CN104225399A

CN104225399A - Traditional Chinese medicine for treating pulmonary tuberculosis

Info

Publication number: CN104225399A
Application number: CN201410448100.0A
Authority: CN
Inventors: 胡健
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-09-05
Filing date: 2014-09-05
Publication date: 2014-12-24

Abstract

The invention relates to a traditional Chinese medicine for treating pulmonary tuberculosis. The traditional Chinese medicine is prepared from the following raw herbal materials in parts by weight: 10 parts of radix stemonae, 5 parts of rhizoma bletillae, 10 parts of radix peucedani, 15 parts of humulus, 6 parts of radix gentianae macrophyllae and 10 parts of cortex lycii radicis. Proved by clinical experiments, the traditional Chinese medicine is capable of safely and effectively treating the pulmonary tuberculosis.

Description

A kind of Chinese medicine being used for the treatment of pulmonary tuberculosis

Technical field

The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicine being used for the treatment of pulmonary tuberculosis.

Background technology

Tuberculosis is the chronic infectious disease caused by mycobacterium tuberculosis infection.Tulase may invade the various organ of Whole Body, but mainly invades lungs, is called pulmonary tuberculosis.Excreter is its important source of infection.Not necessarily fall ill after human infection tulase, when resistance reduces or cell-mediated allergy increases, just may cause clinical onset.Clinical manifestation is have closer tuberculosis contact history, and onset can suddenly can be delayed, and mostly is low grade fever (afternoon for work), night sweat, weak, poor appetite, becomes thin, female menstrual disorder etc.; Respiratory symptom has cough, expectoration, spitting of blood, chest pain, in various degree uncomfortable in chest or dyspnea.

Pulmonary tuberculosis is the incidental a kind of chronic and deferred infectious disease of adolescence.Can fall ill throughout the year, the teenager of 15 years old to 35 years old is age peak year occurred frequently of pulmonary tuberculosis.4 ~ 8 weeks incubation periods.Wherein 80% occur in pulmonary, other positions (neck lymph, meninges, peritoneum, intestinal, skin, skeleton) also can secondary infection.Interpersonal respiratory infectious is the major way of this disease transmission.The source of infection is the consumptive of contact discharge of bacteria.Along with the propagation of environmental pollution and acquired immune deficiency syndrome (AIDS), incidence of tuberculosis is strong all the more.

The pathogenic bacterium tulase of pulmonary tuberculosis belongs to Actinomycetal, easily forms fastbacteria, forms certain difficulty to antibiotic therapy.Current western medicine has isoniazid, rifampicin, ethambutol, pyrazinamide, streptomycin etc., but its therapeutic effect is all undesirable and side effect is larger.

Primary disease belongs to the traditional Chinese medical science " consumptive disease ", " pulmonary tuberculosis " category according to its clinical manifestation.

Medical material present Research involved in the present invention is as follows:

The Radix Stemonae [source] this product is the root of Stemonaceae plant Radix Stemonae, Radix stemonae japonicae and radix stemonae tuberosae.After winter, overground part was withered or before rudiment in spring, lifted root, removing radicula, earth, in boiling water firm well-done time, take out and dry or dry.[nature and flavor] are sweet, bitter, tepor.[return through] returns lung meridian.[function cures mainly] nourishing the lung to arrest cough, parasite killing delousing.Main new chronic cough is coughed, pulmonary tuberculosis, pertussis; Enterobiasis, body louse, tinea scabies.[usage and dosage] 3 ~ 10g.[attention] taste have hot person to be cautious use of.

Pseudobulbus Bletillae (Rhizoma Bletillae) [source] this product is the rhizome of orchid Pseudobulbus Bletillae (Rhizoma Bletillae).Excavating the 9-10 month after plantation 3-4, about about 1h during rhizome is soaked, clean earth, except a fibrous root, take out without during the white heart to inner face through steaming and decocting, shine or a heatable brick bed to surface stiff non-caked time, with after sulfur smoked 1 night, to dry or a heatable brick bed is done, then hit residual palpus, surface is made to become bright and clean yellowish white, sieve decontamination.[nature and flavor] are bitter, sweet, puckery, cold.[return through] attaches to the lung and stomach meridians.[function cures mainly] astringing to arrest bleeding, detumescence and promoting granulation.Main spitting of blood, spit blood, epistaxis, has blood in stool, traumatic hemorrhage; Carbuncle pyogenic infections from tumour or sore; Scald and burn, rhagadia manus et pedis, anal fissure.[usage and dosage] 3 ~ 10g.

Radix Peucedani [source] this product is the root of samphire Peucedanum praeruptorum DUNN and RADIX PEUCEDANI.Autumn, winter take root, and the removing aerial stem of plant and earth, dry.[nature and flavor] are bitter, pungent, are slightly cold.[return through] returns lung, spleen, Liver Channel.[function cures mainly] dispelling wind and heat pathogens, lowering the adverse-rising QI to resolve phlegm.Main affection due to external wind and heat, lung-heat phlegm stagnancy; Cough with asthma abundant expectoration, expectorant Huang is sticky; Inverse lack of appetite, chest and diaphragm is full vexed.[usage and dosage] 5 ~ 10g.

Herba humuli scandentis [source] this product is the herb of moraceae plants Herba humuli scandentis.9 ~ October gathers in the crops, and selects fine day, harvesting aerial parts, and removing impurity, dries.[nature and flavor] are sweet, bitter, cold.[return through] returns lung, kidney channel.[function cures mainly] heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome.Main cough due to lung-heat, lung abscess; Deficiency-heat excessive thirst, pyretic stranguria, edema, dysuria, damp-heat dysentery; Pathopyretic ulcer, skin pruritus.[usage and dosage] 10 ~ 15g.

Radix Gentianae Macrophyllae [source] this product is the root of gentianaceae plant Radix Gentianae Macrophyllae, gentiana crassicaulis Duthie, gentiana straminea, Da Wuli Radix Gentianae Macrophyllae.After uprooting autumn, directly dry.[nature and flavor] are bitter, pungent, are slightly cold.[return through] returns stomach, liver, gallbladder meridian.[function cures mainly] wind-damp dispelling, relaxing muscles and tendons network, clearind deficient heat, dampness removing jaundice eliminating.The logical pain of main air arthralgia chiefly caused by damp pathogen, muscles and bones contracture, hands and feet caused by paralysis; Osteopyrexia and fever, children's's infantile malnutrition with fever, jaundice due to damp-heat.[usage and dosage] 5 ~ 10g.

Cortex Lycii [source] this product is the root bark of matrimony vine of solanaceae plant.Early spring, late fall excavate root, clean earth, strip skin zone, dry.[nature and flavor] are sweet, cold.[return through] returns lung, kidney channel.[function cures mainly] clearind deficient heat, purte the white, removing heat from blood.Main hectic fever due to deficiency of YIN, hectic fever due to YIN-deficiency night sweat; Infantile malnutrition generates heat, dyspnea and cough due to lung-heat; Spit blood, epistaxis, hematuria; Quench one's thirst.[usage and dosage] 9 ~ 15g.

Summary of the invention

The present invention aims to provide a kind of Chinese medicine being used for the treatment of pulmonary tuberculosis, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing pulmonary tuberculosis.

In order to achieve the above object, the present invention is by the following technical solutions:

Be used for the treatment of a Chinese medicine for pulmonary tuberculosis, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: the Radix Stemonae 10 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, Radix Peucedani 10 parts, Herba humuli scandentis 15 parts, Radix Gentianae Macrophyllae 6 parts, Cortex Lycii 10 parts.

Inventor thinks that the pulmonary tuberculosis cause of disease is nothing more than endexoteric two aspects, and exopathogenic factor infects, and endogenous cause of ill is QI and blood deficiency, cloudy essence consume.Because healthy energy is first hindered, body void is not multiple, then consumptive disease worm is taken advantage of a weak point in opponent's defence and invades, and consumptive disease worm-eaten lung, lack of lung-YIN, injury of blood vessel of the lung by heat is then shown in the diseases such as dry cough, spitting of blood, parched throat.The deficiency of the lung can not transporation of body fluid, and kidney loses the source of money life, then disease and in kidney, deficiency of kidney yin, asthenic fire disturbance, then see osteopyrexia and fever, man's nocturnal emission, woman's amenorrhea, very then kidney-YIN being deficient, hyperactivity of hesrt-fire and liver-fire, on walk what lung, more to the bright lung yin that disappears, then see that night sweat is insomnia, irritated susceptible to get angry, the diseases such as pain in chest and hypochondrium.The deficiency of the lung consumes the autotrophy of taking mother-qi by force again, then sick and in spleen, deficiency of the spleen causing weakness of QI, and sees and breathe hard, the diseases such as weak, anorexia, loose stool.In a word, primary disease begins mostly to be consumption of YIN-fluid, and disease is lung, and continue then hyperactivity of fire caused by deficiency of YIN, and lung kidney is with sick or deficiency of both QI and YIN, and lung spleen is with sick.Treatment should support lung with YIN nourishing, replenishing QI to invigorate the spleen, enrich and benefit essence and blood, resolving heat and reducing pathogenic fire, relieving cough and resolving phlegm are basic, therefore assembly is our.

Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:

1, physical data

Inventor in October, 2010 ~ 2013 collect outpatient service and Mycobacterium tuberculosis in hospitalized tuberculosis patient 89 example altogether between year June, be divided into treatment group 45 example and matched group 44 example at random, treatment group man 33 example, female 22 example, 43 ~ 81 years old age, 46 years old mean age, the course of disease 1 ~ 3 year; Matched group man 28 example, female 16 example, 40 ~ 80 years old age, 48 years old mean age, the course of disease 1 ~ 3 year.2 groups of sexes, age and course of disease comparing difference not statistically significants, have comparability.

Diagnostic criteria

Diagnostic criteria according to diagnosis of pulmonary tuberculosis and treatment guidelines: 1) to cough, expectoration three weeks or more, can with symptoms such as spitting of blood, chest pain, dyspnea; 2) generate heat (Chang Wuhou low grade fever), night sweat can be accompanied, weak, appetite reduces, lose weight, menoxenia; 3) allergic manifestation that causes of tuberculosis allergy: erythema nodosum, phlyctenular conjunctivitis and tuberculosis rheumatism etc.; 4) tuberculin (PPD C5TU) tuerculoderma: represent that when presenting strong positive body is in super allergic state, morbidity risk rate is high, can be lungy with reference to indication as clinical diagnosis; 5), during hectic, physical signs of lung is often not obvious; Corresponding sign can be had, audible and middle fine bubbling rale when having obvious cavity or a concurrent bronchiectasis when pulmonary lesion is more extensive; Kang Nixia reduces prompting apex pulmonis pathological changes.

2, test method

2.1 Therapeutic Method

The decoct that the oral the present invention for the treatment of group obtains according to specific embodiment 1, every day 3 times.8 weeks courses for the treatment of.

The oral isoniazid tablets of matched group, takes according to its description.8 weeks courses for the treatment of.

3, criterion of therapeutical effect and therapeutic outcome

3.1 criterion of therapeutical effect

Cure: lung and bone tuberculosis imaging examination point out pathological tissues shade to absorb or calcification, pulmonary tuberculosis Sputum inspection (-), tuberculous meningitis and tuberculosis of intestine blood test point out erythrocyte sedimentation rate, TB-Ab changes into normally, hepatic lesion patient, liver function check is normal, patient clinical transference cure, body constitution is recovered;

Effective: patient clinical symptom makes moderate progress, appetite increases, and without night sweat hectic fever, body constitution takes a turn for the better;

Invalid: through treatment patient clinical symptom without improvement.

3.2 therapeutic outcomes are in table 1.

Table 1 liang group comparitive study

Group	n	Recovery from illness	Effective	Invalid	Total effective rate (%)	Serious adverse reaction example
							Treatment group	45	26	12	7	84.4%	0
Matched group	44	23	10	11	75.0%	0

Visible, the medicine that the present invention obtains can safe and effective treatment pulmonary tuberculosis, has promotional value.

Detailed description of the invention

In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.

Specific embodiment 1

Take: the Radix Stemonae 10 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 5 grams, Radix Peucedani 10 grams, Herba humuli scandentis 15 grams, Radix Gentianae Macrophyllae 6 grams, Cortex Lycii 10 grams; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.

Be used for the treatment of pulmonary tuberculosis.Oral, every bu morning, noon and afternoon take for three times.

Specific embodiment 2

Take: the Radix Stemonae 10 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 5 grams, Radix Peucedani 10 grams, Herba humuli scandentis 15 grams, Radix Gentianae Macrophyllae 6 grams, Cortex Lycii 10 grams; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.

Be used for the treatment of pulmonary tuberculosis.Oral, daily once.

Specific embodiment 3

Take: the Radix Stemonae 10 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 5 grams, Radix Peucedani 10 grams, Herba humuli scandentis 15 grams, Radix Gentianae Macrophyllae 6 grams, Cortex Lycii 10 grams; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.

Be used for the treatment of pulmonary tuberculosis.Oral, every bu is taken for twice sooner or later.

Claims

1. be used for the treatment of a Chinese medicine for pulmonary tuberculosis, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: the Radix Stemonae 10 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, Radix Peucedani 10 parts, Herba humuli scandentis 15 parts, Radix Gentianae Macrophyllae 6 parts, Cortex Lycii 10 parts.

2. be used for the treatment of the Chinese medicine of pulmonary tuberculosis as claimed in claim 1, it is characterized in that, its preparation method is: take: the Radix Stemonae 10 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, Radix Peucedani 10 parts, Herba humuli scandentis 15 parts, Radix Gentianae Macrophyllae 6 parts, Cortex Lycii 10 parts; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 parts, obtains decoct; Above-mentioned part all refers to weight portion.

3. be used for the treatment of the Chinese medicine of pulmonary tuberculosis as claimed in claim 1, it is characterized in that, its preparation method is: take: the Radix Stemonae 10 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, Radix Peucedani 10 parts, Herba humuli scandentis 15 parts, Radix Gentianae Macrophyllae 6 parts, Cortex Lycii 10 parts; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, obtains powder; Above-mentioned part all refers to weight portion.

4. be used for the treatment of the Chinese medicine of pulmonary tuberculosis as claimed in claim 1, it is characterized in that, its preparation method is: take: the Radix Stemonae 10 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, Radix Peucedani 10 parts, Herba humuli scandentis 15 parts, Radix Gentianae Macrophyllae 6 parts, Cortex Lycii 10 parts; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, obtains capsule; Above-mentioned part all refers to weight portion.