CN107823552A - 一种治疗恶性胸腔积液的药物组合物及其制备方法 - Google Patents
一种治疗恶性胸腔积液的药物组合物及其制备方法 Download PDFInfo
- Publication number
- CN107823552A CN107823552A CN201711071397.3A CN201711071397A CN107823552A CN 107823552 A CN107823552 A CN 107823552A CN 201711071397 A CN201711071397 A CN 201711071397A CN 107823552 A CN107823552 A CN 107823552A
- Authority
- CN
- China
- Prior art keywords
- parts
- pharmaceutical composition
- seed
- pleural effusion
- malignant pleural
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/65—Amphibians, e.g. toads, frogs, salamanders or newts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明提供一种治疗恶性胸腔积液的药物组合物及其制备方法,涉及疾病治疗药物领域,由以下重量份数的原料制备而成:黄芪20‑40份、白术20‑40份、葶苈子15‑25份、干蟾皮15‑25份、冬凌草15‑25份、白毛藤5‑15份、白花蛇舌5‑15份、草瓜蒌10‑20份、杏仁8‑16份、大黄8‑16份、五加皮10‑18份、车前子5‑12份、莪术6‑12份、徐长卿7‑15份、党参5‑15份、半枝莲3‑9份、炙麻黄2‑10份、薏苡仁5‑12份、石见穿2‑8份、淫羊藿4‑10份,本发明具有治疗效果好,能有效减轻患者痛苦,制备方法简单的优点。
Description
技术领域
本发明涉及疾病治疗药物领域,具体涉及一种治疗恶性胸腔积液的药物组合物及其制备方法。
背景技术
胸腔积液为胸腔科临床常见症状之一,约有25%属于恶性胸膜渗液,主要来自于肺癌,其次为乳腺癌、恶性淋巴瘤、间皮瘤等,恶性胸腔积液的出现表明肿瘤已到晚期,所以在积极治疗原发肿瘤的同时,应对恶性胸腔积液采取积极有效的治疗;恶性肿瘤的胸膜转移或胸膜原发肿瘤所致的胸腔积液为恶性胸腔积液,恶性胸腔积液的形成通常由以下因素造成:(1)肿瘤并发胸膜转移使胸膜通透性增加;(2)肿瘤直接浸润和伴随的炎症使毛细血管通透性增加;(3)癌栓阻塞了血管和***,或合并纵膈***转移,使胸水的回流吸收受阻;(4)肿瘤引起的肺不张使胸腔内压进一步降低;(5)继发底单白血症等;恶性胸腔积液的局部治疗目的是要排除胸腔积液,缓解压迫症状,减轻病人痛苦,恢复原来肺功能,并试图直接杀灭癌细胞或胸腔产生无菌性炎症粘连,近年来胸腔内接入性药物层出不穷,但疗效各异,目前大多采用的方法是顺铂、榄香烯乳和力尔凡进行胸腔内注射治疗,顺铂作为一种广谱癌药物,因其疗效确切,价格便宜而广泛为基层医院使用,它不通过肝脏活化即可直接杀伤浆膜腔表面及积液内的癌细胞,故一直作为腔内化疗的首选药物之一,但其严重的消化道反应给患者带来一定的痛苦和心理负担,另外,它还有不同程度的骨髓抑制,常给下一步治疗的按时实施带来困难;榄香烯乳是从中药莪术中提取的有效抗癌药物,其有效成分榄香烯,能抑制肿瘤细胞生长和繁殖,且能直接作用于细胞膜,使肿瘤细胞破裂死亡,故用以治疗恶性浆膜腔积液具有较好疗效,但其常伴有发热、胸痛等不良反应;而力尔凡是从溶血性链球菌中提取的一种生物反应修饰剂,可直接杀死肿瘤细胞,调节患者机体对肿瘤细胞进行有效抑制和杀伤,但需与化疗、放疗、内分泌治疗合用,从而减轻毒副作用,改善患者免疫功能,控制恶性肿瘤的进展,且需要进行胸腔内灌注;基于上述原因,目前还没有一种行之有效的、副作用小、便于使用的用于治疗恶性胸腔积液的药物,迫切需要进行这方面的研究和探讨。
发明内容
(一)解决的技术问题
针对现有技术的不足,本发明提供了一种治疗恶性胸腔积液的药物组合物及其制备方法,具有治疗效果好,能有效减轻患者痛苦,制备方法简单的优点。
(二)技术方案
为实现以上目的,本发明通过以下技术方案予以实现:
一种治疗恶性胸腔积液的药物组合物,由以下重量份数的原料制备而成:黄芪20-40份、白术20-40份、葶苈子15-25份、干蟾皮15-25份、冬凌草15-25份、白毛藤5-15份、白花蛇舌5-15份、草瓜蒌10-20份、杏仁8-16份、大黄8-16份、五加皮10-18份、车前子5-12份、莪术6-12份、徐长卿7-15份、党参5-15份、半枝莲3-9份、炙麻黄2-10份、薏苡仁5-12份、石见穿2-8份、淫羊藿4-10份。
优选地,所述治疗恶性胸腔积液的药物组合物,由以下重量份数的原料制备而成:黄芪25-35份、白术25-35份、葶苈子18-22份、干蟾皮16-20份、冬凌草18-20份、白毛藤7-12份、白花蛇舌8-12份、草瓜蒌12-18份、杏仁10-13份、大黄10-13份、五加皮13-16份、车前子7-10份、莪术8-10份、徐长卿10-13份、党参7-11份、半枝莲5-7份、炙麻黄5-7份、薏苡仁7-10份、石见穿5-7份、淫羊藿6-8份。
上述治疗恶性胸腔积液的药物组合物的制备方法,包括以下步骤:
(1)按配方称取各原料;
(2)将黄芪、白术、干蟾皮、白毛藤、草瓜蒌、杏仁、大黄、半枝莲和炙麻黄分别粉碎、研磨、过筛得到药材粉末,将药材粉末混合后,加入到质量分数为40-70%的乙醇溶液,搅拌回流提取4-8h,趁热过滤,得到乙醇提取液;
(3)将葶苈子、冬凌草、五加皮、车前子、莪术、徐长卿、党参、薏苡仁、石见穿、淫羊藿粉碎后加入到去离子水中超声震荡30-50min再加热至70-90℃提取3-5h,一次压滤后,滤渣继续加入到去离子水中,80-100℃提取2-4h后,二次压滤,滤渣弃去,两次滤液合并后,减压浓缩得到粘稠膏状浓缩物,将乙醇提取液加入并搅拌升温溶清后减压浓缩成浸膏,喷雾干燥,得到所述药物组合物。
优选地,所述步骤(2)中药材粉末的粒径为0.05-0.2mm。
优选地,所述步骤(2)中药材粉末与所述乙醇溶液的重量比的1:20。
优选地,所述步骤(3)中超声震荡的功率为200-400W。
(三)有益效果
本发明提供了一种治疗恶性胸腔积液的药物组合物及其制备方法,具有以下有益效果:
(1)恶性胸腔积液在中医无此病名,属于中医“悬饮”、“支饮”范畴,病位在肺、脾、肾三脏,病性属于虚实夹杂,本发明各个组分配伍得当,具有宣泄肺中痰水,利水渗湿,化痰燥湿,益气健脾、祛瘀抗癌的功效,相比于传统的“十枣汤”,本发明不会耗损正气,服用后起效快,副作用小。
(2)制备方法简单,条件温和,对于不同特性的原料用不同溶剂分类进行提取,原料中有效成分提取率高,无效成分很少或基本不被提取,省去了后续分离纯化步骤,节省了生产成本,缩短了生产周期。
具体实施方式
为使本发明实施例的目的、技术方案和优点更加清楚,下面将结合本发明实施例,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
实施例1:
一种治疗恶性胸腔积液的药物组合物,其特征在于,黄芪25份、白术25份、葶苈子18份、干蟾皮16份、冬凌草18份、白毛藤7份、白花蛇舌8份、草瓜蒌12份、杏仁10份、大黄10份、五加皮13份、车前子7份、莪术8份、徐长卿10份、党参7份、半枝莲5份、炙麻黄5份、薏苡仁7份、石见穿5份、淫羊藿6份。
上述治疗恶性胸腔积液的药物组合物的制备方法,包括以下步骤:
(1)按配方称取各原料;
(2)将黄芪、白术、干蟾皮、白毛藤、草瓜蒌、杏仁、大黄、半枝莲和炙麻黄分别粉碎、研磨、过筛得到粒径为0.15mm的药材粉末,将药材粉末混合后,加入到质量分数为50%的乙醇溶液,药材粉末与乙醇溶液的重量比的1:20,搅拌回流提取6h,趁热过滤,得到乙醇提取液;
(3)将葶苈子、冬凌草、五加皮、车前子、莪术、徐长卿、党参、薏苡仁、石见穿、淫羊藿粉碎后加入到去离子水中超声震荡40min,超声震荡的功率为300W,再加热至80℃提取4h,一次压滤后,滤渣继续加入到去离子水中,90℃提取3h后,二次压滤,滤渣弃去,两次滤液合并后,减压浓缩得到粘稠膏状浓缩物,将乙醇提取液加入并搅拌升温溶清后减压浓缩成浸膏,喷雾干燥,得到所述药物组合物。
实施例2:
一种治疗恶性胸腔积液的药物组合物,其特征在于,黄芪35份、白术35份、葶苈子2份、干蟾皮20份、冬凌草20份、白毛藤12份、白花蛇舌12份、草瓜蒌18份、杏仁13份、大黄13份、五加皮16份、车前子10份、莪术10份、徐长卿13份、党参11份、半枝莲7份、炙麻黄7份、薏苡仁10份、石见穿7份、淫羊藿8份。
上述治疗恶性胸腔积液的药物组合物的制备方法,包括以下步骤:
(1)按配方称取各原料;
(2)将黄芪、白术、干蟾皮、白毛藤、草瓜蒌、杏仁、大黄、半枝莲和炙麻黄分别粉碎、研磨、过筛得到粒径为0.1mm的药材粉末,将药材粉末混合后,加入到质量分数为60%的乙醇溶液,药材粉末与乙醇溶液的重量比的1:20,搅拌回流提取7h,趁热过滤,得到乙醇提取液;
(3)将葶苈子、冬凌草、五加皮、车前子、莪术、徐长卿、党参、薏苡仁、石见穿、淫羊藿粉碎后加入到去离子水中超声震荡45min,超声震荡的功率为300W,再加热至80℃提取4h,一次压滤后,滤渣继续加入到去离子水中,90℃提取2h后,二次压滤,滤渣弃去,两次滤液合并后,减压浓缩得到粘稠膏状浓缩物,将乙醇提取液加入并搅拌升温溶清后减压浓缩成浸膏,喷雾干燥,得到所述药物组合物。
实施例3:
一种治疗恶性胸腔积液的药物组合物,其特征在于,黄芪20份、白术20份、葶苈子15份、干蟾皮15份、冬凌草15份、白毛藤5份、白花蛇舌5份、草瓜蒌10份、杏仁8份、大黄8份、五加皮10份、车前子5份、莪术6份、徐长卿7份、党参5份、半枝莲3份、炙麻黄2份、薏苡仁5份、石见穿2份、淫羊藿4份。
上述治疗恶性胸腔积液的药物组合物的制备方法,包括以下步骤:
(1)按配方称取各原料;
(2)将黄芪、白术、干蟾皮、白毛藤、草瓜蒌、杏仁、大黄、半枝莲和炙麻黄分别粉碎、研磨、过筛得到粒径为0.05mm的药材粉末,将药材粉末混合后,加入到质量分数为40%的乙醇溶液,药材粉末与乙醇溶液的重量比的1:20,搅拌回流提取4h,趁热过滤,得到乙醇提取液;
(3)将葶苈子、冬凌草、五加皮、车前子、莪术、徐长卿、党参、薏苡仁、石见穿、淫羊藿粉碎后加入到去离子水中超声震荡30min,超声震荡的功率为200W,再加热至70℃提取3h,一次压滤后,滤渣继续加入到去离子水中,80℃提取2h后,二次压滤,滤渣弃去,两次滤液合并后,减压浓缩得到粘稠膏状浓缩物,将乙醇提取液加入并搅拌升温溶清后减压浓缩成浸膏,喷雾干燥,得到所述药物组合物。
实施例4:
一种治疗恶性胸腔积液的药物组合物,其特征在于,黄芪40份、白术40份、葶苈子25份、干蟾皮25份、冬凌草25份、白毛藤15份、白花蛇舌15份、草瓜蒌20份、杏仁16份、大黄16份、五加皮18份、车前子12份、莪术12份、徐长卿15份、党参15份、半枝莲9份、炙麻黄10份、薏苡仁12份、石见穿8份、淫羊藿10份。
上述治疗恶性胸腔积液的药物组合物的制备方法,包括以下步骤:
(1)按配方称取各原料;
(2)将黄芪、白术、干蟾皮、白毛藤、草瓜蒌、杏仁、大黄、半枝莲和炙麻黄分别粉碎、研磨、过筛得到粒径为0.2mm的药材粉末,将药材粉末混合后,加入到质量分数为70%的乙醇溶液,药材粉末与乙醇溶液的重量比的1:20,搅拌回流提取8h,趁热过滤,得到乙醇提取液;
(3)将葶苈子、冬凌草、五加皮、车前子、莪术、徐长卿、党参、薏苡仁、石见穿、淫羊藿粉碎后加入到去离子水中超声震荡50min,超声震荡的功率为400W,再加热至90℃提取5h,一次压滤后,滤渣继续加入到去离子水中,100℃提取4h后,二次压滤,滤渣弃去,两次滤液合并后,减压浓缩得到粘稠膏状浓缩物,将乙醇提取液加入并搅拌升温溶清后减压浓缩成浸膏,喷雾干燥,得到所述药物组合物。
实施例5:
一种治疗恶性胸腔积液的药物组合物,其特征在于,黄芪25份、白术35份、葶苈子20份、干蟾皮20份、冬凌草20份、白毛藤10份、白花蛇舌10份、草瓜蒌15份、杏仁12份、大黄10份、五加皮16份、车前子7份、莪术8份、徐长卿10份、党参10份、半枝莲6份、炙麻黄5份、薏苡仁10份、石见穿6份、淫羊藿8份。
上述治疗恶性胸腔积液的药物组合物的制备方法,包括以下步骤:
(1)按配方称取各原料;
(2)将黄芪、白术、干蟾皮、白毛藤、草瓜蒌、杏仁、大黄、半枝莲和炙麻黄分别粉碎、研磨、过筛得到粒径为0.2mm的药材粉末,将药材粉末混合后,加入到质量分数为40%的乙醇溶液,药材粉末与乙醇溶液的重量比的1:20,搅拌回流提取8h,趁热过滤,得到乙醇提取液;
(3)将葶苈子、冬凌草、五加皮、车前子、莪术、徐长卿、党参、薏苡仁、石见穿、淫羊藿粉碎后加入到去离子水中超声震荡50min,超声震荡的功率为200W,再加热至90℃提取3h,一次压滤后,滤渣继续加入到去离子水中,80℃提取4h后,二次压滤,滤渣弃去,两次滤液合并后,减压浓缩得到粘稠膏状浓缩物,将乙醇提取液加入并搅拌升温溶清后减压浓缩成浸膏,喷雾干燥,得到所述药物组合物。
本发明药物组合物用于治疗恶性胸腔积液,2个月为1个疗程,治疗1-6个疗程,治疗80例,总有效率为87%,本发明具有显著的治疗效果,治愈率高。
需要说明的是,在本文中,诸如第一和第二等之类的关系术语仅仅用来将一个实体或者操作与另一个实体或操作区分开来,而不一定要求或者暗示这些实体或操作之间存在任何这种实际的关系或者顺序。而且,术语“包括”、“包含”或者其任何其他变体意在涵盖非排他性的包含,从而使得包括一系列要素的过程、方法、物品或者设备不仅包括那些要素,而且还包括没有明确列出的其他要素,或者是还包括为这种过程、方法、物品或者设备所固有的要素。在没有更多限制的情况下,由语句“包括一个……”限定的要素,并不排除在包括所述要素的过程、方法、物品或者设备中还存在另外的相同要素。
以上实施例仅用以说明本发明的技术方案,而非对其限制;尽管参照前述实施例对本发明进行了详细的说明,本领域的普通技术人员应当理解:其依然可以对前述各实施例所记载的技术方案进行修改,或者对其中部分技术特征进行等同替换;而这些修改或者替换,并不使相应技术方案的本质脱离本发明各实施例技术方案的精神和范围。
Claims (6)
1.一种治疗恶性胸腔积液的药物组合物,其特征在于,由以下重量份数的原料制备而成:黄芪20-40份、白术20-40份、葶苈子15-25份、干蟾皮15-25份、冬凌草15-25份、白毛藤5-15份、白花蛇舌5-15份、草瓜蒌10-20份、杏仁8-16份、大黄8-16份、五加皮10-18份、车前子5-12份、莪术6-12份、徐长卿7-15份、党参5-15份、半枝莲3-9份、炙麻黄2-10份、薏苡仁5-12份、石见穿2-8份、淫羊藿4-10份。
2.如权利要求1所述的治疗恶性胸腔积液的药物组合物,其特征在于,由以下重量份数的原料制备而成:黄芪25-35份、白术25-35份、葶苈子18-22份、干蟾皮16-20份、冬凌草18-20份、白毛藤7-12份、白花蛇舌8-12份、草瓜蒌12-18份、杏仁10-13份、大黄10-13份、五加皮13-16份、车前子7-10份、莪术8-10份、徐长卿10-13份、党参7-11份、半枝莲5-7份、炙麻黄5-7份、薏苡仁7-10份、石见穿5-7份、淫羊藿6-8份。
3.如权利要求1所述的治疗恶性胸腔积液的药物组合物的制备方法,其特征在于,包括以下步骤:
(1)按配方称取各原料;
(2)将黄芪、白术、干蟾皮、白毛藤、草瓜蒌、杏仁、大黄、半枝莲和炙麻黄分别粉碎、研磨、过筛得到药材粉末,将药材粉末混合后,加入到质量分数为40-70%的乙醇溶液,搅拌回流提取4-8h,趁热过滤,得到乙醇提取液;
(3)将葶苈子、冬凌草、五加皮、车前子、莪术、徐长卿、党参、薏苡仁、石见穿、淫羊藿粉碎后加入到去离子水中超声震荡30-50min,再加热至70-90℃提取3-5h,一次压滤后,滤渣继续加入到去离子水中,80-100℃提取2-4h后,二次压滤,滤渣弃去,两次滤液合并后,减压浓缩得到粘稠膏状浓缩物,将乙醇提取液加入并搅拌升温溶清后减压浓缩成浸膏,喷雾干燥,得到所述药物组合物。
4.如权利要求3所述的治疗恶性胸腔积液的药物组合物的制备方法,其特征在于,所述步骤(2)中药材粉末的粒径为0.05-0.2mm。
5.如权利要求3所述的治疗恶性胸腔积液的药物组合物的制备方法,其特征在于,所述步骤(2)中药材粉末与所述乙醇溶液的重量比的1:20。
6.如权利要求3所述的治疗恶性胸腔积液的药物组合物的制备方法,其特征在于,所述步骤(3)中超声震荡的功率为200-400W。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711071397.3A CN107823552A (zh) | 2017-11-03 | 2017-11-03 | 一种治疗恶性胸腔积液的药物组合物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711071397.3A CN107823552A (zh) | 2017-11-03 | 2017-11-03 | 一种治疗恶性胸腔积液的药物组合物及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN107823552A true CN107823552A (zh) | 2018-03-23 |
Family
ID=61653688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201711071397.3A Pending CN107823552A (zh) | 2017-11-03 | 2017-11-03 | 一种治疗恶性胸腔积液的药物组合物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN107823552A (zh) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6641846B2 (en) * | 2000-11-08 | 2003-11-04 | Tianjin Yanling Health Food Co. | Pharmaceutical composition against type I allergy and the preparation thereof |
CN104258178A (zh) * | 2014-08-28 | 2015-01-07 | 吕彦丽 | 一种治疗肺癌胸腔积液的药物及其制备方法 |
CN105267751A (zh) * | 2015-11-12 | 2016-01-27 | 青岛市市立医院 | 用于治疗气阴两虚型恶性胸腔积液的药物 |
-
2017
- 2017-11-03 CN CN201711071397.3A patent/CN107823552A/zh active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6641846B2 (en) * | 2000-11-08 | 2003-11-04 | Tianjin Yanling Health Food Co. | Pharmaceutical composition against type I allergy and the preparation thereof |
CN104258178A (zh) * | 2014-08-28 | 2015-01-07 | 吕彦丽 | 一种治疗肺癌胸腔积液的药物及其制备方法 |
CN105267751A (zh) * | 2015-11-12 | 2016-01-27 | 青岛市市立医院 | 用于治疗气阴两虚型恶性胸腔积液的药物 |
Non-Patent Citations (1)
Title |
---|
贺真: "己椒苈黄汤加味治疗胸腔积液15例", 《江西中医药》 * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN100528211C (zh) | 一种用于***的中药 | |
CN105031301A (zh) | 一种抗肿瘤中药组合物及其制备方法 | |
CN103316192B (zh) | 一种治疗腰腿痛的中药泡脚液及制备方法 | |
CN107823552A (zh) | 一种治疗恶性胸腔积液的药物组合物及其制备方法 | |
CN104524477A (zh) | 一种治疗结节性甲状腺肿的中药组合物 | |
CN105920296A (zh) | 用于气阴两虚型冠心病心绞痛辅助治疗的中药制剂及制备 | |
CN103341013A (zh) | 一种治疗腰腿痛的中药 | |
KR20170135416A (ko) | 중국 의약 조성물 및 그 제조 방법 | |
CN110638888A (zh) | 用于***的中药组合物 | |
CN1088796A (zh) | 治疗***的药及其制造方法 | |
CN1814153A (zh) | 一种预防和治疗乳腺癌的药物组合物及其制备方法 | |
CN108126154A (zh) | 一种治疗瘀血阻络痹症疼痛的纳米分散液的制备方法及应用 | |
CN111494508B (zh) | 一种中药痛风贴的制备方法及其产品 | |
CN106389824A (zh) | 一种通宣理肺的中药颗粒及其制备方法 | |
CN105770515A (zh) | 一种治疗***炎的中药组合物及其制备方法 | |
CN1063074C (zh) | 一种***的中药注射液及制造方法 | |
CN109224005A (zh) | 一种治疗肝癌中药组合物及其制备方法 | |
CN115400163A (zh) | 一种清肺养肺茶及其生产工艺 | |
CN106074912A (zh) | 一种治疗心脑血管疾病的中药制剂 | |
CN109820956A (zh) | 一种用于肿瘤化疗后滋补的中药组合物及其制备方法 | |
CN111803598A (zh) | 一种祛湿通络的中药制剂 | |
CN113456711A (zh) | 一种治疗皮肤病的彝药 | |
CN103893348A (zh) | 一种治疗放射性皮肤损伤的中药药膏及制备方法 | |
CN114931620A (zh) | 一种治疗腰腿疼头疼面部半瘫***无名肿瘤的药物 | |
CN111529622A (zh) | 一种益气养血化瘀药剂及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180323 |
|
RJ01 | Rejection of invention patent application after publication |