CN104306168B - Application of N-(4-chloro-2,5-dimethoxyphenyl)-5-isopropyl-2-methoxybenzenesulfonamide in promotion of hair growth - Google Patents
Application of N-(4-chloro-2,5-dimethoxyphenyl)-5-isopropyl-2-methoxybenzenesulfonamide in promotion of hair growth Download PDFInfo
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- CN104306168B CN104306168B CN201410545572.8A CN201410545572A CN104306168B CN 104306168 B CN104306168 B CN 104306168B CN 201410545572 A CN201410545572 A CN 201410545572A CN 104306168 B CN104306168 B CN 104306168B
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Abstract
The invention discloses an application of N-(4-chloro-2,5-dimethoxyphenyl)-5-isopropyl-2-methoxybenzenesulfonamide in preparation of composition for promoting hair growth. The N-(4-chloro-2,5-dimethoxyphenyl)-5-isopropyl-2-methoxybenzenesulfonamide is capable of promoting hair follicles to transform from a resting stage to a growing stage, has effects of starting and remarkably promoting hair growth, is quick in response and remarkable in effect, can be used for preparing medicines or cosmetics for treating alopecia or promoting hair growth, and has wide application prospect and value.
Description
Technical field
The present invention relates to life medicine technology field, and in particular to a kind of hair accelerator (nitrogen-(chloro- 2, the 5- dimethoxies of 4-
Base phenyl) -5- isopropyl -2- methoxybenzenesulphoismides) and combinations thereof and its promote hair growth in application.
Background technology
Alopecia problem is the puzzlement of current many people, has various the reason for cause pathologic alopecia, at present clinically the most
Main includes：Alopecia caused by alopecia, stress that the gene defect of inborn genetic, chemotherapy cause, and male swashs
Plain source property alopecia (AGA), that is, our bald phenomenons of common male, this hormonal alopecia also often have hair in women
It is raw.
Though the medicine of the prevention and treatment alopecia sold in the market is more, including some have the life of the title of Chinese herbal and crude drugs preparations
Hair agent, but pure Chinese herbal medicine preparation effect is not very good.And be used for trichogenous compound monomer mainly or pass through
The minoxidil that FDA is approved, from its purposes is developed in one's early years so far, its mechanism of action is not still very clear, it means that its
Using comprising certain potential safety hazard, while being also impossible to be applied to all patients.The chemical combination of other treatment androgenic alopecia
Thing monomer also has antiandrogen medicine RU58841, Finasteride, oral estrogen class medicine and Tretinoin, otherwise but these medicines
Recurrent is high, otherwise the rate that takes effect is low.In view of above-mentioned a variety of, it is very necessary to find a kind of more effective safer hair tonic medicament.
The content of the invention
The invention provides a kind of new hair growth promoting agents nitrogen-(chloro- 2, the 5- Dimethoxyphenyls of 4-) -5- isopropyls
Base -2- methoxybenzenesulphoismides and the composition containing the compound (including educate hair, Anti-hair loss effectively facilitating hair growth
Deng) in application.Hair growth is periodic, is divided into growth period, catagen and resting stage.The immediate cause of most of alopecias
It is that imbalance, resting stage extension and the growth period of hair cycle shorten, the hair of growth is not enough to make up missing, thus makes
Into the situation of oligotrichosis.
Present invention firstly provides the nitrogen shown in formula (I)-(chloro- 2, the 5- Dimethoxyphenyls of 4-) -5- isopropyl -2- methoxies
Application of the base benzsulfamide in trichogenous composition is prepared,
Formula (I).
Nitrogen-(chloro- 2, the 5- Dimethoxyphenyls of 4-) -5- isopropyl -2- methoxybenzenesulphoismides, (N- shown in formula (I)
(4-chloro-2,5-dimethoxyphenyl) -5-isopropyl-2-methoxybenzenesulfonamide), its change
Formula： C18H22ClNO5S；Molecular weight：399.89.
In the present invention, the compound nitrogen-(chloro- 2, the 5- Dimethoxyphenyls of 4-) -5- isopropyl -2- methoxybenzene sulphonyl
Amine can be obtained by conventional chemical synthesis process, can also be bought by the market and obtained.
In the present invention, it refers to the growth and elongation for promoting chaeta to include hair to promote hair growth；It is trichogenous
Implication is also including educating hair and Anti-hair loss etc..
In the present invention, the composition includes pharmaceutical composition, food, health products or cosmetics.The agent of the composition
Type includes：Lotion, bath agent, liniment, tincture, finish, creme, ointment, emplastrum, paste, emplastrum, paster, plastics, film
Agent, gel, cataplasm, application, spray, aerosol, implant, emulsion, shampoo, hair conditioner, suppository, tablet, capsule,
Pill, injection, pulvis etc..
In the present invention, counted on the basis of the gross weight of composition, formula (I) the compound nitrogen-(chloro- 2, the 5- dimethoxies of 4-
Base phenyl) -5- isopropyl -2- methoxybenzenesulphoismides content in the composition be 0.001~99.9%.Preferably, content
It is 0.01~90%.It is highly preferred that content is 0.01%~10%.Preferably, it is 0.01%~1% mass concentration.
In the present invention, active material of the composition also containing other preventions and/or hair growth, including it is not limited to rice
Promise ground that, estrogen, antisterone, cyproterone acetate, Finasteride, Epristeride, dutasteride, Tretinoin, RU58841.
In the present invention, the compound nitrogen-(chloro- 2, the 5- Dimethoxyphenyls of 4-) -5- isopropyl -2- methoxybenzene sulphonyl
Amine is also used as additive form and uses, then is deployed into tincture, creme, ointment, emulsion, patch etc. with corresponding auxiliary material
Deng the problems such as treating and preventing baldness and hypotrichosis, it is adaptable to partial smearing and percutaneous dosing.
The invention allows for a kind of composition, it contains：Formula (I) the compound nitrogen of effective dose-(chloro- 2, the 5- diformazans of 4-
Phenyl) -5- isopropyl -2- methoxybenzenesulphoismides；And, pharmaceutically acceptable carrier, food, health products or cosmetic
Product acceptable carrier.
The invention allows for a kind of composition, it contains：Formula (I) the compound nitrogen of effective dose-(chloro- 2, the 5- diformazans of 4-
Phenyl) -5- isopropyl -2- methoxybenzenesulphoismides；Pharmaceutically acceptable carrier, food, health products or cosmetics can
The carrier of receiving；And, the active material of one or more other prevention and/or hair growth.
Further, the present composition can also add surfactant, skin penetration enhancer, preservative, antioxygen
The auxiliary materials such as agent, NMF, essence, spices.
In the present invention, effective dose can produce function or activity to people and/or animal and can be connect by people and/or animal
The amount received.Pharmaceutically acceptable carrier refers to various excipient and diluent, known to those skilled in the art to know.
In the present invention, formula (I) compound nitrogen-(chloro- 2, the 5- Dimethoxyphenyls of 4-) -5- isopropyl -2- methoxybenzene sulphurs
Acid amides active component accounts for the 0.001~99.9% of composition total mass concentration.Preferably 0.01~90%.Preferably, content
It is 0.01%~10%.Preferably 0.01%~1% mass concentration.Surplus is pharmaceutically acceptable carrier or other add
Plus agent etc..
In the present invention, the carrier in the composition includes oleaginous base or water-soluble base.The oleaginous base
Including vaseline, vegetable oil, paraffin, silicone oil, hydrogenated vegetable oil, triglyceride, stearic acid, hexadecanol, acetone, petroleum ether,
Ethyl oleate etc..The water-soluble base includes water, distilled water, glycerine, gelatin, xanthan gum, shitosan, Methyl cellulose
Element, polyethylene glycol etc..In the present invention, the active material of described other preventions and/or hair growth includes being not limited to minot ground
That, estrogen, antisterone, cyproterone acetate, Finasteride, Epristeride, dutasteride, Tretinoin, RU58841.
Present invention also offers a kind of hair accelerator, compound nitrogen shown in the formula (I) that it contains effective dose-(4- chloro- 2,
5- Dimethoxyphenyls) -5- isopropyl -2- methoxybenzenesulphoismides.The hair accelerator can further include a kind of or many
Plant pharmaceutically acceptable carrier, food, health products or cosmetically acceptable carrier.Can also further include one or more
Other preventions and/or the active material of hair growth.One or more surfactant, Transdermal absorption can be also further added to promote
Enter the auxiliary materials such as agent, preservative, antioxidant, NMF, essence, spices.In the hair accelerator, formula (I) compound nitrogen-(4-
Chloro- 2,5- Dimethoxyphenyls) -5- isopropyl -2- methoxybenzenesulphoismides active component content be mass concentration 0.001~
99.9%.Preferably 0.01~90%.Preferably, content is 0.01%~10%.Preferably 0.01%~1% mass is dense
Degree.
Nitrogen-(chloro- 2, the 5- Dimethoxyphenyls of 4-) -5- isopropyl -2- methoxybenzenes are utilized present invention also offers one kind
The trichogenous method of sulfonamide or the composition containing the compound.Methods described promotes hair follicle from resting stage to life
Convert for a long time, promote the increase of hair follicle quantity.In a specific embodiment, by nitrogen-(chloro- 2, the 5- Dimethoxyphenyls of 4-)-
5- isopropyl -2- methoxybenzenesulphoismides or the composition containing the compound are applied to the hair follicle portion in hair resting stage
Position, test result indicate that hair follicle is converted from resting stage to growth period.In a specific embodiment, by nitrogen-(4- chloro- 2,5-
Dimethoxyphenyl) -5- isopropyl -2- methoxybenzenesulphoismides or the composition containing the compound be applied to hair follicle position,
Test result indicate that hair follicle quantity is dramatically increased.
Present invention also offers a kind of beauty method of non-treatment purpose, methods described includes giving subject effective amounts
Nitrogen-(chloro- 2, the 5- Dimethoxyphenyls of 4-) -5- isopropyl -2- methoxybenzenesulphoismides given birth to the hair for promoting the object
It is long.The object including the mankind, tool hair animal including being not limited to horse, dog, cat etc..
Present invention also offers it is a kind of prevent and/or hair growth method, giving needs prevention and/or hair growth
The nitrogen of subject effective amounts-(chloro- 2, the 5- Dimethoxyphenyls of 4-) -5- isopropyl -2- methoxybenzenesulphoismides.The object
Including the mankind, has the animal of hair including being not limited to horse, dog, cat etc..
In a specific embodiment, (such as 1 time, 3 times or 5 times) are carried out one or more times a day and apply nitrogen of the present invention-(4-
Chloro- 2,5- Dimethoxyphenyls) -5- isopropyl -2- methoxybenzenesulphoismides or the present composition.It is of the invention can also and its
His Chinese herbal medicine or Western medicine or biological regulator or other treatment method etc. are co-administered.
In a specific embodiment, the present invention can be applied on the hair position such as scalp of the object such as mankind.
In a specific embodiment, the present invention can be applied to the object of hypotrichosis, trichomadesis.
Present invention also offers nitrogen-(chloro- 2, the 5- Dimethoxyphenyls of 4-) -5- isopropyl -2- methoxybenzenesulphoismides or
Application of the composition containing the compound in promoting hair follicle to be converted from resting stage to growth period.Present invention also offers nitrogen-
(chloro- 2, the 5- Dimethoxyphenyls of 4-) -5- isopropyl -2- methoxybenzenesulphoismides or the composition containing the compound are promoting
Application in hair follicle increasing number.
Present invention firstly discloses nitrogen-(chloro- 2, the 5- Dimethoxyphenyls of 4-) -5- isopropyl -2- methoxybenzenesulphoismides
Trichogenous method and application, it promotes hair follicle to be converted from resting stage to growth period, promotes hair follicle increasing number, has
Start and trichogenous effect, rapid-action and effect is significant, the aspect such as speed, area, quality for hair growth
Effect is remarkably promoted, and is had no toxic side effect, can be used to safely promote hair growth.With the minoxidil on existing market
Tincture (Man Di) compares, and application effect of the present invention is more notable.The present invention is provided for the treatment of alopecia clinical prevention, beauty and health care etc.
New approach, can be applied to prepare hair growth or promotees medicine or cosmetics of hair growth etc..The present invention is also suitable with addition
Dosage form formula is used, and tincture, creme, ointment, emulsion, patch etc. are deployed into corresponding auxiliary material, for treatment and/or in advance
Anti-hair loss disease and hair sparse etc., are applicable to partial smearing and percutaneous dosing, can substantially promote natural on-off cycles of hair growth.The present invention has wide
General application prospect, important social effect and economic worth.
Brief description of the drawings
Fig. 1 shows that the compounds of this invention starts the influence of growth to experiment mice hair follicle resting stage (42 days) hair.
Fig. 2 shows that the compounds of this invention starts the shadow after growing 14 days to experiment mice hair follicle resting stage (55 days) hair
Ring.
Fig. 3 shows that the compounds of this invention starts the influence of the skin follicle form of growth 14 days to experiment mice hair.
Specific embodiment
With reference to specific examples below and accompanying drawing, the present invention is described in further detail, protection content of the invention
It is not limited to following examples.Under the spirit and scope without departing substantially from inventive concept, those skilled in the art it is conceivable that change
Change and advantage is all included in the present invention, and with appending claims as protection domain.Implement process of the invention,
Condition, reagent, experimental technique etc., in addition to the following special content for referring to, are the universal knowledege and common knowledge of this area,
The present invention is not particularly limited content.
The invention provides nitrogen-(chloro- 2, the 5- Dimethoxyphenyls of 4-) -5- isopropyl -2- methoxybenzenesulphoismides or contain
There is new application of the compound as the composition of active component in hair growth is promoted.Nitrogen of the present invention-(chloro- 2, the 5- bis- of 4-
Methoxyphenyl) -5- isopropyl -2- methoxybenzenesulphoismides or containing the compound as active component composition, stimulate
The generation of hair follicle growth phase, reduces the delay in resting stage, improves local blood circulation, realizes preventing and treating alopecia, promotes new setation
Grow.
Embodiment 1
This experiment studies compound nitrogen-(chloro- 2,5- dimethoxy benzenes of 4- with C57BL/6 Strains of Mouse as experimental subjects
Base) -5- isopropyl -2- methoxybenzenesulphoismides (that is, formula (I) compound) to promotion from mouse hair resting stage to growth period make
With.
Choose the brood female mice being born on the same day and (take 42 days, P42 ages in days after being born here in early stage hair resting stage
Mouse) do back shaving with electric shaver and process.Then it is divided into three groups, every group of 3 mouse.(1) negative control group：Daily
Every mouse back smears the basic cream 0.1g of blank.(2) positive controls：Daily every mouse back smears commercially available minot
Your tincture (Man Di, minoxidil content 5%) 100 μ l of ground；(3) experimental group：Daily every mouse back smears test medicine 0.1g.
Timing is recorded and shot to mouse back hair growth situation.Every group of mouse setation situation is with coating process time (from painting
Medicine the 0th day to the 14th day) situation of change, as shown in Figure 1.
Wherein, the formula of blank basis cream is every 100 grams and contains：78.8 grams of water, 6 grams of glycerine, EDETATE SODIUM 0.1
Gram, cetostearyl alcohol：0.8 gram, 4.0 grams of carbonic acid dioctyl ester, 3.0 grams of caprylic capric glyceryl ester, 4.0 grams of White Mineral Oil, stearyl alcohol
- 211.0 grams of ether, -21.0 grams of stearic alcohol ether, 0.8 gram of 13/ polyisobutene of polyacrylic acid/TWEEN-20, Phenoxyethanol 0.3
Gram, 0.2 gram of methyl hydroxybenzoate.
Wherein, the test medicine refers to that formula (I) compound and blank basis cream are prepared into the preparation to be formed, and it contains formula
(I) amount of compound is 0.06%.The formula of test medicine is every 100 grams and contains：78.74 grams of water, 6 grams of glycerine, EDETATE SODIUM 0.1
Gram, cetostearyl alcohol：0.8 gram, 4.0 grams of carbonic acid dioctyl ester, 3.0 grams of caprylic capric glyceryl ester, 4.0 grams of White Mineral Oil, stearyl alcohol
- 211.0 grams of ether, -21.0 grams of stearic alcohol ether, 0.8 gram of 13/ polyisobutene of polyacrylic acid/TWEEN-20, Phenoxyethanol 0.3
Gram, 0.2 gram of methyl hydroxybenzoate, formula (I) compound nitrogen-(chloro- 2, the 5- Dimethoxyphenyls of 4-) -5- isopropyl -2- methoxybenzene sulphurs
0.06 gram of acid amides.
The hair growth of the mouse in hair resting stage remains static, and can not be grown immediately after shaving, need to wait until
Next hair follicle growth phase triggering could grow, sustainable more than three weeks on this section of resting stage time theory.Reality as shown in Figure 1
Test that result is visible, the mouse of experimental group has started to blackening in 7 days backs after coating, has shown the hair follicle of now experimental mice
Growth period is initially entered, and begins with melanin deposition；And the mouse of the negative control group and positive controls with the time does not all have
There is generation significant change.The 10th day after to coating, the back of positive controls mouse starts blackening, but does not grow body also by hair
Table；And experimental mice now has had visible undercoat to grow；Meanwhile, negative control group majority mouse still without significant change,
There is individual mice to start blackening due to individual difference back, nonetheless, its extent of growth is still weaker than experimental group.After coating
14 days, the quilt hair of experimental mice was substantially long complete；The quilt hair of positive controls mouse is also incomplete still in growth；And
Negative control group majority mouse does not all start to hair growth.It can be seen that, the hair regeneration speed of experimental mice is significantly faster than that the moon
Property control group and positive controls, and start the time of hair growth also substantially earlier than negative control group and positive controls,
Test result indicate that formula (I) compound has obvious facilitation to hair growth.Because brood same sex is small on the same day
Mouse quantity is insufficient, and the above-mentioned identical zoopery of three repetitions of the present inventor, experimental result is unanimously.
Embodiment 2
Choose the brood female C57BL/6 mouse being born on the same day and (specifically take 55 days, P55 after being born in hair resting stage
The mouse of age in days) it is experimental subjects, doing back shaving with electric shaver is processed.Then it is divided into three groups, every group of 3 mouse.It is cloudy
Property control group：It is daily to smear blank basis cream 0.1g/；Positive controls：It is daily to smear the μ l/ of minoxidil in minoxidil tincture 100 only；It is real
Test group：It is daily to smear test medicine 0.1g/ only.Formula, the formula of the test medicine of blank basis cream are with implementation
Example 1.
After coating 14 days, every group of quilt hair upgrowth situation of mouse is as shown in Fig. 2 wherein, the quilt hair of experimental mice is complete
Minister is complete；The quilt hair of positive controls mouse is also incomplete still in growth；And the quilt hair of negative control group mouse does not have also
Start growth.It can be seen that, the trichogenous effect of formula (I) compound of the present invention is significantly stronger than 5% commercially available minoxidil group.
Mouse put to death when coating 14 days take skin of back and do skin longitudinal section, by preparing paraffin section, through haematine-
Each group skin follicle form is observed after eosin stains, and with (40 times) photos of shooting hair growth state of microscope, such as Fig. 3 institutes
Show.
Paraffin section manufacturing process is as follows：Clip center back fresh skin tissue is affixed on filter paper and flattens, and is soaked in 4%
In paraformaldehyde overnight, then flowing water rinses the unnecessary formaldehyde of a few hours removing；Then dewater treatment is done to tissue block, soaks successively
In 50% ethanol 2h, 75% ethanol 2h, 85% ethanol 2h, 95% ethanol 1.5h, 100% ethanol 1h；Transparent processing, successively by group
Knit block and be soaked in ethanol-xylenes (1: 1) 30min, dimethylbenzene I 20min, dimethylbenzene II 20min；Waxdip, successively will tissue
Block is soaked in wax I 30min, wax II 2h, wax III overnight；Finally embed, the back axis marked before is cut, and is cut
It is fixed in embedded box downwards, then coated with thawing paraffin；Taken out after to be solidified on embedding machine with 0.5 μ m thick cut into slices, 42
Piece is opened up in DEG C water, filter paper suck dry moisture after piece is dragged for clean slide, tissue is close to glass in piece 2h is baked on 62 DEG C of warm tables
Piece.
Section statining process is as follows：Tissue is dewaxed first, dimethylbenzene I 10min, dimethylbenzene II are soaked in successively
10min, dimethylbenzene-ethanol (1: 1) 5min；Rehydration, is soaked in 100% ethanol, 95% ethanol, 85% ethanol, 75% second successively
Each 3min of alcohol；Nuclear targeting, haematine dye liquor immersion 5min, then washing removes removal floating color, hydrochloric acid-alcohol color separation 10s, washing
Anti- indigo plant 30min；It is dehydrated again, cytoplasm dyeing is carried out after sequentially passing through 85% ethanol, each 3min of 95% ethanol, is contaminated with Yihong wink,
Then loose colour, 100% ethanol 3min, ethanol-xylenes (1: 1) 5min, dimethylbenzene I 5min, dimethylbenzene are washed away with 95% ethanol
II 5min；It is last that a drop resinene is added dropwise in slide center, carefully put cover glass mounting.
Visible according to Fig. 3 observations hair follicle form, the mouse back hair follicle of negative control group (smearing blank basis cream) is also
In resting stage, hair follicle is short and small, only hair follicle permanent structure, and hair mastoid process is located at hair follicle lower section and is exposed to skin corium；Positive control
The mouse back hair follicle of group (smearing minoxidil in minoxidil tincture) and experimental group (smearing formula (I) compound) all in growth period, stretch by hair follicle
Long, hair follicle parcel hair mastoid process, skin corium is thickened；The hair follicles outgrowth morphosis and skin molds of experimental group all show normally,
Hair follicle quantity showed increased of the hair follicle quantity of experimental group than positive controls (minoxidil in minoxidil tincture).
Experimental group continues coating 14 days, and mouse back skin, without phenomenons such as peeling, folds, is such as schemed without any allergic symptom
1st, shown in Fig. 2, each side such as skin color, texture with negative or positive controls mouse no significant difference, observe visible, it is small
The physiological situation of mouse life each side is normal.(0.01%~1% mass concentration) is to skin in the concentration range that the medicine is recommended
Skin is nonirritant, non-toxic, ametaboly reaction, using safety, has no toxic side effect.It can be seen that formula (I) compound is fine as effect
Rush hair growth medicine, have very big application value.
Embodiment 3
The brood 50 days mouse of age in days of the female mice being born on the same day of C57BL/6 strains are chosen in this experiment, use electric razor
Knife does back shaving treatment.Then it is divided into three groups, every group of 3 mouse.(1) negative control group：Daily every mouse back is smeared
The basic μ l of aqua 100 of blank.(2) positive controls：Daily every mouse back smears commercially available minoxidil in minoxidil tincture (Man Di, rice
Your content 5% of promise ground) 100 μ l；(3) experimental group：Daily every mouse back smears experiment aqua 100 μ l.Timing is carried on the back to mouse
Portion's hair growth situation is recorded and shot.Other experimental procedures and process etc. are with reference to embodiment 1 and embodiment 2.
Wherein, the formula of blank basis aqua is every 100 milliliters and contains：50 milliliters of ethanol, 20 milliliters of 1,2-PD,
5 milliliters of dimethyl sulfoxide (DMSO), 25 milliliters of water.
Wherein, the experiment aqua refers to that formula (I) compound and blank basis aqua are prepared into the preparation to be formed, and it contains formula
(I) amount of compound is 0.06%.The formula of experiment aqua is every 100 milliliters and contains：50 milliliters of ethanol, the milli of 1,2-PD 20
Rise, 5 milliliters of dimethyl sulfoxide (DMSO), formula (I) compound nitrogen-(chloro- 2, the 5- Dimethoxyphenyls of 4-) -5- isopropyl -2- methoxybenzenes
0.06 gram of sulfonamide, 25 milliliters of water.Wherein, formula (I) compound is first with adding aqua after the dissolving of 5 milliliters of dimethyl sulfoxide (DMSO).
Test result indicate that, the Hair growth rate of experimental mice is significantly faster than that negative control group and positive controls,
Key is that formula (I) compound starts the time of mouse telogen growth also substantially earlier than negative control group and positive control
Group, every group of mouse setation situation with coating process time situation of change, as shown in Figure 1 and Figure 2, experiment effect and embodiment 1 and
2 is identical.As shown in figure 3, experimental mice back hair follicle is transferred to growth period, hair follicle elongation, hair follicle parcel hair mastoid process, corium
Layer is thickened, hair follicle quantity showed increased.Continue coating 14 days, experimental mice skin of back without any allergic symptom, without peeling,
The phenomenons such as fold, show to have no toxic side effect.It can be seen that formula (I) compound is obviously promoted effect to hair growth tool.
Claims (8)
1. the nitrogen shown in formula (I)-(the chloro- 2,5- Dimethoxyphenyls of 4-) -5- isopropyl -2- methoxybenzenesulphoismides are preparing rush
The application entered in the composition of hair growth,
2. application as claimed in claim 1, it is characterised in that the composition is with nitrogen-(chloro- 2,5- dimethoxy benzenes of 4-
Base) -5- isopropyl -2- methoxybenzenesulphoismides be active component.
3. application as claimed in claim 1, it is characterised in that the composition includes pharmaceutical composition or cosmetics.
4. application as claimed in claim 1, it is characterised in that the composition also contains pharmaceutically or cosmetics are acceptable
Carrier.
5. the nitrogen shown in formula (I)-(the chloro- 2,5- Dimethoxyphenyls of 4-) -5- isopropyl -2- methoxybenzenesulphoismides are preparing rush
Application in the hair accelerator for enter hair follicle increasing number, promoting hair follicle to be converted from from resting stage to growth period.
6. it is a kind of to utilize nitrogen as claimed in claim 1-(the chloro- 2,5- Dimethoxyphenyls of 4-)-5- isopropyl-2- methoxybenzenes
Application of the sulfonamide in trichogenous hair accelerator is prepared.
7. application as claimed in claim 6, it is characterised in that the application turns to promote hair follicle from resting stage to growth period
Change, promote the increase of hair follicle quantity.
8. a kind of beauty method of non-treatment purpose, it is characterised in that methods described includes giving object using shown in formula (I)
Compound nitrogen-(the chloro- 2,5- Dimethoxyphenyls of 4-) -5- isopropyl -2- methoxybenzenesulphoismides are promoting the hair of the object
Grow.
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| CN201410545572.8A CN104306168B (en) | 2014-10-15 | 2014-10-15 | Application of N-(4-chloro-2,5-dimethoxyphenyl)-5-isopropyl-2-methoxybenzenesulfonamide in promotion of hair growth |
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| CN201410545572.8A CN104306168B (en) | 2014-10-15 | 2014-10-15 | Application of N-(4-chloro-2,5-dimethoxyphenyl)-5-isopropyl-2-methoxybenzenesulfonamide in promotion of hair growth |
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| CN1389203A (en) * | 2001-05-31 | 2003-01-08 | 辉瑞产品公司 | Method for treating hair-dropping using thyromimetic compound |
| CN1703259A (en) * | 2002-09-27 | 2005-11-30 | 莱雅公司 | Heterocyclic compound for stimulating or inducing hair or eyelash growth and/or for slowing down hair loss, composition containing same, and uses thereof |
| CN101453985A (en) * | 2006-03-28 | 2009-06-10 | 诺华丝国际股份有限公司 | Compositions for promoting hair growth |
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| KR20120006898A (en) * | 2010-07-13 | 2012-01-19 | 이지훈 | Composition for preventing loss of hair and stimulating hair growh |
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| CN1389203A (en) * | 2001-05-31 | 2003-01-08 | 辉瑞产品公司 | Method for treating hair-dropping using thyromimetic compound |
| CN1703259A (en) * | 2002-09-27 | 2005-11-30 | 莱雅公司 | Heterocyclic compound for stimulating or inducing hair or eyelash growth and/or for slowing down hair loss, composition containing same, and uses thereof |
| CN101453985A (en) * | 2006-03-28 | 2009-06-10 | 诺华丝国际股份有限公司 | Compositions for promoting hair growth |
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