JPH02188528A - Remedy for dementia - Google Patents
Remedy for dementiaInfo
- Publication number
- JPH02188528A JPH02188528A JP1006419A JP641989A JPH02188528A JP H02188528 A JPH02188528 A JP H02188528A JP 1006419 A JP1006419 A JP 1006419A JP 641989 A JP641989 A JP 641989A JP H02188528 A JPH02188528 A JP H02188528A
- Authority
- JP
- Japan
- Prior art keywords
- ratio
- radix
- rhizoma
- remedy
- dementia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010012289 Dementia Diseases 0.000 title abstract description 8
- 240000008397 Ganoderma lucidum Species 0.000 claims abstract description 7
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims abstract description 7
- 241000208340 Araliaceae Species 0.000 claims abstract description 4
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 4
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 4
- 235000008434 ginseng Nutrition 0.000 claims abstract description 4
- WTPPRJKFRFIQKT-UHFFFAOYSA-N 1,6-dimethyl-8,9-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione;1-methyl-6-methylidene-8,9-dihydro-7h-naphtho[1,2-g][1]benzofuran-10,11-dione Chemical compound O=C1C(=O)C2=C3CCCC(=C)C3=CC=C2C2=C1C(C)=CO2.O=C1C(=O)C2=C3CCC=C(C)C3=CC=C2C2=C1C(C)=CO2 WTPPRJKFRFIQKT-UHFFFAOYSA-N 0.000 claims description 2
- 244000132619 red sage Species 0.000 claims description 2
- 239000010015 huanglian Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 8
- 229940079593 drug Drugs 0.000 abstract description 8
- 239000000203 mixture Substances 0.000 abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 5
- 208000024827 Alzheimer disease Diseases 0.000 abstract description 2
- 208000013677 cerebrovascular dementia Diseases 0.000 abstract description 2
- 239000002904 solvent Substances 0.000 abstract description 2
- 239000004615 ingredient Substances 0.000 abstract 2
- 241000628997 Flos Species 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 210000000582 semen Anatomy 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 description 4
- 240000006079 Schisandra chinensis Species 0.000 description 3
- 235000008422 Schisandra chinensis Nutrition 0.000 description 3
- 235000007516 Chrysanthemum Nutrition 0.000 description 2
- 240000005250 Chrysanthemum indicum Species 0.000 description 2
- 244000000626 Daucus carota Species 0.000 description 2
- 235000002767 Daucus carota Nutrition 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 235000002789 Panax ginseng Nutrition 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 241001385733 Aesculus indica Species 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 241000222336 Ganoderma Species 0.000 description 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 229940124579 cold medicine Drugs 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 208000018316 severe headache Diseases 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 206010046885 vaginal cancer Diseases 0.000 description 1
- 208000013139 vaginal neoplasm Diseases 0.000 description 1
Abstract
Description
【発明の詳細な説明】 〔産業上の利用分野] 本発明は、痴呆症治療薬に関する。[Detailed description of the invention] [Industrial application field] The present invention relates to a drug for treating dementia.
[従来の技術]
痴呆症を治療する薬剤としては、種々のものが知られて
いる。しかしながら、副作用の点などから、まだ満足で
きるものはない6
漢方の処方の中に、「天王補心丹Jという処方があり、
これは中国元朝(600年以上前)時代の危亦林が撰し
た「凹入t!)処方」に社っている。[Prior Art] Various drugs are known for treating dementia. However, it is still not satisfactory in terms of side effects.6 Among the Chinese herbal prescriptions, there is a prescription called ``Tenno Shushintan J''.
This is based on the ``concave t!'' formula written by Kiyalin during the Yuan Dynasty (more than 600 years ago) in China.
しかしながら、この処方の効能は、単に不安、不眠、心
悸7’C進の治療に用いられるものとされているに過ぎ
ず、その上載が国では殆ど知られていない。However, the efficacy of this prescription is merely that it is used to treat anxiety, insomnia, and heart palpitations, and its use is hardly known in Japan.
また、′fA方処方は、その構成成分の分量比を僅かに
変更するだけで1作用が一変する場合がある。Further, in the 'fA prescription, one effect may be completely changed by slightly changing the proportions of the constituent components.
−例を挙げれば2桂枝湯(桂枝4.勾薬4、大炎4、生
姿4.甘草1)は、最も穏やかな感冒に対する薬剤とし
て知られているが、このなかの桂枝の量を2倍にすれば
、感冒上熱後の激しい頭痛に効き(桂枝加桂湯)、また
巧薬の盆を2倍にすると、全く国保のないと思われる膣
癌、下痢に有効となる(桂枝加/j薬i!))。-For example, 2 Keishito (4 Keishi, 4 Koyaku, 4 Dain, 4 Raw form, 1 Licorice) is known as the mildest cold medicine. If you double the amount, it will be effective against severe headaches after a cold or fever (Keishikakeito), and if you double the amount of Takuyaku no Bon, it will be effective against vaginal cancer and diarrhea, which are not covered by the National Health Insurance. Naru (Keishika/jyakui!)).
[発明の概要]
本発明者は、前記の「天王補心丹Jの構成を補正して痴
呆症に有効な処方を見いだした。[Summary of the Invention] The present inventor corrected the composition of the above-mentioned "Tenno Shushintan J" and found a prescription effective for dementia.
即ち5本発明は、桔梗(1)、五味子(1,7)、天門
冬(2)、麦門冬(3)、遠志(2)、酸棗仁(3)、
栢子仁(1,7)、石富根(3)、人参(3)、玄参(
3)、丹参(2)、当帰 (2)、地黄(2)、茨苓(
3)、黄連(1)、釣藤(3)、菊花 (1,7)及び
霊芝(1,7)(但し括弧内の数字は重量比を表わす)
よりなる痴呆症治療薬に関する。That is, 5 of the present invention includes Kikyo (1), Schisandra (1, 7), Tenmon Fuyu (2), Mugimon Fuyu (3), Toshi (2), Sakuzu Hitoshi (3),
Kayako Hitoshi (1,7), Ishitomine (3), Ginseng (3), Genseng (
3), Dansin (2), Toki (2), Jihuang (2), Ibarei (
3), Oren (1), Chowister (3), Kikuka (1, 7), and Reishi (1, 7) (however, the numbers in parentheses indicate the weight ratio)
More about dementia treatment drugs.
本発明の薬剤では、11「記の成分の混合物を溶媒例え
ば水により抽出して経口投与するのが好ましい0例えば
、桔梗(1)、五味子(1,7)、天門冬(2)1麦門
冬(3)、遠志(2)、酸棗仁(3)、栢子仁(1,,
7)=石菖根(3)1人参(3)、玄参(3)、丹参(
2)、当帰 (2)。In the drug of the present invention, it is preferable to extract a mixture of the following components with a solvent such as water and administer orally. Fuyu (3), Toshi (2), Hitoshi Suzatsu (3), Hitoshi Kayakko (1,,
7) = Stone iris (3) 1 Ginseng (3), Genseng (3), Danseng (
2), Toki (2).
地黄(2)、茨苓(3)、黄連(1)、釣藤 (3)、
#花 (1,7)及び霊芝(1,7) (但し括弧
内の数字は重量比を表す)の細切した混合物を容器に入
れ、混合物1重量当たり10〜20倍の6址の水を注ぎ
、加熱して半量に煮つめ。Jihuang (2), Thornberry (3), Huangren (1), Chowisteria (3),
# Put a mixture of shredded flowers (1, 7) and Reishi (1, 7) (however, the numbers in parentheses indicate the weight ratio) into a container, and add 10 to 20 times the amount of water per 1 weight of the mixture. Pour, heat, and reduce to half.
濾過し、得られた濾液を用いる。又は、得られた濾液か
ら水分を除いて固体の活性成分を取得し。Filter and use the obtained filtrate. Alternatively, the solid active ingredient is obtained by removing water from the obtained filtrate.
この活性成分をそのまま、又は常法により経口投与の形
例えば顆粒又は粉末、錠剤の形にして用いることができ
る。The active ingredient can be used as it is or in the form of oral administration, such as granules, powder, or tablets, by conventional methods.
本発明の薬剤の成人に対する1日量は、桔梗1区、五味
子1.7g、天門冬2g1表門麦門g。The daily dose of the drug of the present invention for adults is Kikyo 1 ward, Schisandra 1.7 g, Tenmon Fuyu 2 g, Omotemon Mugimon g.
遠志2g、酸棗仁3g、栢子仁1.7g、石富根3に、
人参3g、玄参3g、丹参2に、当帰ZX。Toshi 2g, Sansatsu Jin 3g, Kayako Jin 1.7g, Ishitomine 3,
3g of carrots, 3g of red ginseng, 2 g of red ginseng, and Toki ZX.
地黄2g、萩苓3g、黄連1g、釣m3g、菊花1.7
g及び霊芝1.7gの混合物から前述の ようにして抽
出したものである。そして、これを10に2又は3回に
分けて服用する。Jihuang 2g, Hagirei 3g, Oren 1g, Tsurim 3g, Chrysanthemum 1.7
It was extracted as described above from a mixture of 1.7 g of ganoderma and 1.7 g of reishi. Then, take this in 2 or 3 doses every 10 days.
本発明の薬剤が有効な痴呆症としては1例えばアルツハ
イマー型及び脳血管性の痴呆症が挙げられる0本発明の
薬剤は、これら疾患に対して、有害な副作用を示すこと
なしに比較的短い期間に著効を示す。Dementias for which the drug of the present invention is effective include 1 For example, Alzheimer's disease and cerebrovascular dementia. showed significant effects.
本発明の薬剤には、前記の使用範囲において毒性は認め
られない。The drug of the present invention has no toxicity within the above range of use.
[実施例] 次に、実施例を示す。[Example] Next, examples will be shown.
実施例 1
桔梗1g、五味子1.7g、天門冬2g、麦門冬3に、
遠志2に、酸棗仁3稟、栢子仁1.7g。Example 1 Kikyo 1g, Schisandra 1.7g, Tenmonfuyu 2g, Mugimonfuyu 3,
Toshi 2, sour date 3 yen, and pyokko 1.7g.
石菖根3g、人参3g、玄参3g、丹参2に、当帰2区
、地黄2露會茨苓3g、黄連XZ、釣113g、菊花1
.7.及び霊芝1.7gの細切した混合物(合計39.
8g)を容器に入れ、これに水 600ccを注いだ、
容器を約1時間加熱し、水の量を半分にした。内容物を
濾過し濾液を得た。Iris root 3g, Carrot 3g, Genseng 3g, Danshen 2, Toki 2ku, Jiang 2rohuai tsubara 3g, Oriental XZ, Fish 113g, Chrysanthemum 1
.. 7. and 1.7 g of shredded Reishi mushroom mixture (total 39.
8g) in a container and poured 600cc of water into it.
The container was heated for about an hour and the amount of water was halved. The contents were filtered to obtain a filtrate.
実施例 2
76オの女性、アルツハイマー型痴呆、主訴として、心
臓が悪く、血圧が上下に変動し、膀胱が悪く、下痢し易
く1食欲不振であって、−人で出歩く、実施例1で得た
濾液を1日量とし、1日にこれを2回に分けて服用した
。6箇月後には、−人で出歩くこともなく、血圧も一定
となった。Example 2 A 76-year-old woman had Alzheimer's type dementia. Her chief complaints were heart problems, fluctuating blood pressure, bladder problems, easy diarrhea, and poor appetite. The filtrate was taken as a daily dose, and this was divided into two doses per day. After 6 months, I no longer went out with other people and my blood pressure became stable.
Claims (1)
冬(3)、遠志(2)、酸棗仁(3)、栢子仁(1.7
)、石菖根(3)、人参(3)、玄参(3)、丹参(2
)、当帰(2)、地黄(2)、茯苓(3)、黄連(1)
、釣藤(3)、菊花(1.7)及び霊芝(1.7)(但
し括弧内の数字は重量比を表す)よりなる痴呆症治療薬
。Kikyo (1), Gomiko (1.7), Tenmon Fuyu (2), Mugimon Fuyu (3), Toshi (2), Sukazu Hitoshi (3), Kayako Hitoshi (1.7)
), Iris root (3), Ginseng (3), Genseng (3), Danshen (2)
), Dangki (2), Jihuang (2), Bouling (3), Huanglian (1)
, Tsuriofuji (3), Kikuka (1.7), and Reishi (1.7) (however, the numbers in parentheses represent the weight ratio).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1006419A JPH02188528A (en) | 1989-01-13 | 1989-01-13 | Remedy for dementia |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1006419A JPH02188528A (en) | 1989-01-13 | 1989-01-13 | Remedy for dementia |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH02188528A true JPH02188528A (en) | 1990-07-24 |
Family
ID=11637852
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1006419A Pending JPH02188528A (en) | 1989-01-13 | 1989-01-13 | Remedy for dementia |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH02188528A (en) |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04275224A (en) * | 1991-03-02 | 1992-09-30 | Kissei Pharmaceut Co Ltd | Therapeutic agent for dementia |
KR20000002474A (en) * | 1998-06-20 | 2000-01-15 | 신민규 | Preventive and therapeutic agent for degenerative cerebrum neurological disease |
WO2002094302A1 (en) * | 2001-05-23 | 2002-11-28 | Gil-Ja Jhon | Compositions comprising extract of ganoderma lucidum, oleamide and its structural analogue as an effective component for preventing or treating dementia |
WO2003006038A1 (en) * | 2001-07-10 | 2003-01-23 | Regen Biotech, Inc. | A composition for the protection and regeneration of nerve cells containing the extract of coptidis rhizoma |
KR100378735B1 (en) * | 2000-05-03 | 2003-03-31 | 주식회사 브레인트로피아 | The method for extraction and purification of ingredients from Polygala tenufolia and its extracts containing therapeutic composite for dementia |
KR20040023197A (en) * | 2002-09-11 | 2004-03-18 | 백일성 | Phamaceutical use for treating Alzheimer of composition comprising, as main ingredients, Aurantii Nobilis Pericarpium, Hoelen, Ligusticum acutilobum, Uncariae Ramulus et Uncus, Acorus gramineus, Atractyodis Rhizoma, Angelica dahurica, Zizyphi Spinosi Semen, Rehmanniae Radix Preparata, Cornus officinalis, Polygala tenuifolia pharmaceutical preparations containing them |
KR20040023196A (en) * | 2002-09-11 | 2004-03-18 | 백일성 | Phamaceutical composition for treating Alzheimer comprising, as main ingredients, Aurantii Nobilis Pericarpium, Hoelen, Ligusticum acutilobum, Uncariae Ramulus et Uncus, Acorus gramineus, Atractyodis Rhizoma, Angelica dahurica, Zizyphi Spinosi Semen, Rehmanniae Radix Preparata, Cornus officinalis and Polygala tenuifolia |
JP2005501018A (en) * | 2001-06-15 | 2005-01-13 | コリア リサーチ インスティチュート オブ ケミカル テクノロジー | Use of Kyokyo extract for prevention and treatment of degenerative brain disease, or for enhancing memory |
KR100481684B1 (en) * | 2001-12-28 | 2005-04-07 | 주식회사 엘컴사이언스 | Preventives and remedies of neurodegenerative disease containing pinusolide derivatives as active ingredients |
KR100490315B1 (en) * | 2002-05-07 | 2005-05-17 | 주식회사 한생화장품 | Uncaria sinensis extract showing anti-aging effect on cells and cosmetics comprising the same |
KR100502835B1 (en) * | 2001-05-23 | 2005-07-20 | 전길자 | Compositions comprising extract of ganoderma lucidum, oleamide and its structural analogue as an effective component for preventing or treating dementia |
JP2005350391A (en) * | 2004-06-10 | 2005-12-22 | Noevir Co Ltd | Prophylactic/therapeutic agent for alzheimer's disease |
US7138427B2 (en) | 1999-03-26 | 2006-11-21 | Phytopharm Plc. | 5-β-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia |
KR100744015B1 (en) * | 2006-03-06 | 2007-07-30 | 길기정 | Health drink for dementia prevention using a chinese medicine |
CN104324251A (en) * | 2014-11-21 | 2015-02-04 | 郝建国 | Intelligence-reinforcing and nerve-calming medicine for treating congenital atelencephalia and preparation method |
-
1989
- 1989-01-13 JP JP1006419A patent/JPH02188528A/en active Pending
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04275224A (en) * | 1991-03-02 | 1992-09-30 | Kissei Pharmaceut Co Ltd | Therapeutic agent for dementia |
US7507720B2 (en) | 1998-03-26 | 2009-03-24 | Phytopharm Plc | 5-Beta-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia |
KR20000002474A (en) * | 1998-06-20 | 2000-01-15 | 신민규 | Preventive and therapeutic agent for degenerative cerebrum neurological disease |
US7138427B2 (en) | 1999-03-26 | 2006-11-21 | Phytopharm Plc. | 5-β-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia |
KR100378735B1 (en) * | 2000-05-03 | 2003-03-31 | 주식회사 브레인트로피아 | The method for extraction and purification of ingredients from Polygala tenufolia and its extracts containing therapeutic composite for dementia |
KR100502835B1 (en) * | 2001-05-23 | 2005-07-20 | 전길자 | Compositions comprising extract of ganoderma lucidum, oleamide and its structural analogue as an effective component for preventing or treating dementia |
WO2002094302A1 (en) * | 2001-05-23 | 2002-11-28 | Gil-Ja Jhon | Compositions comprising extract of ganoderma lucidum, oleamide and its structural analogue as an effective component for preventing or treating dementia |
JP2005501018A (en) * | 2001-06-15 | 2005-01-13 | コリア リサーチ インスティチュート オブ ケミカル テクノロジー | Use of Kyokyo extract for prevention and treatment of degenerative brain disease, or for enhancing memory |
WO2003006038A1 (en) * | 2001-07-10 | 2003-01-23 | Regen Biotech, Inc. | A composition for the protection and regeneration of nerve cells containing the extract of coptidis rhizoma |
KR100481684B1 (en) * | 2001-12-28 | 2005-04-07 | 주식회사 엘컴사이언스 | Preventives and remedies of neurodegenerative disease containing pinusolide derivatives as active ingredients |
KR100490315B1 (en) * | 2002-05-07 | 2005-05-17 | 주식회사 한생화장품 | Uncaria sinensis extract showing anti-aging effect on cells and cosmetics comprising the same |
KR20040023197A (en) * | 2002-09-11 | 2004-03-18 | 백일성 | Phamaceutical use for treating Alzheimer of composition comprising, as main ingredients, Aurantii Nobilis Pericarpium, Hoelen, Ligusticum acutilobum, Uncariae Ramulus et Uncus, Acorus gramineus, Atractyodis Rhizoma, Angelica dahurica, Zizyphi Spinosi Semen, Rehmanniae Radix Preparata, Cornus officinalis, Polygala tenuifolia pharmaceutical preparations containing them |
KR20040023196A (en) * | 2002-09-11 | 2004-03-18 | 백일성 | Phamaceutical composition for treating Alzheimer comprising, as main ingredients, Aurantii Nobilis Pericarpium, Hoelen, Ligusticum acutilobum, Uncariae Ramulus et Uncus, Acorus gramineus, Atractyodis Rhizoma, Angelica dahurica, Zizyphi Spinosi Semen, Rehmanniae Radix Preparata, Cornus officinalis and Polygala tenuifolia |
JP2005350391A (en) * | 2004-06-10 | 2005-12-22 | Noevir Co Ltd | Prophylactic/therapeutic agent for alzheimer's disease |
JP4698167B2 (en) * | 2004-06-10 | 2011-06-08 | 株式会社ノエビア | Alzheimer's disease prevention and treatment |
KR100744015B1 (en) * | 2006-03-06 | 2007-07-30 | 길기정 | Health drink for dementia prevention using a chinese medicine |
CN104324251A (en) * | 2014-11-21 | 2015-02-04 | 郝建国 | Intelligence-reinforcing and nerve-calming medicine for treating congenital atelencephalia and preparation method |
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