CN104258178A - 一种治疗肺癌胸腔积液的药物及其制备方法 - Google Patents
一种治疗肺癌胸腔积液的药物及其制备方法 Download PDFInfo
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- CN104258178A CN104258178A CN201410449854.8A CN201410449854A CN104258178A CN 104258178 A CN104258178 A CN 104258178A CN 201410449854 A CN201410449854 A CN 201410449854A CN 104258178 A CN104258178 A CN 104258178A
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Abstract
本发明公开了一种治疗肺癌胸腔积液的药物,包括甘遂、大戟、芫花、白芥子、葶苈子、桑白皮、半夏、大枣、猪苓、茯苓、桂枝、车前草、白术、白花蛇舌草、半边莲、薏苡仁、瓜蒌皮、丹参、炙葶苈、马鞭草、苏子、法半夏、刺蒺藜、泽兰、川椒目、橘红、水蛭、薤白、杏仁、甘草、沙参、麦冬、玉竹、天花粉、地骨皮、土鳖、僵蚕、地龙、蟋蟀、蝼蛄、龙葵、干蟾皮、石见穿、苦参、山慈姑、牛蒡子、广豆根、雷公藤、鳖甲、木香、乳香、没药、白术、延胡索和白芍,对肺癌胸水患者有明显的逐水散结作用,同时可以益气止咳化痰、养血活血止痛、软坚散结消癥,从而提高病人生存质量、延长生命,有效率可以达到90%。
Description
技术领域
本发明涉及一种治疗肺癌胸腔积液的药物及其制备方法,属于中医药领域。
背景技术
肺癌是我国最常见恶性肿瘤之一,临床表现主要有咳嗽、痰中带血或咯血、胸痛、胸闷、憋气、声音嘶哑,胸腔积液等。近年来由于吸烟、电离辐射、环境污染加重导致肺癌的发病率明显上升。
晚期肺癌胸膜转移、受侵常表现为胸腔积液,属于恶性胸水的一种,肺癌患者的临床表现可因胸腔积液多寡可所不同,常见的症状有呼吸困难、咳嗽、胸闷与胸痛等,亦可完全无任何症状;查体时可见肋间饱满、肋间增宽、呼吸音减低、语颤减低、叩诊实音、纵隔移位等,胸水可为浆液性、浆液血性或血性,多数为渗出液,恶性胸水的特点为增长速度快,多呈血性。极为罕见的肺癌可发生自发性气胸,其机制为胸膜的直接侵犯和阻塞性肺气肿破裂,多见于鳞癌,预后不良。胸水的成因除直接侵犯和转移外,还包括***的阻塞以及伴发的阻塞性肺炎和肺不张。肺癌胸水症状的出现严重影响着广大肺癌患者的生活质量,同时也增加了中晚期肺癌治疗的难度,严重者会威胁到患者的生命。
在实现本发明的过程中,发明人发现现有技术至少存在以下不足:在治疗肺癌胸腔积液方面,西医尚无良好的疗法,多采用胸水透析、穿刺放水、胸腔腔注药、输白蛋白及利尿剂。虽能暂时解除患者痛苦,但治标不治本,容易反复。首先,应用利尿药物、频繁抽液、腔内注射药物等,往往给患者带来很大的痛苦,且毒副作用巨大,疗效甚微。其次,反复进行抽液过程中丢失大量体液蛋白,使机体更加衰弱,容易合并各种感染从而引起其他器官功能障碍。
目前,在临床上也出现了多种治疗肺癌胸腔积液的中医药物,虽取得了一定疗效,但效果不太理想。
发明内容
本发明要解决的技术问题是针对以上不足,提供一种治疗肺癌胸腔积液的药物,克服现有药物副作用较大,而且时有反复,效果不理想的缺陷,采用本发明所述药物治疗胸腔积液,治疗效果明显。
本发明的另一目的是提供一种治疗肺癌胸腔积液药物的制备方法。
为解决上述技术问题,本发明所采用的技术方案是:一种治疗肺癌胸腔积液的药物,其特征是:所述药物药效成分按重量份包括:甘遂6-10份、大戟6-10份、芫花6-10份、白芥子10-15份、葶苈子12-18份、桑白皮10-14份、半夏9-12份、大枣5-10份、猪苓12-16份、茯苓12-18份、桂枝6-10份、车前草24-28份、白术12-18份、白花蛇舌草15-18份、半边莲15-18份、薏苡仁30-34份、瓜蒌皮15-30份、丹参15-30份、炙葶苈30-40份、马鞭草30-40份、苏子12-18份、法半夏12-18份、刺蒺藜12-18份、泽兰12-18份、川椒目12-18份、橘红9-12份、水蛭6-12份、薤白6-12份、杏仁10-15份、甘草6-12份、沙参10-16份、麦冬15-30份、玉竹15-30份、天花粉15-30份、地骨皮15-30份、土鳖6-10份、僵蚕15-30份、地龙15-30份、蟋蟀15-30份、蝼蛄15-30份、龙葵15-30份、干蟾皮6-10份、石见穿6-10份、苦参6-10份、山慈姑15-30份、牛蒡子15-30份、广豆根15-30份、雷公藤15-30份、鳖甲20-24份、木香10-14份、乳香10-14份、没药15-20份、白术15-20份、延胡索20-25份和白芍15-20份。
发明人在实际工作中,经过大量的研究和试验,发现采用以上有效成分制成的药物在治疗胸腔积液方面,效果非常明显。
一种优化的技术方案,所述药物药效成分按重量份包括:甘遂8-10份、大戟8-10份、芫花8-10份、白芥子12-15份、葶苈子16-18份、桑白皮12-14份、半夏10-12份、大枣8-10份、猪苓14-16份、茯苓16-18份、桂枝8-10份、车前草26-28份、白术16-18份、白花蛇舌草16-18份、半边莲16-18份、薏苡仁32-34份、瓜蒌皮18-30份、丹参18-30份、炙葶苈35-40份、马鞭草35-40份、苏子16-18份、法半夏16-18份、刺蒺藜16-18份、泽兰16-18份、川椒目16-18份、橘红10-12份、水蛭10-12份、薤白10-12份、杏仁12-15份、甘草10-12份、沙参14-16份、麦冬18-30份、玉竹18-30份、天花粉18-30份、地骨皮18-30份、土鳖8-10份、僵蚕18-30份、地龙18-30份、蟋蟀18-30份、蝼蛄18-30份、龙葵18-30份、干蟾皮8-10份、石见穿8-10份、苦参8-10份、山慈姑25-30份、牛蒡子25-30份、广豆根25-30份、雷公藤25-30份、鳖甲22-24份、木香12-14份、乳香12-14份、没药16-20份、白术16-20份、延胡索22-25份和白芍16-20份。
发明人发现采用以上有效成分制成的药物在治疗胸腔积液方面,效果更优。
一种具体的优化方案,所述药物药效成分按重量份包括:
甘遂9份、大戟9份、芫花9份、白芥子10份、葶苈子15份、桑白皮18份、半夏10份、大枣8份、猪苓12份、茯苓10份、桂枝10份、车前草25份、白术16份、白花蛇舌草16份、半边莲17份、薏苡仁25份、瓜蒌皮26份、丹参26份、炙葶苈25份、马鞭草25份、苏子16份、法半夏16份、刺蒺藜16份、泽兰16份、川椒目17份、橘红9份、水蛭9份、薤白9份、杏仁11份、甘草12份、沙参11份、麦冬23份、玉竹23份、天花粉23份、地骨皮23份、土鳖9份、僵蚕13份、地龙13份、蟋蟀18份、蝼蛄18份、龙葵18份、干蟾皮7份、石见穿7份、苦参7份、山慈姑18份、牛蒡子22份、广豆根22份、雷公藤23份、鳖甲13份、木香13份、乳香11份、没药12份、白术13份、延胡索18份和白芍16份。
发明人发现采用以上有效成分制成的药物在治疗胸腔积液方面,效果最优。
以上治疗肺癌胸水药物的制备方法包括:
1)按照重量份分别称取各原料;
2)鳖甲:取鳖甲置缸内或地内,用石灰碱水浸泡10天左右,取出轧破,去净皮肉,用清水冲洗干净,晒干。每鳖甲100吨,用石灰100kg,碱2.5kg;
3)煨木香:麸精将锅以武火加热,置麸皮于锅内,待起烟时,投入木香片,轻轻翻动药片,至片面深黄色,取出,筛去麸皮,木香片与麸皮的重量比为8∶3;
4)制乳香:取净乳香,大者砸成小块,另取沙子置锅内,加热至100℃以上,然后铺上纸2-3层,上摊乳香块,继续加热至出油时,用筷子轻轻翻动,并换纸2-3次,至乳香呈珠状,不粘手为度,取出,放凉;
5)制没药:取净没药,大者砸成小块,置锅内炒至出油时,加入灯心同炒,至油被灯心吸尽,没药膨胀呈球状为度,取出簸去灯心,放凉,没药与灯心的重量比为1∶30;
6)酒延胡索:取净延胡索片或碎块,加黄酒拌匀,闷透,置锅内用文火加热,炒干,取出放凉,延胡索与黄酒的重量比为5∶1;
7)炒白术:将蜜炙麸皮撒入热锅内,待冒烟时加入白术片,炒至焦黄色、逸出焦香气,取出,筛去蜜炙麸皮,白术与蜜炙麸皮的重量比为10∶1;
8)酒白芍:取净白芍片,用黄酒喷洒均匀,稍润后放锅内炒至微黄色,白芍与黄酒的重量比为10∶1;
9)蜜制瓜蒌皮:取炼蜜用适量开水稀释后,加入瓜蒌皮丝,拌匀,焖透,置锅内,用文火加热,炒至黄棕色不粘手为度。取出放凉,瓜蒌皮丝与炼蜜的重量比为4∶1;
10)米制蝼蛄:将锅以武火加热,撒米于锅底,俟起烟时,投入净蝼姑,缓缓翻动3-4遍,取出,拣取蝼蛄。净蝼蛄与米的重量比为3∶16;
11)煅制雷公藤:将雷公藤投入专用的锅内燃烧成炭,然后泼水,不使其化灰。待晒干后,用专用粉碎机研成粉;
12)米制蟋蟀:将锅以武火加热,撒米于锅底,俟起烟时,投入蟋蟀,缓缓翻动3-4遍后,取出,拣取蟋蟀。净蟋蟀与米的重量比为3∶16;
13)将其余的原料和制鳖甲以及煨木香、制乳香、制没药、酒延胡索、炒白术、酒白芍、蜜制瓜蒌皮、米制蝼蛄、煅制雷公藤、米制蟋蟀混合,用粉碎机粉碎,过120目筛成为细末;
14)将以上细末分袋密封包装,密封在瓷罐内,然后将瓷罐埋藏于土壤内,深0.5米,两年后取出烘干,备用;
15)取芸豆用粉碎机粉碎,过100目筛成为细末,加入60℃水浸泡120分钟(水高出细末10cm)并打捞豆皮、去除豆渣,静止60分钟后取含有植物凝集素的上清液,将上清液煮沸30分钟后放凉,再次煮沸,反复进行6次;
16)将药物细末与熬炼好的上清液及蜂蜜按1∶1∶1.5混匀,搓条、和丸得治疗胸腔积液的药物。
在实际应用中,发明人发现经以上方法制备所得药物,在治疗胸腔积液时效果明显。
治疗肺癌胸水药物的使用方法包括以下步骤:
每粒药丸0.3g。
一次30粒,每日三次口服。
以上药物的药理为:
甘遂、大戟、芫花、白芥子、葶苈子、桑白皮、薏苡仁、半边莲、半夏、车前草、蟋蟀、山慈姑、广豆根甘草、僵蚕、杏仁具有化痰、止咳的功效;炒白术、酒白芍、煨木香、茯苓、白花蛇舌草、地骨皮、薤白、制乳香、猪苓、煨木香、制没药、蝼蛄龙葵、雷公藤、牛蒡子、酒延胡索、大枣、苦参、苏子、桂枝、酒延胡索、土鳖、酒白芍、沙参、玉竹、干蟾皮、丹参具有养血活血、散结止痛的功效;瓜蒌皮、制没药、制乳香、炙葶苈马鞭草、法半夏、刺蒺藜、石见穿、泽兰、川椒目、橘红、地龙、鳖甲、水蛭、麦冬、天花粉具有攻逐水饮、消肿散结的功效。以上各成份经本发明方法制备后,相互作用,终使其共同达到消补兼施、利水消结而不伤正气的功效。
本发明采用以上技术方案,对肺癌胸水患者有明显的逐水散结作用,同时可以益气止咳化痰、养血活血止痛、软坚散结消癥,从而提高病人生存质量、延长生命。经试验,有效率可以达到90%。
下面结合实施例对本发明的技术方案进一步的说明。
具体实施方式
实施例1,一种治疗肺癌胸水的药物,药效成分按重量份包括:甘遂6份、大戟6份、芫花10份、白芥子10份、葶苈子12份、桑白皮10份、半夏12份、大枣5份、猪苓12份、茯苓12份、桂枝6份、车前草28份、白术12份、白花蛇舌草15份、半边莲15份、薏苡仁30份、瓜蒌皮15份、丹参30份、炙葶苈30份、马鞭草30份、苏子18份、法半夏12份、刺蒺藜12份、泽兰12份、川椒目18份、橘红9份、水蛭6份、薤白6份、杏仁15份、甘草6份、沙参10份、麦冬15份、玉竹15份、天花粉15份、地骨皮15份、土鳖10份、僵蚕15份、地龙15份、蟋蟀15份、蝼蛄30份、龙葵15份、干蟾皮6份、石见穿10份、苦参6份、山慈姑15份、牛蒡子15份、广豆根15份、雷公藤30份、鳖甲20份、木香10份、乳香10份、没药15份、白术20份、延胡索25份和白芍15份。
实施例2,一种治疗肺癌胸水的药物,药效成分按重量份包括:
甘遂8份、大戟10份、芫花8份、白芥子12份、葶苈子16份、桑白皮12份、半夏10-12份、大枣8-10份、猪苓14-16份、茯苓16-18份、桂枝8-10份、车前草28份、白术16份、白花蛇舌草16份、半边莲18份、薏苡仁32份、瓜蒌皮18份、丹参18份、炙葶苈35份、马鞭草40份、苏子16份、法半夏16份、刺蒺藜16份、泽兰16份、川椒目16份、橘红10份、水蛭12份、薤白10份、杏仁12份、甘草10份、沙参14份、麦冬18份、玉竹18份、天花粉18份、地骨皮18份、土鳖8份、僵蚕18份、地龙18份、蟋蟀18份、蟋蟀18份、蝼蛄18份、干蟾皮8份、石见穿10份、苦参8份、山慈姑25份、牛蒡子25份、广豆根25份、雷公藤25份、鳖甲22份、木香12份、乳香12份、没药16份、白术16份、延胡索22份和白芍16份。
实施例3,一种治疗肺癌胸水的药物,药效成分按重量份包括:甘遂8份、大戟8份、芫花8份、白芥子12份、葶苈子16份、桑白皮15份、半夏8份、大枣6份、猪苓10份、茯苓12份、桂枝12份、车前草26份、白术18份、白花蛇舌草15份、半边莲15份、薏苡仁30份、瓜蒌皮25份、丹参25份、炙葶苈30份、马鞭草30份、苏子15份、法半夏15份、刺蒺藜20份、泽兰15份、川椒目15份、橘红8份、水蛭8份、薤白8份、杏仁12份、甘草15份、沙参10份、麦冬25份、玉竹25份、天花粉22份、地骨皮22份、土鳖8份、僵蚕15份、地龙15份、蟋蟀20份、蝼蛄20份、龙葵20份、干蟾皮8份、石见穿8份、苦参8份、山慈姑20份、牛蒡子25份、广豆根20份、雷公藤20份、鳖甲15份、木香10份、乳香12份、没药15份、白术12份、延胡索20份和白芍18份。
实施例4,一种治疗肺癌胸水的药物,药效成分按重量份包括:甘遂9份、大戟9份、芫花9份、白芥子10份、葶苈子15份、桑白皮18份、半夏10份、大枣8份、猪苓12份、茯苓10份、桂枝10份、车前草25份、白术16份、白花蛇舌草16份、半边莲17份、薏苡仁25份、瓜蒌皮26份、丹参26份、炙葶苈25份、马鞭草25份、苏子16份、法半夏16份、刺蒺藜16份、泽兰16份、川椒目17份、橘红9份、水蛭9份、薤白9份、杏仁11份、甘草12份、沙参11份、麦冬23份、玉竹23份、天花粉23份、地骨皮23份、土鳖9份、僵蚕13份、地龙13份、蟋蟀18份、蝼蛄18份、龙葵18份、干蟾皮7份、石见穿7份、苦参7份、山慈姑18份、牛蒡子22份、广豆根22份、雷公藤23份、鳖甲13份、木香13份、乳香11份、没药12份、白术13份、延胡索18份和白芍16份。
实施例5,一种治疗肺癌胸水的药物,药效成分按重量份包括:甘遂8份、大戟10份、芫花8份、白芥子13份、葶苈子14份、桑白皮17份、半夏12份、大枣9份、猪苓11份、茯苓13份、桂枝14份、车前草24份、白术12份、白花蛇舌草14份、半边莲14份、薏苡仁23份、瓜蒌皮25份、丹参24份、炙葶苈28份、马鞭草28份、苏子17份、法半夏17份、刺蒺藜18份、泽兰18份、川椒目19份、橘红5份、水蛭7份、薤白7份、杏仁13份、甘草15份、沙参14份、麦冬23份、玉竹24份、天花粉24份、地骨皮26份、土鳖10份、僵蚕12份、地龙11份、蟋蟀20份、蝼蛄19份、龙葵19份、干蟾皮9份、石见穿9份、苦参9份、山慈姑17份、牛蒡子24份、广豆根24份、雷公藤24份、鳖甲14份、木香15份、乳香12份、没药14份、白术15份、延胡索17份和白芍18份。
以上实施例的药物分别按照以下步骤制备:
1)按照重量份分别称取各原料;
2)制鳖甲:取鳖甲置缸内或地内,用石灰碱水浸泡10天左右,取出轧破,去净皮肉,用清水冲洗干净,晒干。每鳖甲100吨,用石灰100kg,碱2.5kg;
3)煨木香:麸精将锅以武火加热,置麸皮于锅内,待起烟时,投入木香片,轻轻翻动药片,至片面深黄色,取出,筛去麸皮,木香片与麸皮的重量比为8∶3;
4)制乳香:取净乳香,大者砸成小块,另取沙子置锅内,加热至100℃以上,然后铺上纸2-3层,上摊乳香块,继续加热至出油时,用筷子轻轻翻动,并换纸2-3次,至乳香呈珠状,不粘手为度,取出,放凉;
5)制没药:取净没药,大者砸成小块,置锅内炒至出油时,加入灯心同炒,至油被灯心吸尽,没药膨胀呈球状为度,取出簸去灯心,放凉,没药与灯心的重量比为1∶30;
6)酒延胡索:取净延胡索片或碎块,加黄酒拌匀,闷透,置锅内用文火加热,炒干,取出放凉,延胡索与黄酒的重量比为5∶1;
7)炒白术:将蜜炙麸皮撒入热锅内,待冒烟时加入白术片,炒至焦黄色、逸出焦香气,取出,筛去蜜炙麸皮,白术与蜜炙麸皮的重量比为10∶1;
8)酒白芍:取净白芍片,用黄酒喷洒均匀,稍润后放锅内炒至微黄色,白芍与黄酒的重量比为10∶1;
9)蜜制瓜蒌皮:取炼蜜用适量开水稀释后,加入瓜蒌皮丝,拌匀,焖透,置锅内,用文火加热,炒至黄棕色不粘手为度。取出放凉,瓜蒌皮丝与炼蜜的重量比为4∶1;
10)米制蝼蛄:将锅以武火加热,撒米于锅底,俟起烟时,投入净蝼姑,缓缓翻动3-4遍,取出,拣取蝼蛄。净蝼蛄与米的重量比为3∶16;
11)煅制雷公藤:将雷公藤投入专用的锅内燃烧成炭,然后泼水,不使其化灰。待晒干后,用专用粉碎机研成粉;
12)米制蟋蟀:将锅以武火加热,撒米于锅底,俟起烟时,投入蟋蟀,缓缓翻动3-4遍后,取出,拣取蟋蟀。净蟋蟀与米的重量比为3∶16;
13)将其余的原料和制鳖甲以及煨木香、制乳香、制没药、酒延胡索、炒白术、酒白芍、蜜制瓜蒌皮、米制蝼蛄、煅制雷公藤、米制蟋蟀混合,用粉碎机粉碎,过120目筛成为细末;
14)将以上细末分袋密封包装,密封在瓷罐内,然后将瓷罐埋藏于土壤内,深0.5米,两年后取出烘干,备用;
15)取芸豆用粉碎机粉碎,过100目筛成为细末,加入60℃水浸泡120分钟(水高出细末10cm)并打捞豆皮、去除豆渣,静止60分钟后取含有植物凝集素的上清液,将上清液煮沸30分钟后放凉,再次煮沸,反复进行6次;
16)将药物细末与熬炼好的上清液及蜂蜜按体积比1∶1∶1.5混匀,搓条、和丸得治疗胸腔积液的药物。
在实际应用中,发明人发现经以上方法制备所得药物,在治疗胸腔积液时效果明显。
治疗肺癌胸水药物的使用方法包括以下步骤:
每粒药丸0.3g。
一次30粒,每日三次口服。
将以上五个实施例所得药物用于肺癌胸水的试验,使用疗效评定标准为:
显效:胸水及浮肿完全消退,症状减轻或消失,瘤体缩小;
稳定:胸水未完全消退,B超提示少量胸水,瘤体未见缩小,亦未见增大;
恶化:症状加重、瘤体增大、胸水不退,甚至出现憋气加重、出血、休克现象。
2010年7月至2014年8月就医的300例肺癌胸水患者,患者病症符合《肿瘤内科学》第3版肺癌胸水诊断标准。300例均经病理证实为肺癌,其中252例经B超诊断为肺癌胸水,其余48例具有胸水典型症状。男187例,女113例,年龄40-80岁,病程1个月至2年。
共设置5个试验组,每个试验组随机分配患者进行治疗。试验组1使用实施例1所得的药物治疗,试验组2使用实施例2所得的药物治疗,试验组3使用实施例3所得的药物治疗,试验组4使用实施例4所得的药物治疗,试验组5使用本发明实施例5所得的药物治疗,设50例为对照组,对照组采用西医胸腔注药、胸腔穿刺及输注白蛋白的方法治疗,总有效率40%。
试验得到的结果如下表:
从以上数据看出,本发明所得治疗肺癌胸水的药物,总有效率达到84.0%以上,治疗后1个月电话回访无明显毒副作用,在以上实施例中,实施例4为最佳方案。
本领域技术人员应该认识到,上述的具体实施方式只是示例性的,是为了使本领域技术人员能够更好的理解本发明内容,不应理解为是对本发明保护范围的限制,只要是根据本发明技术方案所作的改进,并实现与本发明的相同的作用,均落入本发明的保护范围。
Claims (4)
1.一种治疗肺癌胸腔积液的药物,其特征在于:所述药物药效成分按重量份包括:
甘遂6-10份、大戟6-10份、芫花6-10份、白芥子10-15份、葶苈子12-18份、桑白皮10-14份、半夏9-12份、大枣5-10份、猪苓12-16份、茯苓12-18份、桂枝6-10份、车前草24-28份、白术12-18份、白花蛇舌草15-18份、半边莲15-18份、薏苡仁30-34份、瓜蒌皮15-30份、丹参15-30份、炙葶苈30-40份、马鞭草30-40份、苏子12-18份、法半夏12-18份、刺蒺藜12-18份、泽兰12-18份、川椒目12-18份、橘红9-12份、水蛭6-12份、薤白6-12份、杏仁10-15份、甘草6-12份、沙参10-16份、麦冬15-30份、玉竹15-30份、天花粉15-30份、地骨皮15-30份、土鳖6-10份、僵蚕15-30份、地龙15-30份、蟋蟀15-30份、蝼蛄15-30份、龙葵15-30份、干蟾皮6-10份、石见穿6-10份、苦参6-10份、山慈姑15-30份、牛蒡子15-30份、广豆根15-30份、雷公藤15-30份、鳖甲20-24份、木香10-14份、乳香10-14份、没药15-20份、白术15-20份、延胡索20-25份和白芍15-20份。
2.如权利要求1所述的药物,其特征在于:所述药物药效成分按重量份包括:
甘遂8-10份、大戟8-10份、芫花8-10份、白芥子12-15份、葶苈子16-18份、桑白皮12-14份、半夏10-12份、大枣8-10份、猪苓14-16份、茯苓16-18份、桂枝8-10份、车前草26-28份、白术16-18份、白花蛇舌草16-18份、半边莲16-18份、薏苡仁32-34份、瓜蒌皮18-30份、丹参18-30份、炙葶苈35-40份、马鞭草35-40份、苏子16-18份、法半夏16-18份、刺蒺藜16-18份、泽兰16-18份、川椒目16-18份、橘红10-12份、水蛭10-12份、薤白10-12份、杏仁12-15份、甘草10-12份、沙参14-16份、麦冬18-30份、玉竹18-30份、天花粉18-30份、地骨皮18-30份、土鳖8-10份、僵蚕18-30份、地龙18-30份、蟋蟀18-30份、蝼蛄18-30份、龙葵18-30份、干蟾皮8-10份、石见穿8-10份、苦参8-10份、山慈姑25-30份、牛蒡子25-30份、广豆根25-30份、雷公藤25-30份、鳖甲22-24份、木香12-14份、乳香12-14份、没药16-20份、白术16-20份、延胡索22-25份和白芍16-20份。
3.如权利要求1所述的药物,其特征在于:所述药物药效成分按重量份包括:
甘遂9份、大戟9份、芫花9份、白芥子10份、葶苈子15份、桑白皮18份、半夏10份、大枣8份、猪苓12份、茯苓10份、桂枝10份、车前草25份、白术16份、白花蛇舌草16份、半边莲17份、薏苡仁25份、瓜蒌皮26份、丹参26份、炙葶苈25份、马鞭草25份、苏子16份、法半夏16份、刺蒺藜16份、泽兰16份、川椒目17份、橘红9份、水蛭9份、薤白9份、杏仁11份、甘草12份、沙参11份、麦冬23份、玉竹23份、天花粉23份、地骨皮23份、土鳖9份、僵蚕13份、地龙13份、蟋蟀18份、蝼蛄18份、龙葵18份、干蟾皮7份、石见穿7份、苦参7份、山慈姑18份、牛蒡子22份、广豆根22份、雷公藤23份、鳖甲13份、木香13份、乳香11份、没药12份、白术13份、延胡索18份和白芍16份。
4.如权利要求1-3所述药物的制备方法,其特征在于:所述制备方法包括以下步骤:
1)按照重量份分别称取各原料;
2)鳖甲:取鳖甲置缸内或地内,用石灰碱水浸泡10天,取出轧破,去净皮肉,用清水冲洗干净,晒干;
3)煨木香:将锅以武火加热,置麸皮于锅内,待起烟时,投入木香片,轻轻翻动药片,至片面深黄色,取出,筛去麸皮,木香片与麸皮的重量比为8∶3;
4)制乳香:取净乳香,大者砸成小块,另取沙子置锅内,加热至100℃以上,然后铺上纸2-3层,上摊乳香块,继续加热至出油时,用筷子轻轻翻动,并换纸2-3次,至乳香呈珠状,不粘手为度,取出,放凉;
5)制没药:取净没药,大者砸成小块,置锅内炒至出油时,加入灯心同炒,至油被灯心吸尽,没药膨胀呈球状为度,取出簸去灯心,放凉,没药与灯心的重量比为1∶30;
6)酒延胡索:取净延胡索片或碎块,加黄酒拌匀,闷透,置锅内用文火加热,炒干,取出放凉,延胡索与黄酒的重量比为5∶1;
7)炒白术:将蜜炙麸皮撒入热锅内,待冒烟时加入白术片,炒至焦黄色、逸出焦香气,取出,筛去蜜炙麸皮,白术与蜜炙麸皮的重量比为10∶1;
8)酒白芍:取净白芍片,用黄酒喷洒均匀,稍润后放锅内炒至微黄色,白芍与黄酒的重量比为10∶1;
9)蜜制瓜蒌皮:取炼蜜用适量开水稀释后,加入瓜蒌皮丝,拌匀,焖透,置锅内,用文火加热,炒至黄棕色不粘手为度;取出放凉,瓜蒌皮丝与炼蜜的重量比为4∶1;
10)米制蝼蛄:将锅以武火加热,撒米于锅底,俟起烟时,投入净蝼姑,缓缓翻动3-4遍,取出,拣取蝼蛄;净蝼蛄与米的重量比为3∶16;
11)煅制雷公藤:将雷公藤投入专用的锅内燃烧成炭,然后泼水,不使其化灰。待晒干后,用专用粉碎机研成粉;
12)米制蟋蟀:将锅以武火加热,撒米于锅底,俟起烟时,投入蟋蟀,缓缓翻动3-4遍后,取出,拣取蟋蟀;净蟋蟀与米的重量比为3∶16;
13)将其余的原料和制鳖甲以及煨木香、制乳香、制没药、酒延胡索、炒白术、酒白芍、蜜制瓜蒌皮、米制蝼蛄、煅制雷公藤、米制蟋蟀混合,用粉碎机粉碎,过120目筛成为细末;
14)将以上细末分袋密封包装,密封在瓷罐内,然后将瓷罐埋藏于土壤内,深0.5米,两年后取出烘干,备用;
15)取芸豆用粉碎机粉碎,过100目筛成为细末,加入60℃水浸泡120分钟并打捞豆皮、去除豆渣,静止60分钟后取含有植物凝集素的上清液,将上清液煮沸30分钟后放凉,再次煮沸,反复进行6次;
16)将药物细末与熬炼好的上清液及蜂蜜按1∶1∶1.5混匀,搓条、和丸得治疗胸腔积液的药物。
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101049484A (zh) * | 2007-05-14 | 2007-10-10 | 郝来勤 | 一种治疗肺癌及其它各种癌症的强效中药 |
CN102335374A (zh) * | 2011-10-09 | 2012-02-01 | 许俊斋 | 一种专治肺癌的药物 |
CN102949621A (zh) * | 2012-09-27 | 2013-03-06 | 邹平起 | 中药基因信息修复素及其制备方法 |
-
2014
- 2014-08-28 CN CN201410449854.8A patent/CN104258178A/zh active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101049484A (zh) * | 2007-05-14 | 2007-10-10 | 郝来勤 | 一种治疗肺癌及其它各种癌症的强效中药 |
CN102335374A (zh) * | 2011-10-09 | 2012-02-01 | 许俊斋 | 一种专治肺癌的药物 |
CN102949621A (zh) * | 2012-09-27 | 2013-03-06 | 邹平起 | 中药基因信息修复素及其制备方法 |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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CN104667088A (zh) * | 2015-01-26 | 2015-06-03 | 阮秀云 | 一种胸腔热灌注液的制备方法 |
CN104857346A (zh) * | 2015-05-31 | 2015-08-26 | *** | 一种用于治疗胸腔积液的中药 |
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CN107823552A (zh) * | 2017-11-03 | 2018-03-23 | 吉林大学 | 一种治疗恶性胸腔积液的药物组合物及其制备方法 |
CN113318205A (zh) * | 2021-06-15 | 2021-08-31 | 吉林省中医药科学院(吉林省中医药科学院第一临床医院) | 一种治疗胸腔积液、心包积液的中药组合物 |
CN113318205B (zh) * | 2021-06-15 | 2022-10-28 | 吉林省中医药科学院(吉林省中医药科学院第一临床医院) | 一种治疗胸腔积液、心包积液的中药组合物 |
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