CN104274326B - Be gas-cooled dripping pill production line - Google Patents
Be gas-cooled dripping pill production line Download PDFInfo
- Publication number
- CN104274326B CN104274326B CN201410331055.0A CN201410331055A CN104274326B CN 104274326 B CN104274326 B CN 104274326B CN 201410331055 A CN201410331055 A CN 201410331055A CN 104274326 B CN104274326 B CN 104274326B
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- Prior art keywords
- dripping
- dripping pill
- cooling
- water dropper
- cooling pipe
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- 239000006187 pill Substances 0.000 title claims abstract description 135
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- 239000009524 danshen dripping Substances 0.000 description 7
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- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 6
- WTPPRJKFRFIQKT-UHFFFAOYSA-N 1,6-dimethyl-8,9-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione;1-methyl-6-methylidene-8,9-dihydro-7h-naphtho[1,2-g][1]benzofuran-10,11-dione Chemical compound O=C1C(=O)C2=C3CCCC(=C)C3=CC=C2C2=C1C(C)=CO2.O=C1C(=O)C2=C3CCC=C(C)C3=CC=C2C2=C1C(C)=CO2 WTPPRJKFRFIQKT-UHFFFAOYSA-N 0.000 description 6
- 229940116229 borneol Drugs 0.000 description 6
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- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 6
- 239000008188 pellet Substances 0.000 description 6
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- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 2
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- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 description 2
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Classifications
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- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/005—Coating of tablets or the like
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- B08B9/027—Cleaning the internal surfaces; Removal of blockages
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- B08B9/0433—Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes moved by externally powered mechanical linkage, e.g. pushed or drawn through the pipes provided exclusively with fluid jets as cleaning tools
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Abstract
A kind of air cooling dripping pill production line, including dripping pill system, the air cooling circulatory system and control system, dripping pill system includes material tank and coupled water dropper, and vibration device is equipped between material tank and water dropper, and vibration device drives water dropper to vibrate up and down, the nibbling shear shear force of generation, the medical fluid flowed out in water dropper is cut into drop, forms dripping pill after falling into air cooling circulatory system cooling, water dropper mainly includes drip tray, drip tray is equipped with multiple drip hole, and the periphery of drip hole offers spill annular groove；The internal diameter of spill annular groove=+ 0.4 millimeter of drip hole internal diameter, outer diameter >=1.5 millimeter, groove depth are 0.5-5 millimeters.The present invention offers spill annular groove by the periphery of drip hole, prevents in thick liquid high speed ejection, there is remaining medical fluid accumulation around spray orifice, eventually leads to spray orifice blocking or influences dripping；Dripping is cut in conjunction with high frequency, on-line real-time measuremen simultaneously controls to adjust dripping pill quality, improves yield.
Description
Technical field
The present invention relates to a kind of air cooling dripping pill production lines, belong to pill dripping machine manufacturing technology field.
Background technique
Dripping pill is one of Chinese materia medica preparation conventional dosage forms, it is with short production cycle with its, work rapidly, medicine stability it is high and
The plurality of advantages of storage easy to carry and generally approved.
Existing dripping pill production method is substantially nature dripping and combines liquid cooling, or improved by natural dropping preparation method and
The pressurization dropping preparation method and combination liquid come is cooling, and the defect of existing equipment is：1, it based on the characteristic of liquid cooling medium, uses
The dripping pill of this kind of type of cooling dripping, ball weight range will receive certain limitation, usually between 20-30mg, pellet or big ball
It all can not dripping.2, it is simultaneously, guarantee dripping effect, a large amount of matrix need to be added in raw material medical fluid, cause unit drugloading rate small,
Dosage increases accordingly.3, in addition, needing to carry out the solid-liquor separation of dripping pill and coolant liquid, the two in such a way that liquid is cooling
Be completely separated operate it is relatively difficult, therefore, coolant liquid inevitably can on dripping pill exist residual, cause dripping pill to pollute.4,
When needing to adjust yield, traditional dripping equipment is generally only capable of being adjusted by changing water dropper and pressure, dripping frequency compared with
Low, along with biggish paraffin heat exchange surface area is needed, cycle efficieny is low, and energy consumption is high, causes equipment volume big, easily exists clear
Clean dead angle, cross contamination risk are big.
In addition, existing water dropper in thick liquid high speed ejection, has remaining medical fluid accumulation around drip nozzle, eventually lead to
Drip nozzle blocks and influences dripping.It is unstable that the vibration device being arranged in drip tray is possible to the frequency of occurrences in use, leads
It causes pelletization size inhomogenous, directly affects the final product quality of dripping pill.
How existing dripping equipment is improved, including during dripping stability, effectively increase dripping pill forming
Quality and improve speed of production, improve drugloading rate, and expand dripping pill can dripping size range, while reducing energy consumption and coolant liquid and using
Amount, prevents dripping pill from polluting, is the improved development trend of current drilling pill device and research direction.
Summary of the invention
Technical problem to be solved by the present invention lies in view of the deficiencies of the prior art, provide a kind of air cooling dripping pill production
Vibration dripping, cooling be coated with fluidized drying of air are combined as a whole for the first time, and are applied to dropping pill formulation and dripping pill capsule by line
Preparation, meet dripping pill preparation in high speed dripping, prepare pellet ability and improve drugloading rate requirement, significantly improve dripping pill
Supplementary product consumption and taking dose is greatly lowered in drugloading rate；Operational sequence simplifies, entirely without organic solvent residual；Satisfaction includes
Different process requirement including sustained release coating, film coating and sugar coating.It is really achieved low energy consumption, high speed, efficient, high load medicine
Amount, having widely can dripping range；Spill annular groove is further offered by the periphery of drip hole, is prevented in thick liquid height
When speed sprays, there is remaining medical fluid accumulation around spray orifice, eventually leads to spray orifice blocking or influence dripping.
It is of the invention that the technical problem to be solved is that be achieved through the following technical solutions：
A kind of air cooling dripping pill production line, including dripping pill system, the air cooling circulatory system and control system, dripping pill system include changing
Batch can and coupled water dropper, are equipped with vibration device between the material tank and water dropper, vibration device drives water dropper to shake up and down
Dynamic, the medical fluid flowed out in water dropper is cut into drop by the nibbling shear shear force of generation, forms drop after falling into air cooling circulatory system cooling
Ball, the water dropper mainly include drip tray, and drip tray is equipped with multiple drip hole, and the periphery of drip hole offers spill annular groove.
As needed, the internal diameter of the spill annular groove=+ 0.4 millimeter of drip hole internal diameter, outer diameter >=1.5 millimeter, groove depth are
0.5-5 millimeters.
For the ease of monitoring on-line and controlling, the water dropper is equipped with on-Line Monitor Device, which includes pulse signal
The tranmitting frequency of trigger mechanism, the pulse signal trigger mechanism is identical as the vibration frequency of the vibration device, control system
According to the monitoring result of on-Line Monitor Device, dripping parameter is controlled to adjust.
For the ease of observation, the side below the water dropper is arranged in the on-Line Monitor Device；The pulse signal hair
Penetrating mechanism is stroboscopic lamp, and the stroboscopic lamp is identical with the vibration frequency of vibration device；In order to keep observation result more accurate and have
Effect retains monitoring record, and the on-Line Monitor Device further includes the camera being correspondingly arranged with stroboscopic lamp, camera and stroboscopic lamp
It is in 15 ° of -145 ° of angles in same level, and with stroboscopic light irradiation route.
Specifically, the dripping parameter mainly includes：
The vibration frequency of the stroboscopic lamp and vibration device：50-300HZ, preferably 90-200Hz, optimal 130-140HZ；
Dripping speed：10-40Kg/hr, preferably 12-30Kg/hr, optimal 15-25Kg/hr；
Dripping acceleration：1-20G, preferably 3-10G, optimal 3.5-4.5G；
Dripping pressure：0.5-4.0Bar, preferably 1.0-3.0Bar, optimal 1.8Bar；
Water dropper temperature：70-200 DEG C, preferably 70-100 DEG C, optimal 75-85 DEG C.
In order to guarantee that dripping temperature is constant, be equipped with incubation cavity outside the water dropper, the outer layer of the incubation cavity be equipped with every
Hot material, internal layer are equipped with steam heater or infrared heating device, and the lower section of incubation cavity is equipped with opening, the position of opening and drop
The outlet port of head is correspondingly arranged, and the size of opening and the width of water dropper are correspondingly arranged.
The air cooling circulatory system includes：Cooling pipe, and connect with the cooling pipe and freeze to cooling pipe
Refrigerating plant, the cooling pipe is externally provided with interlayer, and the interlayer lower part is connected to by communication port with cooling pipe inside；
The refrigerating plant includes：Cold wind refrigerating plant and cold-trap refrigerating plant, wherein：
The cold wind refrigerating plant includes：Freezer, the air outlet of the freezer are connected with the cold air inlet of cooling pipe
It is logical, so that cold wind is recycled rising in cooling pipe inner cavity；
The cold-trap refrigerating plant includes：Coolant storage tank equipped with refrigerant, and to the refrigerant system in coolant storage tank
Cold refrigeration machine and heat exchanger, the refrigerant exit of the coolant storage tank is connected with the refrigerant inlet that the interlayer top is arranged, cold
Matchmaker is inputted in interlayer by refrigerant inlet, is transmitted to interlayer lower part from interlayer top and is transferred in cooling pipe inner cavity；It is described
Refrigerant recycles rising simultaneously in the inner cavity of cooling pipe with cold wind, and passes through cooling pipe top discharge or recycling；
In order to reach preferable cooling effect, the cooling pipe is straight barrel type or spiral type pipe, and the length is 5-10
Rice；Preferably 6 meters.
In order to keep cleaning to prevent frosting, the cooling pipe is equipped with on-line cleaning equipment, including：Cleaning unit, control
Unit, elevation driving unit and lifting unit processed, described control unit drive lifting unit to drive clearly by elevation driving unit
The cooling pipe top outer of cooling device is arranged in clean unit lifting, the lifting unit；
The lifting unit includes：Cleaning unit support frame, cleaning pipeline, cleaning pipeline support frame, cleaning pipeline storage
Disk and sealing adapter tube；The cleaning pipeline support frame extends to cleaning pipeline inside cooling pipe；The cleaning unit bracket
Including multiple support wheels, each described support wheel is supported with cooling pipe inner sidewall, and the cleaning unit and the cleaning are managed
Road extends to the connection of one end inside cooling pipe, and so that cleaning unit is prolonged cooling pipe center liter by cleaning unit support frame
Drop；One end of the sealing adapter tube is connect with the other end of cleaning pipeline, for importing cleaning solution in the cleaning pipeline；
The lifting unit further includes：On-Line Monitor Device, the on-Line Monitor Device include：Image acquisition units and meter
Unit is calculated, described image acquisition unit is set on the cleaning unit, for acquiring the realtime graphic in cooling pipe, will be schemed
As signal is sent to computing unit, the computing unit according to the picture signal be converted to numerical value and and threshold value comparison, if the number
Value is greater than threshold value, then sends driving signal to control unit and the cleaning unit is driven to be cleaned.
The air cooling dripping pill production line further includes fluidized drying coated systems, which mainly includes fluidized bed, the cooling
The end of pipeline is connected by vacuum pipe with the entrance of fluidized bed, will be inputted by the dripping pill vegetable pill vacuum feeding of air cooling sizing
Fluidized drying is coated in fluidized bed；
The fluidized bed includes furnace body, is equipped with material feed inlet below furnace body, is equipped with air-flow in the lower section of the feed inlet
The bottom of distribution grid, the airflow-distribution board is connected with the wind pipe of room temperature low humidity supply air system, and the room temperature low humidity is sent
Room temperature low humidity gas is sent into fluid bed furnace body by wind system by wind pipe, and is carried out to the material for being built in furnace interior
Fluidized drying processing；
The room temperature low humidity supply air system includes shell and setting in the intracorporal low humidity unit of shell, and shell is equipped with blast pipe
Road and wind pipe, air after the processing of low humidity unit through wind pipe input the furnace body after entering shell from intake stack；
The room temperature low humidity supply air system further includes the return air duct for air flow recovery, both ends respectively with the furnace body
It is connected with shell.
The drying temperature of the fluidized bed is -20 DEG C -100 DEG C, and drying time is 1-4 hours；The fluidized bed is preferably adopted
With gradient increased temperature seasoning, -20-30 DEG C of formation fluidize state, and 15-35 DEG C is 10-120 minutes dry, and 35-55 DEG C dry 10-60 points
Clock, 55-100 DEG C 0-60 minutes dry；Most preferably 0-20 DEG C formation fluidizes state, 25 DEG C drying 60 minutes, 45 DEG C drying 30 minutes,
55 DEG C 0-30 minutes dry.
In conclusion the present invention will vibrate, dripping, air are cooling to be combined as a whole with fluidized drying coating, and is applied to drop
Pill and dripping pill capsule preparations meet in dripping pill preparation to high speed dripping, prepare pellet ability and improve drugloading rate
It is required that significantly improving dripping pill drugloading rate, supplementary product consumption and taking dose is greatly lowered；Operational sequence simplifies, entirely without organic
Dissolvent residual；Meet the different process requirement including sustained release coating, film coating and sugar coating.Be really achieved low energy consumption,
At a high speed, efficiently, high drug load, having widely can dripping range；Spill annular groove is further offered by the periphery of drip hole,
It prevents in thick liquid high speed ejection, there is remaining medical fluid accumulation around spray orifice, eventually lead to spray orifice blocking or influence dripping.
In the following with reference to the drawings and specific embodiments, technical solution of the present invention is described in detail.
Detailed description of the invention
Fig. 1 is overall structure of the present invention；
Fig. 2 is drip tray cross-sectional view of the present invention；
Fig. 3 is the A partial structurtes enlarged drawing of Fig. 2；
Fig. 4 is refrigerating device structure schematic diagram of the present invention；
Fig. 5 is the overall structure diagram of on-line cleaning equipment of the present invention；
Fig. 6 is the control block diagram of on-line cleaning equipment of the present invention；
Fig. 7 is the overall structure diagram of fluidized bed of the present invention.
Specific embodiment
Fig. 1 is overall structure of the present invention.As shown in Figure 1, the present invention provides a kind of air cooling dripping pill production line, including
Dripping pill system, the air cooling circulatory system and control system, dripping pill system include material tank 100 and coupled water dropper 200, described
Vibration device 300 is equipped between material tank 100 and water dropper 200, vibration device drives water dropper to vibrate up and down, the oscillatory shear of generation
The medical fluid flowed out in water dropper is cut into drop by power, forms dripping pill after falling into air cooling circulatory system cooling, the water dropper is equipped with
Line monitoring device, the device include pulse signal trigger mechanism, the tranmitting frequency and the vibration of the pulse signal trigger mechanism
The vibration frequency of dynamic device is identical, and control system controls to adjust dripping parameter according to the monitoring result of on-Line Monitor Device.It is described
Dripping parameter includes：The vibration frequency of the stroboscopic lamp and vibration device：50-300HZ, preferably 90-200Hz, optimal 130-
140HZ；Dripping speed：10-40Kg/hr, preferably 12-30Kg/hr, optimal 15-25Kg/hr；Dripping acceleration：1-20G, preferably
3-10G, optimal 3.5-4.5G；Dripping pressure：0.5-4.0Bar, preferably 1.0-3.0Bar, optimal 1.8Bar；Water dropper temperature：70-
200 DEG C, preferably 70-100 DEG C, optimal 75-85 DEG C.
As needed, the side below the water dropper is arranged in the on-Line Monitor Device；The pulse signal transmitter
Structure is stroboscopic lamp 201, and the stroboscopic lamp is identical with the vibration frequency of vibration device.It is described online for the ease of observing and recording
Monitoring device can also include the camera (not shown) being correspondingly arranged with stroboscopic lamp, and camera is in same with stroboscopic lamp
It on horizontal plane, and is in 15 ° of -145 ° of angles with stroboscopic light irradiation route.
That is, vibration dripping of the present invention, will mainly melt medical fluid pressurized delivered to water dropper, and utilize magnetic
Power/electric and pneumatic vibration principle, vibrates water dropper above and below with setpoint frequency, waveform and amplitude, acts on oscillatory shear power
Fluid column forms it into drop, it is generally the case that vibration frequency is between 50-300Hz.It can according to need using magnetic force or electricity
The mode of dynamic vibration, has vibration frequency height, and the small feature of amplitude is suitble to the high speed dripping of low-viscosity material.Under normal circumstances,
The mode of pneumatic vibration, vibration frequency, amplitude are big.When material viscosity is more than 800cp (centipoise), electronic mode then can not be by object
Material effectively cutting.Emitter clogging is caused, when influencing dripping pill preparation, pneumatic vibration mode can be used.
In order to eliminate in feed liquid transmission process, dripping process is generated due to the pressure pulse that feed liquid springs up generation shadow
It rings, guarantees that feeding is steady, be additionally provided with surge tank 500 between the material tank 100 and water dropper 200.Surge tank 500 is equipped with compression
Air intlet is connected by pressure pipeline with air pump, and pressure pipeline is equipped with pressure-regulating valve, and medical fluid in surge tank is made to keep permanent
Pressure supply.The surge tank is equipped with liquidometer, for controlling charging rate；Surge tank is additionally provided with insulating layer, using water-bath, oil bath
And electric tracing thermal insulation；And there is temperature sensor to monitor feed liquid temperature；The agitating paddle of adjustable mixing speed is equipped in surge tank.Tank
Inner sensor can be configured to contact or contactless.Tank body material can be used 304,316L or other and can directly contact with product
Heat proof material.
Fig. 2 is drip tray cross-sectional view of the present invention；Fig. 3 is the A partial structurtes enlarged drawing of Fig. 2.Such as Fig. 2 and as shown in connection with fig. 3, this
The water dropper 200 of invention mainly includes drip tray 210, and drip tray 210 is equipped with multiple drip hole 220, circle of the drip hole 220 in drip tray 210
It is equidistantly spaced in circumferential direction.As shown in figure 4, drip hole 220 is made of cylindrical cavity 221, conical cavity 222 and straight tube chamber 223,
Drop drips from the end of straight tube chamber 223.In the drip tray 210 towards on the side of cooling tank 600, exported in straight tube chamber 223
Periphery offer spill annular groove 230.Since the aperture D0 that straight tube chamber 223 exports is usually 0.1-5mm, the spill annular groove
230 internal diameter D1=D0+0.4mm, 2 >=1.5 millimeters of outer diameter D, groove depth h is 0.5-5mm.In addition, the diameter d of cylindrical cavity 221 is
0.5-1mm, the taper of conical cavity 222 are 20 ° -170 °, and the overall thickness A of drip tray 210 is 6mm, the height H=of straight tube chamber 223
(0.5-6)D0.By opening up spill annular groove 230 in the periphery of drip hole 220, it can prevent in thick liquid high speed ejection, drip
There is remaining medical fluid accumulation around hole 220, eventually lead to the blocking of drip hole 220 or influences dripping.
Water dropper 200 can choose direct exposure, also can choose setting in order to keep fluid temperature constant, outside water dropper and protects
Warm chamber makes the temperature of water dropper be maintained at 70-200 DEG C or so.The outer layer of incubation cavity is equipped with heat-barrier material, and internal layer is heated equipped with steam
Device or infrared heating device change to influence dripping effect to avoid medical fluid viscosity caused by temperature change.Incubation cavity
Lower section be equipped with opening, the position of opening and the outlet port of water dropper be correspondingly arranged, and the size of opening and the width of water dropper are corresponding
Setting.It is may be designed as inside incubation cavity with certain arc angle, it is less than square cavities dead angle, it is easier to clean；It protects
Warm chamber lower ending opening, to guarantee the normal whereabouts of dripping pill.
Simultaneously in the side-lower of water dropper 200, it is configured with stroboscopic lamp 201, with the dripping situation for monitoring dripping pill.By same
Cadence dodges principle, and operator can only need visually, can observe in real time under high speed falling state, certainly, in order to observe and record
It is convenient, real-time monitoring can also be carried out to image by camera.By under a certain vibration frequency, such as：The drop of 50Hz or more
When speed processed, to the face shaping of dripping pill, the real time monitoring and accurate adjusting of dripping state are realized.That is, in dripping mistake
While journey, using vibrational waveform as the monitoring index of PAT, the particle diameter distribution situation of dripping pill can be measured, and stroboscopic can be passed through
Device monitors the fluidized state of dripping pill in real time.By adjusting vibration parameters, drugloading rate can be improved to 50% or more, auxiliary material
It is greatly reduced.By adjusting vibration parameters, dripping pill diameter can be adjusted between 0.2mm-3mm, and can produce and can preferably expire
The Miniature Chinese medicine dripping pellet of the sufficient filling requirement of capsule.The stroboscopic that the present invention uses checks in real time and monitoring technology on-line, so that
Dripping pill product yield is increased to 95% or more by traditional 70%.
As shown in connection with fig. 1, the air cooling circulatory system of the invention includes：Cooling pipe 600, and with the cooling pipe
600 connections and the refrigerating plant to freeze to cooling pipe.The water dropper 200 of dripping pill device is arranged in the cooling pipe 600
Underface, the cooling pipe 600 can be straight barrel type or spiral type pipe, as needed, the length of the cooling pipe 600
For 5m-10m, preferred length is 6m.The cooling pipe 600 is externally provided with interlayer 610, and 610 lower part of interlayer passes through connection
Mouthfuls 601 be connected to inside cooling pipe 600.
Fig. 4 is refrigerating device structure schematic diagram of the present invention.As shown in figure 4, the cold wind refrigerating plant includes：Cold wind refrigeration
Device 4, the cold wind refrigerating plant include freezer 41, and the air outlet of the freezer 41 and the cold wind of cooling pipe 600 are entered the wind
Mouth is connected, and cold wind is made to recycle rising, the cold air inlet of the cooling pipe 600 and Suiping in 600 inner cavity of cooling pipe
Face angle a is 0 ° -90 °.It is quickly cooled down to further realize, the refrigerating plant further includes cold-trap refrigerating plant 5, described
Cold-trap refrigerating plant 5 includes：Coolant storage tank 51 equipped with refrigerant, and to the refrigeration that the refrigerant in coolant storage tank 51 freezes
The refrigerant exit of machine 52 and heat exchanger 53, the coolant storage tank 51 is entered by pump 54 and the refrigerant of 610 top of interlayer setting
Mouth is connected, and refrigerant is inputted in interlayer 610 by refrigerant inlet, is transmitted to 610 lower part of interlayer from 610 top of interlayer and is transferred to cold
But in 600 inner cavity of pipeline；The refrigerant recycles rising simultaneously in the inner cavity of cooling pipe 600 with cold wind, and with pass through cooling
The discharge of gas concentration unit 6 connected at the top of pipeline 600 or recycling refrigerant and cold wind.Refrigerant generallys use：Nitrogen, argon gas or two
Carbonoxide etc..
Fig. 5 is the overall structure diagram of on-line cleaning equipment of the present invention.As shown in figure 5, in order to keep cleaning, the drop
Ball air cooling production line further include：On-line cleaning equipment, the equipment include：Cleaning unit 10, cleaning monitoring control unit 11, lifting
Driving unit 12 and lifting unit 13, the cleaning unit 10 are spray head or the spray head with cleaning cloth.The cleaning prison
It surveys control unit and drives lifting unit that cleaning unit 10 is driven to go up and down in cooling pipe 600 by elevation driving unit, it is described
The outside at 600 top of cooling pipe is arranged in lifting unit.Wherein, the lifting unit includes：Cleaning unit support frame 131,
Monitoring device is taken over and is cleaned online in cleaning pipeline 132, cleaning pipeline support frame 133, cleaning pipeline storage tray 134, sealing,
Such as：Camera.The cleaning pipeline support frame 133 extends to cleaning pipeline 132 inside cooling pipe 600.The cleaning is single
First bracket 131 includes multiple support wheels 1311, each described support wheel 1311 is supported with 600 inner sidewall of cooling pipe, described
Cleaning unit 10 is connect with one end that the cleaning pipeline 132 extends to inside cooling pipe 600, and is supported by cleaning unit
Frame 131 makes cleaning unit 10 prolong the lifting of 600 center of cooling pipe.One end of the sealing adapter tube 135 is another with cleaning pipeline 132
One end connection, for importing cleaning solution in the cleaning pipeline 132.
More specifically, as shown in figure 5, the elevation driving unit of on-line cleaning equipment includes：Motor 121, driving wheel 122,
Sprocket wheel 123, belt 124 and tensioning wheel 125, the motor 121 are connect with driving wheel 122, and the driving wheel 122 passes through belt
124 connect with sprocket wheel 123, and the sprocket wheel 123 is connect with the cleaning pipeline storage tray 134, and the cleaning monitors control unit
11 connect with motor 121；Tensioning wheel 125 passes through belt 124 and sprocket wheel 123 between sprocket wheel 123 and driving wheel 122
It is connected with driving wheel 122.Except of course that outside specific structure documented by elevation driving unit of the invention, those skilled in the art
Can also driving lifting work be completed using the elevation driving unit of other structures according to actual needs.
Fig. 6 is the control block diagram of on-line cleaning equipment of the present invention.As shown in fig. 6, the online cleaning monitoring device 136 is wrapped
It includes：Image acquisition units 1361 and computing unit 1362, described image acquisition unit 1361 are set on the cleaning unit 10,
Described image acquisition unit 1361 is that camera sends picture signal to for acquiring the realtime graphic in cooling pipe 600
Computing unit 1362, the computing unit 1362 according to the picture signal be converted to numerical value and and threshold value comparison, if the numerical value is big
In threshold value, then driving signal is sent to cleaning monitoring control unit 11 and the cleaning unit 10 is driven to be cleaned.
In summary and Fig. 5 and Fig. 6 is combined, the course of work of on-line cleaning equipment of the present invention is such：Firstly, image
Acquisition unit 1361 acquires the image in cooling pipe 600, and the computing unit 1362 that acquired image is sent in real time；Its
Secondary, the computing unit 1362 is converted to numerical value according to acquired image in S1, and be stored in computing unit 1362
Threshold value be compared, if the numerical value be greater than threshold value if enter in cleaning procedure, otherwise image acquisition units 1361 continue
Implement acquisition image；Again, computing unit 1362 calculates the quantity of cleaning solution required for cleaning cooling pipe 600 and to cleaning
It monitors control unit 11 and sends driving signal；Then, the cleaning monitoring control unit 11 is issued according to computing unit 1362
Signal issues stop signal to dripping system, after stopping dripping pill work, respectively drives elevation driving unit 12 and valve 142, makes
Cleaning unit 10 prolongs 600 central axis of cooling pipe and runs from top to bottom and spray cleaning solution；When cleaning unit 10 is moved to cooling
When 600 lower part of pipeline, cleaning terminates, and cleaning monitoring control unit 11 controls elevation driving unit 12 and valve 142 respectively,
Control cleaning unit 10 stops spraying and executes cleaning repeatedly after returning to 600 top of cooling pipe, until clean up for
Only.
Fig. 7 is the overall structure diagram of fluidized bed of the present invention.Such as Fig. 7 and as shown in connection with fig. 1, the air cooling dripping pill production line
It further include fluidized drying coated systems 700, which mainly includes fluidized bed 710, and the fluidized bed 710 includes furnace body, furnace body
Lower section is equipped with material feed inlet 711, and the end of the cooling pipe 600 passes through the feed inlet 711 of vacuum pipe and fluidized bed 710
It is connected, by the dripping pill vegetable pill by air cooling sizing from fluidized drying is coated in vacuum feeding input fluidized bed from feed inlet 711.?
The lower section of the feed inlet 711 is equipped with airflow-distribution board 712, and airflow-distribution board 712 is equipped with through-hole, room temperature low humidity supply air system
720 are interconnected by pipeline and furnace body, and air inlet position is located at the lower section of airflow-distribution board 712, are blown up.Existed by setting
Through-hole on airflow-distribution board 712 can not only cause air flow through, but also the intracorporal material whereabouts of furnace can be effectively prevented and omit.
Room temperature low humidity supply air system 720 includes shell 721 and is arranged in the intracorporal low humidity unit 722 of shell, and shell is equipped with
Air inlet 723 and wind pipe 724.Air is after the entrance shell of air inlet 723 through wind pipe after the processing of low humidity unit 722
724 input furnace interior from furnace body air inlet 725, and carry out fluidized drying processing to the material for being built in furnace interior.In addition,
Room temperature low humidity supply air system 720 further includes the return air duct 726 for air flow recovery, both ends respectively with the furnace body and shell phase
Even.The low humidity unit 722 is the combination of a variety of processing units, successively includes removing according to airflow direction shown in arrow in Fig. 7
Dirt device, dehumidification device, air supply device, heating device, filter device and effective filter.
When fluidized bed work, 711 vacuum feeding of feed inlet above furnace body is first passed through, then led to by furnace body air inlet 725
Enter the gas crossed through process such as 722 dry heat filtered compresseds of low humidity unit, it is processed after gas humidity≤5g/kg,
Injection pressure is 1-4bar, and temperature is -20-100 DEG C, preferably 20-60 DEG C.Keep goods fluid dry to humidity 4% when progress
Coating, the finished product output after being then coated fluidized drying by device for discharging discharging, exhaust gas are discharged from exhaust duct 727.
As needed, it is generally the case that the drying temperature of the fluidized bed is -20 DEG C -100 DEG C, and drying time is that 1-4 is small
When.In order to keep dripping pill to be in fluidized state, solving the problems, such as dripping pill adhesion while improve production efficiency, the fluidized bed is preferred
Using gradient increased temperature seasoning, -20-30 DEG C of formation fluidize state, and 15-35 DEG C 10-120 minutes dry, 35-55 DEG C of dry 10-60
Minute, 55-100 DEG C is 0-60 minutes dry；Most preferably 0-20 DEG C formation fluidizes state, 25 DEG C drying 60 minutes, 45 DEG C of 30 points of dryings
Clock, 55 DEG C 0-30 minutes dry.In order to detect dripping pill moisture effectively convenient for controlling, it is additionally provided in the fluidized bed for monitoring
The on-line measuring device 800 of pellet water content and particle diameter distribution situation, the online moisture content detection device can be sensed using moisture
The existing detection part of device or probe etc, since for the prior art, details are not described herein.
As the all-in-one machine of dripping cooling and fluidized drying coating, increased fluidized drying solves air cooling equipment
The dripping pill of preparation is during storage, in fact it could happen that adhesion and the problem of at analyzing, also ensure that dripping pill moisture can reach
Stationary value improves the uniformity that equipment carries medicine and coating.Injection hot melt medical fluid carries out load pack and wraps up in, and can further improve dripping pill
Drugloading rate；Equipment injection can also be used to carry out dripping pill coating, to meet different process requirement, such as：Sustained release coating, film packet
Clothing, sugar coating etc..
In conjunction with shown in Fig. 1 and Fig. 4, specifically, the course of work of the invention is such：It is pushed using surge tank 500
The medical fluid melted is transported in the water dropper 200 with incubation cavity by medical fluid, and the water dropper 200 has and 210 bottom of incubation cavity
The outlet of portion's opening same direction, it is ensured that medical fluid can be oozed from 200 bottom of water dropper.Using pressure, make admixing medical solutions from water dropper
200 outlet at bottom outflow.According to the size of required dripping pill, adjusts pressure or pneumatically or electrically vibrates the vibration parameters of water dropper,
The powder column flowed out from water dropper 200 is set to be cut into the medicine drop of required diameter.Wherein vibration acceleration 0-110g (sine) vibrates width
It spends (0-25.4mm).
Simultaneously start gas refrigeration, using low temperature make the medicine oozed drop in cooling pipe 600 cooled and solidified at solid-state
Grain, and be collected in 600 lower end of cooling pipe.The opening of the incubation cavity lower end of the upper port and water dropper 200 of cooling pipe 600
Sealing connection, the lower end of cooling pipe 600 are hatch frame corresponding with dripping pill collecting vessel.
Freezer 41 is entered the cold wind manufactured by cold air inlet in the inner cavity of cooling pipe 600 in circulation
It rises, while refrigerant is input in interlayer 610 by coolant storage tank 51 by refrigerant inlet, the flow direction of refrigerant is in interlayer 610 at this time
From top to bottom, and by the communication port 601 that the interlayer 610 is connected to cooling pipe 600 the interior of cooling pipe 600 is entered
Chamber mixes and recycles rising with the cold wind in 600 inner cavity of cooling pipe, when the mixed gas of refrigerant and cold wind rises to cooling
When pipeline top, by gas concentration unit 6 respectively by cold wind and refrigerant recovering into freezer 41 or coolant storage tank 51, Huo Zhetong
It crosses gas concentration unit 6 mixed gas is emitted into atmosphere, specific discharge process refers to foregoing teachings.
Due to being directly blown at an angle between cooling air and cooling pipe 600, cold wind and refrigerant are in cooling pipe
Laminar flow is formed in 600, so that the medicine continuously oozed drop is obtained the purging of the gas of a small amount of lower temperature, is maintained a certain distance, keep away
Exempt from dripping pill to be adhered in this region, influences subsequent molding.
Then, 600 end of cooling pipe is connected to fluidized drying coated systems 700 by pipeline, adjusts air inlet and air draft
Air quantity, and temperature range is controlled, the piller after drying is discharged by negative pressure of vacuum, and fluidized bed is rejoined after being sieved, and is adjusted
Section air inlet and air draft air quantity are carried out carrying medicine or film coating by technique requirement；After coating equipment can also connect capsule filling machine into
Row perfusion, capsule check-weighing machine are carried out by grain check weighing.Therefore, according to the actual application, integrally-built basis shown in Fig. 1
On, air cooling dripping pill production line provided by the present invention can also configure capsule filling machine and capsule check weighing device.Above-mentioned apparatus is equal
For the prior art, details are not described herein.
Implement example below by way of best, equipment of the invention is further described in detail.The example is only used for
The bright present invention, and there is no limit to the present invention.
Embodiment one prepares compound danshen dripping pills
(1) material step：Salvia miltiorrhiza and Panax notoginseng extract 600g is taken, borneol 5g and Macrogol 6000 (PEG-6000) are auxiliary
Expect 2000g.First PEG-6000 is added in material tank, is heated to 90 DEG C, is melted in advance, adds Salvia miltiorrhiza and Panax notoginseng extract to
5000rpm homogeneous mixes in matter machine, and time 200min, then 10000rpm homogeneous material, time 100min, are obtained by 100 DEG C of temperature
It is mixed into liquid.
(2) dripping step：The vibration frequency for adjusting pneumatic vibration water dropper is 300Hz, and moist closet is kept the temperature using steam jacket,
Temperature controls 200 DEG C, and dripping speed and step (1) material speeds match, dripping pressure are 3Bar, dripping speed 10kg/hr, drop
Acceleration 1G processed.
(3) condensing steps：It is supplied gas from air pump by pipeline into material tank, flows into the aforesaid liquid melted to water dropper
And ooze from water dropper bottom into cooling pipe, cooling pipe is perpendicular to the ground；Start cold air, cooling temperature is made to reach -120
DEG C, the angle of cooling air inlet and horizontal plane is 30 °, and makes cold air in cooling pipe internal circulation flow, is made from the medicine oozed
Drop cooled and solidified in cooling pipe can be connected to Fluidized Bed Partial from the pipeline of cooling pipe lower end and carry out at solid-state dripping pill
Fluidized drying and load pack clothing.
(4) drying steps：Then dripping pill is subjected to fluidized drying and carries pack clothing, to material -20 DEG C -30 DEG C in bed body
After forming preferable fluidised form, 50 DEG C of dryings drying in 2 hours 120 minutes, vegetable ball moisture was controlled 5.0%, obtained intermediate vegetable pill.
(5) coating steps：Coating powder dosage is calculated according to coating inventory and prescription, the concentration of coating solution is 10%, is matched
Coating solution processed stirs 45 minutes.Inlet air temperature is set as 40 DEG C by after qualified dripping pill investment fluidized bed, improves setting inlet air temperature
To 48 DEG C, after temperature of charge reaches 38 DEG C, start to be coated.At 35-45 DEG C, coating is completed for temperature of charge control in coating process
After be cooled to 30 DEG C with bottom discharge, sieve ball, partial size is 2.0mm dripping pill.
Embodiment two prepares Danshen Root dropping ball
(1) material step：Salvia root P.E 600g is taken, water 60g is added, adds Macrogol 6000 auxiliary material 1500g, is put into material
It is heated to 90 DEG C in tank, using low speed homogeneous (3200rpm) mixed material, after the completion of mixing, improves homogeneous speed to 5000rpm
Progress material, the time 6 minutes.Melt it completely and is mixed into liquid.
(2) dripping step：The vibration frequency for adjusting pneumatic vibration water dropper is 50Hz, and moist closet is kept the temperature using infrared heating,
Temperature controls 70 DEG C, and dripping pressure is 4Bar, dripping speed 40kg/hr, dripping acceleration 3G.
(3) condensing steps：It is supplied gas from air pump by pipeline into material tank, makes to have melted uniform aforesaid liquid to water dropper
It flows into and oozes from water dropper bottom into cooling pipe, dripping pressure 0.18MPa starts cold while aforesaid liquid oozes
Gas makes cooling temperature reach -10 DEG C, and makes cold air in cooling pipe internal circulation flow, the folder of cooling air inlet and horizontal plane
Angle is 45 °, and making the medical fluid oozed from water dropper drop, cooled and solidified is at solid-state dripping pill in cooling pipe, and from cooling pipe lower end
Pipeline is connected to Fluidized Bed Partial.
(4) fluidisation：Then dripping pill is subjected to fluidized drying and carries pack clothing, formed in bed body to material preferable
After fluidised form, 25 DEG C of dryings 60 minutes are warming up to, then are warming up to 45 DEG C of dryings 30 minutes, are continuously heating to 55 DEG C of dryings 30 minutes,
Then 30 DEG C are cooled to bottom discharge.Vegetable ball moisture is controlled in 3.0-7.0%, obtains intermediate vegetable pill.
(5) coating steps：Coating powder dosage is calculated according to coating inventory and prescription, the concentration of coating solution is 18%, is matched
Coating solution processed stirs 45 minutes.Inlet air temperature is set as 25 DEG C by after qualified dripping pill investment fluidized bed, improves setting inlet air temperature
To 48 DEG C, after temperature of charge reaches 38 DEG C, start to be coated.At 35-45 DEG C, coating is completed for temperature of charge control in coating process
After be cooled to 30 DEG C with bottom discharge, sieve ball, partial size is 1.0-2.0mm dripping pill.
Embodiment three prepares compound danshen dripping pills
(1) material step：Take Salvia miltiorrhiza and Panax notoginseng extract 600g, borneol 5g and Macrogol 6000 auxiliary material 2000g.First
Polyethylene glycol is added in material tank, is heated to 80 DEG C, is melted in advance, is added Salvia miltiorrhiza and Panax notoginseng extract, put into homogenizer
Middle 2500rpm homogeneous mixing, time 100min, then 6000rpm homogeneous material, time 20min, are uniformly mixed by 100 DEG C of temperature
At liquid.
(2) dripping step：The vibration frequency for adjusting pneumatic vibration water dropper is 90HZ, acceleration 3.5G, dripping speed 12Kg/
Hr, dripping pressure 1.0Bar.Moist closet is kept the temperature using steam jacket, and temperature controls 70 DEG C,
(3) condensing steps：It is supplied gas from air pump by pipeline into material tank, flows into the aforesaid liquid melted to water dropper
And ooze from water dropper bottom into cooling pipe, cooling pipe is perpendicular to the ground；Start cold air, cooling temperature is made to reach -100
DEG C, the angle of cooling air inlet and horizontal plane is 90 °, and makes cold air in cooling pipe internal circulation flow, is made from the medicine oozed
Drop cooled and solidified in cooling pipe can be connected to Fluidized Bed Partial from the pipeline of cooling pipe lower end and carry out at solid-state dripping pill
Fluidized drying and load pack clothing.Specifically, 20 DEG C of formation fluidize state, 25 DEG C drying 60 minutes, 45 DEG C drying 30 minutes, 55 DEG C
It is 30 minutes dry.
Example IV prepares compound danshen dripping pills
(1) material step：By compound Salviae Miltiorrhizae extract and Arabic gum and lactose=1:1 mixture puts into homogenizer
Middle 5000rpm homogeneous mixing, time 200min, then 10000rpm homogeneous material, time 100min, are obtained intermediate by 100 DEG C of temperature
Body feed liquid；
(2) dripping step：Intermediate feed liquid vibrates dripping, vibration frequency 200Hz through water dropper, and dripping pressure is
4.0Bar, 100 DEG C of water dropper temperature, dripping speed and step (1) material speeds match are 15kg/hr；
(3) condensing steps：The medicine oozed drips the dripping pill element for being quickly cooled down in cooling gas and being frozen into that diameter is 4.0mm
Ball, the cooling gas temperature are -300 DEG C.
It can be connected to Fluidized Bed Partial from the pipeline of cooling pipe lower end and carry out fluidized drying and load pack clothing.It is specific next
Say, 0 DEG C of formation fluidizes state, 25 DEG C drying 60 minutes, 45 DEG C drying 30 minutes, 55 DEG C drying 30 minutes.
Embodiment five prepares compound danshen dripping pills
Compound Salviae Miltiorrhizae extract 75g, borneol 7.5g, lactitol 165g are taken, compound Danshen Root droplet ball, preparation method are prepared into
It is as follows：
(1) material step：Compound Salviae Miltiorrhizae extract is put into 2500rpm homogeneous in homogenizer with lactitol to mix, when
Between 100min, then 6000rpm homogeneous material, time 50min, obtain intermediate feed liquid by 80 DEG C of temperature；
(2) dripping step：Intermediate feed liquid vibrates dripping, vibration frequency 130Hz through water dropper, and dripping pressure is
1.8Bar, 140 DEG C of water dropper temperature, dripping speed and step (1) material speeds match are 25kg/hr；
(3) condensing steps：The medicine oozed drips the dripping pill vegetable pill for being quickly cooled down in cooling gas and being frozen into that diameter is 1mm,
The cooling gas temperature is -100 DEG C.
(4) drying steps：It is dry using fluidization drying apparatus, -20 DEG C drying 4 hours, obtain dry dripping pill vegetable pill.
(5) coating steps：The drying vegetable pill is coated in a fluidized bed, and coating material and vegetable pill weight ratio are 1：25,
Coating solution concentration is 10%, and 40 DEG C of temperature are coated up to coated drop pill.
Embodiment six prepares compound danshen dripping pills
Compound Salviae Miltiorrhizae extract 75g, borneol 7.5g, PEG 8000 165g are taken, compound Danshen Root droplet ball is prepared into, is made
Preparation Method is as follows：
After compound Salviae Miltiorrhizae extract powder is added water, stirred 10 minutes in 60 DEG C or more, obtain pharmaceutical premixed material.
(1) material step：
Compound Salviae Miltiorrhizae extract is put into 2500rpm homogeneous in homogenizer with PEG 8000 to mix, the time
100min, then 6000rpm homogeneous material, time 50min, obtain intermediate feed liquid by 80 DEG C of temperature；
(2) dripping step：Intermediate feed liquid vibrates dripping, vibration frequency 140Hz through water dropper, and dripping pressure is
0.5Bar, 100 DEG C of water dropper temperature, dripping speed and step (1) material speeds match are 30kg/hr；
(3) condensing steps：The medicine oozed drips the dripping pill vegetable pill for being quickly cooled down in cooling gas and being frozen into that diameter is 2mm,
The cooling gas temperature is -100 DEG C.
(4) drying steps：It is dry using fluidization drying apparatus, 100 DEG C drying 1 hour, obtain dry dripping pill vegetable pill.
(5) coating steps：The drying vegetable pill is coated in a fluidized bed, and coating material and vegetable pill weight ratio are 1：25,
Coating solution concentration is 10%, and 40 DEG C of temperature are coated up to coated drop pill.
Embodiment seven prepares compound danshen dripping pills
Compound Salviae Miltiorrhizae extract 90g, borneol 2g, cetomacrogol 1000 270g are taken, compound Danshen Root droplet ball is prepared into, is prepared
Method is as follows：
After compound Danshen Root powdered active ingredient is added water, stirred 10 minutes in 30 DEG C or more, obtain pharmaceutical premixed material.
(1) material step：Compound Salviae Miltiorrhizae extract is put into 2500rpm homogeneous in homogenizer with cetomacrogol 1000 to mix
It closes, time 100min, then 6000rpm homogeneous material, time 20min, obtain intermediate feed liquid by 100 DEG C of temperature；
(2) dripping step：Intermediate feed liquid vibrates dripping, vibration frequency 100HZ, acceleration 1G, dripping speed through water dropper
10Kg/hr, dripping pressure 1.0Bar, 75 DEG C of water dropper temperature.
Dripping speed and step (1) material speeds match；
(3) condensing steps：The medicine oozed drips the dripping pill element for being quickly cooled down in cooling gas and being frozen into that diameter is 1.5mm
Ball, the cooling gas temperature are -80 DEG C.
(4) drying steps：It is dry to use gradient increased temperature seasoning, -20 DEG C of are formationed fluidisation states, 15 DEG C drying 10 minutes, 35
DEG C dry 10 minutes, obtain dry dripping pill vegetable pill.
(5) coating steps：The drying vegetable pill is coated in a fluidized bed, and coating material and vegetable pill weight ratio are 1：25,
Coating solution concentration is 10%, and 40 DEG C of temperature are coated up to coated drop pill.
Embodiment eight prepares compound danshen dripping pills
Take compound Salviae Miltiorrhizae extract 100g, borneol 5g, Macrogol 4000 and Macrogol 6000=1:1 combination 35g,
It is prepared into compound Danshen Root droplet ball, preparation method is as follows：
After compound Salviae Miltiorrhizae extract powder is added water, stirred 10 minutes in 80 DEG C or more, obtain pharmaceutical premixed material.
(1) material step：By compound Salviae Miltiorrhizae extract and Macrogol 4000 and Macrogol 6000=1:1 combination is thrown
Enter into homogenizer 2500rpm homogeneous to mix, time 100min, then 6000rpm homogeneous material, time 80min, temperature 80
DEG C, obtain intermediate feed liquid；
(2) dripping step：Intermediate feed liquid vibrates dripping, vibration frequency 200HZ, acceleration 20G, dripping speed through water dropper
40Kg/hr, dripping pressure 3.0Bar, 85 DEG C of water dropper temperature.
Dripping speed and step (1) material speeds match；
(3) condensing steps：The medicine oozed drips the dripping pill element for being quickly cooled down in cooling gas and being frozen into that diameter is 0.5mm
Ball, the cooling gas temperature are 120 DEG C.
(4) drying steps：It is dry to use gradient increased temperature seasoning, 30 DEG C of are formationed fluidisation states, 35 DEG C drying 120 minutes, 55
DEG C dry 60 minutes, 100 DEG C drying 60 minutes, obtain dry dripping pill vegetable pill.
(5) coating steps：The drying vegetable pill is coated in a fluidized bed, and coating material and vegetable pill weight ratio are 1：25,
Coating solution concentration is 10%, and 40 DEG C of temperature are coated up to coated drop pill.
In conclusion the present invention uses oscillatory shear dripping, dripping pill forming speed and dripping pill circularity are improved, and reduce dripping pill
Weight differential；It is monitored in real time while dripping, by the adjusting of parameters, improves dripping pill product yield；Utilize gas
Cold mode realizes dripping pill preparation and improves drugloading rate while high speed dripping pellet, and supplementary product consumption is greatly lowered and takes agent
Amount；Avoid the organic solvent residual of traditional liquid cooling mode.The present invention effectively avoid traditional drilling pill device there are the drawbacks of, really reach
To low energy consumption, high speed, efficiently, high drug load, have widely can dripping range, be greatly improved speed of production and dripping effect
Fruit.
Claims (15)
1. a kind of air cooling dripping pill production line, including dripping pill system, the air cooling circulatory system and control system, dripping pill system include material
Tank and coupled water dropper are equipped with vibration device between the material tank and water dropper, vibration device drives water dropper to vibrate up and down,
The medical fluid flowed out in water dropper is cut into drop by the nibbling shear shear force of generation, forms dripping pill after falling into air cooling circulatory system cooling,
It is characterized in that, the water dropper mainly includes drip tray, and drip tray is equipped with multiple drip hole, and the periphery of drip hole offers spill annular groove.
2. air cooling dripping pill production line as described in claim 1, which is characterized in that the internal diameter of the spill annular groove=drip hole internal diameter
+ 0.4 millimeter, outer diameter >=1.5 millimeter, groove depth is 0.5-5 millimeters.
3. air cooling dripping pill production line as described in claim 1, which is characterized in that the water dropper is equipped with on-Line Monitor Device,
The device includes pulse signal trigger mechanism, the tranmitting frequency of the pulse signal trigger mechanism and the vibration of the vibration device
Frequency is identical, and control system controls to adjust dripping parameter according to the monitoring result of on-Line Monitor Device.
4. air cooling dripping pill production line as claimed in claim 3, which is characterized in that the on-Line Monitor Device is arranged in the drop
The side of head lower section；
The pulse signal trigger mechanism is stroboscopic lamp, and the stroboscopic lamp is identical with the vibration frequency of vibration device；
The on-Line Monitor Device further includes the camera being correspondingly arranged with stroboscopic lamp, and camera and stroboscopic lamp are in same level
It on face, and is in 15 ° of -145 ° of angles with stroboscopic light irradiation route.
5. air cooling dripping pill production line as claimed in claim 3, which is characterized in that the dripping parameter mainly includes：
The vibration frequency of the stroboscopic lamp and vibration device：50-300HZ；
Dripping speed：10-40Kg/hr；
Dripping acceleration：1-20G；
Dripping pressure：0.5-4.0Bar；
Water dropper temperature：70-200℃.
6. air cooling dripping pill production line as claimed in claim 5, which is characterized in that
The vibration frequency of the stroboscopic lamp and vibration device is 90-200Hz；
Dripping speed is 12-30Kg/hr；
Dripping acceleration is 3-10G；
Dripping pressure is 1.0-3.0Bar；
Water dropper temperature is 70-100 DEG C.
7. air cooling dripping pill production line as claimed in claim 6, which is characterized in that
The vibration frequency of the stroboscopic lamp and vibration device is 130-140HZ；
Dripping speed is 15-25Kg/hr；
Dripping acceleration is 3.5-4.5G；
Dripping pressure is 1.8Bar；
Water dropper temperature is 75-85 DEG C.
8. air cooling dripping pill production line as described in claim 1, which is characterized in that be equipped with incubation cavity, institute outside the water dropper
The outer layer for stating incubation cavity is equipped with heat-barrier material, and internal layer is equipped with steam heater or infrared heating device, sets below incubation cavity
There is opening, the position of opening and the outlet port of water dropper are correspondingly arranged, and the size of opening and the width of water dropper are correspondingly arranged.
9. air cooling dripping pill production line as described in claim 1, which is characterized in that the air cooling circulatory system includes：Cooling tube
Road, and connect with the cooling pipe and to the refrigerating plant of cooling pipe refrigeration, the cooling pipe is externally provided with interlayer, institute
Interlayer lower part is stated by being connected to inside communication port and cooling pipe；
The refrigerating plant includes：Cold wind refrigerating plant and cold-trap refrigerating plant, wherein：
The cold wind refrigerating plant includes：Freezer, the air outlet of the freezer are connected with the cold air inlet of cooling pipe, make
Cold wind recycles rising in cooling pipe inner cavity；
The cold-trap refrigerating plant includes：Coolant storage tank equipped with refrigerant, and freeze to the refrigerant in coolant storage tank
Refrigeration machine and heat exchanger, the refrigerant exit of the coolant storage tank are connected with the refrigerant inlet that the interlayer top is arranged, and refrigerant is logical
It crosses in refrigerant inlet input interlayer, is transmitted to interlayer lower part from interlayer top and is transferred in cooling pipe inner cavity；The refrigerant
It recycles rising simultaneously with cold wind in the inner cavity of cooling pipe, and passes through cooling pipe top discharge or recycling；
The cooling pipe is straight barrel type or spiral type pipe, and length is 5-10 meters.
10. air cooling dripping pill production line as claimed in claim 9, which is characterized in that the length of the cooling pipe is 6 meters.
11. air cooling dripping pill production line as claimed in claim 9, which is characterized in that the cooling pipe is equipped with on-line cleaning
Equipment, including：Cleaning unit, control unit, elevation driving unit and lifting unit, described control unit are single by lifting driving
Member driving lifting unit drives cleaning unit lifting, and the cooling pipe top outer of cooling device is arranged in the lifting unit；
The lifting unit includes：Cleaning unit support frame, cleaning pipeline, cleaning pipeline support frame, cleaning pipeline storage tray and
Sealing adapter tube；The cleaning pipeline support frame extends to cleaning pipeline inside cooling pipe；The cleaning unit bracket includes
Multiple support wheels, each described support wheel are supported with cooling pipe inner sidewall, and the cleaning unit prolongs with the cleaning pipeline
One end connection inside cooling pipe is reached, and so that cleaning unit is prolonged the lifting of cooling pipe center by cleaning unit support frame；
One end of the sealing adapter tube is connect with the other end of cleaning pipeline, for importing cleaning solution in the cleaning pipeline；
The lifting unit further includes：On-Line Monitor Device, the on-Line Monitor Device include：Image acquisition units and calculating are single
Member, described image acquisition unit are set on the cleaning unit, and for acquiring the realtime graphic in cooling pipe, image is believed
Number be sent to computing unit, the computing unit according to the picture signal be converted to numerical value and and threshold value comparison, if the numerical value is big
In threshold value, then driving signal is sent to control unit and the cleaning unit is driven to be cleaned.
12. air cooling dripping pill production line as described in claim 1, which is characterized in that the air cooling dripping pill production line further includes fluidisation
Dry coationg system, the system mainly include fluidized bed, and the end of the cooling pipe is entered by vacuum pipe and fluidized bed
Mouth is connected, and will input fluidized drying in fluidized bed by the dripping pill vegetable pill vacuum feeding of air cooling sizing and be coated；
The fluidized bed includes furnace body, is equipped with material feed inlet below furnace body, is equipped with air flow method in the lower section of the feed inlet
The bottom of plate, the airflow-distribution board is connected with the wind pipe of room temperature low humidity supply air system, room temperature low humidity air-supply system
Room temperature low humidity gas is sent into fluid bed furnace body by system by wind pipe, and is fluidized to the material for being built in furnace interior
It is dried；
The room temperature low humidity supply air system includes shell and setting in the intracorporal low humidity unit of shell, shell be equipped with intake stack and
Wind pipe, air after the processing of low humidity unit through wind pipe input the furnace body after entering shell from intake stack；
The room temperature low humidity supply air system further includes the return air duct for air flow recovery, both ends respectively with the furnace body and shell
Body is connected.
13. air cooling dripping pill production line as claimed in claim 12, which is characterized in that the drying temperature of the fluidized bed is -20
DEG C -100 DEG C, drying time is 1-4 hours.
14. air cooling dripping pill production line as claimed in claim 13, which is characterized in that
The fluidized bed uses gradient increased temperature seasoning, and -20-30 DEG C of formation fluidize state, and 15-35 DEG C 10-120 minutes dry, 35-
55 DEG C 10-60 minutes dry, and 55-100 DEG C 0-60 minutes dry.
15. air cooling dripping pill production line as claimed in claim 14, which is characterized in that
The fluidized bed fluidizes state in 0-20 DEG C of formation, 25 DEG C drying 60 minutes, 45 DEG C drying 30 minutes, 55 DEG C of dry 0-30 divide
Clock.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410331055.0A CN104274326B (en) | 2013-07-11 | 2014-07-11 | Be gas-cooled dripping pill production line |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310290968 | 2013-07-11 | ||
| CN201310290968.8 | 2013-07-11 | ||
| CN2013102909688 | 2013-07-11 | ||
| CN201410331055.0A CN104274326B (en) | 2013-07-11 | 2014-07-11 | Be gas-cooled dripping pill production line |
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| Publication Number | Publication Date |
|---|---|
| CN104274326A CN104274326A (en) | 2015-01-14 |
| CN104274326B true CN104274326B (en) | 2018-11-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410330430.XA Active CN104274320B (en) | 2013-07-11 | 2014-07-11 | Dripping pill air cooling circulator and the dripping pill production line with the air cooling circulator |
| CN201410330551.4A Active CN104274321B (en) | 2013-07-11 | 2014-07-11 | Be gas-cooled dripping pill production line |
| CN201410331055.0A Active CN104274326B (en) | 2013-07-11 | 2014-07-11 | Be gas-cooled dripping pill production line |
| CN201410330969.5A Active CN104274519B (en) | 2013-07-11 | 2014-07-11 | Vibratory drilling method prepares compound danshen dripping pills |
| CN201420387451.0U Active CN204147280U (en) | 2013-07-11 | 2014-07-11 | Air cooling dripping pill production line |
| CN201410330554.8A Active CN104274324B (en) | 2013-07-11 | 2014-07-11 | Dripping pill air cooling production line |
| CN201420384495.8U Active CN204147279U (en) | 2013-07-11 | 2014-07-11 | Air cooling dripping pill production line |
| CN201410330970.8A Active CN104274325B (en) | 2013-07-11 | 2014-07-11 | Be gas-cooled dripping pill production line |
| CN201410334580.8A Active CN104274328B (en) | 2013-07-11 | 2014-07-11 | Be gas-cooled dripping pill production line |
| CN201410331026.4A Pending CN104275334A (en) | 2013-07-11 | 2014-07-11 | On-line cleaning equipment for dropping pill cooling device and cleaning method of on-line cleaning equipment |
| CN201420384494.3U Withdrawn - After Issue CN204233449U (en) | 2013-07-11 | 2014-07-11 | Drop pill air cooling production line |
| CN201410331271.5A Pending CN104279840A (en) | 2013-07-11 | 2014-07-11 | Fluidized bed for drop pill drying |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410330430.XA Active CN104274320B (en) | 2013-07-11 | 2014-07-11 | Dripping pill air cooling circulator and the dripping pill production line with the air cooling circulator |
| CN201410330551.4A Active CN104274321B (en) | 2013-07-11 | 2014-07-11 | Be gas-cooled dripping pill production line |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410330969.5A Active CN104274519B (en) | 2013-07-11 | 2014-07-11 | Vibratory drilling method prepares compound danshen dripping pills |
| CN201420387451.0U Active CN204147280U (en) | 2013-07-11 | 2014-07-11 | Air cooling dripping pill production line |
| CN201410330554.8A Active CN104274324B (en) | 2013-07-11 | 2014-07-11 | Dripping pill air cooling production line |
| CN201420384495.8U Active CN204147279U (en) | 2013-07-11 | 2014-07-11 | Air cooling dripping pill production line |
| CN201410330970.8A Active CN104274325B (en) | 2013-07-11 | 2014-07-11 | Be gas-cooled dripping pill production line |
| CN201410334580.8A Active CN104274328B (en) | 2013-07-11 | 2014-07-11 | Be gas-cooled dripping pill production line |
| CN201410331026.4A Pending CN104275334A (en) | 2013-07-11 | 2014-07-11 | On-line cleaning equipment for dropping pill cooling device and cleaning method of on-line cleaning equipment |
| CN201420384494.3U Withdrawn - After Issue CN204233449U (en) | 2013-07-11 | 2014-07-11 | Drop pill air cooling production line |
| CN201410331271.5A Pending CN104279840A (en) | 2013-07-11 | 2014-07-11 | Fluidized bed for drop pill drying |
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| US (1) | US10111811B2 (en) |
| EP (1) | EP3020387B1 (en) |
| JP (1) | JP6426166B2 (en) |
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Also Published As
| Publication number | Publication date |
|---|---|
| CN104274320B (en) | 2018-10-30 |
| CN104274519B (en) | 2018-04-03 |
| CN204147280U (en) | 2015-02-11 |
| US20160166472A1 (en) | 2016-06-16 |
| CN104274325A (en) | 2015-01-14 |
| HK1221396A1 (en) | 2017-06-02 |
| CN104274321B (en) | 2019-11-15 |
| CN104274325B (en) | 2019-06-25 |
| CN104274320A (en) | 2015-01-14 |
| CN104274328B (en) | 2019-07-30 |
| JP2016525392A (en) | 2016-08-25 |
| CN104279840A (en) | 2015-01-14 |
| CN104274324B (en) | 2019-08-27 |
| CN204147279U (en) | 2015-02-11 |
| US10111811B2 (en) | 2018-10-30 |
| EP3020387A4 (en) | 2018-01-10 |
| JP6426166B2 (en) | 2018-11-21 |
| CN104274326A (en) | 2015-01-14 |
| CN204233449U (en) | 2015-04-01 |
| CN104274321A (en) | 2015-01-14 |
| EP3020387A1 (en) | 2016-05-18 |
| CN104274519A (en) | 2015-01-14 |
| EP3020387B1 (en) | 2020-07-01 |
| CN104275334A (en) | 2015-01-14 |
| WO2015003660A1 (en) | 2015-01-15 |
| CN104274324A (en) | 2015-01-14 |
| CN104274328A (en) | 2015-01-14 |
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