CN101279220B - Method for preparing dropping pill using cool air and equipment using the method - Google Patents
Method for preparing dropping pill using cool air and equipment using the method Download PDFInfo
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- CN101279220B CN101279220B CN2007100606401A CN200710060640A CN101279220B CN 101279220 B CN101279220 B CN 101279220B CN 2007100606401 A CN2007100606401 A CN 2007100606401A CN 200710060640 A CN200710060640 A CN 200710060640A CN 101279220 B CN101279220 B CN 101279220B
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- water dropper
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- air
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- 239000006187 pill Substances 0.000 title claims abstract description 66
- 238000000034 method Methods 0.000 title claims abstract description 30
- 238000001816 cooling Methods 0.000 claims abstract description 107
- 239000007788 liquid Substances 0.000 claims abstract description 53
- 239000003814 drug Substances 0.000 claims abstract description 26
- 238000005057 refrigeration Methods 0.000 claims abstract description 14
- 238000010438 heat treatment Methods 0.000 claims abstract description 9
- 239000007787 solid Substances 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 92
- 238000011534 incubation Methods 0.000 claims description 28
- 239000000463 material Substances 0.000 claims description 23
- 235000014347 soups Nutrition 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 6
- 238000007789 sealing Methods 0.000 claims description 6
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- 238000002360 preparation method Methods 0.000 description 10
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- 239000000284 extract Substances 0.000 description 5
- 244000132619 red sage Species 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 description 4
- BOJKULTULYSRAS-OTESTREVSA-N Andrographolide Chemical compound C([C@H]1[C@]2(C)CC[C@@H](O)[C@]([C@H]2CCC1=C)(CO)C)\C=C1/[C@H](O)COC1=O BOJKULTULYSRAS-OTESTREVSA-N 0.000 description 3
- ASLUCFFROXVMFL-UHFFFAOYSA-N andrographolide Natural products CC1(CO)C(O)CCC2(C)C(CC=C3/C(O)OCC3=O)C(=C)CCC12 ASLUCFFROXVMFL-UHFFFAOYSA-N 0.000 description 3
- 239000001335 perilla frutescens leaf extract Substances 0.000 description 3
- 239000001738 pogostemon cablin oil Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 239000009636 Huang Qi Substances 0.000 description 2
- 102000004317 Lyases Human genes 0.000 description 2
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- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 1
- WTPPRJKFRFIQKT-UHFFFAOYSA-N 1,6-dimethyl-8,9-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione;1-methyl-6-methylidene-8,9-dihydro-7h-naphtho[1,2-g][1]benzofuran-10,11-dione Chemical compound O=C1C(=O)C2=C3CCCC(=C)C3=CC=C2C2=C1C(C)=CO2.O=C1C(=O)C2=C3CCC=C(C)C3=CC=C2C2=C1C(C)=CO2 WTPPRJKFRFIQKT-UHFFFAOYSA-N 0.000 description 1
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- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 1
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- Thermotherapy And Cooling Therapy Devices (AREA)
Abstract
The present invention relates to a method for preparing pills by using an air coolant and a device using the method, wherein, the method includes the following steps: heating drugs and accessories in a melting can to be an even liquid, transferring the even liquid to a dripper arranged in a heat preserving chamber, dripping the mixed liquid from the dripper into a cooling duct, starting a refrigerating mode at the same time when the liquid drips so as to maintain the air in the cooling duct at a temperature that the drug drops can be solidified, so that the drug liquid can be cooled and solidified into solid particles in the cooling duct and be dropped into a collecting vessel through an outlet at the lower end of the cooling duct. The device comprises a pill device, a cooling duct hermetically communicated with the pill device and a gas refrigeration device communicated with the cooling duct and circularly conveying cooling air to the cooling duct. The method can avoid the subsequent residual solution process in the traditional condensing way by adopting liquids like whiteruss, silicone oil and so on, having no organic solvent residual and reducing the cost for preparing the pills. The device is characterized by having no dead angle for cleaning, being convenient for cleaning and being able to avoid the cross contamination in the production process, which is beneficial for the stability of the product.
Description
Technical field
The present invention relates to a kind of pharmaceutical methods and equipment thereof.It is simple particularly to relate to a kind of preparation section, does not have organic residue problem, no cross pollution hidden danger, and the utilization of being convenient to clean cooling air prepares the method for dripping pill and uses the equipment of its method.
Background technology
The preparation of tradition dripping pill is to adopt will to melt material and drip to the not miscible liquid lyase of material and obtain, and cools off lyase and can be water-soluble solvent and oil-dissolving solvent.Wherein water-soluble solvent mostly is water, glycerine etc.; Oil-dissolving solvent mostly is paraffin oil and silicone oil.The dripping pill that adopts the oil-dissolving solvent cooling to make, cooling fluid is residual to be unavoidable problem.Follow-uply get rid of oil, the operation of polishing is indispensable, but can not solve organic residue problem; Simultaneously, because the adhesion of cooling fluid such as silicone oil makes equipment can't obtain to clean fully, becoming the hidden danger of cross pollution, is the problem that faces of GMP enterprise now.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of preparation section simple, do not have organic residue problem, no cross pollution hidden danger, and the utilization of being convenient to clean cooling air prepares the method for dripping pill and uses the equipment of its method.
The technical solution adopted in the present invention is: a kind of equipment that utilizes the cooling air to prepare the method for dripping pill and use its method.Wherein, utilize the cooling air to prepare the method for dripping pill, comprise the steps:
1) with in medicine and putting of the auxiliary material batch can, mix, heating makes it become uniform liquid;
2) soup that will melt is transported in the water dropper that is arranged in the incubation cavity, and described water dropper has the outlet with incubation cavity bottom opening equidirectional;
3) make in liquid that medicine and auxiliary material mix oozes upper port and cooling pipe that the incubation cavity bottom opening is connected from the outlet at bottom of water dropper, when liquid oozes, start refrigeration mode and gas in the cooling pipe is remained on make medicine liquid droplet be frozen into solid-state temperature, make the medicine liquid droplet cooled and solidified in cooling pipe that oozes from water dropper become solid granulates and wander in the collecting vessel from the outlet of cooling pipe lower end.
Gas temperature in the described cooling pipe is below 0 ℃.
Can also be in the 3rd step according to the size of required dripping pill, the mode of employing gravity, pressure or pneumatic or electric vibrating is vibrated water dropper makes the medicine liquid droplet that oozes from water dropper reach required diameter.
Use utilization of the present invention cooling air prepares the equipment of the method for dripping pill, includes: dripping pill device, the cooling pipe that is communicated with the sealing of dripping pill device, and be communicated with cooling pipe and the gas refrigeration device of in the cooling pipe conveying cold air of circulating.
Described dripping pill device includes: the change batch can that is connected with the pipeline of feed liquid conveying device; The water dropper that is communicated with the change batch can; Be arranged on the incubation cavity that the water dropper outside is incubated water dropper.
Described water dropper is the funnel-shaped structure of upper and lower perforation, and has identical shaped two-layerly from outside to inside, is fixedly connected by support between two-layer.Corresponding with water dropper, describedization batch can also is provided with two, and each changes the corresponding one deck that is communicated with water dropper of batch can.
Described incubation cavity skin is a heat-barrier material, internal layer is a kind of in steam heater or electric heater unit or the infrared heating device, be formed with opening at incubation cavity corresponding to the following exit of water dropper, the width size of described openings of sizes and water dropper is corresponding, and is tightly connected with the upper port of cooling pipe.The top of described incubation cavity also is provided with vibrating device, and the top that described vibrating device passes incubation cavity links to each other with water dropper, is used for water dropper is produced vibration.
Described cooling pipe is the straight barrel type pipeline, and the upper port of cooling pipe is communicated with the opening sealing of the incubation cavity lower end of dripping pill device, and the lower end of cooling pipe is and the corresponding hatch frame of dripping pill collecting vessel.
Described gas refrigeration device is the cold wind structure, include: inside is provided with the freezer of compressor, the cold gas exhausting outlet of freezer is connected with the upper and lower air inlet of cooling pipe by lateral line, blast pipe respectively, and the gas inflow entrance of freezer is connected with the air outlet of cooling pipe by backwind tube.
Described blast pipe and horizontal plane angle a are 0-90 °, are tangent line with the bucket wall and enter.
Utilization cooling air of the present invention prepares the method for dripping pill and uses the equipment of its method, adopt gas cooled mode dripping pill, can avoid the follow-up residual solvent of condenses modes such as traditional employing atoleine and silicone oil to handle formality, as follow-up de-oiling treatment step, simplified operational sequence, organic solvent-free is residual fully, and has reduced the cost of dripping pill preparation.Equipment adopts the design of straight bobbin road, does not have the cleaning dead angle, and it is convenient to clean, and is convenient to clearing out a gathering place of GMP enterprise, avoids the cross pollution in the production process, is beneficial to the stable of product.
Description of drawings
Fig. 1 is the structural representation of present device;
Fig. 2 is the structural representation of the water dropper in the present device;
Wherein:
1: dripping pill device 2: cooling pipe
3: gas refrigeration device 4: change batch can
5: water dropper 6: incubation cavity
7: pipeline 8: vibrating device
9: compressor 10: freezer
11: blast pipe 12: backwind tube
13: lateral line 14: skin
15: nexine 16: support
The specific embodiment
Below in conjunction with drawings and Examples utilization cooling air of the present invention is prepared the method for dripping pill and uses the equipment of its method to make a detailed description.
Utilization cooling air of the present invention prepares the method for dripping pill, is to adopt cryogenic gas as cooling medium, and typical temperature is lower than 0 ℃, contacts with the dripping pill auxiliary material of fusion, it is cooled to below the freezing point, to guarantee the dripping pill moulding.Usually dripping pill is according to the gravity free-falling, and cooling air is blown into by the bottom, finishes thermal energy exchange with the whereabouts dripping pill.Described cooling air adopts clean the filtration, reaches the requirement of medicine neatness standard fully, needn't worry that medicine is contaminated, and simultaneously, pipeline is more easy to clean, does not have the dead angle of cleaning.
Utilization cooling air of the present invention prepares the method for dripping pill, specifically comprises the steps:
1) with in medicine and putting into of the auxiliary material batch can, be heated to 40-180 ℃ and it mixed be fused into liquid, can be heated to it according to the fusing point of different pharmaceutical and auxiliary material and melt fully and get final product.
2) soup that will melt is transported in the water dropper that is arranged in the incubation cavity, and described water dropper has the outlet with incubation cavity bottom opening equidirectional, guarantees that soup can ooze from the water dropper bottom.
3) liquid that medicine mixes with auxiliary material is oozed in the cooling pipe from the outlet at bottom of water dropper, the upper port of this cooling pipe is connected with the incubation cavity bottom opening, when liquid oozes, start refrigeration mode and gas in the cooling pipe is remained on make medicine liquid droplet be frozen into solid-state temperature, make the medicine liquid droplet cooled and solidified in cooling pipe that oozes from water dropper become solid granulates and wander in the collecting vessel from the outlet of cooling pipe lower end.In this step, can also adopt the pneumatic or electronic mode of vibration vibration water dropper of pressure to make the soup tear drop that oozes from water dropper reach required diameter according to the size of required dripping pill.
Gas temperature in the described cooling pipe is below 0 ℃.
As shown in Figure 1, use utilization cooling air of the present invention prepares the equipment of the method for dripping pill, include: dripping pill device 1, the cooling pipe 2 that is communicated with dripping pill device 1 sealing, and be communicated with cooling pipe 2 and the gas refrigeration device 3 of in the cooling pipe 2 conveying cold air of circulating.
Described dripping pill device 1 includes: the change batch can 4 that is connected with the pipeline 7 of feed liquid conveying device; The water dropper 5 that is communicated with change batch can 4; Be arranged on the incubation cavity 6 that water dropper 5 outsides are incubated water dropper 5.Wherein, described feed liquid conveying device can adopt the gas pressurized mode to pressurize to changing batch can 4 by pipeline 7, finish material from changing the transfer of batch can, also can adopt air pump to finish material from changing the transfer of batch can 4 to changing batch can 4 pressurizations to water dropper 5 by pipeline 7 to water dropper.
Describedization batch can 4 adopts the tank body of prior art, possesses dog-house, stirring, gas pressurized, feed liquid conveyance conduit connection water dropper.Change batch can 4 and adopt the oil bath mode of heating, temperature is controlled at 40-180 ℃, and temperature is even, and the outside has heat-insulation layer.
Described incubation cavity 6 skins are heat-barrier material, internal layer is a kind of in steam heater or electric heater unit or the infrared heating device, be formed with opening at incubation cavity 6 corresponding to the following exit of water dropper 5, the width size of described openings of sizes and water dropper 5 is corresponding, and is tightly connected with the upper port of cooling pipe 2.
As shown in Figure 2, described water dropper 5 is the funnel-shaped structure of upper and lower perforation, and has identical shaped two-layerly from outside to inside, is fixedly connected by supporting 16 between two-layer.Shown in the figure is 2 layers of structure that adopt skin 14 and nexine 15.At this moment change that batch can 4 and water dropper 5 are corresponding also can be provided with two, each changes batch can 4 corresponding one decks that are communicated with water droppers 5.
For under identical water dropper diameter, the dripping pill that acquisition varies in size, the top of described incubation cavity 6 also is provided with vibrating device 8, and the top that described vibrating device 8 passes incubation cavity 6 links to each other with water dropper 5, is used for water dropper 5 is produced vibration.At different material, adopt different mode of vibration vibration water droppers 5, by the adjusting of different vibration frequencies, can obtain the dripping pill of required size.Its mode of vibration can adopt:
The mode of electric vibrating has the high 2-2000Hz of vibration frequency, the characteristics that amplitude is little, the high speed dripping pill mode of suitable low-viscosity material.
The mode of pneumatic vibration, vibration frequency 2-90Hz, amplitude is big.When the material viscosity surpasses 800cp, electronic mode can't effectively be cut material, causes water dropper to stop up, and when influencing dripping pill and preparing, can adopt the pneumatic vibration mode.
Described cooling pipe 2 is straight barrel type or spiral type pipe, and about long 6m, the upper port of cooling pipe 2 is communicated with the opening sealing of incubation cavity 6 lower ends of dripping pill device 1, and the lower end of cooling pipe 2 is and the corresponding hatch frame of dripping pill collecting vessel.
Described gas refrigeration device 3 is the cold wind structure, includes: inside is provided with the freezer 10 of compressor 9, prepares 3 of cold units in the freezer 10, is equipped with mutually.The cold gas exhausting outlet of freezer 10 is connected with the upper and lower air inlet of cooling pipe 2 by lateral line 13, blast pipe 11 respectively, and the gas inflow entrance of freezer 10 is connected by the air outlet of backwind tube 12 with cooling pipe 2.Described blast pipe 11 is 0-90 ° with the angle of horizontal plane.
Cold air after refrigeration tangentially enters cooling pipe 2 through the bottom of cooling pipe 2, and its top of rising twist by the air outlet inflow backwind tube 12 on cooling pipe 2 tops, flows in the freezers 10 through backwind tube 12 again and carries out kind of refrigeration cycle.
The effect that lateral line 13 is set between the top of freezer 10 and cooling pipe 2 is, cold air through the refrigeration processing, directly rise to place through thinner lateral line 13 apart from water dropper outlet 10cm, directly be blown into the cooling air at an angle, make the medicine that oozes continuously drip the purging of the gas that obtains a small amount of lower temperature, maintain a certain distance, avoid dripping pill even glutinous, influence follow-up moulding in this zone.
Utilization cooling air of the present invention prepares the equipment of dripping pill, can adopt online water purging system, directly carry out the water spray Cleaning for High Capacity from the top, after cleaning end, pigging (pig's head cleaning) system utilizes Compressed Gas promotion pig's head that pipeline is carried out wiped clean from top to bottom, after finishing, pig's head is got back to the cleaning station.By clean hot gas cooling tube is carried out drying, thus reach cleaning purpose.
Be exemplified below in conjunction with method and apparatus of the present invention:
Example 1 preparation compound danshen dripping pills:
Get Salvia miltiorrhiza and Panax notoginseng extract 600g, borneol 5g, and PEG-6000 auxiliary material 2000g.With in the PEG-6000 addingization batch can, be heated to 90 ℃ earlier, fusion in advance adds the Salvia miltiorrhiza and Panax notoginseng extract again, is mixed into liquid.The vibration frequency of regulating the pneumatic vibration water dropper is 50Hz, moist closet adopts the steam jacket insulation, and 80 ℃ of temperature controls are supplied gas in changing batch can by pipeline by air pump, make and melt uniform aforesaid liquid and flow into and ooze in the cooling pipe from the water dropper bottom to water dropper, cooling pipe is perpendicular to the ground; Start cold air, make chilling temperature reach-20 ℃, the angle of cooling air inlet and horizontal plane is 45 °, and cold air is circulated in cooling pipe, make the medicine liquid droplet cooled and solidified in cooling pipe that oozes from water dropper become solid-state dripping pill, and wander in the collecting vessel from the outlet of cooling pipe lower end.
Example 2 preparation Danshen Root dropping balls:
Get Salvia root P.E 600g, add water 60g, add PEG-6000 auxiliary material 1500g, be heated to 90 ℃ in the putting into batch can, make its melt-blended even one-tenth liquid fully.The vibration frequency of regulating the pneumatic vibration water dropper is 20Hz, moist closet adopts infrared heat tracing, 80 ℃ of temperature controls are supplied gas in changing batch can by pipeline by air pump, make to melt uniform aforesaid liquid and flow into and ooze in the cooling pipe from the water dropper bottom to water dropper; When oozing, aforesaid liquid starts cold air, make chilling temperature reach-10 ℃, and cold air is circulated in cooling pipe, the angle of cooling air inlet and horizontal plane is 45 °, make the medicine liquid droplet cooled and solidified in cooling pipe that oozes from water dropper become solid-state dripping pill, and wander in the collecting vessel from the outlet of cooling pipe lower end.
Example 3 preparation ageratum dripping pills:
Get ageratum medicinal extract 200g, patchouli oil 1ml, perilla leaf oil 2ml, Macrogol 600 g in the addingization batch can, is heated to 65-85 ℃ simultaneously, and fusion is mixed into liquid.The vibration frequency of regulating the electric vibrating water dropper is 200Hz, moist closet adopts the insulation of electrical heating chuck, 80 ℃ of temperature controls are supplied gas in changing batch can by pipeline by air pump, make to melt uniform aforesaid liquid and flow into and ooze in the straight barrel type cooling pipe from the water dropper bottom to water dropper; When oozing, aforesaid liquid starts cold air, make chilling temperature reach-20 ℃, the angle of cooling air inlet and horizontal plane is 90 °, and cold air is circulated in cooling pipe, make the medicine liquid droplet cooled and solidified in cooling pipe that oozes from water dropper become solid-state dripping pill, and wander in the collecting vessel from the outlet of cooling pipe lower end.
Example 4 preparation QISHEN YIQI DIWANs:
Get Salvia miltiorrhiza and Panax notoginseng medicinal extract 100g, Radix Astragali extractum 200g, dalbergia wood volatile oil 10g and PEG-6000 auxiliary material 900g.With in the PEG-6000 addingization batch can, be heated to 70-80 ℃, fusion in advance earlier; Add the Radix Astragali and the Salvia miltiorrhiza and Panax notoginseng medicinal extract that mixes again, mix, evenly become liquid.The vibration frequency of regulating the pneumatic vibration water dropper is 50Hz, moist closet adopts the steam jacket insulation, 80 ℃ of temperature controls are supplied gas in changing batch can by pipeline by air pump, make to melt uniform aforesaid liquid and flow into and ooze in the straight barrel type cooling pipe from the water dropper bottom to water dropper; When oozing, aforesaid liquid starts cold air, make chilling temperature reach-40 ℃, the angle of cooling air inlet and horizontal plane is 90 °, and cold air is circulated in cooling pipe, make the medicine liquid droplet cooled and solidified in cooling pipe that oozes from water dropper become solid granulates and wander in the collecting vessel from the outlet of cooling pipe lower end.
Example 5 preparation dripping pills of andrographolide:
Get andrographolide 400g and PEG-6000 auxiliary material 800g, PEG-4000 auxiliary material 800g.With PEG-6000, in the PEG-4000 addingization batch can, be heated to 70-80 ℃, fusion in advance earlier; Add andrographolide again, mix, evenly become liquid.The vibration frequency of regulating the pneumatic vibration water dropper is 30Hz, moist closet adopts the steam jacket insulation, 80 ℃ of temperature controls are supplied gas in changing batch can by pipeline by air pump, make to melt uniform aforesaid liquid and flow into and ooze in the straight barrel type cooling pipe from the water dropper bottom to water dropper; When oozing, aforesaid liquid starts cold air, make chilling temperature reach-20 ℃, the angle of cooling air inlet and horizontal plane is 90 °, and cold air is circulated in cooling pipe, make the medicine liquid droplet cooled and solidified in cooling pipe that oozes from water dropper become solid-state dripping pill, and wander in the collecting vessel from the outlet of cooling pipe lower end.
Example 6 preparation ageratum dripping pills:
Get ageratum medicinal extract 200g, patchouli oil 1ml, perilla leaf oil 2ml, Macrogol 600 g.With ageratum medicinal extract, polyethylene glycol 550g, add in the 1#ization batch can, be heated to 65-85 ℃, fusion is mixed into liquid; Get patchouli oil 1ml, perilla leaf oil 2ml, polyethylene glycol 50g adds in the 2#ization batch can, is heated to 65-85 ℃, and fusion is mixed into liquid.2# jar soup feeds double-deck water dropper internal layer, and 1# jar soup feeds double-deck water dropper skin.The vibration frequency that water dropper is regulated the electric vibrating water dropper is 200Hz, moist closet adopts the insulation of electrical heating chuck, and 80 ℃ of temperature controls are supplied gas in changing batch can by pipeline by air pump, make and melt uniform aforesaid liquid and flow into, and ooze in the straight barrel type cooling pipe from the water dropper bottom to water dropper; When oozing, aforesaid liquid starts cold air, make chilling temperature reach-40 ℃, the angle of cooling air inlet and horizontal plane is 45 °, and cold air is circulated in cooling pipe, make the medicine liquid droplet cooled and solidified in cooling pipe that oozes from water dropper become solid-state dripping pill, and wander in the collecting vessel from the outlet of cooling pipe lower end.
Claims (8)
1. one kind is utilized the equipment that air prepares dripping pill that cools off, the cooling pipe (2) that this equipment includes dripping pill device (1), is communicated with dripping pill device (1) sealing, and be communicated with cooling pipe (2) and the gas refrigeration device (3) of in cooling pipe (2) the conveying cold air of circulating; Wherein said dripping pill device (1) includes: the change batch can (4) that is connected with the pipeline (7) of feed liquid conveying device; The water dropper (5) that is communicated with change batch can (4); Be arranged on the outside incubation cavity (6) that water dropper (5) is incubated of water dropper (5);
It is characterized in that described water dropper (5) is the funnel-shaped structure of upper and lower perforation, and have identical shaped two-layerly from outside to inside, be fixedly connected by supporting (16) between two-layer; Corresponding with water dropper (5), describedization batch can (4) also is provided with two, and each changes the corresponding one deck that is communicated with water dropper (5) of batch can (4).
2. the equipment for preparing dripping pill according to the described utilization cooling of claim 1 air, it is characterized in that, described incubation cavity (6) skin is a heat-barrier material, internal layer is a kind of in steam heater or electric heater unit or the infrared heating device, be formed with opening at incubation cavity (6) corresponding to the following exit of water dropper (5), the width size of described openings of sizes and water dropper (5) is corresponding, and is tightly connected with the upper port of cooling pipe (2); The top of described incubation cavity (6) also is provided with vibrating device (8), and the top that described vibrating device (8) passes incubation cavity (6) links to each other with water dropper (5), is used for water dropper (5) is produced vibration.
3. the equipment for preparing dripping pill according to the described utilization cooling of claim 1 air, it is characterized in that, described cooling pipe (2) is the straight barrel type pipeline, the upper port of cooling pipe (2) is communicated with the opening sealing of incubation cavity (6) lower end of dripping pill device (1), and the lower end of cooling pipe (2) is and the corresponding hatch frame of dripping pill collecting vessel.
4. the equipment for preparing dripping pill according to the described utilization cooling of claim 1 air, it is characterized in that, described gas refrigeration device (3) is the cold wind structure, include: inside is provided with the freezer (10) of compressor (9), the cold gas exhausting outlet of freezer (10) is connected with the upper and lower air inlet of cooling pipe (2) by lateral line (13), blast pipe (11) respectively, and the gas inflow entrance of freezer (10) is connected by the air outlet of backwind tube (12) with cooling pipe (2).
5. prepare the equipment of dripping pill according to the described utilization cooling of claim 4 air, it is characterized in that described blast pipe (11) is 0-90 ° with horizontal plane angle a.
6. an application rights requires any described equipment of 1-5 to prepare the method for dripping pill, and this method comprises the steps:
1) with in medicine and putting of the auxiliary material batch can, mix, heating makes it become uniform liquid;
2) soup that will melt is transported in the water dropper that is arranged in the incubation cavity, and described water dropper has the outlet with incubation cavity bottom opening equidirectional;
3) make in liquid that medicine and auxiliary material mix oozes upper port and cooling pipe that the incubation cavity bottom opening is connected from the outlet at bottom of water dropper, when liquid oozes, start refrigeration mode and gas in the cooling pipe is remained on make medicine liquid droplet be frozen into solid-state temperature, make the medicine liquid droplet cooled and solidified in cooling pipe that oozes from water dropper become solid granulates and wander in the collecting vessel from the outlet of cooling pipe lower end;
It is characterized in that employed water dropper is the funnel-shaped structure of upper and lower perforation, and have identical shaped two-layer from outside to inside; Corresponding with water dropper, be provided with two and change batch can, each changes the corresponding one deck that is communicated with water dropper of batch can.
7. according to the described method for preparing dripping pill of claim 6, it is characterized in that the gas temperature in the described cooling pipe is below 0 ℃.
8. according to the described method for preparing dripping pill of claim 6, it is characterized in that, in the 3rd step, can also adopt mode pneumatic or electric vibrating to vibrate water dropper and make the medicine liquid droplet that oozes from water dropper reach required diameter according to the size of required dripping pill.
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| CN2007100606401A CN101279220B (en) | 2007-12-28 | 2007-12-28 | Method for preparing dropping pill using cool air and equipment using the method |
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| CN2007100606401A CN101279220B (en) | 2007-12-28 | 2007-12-28 | Method for preparing dropping pill using cool air and equipment using the method |
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| CN101279220A CN101279220A (en) | 2008-10-08 |
| CN101279220B true CN101279220B (en) | 2011-06-08 |
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Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101745346B (en) * | 2008-12-03 | 2013-01-23 | 天士力制药集团股份有限公司 | Liquid pill primary separating device |
| CN104274327A (en) * | 2013-07-11 | 2015-01-14 | 天士力制药集团股份有限公司 | Liquid cooling dropping pill production line |
| CN204147280U (en) * | 2013-07-11 | 2015-02-11 | 天士力制药集团股份有限公司 | Air cooling dripping pill production line |
| AU2014289766B2 (en) * | 2013-07-11 | 2019-03-14 | Tasly Pharmaceutical Group Co., Ltd. | Traditional chinese medicine composition, and preparation and application thereof |
| JP6906307B2 (en) | 2013-07-11 | 2021-07-21 | タスリー・ファーマシューティカル・グループ・カンパニー・リミテッドＴａｓｌｙ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｇｒｏｕｐ Ｃｏ．， Ｌｔｄ． | Chinese herbal medicine compositions, their formulations and uses |
| CN104274319A (en) * | 2013-07-11 | 2015-01-14 | 天士力制药集团股份有限公司 | Method for dropping drop pills by vibration |
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| AU2014289765B2 (en) * | 2013-07-11 | 2019-05-09 | Tasly Pharmaceutical Group Co., Ltd. | Preparation method for traditional Chinese medicine micro drop pill and traditional Chinese medicine micro drop pill prepared by using the method |
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| CN106539690B (en) * | 2015-09-18 | 2020-08-04 | 天士力医药集团股份有限公司 | Continuous intelligent preparation method of liquid cooling dropping pills |
| CN110090599A (en) * | 2019-05-20 | 2019-08-06 | 武汉大坦智能装备科技有限公司 | Multistation pill dripping machine |
| CN112109256A (en) * | 2020-09-02 | 2020-12-22 | 福建金闽再造烟叶发展有限公司 | Dripper and capsule dripping system |
| CN115025708B (en) * | 2022-07-15 | 2024-05-14 | 平泉石尚新材料有限公司 | Color sand spraying granulation device and color sand spraying granulation method |
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| CN101279220A (en) | 2008-10-08 |
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