CN104398643A - Traditional Chinese medicine composition treating dermatitis and eczema - Google Patents

Traditional Chinese medicine composition treating dermatitis and eczema Download PDF

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CN104398643A
CN104398643A CN201410643136.4A CN201410643136A CN104398643A CN 104398643 A CN104398643 A CN 104398643A CN 201410643136 A CN201410643136 A CN 201410643136A CN 104398643 A CN104398643 A CN 104398643A
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晏子辉
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    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/04Sulfur, selenium or tellurium; Compounds thereof
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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Abstract

The invention discloses a traditional Chinese medicine composition treating dermatitis and eczema, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises, in parts by weight, 25-36 parts of pericarpium zanthoxyli, 24-32 parts of blumea riparia, 27-34 parts of fructus xanthii, 25-35 parts of radix angelicae dahuricae, 22-36 parts of flos chrysanthemi indici, 24-32 parts of glauber's salt, 22-32 parts of sulfur, 26-37 parts of radix sophorae flavescentis, and 25-35 parts of fructus liquidambaris. The traditional Chinese medicine composition is simple in composition, has special delicate fragrance and has substantial treatment effect on dermatitis and eczema.

Description

A kind of Chinese medicine composition being used for the treatment of dermatitis and eczema
Technical field
The present invention relates to technical field of traditional Chinese medicine, be specifically related to a kind of Chinese medicine composition (skin disease spirit lotion) being used for the treatment of dermatitis and eczema, particularly relate to a kind of lotion being used for the treatment of dermatitis and eczema.
Background technology
Eczema and dermatitis are clinical common, multiple dermatosiss, account for the 15%-30% of dermatological department Number of Outpatients, wherein especially common with acute eczema, dermatitis, are one of emphasis problems of the clinical and basic research of domestic and international Dermatology.Because primary disease often has strong pruritus, exudate is many, easily recurs, especially prolonged and repeated outbreak and general of skin lesion more painful, be one of emphasis problem of the clinical and basic research of domestic and international dermatosis.Modern medicine proves, the pathological change of eczema is all occur intercellular edema (sponge formation) and intracellular edema at epidermis, and high dermis has telangiectasis, edema and monocyte infiltration.From clinically, eczema often not easily finds clear and definite reason.In recent years think, eczema is Tardive allergy disease, is caused by multiple internal and external factor, relevant with inherited genetic factors.A lot of so-called universal eczema, disseminated neurodermatitis etc., in fact all belong to atopic dermatitis (or eczema).
At present, the medicines such as clinical treatment these disease many employings antiallergic, calmness, hormones, as antibiotic, gamma hch frost, econazole, Miconazole etc.They are mostly Western medicine preparation, and the patient that, symptom shorter for sick time is lighter, these medicines still have certain effect.But the patient that, the state of an illness longer for the course of disease is heavier, only there is temporary transient itching-relieving action in these medicines, the basic possibility without curing.Also some patient can produce certain drug resistance after long-time medication repeatedly, at this moment even itching-relieving action also can be without.
Summary of the invention
The invention provides a kind of Chinese medicine composition being used for the treatment of dermatitis and eczema, there is the advantages such as proportioning is simple, cheaper starting materials, and preparation is simple and easy to use.Described technical scheme is as follows: its composition with parts by weight is: Pericarpium Zanthoxyli 25-36 part, Herba Hieracii Umbellati 24-32 part, Fructus Xanthii 27-34 part, Radix Angelicae Dahuricae 25-35 part, Flos Chrysanthemi Indici 22-36 part, Mirabilitum 24-32 part, sulfur 22-32 part, Radix Sophorae Flavescentis 26-37 part, Fructus Liquidambaris 25-35 part.
Preferably, its composition with parts by weight is: 30 parts, Pericarpium Zanthoxyli, Herba Hieracii Umbellati 30 parts, Fructus Xanthii 30 parts, the Radix Angelicae Dahuricae 30 parts, Flos Chrysanthemi Indici 30 parts, Mirabilitum 30 parts, 30 parts, sulfur, Radix Sophorae Flavescentis 30 parts, Fructus Liquidambaris 30 parts.
Wherein, the Chinese medicine composition that the embodiment of the present invention provides is lotion, and fresh processing, cleans while hot, is " crude drug in whole ", Be very effective; Certainly it can be also other medicine for external use, and as emulsifiable paste, liniment or ointment etc., but effect is slightly not so good as.
 
Wherein, the preparation method of aforementioned lotion is:
(1) parch: get Pericarpium Zanthoxyli 25-36 weight portion by proportioning, Herba Hieracii Umbellati 24-32 weight portion, Fructus Xanthii 27-34 weight portion, Radix Angelicae Dahuricae 25-35 weight portion, Flos Chrysanthemi Indici 22-36 weight portion, Radix Sophorae Flavescentis 26-37 weight portion, Fructus Liquidambaris 25-35 weight portion fry into sallow dry shape, pulverize; By getting Mirabilitum 24-32 weight portion by proportioning and sulfur 22-32 weight portion is pulverized.Wherein, Pericarpium Zanthoxyli, Herba Hieracii Umbellati, Fructus Xanthii, the Radix Angelicae Dahuricae, Flos Chrysanthemi Indici, Radix Sophorae Flavescentis and Fructus Liquidambaris, can use fresh medical material, and section or arrangement, carry out parch after air-dry.Wherein, Pericarpium Zanthoxyli preferably adopts pericarpium Zanthoxyli.
(2) decoct: by proportioning, each raw material mixing is loaded gauze bag (200-300g every bag), after 70-80 DEG C, stop heating with the decocting of 5-7 times of weight, cooling (50-55 DEG C) namely can clean affected part afterwards.
Wherein the using method of this lotion is: aforementioned lotion is cooled to 50-55 DEG C, cleans affected part while hot, and sooner or later respectively once, during follow-up use, be heated to 50-55 DEG C of use, within five days, be a course for the treatment of, 1-2 cures the course for the treatment of.
In the lotion provided of the present invention key agents introduction and drug action mechanism as follows:
Pericarpium Zanthoxyli, latin name Zanthoxylum bungeanum Maxim., the traditional Chinese medical science is thought, Pericarpium Zanthoxyli is warm in nature, acrid in the mouth, has warming spleen and stomach for dispelling cold, stomach invigorating dehumidifying, pain relieving parasite killing, removing toxic substances are regulated the flow of vital energy, effect of antipruritic raw meat of dispelling.Analgesic activity: pepper water extract 5-10g/kg and ether extract 3.0-6.0ml/kg has obvious inhibitory action to the mouse writhing reaction that acetic acid causes, the equal <0.05 of water extract P, ether extract 3.0ml/kg(P<0.05), ether extract 6.0ml/kg(P<0.01), wherein comparatively water extract is strong in the effect of ether extract, and in dose dependent.Bacteriostasis: this product volatile oil 11 kinds of dermatophytosises and 4 kinds of deep fungals all have certain suppression and killing action, wherein Pilus Caprae seu Ovis sample sporidiole bacteria and trichophyton the most responsive, MIC is 0.1HL/ml lower than 0.1HL/ml, MFC.Experiment confirms that laurocapram and dimethyl sulfoxide can promote that volatile oil enters in fungal cell and accelerate cell death.
Herba Hieracii Umbellati, latin name: Senecio scandens Buch.-Ham. ex D. Don, has heat-clearing and toxic substances removing; Improving acuity of vision and removing nebula; The effect of killing parasites for relieving itching.50% decoct, stronger antibacterial action is had to will Hayes dysentery bar mattress and staphylococcus aureus, valid density is respectively 1:1024 and 1:512, to bacillus such as typhoid fever, paratyphoid fever, paratyphoid fever, dysentery (Fu Shi, Boydii, Song Nei Shi), large intestine, distortion, cured sample anthraxs, and sarcina all has inhibitory action (in vitro doubling dilution).Oral absorption good (rat), the urine of discharge also has certain antibacterial action.
Fructus Xanthii, latin name anthium sibiricum, the fruit of dicotyledon Compositae Herba Xanthii and Herba Xanthii mongolici maturation zone involucre.There is loose wind dehumidifying effect such as sensible.Antiinflammatory action: the diterpene hydroxy acid potassium atractylate contained by these product shows there is antiinflammatory action through rat carrageenan Edema Test.Lumbar injection, subcutaneous injection and oral LD50 are respectively 2.9, and 5.3 and 350mg/kg.Fructus Xanthii decoct has bacteriostasis to staphylococcus aureus in vitro, and acetone or alcohol extract has bacteriostasis to trichophyton in vitro.
The Radix Angelicae Dahuricae, effect: induce sweat cold expelling, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis, dispelling wind for relieving itching.
Flos Chrysanthemi Indici, latin name: Dendranthema indicum, is Compositae herbaceos perennial, cures mainly: furuncle; Carbuncle; Erysipelas; Eczema; Dermatitis; Laryngopharynx swelling and pain.To staphylococcus aureus, diphtheria corynebacterium, streptococcus, bacillus pyocyaneus, puncture Shigella, influenza virus, all there is inhibitory action.The aeruginous volatile oil of Flos Chrysanthemi Indici water extract and extraction by steam distillation is killed or inhibit activities various pathogens, virus, and the inhibit activities of water extract to staphylococcus aureus, dysentery bacterium, escherichia coli, Bacillus typhi etc. is better than volatile oil; And have antiinflammatory, antioxidation, analgesic activities.
Sulfur, main containing elemental sulfur S8, sulfur and Sublimed Sulfur are when suitable dosage and the course for the treatment of, obvious therapeutic effect is presented to rat formaldehyde " arthritis ". once oral 900mg/kg, every day 2 times, with sodium salicylate 600mg/kg(every day 1 time) action effect close. Sublimed Sulfur can also reduce the permeability that rat capillary produces because of albumen injection and increase.Sulfur and contact skin, can generate hydrogen sulfide under body temperature, has the effect killing sarcoptic mite; And by certain microorganism or epithelial effect, and pentathionic acid may be oxidized to, and there is sterilization and fungicidal effect. in addition, sulfide still has dissolving cutin and depilation, can be used for treating for skin disease.
Radix Sophorae Flavescentis, latin name Sophora flavescens is the plant that pulse family Radix Sophorae Flavescentis belongs to.Radix Sophorae Flavescentis has the effect of anti-inflammation, all has inhibitory action to Propiobacterium, staphylococcus aureus, escherichia coli, can diuresis, antiallergic, ease pain, relieving asthma, eliminate the phlegm.Intramuscular injection oxymatrine obviously can resist the exudative inflammation that Oleum Tiglii, carrageenin (rat) and glacial acetic acid (mice) bring out.
Fructus Liquidambaris, latin name Fructus Lipuidambaris Liquidambar taiwaniana Hance, expelling wind and removing dampness, promoting flow of QI and blood.Treating rheumatic lumbago, heart peratodynia, hypogalactia, eczema, dermatitis.
In formula, sulfur has defat, sterilization, conversion epidermis, separates cutin effect; Pericarpium Zanthoxyli, Fructus Xanthii, the Radix Angelicae Dahuricae, there is bacterio static itching-relieving effect; Flos Chrysanthemi Indici, Radix Sophorae Flavescentis, Herba Hieracii Umbellati, Mirabilitum etc. have antipyretic and antidote functions; Fructus Liquidambaris, Pericarpium Zanthoxyli antipruritic effect highly significant.All medicines share the concrete inhibitory action such as golden staphylococcus, pus bacillus, Bacillus typhi, trichophyton, Candida albicans, Sabouraudites lanosus, can be antipruritic and can kill worm and worm's ovum.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is:
1, the composition of Chinese medicine composition that provides of the embodiment of the present invention is very simple and cheap, and is also very easy to preparation, is applicable to average family and uses.
2, the Chinese medicine composition that the embodiment of the present invention provides has special delicate fragrance, free from extraneous odour, is convenient to external and uses, can not cause embarrassment.
3, the Chinese medicine composition that provides of the embodiment of the present invention is remarkable to the therapeutic effect of dermatitis and eczema, not easily recurs, can reach at all double and control.
 
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearly, below embodiment of the present invention is described further in detail.
Embodiment 1-6 provides the concrete formula of the lotion being used for the treatment of dermatitis and eczema, specifically as shown in table 1:
Table 1
Weight (g) Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4 Embodiment 5 Embodiment 6
Pericarpium Zanthoxyli 25 36 30 27 32 27
Herba Hieracii Umbellati 24 32 30 25 28 31
Fructus Xanthii 27 34 30 31 29 28
The Radix Angelicae Dahuricae 25 35 30 27 30 32
Flos Chrysanthemi Indici 22 36 30 32 25 28
Mirabilitum 24 32 30 28 25 27
Sulfur 22 32 30 25 28 30
Radix Sophorae Flavescentis 26 37 30 32 28 35
Fructus Liquidambaris 25 35 30 31 28 27
Its preparation method is:
(1) parch: get Pericarpium Zanthoxyli, Herba Hieracii Umbellati, Fructus Xanthii, the Radix Angelicae Dahuricae, Flos Chrysanthemi Indici, Radix Sophorae Flavescentis and Fructus Liquidambaris by proportioning and fry into sallow dry shape, pulverizes; By getting Mirabilitum by proportioning and sulfur is pulverized.
(2) decoct: each raw material mixing is loaded gauze bag, after 70-80 DEG C, stop heating with the decocting of 5-7 times of weight, after being cooled to 50-55 DEG C, can affected part be cleaned.
Clinical example
Test example 1 medicine effect test of the present invention (medicine xylol causes mice ear experiment, the experiment of formaldehyde rat paw edema and the experiment of rat granuloma induced by implantation of cotton pellets)
1.1, animal cleaning grade ICR system mice 120, male female half and half, weight 18-22g, be purchased from Central China University of Science and Technology's Experimental Animal Center; Holland germline pure white Cavia porcellus 24, male female half and half, weight 210-260g, purchased from Central China University of Science and Technology's Experimental Animal Center.
1.2, reagent dimethylbenzene: the Chinese People's Liberation Army the 9066th plant produced.4-aminopyridine (4-AP): FLUKA company produces.Dinitrochlorobenzene (DNCB): Military Medical Science Institute's medical supply station produces.
1.3, medicine: the embodiment of the present invention is made obtains lotion.Mainly to use Pericarpium Zanthoxyli 30g, Herba Hieracii Umbellati 30g, Fructus Xanthii 30g, Radix Angelicae Dahuricae 30g, Flos Chrysanthemi Indici 30g, Mirabilitum 30g, sulfur 30g, Radix Sophorae Flavescentis 30g, Fructus Liquidambaris 30g, after 70-80 DEG C, stop heating with the decocting of 6 times of weight. cooling uses.The present invention is made into the lotion of low concentration (diluting a times), middle concentration (stock solution), high concentration (concentrated a times) respectively with substrate, another distilled water diluting is the medicinal liquid of 30%, for subsequent use.PIYANPING: contrast medicine, commercially available.
1.4 instrument micrometer calipers, 6mm card punch, 12mm card punch.
2.1, invention xylol causes the impact of mice auricle swelling.ICR system mice 60, is divided into 6 groups at random, often organizes 10, male and female half and half.Medication group is applied in mice two auricular concha two sides with basic, normal, high concentration 0.5g of the present invention respectively, and model group external-use substrate 0.5g positive drug control group is coated with Piyanping ointment 0.2g outward, every day coating 3 times, for three days on end.1h after last coating, drips dimethylbenzene 0.03ml and causes inflammation in mouse right ear shell two sides, after 3h, mice dislocation is put to death, and take off circular auricle at the symmetrical place of left and right ear respectively with diameter 6mm card punch, analytical balance is weighed.The of poor quality of ears is swelling, and its data are as shown in table 2.
Table 2
Group Model group Low concentration Middle concentration High concentration PIYANPING matched group
Two ears are of poor quality 9.42±3.21 7.81±3.23 5.64±3.39 5.97±3.41 3.25±2.95
In table 2, tested by medicine of the present invention, 3 concentration group mice auricular concha swellings are all remarkable in model control group, show that medicine xylol of the present invention causes chmice acute ear swelling and has inhibitory action, in addition, the inhibitory action of low concentration is general, and the inhibition of middle and high concentration is remarkable.Its effect is worse than PIYANPING.
Meanwhile, the experiment of formaldehyde rat paw edema and the experiment of rat granuloma induced by implantation of cotton pellets have also been done in this experiment simultaneously, and its experimentation, known by those skilled in the art, specifically causes the impact of mice ear see aforesaid medicine xylol.In the experiment of formaldehyde rat paw edema, when carrageenin local injection brings out rat 1-7 hour sufficient pawl swelling peak, medicine of the present invention 3 concentration group rat foot claw swellings are starkly lower than matched group, show that medicine on Carrageenan local injection of the present invention brings out rat foot claw swelling and has inhibitory action.In the experiment of rat granuloma induced by implantation of cotton pellets, tested by medicine of the present invention, three dosage group granuloma induced by implantation of cotton pellets weigh less than and matched group granuloma weight, significant difference highly significant, can think that this medicine can suppress the formation of cotton balls granulation tissue, have antiinflammatory action to this inflammatory model.Meanwhile, data show, and the effect of low concentration is a little less than middle and high concentration.
Test example 2 medicine of the present invention is to the bacteriostasis of common bacterial strain
Solid process antibacterial action: line on blood ware or common plate so that various test organisms is intensive, with the punching of 8mm card punch, every hole adds aseptic reagent medicine and is about 0.2mL, 18-24 hour is cultivated at 37 DEG C, observe the size of inhibition zone, for lotion of the present invention, judge that its responsive result is as shown in table 2.
Table 3
Strain Bacterial strain Low concentration Middle concentration High concentration PIYANPING matched group
Gold staphylococcus ATCC 29213 - ++ ++ +++
Pus bacillus ATCC 9027 - ++ +++ -
Salmonella typhi ATCC 14028 ++ ++ +++ ++
Trichophyton ATCC 28188 + ++ ++ +++
Candida albicans ATCC 90029 ++ +++ +++ ++
Sabouraudites lanosus ATCC 11621 + ++ ++++ +++
In table: antibacterial circle diameter < 9mm, drug resistance-; Antibacterial circle diameter 9-14mm(does not comprise 14mm), slight sensitive+; Antibacterial circle diameter 14-19mm(does not comprise 19mm), medium sensitivity ++; Antibacterial circle diameter 20-29mm(does not comprise 29mm), extremely sensitive +++; Antibacterial circle diameter >=29, special extremely sensitive ++++.Wherein, the concrete source of three concentration groups, causes mice ear experiment see medicine xylol.This Chinese medicine composition has the effect of certain suppression to common bacterial strain as can be seen from Table 3.
Test example 3 clinical drug trial of the present invention
1, case statistics: case is selected from Luotian County and periphery, acquisition time 2 years, and number is 182; Wherein, man 113 example, female 69 example, age 15-65 year, 43 years old mean age.Be divided into matched group 90 people, experimental group 92 people, the statistical distribution of matched group and experimental group is similar; Wherein, experimental group adopts lotion of the present invention, and every day, sooner or later respectively once life cycle 10 days, observed 1 year cycle; Experimental group adopts Piyanping ointment, every day three times, each 0.2g, and life cycle one week observes 1 year cycle.Wherein, experimental group man 57 example, female 35 example, age 16-63 year, 41 years old mean age, wherein, eczema 53 example, allergic dermatitis 18 example, neurodermatitis 11 example, tinea 7 example, other 3 example.
2, medicine preparation: get Pericarpium Zanthoxyli 25-36g, Herba Hieracii Umbellati 24-32g, Fructus Xanthii 27-34g, Radix Angelicae Dahuricae 25-35g, Flos Chrysanthemi Indici 22-36g, Radix Sophorae Flavescentis 26-37g and Fructus Liquidambaris 25-35g by proportioning and fry into sallow dry shape, pulverizes; By getting Mirabilitum 24-32g by proportioning and sulfur 22-32g pulverizes: by proportioning, each raw material mixing is loaded gauze bag (200-300g every bag), after 70-80 DEG C, stop heating with the decocting of raw material 5-7 times weight, it is for subsequent use that lotion is made in cooling.
3, drug use method: according to the state of an illness, selects suitable formula proportion, aforementioned lotion is cooled to 50-55 DEG C, cleans affected part while hot, and sooner or later respectively once, during follow-up use, be heated to 50-55 DEG C of use, within five days, be a course for the treatment of, 1-2 cures the course for the treatment of.
4, diagnostic criteria: dermatitis, eczema show as skin rubefaction, occur pimple, or the granular erythema of Semen setariae, getting blister in top, itches, and scratches rear flowing water, and contamination in flakes, can be formed a scab.
5, criterion of cure: recovery from illness: erythra disappears completely, gargalesthesia disappears; Effective: deflorescence more than 60%, gargalesthesia obviously alleviates; Effective: deflorescence 20-60%, gargalesthesia alleviates; Invalid: symptom and sign are without change, and deflorescence less than 20%, or continues to increase the weight of.
6, therapeutic outcome: according to clinical symptoms, uses this washing liquid of various dose after 5 to 10 days, cures 41 examples, accounts for 44.6%; Effective 27 examples, account for 29.3%; Effective 16 examples, account for 20.7%; Invalid 8 examples, account for 8.7%; Total effective rate 91.3%, wherein, during this lotion 5 days, total effective rate reaches 65.3%, reach 91.3%, but the therapeutic effect of this lotion to neurodermatitis is poor when 10 days.In addition, matched group, total effective rate is 84.3%, uses and namely has positive effect in 2-3 days; But according to return visit (in a year), the relapse rate of experimental group is 22.7%, the relapse rate of matched group up to 49.3%, i.e. effective compared with PIYANPING of the radical cure effect of this lotion.Therapeutic outcome is as shown in table 4.
Table 4
Sick kind Number of cases Cure Cure rate Effective Obvious effective rate Effectively Effective percentage Invalid Inefficiency
Eczema 53 27 50.9% 18 34.0% 5 9.4% 3 5.7%
Allergic dermatitis 18 10 55.5% 3 16.7% 4 22.2% 1 5.6%
Neurodermatitis 11 3 27.3% 5 45.5% 3 27.3%
Tinea 7 3 42.8% 2 28.6% 2 28.6%
Other 3 1 33.3% 1 33.3% 1 33.3%
Add up to 92 41 44.6% 27 29.3% 16 20.7% 8 8.7%
Concrete clinical case:
Clinical data:
Implement 1: Zhang, man, 23 years old, people from Huang gang.Medical history: patient plays rash over 3 years repeatedly, conscious pruritus, was once diagnosed as " eczema " in Duo Jia hospital, external PIYANPING and fluocinonide treatment, and skin lesion is not healed, time light time heavy, often repeatedly.Indagation: the plump coarse patch of both hands back crineous, the both hands palm keratinization, fissum speckle, pale tongue tongue is white, deep-slow pulse.Western medicine diagnose: eczema rhagadiforme.Use this lotion 10 days, wash 2 day, pruritus stops, and the fissum speckle of both hands keratinization disappears, and hand skin is smooth.Follow up a case by regular visits to 1 year without recurrence.
Implement 2: Song, female, 43 years old, people from Wuhan, came because of respect for the fame.Medical history: play erythra without obvious inducement body before patient's first quarter moon, the Drug therapys such as pruritus is serious, flowing water after scratching, and oral ketoboidies is fragrant, have no obvious curative effects.Existing patient skin pruritus, vexed insomnia, yellow urine.Indagation: trunk, extremity are dispersed in erythema, vesicle, symmetrical, indefinite border.Skin lesions circumferece is dispersed in scratch incrustation, red tongue, yellow and greasy fur, wiry and frequent pulse.Western medicine diagnose: acute eczema.Use this lotion 5 days, wash 2 day, pruritus obviously alleviates, and oozes out minimizing; Use this lotion 10 days, the dry desquamation of skin lesion, basic recovery is normal.Continue use recovery from illness in 3 days.Follow up a case by regular visits to 1 year without recurrence.
 
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (4)

1. one kind is used for the treatment of the Chinese medicine composition of dermatitis and eczema, it is characterized in that, its composition with parts by weight is: Pericarpium Zanthoxyli 25-36 part, Herba Hieracii Umbellati 24-32 part, Fructus Xanthii 27-34 part, Radix Angelicae Dahuricae 25-35 part, Flos Chrysanthemi Indici 22-36 part, Mirabilitum 24-32 part, sulfur 22-32 part, Radix Sophorae Flavescentis 26-37 part, Fructus Liquidambaris 25-35 part.
2. the Chinese medicine composition being used for the treatment of dermatitis and eczema according to claim 1, it is characterized in that, its composition with parts by weight is: 30 parts, Pericarpium Zanthoxyli, Herba Hieracii Umbellati 30 parts, Fructus Xanthii 30 parts, the Radix Angelicae Dahuricae 30 parts, Flos Chrysanthemi Indici 30 parts, Mirabilitum 30 parts, 30 parts, sulfur, Radix Sophorae Flavescentis 30 parts, Fructus Liquidambaris 30 parts.
3. the Chinese medicine composition being used for the treatment of dermatitis and eczema according to claim 1 and 2, is characterized in that, described Chinese medicine composition is lotion.
4. the Chinese medicine composition being used for the treatment of dermatitis and eczema according to claim 3, is characterized in that, its preparation method is:
(1) parch: get Pericarpium Zanthoxyli, Herba Hieracii Umbellati, Fructus Xanthii, the Radix Angelicae Dahuricae, Flos Chrysanthemi Indici, Radix Sophorae Flavescentis and Fructus Liquidambaris by proportioning and fry into sallow dry shape, pulverizes; By getting Mirabilitum by proportioning and sulfur is pulverized;
(2) decoct: each raw material mixing is loaded gauze bag, after 70-80 DEG C, stop heating with the decocting of 5-7 times of weight, after cooling, can affected part be cleaned.
CN201410643136.4A 2014-11-14 2014-11-14 A kind of Chinese medicine composition for treating dermatitis and eczema Active CN104398643B (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105796844A (en) * 2016-03-16 2016-07-27 高保成 Traditional Chinese medicine composition for treating dermatitis
CN106177693A (en) * 2016-09-27 2016-12-07 泰山医学院 A kind of Chinese medicine for treating eczema and compound recipe solution thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
中国药材公司: "《中国民间单验方》", 31 October 1994 *
王广津等,: "《疮疡外用本草》", 31 January 1982 *
罗和古等,: "《经方验方巧治皮肤病(上册)》", 31 August 2007 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105796844A (en) * 2016-03-16 2016-07-27 高保成 Traditional Chinese medicine composition for treating dermatitis
CN106177693A (en) * 2016-09-27 2016-12-07 泰山医学院 A kind of Chinese medicine for treating eczema and compound recipe solution thereof

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