CN104237127B - Specimen holder and corresponding analyzer with TIP head placement mechanisms - Google Patents
Specimen holder and corresponding analyzer with TIP head placement mechanisms Download PDFInfo
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- CN104237127B CN104237127B CN201410466627.6A CN201410466627A CN104237127B CN 104237127 B CN104237127 B CN 104237127B CN 201410466627 A CN201410466627 A CN 201410466627A CN 104237127 B CN104237127 B CN 104237127B
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Abstract
The invention provides a kind of specimen holder with TIP head placement mechanisms, including：Specimen holder base, test tube placement rack, specimen holder handgrip, rotating shaft；Test tube placement rack is connected on specimen holder base by rotating shaft, and specimen holder handgrip is arranged on test tube placement rack；Test tube placement rack, including pedestal, also includes that the sample cell for being arranged at pedestal is placed cavity, TIP heads and places cavity.Present invention also offers corresponding robotics luminescence analyzer.The present invention have the test tube rate of loading fast, simple structure, easy to maintain the characteristics of, the analysis operating efficiency of robotics luminescence analyzer can be greatly improved.
Description
Technical field
The present invention relates to specimen holder, and in particular to specimen holder and corresponding analyzer with TIP head placement mechanisms, especially
A kind of specimen holder for Full-automatic chemiluminescence immunoassay analysis meter (in-vitro diagnosis equipment).
Background technology
Chemiluminescent analyzer be by detect patients serum so as to carry out the medical laboratory instrument of immunoassay to human body,
Quantitative patients serum and horseradish peroxidase (HRP) are added to solid-phase coating has in the White-opalescent microwell plate of antibody,
Testing molecule in serum is combined with the antibody specificity on the conjugate and solid phase carrier of horseradish peroxidase, separating, washing
Unreacted free composition, is subsequently adding luminous bottom liquid, and the free energy discharged using chemical reaction excites intermediate, returns from ground state
Excitation state is arrived, energy is discharged in the form of photon.
Chinese patent literature (application number " 201310718774.3 ", title " of the application publication number for CN103743916A
Plant Full-automatic chemiluminescence immunoassay analysis meter "), a kind of Full-automatic chemiluminescence immunoassay analysis meter is disclosed, the analyzer includes：
TIP tube modules, reaction tube module, sample tube module, reagent tube module, TIP pipe fetching devices, three-dimensional machinery arm module, wherein
Three-dimensional machinery arm module can drive TIP pipe fetching device arbitrary motions on working face, react the reaction tube in tube module
With TIP pipes come the product of being loaded and reagent adding, the reaction tube is picked and placeed and is moved by TIP pipes fetching device.
But, in place of analyzer Shortcomings disclosed in the patent document it is：
(1) specimen holder substantially 5-20 sample bit of strip, TIP individually placed, is not easy to sample cell and TIP heads
The quick fetching when quick load of (i.e. TIP pipes) and analysis；
(2) displacement structure of sample cell and TIP heads is not applied for the sample cell and TIP heads of different tube diameters；
(3) using photoelectric sensor test tubes restocking situation, complex structure, and easily damaged, detection is not accurate enough, and
Restocking situation can only qualitatively be detected, it is impossible to detect the information of reagent in test tube.
Content of the invention
For defect of the prior art, it is an object of the invention to provide a kind of specimen holder with TIP head placement mechanisms and
Corresponding analyzer.
According to the present invention provide a kind of specimen holder with TIP head placement mechanisms, including：Specimen holder base, test tube are placed
Seat, specimen holder handgrip, rotating shaft；Test tube placement rack is connected on specimen holder base by rotating shaft, and specimen holder handgrip is arranged on test tube
On placement rack；
Test tube placement rack, including pedestal, also includes that the sample cell for being arranged at pedestal is placed cavity, TIP heads and places cavity.
Preferably, multiple TIP heads place cavity, with the central shaft of rotating shaft as axially and with the circumference apart from r as radius
On, it is uniformly distributed circumferentially；
Multiple sample cells place cavity, with the central shaft of rotating shaft as, axially and with the circumference apart from R as radius, edge is all
To being uniformly distributed；
Wherein, it is more than apart from r apart from R.
Preferably, the quantity that TIP heads place cavity with sample cell places cavity is equal, and corresponds；
Wherein, the one-to-one corresponding, refers to：Corresponding TIP heads placement cavity is distributed in same with sample cell placement cavity
One medial and lateral in the radial direction.
Preferably, TIP heads place the upper end open opening's edge of the upper end open opening's edge higher than sample cell placement cavity of cavity.
Preferably, pedestal includes TIP disks, sample base；
The center of sample base is provided with TIP disk mounting grooves, and TIP disks are removably arranged on TIP disk mounting grooves
Interior；
TIP heads are placed cavity and are arranged at TIP disks, and sample cell is placed cavity and is arranged at sample base；
Upper surface of the upper surface of TIP disks higher than sample base.
Preferably, the enveloping surface of pedestal side is shaped as the side view of cylinder；
The sample cell is placed cavity and is made up of the cell body in pedestal, the cell body along the axially extending of pedestal, cell body
Notch is arranged on the side of pedestal, and the both ends open of cell body is located at upper surface, the lower surface of pedestal respectively；
Test tube clamping spring leaf is provided with the sample cell placed cavity body.
Preferably, also include that bar code installs buckle, wherein, bar code installs the side that buckle is arranged on pedestal.
Preferably, bar code installs the region between the notch of the adjacent cell body that buckle is arranged on pedestal.
Preferably, buckle and the draw-in groove being engaged is provided between TIP disks and sample base.
According to a kind of robotics luminescence analyzer that the present invention is provided, including the sample of above-mentioned band TIP head placement mechanisms
Product frame.
Compared with prior art, the present invention has following beneficial effect：
1. sample tube simple structure, easy to assembly；
The installation of 2.TIP heads is easier, time-consuming, improves efficiency.
1st, TIP heads are provided with specimen holder simultaneously and place cavity and sample cell placement cavity, be easy to robotics to light
Quick fetching of the analyzer to test tube, while also allow for quick load of the operating personnel to TIP heads；
2nd, spring leaf is provided with sample cell placed cavity body, the spring leaf causes sample cell to be located at sample cell and places cavity
Center axial position, and the sample cell of different tube diameters can be applied to；
3rd, buckle is installed using bar code, bar code can be installed so that robotics luminescence analyzer can be swept by bar code
Information in the bar code of imaging apparatus region, to obtain in each sample cell placed cavity body whether unloaded and each placement cavity pilot scale
The information of agent.
4th, TIP disks are detachably connected so that can pull down TIP disks when TIP is loaded, and load after finishing again by TIP disks
And TIP heads are integrally pacified back, easy to operate quick.
5th, the round-shaped and sample cell of pedestal places the circumference layout that cavity and TIP heads place cavity so that automatically
The movement travel of the mechanical arm of chemiluminescent analyzer is shortened dramatically, and by the rotation of pedestal, mechanical arm can be caused only to have
The mobility having in both direction, improves accuracy.
Description of the drawings
The detailed description that non-limiting example is made with reference to the following drawings by reading, the further feature of the present invention,
Objects and advantages will become more apparent upon：
Fig. 1 is that a kind of main view of specimen holder for Full-automatic chemiluminescence immunoassay analysis meter disclosed in this invention is illustrated
Figure；
Fig. 2 is that a kind of vertical view of specimen holder for Full-automatic chemiluminescence immunoassay analysis meter disclosed in this invention is illustrated
Figure；
Fig. 3 is the generalized section in the E-E directions in Fig. 2；
Fig. 4 is that a kind of stereochemical structure of the disclosed specimen holder for Full-automatic chemiluminescence immunoassay analysis meter of invention is shown
It is intended to.
In figure：
1- specimen holder bases
2- test tube placement racks
3- spring leafs
4- hex screws
5-TIP disks
6- specimen holder handgrips
7- bar code buckles
Specific embodiment
With reference to specific embodiment, the present invention is described in detail.Following examples will be helpful to the technology of this area
Personnel further understand the present invention, but the invention is not limited in any way.It should be pointed out that the ordinary skill to this area
For personnel, without departing from the inventive concept of the premise, some deformations and improvement can also be made.These belong to the present invention
Protection domain.
The invention provides a kind of robotics luminescence analyzer and its specimen holder with TIP head placement mechanisms, which passes through
Structure design to specimen holder so that the sample tube being put into is easier to fix, runs into short and small sample tube auxiliary without borrowing
Assistant engineer's tool is directly fixed, and TIP heads disposably all can be loaded, easy to operate.
Specifically, as shown in Figure 1, Figure 2, Figure 3 and Figure 4, the specimen holder with TIP head placement mechanisms, including：Specimen holder
Base, test tube placement rack, specimen holder handgrip, rotating shaft；Test tube placement rack is connected on specimen holder base by rotating shaft, and specimen holder is grabbed
Hand is arranged on test tube placement rack；Test tube placement rack, including pedestal, also includes that the sample cell for being arranged at pedestal places cavity, TIP
Head places cavity.Coaxial and axle can be rotated centered on rotating shaft relative between, sample between specimen holder base, test tube placement rack
Frame handgrip is used for analyzer or operating personnel lift specimen holder.
Multiple TIP heads place cavity, with the central shaft of rotating shaft as, axially and with the circumference apart from r as radius, edge is all
To being uniformly distributed；Multiple sample cells place cavitys, with the central shaft of rotating shaft as axially and with the circumference apart from R as radius,
It is uniformly distributed circumferentially；Wherein, it is more than apart from r apart from R.The quantity that TIP heads place cavity with sample cell places cavity is equal, and
Correspond；Wherein, the one-to-one corresponding, refers to：Corresponding TIP heads placement cavity is distributed in same with sample cell placement cavity
One medial and lateral in the radial direction.TIP heads place the upper end open that the upper end open opening's edge of cavity places cavity higher than sample cell
Opening's edge.
Described placement cavity can be open cylinder, and the cavity has 10, with the less roundlet of a diameter
It is evenly distributed in a bigger cylinder being made up of pedestal side enveloping surface；The open-ended cavity is on the outside of big cylinder
Opening, is had the position of stationary spring in the inner part, is easy to stationary spring, sample tube fixation to be fixed using spring leaf.So,
The pressure that sample tube can be produced by compression spring leaf when fixed will not make sample tube glide come fixed sample test tube,
So as to reach design requirement.
Further, pedestal includes TIP disks, sample base；The center of sample base is provided with TIP disk mounting grooves, TIP
Disk is removably arranged in TIP disk mounting grooves；TIP heads are placed cavity and are arranged at TIP disks, and sample cell is placed cavity and arranged
In sample base；Upper surface of the upper surface of TIP disks higher than sample base.So when TIP heads are loaded, can first by TIP
Disk is pulled down, and is then installed TIP first time property, is loaded without one by one, so as to time-consuming, improves efficiency.
More specifically, the enveloping surface of pedestal side is shaped as the side view of cylinder；The sample cell places cavity
It is made up of the cell body in pedestal, the cell body is arranged on the side of pedestal along the axially extending of pedestal, the notch of cell body, cell body
Both ends open is located at upper surface, the lower surface of pedestal respectively；Test tube clamping spring leaf is provided with the sample cell placed cavity body.
The specimen holder also includes that bar code installs buckle, and wherein, bar code installs the side that buckle is arranged on pedestal.Bar code is installed buckle and is set
Put the region between the notch of the adjacent cell body of pedestal.Preferably, the card being engaged is provided between TIP disks and sample base
Button and draw-in groove.
During the use of specimen holder of the present invention：
1. operating personnel have first marked the numbering of specimen holder, and TIP heads are put well, are put into sample tube, then specimen holder
It is positioned in the sample rotation dish of Full-automatic chemiluminescence immunoassay analysis meter, by the sample of Full-automatic chemiluminescence immunoassay analysis meter
Being automatically brought into operation for this rotation dish, completes the sample extraction of correlation, markers work.In this loading process, hence it is evident that than raw sample frame
Loading time shortens, and improves operating efficiency.
When sample tube is placed, sample tube is put into the acceptance of the bid of test tube placement rack to be had the corresponding hole site of sequence number (i.e. sample cell is put
Put cavity) place, relevant position is inserted into, sample cell when inserting sample tube, can be made to place the sample tube clamping in cavity
There is elastic deformation in spring leaf, so as to fixed sample test tube；When placing TIP heads, first the TIP disks without TIP heads can be taken out,
The TIP disks for filling TIP heads are pressed into original position as requested.
2. associated mechanisms of the sample of the mark by Full-automatic chemiluminescence immunoassay analysis meter, complete corresponding interpolation and try
Agent, incubation, cleaning, the process for adding a series of automatic chemiluminescence immunoassays such as excimer, DATA REASONING.
Above the specific embodiment of the present invention is described.It is to be appreciated that the invention is not limited in above-mentioned
Particular implementation, those skilled in the art can make various modifications or modification within the scope of the claims, this not shadow
Ring the flesh and blood of the present invention.
Claims (9)
1. a kind of specimen holder with TIP head placement mechanisms, including：Specimen holder base, test tube placement rack, specimen holder handgrip, rotating shaft；
Test tube placement rack is connected on specimen holder base by rotating shaft, and specimen holder handgrip is arranged on test tube placement rack；Test tube placement rack,
Including pedestal, also include that the sample cell for being arranged at pedestal is placed cavity, TIP heads and places cavity；
Pedestal includes TIP disks, sample base；
The center of sample base is provided with TIP disk mounting grooves, and TIP disks are removably arranged in TIP disk mounting grooves；
TIP heads are placed cavity and are arranged at TIP disks, and sample cell is placed cavity and is arranged at sample base；
Upper surface of the upper surface of TIP disks higher than sample base.
2. the specimen holder with TIP head placement mechanisms according to claim 1, it is characterised in that
Multiple TIP heads place cavitys, with the central shaft of rotating shaft as axially and with the circumference apart from r as radius, circumferentially
Even distribution；
Multiple sample cells place cavitys, with the central shaft of rotating shaft as axially and with the circumference apart from R as radius, circumferentially
Even distribution；
Wherein, it is more than apart from r apart from R.
3. the specimen holder with TIP head placement mechanisms according to claim 2, it is characterised in that TIP heads place cavity and sample
The quantity that QC places cavity is equal, and corresponds；
Wherein, the one-to-one corresponding, refers to：Corresponding TIP heads are placed cavity and are distributed in same footpath with sample cell placement cavity
To the medial and lateral on direction.
4. the specimen holder with TIP head placement mechanisms according to claim 2, it is characterised in that TIP heads place the upper of cavity
End opening opening's edge places the upper end open opening's edge of cavity higher than sample cell.
5. the specimen holder with TIP head placement mechanisms according to claim 1, it is characterised in that the enveloping surface of pedestal side
It is shaped as the side view of cylinder；
The sample cell is placed cavity and is made up of the cell body in pedestal, and the cell body is along the axially extending of pedestal, the notch of cell body
The side of pedestal is arranged on, the both ends open of cell body is located at upper surface, the lower surface of pedestal respectively；
Test tube clamping spring leaf is provided with the sample cell placed cavity body.
6. the specimen holder with TIP head placement mechanisms according to claim 5, it is characterised in that also include that bar code installs card
Button, wherein, bar code installs the side that buckle is arranged on pedestal.
7. the specimen holder with TIP head placement mechanisms according to claim 6, it is characterised in that bar code is installed buckle and arranged
Region between the notch of the adjacent cell body of pedestal.
8. the specimen holder with TIP head placement mechanisms according to claim 1, it is characterised in that TIP disks and sample base it
Between be provided with the buckle and draw-in groove being engaged.
9. a kind of robotics luminescence analyzer, it is characterised in that the robotics luminescence analyzer includes will according to right
Seek the specimen holder of the band TIP head placement mechanisms any one of 1 to 8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410466627.6A CN104237127B (en) | 2014-09-12 | 2014-09-12 | Specimen holder and corresponding analyzer with TIP head placement mechanisms |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410466627.6A CN104237127B (en) | 2014-09-12 | 2014-09-12 | Specimen holder and corresponding analyzer with TIP head placement mechanisms |
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| CN104237127A CN104237127A (en) | 2014-12-24 |
| CN104237127B true CN104237127B (en) | 2017-03-15 |
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| CN201410466627.6A Active CN104237127B (en) | 2014-09-12 | 2014-09-12 | Specimen holder and corresponding analyzer with TIP head placement mechanisms |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106290945B (en) * | 2015-05-18 | 2024-01-16 | 深圳迈瑞生物医疗电子股份有限公司 | Sample adapter, sample positioning device and batch sample analysis method |
| CN108267395A (en) * | 2018-04-13 | 2018-07-10 | 佛山市恩正生物医药科技有限公司 | A kind of stream type cell analyzer |
| CN110286119B (en) * | 2019-06-28 | 2024-04-19 | 武汉明德生物科技股份有限公司 | TIP head detection frame, sample type detection module assembly and chemiluminescence immunoassay analyzer |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3193443B2 (en) * | 1992-04-24 | 2001-07-30 | オリンパス光学工業株式会社 | Automatic analyzer |
| JP4851266B2 (en) * | 2006-06-30 | 2012-01-11 | シスメックス株式会社 | Sample analyzer |
| JP4975407B2 (en) * | 2006-10-10 | 2012-07-11 | シスメックス株式会社 | Analysis equipment |
| CN101865927A (en) * | 2009-04-17 | 2010-10-20 | 武汉医尔特科技有限公司 | Novel full-automatic blood type analyzer |
| CN101672842B (en) * | 2009-09-01 | 2013-01-02 | 郑州博赛生物技术股份有限公司 | Detection kit for fully automatic immunity analyzer |
| CN101782575B (en) * | 2010-02-10 | 2012-12-05 | 郑州博赛生物技术股份有限公司 | Inner ring and outer ring double flow line structure for fully-automatic immunity analyzer |
| CN201949892U (en) * | 2011-01-04 | 2011-08-31 | 宋勇林 | Test tube rack |
| CN102419375B (en) * | 2011-08-24 | 2013-08-28 | 四川迈克生物科技股份有限公司 | Full-automatic chemoluminescence immunoassay analyzer |
| CN204228724U (en) * | 2014-09-12 | 2015-03-25 | 苏州国科鼎翼生物科技有限公司 | Robotics luminescence analyzer and sample shelf apparatus thereof |
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Effective date of registration: 20190617 Address after: 450016 No. 28 First Avenue, Zhengzhou Economic and Technological Development Zone, Zhengzhou City, Henan Province Patentee after: ZHENGZHOU RENFU BIOCELL BIOTECHNOLOGY Co.,Ltd. Address before: 215000 No. 78 Keling Road, Suzhou High-tech Zone, Suzhou City, Jiangsu Province Patentee before: SUZHOU GUOKE DINGYI BIOLOGICAL TECHNOLOGY CO.,LTD. |
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Address after: 450016 No. 28 First Avenue, Zhengzhou Economic and Technological Development Zone, Zhengzhou City, Henan Province Patentee after: Zhengzhou Bosai Biotechnology Co.,Ltd. Address before: 450016 No. 28 First Avenue, Zhengzhou Economic and Technological Development Zone, Zhengzhou City, Henan Province Patentee before: ZHENGZHOU RENFU BIOCELL BIOTECHNOLOGY Co.,Ltd. Address after: 450016 No. 28 First Avenue, Zhengzhou Economic and Technological Development Zone, Zhengzhou City, Henan Province Patentee after: Zhengzhou Biocell Biotechnology Co.,Ltd. Address before: 450016 No. 28 First Avenue, Zhengzhou Economic and Technological Development Zone, Zhengzhou City, Henan Province Patentee before: Zhengzhou Bosai Biotechnology Co.,Ltd. |
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