CN104324251A - Intelligence-reinforcing and nerve-calming medicine for treating congenital atelencephalia and preparation method - Google Patents
Intelligence-reinforcing and nerve-calming medicine for treating congenital atelencephalia and preparation method Download PDFInfo
- Publication number
- CN104324251A CN104324251A CN201410673322.2A CN201410673322A CN104324251A CN 104324251 A CN104324251 A CN 104324251A CN 201410673322 A CN201410673322 A CN 201410673322A CN 104324251 A CN104324251 A CN 104324251A
- Authority
- CN
- China
- Prior art keywords
- parts
- herba
- poria
- decoct
- congenital
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/64—Orobanchaceae (Broom-rape family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8884—Arisaema, e.g. Jack in the pulpit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses an intelligence-reinforcing and nerve-calming medicine for treating congenital atelencephalia. The medicine is prepared from the following raw materials in parts by weight: 9-16 parts of cistanche, 3-9 parts of glossy privet fruit, 5-8 parts of radix stephaniae tetrandrae, 5-10 parts of typhonium giganteum, 6-12 parts of garden balsam stem, 3-5 parts of calamus, 6-9 parts of poria with hostwood, 7-15 parts of poria cocos, 4-8 parts of gastrodia elata, 3-6 parts of stauntonia elliptica, 9-15 parts of angelica sinensis, 4-9 parts of semen litchi, 6-12 parts of rhizoma alismatis, 3-6 parts of securinega suffruticosa and 4-6 parts of immature bitter orange. The intelligence-reinforcing and nerve-calming medicine for treating the congenital atelencephalia is developed according to the traditional Chinese medicine principle in combination with the physical and mental characteristics of the child patients of the congenital atelencephalia, and is capable of promoting the development of the brain, tonifying the brain and reinforcing intelligence; the obtained product is good in curative effect, safe and reliable without any adverse effect.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to one and treat Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament and preparation method thereof.
Background technology
Cerebral dysgenesis refers to and causes by low certain reason heavy, birth defect, neonatal hypoxia ischemia etc. of premature labor a kind of disease that cerebral tissue reduces, cranial nerve cell growth is unsound or impaired and appearance is feature with mental retardation and growth retardation.Main clinical manifestation has intelligent development obstacle, dysaudia, hypoevolutism, the lighter's intelligence is close to normal or low, and the multi-lingual or being reticent of polylogia, many dynamic or dull, actions do not keep away that close and distant, attention is difficult to concentrate, emotional lability, inflammable, dream is many, the enuresis etc.; Severe one dementia, sialorrhea, aphasia, apraxia, hemiplegia, panplegia, cry by force, gatism etc. of putting on an air of cheerfulness.Cerebral dysgenesis belongs to traditional Chinese medical science five kinds of growth retardation category, and five kinds of growth retardation is the class encephalopathy that brain development is slow, general reference retardation of standing, the walking retardation in children, retardation in tooth eruption, tardiness of speaking in infant, retardation of hair-growing etc.Five kinds of growth retardation is the disease of its pathological characters with positive QI-insufficiency, its cause of disease nothing more than congenital factors and the day after tomorrow less than two aspects, summary ancient Chinese medicine doctor probing into its etiology and pathogenesis, what have sets forth one's views from heart caused by liver and kidney deficiency, have from deficiency of both the heart and spleen division, what have thinks congenital deficiency, and thinking of also having is taken good care of inappropriate, but total nothing more than congenital factors and acquired disposition two aspects.Congenital factors refers to fetus innate deficiency or is subject to pessimal stimulation.If father and mother's body constitution element is empty, vital essence is feeble and exhausted.Or prolonged illness just Liao, or poison of drug infringement, or addiction number partially, cause tire and report bad; Or pregnant phase indulge in sensual pleasures, injure the form of the foetus or pregnant mother is frightened, pathogen takes advantage of the heart, or tumbling down internal injury, causes born of the same parents to damage, and all can make infant congenital deficiency, and Liver and kidney is by fingerprint, and essence and blood can not flourish note muscles and bones and falling ill.Because rear native endowments are born in congenital, and congenitally depend on posteriori supporting, congenital defect, then after, native endowments are weak, and do not fill the day after tomorrow, then congenital drying up exhausts.To interact both deficiency congenital factors and the day after tomorrow.Disease relates to the five internal organs ownership to be had different, and the pathogenic characteristic of various slow card is also different.
Publication number CN 104042906 A(application number 201410278322.2) Chinese patent literature disclose one and to calm the nerves Fructus Alpiniae Oxyphyllae Chinese medicine oral liquid and preparation method thereof, formulated in right amount primarily of Rhizoma Polygonati 15-25, Fructus Jujubae 22-28, Poria cum Radix Pini 20-30, Radix Codonopsis 16-24, Rhizoma Acori Graminei 10-15, Tilia europaea 17-26, Semen Juglandis 14-22, Rhizoma Polygonati Odorati 10-15, Folium Ziziphi Spinosae 8-14, Radix Polygalae 5-10, Semen Platycladi 11-19, Herba Angelicae Keiskei 13-21, Rhizoma Dioscoreae 26-32, Fructus Schisandrae Chinensis 7-13, Radix Ophiopogonis 24-32, Radix hemerocalis plicatae 16-22, sucrose 30-40, water.Publication number CN 101804133 A(application number 201010140515.3) Chinese patent literature disclose a kind ofly be used for the treatment of that development in children is slow, the Chinese medicine composition of mental retardation and preparation method thereof, said composition consists of the raw materials such as Radix Rehmanniae Preparata, Caulis Polygoni Multiflori, Rhizoma Acori Graminei, the Cortex Eucommiae, Radix Notoginseng, Fructus Schisandrae Chinensis.Publication number CN 103041157 A(application number 201310022390.8) Chinese patent literature disclose a kind of nourishing the brain and improving intelligence ball and preparation method thereof, raw material consists of: vinegar Carapax et Plastrum Testudinis 20-30g, Os Draconis 20-30g, Plumula Nelumbinis 15-20g, Poria cum Radix Pini 3-5g, Radix Ophiopogonis 12-18g, Radix Polygalae 20-30g, Semen Ziziphi Spinosae (parched) 12-18g Chuan Kong 15-20g, Radix Rehmanniae Preparata 20-30g, Radix Glycyrrhizae Preparata 15-25g, Mel is appropriate.
At present, the treatment for this disease uses Medical Instruments to add the method for Drug therapy combined function training more more, uses more medicine to be the medicine of some nutrition cranial nerve cell classes.About the traditional Chinese medical science formula of this disease is few, therefore, also make great efforts to develop and excavate out more formula about the treatment of this disease.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare medicament of the treatment Congenital maldevelopment of brain of simple and suitable long-term taking and preparation method thereof.
Technical scheme of the present invention is:
Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament, is prepared from primarily of following bulk drugs, is weight portion: Herba Cistanches 9-16, Fructus Ligustri Lucidi 3-9, Radix Stephaniae Tetrandrae 5-8, Herba Typhonii gigantei 5-10, Herba speranskiae tuberculatae 6-12, Rhizoma Acori Graminei 3-5, Poria cum Radix Pini 6-9, Poria 7-15, Rhizoma Gastrodiae 4-8, cattle rattan 3-6, Radix Angelicae Sinensis 9-15, Semen Litchi 4-9, Rhizoma Alismatis 6-12 Cacumen Securinegae Suffruticosae 3-6, Fructus Aurantii Immaturus 4-6.
In preferred scheme, Herba Cistanches 11-14, Fructus Ligustri Lucidi 5-7, Radix Stephaniae Tetrandrae 6-7, Herba Typhonii gigantei 6-9, Herba speranskiae tuberculatae 8-10, Rhizoma Acori Graminei 3.5-4.5, Poria cum Radix Pini 7-8, Poria 9-13, Rhizoma Gastrodiae 5-7, cattle rattan 4-5, Radix Angelicae Sinensis 11-13, Semen Litchi 5-8, Rhizoma Alismatis 8-10, Cacumen Securinegae Suffruticosae 4-5, Fructus Aurantii Immaturus 4.5-5.5.
Be more preferably, Herba Cistanches 12.5, Fructus Ligustri Lucidi 6, Radix Stephaniae Tetrandrae 6.5, Herba Typhonii gigantei 7.5, Herba speranskiae tuberculatae 9, Rhizoma Acori Graminei 4, Poria cum Radix Pini 7.5, Poria 11, Rhizoma Gastrodiae 6, cattle rattan 4.5, Radix Angelicae Sinensis 12, Semen Litchi 6.5, Rhizoma Alismatis 9, Cacumen Securinegae Suffruticosae 4.5, Fructus Aurantii Immaturus 5.
The preparation method of described Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament powder is:
(1) by Herba Cistanches, Fructus Ligustri Lucidi, Herba speranskiae tuberculatae, Poria cum Radix Pini, Rhizoma Gastrodiae, Niu Teng, Semen Litchi and Fructus Aurantii Immaturus decontamination, clean, 40 DEG C of freeze-day with constant temperature, then 120-180 mesh sieve was pulverized (preferred, pulverized 140-160 mesh sieve, be more preferably, pulverized 150 mesh sieves);
(2) by Radix Stephaniae Tetrandrae, Radix Angelicae Sinensis and Rhizoma Alismatis decontamination, clean, section, is placed in pot and makes popular, sprays the saline of medical material weight 0.4 times, slow fire fried dry, and taking-up is dried in the air cool, pulverizes 180 mesh sieves, for subsequent use;
(3) getting other residue medical material Herba Typhonii gigantei, Rhizoma Acori Graminei, Poria and Cacumen Securinegae Suffruticosae is placed in non iron container, add the warm water soaking 1-2 hour of medical material weight 5 times, then big fire is boiled, turn little fire and decoct 30-80 minute (preferably, turn little fire and decoct 40-70 minute, be more preferably, turn little fire and decoct 55 minutes), filter, collect filtrate;
(4) by the heating of step (3) filtrate, to be condensed into relative density be 1.33(60 DEG C) thick paste, then vacuum drying, pulverizes, and cross 200 mesh sieves, and mix with step (1), (2) made powder, sterilizing, is distributed into bag, obtains powder.
Described Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament powder, step (2) saline Zhong Shui and salt mass ratio are 30:1.
Described Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament powder, in step (3), warm water temperature is 40-65 DEG C (preferred, warm water temperature is 45-60 DEG C, is more preferably, and warm water temperature is 55 DEG C).
The preparation method of described unguentum is:
(1) by Herba Cistanches, Fructus Ligustri Lucidi, Poria cum Radix Pini, Rhizoma Gastrodiae, cattle rattan and Semen Litchi decontamination, cleaning, drying, pulverized 60 mesh sieves;
(2) by Radix Stephaniae Tetrandrae, Radix Angelicae Sinensis and Rhizoma Alismatis decontamination, clean, section, is placed in pot and makes popular, sprays the saline (mass ratio of salt and water is 40:1) of quality of medicinal material 0.5 times, slow fire fried dry, and taking-up is dried in the air cool, for subsequent use;
(3) step (1), (2) made medical material are placed in non iron container with other residue medical material Herba Typhonii gigantei, Herba speranskiae tuberculatae, Rhizoma Acori Graminei, Poria, Cacumen Securinegae Suffruticosae together with Fructus Aurantii Immaturus, add the water soaking 2 hours of medical material weight 8 times, then big fire is boiled, turn little fire and decoct 40-80 minute (preferably, turn little fire and decoct 50-70 minute, be more preferably, turn little fire and decoct 60 minutes), filter, collect filtrate;
(4) be watered by step (3) remaining filtering residue, again decoct, filter, merge twice filtrate, then concentrating under reduced pressure is 1/3rd of original volume, adds ethanol while stirring and makes alcohol content reach 60%, leaves standstill 12h, and filter, concentrating under reduced pressure is clear paste, obtains unguentum.
Described Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament unguentum, step (4) decocts 30-50 minute (preferred, again to decoct 35-45 minute, be more preferably, again decoct 40 minutes) again.
Described Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament unguentum, the relative density of step (4) clear paste is 1.20-1.30(60 DEG C) (preferred, the relative density of clear paste is 1.22-1.28, is more preferably, and the relative density of clear paste is 1.25).
The preparation method of described granule is:
(1) by Herba Cistanches, Fructus Ligustri Lucidi, Poria cum Radix Pini, Rhizoma Gastrodiae, cattle rattan and Semen Litchi decontamination, cleaning, drying, pulverized 60 mesh sieves;
(2) by Radix Stephaniae Tetrandrae, Radix Angelicae Sinensis and Rhizoma Alismatis decontamination, clean, section, is placed in pot and makes popular, sprays the saline (mass ratio of salt and water is 30:1) of medical material weight 0.4 times, slow fire fried dry, and taking-up is dried in the air cool, for subsequent use;
(3) step (1), (2) made medical material are placed in non iron container with other residue medical material Herba Typhonii gigantei, Herba speranskiae tuberculatae, Rhizoma Acori Graminei, Poria, Cacumen Securinegae Suffruticosae together with Fructus Aurantii Immaturus, add the water soaking 2 hours of medical material weight 8 times, then big fire is boiled, turn little fire and decoct 40-80 minute (preferably, turn little fire and decoct 50-70 minute, be more preferably, turn little fire and decoct 60 minutes), filter, collect filtrate;
(4) step (3) remaining filtering residue is watered, again decocts 30 minutes, filter, merge twice filtrate, be evaporated to 100ml, then add ethanol while stirring and make alcohol content reach 60%, leave standstill, filter, being evaporated to relative density is 1.30(60 DEG C) clear paste, add pharmacy auxiliary material, dry, pulverize, make granule according to the preparation for processing of granule.
Described Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing pharmacy particle agent, it is preferred that step (4) leaves standstill 18-24h(, leaves standstill 20-22h, be more preferably, and leaves standstill 21h).
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Herba Cistanches: base is former: be the fleshy stem of orobanchaceae plant cistanche or Herba Cistanches, fan's Herba Cistanches etc.Nature and flavor: sweet in the mouth; Salty; Warm in nature.Gui Jing: return kidney channel; Large intestine channel.Effect: kidney-replenishing; Benefiting essence-blood; Intestine moistening road.Cure mainly: kidney yang deficiency; The sexual impotence of asthenia of essence and blood; Seminal emission; Nebulousurine; The frequent micturition heeltap; Lumbago flaccidity of the lower limbs; Tinnitus order flower; Menstruation is spread out the phase; Infertility; Dryness of the intestine constipation.
Fructus Ligustri Lucidi: base is former: be the fruit of Oleaceae Ligustrum plant Fructus Ligustri Lucidi.Composition: fruit is containing triterpenes: oleanolic acid, acetyloleanolic acid, ursolic acid, acetyl ursolic acid; Phenolic glycoside class: p-hydroxyphenylethanol, Hydroxytyrosol, nuzhenide, oleuropein, Fructus Ligustri Lucidi fruit glycosides, Fructus Ligustri Lucidi acid, Fructus Ligustri Lucidi thuja acid etc.The property of medicine: sweet, bitter, cold.Return liver, kidney channel.Function cures mainly: liver and kidney tonifying, improving eyesight.Cure mainly Light-headedness, soreness of the waist and knees, seminal emission, tinnitus, early whitening of beard and hair, osteopyrexia and fever, poor vision.
Radix Stephaniae Tetrandrae: base is former: be the dry root of menispermaceous plants Radix stephaniae tetrandrae.Nature and flavor: bitter, pungent, cold.Gui Jing: return urinary bladder channel, kidney channel, spleen channel.Effect: wind-damp dispelling, pain relieving, diuretic.Cure mainly: Fengshi Guanjie pain; Damp and hot limbs pain; Edema; Dysuria; Beriberi damp-edema.
Herba Typhonii gigantei: base is former: be the herb of aroid Herba Typhonii gigantei.Nature and flavor: acrid, sweet, warm are poisonous.Gui Jing: return stomach, Liver Channel.Effect: drying dampness to eliminate phlegm, timid wind relieving convulsion, removing toxic substances powder knot.Be applicable to the stagnant network of wind-phlegm, facial hemiparalysis, apoplexy abundant expectoration, aphasia hemiplegia, tetanus and headache due to cold-damp; External is used for sucutaneous nodule scrofula, venom.
Herba speranskiae tuberculatae: base is former: the herb of Euphorbiaceae Speranskia plant speranskia tuberculata.Nature and flavor: sweet, pungent, temperature.Gui Jing: enter lung meridian, Liver Channel.Effect: expelling wind and removing dampness, removing toxic substances pain relieving.Cure mainly: for rheumatic arthritis; Sore swollen toxin is controlled in external.
Rhizoma Acori Graminei: nature and flavor: warm in nature, acrid in the mouth, hardship.Effect: ward off and dirtyly to have one's ideas straightened out, a surname's gas by expectorant, removing toxic substances, parasite killing.Cure mainly: demented, infantile convulsion, coma due to phlegm syncope, anemofrigid-damp arthralgia, a mouthful fulminant dysentery of keeping silent, external application carbuncle scabies.Have one's ideas straightened out, reduce phlegm, stomach invigorating., chronic bronchitis vexed for epilepsy, expectorant febrile convulsion, breast abdominal distention.
Poria cum Radix Pini: base is former: for Polyporaceae hole of crouching belongs to the white portion of fungus Poria.Medicinal effects is dry sclerotia body.Nature and flavor: sweet, light are flat.Gui Jing: enter the heart, spleen channel.Effect: mind tranquilizing and the heart calming, diuretic.Cure mainly: be applicable to the diseases such as dysuria, severe palpitation, insomnia forgetfulness.
Poria: base is former: for Polyporaceae hole of crouching belongs to the sclerotium of fungus Poria.Nature and flavor: sweet, light are flat.Gui Jing: GUIXIN, lung, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Rhizoma Gastrodiae: base is former: be the dry tuber of orchid Rhizoma Gastrodiae.Nature and flavor: sweet; Pungent; Flat; Nontoxic.Gui Jing: Liver Channel; Spleen channel; Kidney channel; Gallbladder meridian; Heart channel; Urinary bladder channel.Effect: endogenous wind stopping relieving convulsion; Suppressing the hyperactive liver sun; Dispelling wind and removing obstruction in the collateral.Cure mainly: anxious chronic infantile convulsion; Tic contracture; Dizzy; Headache; Hemiplegia; Limb fiber crops; Rheumatic arthralgia.
Niu Teng: base is former: be stem and the root of that rattan of plants of Lardizabalaceae or that rattan of caudal lobe.Nature and flavor: bitter; Cool.Gui Jing: liver; Urinary bladder channel.Function cures mainly: dispel the wind dissipating blood stasis; Pain relieving; Inducing diuresis to remove edema.Main air pain of dampness syndrome; Traumatic pain; Various neuropathic pain; Dysuria; Edema.
Radix Angelicae Sinensis: base is former: be the root of umbelliferae angelica.Nature and flavor: sweet in the mouth; Pungent; Bitter; Warm in nature.Gui Jing: return Liver Channel; Heart channel; Spleen channel.Effect: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.Cure mainly: all cards of blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Mass in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.
Semen Litchi: base is former: be the seed of sapindaceous plant Fructus Litchi.Nature and flavor: sweet; Micro-hardship; Warm in nature.Gui Jing: Liver Channel; Kidney channel; Spleen channel.Effect: regulating QI to relieve pain; Cold relieving is fallen apart stagnant.Cure mainly: colicky; Painful and swollen testis; Gastric abscess; Dysmenorrhea and puerperal abdonimal pain.
Rhizoma Alismatis: base is former: be the tuber of Notes On Alism At Aceae Rhizoma Alismatis.Nature and flavor: sweet, light, cold in nature.Gui Jing: return kidney channel, urinary bladder channel.Effect: promoting diuresis to eliminate damp pathogen, expel the heat-evil treating stranguria.Cure mainly: the puckery pain of dysuria, pyretic stranguria, edema distension, have loose bowels, dizziness due to fluid-retention, seminal emission.
Cacumen Securinegae Suffruticosae: base is former: be browse or the root of euphorbia plant Suffrutescent Securinega Twig.Nature and flavor: acrid in the mouth; Bitter; Slightly warm in nature; Mild toxicity.Gui Jing: liver; Kidney; Spleen channel.Function cures mainly: expelling wind and activating blood circulation; The strong muscle of kidney tonifying.Main air damp lumbago; Numb limbs and tense tendons; Sexual impotence; Infantile malnutrition; Facial paralysis; Poliomyelitis sequela.
Fructus Aurantii Immaturus: base is former: be the dry young fruit of rutaceae Citrus aurantium Linn. and variety or Fructus Citri sinensis.Nature and flavor: bitter; Pungent; Cold.Gui Jing: spleen channel; Stomach warp; Liver Channel; Heart channel.Effect: dispelling the stagnated QI removing food stagnancy; Reduce phlegm except painful abdominal mass.Cure mainly: stop in stagnant; Feeling of fullness distending pain; Constipation; Heavy after dysentery; Blocked-up chest; Gastroptosis; Uterine prolapse; Proctoptosis.
Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing drug prescription provided by the invention develops according to Chinese medicine principle of medication, and various dosage form makes simple, product taking convenience.In addition, excellent results of the present invention also shows:
1, this prescription there is intelligent promoting and the mind tranquilizing, expelling wind and relieving convulsion, liver and kidney tonifying effect;
2, the present invention is according to Chinese medicine principle, in conjunction with the body and mind feature of Congenital maldevelopment of brain infant, and the promotion brain development developed, the prescription of nourishing the brain and improving intelligence;
3, products obtained therefrom good effect of the present invention, safe and reliable, without any untoward reaction.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament, is prepared from primarily of following bulk drugs: Herba Cistanches 9g, Fructus Ligustri Lucidi 3g, Radix Stephaniae Tetrandrae 5g, Herba Typhonii gigantei 5g, Herba speranskiae tuberculatae 6g, Rhizoma Acori Graminei 3g, Poria cum Radix Pini 6g, Poria 7g, Rhizoma Gastrodiae 4g, cattle rattan 3g, Radix Angelicae Sinensis 9g, Semen Litchi 4g, Rhizoma Alismatis 6g, Cacumen Securinegae Suffruticosae 3g, Fructus Aurantii Immaturus 4g.
The preparation method of above-mentioned Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament powder is:
(1) by Herba Cistanches, Fructus Ligustri Lucidi, Herba speranskiae tuberculatae, Poria cum Radix Pini, Rhizoma Gastrodiae, Niu Teng, Semen Litchi and Fructus Aurantii Immaturus decontamination, clean, 40 DEG C of freeze-day with constant temperature, then pulverized 120 mesh sieves;
(2) by Radix Stephaniae Tetrandrae, Radix Angelicae Sinensis and Rhizoma Alismatis decontamination, clean, section, is placed in pot and makes popular, sprays the saline (water and salt mass ratio are 30:1) of medical material weight 0.4 times, slow fire fried dry, and taking-up is dried in the air cool, pulverizes 180 mesh sieves, for subsequent use;
(3) get other residue medical material Herba Typhonii gigantei, Rhizoma Acori Graminei, Poria and Cacumen Securinegae Suffruticosae to be placed in non iron container, add the warm water soaking 1-2 hour of 65 DEG C of medical material weight 5 times, then big fire is boiled, and turns little fire and decocts 30 minutes, filter, collect filtrate;
(4) by the heating of step (3) filtrate, to be condensed into relative density be 1.33(60 DEG C) thick paste, then vacuum drying, pulverizes, and cross 200 mesh sieves, and mix with step (1), (2) made powder, sterilizing, is distributed into bag, obtains powder.
embodiment 2congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament, is prepared from primarily of following bulk drugs: Herba Cistanches 16g, Fructus Ligustri Lucidi 9g, Radix Stephaniae Tetrandrae 8g, Herba Typhonii gigantei 10g, Herba speranskiae tuberculatae 12g, Rhizoma Acori Graminei 5g, Poria cum Radix Pini 9g, Poria 15g, Rhizoma Gastrodiae 8g, cattle rattan 6g, Radix Angelicae Sinensis 15g, Semen Litchi 9g, Rhizoma Alismatis 12g, Cacumen Securinegae Suffruticosae 6g, Fructus Aurantii Immaturus 6g.
The preparation method of Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament unguentum is:
(1) by Herba Cistanches, Fructus Ligustri Lucidi, Poria cum Radix Pini, Rhizoma Gastrodiae, cattle rattan and Semen Litchi decontamination, cleaning, drying, pulverized 60 mesh sieves;
(2) by Radix Stephaniae Tetrandrae, Radix Angelicae Sinensis and Rhizoma Alismatis decontamination, clean, section, is placed in pot and makes popular, sprays the saline (mass ratio of salt and water is 40:1) of quality of medicinal material 0.5 times, slow fire fried dry, and taking-up is dried in the air cool, for subsequent use;
(3) step (1), (2) made medical material are placed in non iron container with other residue medical material Herba Typhonii gigantei, Herba speranskiae tuberculatae, Rhizoma Acori Graminei, Poria, Cacumen Securinegae Suffruticosae together with Fructus Aurantii Immaturus, add the water soaking 2 hours of medical material weight 8 times, then big fire is boiled, and turns little fire and decocts 50 minutes, filter, collect filtrate;
(4) step (3) remaining filtering residue is watered, again decoct 35 minutes, filter, merge twice filtrate, then concentrating under reduced pressure is 1/3rd of original volume, adds ethanol while stirring and makes alcohol content reach 60%, leave standstill 12h, filter, concentrating under reduced pressure is clear paste, and relative density is 1.22(60 DEG C) namely obtain unguentum.
Model case: xxx, female, 7 months.Father and mother describe, and child cuts open palace and produces, and birth weight is lighter, heavy 2.8kg, has jaundice, and after two weeks, jaundice disappears, poor sleeping quality, easily wakes up with a start during sleep, uneasiness of easily crying and screaming, for a long time just can stop, can not come back, bradykinesia, soft, forehead is less than normal, and cardiopulmonary trusted subordinate is soft, the head of a family finds child's abnormal development hospital admission then, through audition, cardiac ultrasonic, intelligent test, Motor development inspection, is finally diagnosed as Congenital maldevelopment of brain.
Take the present embodiment gained Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament unguentum, each half spoonful, about 4g, every day 2 times, warm boiled water, 30 days courses for the treatment of.After taking one month, infant sleep quality improves, and number of times of waking up in bed obviously reduces, and crying time also obviously shortens, head can slightly on lift, after continue again to take three months, infant hands becomes strong, can sitting and new line, interested sight can be launched to toy, child is slightly slow for infant body development compared with normal, continues again to have taken three months, and intelligent development, verbal ability and ability to act recover normal substantially.
embodiment 3congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament, is prepared from primarily of following bulk drugs: Herba Cistanches 11g, Fructus Ligustri Lucidi 5g, Radix Stephaniae Tetrandrae 6g, Herba Typhonii gigantei 6g, Herba speranskiae tuberculatae 8g, Rhizoma Acori Graminei 3.5g, Poria cum Radix Pini 7g, Poria 9g, Rhizoma Gastrodiae 5g, cattle rattan 4g, Radix Angelicae Sinensis 11g, Semen Litchi 5g, Rhizoma Alismatis 8g, Cacumen Securinegae Suffruticosae 4g, Fructus Aurantii Immaturus 4.5g.
The preparation method of Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing pharmacy particle agent is:
(1) by Herba Cistanches, Fructus Ligustri Lucidi, Poria cum Radix Pini, Rhizoma Gastrodiae, cattle rattan and Semen Litchi decontamination, cleaning, drying, pulverized 60 mesh sieves;
(2) by Radix Stephaniae Tetrandrae, Radix Angelicae Sinensis and Rhizoma Alismatis decontamination, clean, section, is placed in pot and makes popular, sprays the saline (mass ratio of salt and water is 30:1) of medical material weight 0.4 times, slow fire fried dry, and taking-up is dried in the air cool, for subsequent use;
(3) step (1), (2) made medical material are placed in non iron container with other residue medical material Herba Typhonii gigantei, Herba speranskiae tuberculatae, Rhizoma Acori Graminei, Poria, Cacumen Securinegae Suffruticosae together with Fructus Aurantii Immaturus, add the water soaking 2 hours of medical material weight 8 times, then big fire is boiled, and turns little fire and decocts 60 minutes, filter, collect filtrate;
(4) step (3) remaining filtering residue is watered, again decocts 30 minutes, filter, merge twice filtrate, be evaporated to 100ml, then add ethanol while stirring and make alcohol content reach 60%, leave standstill 21h, filter, being evaporated to relative density is 1.30(60 DEG C) clear paste, add pharmacy auxiliary material, dry, pulverize, obtain granule according to the preparation for processing of granule.
Model case: xxx, man, 3 years old.Father and mother stay out throughout the year, are with greatly by grandparents, and old man thinks that child belongs to the more late type of growth, too much do not worry that child grows problem, during rear upper kindergarten, teacher finds, child's reaction is slower, upper class hour is absent minded, and emotional instability talks incoherently, learning performance difficulty, just response situation with his family, after to look after children examination in hospital, final inspection is diagnosed as Congenital maldevelopment of brain.
Take the agent of the present embodiment gained Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing pharmacy particle, adopt twice daily, each one bag, about 5g, with warm boiled water, 30 days courses for the treatment of.Take after two months, child's altitude of intelligence improve, speech organizational capacity improve, learning capacity also improves, and continues to take three months, and child can concentrate on attending class, but study and motor capacity still slightly compared with normal child is poor.
embodiment 4congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament, is prepared from primarily of following bulk drugs: Herba Cistanches 14g, Fructus Ligustri Lucidi 7g, Radix Stephaniae Tetrandrae 7g, Herba Typhonii gigantei 9g, Herba speranskiae tuberculatae 10g, Rhizoma Acori Graminei 4.5g, Poria cum Radix Pini 8g, Poria 13g, Rhizoma Gastrodiae 7g, cattle rattan 5g, Radix Angelicae Sinensis 13g, Semen Litchi 8g, Rhizoma Alismatis 10g, Cacumen Securinegae Suffruticosae 5g, Fructus Aurantii Immaturus 5.5g.
The preparation method of Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament unguentum is:
(1) by Herba Cistanches, Fructus Ligustri Lucidi, Poria cum Radix Pini, Rhizoma Gastrodiae, cattle rattan and Semen Litchi decontamination, cleaning, drying, pulverized 60 mesh sieves;
(2) by Radix Stephaniae Tetrandrae, Radix Angelicae Sinensis and Rhizoma Alismatis decontamination, clean, section, is placed in pot and makes popular, sprays the saline (mass ratio of salt and water is 40:1) of quality of medicinal material 0.5 times, slow fire fried dry, and taking-up is dried in the air cool, for subsequent use;
(3) step (1), (2) made medical material are placed in non iron container with other residue medical material Herba Typhonii gigantei, Herba speranskiae tuberculatae, Rhizoma Acori Graminei, Poria, Cacumen Securinegae Suffruticosae together with Fructus Aurantii Immaturus, add the water soaking 2 hours of medical material weight 8 times, then big fire is boiled, and turns little fire and decocts 60 minutes, filter, collect filtrate;
(4) step (3) remaining filtering residue is watered, again decoct 40 minutes, filter, merge twice filtrate, then concentrating under reduced pressure is 1/3rd of original volume, adding ethanol while stirring makes alcohol content reach 60%, leave standstill 12h, filter, concentrating under reduced pressure is clear paste, relative density is 1.25(60 DEG C), obtain unguentum.
Model case: xxx, man, 24 months.Puerperal body index all are normal, but motion and development of speech slow compared with child of the same age, infant can come back for 3 months, within 9 months, can stand up, within 18 months, can sit by wall, within 24 months, still can not sit alone, stand, kneeling position can not be maintained and kneel row, both hands very flexible, head position controls bad, pronounce indistinctly, be diagnosed as Congenital maldevelopment of brain when 8 months, rehabilitation has no improvement always.
After being introduced, learn this formula, take the present embodiment gained Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament unguentum, adopt twice daily, each soup ladle, about 5-7g, with warm boiled water, 30 days courses for the treatment of.Take after two months, extremity are movable obviously to be improved, and can do meticulous activity, and the stability of action improves, independently can sit up, continue to take three months, take action sensitive, can link up with people, can be simple address, after half a year of taking medicine, infant body index recovers normal child's level.
embodiment 5congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament, is prepared from primarily of following bulk drugs: Herba Cistanches 12.5g, Fructus Ligustri Lucidi 6g, Radix Stephaniae Tetrandrae 6.5g, Herba Typhonii gigantei 7.5g, Herba speranskiae tuberculatae 9g, Rhizoma Acori Graminei 4g, Poria cum Radix Pini 7.5g, Poria 11g, Rhizoma Gastrodiae 6g, Niu Teng, 4.5g, Radix Angelicae Sinensis 12g, Semen Litchi 6.5g, Rhizoma Alismatis 9g Cacumen Securinegae Suffruticosae 4.5g, Fructus Aurantii Immaturus 5g.
The preparation method of Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament powder is:
(1) by Herba Cistanches, Fructus Ligustri Lucidi, Herba speranskiae tuberculatae, Poria cum Radix Pini, Rhizoma Gastrodiae, Niu Teng, Semen Litchi and Fructus Aurantii Immaturus decontamination, clean, 40 DEG C of freeze-day with constant temperature, then pulverized 150 mesh sieves;
(2) by Radix Stephaniae Tetrandrae, Radix Angelicae Sinensis and Rhizoma Alismatis decontamination, clean, section, is placed in pot and makes popular, sprays the saline (water and salt mass ratio are 30:1) of medical material weight 0.4 times, slow fire fried dry, and taking-up is dried in the air cool, pulverizes 180 mesh sieves, for subsequent use;
(3) get other residue medical material Herba Typhonii gigantei, Rhizoma Acori Graminei, Poria and Cacumen Securinegae Suffruticosae to be placed in non iron container, add the warm water soaking 1-2 hour of 55 DEG C of medical material weight 5 times, then big fire is boiled, and turns little fire and decocts 55 minutes, filter, collect filtrate;
(4) by the heating of step (3) filtrate, to be condensed into relative density be 1.33(60 DEG C) thick paste, then vacuum drying, pulverizes, and cross 200 mesh sieves, and mix with step (1), (2) made powder, sterilizing, is distributed into bag, obtains powder.
test example 1the clinical practice of embodiment 5 gained Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament powder: in March, 2011 in JIUYUE ,-2013, the patient that 212 examples are diagnosed as Congenital maldevelopment of brain is filtered out in 7 hospital-based outpatient pediatic clinics, wherein women 118 example, male 94 example, oldest 7 years old, minimal ages 4 months, 3.2 years old mean age.
Patient is divided into two groups at random, experimental group and matched group, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (P > 0.05), there is comparability.Experimental group takes embodiment 5 products obtained therefrom, take every day twice (warm), each 4-8g(adjusts to some extent depending on concrete condition), 30 days courses for the treatment of, matched group takes other medicine (conventional medication such as piracetam, Cerebrolysin Vial, ganglioside, mouse nerve growth factor, brain albumen).Period in a medicine carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect situation criterion: cure: level of intelligence and language organizational ability normal, flexibly, during action, action good stability, is emotionally stable, and has vigor, and physical growth developmental condition is as normal child of the same age in motion; Effective: level of intelligence significantly improves, can simply exchange, during motion, still some is slow and unstable in action, and learning capacity is poor, and emotion takes a turn for the better; Invalid: before and after taking, intelligence, language, physical handicaps are unchanged.Result is as shown in table 1.
Table 1 liang group patient treatment outcome
As shown in Table 1, after Drug therapy half a year, take the experimental group infant of embodiment 5 gained powder, what intelligence, language and motor capacity recovered substantially has 38 examples (25.7%), the infant that the state of an illness is clearly better has 100 examples (67.5%), and experimental group total effective rate is 93.2%.The total effective rate of matched group is 81.2%, and therapeutic effect is obviously not as matched group.
Compatibility of the present invention have selected kidney-replenishing, the Herba Cistanches of benefiting essence-blood; Liver and kidney tonifying, the Fructus Ligustri Lucidi of clearing away heat to improve acuity of vision; Drying dampness to eliminate phlegm, the Herba Typhonii gigantei of expellingging wind and relieving convulsion and Herba speranskiae tuberculatae; Ward off and dirtyly to have one's ideas straightened out, a surname's gas is by the Rhizoma Acori Graminei of expectorant; Mind tranquilizing and the heart calming, the Poria cum Radix Pini of promoting diuresis to eliminate damp pathogen, Poria and Rhizoma Alismatis; Endogenous wind stopping relieving convulsion, dispelling wind and removing obstruction in the collateral, the Rhizoma Gastrodiae of eliminating stasis to stop pain and cattle rattan; Expelling wind and activating blood circulation, the Cacumen Securinegae Suffruticosae of the strong muscle of kidney tonifying; Dispelling the stagnated QI removing food stagnancy, reduces phlegm except the Fructus Aurantii Immaturus of painful abdominal mass, and multiple medicines merges, and jointly plays intelligent promoting and the mind tranquilizing, expellings wind and relieving convulsion, effect of liver and kidney tonifying, thus has good curative effect to the cerebral dysgenesis infant that congenital factor deficiency causes.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament, is characterized in that, is prepared from primarily of following bulk drugs, be weight portion: Herba Cistanches 9-16, Fructus Ligustri Lucidi 3-9, Radix Stephaniae Tetrandrae 5-8, Herba Typhonii gigantei 5-10, Herba speranskiae tuberculatae 6-12, Rhizoma Acori Graminei 3-5, Poria cum Radix Pini 6-9, Poria 7-15, Rhizoma Gastrodiae 4-8, cattle rattan 3-6, Radix Angelicae Sinensis 9-15, Semen Litchi 4-9, Rhizoma Alismatis 6-12, Cacumen Securinegae Suffruticosae 3-6, Fructus Aurantii Immaturus 4-6.
2. Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament as claimed in claim 1, it is characterized in that, Herba Cistanches 11-14, Fructus Ligustri Lucidi 5-7, Radix Stephaniae Tetrandrae 6-7, Herba Typhonii gigantei 6-9, Herba speranskiae tuberculatae 8-10, Rhizoma Acori Graminei 3.5-4.5, Poria cum Radix Pini 7-8, Poria 9-13, Rhizoma Gastrodiae 5-7, cattle rattan 4-5, Radix Angelicae Sinensis 11-13, Semen Litchi 5-8, Rhizoma Alismatis 8-10, Cacumen Securinegae Suffruticosae 4-5, Fructus Aurantii Immaturus 4.5-5.5 is (preferred, Herba Cistanches 12.5, Fructus Ligustri Lucidi 6, Radix Stephaniae Tetrandrae 6.5, Herba Typhonii gigantei 7.5, Herba speranskiae tuberculatae 9, Rhizoma Acori Graminei 4, Poria cum Radix Pini 7.5, Poria 11, Rhizoma Gastrodiae 6, cattle rattan 4.5, Radix Angelicae Sinensis 12, Semen Litchi 6.5, Rhizoma Alismatis 9, Cacumen Securinegae Suffruticosae 4.5, Fructus Aurantii Immaturus 5).
3. the Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable powder, the preparation method of described powder is:
(1) by Herba Cistanches, Fructus Ligustri Lucidi, Herba speranskiae tuberculatae, Poria cum Radix Pini, Rhizoma Gastrodiae, Niu Teng, Semen Litchi and Fructus Aurantii Immaturus decontamination, clean, 40 DEG C of freeze-day with constant temperature, then 120-180 mesh sieve was pulverized (preferred, pulverized 140-160 mesh sieve, be more preferably, pulverized 150 mesh sieves);
(2) by Radix Stephaniae Tetrandrae, Radix Angelicae Sinensis and Rhizoma Alismatis decontamination, clean, section, is placed in pot and makes popular, sprays the saline of medical material weight 0.4 times, slow fire fried dry, and taking-up is dried in the air cool, pulverizes 180 mesh sieves, for subsequent use;
(3) getting other residue medical material Herba Typhonii gigantei, Rhizoma Acori Graminei, Poria and Cacumen Securinegae Suffruticosae is placed in non iron container, add the warm water soaking 1-2 hour of medical material weight 5 times, then big fire is boiled, turn little fire and decoct 30-80 minute (preferably, turn little fire and decoct 40-70 minute, be more preferably, turn little fire and decoct 55 minutes), filter, collect filtrate;
(4) by the heating of step (3) filtrate, to be condensed into relative density be 1.33(60 DEG C) thick paste, then vacuum drying, pulverizes, and cross 200 mesh sieves, and mix with step (1), (2) made powder, sterilizing, is distributed into bag, obtains powder.
4. Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament as claimed in claim 3, it is characterized in that, step (2) saline Zhong Shui and salt mass ratio are 30:1.
5. Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament as claimed in claim 3, is characterized in that, in step (3), warm water temperature is 40-65 DEG C (preferred, warm water temperature is 45-60 DEG C, is more preferably, and warm water temperature is 55 DEG C).
6. the Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable unguentum, the preparation method of described unguentum is:
(1) by Herba Cistanches, Fructus Ligustri Lucidi, Poria cum Radix Pini, Rhizoma Gastrodiae, cattle rattan and Semen Litchi decontamination, cleaning, drying, pulverized 60 mesh sieves;
(2) by Radix Stephaniae Tetrandrae, Radix Angelicae Sinensis and Rhizoma Alismatis decontamination, clean, section, is placed in pot and makes popular, sprays the saline (mass ratio of salt and water is 40:1) of quality of medicinal material 0.5 times, slow fire fried dry, and taking-up is dried in the air cool, for subsequent use;
(3) step (1), (2) made medical material are placed in non iron container with other residue medical material Herba Typhonii gigantei, Herba speranskiae tuberculatae, Rhizoma Acori Graminei, Poria, Cacumen Securinegae Suffruticosae together with Fructus Aurantii Immaturus, add the water soaking 2 hours of medical material weight 8 times, then big fire is boiled, turn little fire and decoct 40-80 minute (preferably, turn little fire and decoct 50-70 minute, be more preferably, turn little fire and decoct 60 minutes), filter, collect filtrate;
(4) be watered by step (3) remaining filtering residue, again decoct, filter, merge twice filtrate, then concentrating under reduced pressure is 1/3rd of original volume, adds ethanol while stirring and makes alcohol content reach 60%, leaves standstill 12h, and filter, concentrating under reduced pressure is clear paste, obtains unguentum.
7. Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament as claimed in claim 6, is characterized in that, step (4) decocts 30-50 minute (preferred, again to decoct 35-45 minute, be more preferably, again decoct 40 minutes) again.
8. Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament as claimed in claim 6, it is characterized in that, the relative density of step (4) clear paste is 1.20-1.30(60 DEG C) (preferred, the relative density of clear paste is 1.22-1.28, be more preferably, the relative density of clear paste is 1.25).
9. the Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament as described in as arbitrary in claim 1-2, is characterized in that, be made into pharmacy and attend class the granule accepted, the preparation method of described granule is:
(1) by Herba Cistanches, Fructus Ligustri Lucidi, Poria cum Radix Pini, Rhizoma Gastrodiae, cattle rattan and Semen Litchi decontamination, cleaning, drying, pulverized 60 mesh sieves;
(2) by Radix Stephaniae Tetrandrae, Radix Angelicae Sinensis and Rhizoma Alismatis decontamination, clean, section, is placed in pot and makes popular, sprays the saline (mass ratio of salt and water is 30:1) of medical material weight 0.4 times, slow fire fried dry, and taking-up is dried in the air cool, for subsequent use;
(3) step (1), (2) made medical material are placed in non iron container with other residue medical material Herba Typhonii gigantei, Herba speranskiae tuberculatae, Rhizoma Acori Graminei, Poria, Cacumen Securinegae Suffruticosae together with Fructus Aurantii Immaturus, add the water soaking 2 hours of medical material weight 8 times, then big fire is boiled, turn little fire and decoct 40-80 minute (preferably, turn little fire and decoct 50-70 minute, be more preferably, turn little fire and decoct 60 minutes), filter, collect filtrate;
(4) step (3) remaining filtering residue is watered, again decocts 30 minutes, filter, merge twice filtrate, be evaporated to 100ml, then add ethanol while stirring and make alcohol content reach 60%, leave standstill, filter, being evaporated to relative density is 1.30(60 DEG C) clear paste, add pharmacy auxiliary material, dry, pulverize, obtain granule according to the preparation for processing of granule.
10. Congenital maldevelopment of brain intelligent promoting and the mind tranquilizing medicament as claimed in claim 8, is characterized in that, it is preferred that step (4) leaves standstill 18-24h(, leaves standstill 20-22h, is more preferably, and leaves standstill 21h).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410673322.2A CN104324251A (en) | 2014-11-21 | 2014-11-21 | Intelligence-reinforcing and nerve-calming medicine for treating congenital atelencephalia and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410673322.2A CN104324251A (en) | 2014-11-21 | 2014-11-21 | Intelligence-reinforcing and nerve-calming medicine for treating congenital atelencephalia and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104324251A true CN104324251A (en) | 2015-02-04 |
Family
ID=52399141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410673322.2A Pending CN104324251A (en) | 2014-11-21 | 2014-11-21 | Intelligence-reinforcing and nerve-calming medicine for treating congenital atelencephalia and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104324251A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104587271A (en) * | 2015-02-11 | 2015-05-06 | 郭如英 | Educational medicine suitable for children with congenital mental deficiency and preparation |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02188528A (en) * | 1989-01-13 | 1990-07-24 | Tsurataka Tashiro | Remedy for dementia |
| CN1748774A (en) * | 2005-10-20 | 2006-03-22 | 北京阜康仁生物制药科技有限公司 | Brain tonifying preparation and new preparing method |
-
2014
- 2014-11-21 CN CN201410673322.2A patent/CN104324251A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02188528A (en) * | 1989-01-13 | 1990-07-24 | Tsurataka Tashiro | Remedy for dementia |
| CN1748774A (en) * | 2005-10-20 | 2006-03-22 | 北京阜康仁生物制药科技有限公司 | Brain tonifying preparation and new preparing method |
Non-Patent Citations (3)
| Title |
|---|
| 曹奕: "《张道宗临床治验》", 31 January 2010 * |
| 王文安: "《中医民间医术绝招（儿科部分）》", 31 January 1996 * |
| 虞林: "中医药治疗小儿弱智研究进展", 《中国中医药信息杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104587271A (en) * | 2015-02-11 | 2015-05-06 | 郭如英 | Educational medicine suitable for children with congenital mental deficiency and preparation |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102048933B (en) | Chinese medicinal composition for treating infantile diarrhea and preparation method thereof | |
| CN103751635A (en) | Traditional Chinese medicine mask for treating chloasma and preparation method thereof | |
| CN104398986A (en) | Tranquilization and brain tonifying epimedium herb oral liquid and preparation method thereof | |
| CN107952040A (en) | For nursing one's health the Chinese herbal ointment formula and its processing method of obstruction of the circulation of vital energy constitution | |
| CN103405728A (en) | Traditional Chinese medicine composition for treating climacteric syndrome and preparation method thereof | |
| CN103041256B (en) | Chinese herb preparation for curing recurrent respiratory tract infection of children | |
| CN103041257B (en) | Chinese materia medica preparation for curing high fever and respiratory tract infection of children | |
| CN103041255B (en) | Chinese materia medica preparation for curing swollen sore throat and respiratory tract infection of children | |
| CN102293964B (en) | Medicine for treating gastric ulcer, and preparation method thereof | |
| CN104397282A (en) | Tranquilization and brain tonifying eleutherococcus senticosus healthare tea and preparation method thereof | |
| CN104524479B (en) | A kind of Chinese medicine composition for treating premenstrual syndrome and preparation method thereof | |
| CN106822660A (en) | A kind of Chinese medicine preparation for treating cardiovascular and cerebrovascular disease | |
| CN106177651A (en) | A kind of infantile malnutrition medicine | |
| CN104324251A (en) | Intelligence-reinforcing and nerve-calming medicine for treating congenital atelencephalia and preparation method | |
| CN106177476A (en) | A kind of Hyperglycemic health care compositions comprising Herba Dendrobii and Pericarpium Citri Reticulatae | |
| CN103041258B (en) | Chinese materia medica preparation for curing respiratory tract infection with poor appetite of children | |
| CN105770773A (en) | Traditional Chinese medicinal preparation for treating adult mild brain disturbance and preparation method of traditional Chinese medicinal preparation | |
| CN104398849A (en) | Traditional Chinese medicine composition treating dizziness | |
| CN106177480A (en) | A kind of Hyperglycemic health care compositions comprising leaf of Cyclocarya paliurus Iljinskaja and Herba Dendrobii | |
| CN104547999A (en) | Oil for postpartum sweating | |
| CN104474300A (en) | Traditional Chinese medicine composition for treating congenital maldevelopment of brain and preparation method | |
| CN104366606A (en) | Gynecological healthcare crucian carp soup and preparation method thereof | |
| CN104367957A (en) | Marrow-tonifying and intelligence-improving preparation for treating cerebellar hypoplasia and preparation method thereof | |
| CN104306943A (en) | Traditional Chinese medicine combination for curing hyperlipidemia | |
| CN103041259B (en) | Chinese materia medica preparation for curing excessive phlegm, cough and respiratory tract infection of children |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: Deyang City, Sichuan Province, the Pearl River West Road 618000 Jingyang District No. 358 Applicant after: Hao Jianguo Address before: 250000 Shandong, Ji'nan Flyover District Normal Road, No. 46 Applicant before: Hao Jianguo |
|
| COR | Change of bibliographic data | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150204 |
|
| RJ01 | Rejection of invention patent application after publication |