portion, Herba Eupatorii 5～20 weight portion；
Preferably, described Chinese medicine composition, raw material includes the medical material of following weight portion:
Radix Bupleuri 10～20 weight portion, Fructus Aurantii 10～20 weight portion, the Radix Paeoniae Alba 10～30 weight portion, Rhizoma Cyperi 10～20
Weight portion, Radix Glycyrrhizae 10～20 weight portion, Radix Glycyrrhizae Preparata 10～20 weight portion, Endoconcha Sepiae 10～20 weight
Part, Bulbus Fritillariae Thunbergii 10～20 weight portion, Herba Taraxaci 10～20 weight portion, Rhizoma Coptidis 5～15 weight portion, Fructus Evodiae
1～5 weight portions, Herba Eupatorii 10～20 weight portion.
Chinese medicine composition the most according to claim 1, it is characterised in that described Chinese medicine composition,
Fructus Aurantii in raw material, Rhizoma Cyperi, Radix Glycyrrhizae, Radix Glycyrrhizae Preparata, Endoconcha Sepiae, Bulbus Fritillariae Thunbergii, the weight portion of Herba Taraxaci
Identical；
It is also preferred that the weight portion of Rhizoma Coptidis in raw material and Fructus Evodiae is less than the weight portion of other medical material；
Particularly, the weight portion of Fructus Evodiae is minimum.
Chinese medicine composition the most according to claim 1 and 2, it is characterised in that raw material also includes choosing
In Radix Scutellariae, Rhizoma Pinelliae Preparatum, Poria, Massa Medicata Fermentata (parched to brown), Fructus Crataegi (parched to brown), Fructus Hordei Germinatus (parched to brown), Herba Pogostemonis, Bulbus Fritillariae Cirrhosae, Rhizoma Alpiniae Officinarum
A kind of or the most multiple.
4. treating a Chinese medicine composition for gastritis, raw material consists of:
Radix Bupleuri 5～20 weight portion, Fructus Aurantii 5～20 weight portion, the Radix Paeoniae Alba 5～30 weight portion, Rhizoma Cyperi 5～20
Weight portion, Radix Glycyrrhizae 5～20 weight portion, Radix Glycyrrhizae Preparata 5～20 weight portion, Endoconcha Sepiae 5～20 weight portion,
Bulbus Fritillariae Thunbergii 5～20 weight portion, Herba Taraxaci 5～20 weight portion, Rhizoma Coptidis 3～30 weight portion, Fructus Evodiae 1～10
Weight portion, Herba Eupatorii 5～20 weight portion, Radix Scutellariae 5～20 weight portion, Rhizoma Pinelliae Preparatum 5～20 weight portion, Poria
5～30 weight portions, Massa Medicata Fermentata (parched to brown) 5～30 weight portion, Fructus Crataegi (parched to brown) 5～30 weight portion, Fructus Hordei Germinatus (parched to brown) 5～30 weight
Part, Herba Pogostemonis 5～20 weight portion, Bulbus Fritillariae Cirrhosae 3～15 weight portion, Rhizoma Alpiniae Officinarum 3～15 weight portion.
5. treating a Chinese medicine composition for gastritis, raw material consists of:
Radix Bupleuri 10～20 weight portion, Fructus Aurantii 10～20 weight portion, the Radix Paeoniae Alba 10～30 weight portion, Rhizoma Cyperi 10～20
Weight portion, Radix Glycyrrhizae 10～20 weight portion, Radix Glycyrrhizae Preparata 10～20 weight portion, Endoconcha Sepiae 10～20 weight
Part, Bulbus Fritillariae Thunbergii 10～20 weight portion, Herba Taraxaci 10～20 weight portion, Rhizoma Coptidis 5～15 weight portion, Fructus Evodiae
1～5 weight portions, Herba Eupatorii 10～20 weight portion, Radix Scutellariae 10～20 weight portion, Rhizoma Pinelliae Preparatum 9～20 weight portion,
Poria 10～30 weight portion, Massa Medicata Fermentata (parched to brown) 10～30 weight portion, Fructus Crataegi (parched to brown) 10～30 weight portion, Fructus Hordei Germinatus (parched to brown)
10～30 weight portions, Herba Pogostemonis 10～30 weight portion, Bulbus Fritillariae Cirrhosae 5～15 weight portion, Rhizoma Alpiniae Officinarum 5～15 weight portion.
6. according to the Chinese medicine composition according to any one of claim 4 or 5, it is characterised in that former
Fructus Aurantii in material, Rhizoma Cyperi, Radix Glycyrrhizae, Radix Glycyrrhizae Preparata, Endoconcha Sepiae, Bulbus Fritillariae Thunbergii, the weight portion phase of Herba Taraxaci
With；
Preferably, described Chinese medicine composition, Rhizoma Coptidis in raw material, Fructus Evodiae, Bulbus Fritillariae Cirrhosae, Rhizoma Pinelliae Preparatum
Weight portion is less than the weight portion of other medical material；It is furthermore preferred that the weight portion of Fructus Evodiae is minimum.
7. treating a Chinese medicine composition for gastritis, raw material consists of:
Radix Bupleuri 10 weight portion, Fructus Aurantii 10 weight portion, the Radix Paeoniae Alba 15 weight portion, Rhizoma Cyperi 10 weight portion,
Radix Glycyrrhizae 10 weight portion, Radix Glycyrrhizae Preparata 10 weight portion, Endoconcha Sepiae 10 weight portion, Bulbus Fritillariae Thunbergii 10 weight portion,
Herba Taraxaci 10 weight portion, Radix Scutellariae 10 weight portion, Rhizoma Pinelliae Preparatum 9 weight portion, Rhizoma Coptidis 6 weight portion, Wu Zhu
Cornel 2 weight portion, Poria 15 weight portion, Herba Eupatorii 10 weight portion, Massa Medicata Fermentata (parched to brown) 15 weight portion, Fructus Crataegi (parched to brown)
15 weight portions, Fructus Hordei Germinatus (parched to brown) 15 weight portion, Herba Pogostemonis 10 weight portion, Bulbus Fritillariae Cirrhosae 6 weight portion, Rhizoma Alpiniae Officinarum 6
Weight portion.
8. the preparation method of the Chinese medicine composition according to any one of claim 1 to 7, including walking as follows
Rapid:
By the raw material of described weight portion, directly pulverize or through water or the extraction with aqueous solution of ethanol, add or
It is added without pharmaceutically acceptable adjuvant, according to this area conventional method, makes and can accept clinically
Preparation；
Preferably, the described preparation of acceptable clinically is preferably oral formulations, more preferably water decoction,
Oral liquid, honey pill agent, watered pill, concentrated pill, capsule or tablet.
9. the medicine that the preparation method described in claim 8 prepares.
10. the Chinese medicine composition described in any one in claim 1 to 7, or claim 9 institute
The medicine stated application in the medicine of preparation treatment gastritis；
Preferably, described gastritis includes acute gastritis and chronic gastritis；Wherein, chronic gastritis includes shallow table
Property gastritis, chronic erosive gastritis and atrophic gastritis.
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| CN106563100A (en) * | 2016-09-19 | 2017-04-19 | 陈亚杰 | Stomach invigorating honey and preparation method thereof |
| CN108498747A (en) * | 2017-05-16 | 2018-09-07 | 苏州赵陈生物科技有限公司 | A kind of Chinese medicine composition for treating gastritis |
| CN115487223A (en) * | 2022-07-18 | 2022-12-20 | 四川全泰堂中药饮片有限公司 | Method for processing honey-fried licorice roots |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102205087A (en) * | 2011-05-23 | 2011-10-05 | 刘明述 | Chinese medicinal composition for treating chronic gastritis and preparation method thereof |
| CN102988670A (en) * | 2012-11-20 | 2013-03-27 | 王玮 | Traditional Chinese medicine for treating gastritis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102205087A (en) * | 2011-05-23 | 2011-10-05 | 刘明述 | Chinese medicinal composition for treating chronic gastritis and preparation method thereof |
| CN102988670A (en) * | 2012-11-20 | 2013-03-27 | 王玮 | Traditional Chinese medicine for treating gastritis |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106563100A (en) * | 2016-09-19 | 2017-04-19 | 陈亚杰 | Stomach invigorating honey and preparation method thereof |
| CN108498747A (en) * | 2017-05-16 | 2018-09-07 | 苏州赵陈生物科技有限公司 | A kind of Chinese medicine composition for treating gastritis |
| CN115487223A (en) * | 2022-07-18 | 2022-12-20 | 四川全泰堂中药饮片有限公司 | Method for processing honey-fried licorice roots |
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