CN101865927A - Novel full-automatic blood type analyzer - Google Patents
Novel full-automatic blood type analyzer Download PDFInfo
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- CN101865927A CN101865927A CN200910061665A CN200910061665A CN101865927A CN 101865927 A CN101865927 A CN 101865927A CN 200910061665 A CN200910061665 A CN 200910061665A CN 200910061665 A CN200910061665 A CN 200910061665A CN 101865927 A CN101865927 A CN 101865927A
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Abstract
The invention provides a novel full-automatic blood type analyzer, which comprises a sample disk subsystem, a reagent sampling subsystem, a reagent distribution subsystem, a reaction disk subsystem, a blowing mixing subsystem, a digital image recording and analyzing subsystem, a reaction cup cleaning subsystem, a computer control subsystem and a software management system, wherein the subsystems are arranged on an analyzer main frame and can perform automatic sample acquisition, and blood type analysis, recording and management respectively; the sample disk subsystem, the reagent sampling subsystem, the reagent distribution subsystem, the reaction disk subsystem, the blowing mixing subsystem, the digital image recording and analyzing subsystem and the reaction cup cleaning subsystem are connected with the computer control subsystem respectively; and a software management system and a digital image recording and analyzing program are stored in a master control computer of the computer control subsystem. The novel full-automatic blood type analyzer has the characteristics of high degree of automation, high detection speed, stable performance, high analysis accuracy, low cost and application to medical establishment.
Description
Technical field
The invention belongs to technical field of medical instruments, specifically be used for a kind of novel full-automatic blood type analyzer of health system.
Background technology
At present, clinical blood group analytical approach mainly is to finish by manual operation.This traditional method is to add sample and reagent by manual, and the naked eyes judged result, when workload is bigger, will make mistakes easily and confusion, and speed is very slow.Two full-automatic blood type analytical instrument device is abroad also arranged now, and it is used gradient plate and makes carrier based on a cover sample application of sample distribution system, carries out the digital imagery analysis again, and this method cost is higher, and is consuming time long, and the instrument price is high.Domestic semi-automatic blood group instrument needs to cooperate the sample adding system of import could realize full automatic working.China has bought full-automatic blood type analytical instrument except the big Blood Center of several families, and all the other all are blank.
Summary of the invention
The purpose of this invention is to provide that a kind of operating rate is fast, stable performance, analysis precision height, novel full-automatic blood type analyzer that cost is low.
Novel full-automatic blood type analyzer provided by the present invention, comprise casing and be located at instrument body frame in the casing, it is characterized in that: described analyser comprise be located on the instrument body frame can carry out respectively that sample is gathered automatically, sample disc subsystem, reagent application of sample subsystem, reagent assignment subsystem, reaction plate system, blowing mixing subsystem, digitized video record analysis subsystem, the reaction cup of blood group analysis, record and management clean subsystem, computer control subsystem and software management system; The sample disc subsystem is installed on the mounting bracket of fixedlying connected with the instrument body frame with the reaction plate system, reagent application of sample subsystem and reagent assignment subsystem are located between sample disc subsystem and the reaction plate system, blowing mixing subsystem is located at the top of reaction plate system by mounting bracket, digitized video record analysis subsystem is located at the top of reaction plate system by mounting bracket, reaction cup is cleaned the subsystem bottom and is installed on the instrument body frame, cleaning needle is in the reaction cup top on the reaction tray, the computer control subsystem is located in the switch board, described sample disc subsystem, reagent application of sample subsystem, the reagent assignment subsystem, the reaction plate system, blowing mixing subsystem, digitized video record analysis subsystem, reaction cup is cleaned subsystem and is connected with the computer control subsystem respectively, and software management system and digitized video recording analysing program are stored in the main control computer of computer control subsystem.
Described sample disc subsystem comprises sample hose, sample disc, barcode scanner, the sample disc motor, the sample disc handle, sample disc outer race tube position, sample disc inner ring pipe position, synchronizing wheel, the sample disc belt, positioning disk, sample disc rotating shaft axle sleeve, described sample disc motor, barcode scanner and sample disc rotating shaft axle sleeve are fixedlyed connected with the instrument body frame respectively, synchronizing wheel, positioning disk is fixedlyed connected with the rotation axis in the sample disc rotating shaft axle sleeve respectively, sample disc is connected with the rotation axis upper end, the rotating shaft of sample disc motor is by the sample disc belt, synchronizing wheel and sample disc are rotationally connected, be respectively equipped with the sample disc outer ring of 36 sample pore positions, inner ring pipe position is located on the sample disc circumference, barcode scanner is located at the sample disc periphery, its sweep signal is connected with computing machine, a plurality of sample hoses are located at the sample disc outer ring, inner ring Guan Weizhong, the sample hose outside is provided with the bar code information labeling.
Described reaction plate system comprises reaction tray, reaction cup, reaction tray optocoupler steady arm, reaction tray rotating shaft axle sleeve, the reaction tray gear, the reaction tray belt, the reaction tray motor, the reaction tray pallet, the rotating shaft shaft end ring, the rotating shaft disc, the rotating shaft main shaft, the reaction tray support, described reaction tray rotating shaft axle sleeve is fixedlyed connected with apparatus subject, the reaction tray support is fixedlyed connected with reaction tray rotating shaft axle sleeve, the rotating shaft main shaft is located in the reaction tray rotating shaft axle sleeve and with it and is rotationally connected, the one end is fixedlyed connected with the rotating shaft shaft end ring, the other end is fixedlyed connected with the reaction tray gear, the rotating shaft disc is fixedlyed connected with the reaction tray pallet, can place 12 reaction cup in the reaction tray pallet, be provided with position, six holes in the reaction cup, each 5 ° of the Kong Weiwei that rotate of reaction tray motor, two reaction tray optocoupler steady arms are oppositely arranged on the reaction tray tray bottom surface respectively and fixedly connected with it, and the signal output part of reaction tray optocoupler steady arm is connected with the reaction tray controller of computer control system.
Described reagent application of sample subsystem comprises sample needle, the feed head support, the support main shaft, the support off-axis, first, second, the 3rd application of sample motor, first, the second application of sample belt, the application of sample gear, application of sample rotating shaft axle sleeve, the rotating shaft disc, synchronous head, support main shaft slide block, conduit, slide block, fixed mount, the syringe main shaft, piston, screw pair mechanism, contiguous block, syringe, the sample needle of hollow structure is fixedlyed connected with the feed head support in described the moving up and down, support main shaft one end is fixedlyed connected with the feed head support, the other end is fixedlyed connected with support main shaft slide block, support main shaft slide block is fixedlyed connected with the second application of sample belt, be transition fit with the support off-axis simultaneously, can be slidingly connected with the support off-axis, the support off-axis is fixedlyed connected with support, support is fixedlyed connected with the rotating shaft disc, application of sample rotating shaft axle sleeve is fixedlyed connected with the instrument body frame, fixedly connected with the rotating shaft disc with an end of the rotating shaft of mating in the application of sample rotating shaft axle sleeve, the other end is fixedlyed connected with the application of sample gear, the first application of sample motor is dynamically connected by the first application of sample belt and application of sample gear rotation, the application of sample gear also is rotationally connected with support and sample needle, the second application of sample motor and the second application of sample belt and support main shaft slide block are in transmission connection, the syringe main shaft, syringe and the 3rd application of sample motor are fixedlyed connected with fixed mount, one end of contiguous block is fixedlyed connected with the main shaft of the 3rd application of sample motor, the other end is fixedlyed connected with screw pair mechanism, screw pair mechanism can be rotationally connected with the syringe main shaft, and with can go up, the slide block that moves is fixedly connected down, slipper piston is fixedly connected, piston outlet and sample needle inlet UNICOM, the 3rd application of sample motor can be rotationally connected with screw pair mechanism.
Described reagent assignment subsystem comprises reagent bottle, the reagent storehouse, peristaltic pump reagent ingress pipe, reaction cup, reagent adds model, reagent application of sample syringe needle, peristaltic pump reagent delivery line, reagent divides gas-distributing motor, peristaltic pump, fan, be provided with six reagent bottles that fill different reagent in the described reagent storehouse, reagent adds model and is provided with two the reagent application of sample positions, syringe needle hole and the first air-out pore position, be provided with three reagent sample needles in each position, reagent application of sample syringe needle hole, the two ends of peristaltic pump ingress pipe are communicated with reagent bottle and peristaltic pump input end respectively, the two ends of peristaltic pump delivery line are communicated with wriggling delivery side of pump and reagent application of sample syringe needle respectively, and be communicated with reaction cup by reagent, bottom, reagent storehouse is equipped with cooling piece and fan.
Described blowing mixing subsystem comprises first, the second vacuum pump line, the mixing vacuum pump, reaction cup, first, discharge pipe is stirred in second blowing, reagent adds plate, described mixing vacuum pump is installed on the apparatus subject, first, second blowing is stirred discharge pipe and is arranged on the reaction tray top, first blowing is stirred discharge pipe and is installed on the reagent interpolation plate, second blowing is stirred discharge pipe and is installed on the apparatus subject by support, first, one end of the second vacuum pump line all is communicated with mixing vacuum pump air outlet, their other ends are respectively with first, the air intake that discharge pipe is stirred in second blowing is communicated with first, the outlet air end homocline of the second blowing stirring discharge pipe is to reaction cup and be close to its inwall rim of a cup.
Described reaction cup is cleaned subsystem and is comprised washer bottle, reagent rack, waste liquid bottle, first, second cleans vacuum pump, cleaning needle, waste pipe, wash wrench, the clear water pipe, wash the wrench fastener, spring, reaction cup, reagent rack moving up and down is provided with the synchronous head with reagent application of sample subsystem same principle structure, support main shaft slide block, motor, driving belt, washing the wrench fastener fixedlys connected with cleaning needle, the cleaning needle afterbody can be slidingly connected with it in washing the wrench cavity, being provided with two pipes in the cleaning needle is communicated with waste pipe and purge pipe respectively, cleaning fluid in the washer bottle passes through purge pipe, second cleans in vacuum pump and cleaning needle and the reaction cup and is communicated with, and second cleans vacuum pump passes through the interior waste pipe of cleaning needle and is communicated with waste liquid bottle.
Described computer control subsystem comprises main control computer, single-chip microcomputer, interface circuit, Switching Power Supply, it is characterized in that: the output control terminal mouth of the single-chip microcomputer of described control system links to each other with the control end of sample disc controller, reaction tray controller, application of sample controller, reagent peristaltic pump controller, system controller, cleaning controller respectively, and the PORT COM of single-chip microcomputer links to each other with the data port of main control computer according to communications protocol through communication interface; The output terminal of sample disc controller is connected with the control end of sample disc motor; The output terminal of reaction tray controller is connected with the control end of reaction tray motor, the output terminal of application of sample controller is connected with the control end of first, second, third motor respectively, the output terminal of reagent peristaltic pump controller divides the control end of gas-distributing motor and fan to be connected with reagent respectively, the output terminal of system controller respectively with air blowing mixing vacuum pump and CCD camera control end be connected, the output terminal of cleaning controller respectively with first, second vacuum pump control end be connected; One FPDP of described single-chip microcomputer is connected by the output terminal of load module with optocoupler, detecting liquid level unit; Another group control port of single-chip microcomputer is connected with circuit protection unit through output module.
The present invention is to the sample disc subsystem by computer control system and software management system, reagent application of sample subsystem, the reagent assignment subsystem, the reaction plate system, blowing mixing subsystem, digitized video record analysis subsystem, reaction cup is cleaned numerous topworkies of subsystem, under the requirement of its complex time sequence, adopt and distribute sample and reagent automatically, unique cyclone mixing, high Definition CCD camera imaging record, analyze and be stored in computer, steps such as multistep cleaning realize a plurality of samples, reaction and measuring in the time of a plurality of project, realize the analytical work of full-automatic circulation blood group.
Automaticity height of the present invention, detection speed are fast, stable performance, analysis precision height, cost are low, are applicable to medical institutions.
Description of drawings
Fig. 1 is structural representation Fig. 1 of the present invention,
Fig. 2 is structural representation Fig. 2 of the present invention,
Fig. 3 is the sample disc structural representation,
Fig. 4 is the reaction tray vertical view,
Fig. 5 is the backplan of Fig. 4,
Fig. 6 is Fig. 4 A-A face cut-open view,
Fig. 7 is a reagent application of sample subsystem structure synoptic diagram,
Fig. 8 is a reagent assignment subsystem structural representation,
Fig. 9 is a blowing mixing subsystem structure synoptic diagram,
Figure 10 is that reaction cup is cleaned the subsystem structure synoptic diagram,
Figure 11 is the control circuit theory diagram,
Figure 12 is the computer control process flow diagram.
Among the figure: 1-sample hose, 2-sample disc, 3-barcode scanner; 4-sample disc motor, 5-rinse bath, the 6-first application of sample motor; the 7-second application of sample motor, 8-reagent storehouse, 9-fan; the 10-peristaltic pump; the 11-syringe pump, 12-mixing vacuum pump, 13-vacuum pump line; the 13-1-first vacuum pump line; the 13-2-second vacuum pump line, 14-reaction tray motor, 15-reaction tray; air outlet is stirred in 16-second blowing; the 17-CCD camera, 18-waste liquid bottle, 19-cleaning needle; 20-washes wrench; the 21-washer bottle, air outlet, 23-reagent application of sample syringe needle are stirred in 22-first blowing; the 24-sample needle; the 25-sample arm, 26-reagent adds model, the 27-reaction cup; the 28-reagent bottle; 29-sample disc handle, 30-sample disc outer race tube position, 31-sample disc inner ring pipe position; the 32-synchronizing wheel; 33-sample disc belt, 34-positioning disk, 35-sample disc rotation axis axle sleeve; 36-reaction tray optocoupler steady arm; 37-reaction tray rotating shaft axle sleeve, 38-reaction tray gear, 39-reaction tray belt; 40-reaction tray support; 41-reaction tray pallet, 42-rotating shaft shaft end ring, 43-rotating shaft disc; 44-rotating shaft main shaft; the 45-support, 46-feed head support, 47-support main shaft; 48-support off-axis; the 49-first application of sample belt, 50-application of sample gear, 51-application of sample rotating shaft axle sleeve; 52-rotating shaft disc; the 53-synchronous head, 54-support main shaft slide block, the 55-second application of sample belt; the 56-conduit; the 57-slide block, 58-fixed mount, 59-syringe main shaft; the 60-piston; 61-screw pair mechanism, 62-contiguous block, 63-syringe; 64-the 3rd application of sample motor; 65-reagent divides gas-distributing motor, 66-peristaltic pump reagent ingress pipe, 67-peristaltic pump reagent delivery line; 68-washes the wrench fastener; 69-second cleans vacuum pump, the 70-reagent rack, and 71-first cleans vacuum pump; the 72-waste pipe; 73-clear water pipe, 74-spring, 75-main control computer; the 76-single-chip microcomputer; 77-sample disc controller, 78-reaction tray controller, 79-application of sample controller; 80-reagent peristaltic pump controller; the 81-system controller, 82-cleaning controller, 83-communication interface; the 84-optocoupler; the detecting liquid level unit; the 85-load module, 86-output module, 87-circuit protection unit; the 88-Switching Power Supply; the 89-switch board, 90-instrument body frame, 91-mounting bracket.
Embodiment
The invention will be further described below in conjunction with accompanying drawing.Among Fig. 1,2, described analyser comprise be located on the instrument body frame can carry out respectively that sample is gathered automatically, sample disc subsystem, reagent application of sample subsystem, reagent assignment subsystem, reaction plate system, blowing mixing subsystem, digitized video record analysis subsystem, the reaction cup of blood group analysis, record and management clean subsystem, computer control subsystem and software management system; The sample disc subsystem is installed on the mounting bracket 91 of fixedlying connected with instrument body frame 90 with the reaction plate system, reagent application of sample subsystem and reagent assignment subsystem are located between sample disc subsystem and the reaction plate system, blowing mixing subsystem is located at the top of reaction plate system by mounting bracket 91, digitized video record analysis subsystem is located at the top of reaction plate system by mounting bracket 91, reaction cup is cleaned the subsystem bottom and is installed on the instrument body frame 90, cleaning needle 19 is in the reaction cup top on the reaction tray 15, the computer control subsystem is located in the switch board 89, described sample disc subsystem, reagent application of sample subsystem, the reagent assignment subsystem, the reaction plate system, blowing mixing subsystem, digitized video record analysis subsystem, reaction cup is cleaned subsystem and is connected with the computer control subsystem respectively, and software management system and digitized video recording analysing program are stored in the main control computer of computer control subsystem.
Among Fig. 3, described sample disc subsystem comprises sample hose 1, sample disc 2, barcode scanner 3, sample disc motor 4, sample disc handle 29, sample disc outer race tube position 30, sample disc inner ring pipe position 31, synchronizing wheel 32, sample disc belt 33, positioning disk 34, sample disc rotation axis axle sleeve 35, described sample disc motor 4, barcode scanner 3 and sample disc rotating shaft axle sleeve 35 are fixedlyed connected with the instrument body frame respectively, synchronizing wheel 32, positioning disk 34 is fixedlyed connected with the rotation axis in the sample disc rotating shaft axle sleeve 35 respectively, sample disc 2 is connected with the rotation axis upper end, the rotating shaft of sample disc motor 4 is by sample disc belt 33, synchronizing wheel 32 is rotationally connected with sample disc 2, be respectively equipped with the sample disc outer ring of 36 sample pore positions, inner ring pipe position 30,31 are located on sample disc 2 circumference, barcode scanner 3 is located at sample disc 2 periphery, its sweep signal is connected with computing machine, a plurality of sample hoses 1 are located at the sample disc outer ring, inner ring pipe position 30, in 31, sample hose 1 outside is provided with the bar code information labeling.
Fig. 4,5, in 6, described reaction plate system comprises reaction tray 15, reaction cup 27, reaction tray optocoupler steady arm 36, reaction tray rotating shaft axle sleeve 37, reaction tray gear 38, reaction tray belt 39, reaction tray motor 14, reaction tray pallet 41, rotating shaft shaft end ring 42, rotating shaft disc 43, rotating shaft main shaft 44, reaction tray support 40, described reaction tray rotating shaft axle sleeve 37 is fixedlyed connected with apparatus subject, reaction tray support 40 is fixedlyed connected with reaction tray rotating shaft axle sleeve, rotating shaft main shaft 44 is located in the reaction tray rotating shaft axle sleeve 37 and with it and is rotationally connected, the one end is fixedlyed connected with rotating shaft shaft end ring 42, the other end is fixedlyed connected with reaction tray gear 38, rotating shaft disc 43 is fixedlyed connected with reaction tray pallet 41, can place 12 reaction cup 27 in the reaction tray pallet 41, be provided with position, six holes in the reaction cup 27, reaction tray motor 14 each 5 ° of Kong Weiwei that rotate, two reaction tray optocoupler steady arms 36 are oppositely arranged on reaction tray pallet 41 bottom surfaces respectively and fixedly connected with it, and the signal output part of reaction tray optocoupler steady arm 36 is connected with the reaction tray controller 79 of computer control system.
Among Fig. 7, described reagent application of sample subsystem comprises sample needle 24, feed head support 46, support main shaft 47, support off-axis 48, first, second, the 3rd application of sample motor 6,7,64, first, the second application of sample belt 49,55, application of sample gear 50, application of sample rotating shaft axle sleeve 51, rotating shaft disc 52, synchronous head 53, support main shaft slide block 54, conduit 56, slide block 57, fixed mount 58, syringe main shaft 59, piston 60, screw pair mechanism 61, contiguous block 62, syringe 63, the sample needle 24 of hollow structure is fixedlyed connected with feed head support 46 in described the moving up and down, support main shaft 47 1 ends are fixedlyed connected with feed head support 46, the other end is fixedlyed connected with support main shaft slide block 54, support main shaft slide block 54 is fixedlyed connected with the second application of sample belt 55, be transition fit with support off-axis 48 simultaneously, can be slidingly connected with support off-axis 48, support off-axis 48 is fixedlyed connected with support 45, support 45 is fixedlyed connected with rotating shaft disc 52, application of sample rotating shaft axle sleeve 51 is fixedlyed connected with the instrument body frame, fixedly connected with rotating shaft disc 52 with an end of the rotating shaft of coupling in the application of sample rotating shaft axle sleeve 51, the other end is fixedlyed connected with application of sample gear 50, the first application of sample motor 6 is rotationally connected with application of sample gear 50 by the first application of sample belt 49, application of sample gear 50 also is rotationally connected with support 45 and sample needle 24, the second application of sample motor 7 and the second application of sample belt 55 and support main shaft slide block 54 are in transmission connection, syringe main shaft 59, syringe 63 and the 3rd application of sample motor 64 are fixedlyed connected with fixed mount 58, one end of contiguous block 62 is fixedlyed connected with the main shaft of the 3rd application of sample motor 64, the other end is fixedlyed connected with screw pair mechanism 61, screw pair mechanism 61 can be rotationally connected with syringe main shaft 59, and with can go up, the slide block 57 that moves is fixedly connected down, slide block 57 pistons 60 are fixedly connected, piston 60 outlets and sample needle 24 inlet UNICOMs, the 3rd application of sample motor 64 can be rotationally connected with screw pair mechanism 61.
Among Fig. 8, described reagent assignment subsystem comprises reagent bottle 28, reagent storehouse 8, peristaltic pump reagent ingress pipe 66, reaction cup 27, reagent adds model 26, reagent application of sample syringe needle 23, peristaltic pump reagent delivery line 67, reagent divides gas-distributing motor 65, peristaltic pump 10, fan 9, be provided with six reagent bottles 28 that fill different reagent in the described reagent storehouse 8, reagent adds model 26 and is provided with two reagent application of sample syringe needle positions, 23 hole and position, first discharge pipe, 22 hole, be provided with three reagent sample needles in each position, reagent application of sample syringe needle hole, the two ends of peristaltic pump ingress pipe 66 are communicated with reagent bottle 28 and peristaltic pump 10 input ends respectively, the two ends of peristaltic pump delivery line 67 are communicated with the output terminal and the reagent application of sample syringe needle 23 of peristaltic pump 10 respectively, and be communicated with reaction cup 27 by reagent, 8 bottoms, reagent storehouse are equipped with cooling piece and fan 9.
Among Fig. 9, described blowing mixing subsystem comprises first, the second vacuum pump line 13-1,13-2, mixing vacuum pump 12, reaction cup 27, first, discharge pipe 22 is stirred in second blowing, 16, reagent adds plate 26, described mixing vacuum pump 12 is installed on the apparatus subject, first, discharge pipe 22 is stirred in second blowing, 16 are arranged on reaction tray 15 tops, first blowing is stirred discharge pipe 22 and is installed on the reagent interpolation plate 26, second blowing is stirred discharge pipe 16 and is installed on the apparatus subject by support, first, the second vacuum pump line 13-1, the end of 13-2 all is communicated with mixing vacuum pump 12 air outlets, their other ends are respectively with first, discharge pipe 22 is stirred in second blowing, 16 air intake is communicated with, and first, discharge pipe 22 is stirred in second blowing, 16 outlet air end homocline is to reaction cup 27 and be close to its inwall rim of a cup.
Among Figure 10, described reaction cup is cleaned subsystem and is comprised washer bottle 21, reagent rack 70, waste liquid bottle 18, first, second cleans vacuum pump 71,69, cleaning needle 19, waste pipe 72, wash wrench 20, clear water pipe 73, wash wrench fastener 68, spring 74, reaction cup 27, reagent rack 70 moving up and down is provided with the synchronous head with reagent application of sample subsystem same principle structure, support main shaft slide block, motor, driving belt, washing wrench fastener 68 fixedlys connected with cleaning needle 19, cleaning needle 19 afterbodys can be slidingly connected with it in washing wrench 20 cavitys, being provided with two pipes in the cleaning needle 19 is communicated with waste pipe 72 and purge pipe 73 respectively, cleaning fluid in the washer bottle 21 is by purge pipe 73, second cleans vacuum pump 69 and cleaning needle 19 and 27 interior connections of reaction cup, and second cleans vacuum pump 71 is communicated with waste liquid bottle 18 by waste pipes in the cleaning needle 19.
Among Figure 11,12, described computer control subsystem comprises main control computer 75, single-chip microcomputer, interface circuit, Switching Power Supply 88, it is characterized in that: the output control terminal mouth of the single-chip microcomputer 76 of described control system links to each other with the control end of sample disc controller 77, reaction tray controller 78, application of sample controller 79, reagent peristaltic pump controller 80, system controller 81, cleaning controller 82 respectively, and the PORT COM of single-chip microcomputer 76 links to each other according to the data port of communications protocol with main control computer 75 through communication interface 83; The output terminal of sample disc controller 77 is connected with the control end of sample disc motor; The output terminal of reaction tray controller 78 is connected with the control end of reaction tray motor, the output terminal of application of sample controller 79 is connected with the control end of first, second, third motor respectively, the output terminal of reagent peristaltic pump controller 80 divides the control end of gas-distributing motor and fan to be connected with reagent respectively, the output terminal of system controller 81 respectively with air blowing mixing vacuum pump and CCD camera control end be connected, the output terminal of cleaning controller 82 respectively with first, second vacuum pump control end be connected; One FPDP of described single-chip microcomputer 76 is connected with the output terminal of optocoupler, detecting liquid level unit 84 by load module 85; Another group control port of single-chip microcomputer 76 is connected with circuit protection unit 87 through output module 86.
The method that is used for control of the present invention is by main control computer 75,76 pairs of described analyzers enforcement controls of single-chip microcomputer, to it is characterized in that:
The first step, after blood sample injected sample cell 1, sticks bar code, puts into sample disc 2, motor one 4 runnings drove sample disc 2 by belt and rotate, and sample disc 2 is each rotates a sample cell position. In the rotation process, barcode scanner 3 carries out bar code scan to each blood sample;
Second step, motor 26 drives sample arm 25 and rotates, in the time of directly over sample needle 24 turns to sample cell 1, motor 26 stops operating, and motor 37 rotates, and by belt sample needle 24 is descended, sample needle 24 is deep in the sample cell 1, syringe pump 11 work draw blood samples;
The 3rd step, motor 37 rotation drive sample needles 24 rise to highest point to be stopped, motor 26 rotates and drives sample arm 25 rotations, sample arm 25 turns to reaction tray 15 tops and stops operating, motor 37 rotates sample needle 24 is descended, sample needle 24 descends, and syringe pump 11 work are injected into blood sample in the reaction cup 27;
In the 4th step, motor 37 drives sample needles 24 and rises to peak, and motor 26 rotates and makes sample arm 25 turn to the rinse bath top, and sample needle 24 drops in the groove and cleans then;
In the 5th step, motor 4 14 drives reaction tray 15 and clockwise rotates, and makes the reaction cup of injecting blood sample be in reagent and adds under the model 26;
In the 6th step, driven by motor peristaltic pump 10 rotates, and the reagent that will be arranged in the reagent bottle 28 of agent bin 8 flow to reagent and adds reagent application of sample syringe needle 23 on the model 26, and reagent is injected reaction cup 27;
The 7th step, the Kong Weihou that motor 4 14 drives a reaction cup of reaction tray 15 rotations stops, vavuum pump 12 is started working, air-flow is transmitted to discharge pipe 2 22 by vacuum pump line 13, discharge pipe 2 22 is aimed at the reaction cup blowing that has added reagent, make reagent mix even, reaction tray 15 is rotated, and 2 22 pairs of next reagent of discharge pipe carry out mixing;
In the 8th step, reaction tray 15 turns to discharge pipe one 16 places, and vavuum pump 12 still in work, makes reagent mix more even, and reaction tray 15 is rotated a reaction cup position again and stopped then;
In the 9th step, 17 pairs in CCD camera reaction reagent is analyzed, and the result is filmed and remains in the computer, and according to its result of software analysis, camera scanning result and barcode scanner 3 scanning results is mapped, thereby obtain final detection result;
The tenth step, reaction tray 15 turns to washes under the wrench 20, driven by motor is washed wrench 20 and is dropped in the reaction cup, cleaning fluid in the washer bottle is injected in the reaction cup by cleaning needle (19), reaction cup is cleaned, again by cleaning needle with the waste water sucking-off, and waste water is stored in the waste liquid bottle 18;
The 11 step, motor 4 14 work, reaction cup is rotated, and carries out next round and detect.
Claims (9)
1. novel full-automatic blood type analyzer, comprise casing and be located at instrument body frame in the casing, it is characterized in that: described analyser comprise be located on the instrument body frame can carry out respectively that sample is gathered automatically, sample disc subsystem, reagent application of sample subsystem, reagent assignment subsystem, reaction plate system, blowing mixing subsystem, digitized video record analysis subsystem, the reaction cup of blood group analysis, record and management clean subsystem, computer control subsystem and software management system; The sample disc subsystem is installed on the mounting bracket (91) of fixedlying connected with instrument body frame (90) with the reaction plate system, reagent application of sample subsystem and reagent assignment subsystem are located between sample disc subsystem and the reaction plate system, blowing mixing subsystem is located at the top of reaction plate system by mounting bracket (91), digitized video record analysis subsystem is located at the top of reaction plate system by mounting bracket (91), reaction cup is cleaned the subsystem bottom and is installed on the instrument body frame (90), cleaning needle (19) is in the reaction cup top on the reaction tray (15), and the computer control subsystem is located in the switch board (89); Described sample disc subsystem, reagent application of sample subsystem, reagent assignment subsystem, reaction plate system, blowing mixing subsystem, digitized video record analysis subsystem, reaction cup are cleaned subsystem and are connected with the computer control subsystem respectively, and software management system and digitized video recording analysing program are stored in the main control computer of computer control subsystem.
2. full-automatic blood type analytical instrument according to claim 1 is characterized in that: described sample disc subsystem comprises sample hose (1), sample disc (2), barcode scanner (3), sample disc motor (4), sample disc handle (29), sample disc outer race tube position (30), sample disc inner ring pipe position (31), synchronizing wheel (32), sample disc belt (33), positioning disk (34), sample disc rotating shaft axle sleeve (35); Described sample disc motor (4), barcode scanner (3) and rotation axis axle sleeve (35) are fixedlyed connected with the instrument body frame respectively, synchronizing wheel (32), positioning disk (34) is fixedlyed connected with the rotation axis in the sample disc rotating shaft axle sleeve (35) respectively, sample disc (2) is connected with the rotation axis upper end, the rotating shaft of sample disc motor (4) is by sample disc belt (33), synchronizing wheel (32) is rotationally connected with sample disc (2), be respectively equipped with the sample disc outer ring of 36 sample pore positions, inner ring pipe position (30,31) be located on sample disc (2) circumference, barcode scanner (3) is located at sample disc (2) periphery, its sweep signal is connected with computing machine, a plurality of sample hoses (1) are located at the sample disc outer ring, inner ring pipe position (30,31) in, sample hose (1) outside is provided with the bar code information labeling.
3. full-automatic blood type analytical instrument according to claim 1 is characterized in that: described reaction plate system comprises reaction tray (15), reaction cup (27), reaction tray optocoupler steady arm (36), reaction tray rotating shaft axle sleeve (37), reaction tray gear (38), reaction tray belt (39), reaction tray motor (14), reaction tray pallet (41), rotating shaft shaft end ring (42), rotating shaft disc (43), rotating shaft main shaft (44), reaction tray support (40); Described reaction tray rotating shaft axle sleeve (37) is fixedlyed connected with apparatus subject, reaction tray support (40) is fixedlyed connected with reaction tray rotating shaft axle sleeve, rotating shaft main shaft (44) is located in the reaction tray rotating shaft axle sleeve (37) and with it and is rotationally connected, the one end is fixedlyed connected with rotating shaft shaft end ring (42), the other end is fixedlyed connected with reaction tray gear (38), rotating shaft disc (43) is fixedlyed connected with reaction tray pallet (41), can place 12 reaction cup (27) in the reaction tray pallet (41), be provided with position, six holes in the reaction cup (27), reaction tray motor (14) rotates 5 ° of Kong Weiwei at every turn, two reaction tray optocoupler steady arms (36) are oppositely arranged on reaction tray pallet (41) bottom surface respectively and fixedly connected with it, and the signal output part of reaction tray optocoupler steady arm (36) is connected with the reaction tray controller (79) of computer control system.
4. full-automatic blood type analytical instrument according to claim 1 is characterized in that: described reagent application of sample subsystem comprises sample needle (24), feed head support (46), support main shaft (47), support off-axis (48), first, second, the 3rd application of sample motor (6,7,64), first, the second application of sample belt (49,55), application of sample gear (50), application of sample rotating shaft axle sleeve (51), rotating shaft disc (52), synchronous head (53), support main shaft slide block (54), conduit (56), slide block (57), fixed mount (58), syringe main shaft (59), piston (60), screw pair mechanism (61), contiguous block (62), syringe (63); The sample needle (24) of hollow structure is fixedlyed connected with feed head support (46) in described the moving up and down, support main shaft (47) one ends are fixedlyed connected with feed head support (46), the other end is fixedlyed connected with support main shaft slide block (54), support main shaft slide block (54) is fixedlyed connected with the second application of sample belt (55), be transition fit with support off-axis (48) simultaneously, can be slidingly connected with support off-axis (48), support off-axis (48) is fixedlyed connected with support (45), support (45) is fixedlyed connected with rotating shaft disc (52), application of sample rotating shaft axle sleeve (51) is fixedlyed connected with the instrument body frame, fixedly connected with rotating shaft disc (52) with an end of the rotating shaft of coupling in the application of sample rotating shaft axle sleeve (51), the other end is fixedlyed connected with application of sample gear (50), the first application of sample motor (6) is rotationally connected by the first application of sample belt (49) and application of sample gear (50), application of sample gear (50) also is rotationally connected with support (45) and sample needle (24), the second application of sample motor (7) is in transmission connection with the second application of sample belt (55) and support main shaft slide block (54), syringe main shaft (59), syringe (63) and the 3rd application of sample motor (64) are fixedlyed connected with fixed mount (58), one end of contiguous block (62) is fixedlyed connected with the main shaft of the 3rd application of sample motor (64), the other end is fixedlyed connected with screw pair mechanism (61), screw pair mechanism (61) can be rotationally connected with syringe main shaft (59), and with can go up, the slide block (57) that moves is fixedly connected down, slide block (57) is fixedlyed connected with piston (60), piston (60) outlet and sample needle (24) inlet UNICOM, the 3rd application of sample motor (64) can be rotationally connected with screw pair mechanism (61).
5. full-automatic blood type analytical instrument according to claim 1 is characterized in that: described reagent assignment subsystem comprises that reagent bottle (28), reagent storehouse (8), peristaltic pump reagent ingress pipe (66), reaction cup (27), reagent add model (26), reagent application of sample syringe needle (23), peristaltic pump reagent delivery line (67), reagent and divides gas-distributing motor (65), peristaltic pump (10), fan (9); Be provided with six reagent bottles (28) that fill different reagent in the described reagent storehouse (8), reagent adds model (26) and is provided with two reagent application of sample syringe needles (23) position, hole and first discharge pipe (22) position, hole, be provided with three reagent sample needles in each position, reagent application of sample syringe needle hole, the two ends of peristaltic pump ingress pipe (66) are communicated with reagent bottle (28) and peristaltic pump (10) input end respectively, the two ends of peristaltic pump delivery line (67) are communicated with the output terminal and the reagent application of sample syringe needle (23) of peristaltic pump (10) respectively, and be communicated with reaction cup (27) by reagent, reagent storehouse (8) bottom is equipped with cooling piece and fan (9).
6. full-automatic blood type analytical instrument according to claim 1 is characterized in that: described blowing mixing subsystem comprises that discharge pipe (22,16) is stirred in first, second vacuum pump line (13-1,13-2), mixing vacuum pump (12), reaction cup (27), first, second blowing, reagent adds plate (26); Described mixing vacuum pump (12) is installed on the apparatus subject, first, discharge pipe (22 is stirred in second blowing, 16) be arranged on reaction tray (15) top, first blowing is stirred discharge pipe (22) and is installed on the reagent interpolation plate (26), second blowing is stirred discharge pipe (16) and is installed on the apparatus subject by support, first, the second vacuum pump line (13-1, end 13-2) all is communicated with mixing vacuum pump (12) air outlet, their other ends are respectively with first, discharge pipe (22 is stirred in second blowing, 16) air intake is communicated with, and first, discharge pipe (22 is stirred in second blowing, 16) outlet air end homocline is to reaction cup (27) and be close to its inwall rim of a cup.
7. full-automatic blood type analytical instrument according to claim 1 is characterized in that: described reaction cup cleans that subsystem comprises washer bottle (21), reagent rack (70), waste liquid bottle (18), first, second cleans vacuum pump (71,69), cleaning needle (19), waste pipe (72), washes wrench (20), clear water pipe (73), washes wrench fastener (68), spring (74), reaction cup (27); Reagent rack moving up and down (70) is provided with the synchronous head with reagent application of sample subsystem same principle structure, support main shaft slide block, motor, driving belt, washing wrench fastener (68) fixedlys connected with cleaning needle (19), cleaning needle (19) afterbody can be slidingly connected with it in washing wrench (20) cavity, being provided with two pipes in the cleaning needle (19) is communicated with waste pipe (72) and purge pipe (73) respectively, cleaning fluid in the washer bottle (21) is by purge pipe (73), second cleans in vacuum pump (69) and cleaning needle (19) and the reaction cup (27) and is communicated with, and the second cleaning vacuum pump (71) passes through the interior waste pipe of cleaning needle (19) and is communicated with waste liquid bottle (18).
8. full-automatic blood type analytical instrument according to claim 1, it is characterized in that: described computer control subsystem comprises main control computer (75), single-chip microcomputer, interface circuit, Switching Power Supply (88), it is characterized in that: the output control terminal mouth of the single-chip microcomputer of described control system (76) respectively with sample disc controller (77), reaction tray controller (78), application of sample controller (79), reagent peristaltic pump controller (80), system controller (81), the control end of cleaning controller (82) links to each other, and the PORT COM of single-chip microcomputer (76) links to each other according to the data port of communications protocol with main control computer (75) through communication interface (83); The output terminal of sample disc controller (77) is connected with the control end of sample disc motor; The output terminal of reaction tray controller (78) is connected with the control end of reaction tray motor, the output terminal of application of sample controller (79) is connected with the control end of first, second, third motor respectively, the output terminal of reagent peristaltic pump controller (80) divides the control end of gas-distributing motor and fan to be connected with reagent respectively, the output terminal of system controller (81) respectively with air blowing mixing vacuum pump and CCD camera control end be connected, the output terminal of cleaning controller (82) respectively with first, second vacuum pump control end be connected; One FPDP of described single-chip microcomputer (76) is connected with the output terminal of optocoupler, detecting liquid level unit (84) by load module (85); Another group control port of single-chip microcomputer (76) is connected with circuit protection unit (87) through output module (86).
9. a method that is used for novel full-automatic blood type analyzer is implemented control by main control computer (75), single-chip microcomputer (76) to described analyser, it is characterized in that:
The first step when blood sample injects sample hose (1), sticks bar code, is put into after the sample disc (2), and sample disc motor (4) running drives sample disc (2) by belt and rotates, and sample disc (2) is rotated a sample hose position at every turn; In the rotation process, barcode scanner (3) carries out bar code scan to each blood sample;
Second step, the first application of sample motor (6) drives sample arm (25) and rotates, in the time of directly over sample needle (24) turns to sample hose (1), the first application of sample motor (6) stops operating, the second application of sample motor (7) rotates, by belt sample needle (24) is descended, sample needle (24) is deep in the sample hose (1), syringe pump (11) work draw blood sample;
The 3rd step, the second application of sample motor (7) rotation drive sample needle (24) rises to highest point to be stopped, the first application of sample motor (6) rotates and drives sample arm (25) rotation, sample arm (25) turns to reaction tray (15) top and stops operating, the second application of sample motor (7) rotates sample needle (24) is descended, sample needle (24) descends, and syringe pump (11) work is injected into blood sample in the reaction cup (27);
In the 4th step, the second application of sample motor (7) drives sample needle (24) and rises to peak, and the first application of sample motor (6) rotates and makes sample arm (25) turn to the rinse bath top, and sample needle (24) drops in the groove and cleans then;
In the 5th step, reaction tray motor (14) drives reaction tray (15) and clockwise rotates, and makes the reaction cup of injecting blood sample be in reagent and adds under the model (26);
In the 6th step, driven by motor peristaltic pump (10) rotates, and the reagent that will be arranged in the reagent bottle (28) of reagent storehouse (8) flow to reagent and adds reagent application of sample syringe needle (23) on the model (26), and reagent is injected reaction cup (27);
The 7th step, the Kong Weihou that reaction tray motor (14) drives a reaction cup of reaction tray (15) rotation stops, mixing vacuum pump (12) is started working, air communication is crossed the first vacuum pump line (13-1) and is transmitted to the first blowing stirring air outlet (22), first blowing is stirred air outlet (22) and is aimed at reaction cup (27) blowing that has added reagent, make reagent mix even, reaction tray (15) is rotated, and first blowing is stirred air outlet (22) next reagent is carried out mixing;
In the 8th step, reaction tray (15) turns to second blowing and stirs air outlet (16) and locate, and mixing vacuum pump (12) still in work, makes reagent mix more even by the second vacuum pump line (13-2), and reaction tray (15) is rotated a reaction cup position again and stopped then;
In the 9th step, CCD camera (17) is analyzed reaction reagent, the result is filmed and remains in the computer, and according to its result of software analysis, camera scanning result and barcode scanner (3) scanning result is mapped, thereby obtains final detection result;
The tenth step, reaction tray (15) turns to washes under the wrench (20), driven by motor is washed wrench (20) and is dropped in the reaction cup, cleaning fluid in the washer bottle is injected in the reaction cup by cleaning needle (19), reaction cup (27) is cleaned, again by cleaning needle with the waste water sucking-off, and waste water is stored in the waste liquid bottle (18);
The 11 step, reaction tray motor (14) work, reaction cup is rotated, and carries out next round and detect.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910061665A CN101865927A (en) | 2009-04-17 | 2009-04-17 | Novel full-automatic blood type analyzer |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910061665A CN101865927A (en) | 2009-04-17 | 2009-04-17 | Novel full-automatic blood type analyzer |
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| CN108593942A (en) * | 2018-04-17 | 2018-09-28 | 杭州电子科技大学 | A kind of cross matching method |
| CN109060987A (en) * | 2018-08-28 | 2018-12-21 | 兰州大学 | Seed integrated treatment unit before dogstail kind band endogenetic fungus microscopy |
| CN109444450A (en) * | 2018-12-27 | 2019-03-08 | 厦门先明生物技术有限公司 | A kind of whole blood sample automatic sampling apparatus |
| CN109444450B (en) * | 2018-12-27 | 2022-05-17 | 厦门先明生物技术有限公司 | Whole blood sample autoinjection device |
| CN114313942A (en) * | 2022-01-05 | 2022-04-12 | 方运和 | Whole-course sealed reagent reaction box capable of realizing secondary injection for rapid biological detection |
| CN114910657A (en) * | 2022-07-15 | 2022-08-16 | 山东第一医科大学第一附属医院(山东省千佛山医院) | Anal secretion detection device |
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Application publication date: 20101020 |